CN113368196A - Traditional Chinese medicine mixture for treating wind-heat type common cold and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine mixture for treating wind-heat type common cold, which is prepared from the following raw material medicines in parts by weight: 6 parts of mulberry leaf, 6 parts of mint, 11 parts of fructus forsythiae, 13 parts of platycodon grandiflorum, 6 parts of chrysanthemum, 12 parts of honeysuckle, 10 parts of almond, 5 parts of radix puerariae, 7 parts of fermented soya beans, 5 parts of herba schizonepetae, 6 parts of cress, 8 parts of raw liquorice, 6 parts of bamboo leaf, 6 parts of radix bupleuri, 7 parts of radix scutellariae, 10 parts of sweet wormwood, 9 parts of eupatorium, 5 parts of gardenia jasminoides, 15 parts of gypsum and 7 parts of pinellia ternate. The invention has convenient taking, definite curative effect, quick response, stable dosage form, controllable quality and no toxic or side effect, can improve the immunity of patients, and can meet the requirements of patients suffering from wind-heat type cold; the traditional Chinese medicine composition disclosed by the invention gives consideration to the protection and coordination of the functions of the heart, the liver, the lung, the spleen and the kidney, fully embodies the holistic concept and advantages of the traditional Chinese medicine, enables the medicine effect and function to be more comprehensive and treats both principal and secondary aspect of disease.

Description

Traditional Chinese medicine mixture for treating wind-heat type common cold and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine mixture for treating wind-heat type common cold and a preparation method thereof.

Background

The cold therapeutic drugs on the market are generally divided into two types, one type is western medicine, the treatment effect is quick, but the side effect is large, and the price is high; the traditional Chinese medicine is used for treating cold by differentiation of symptoms and signs, including wind-cold syndrome, wind-heat syndrome, summer-heat and dampness syndrome, exterior cold and interior heat syndrome and the like, and the wind-heat cold is caused by wind-heat evil attacking exterior and lung qi disharmony. The symptoms are marked by fever, slight nausea, distending pain in the head, sweating, red and swollen and painful throat, cough, sticky or yellow sputum, nasal obstruction, yellow nasal discharge, thirst with desire for drink, red tongue tip and edge, and thin, white and yellowish fur. The theory of the etiology of various diseases and the symptoms of wind-heat: for wind-heat syndrome, wind-heat qi enters lung from skin and hair. The lung is the upper cover of the five zang organs and the skin and hair of the body, and if the skin and striae are weakened, the skin and hair are injured first by the wind-heat, which enters the lung. Its shape can make people averse to wind and chill, want to loose eyes and spit nasal discharge. For the syndrome of exterior syndrome, it is advisable to relieve exterior syndrome with pungent and cool natured drugs and to disperse wind-heat. The prescription is prepared from honeysuckle flower and forsythia powder, mulberry leaf and chrysanthemum beverage, platycodon root soup, supernatant powder, chrysanthemum powder and the like. If the patient is not cured for a long time, the patient must be weak and must be evacuated. Ginseng and Japanese atractylodes rhizome are added for yang deficiency, rehmannia root and five flavors, ophiopogon root and white peony root are added for yin deficiency, the common wind-heat cold treatment traditional Chinese medicine has small side effect but general curative effect, and the market acceptance degree is gradually reduced because more or less bitter products are contained in the common wind-heat cold treatment traditional Chinese medicine or because partial varieties have excessive medicinal flavors and are difficult to modify, so that the traditional Chinese medicine with small side effect, good curative effect and convenient taking is needed to be developed.

Disclosure of Invention

The invention aims to make up the defects of the prior art, and provides a traditional Chinese medicine mixture for treating wind-heat type common cold and a preparation method thereof, which have the effects of dispelling cold, relieving exterior syndrome, dredging orifices and relieving pain, and have short treatment course and quick response.

