CN104491823A - 一种治疗痛经的中药冲剂及其制备方法 - Google Patents
一种治疗痛经的中药冲剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗痛经的中药冲剂及其制备方法,制成该冲剂有效成分的原料药组成为:熟地黄,当归,生白芍,川芎,益母草,干姜,蓝桉,葱白,葱须,艾叶,橙子核,分心木,海参,草乌,洋金花,辅料填充剂为红糖。该冲剂采用全中药制剂,且不含大寒、大凉类药物,不会造成痛经症状加重,本发明的冲剂见效快、疗效好、标本兼治、且可防治经期感冒,是理想的治疗痛经的药物。
Description
技术领域
本发明涉及一种治疗痛经的中药冲剂其制备方法,属于中药制剂技术领域。
背景技术
痛经是现代女性常见疾病,其症状除剧烈腹痛外,还经常伴有呕吐、腹泻症状,给女性带来很大的痛苦。用西药止疼药治疗痛经会产生副作用,容易产生药物依赖性,且治标不治本。中医认为痛经的原因是冲任瘀阻,寒凝经脉,造成气血不畅,经血受阻,以致“不通则痛”,因此常用温经通络、平衡阴阳的方法从根源上调理机体,治疗痛经,但中药疗效一般过慢,不能快速缓解患者疼痛。同时,女性在经期前后身体虚弱,免疫抵抗力普遍较差,痛经患者气血不通,免疫抵抗力更弱,极易患感冒,由于西药副作用大,经期患感冒多用中成药进行治疗,治疗感冒的中药多为寒凉性,经期服用这类会加重痛经的症状,影响痛经的治疗。
发明内容
本发明的目的在于:为避免西药的副作用和中药起效慢的缺点,提供一种治疗痛经的中药冲剂,通过平衡阴阳、温经通络、镇静止痛、化瘀散结、理气舒缓的方法,在根治痛经的同时有效缓解腹痛、呕吐、腹泻的症状。并且能够提高机体免疫力,防治经期感冒。
为了实现上述目的,本发明提供的技术方案中摒弃了常用颗粒剂辅料填充剂,改用红糖作为本冲剂的辅料填充剂,同时,在原料中添加了海参等补益类药物和葱白、葱须,以起杀菌消毒、提高免疫力、防治感冒的作用。具体技术方案如下:
本发明提供了一种治疗痛经的中药冲剂,制成所述冲剂有效成分的原料药组成及重量份数为:熟地黄3-8份,当归5-10份,生白芍8-12份,川芎8-12份,益母草8-12份,干姜8-12份,蓝桉13-18份,葱白13-18份,葱须13-18份,艾叶13-18份,橙子核3-8份,分心木3-8份,海参2-5份,草乌12-15份,洋金花12-17份,辅料填充剂为红糖,其重量份数为60-90份。
进一步的,上述一种治疗痛经的中药冲剂,优选的,制成所述冲剂有效成分的原料药组成及重量份数为:熟地黄3份,当归5份,生白芍8份,川芎8份,益母草8份,干姜8份,蓝桉13份,葱白13份,葱须13份,艾叶13份,橙子核3份,分心木3份,海参2份,草乌12份,洋金花12份,辅料填充剂为红糖,其重量份数为60份。
进一步的,上述一种治疗痛经的中药冲剂,优选的,制成所述冲剂有效成分的原料药组成及重量份数为:熟地黄8份,当归10份,生白芍12份,川芎12份,益母草12份,干姜12份,蓝桉18份,葱白18份,葱须18份,艾叶18份,橙子核8份,分心木8份,海参5份,草乌15份,洋金花17份,辅料填充剂为红糖,其重量份数为90份。
进一步的,上述一种治疗痛经的中药冲剂,优选的,制成所述冲剂有效成分的原料药组成及重量份数为:熟地黄6份,当归7份,生白芍10份,川芎10份,益母草10份,干姜10份,蓝桉15份,葱白16份,葱须15份,艾叶15份,橙子核6份,分心木6份,海参4份,草乌13份,洋金花15份,辅料填充剂为红糖,其重量份数为80份。
本发明还提供了所述的治疗痛经的中药冲剂的制备方法,包括以下步骤:
步骤1:葱白按重量均分为两份,其中一份研磨成泥备用;
步骤2:熟地黄,当归,生白芍,川芎,益母草,干姜,蓝桉,葱须,艾叶,橙子核,分心木,草乌,洋金花和步骤1中剩余的葱白加入重量倍数为6-10倍的水,煎煮两次,每次煎煮45-60分钟,煎煮后过滤;合并两次的滤液,浓缩至相对密度为1.10~1.15(60℃),得浓缩液,加入乙醇,使乙醇的质量分数达65%,搅匀,静置24~48小时,过滤并回收乙醇,浓缩至相对密度为1.30~1.32(60℃)的稠膏;
步骤:3:海参研末,过100目筛,得海参粉;
步骤4:将步骤1中制得的葱白泥和步骤3中制得的海参粉加入步骤2中制得的稠膏中,搅拌均匀,再加入填充剂红糖,混匀,制粒,干燥,即得。
