CN114432375A - 一种用于治疗高原肺动脉高压的中药组合物 - Google Patents

一种用于治疗高原肺动脉高压的中药组合物 Download PDF

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CN114432375A
CN114432375A CN202011194024.7A CN202011194024A CN114432375A CN 114432375 A CN114432375 A CN 114432375A CN 202011194024 A CN202011194024 A CN 202011194024A CN 114432375 A CN114432375 A CN 114432375A
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吴京波
赵红宇
王志平
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Abstract

本发明涉及一种治疗高原肺动脉高压的中药组合物，它是由以下重量配比的原料药材制备而成：红景天25‑35份，三七粉5‑7份，桂枝5‑15份，赤芍10‑20份，丹参20‑40份，桃仁14‑16份，土鳖虫10‑20份，枳壳15‑25份，鸡内金10‑20份，川芎10‑20份。本发明的药物组份经辩证配伍，在作用上相辅相成，具有协同作用，共奏益智养心、温经通脉、活血化瘀、止咳平喘之功效，对高原肺动脉高压达到标本兼治的目的。经临床试验验证治疗高原肺动脉高压安全有效。

Description

一种用于治疗高原肺动脉高压的中药组合物
技术领域
本发明涉及一种治疗高原肺动脉高压的药物组合物，属于中药领域。
背景技术
高原肺动脉高压（High altitude pulmonary hypertension,HAPH）是由于高原低氧（缺氧）环境下，代偿性地使肺通气增加、血管收缩引起的，常见于高原***衡失调，导致早期的肺血管收缩以及后期的肺血管重建。
肺血管重建是最终出现的病理特征，在长期慢性高原缺氧的条件下，肺血管重构会逐渐发生发展，其主要的分子机制主要包括以下环节：①低压缺氧及继发的红细胞增多症所致内皮屏障功能的破坏；②血管平滑肌细胞的表型转换与增殖；③外膜成纤维细胞增生及胞外基质的沉积。目前西医主要治疗方案为扩张血管、抗血管重构及抗凝，效果不理想，而且长期应用副作用大，而中医中药在抗缺氧、抗氧化和活血化瘀等方面有较大优势，在高原肺动脉高压的治疗上有很好的应用前景。
发明内容
本发明人在援青支医期间，根据高原肺动脉高压特点，依据中医理论和临床试验反复验证，终于找到了有效治疗高原肺动脉高压的中药组合物，从而完成了本发明。
本发明的目的是提供一种有效治疗高原肺动脉高压的中药组合物。
本发明的技术方案为：一种治疗高原肺动脉高压的中药组合物，它是由以下重量配比的原料药材制备而成：红景天25-35份，三七粉5-7份，桂枝5-15份，赤芍10-20份，丹参20-40份，桃仁14-16份，土鳖虫10-20份，枳壳15-25份，鸡内金10-20份，川芎10-20份。
本发明的优选技术方案为：一种治疗高原肺动脉高压的中药组合物，其中药原料和重量配比为：红景天30份，三七粉6份，桂枝10份，赤芍15份，丹参30份，桃仁15份，土鳖虫15份，枳壳20份，鸡内金15份，川芎15份。
本发明中药组合物是在传统中医理论和临床试验指导下，精选药物组方。本发明中药组合物中红景天具有补气清肺，益智养心，对抗缺氧、止咳平喘之功效；三七粉具有散瘀止血、消肿定痛、补虚强壮之功效；桂枝具有发汗解肌、温经通脉之功效；赤芍具有清热凉血、散瘀止痛之功效；丹参具有活血祛瘀，通经止痛，清心除烦，凉血消痈之功效；桃仁具有活血祛瘀、润肠通便、止咳平喘之功效；土鳖虫具有疏通经络、活血散瘀、健脾养胃之功效；枳壳具有行气宽中，行痰消痞之功效；鸡内金具有健脾消食，涩精止遗、通淋化石之功效。川芎具有行气开郁、活血化瘀、止痛之功效。本发明组合物中的药物组份经辩证配伍，在作用上相辅相成，具有协同作用，共奏益智养心、温经通脉、活血化瘀、止咳平喘之功效，对高原肺动脉高压达到标本兼治的目的。
下面结合临床试验数据说明本发明的有益效果。
1、一般资料
发明人2020年5月-2020年10月间共收集高原肺动脉高压患者50例，均来自肺病门诊，年龄45-65岁，男性28例，女性22例。病程1年-10年。
2、诊断标准：①从低海拔到更高海拔（2500m以上）或长期居住在高海拔地区（海拔2500m以上）；②有低氧的临床表现，如***紫绀、血氧饱和度下降；③有不同程度的低氧性肺动脉高压，临床检查见肺动脉瓣听诊区第二心音亢进，心脏超声示肺动脉高压；④排除其他导致肺动脉高压的疾病。
3、试验方法
所有患者口服本发明按照实施例1制得煎剂，每日3次，疗程2周。
4、疗效标准
治疗前后mPAP降低的差值用△mPAP表示，治疗后mPAP＜25mmHg 为显效；治疗后25mmHg≤mPAP≤35mmHg，且△mPAP≥ 10mmHg，或者mPAP>35mmHg且△mPAP≥ 15mmHg为有效；治疗后25mmHg≤mPAP≤35mmHg 且△mPAP＜10mmHg，或者mPAP＞35mmHg且 △mPAP＜15mmHg为无效。（参考文献：包政权，刘永梅，胡进明，等.灯盏花素治疗高原低氧性肺动脉高压的临床分析[J].高原医学杂志，2010，20（2）：43-45.）。
5、治疗结果
50例患者显效30例，有效26例，无效4例，总有效率92%。治疗期间未见明显不良反应。可见本发明用于治疗高原肺动脉高压安全有效，有很好的推广应用价值。
具体实施方式
为了更好的理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：红景天30g，桂枝10g，赤芍15g，丹参30g，桃仁15g，土鳖虫15g，枳壳20g，鸡内金15g，川芎15g;加8倍量水，浸泡1小时，武火煮沸，沸后文火煎煮1小时，过滤；滤渣加6倍量水，水沸后煎煮30分钟，过滤；合并滤液，浓缩至150g，加入三七粉6g混匀，即得符合正常成人一天用量的煎剂。
用于治疗高原肺动脉高压。口服，每日早中晚三次分服。
实施例2
称取：红景天30g，桂枝10g，赤芍15g，丹参30g，桃仁15g，土鳖虫15g，枳壳20g，鸡内金15g，川芎15g；加10倍量水，浸泡1小时，武火煮沸，沸后文火煎煮1.5小时，过滤；滤渣加8倍量水，水沸后煎煮1小时，过滤；合并滤液，加入三七粉6g混匀，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗高原肺动脉高压。口服，每日早晚两次分服。
实施例3
称取：红景天30g，桂枝10g，赤芍15g，丹参30g，桃仁15g，土鳖虫15g，枳壳20g，鸡内金15g，川芎15g；加6倍量水，浸泡1小时，煎煮3次，每次煎煮30分钟，合并煎煮液，加入三七粉6g混匀，浓缩、干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗高原肺动脉高压。口服，每日早晚两次分服。