The invention is realized by the following technical scheme:

a traditional Chinese medicine mixture for treating wind-heat type common cold is prepared from the following raw material medicines in parts by weight:

3-9 parts of mulberry leaf, 5-8 parts of mint, 10-15 parts of fructus forsythiae, 12-15 parts of platycodon grandiflorum, 3-9 parts of chrysanthemum, 10-14 parts of honeysuckle, 8-12 parts of almond, 3-12 parts of radix puerariae, 3-10 parts of fermented soya bean, 3-9 parts of schizonepeta, 3-9 parts of cress, 6-12 parts of raw liquorice, 3-9 parts of bamboo leaf, 3-9 parts of radix bupleuri, 3-10 parts of radix scutellariae, 8-14 parts of sweet wormwood, 5-10 parts of herba eupatorii, 3-9 parts of fructus gardeniae, 15-18 parts of gypsum and 5-9 parts of pinellia ternate.

The traditional Chinese medicine mixture is prepared from the following raw material medicines in parts by weight:

6 parts of mulberry leaf, 6 parts of mint, 11 parts of fructus forsythiae, 13 parts of platycodon grandiflorum, 6 parts of chrysanthemum, 12 parts of honeysuckle, 10 parts of almond, 5 parts of radix puerariae, 7 parts of fermented soya beans, 5 parts of herba schizonepetae, 6 parts of cress, 8 parts of raw liquorice, 6 parts of bamboo leaf, 6 parts of radix bupleuri, 7 parts of radix scutellariae, 10 parts of sweet wormwood, 9 parts of eupatorium, 5 parts of gardenia jasminoides, 15 parts of gypsum and 7 parts of pinellia ternate.

A preparation method of a traditional Chinese medicine mixture for treating wind-heat type common cold comprises the following specific steps:

(1) respectively drying folium mori, platycodon grandiflorum, chrysanthemum, honeysuckle, almond, radix puerariae, fermented soya beans, schizonepeta, cress, bamboo leaves, radix bupleuri, gypsum and pinellia ternate, grinding into fine powder, mixing the fine powder, carrying out ultrasonic extraction on the mixed fine powder by using an 80% ethanol solution to obtain an extracting solution and medicine residues, and then mixing the extracting solution and n-butyl alcohol according to a volume ratio of 1: (2-3) mixing, extracting, concentrating and recovering n-butyl alcohol to obtain an extract for later use;

(2) placing Scutellariae radix, fructus Gardeniae, Glycyrrhrizae radix, fructus forsythiae, herba Eupatorii, herba Menthae and herba Artemisiae Annuae into an extraction tank, adding 5-8 times of water, soaking for 20-30 min, heating to extract volatile oil, storing the volatile oil at 0-4 deg.C, and collecting the residue;

(3) mixing the medicine residues obtained in the step 1 and the step 2, pouring the mixture into a medicine boiler, adding 3-6 times of mass water, soaking for 20-30 minutes, heating to boil, decocting for 60-120 minutes with slow fire, and filtering to obtain a liquid medicine for later use;

(4) mixing the extract obtained in the step 1 and the liquid medicine obtained in the step 3, feeding the mixture into a medicine boiler, heating, stirring and concentrating to obtain concentrated liquid medicine, cooling to normal temperature, adding the volatile oil obtained in the step 2, stirring uniformly, weighing and bottling to obtain the mixture.

And (4) cooling to normal temperature in the step (4), and adding honey into the mixture.

In the selected raw material traditional Chinese medicinal materials, the drug effect and the pharmacological action are respectively as follows:

the mulberry leaves are sweet and bitter and cold. It enters lung and liver meridians. Disperse wind, clear lung heat and moisten dryness, clear liver and improve vision. Can be used for treating common cold, lung dryness cough, dizziness, headache, conjunctival congestion, and dim eyesight. The main components are 1 sterol, mainly including achyranthes bidentata sterone, hydroxyl ecdysterone, B-sitosterol-B-glucoside and sitosterol. 2 flavone and flavonoid glycoside, mainly rutin, and others, sanger and isoquercitrin. 3 the alkaloids mainly comprise trigonelline, choline, and polysaccharides such as adenine 4 and folium Mori polysaccharide. Other groups mainly contain volatile oil, various amino acids, vitamins and the like.

The mint is pungent and cool. It enters lung and liver meridians. Has the functions and main indications of dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, soothing liver and promoting qi circulation. The cold is treated by dry wind, the wind-warm syndrome is at the beginning, the headache is red day, the throat is shriveled, and aphtha and rubella measles are caused. Chest and hypochondrium are inflated. The main components. The volatile oil mainly contains menthol (77-78%), and menthone and menthyl acetate.

Lian Qiao can clear heat, remove toxicity, dissipate nodulation and relieve swelling. It is indicated for warm heat, erysipelas, macula, superficial infection, abscess, swelling, scrofula and stranguria.

Platycodon grandiflorum, radix Platycodonis, lung ventilating, sore throat relieving, phlegm eliminating, and pus discharging. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation.

Chrysanthemum is sweet, bitter and slightly cold. It enters lung and liver meridians. Has the functions and main indications of dispelling wind and clearing heat, calming liver and improving eyesight, and clearing heat and detoxicating. Can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, dim eyesight, sore, carbuncle, and toxic swelling. The main components are 1 volatile oil which mainly comprises borneol, camphor and chrysanthenone. 2 the flavonoids mainly comprise diosmetin, luteolin and apigenin. Farnesin, and the like. The other 3 kinds contain 17 kinds of amino acids, 8 kinds of amino acids essential for human body, trace elements essential for human body, copper, iron, zinc, etc. and chlorogenic acid.

Honeysuckle flower: sweet and cold in nature. It enters lung, heart and stomach meridians. Has the functions and main indications of clearing away heat and toxic material and dispelling wind and heat. Can be used for treating carbuncle, swelling, sore, pharyngitis, erysipelas, dysentery, wind-heat type common cold, epidemic febrile disease, and fever. The main components are chlorogenic acids 1 and glycosides 2, the glycosides include saponins, iridoid glycoside and other 3 flavonoids including 5-hydroxy-3' 47-trimethoxyflavone, luteolin-7-0-a-D-glucide, luteolin-7-0-b-D-galactoside, quercetin-3-0-b-D-glucoside, hyperin and other 4 volatile oils, and the main components are florol and argyl alcohol.

The almond has good medicinal value, such as relieving cough and asthma, enhancing human immunity, delaying senility, regulating blood fat, nourishing brain, benefiting intelligence, and the like. The content of amygdalin with various pharmacological actions in the bitter almond reaches 5.5 percent, and the modern medicine considers that the amygdalin has the action of inhibiting and killing cancer cells. The almond is widely applied to the fields of food, cosmetics, medicines and the like.

Kudzu root, sweet, pungent and cool. Has the functions of expelling pathogenic factors from muscles, allaying fever, promoting eruption, promoting the production of body fluid to quench thirst, invigorating yang and stopping diarrhea. It is commonly indicated for exterior syndrome with fever, stiffness and pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging and diarrhea due to spleen deficiency.

Fermented soya beans have mild nature and salty taste, and enter lung and stomach meridians. Has effects in regulating stomach function, relieving vexation, removing fishy smell, and removing cold and heat.

Herba Schizonepetae whole plant for preventing and treatingIt is used for treating common cold.Herba Schizonepetae is pungent and fragrant, and has effects of relieving summer-heat, inducing perspiration and fever, preventing and treating heatstroke, halitosis, chest distress and dysuresia, and can also be used for treating acute gastroenteritis.The stem and leaf of herba Schizonepetae contain abundant vitamins and microelements, and the tender stem and leaf can be used as cold sauce, flavoring agent or soup, and has good taste, appetite stimulating, and throat benefiting effects.