Claims (5)

1.一种治疗高原肺动脉高压的中药组合物，其特征在于：它是由以下重量配比的原料药材制备而成：红景天25-35份，三七粉5-7份，桂枝5-15份，赤芍10-20份，丹参20-40份，桃仁14-16份，土鳖虫10-20份，枳壳15-25份，鸡内金10-20份，川芎10-20份。
2.根据权利要求1所述的一种治疗高原肺动脉高压的中药组合物，优选地，它是由以下重量配比的原料药材制备而成：红景天30份，三七粉6份，桂枝10份，赤芍15份，丹参30份，桃仁15份，土鳖虫15份，枳壳20份，鸡内金15份，川芎15份。
3.根据权利要求2所述的一种治疗高原肺动脉高压的中药组合物，其特征在于，其制备方法为：称取红景天30份，桂枝10份，赤芍15份，丹参30份，桃仁15份，土鳖虫15份，枳壳20份，鸡内金15份，川芎15份;加8倍量水，浸泡1小时，武火煮沸，沸后文火煎煮1小时，过滤；滤渣加6倍量水，水沸后煎煮30分钟，过滤；合并滤液，浓缩至150g，加入三七粉6份混匀，即得煎剂；上述份均是指重量份。
4.根据权利要求2所述的一种治疗高原肺动脉高压的中药组合物，其特征在于，其制备方法为：称取红景天30份，桂枝10份，赤芍15份，丹参30份，桃仁15份，土鳖虫15份，枳壳20份，鸡内金15份，川芎15份；加10倍量水，浸泡1小时，武火煮沸，沸后文火煎煮1.5小时，过滤；滤渣加8倍量水，水沸后煎煮1小时，过滤；合并滤液，加入三七粉6份混匀，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
5.根据权利要求2所述的一种治疗高原肺动脉高压的中药组合物，其特征在于，其制备方法为：称取红景天30份，桂枝10份，赤芍15份，丹参30份，桃仁15份，土鳖虫15份，枳壳20份，鸡内金15份，川芎15份；加6倍量水，浸泡1小时，煎煮3次，每次煎煮30分钟，合并煎煮液，加入三七粉6份混匀，浓缩、干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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