The cress is sweet and pungent in taste and cool in nature, enters lung and stomach channels, has the effects of clearing heat and removing toxicity, moistening lung and removing dampness, and has auxiliary curative effects on fever and cold, vomiting and diarrhea, urinary tract infection, metrorrhagia and metrostaxis, edema, hypertension and the like.Every 100 g of edible part of cress contains 2.5 g of protein, 0.6 g of fat, 4 g of carbohydrate, 38 g of dietary fiber and 39 mg of vitamin C. And volatile oil, sterols, alcohols, fatty acids, flavonoids, amino acids, etc. Has high medicinal value.

Raw licorice, replenishing qi and strengthening the middle warmer; relieving spasm and pain; moistening lung to arrest cough; purging pathogenic fire and removing toxic substances; harmonize the drugs. Mainly lassitude and poor appetite; emaciation and yellow face; palpitation and shortness of breath; abdominal pain and loose stool; limb spasm and pain; irritability; cough and asthma; swollen and sore throat; carbuncle sore and swelling pain; infantile fetal toxicity; and drug and food poisoning.

The bamboo leaves have the effects of clearing heat, relieving restlessness, promoting the production of body fluid and promoting urination. Can be used for treating fever polydipsia, infantile convulsion, cough with regurgitation, hematemesis, oliguria with reddish urine, aphtha, and tongue sore.

Bupleurum root, radix bupleuri, is a commonly used exterior syndrome-relieving herb. Is also called as Diwu, potherb mustard, mushroom grass and firewood, is bitter in nature and taste, slightly cold, and enters liver and gallbladder meridians. Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia.

The radix scutellariae is bitter in taste and cold in nature, and has the efficacies of clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding, preventing miscarriage and the like. It can be used for treating epidemic febrile disease, upper respiratory infection, cough due to lung heat, yellow gallbladder due to damp-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, threatened abortion, hypertension, carbuncle, furuncle, and sore.

Sweet wormwood herb has the effects of clearing heat, cooling blood, relieving steaming, relieving summer-heat, dispelling wind and relieving itching, and is used as an antipyretic for tidal fever due to yin deficiency, and also has the effects of relieving night sweat and heatstroke.

Gardenia jasminoides is the fruit of Gardenia jasminoides Ellis of Rubiaceae, which is the name of traditional Chinese medicine. The main treatment is as follows: fever, vexation, liver fire, conjunctival congestion, headache, damp-heat, yellow malnutrition, stranguria, dysentery with blood, hematuria, aphtha, pyocutaneous disease, toxic swelling, and sprain with swelling and pain.

The plaster stone is mainly used for treating apoplexy with chills and fever, and has the functions of relieving muscles and sweating, removing dry mouth and tongue scorch, relieving headache and toothache, and the like.

The eupatorium fortunei is neutral in nature, pungent in taste, capable of promoting diuresis, invigorating stomach and clearing summer-heat. Headache due to summer-heat and dampness; internal retention of moisture; epigastric fullness without hunger; nausea and vomiting; sweet and greasy in mouth; the query is resolved. Can be used for treating damp stagnation, gastric fullness, emesis, halitosis, sialorrhea, summer-heat dampness, headache, and chest distress.

The invention has the advantages that: 1. the invention has the advantages of convenient taking, exact curative effect, quick response, stable dosage form, controllable quality, no toxic or side effect, relieving exterior syndrome with pungent and cool natured drugs, and dispersing lung qi lightly, can improve the immunity of patients, and can meet the requirements of patients with wind-heat type cold.

2. All medicinal materials of the traditional Chinese medicine composition are medicinal and edible varieties, and the traditional Chinese medicine composition has the advantages of no hormone, no toxic or side effect, convenience in taking and obvious effect.

3. The traditional Chinese medicine composition disclosed by the invention gives consideration to the protection and coordination of the functions of the heart, the liver, the lung, the spleen and the kidney, fully embodies the holistic concept and advantages of the traditional Chinese medicine, enables the medicine effect and function to be more comprehensive and treats both principal and secondary aspect of disease.

Detailed Description

A traditional Chinese medicine mixture for treating wind-heat type common cold is prepared from the following raw material medicines in parts by weight:

6 parts of mulberry leaf, 6 parts of mint, 11 parts of fructus forsythiae, 13 parts of platycodon grandiflorum, 6 parts of chrysanthemum, 12 parts of honeysuckle, 10 parts of almond, 5 parts of radix puerariae, 7 parts of fermented soya beans, 5 parts of herba schizonepetae, 6 parts of cress, 8 parts of raw liquorice, 6 parts of bamboo leaf, 6 parts of radix bupleuri, 7 parts of radix scutellariae, 10 parts of sweet wormwood, 9 parts of eupatorium, 5 parts of gardenia jasminoides, 15 parts of gypsum and 7 parts of pinellia ternate.

A preparation method of a traditional Chinese medicine mixture for treating wind-heat type common cold comprises the following specific steps:

(1) respectively drying folium mori, platycodon grandiflorum, chrysanthemum, honeysuckle, almond, radix puerariae, fermented soya beans, schizonepeta, cress, bamboo leaves, radix bupleuri, gypsum and pinellia ternate, grinding into fine powder, mixing the fine powder, carrying out ultrasonic extraction on the mixed fine powder by using an 80% ethanol solution to obtain an extracting solution and medicine residues, and then mixing the extracting solution and n-butyl alcohol according to a volume ratio of 1: (2-3) mixing, extracting, concentrating and recovering n-butyl alcohol to obtain an extract for later use;

(2) placing Scutellariae radix, fructus Gardeniae, Glycyrrhrizae radix, fructus forsythiae, herba Eupatorii, herba Menthae and herba Artemisiae Annuae into an extraction tank, adding 5-8 times of water, soaking for 20-30 min, heating to extract volatile oil, storing the volatile oil at 0-4 deg.C, and collecting the residue;

(3) mixing the medicine residues obtained in the step 1 and the step 2, pouring the mixture into a medicine boiler, adding 3-6 times of mass water, soaking for 20-30 minutes, heating to boil, decocting for 60-120 minutes with slow fire, and filtering to obtain a liquid medicine for later use;

(4) mixing the extract obtained in the step 1 and the liquid medicine obtained in the step 3, feeding the mixture into a medicine boiler, heating, stirring and concentrating to obtain concentrated liquid medicine, cooling to normal temperature, adding the volatile oil obtained in the step 2, stirring uniformly, weighing and bottling to obtain the mixture.

And (4) cooling to normal temperature in the step (4), and adding honey into the mixture.

Typical case one:

in Song Dynasty, male, 25 years old, before treatment, the patient self-stated symptoms were rhinorrhea, cough, headache, nasal obstruction, throat pain, hoarseness and normal body temperature, using the drug of this example treatment, 3 times a day, 1 bottle each time, after one day, the symptoms of headache and rhinorrhea were relieved, three days of treatment, the symptoms of cough, nasal obstruction, throat pain and hoarseness were significantly improved, one week of treatment, and the symptoms were all disappeared.

Typical case two:

when a certain number of ju is a woman in age of 40, the patient can self-state symptoms of nasal obstruction, yellow nasal discharge, cold feeling, slight cough and the body temperature of 38 ℃ before treatment, the medicine is used for treatment 3 times a day and 1 bag each time, after 2 days of treatment, the symptoms begin to be relieved, and the body temperature is normal; after 3 days of treatment, the symptoms are obviously improved, and after 6 days of treatment, the symptoms are completely disappeared.

Typical case three:

liu Yi, male, 55 years old, before treatment, the patient self-reported symptoms are distending pain in the head, red and swollen pain in the throat, cough, yellow phlegm, nasal obstruction and yellow nasal discharge, the temperature is 38.5 ℃, the treatment is carried out by using the medicine of the embodiment 3 times a day, 1 bag is taken each time, after 2 days of treatment, the symptoms begin to be relieved, and the body temperature is normal; after one week of treatment, the symptoms all disappeared.

Claims (4)

1. A traditional Chinese medicine mixture for treating wind-heat type common cold is characterized in that: the traditional Chinese medicine mixture is prepared from the following raw material medicines in parts by weight:

3-9 parts of mulberry leaf, 5-8 parts of mint, 10-15 parts of fructus forsythiae, 12-15 parts of platycodon grandiflorum, 3-9 parts of chrysanthemum, 10-14 parts of honeysuckle, 8-12 parts of almond, 3-12 parts of radix puerariae, 3-10 parts of fermented soya bean, 3-9 parts of schizonepeta, 3-9 parts of cress, 6-12 parts of raw liquorice, 3-9 parts of bamboo leaf, 3-9 parts of radix bupleuri, 3-10 parts of radix scutellariae, 8-14 parts of sweet wormwood, 5-10 parts of herba eupatorii, 3-9 parts of fructus gardeniae, 15-18 parts of gypsum and 5-9 parts of pinellia ternate.

2. The traditional Chinese medicine mixture for treating wind-heat type common cold according to claim 1, which is characterized in that: the traditional Chinese medicine mixture is prepared from the following raw material medicines in parts by weight:

6 parts of mulberry leaf, 6 parts of mint, 11 parts of fructus forsythiae, 13 parts of platycodon grandiflorum, 6 parts of chrysanthemum, 12 parts of honeysuckle, 10 parts of almond, 5 parts of radix puerariae, 7 parts of fermented soya beans, 5 parts of herba schizonepetae, 6 parts of cress, 8 parts of raw liquorice, 6 parts of bamboo leaf, 6 parts of radix bupleuri, 7 parts of radix scutellariae, 10 parts of sweet wormwood, 9 parts of eupatorium, 5 parts of gardenia jasminoides, 15 parts of gypsum and 7 parts of pinellia ternate.

3. A preparation method of a traditional Chinese medicine mixture for treating wind-heat type common cold is characterized by comprising the following steps: the method comprises the following specific steps:

(1) respectively drying folium mori, platycodon grandiflorum, chrysanthemum, honeysuckle, almond, radix puerariae, fermented soya beans, schizonepeta, cress, bamboo leaves, radix bupleuri, gypsum and pinellia ternate, grinding into fine powder, mixing the fine powder, carrying out ultrasonic extraction on the mixed fine powder by using an 80% ethanol solution to obtain an extracting solution and medicine residues, and then mixing the extracting solution and n-butyl alcohol according to a volume ratio of 1: (2-3) mixing, extracting, concentrating and recovering n-butyl alcohol to obtain an extract for later use;

(2) placing Scutellariae radix, fructus Gardeniae, Glycyrrhrizae radix, fructus forsythiae, herba Eupatorii, herba Menthae and herba Artemisiae Annuae into an extraction tank, adding 5-8 times of water, soaking for 20-30 min, heating to extract volatile oil, storing the volatile oil at 0-4 deg.C, and collecting the residue;

(3) mixing the medicine residues obtained in the step 1 and the step 2, pouring the mixture into a medicine boiler, adding 3-6 times of mass water, soaking for 20-30 minutes, heating to boil, decocting for 60-120 minutes with slow fire, and filtering to obtain a liquid medicine for later use;

(4) mixing the extract obtained in the step 1 and the liquid medicine obtained in the step 3, feeding the mixture into a medicine boiler, heating, stirring and concentrating to obtain concentrated liquid medicine, cooling to normal temperature, adding the volatile oil obtained in the step 2, stirring uniformly, weighing and bottling to obtain the mixture.

4. The preparation method of the traditional Chinese medicine mixture for treating wind-heat type common cold according to claim 3, which is characterized in that: and (4) cooling to normal temperature in the step (4), and adding honey into the mixture.