本发明为了治疗痛经,采用平衡阴阳、温经通络、镇静止痛、化瘀散结、理气舒缓、杀菌消毒、发汗解表、增强免疫力的方法,在标本兼治痛经的同时,有效防治感冒,避免经期感冒服用寒凉类感冒药造成的痛经症状加重。根据中医药理论辨证论治,通过大量实验筛选中药原料,精炼制剂方法,使得各药物功效产生协同作用,从而达到标本兼治的效果。选取的原料药和辅料的功效分别是:熟地黄:滋阴补血,益精填髓。用于肝肾阴虚,腰膝酸软,骨蒸潮热,盗汗遗精,内热消渴,血虚萎黄,心悸怔忡,***,崩漏下血,眩晕,耳鸣,须发早白;当归:补血活血,调经止痛,润肠通便。用于血虚萎黄,眩晕心悸,***,经闭痛经,虚寒腹痛,肠燥便秘,风湿痹痛,跌扑损伤,痈疽疮疡;生白芍:平肝止痛,养血调经,敛阴止汗。用于头痛眩晕,胁痛,腹痛,四肢挛痛,血虚萎黄,***,自汗,盗汗;川芎:活血行气,祛风止痛。用于***,经闭痛经,症瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛;益母草:活血调经,行血散瘀,利尿。主治***,产后血瘀腹痛,水肿,小便不利,亦常用于外科痈肿,外伤瘀血作痛等症;干姜:味辛,性热,温中散寒,回阳通脉,温肺化饮,用于脘腹冷痛,呕吐泄泻,肢冷脉微,寒饮喘咳;蓝桉:味微辛、微苦,性平。疏风解热,抑菌消炎,防腐止痒。用于预防流行性感冒、流行性脑脊髓膜炎,治上呼吸道感染,咽喉炎,支气管炎,肺炎,急、慢性肾盂肾炎,肠炎,痢疾,丝虫病;外用治烧烫伤,蜂窝织炎,乳腺炎,疖肿,丹毒,水田皮炎,皮肤湿疹,脚癣,皮肤消毒;葱白:味辛,性温,具有发汗解表,通达阳气的功效。主要用于外感风寒,阴寒内盛,格阳于外,脉微,厥逆,腹泻。生葱白中含有的挥发油成分具有杀菌消毒的作用;葱须:昧辛,性平,祛风散寒,解毒,散瘀,主治风寒头痛,喉疮,痔疮,冻伤;艾叶:苦辛,温。入脾、肝、肾经。理气血,逐寒湿,温经,止血,安胎。治心腹冷痛,泄泻转筋,久痢,吐衄,下血,***,崩漏,带下,胎动不安,痈疡,疥癣;橙子核:苦、平、无毒、微温。归膀胱、肾经,理气、止痛、利尿通淋。治疝气,淋病,腰痛;分心木:味苦涩,性平,无毒,健脾固肾,收涩精气,治遗精滑泄,淋病,尿血,遗溺,崩中,带下,泻痢,失眠;海参:性微寒,补肾益精,养血润燥,主治精血亏损,虚弱劳怯,阳痿,梦遗,肠燥便秘,肺虚咳嗽咯血,肠风便血,外伤出血,长期服用有提高免疫力的功效;草乌:归心、肝、肾、脾经,祛风除湿,温经止痛;洋金花:平顺止咳,麻醉止痛,解痉止搐;红糖:甘甜、温润、无毒。入肝、脾。功效:润心肺,和中助脾,缓肝气,解酒毒,补血,破瘀。
其中,熟地黄、当归、生白芍、川芎、益母草、艾叶为君药,起温经活络平衡阴阳、调经养血的作用;干姜性热、温经散寒,作为臣药可辅助君药回阳通脉,同时具有治疗呕吐腹泻的作用可有效缓解痛经症状;橙子核理气,分心木健脾固肾,作为辅药能促进君药调理机体的作用,增强药效,同时,橙子核还应止痛的功效,其与草乌、洋金花作为辅药协同作用,能在增强君药作用的同时快速缓解腹痛症状;蓝桉、葱白、葱须、海参作为辅药均有防治感冒的作用,葱白和葱须有驱寒、发汗解表的作用,可以防治风寒感冒,生葱白和蓝桉还具有杀菌消毒的作用,可防止细菌性感冒,海参以及当归、熟地黄等补益类药通过固本培元提高自身抵抗力来起到防治感冒的作用;同时,辅料填充剂红糖也具有补血破瘀的作用,其与干姜与葱白、葱须协同作用可增强祛风驱寒、发汗解表的作用,有效缓解痛经症状、防治感冒;本冲剂所选原料药均无大寒、大凉药物,而是采用补益类药物、杀菌类药物和祛寒解表类药物在治疗痛经的同时防治感冒,有效避免了经期感染感冒服用寒凉性药物而导致的痛经症状加重。以上诸药合用,具有很好的治疗痛经、防治感冒的功效,并且诸药相互调理,对机体不良影响小,临床应用更加安全。
本发明的有益效果为:本发明提供了一种治疗痛经的中药冲剂,有效避免了西药副作用、药物依赖性强,以及中药制剂起效慢、疗程长的缺点的缺陷。该冲剂具有起效快、疗效好标本兼治的优点,采用草乌、洋金花等镇痛类药和干姜、葱白等止吐止泻类药,快速有效缓解痛经的腹痛、呕吐、腹泻症状;采用海参等补益类药全面调节机体,温经通络,祛除寒气,平衡阴阳,固本培元,从根本上治疗痛经,提高患者自身免疫力。同时,结合补益类药、性平或性温的杀菌类药和祛寒解表类药有效防治经期感冒,避免经期服用寒凉性感冒药造成痛经症状加重,影响治疗效果。该冲剂选取红糖作为填充剂,充分利用了红糖补血破瘀的作用,增强了原料药有效成分的作用。本发明的冲剂见效快、疗效好、标本兼治、且可防治经期感冒,是理想的治疗痛经的药物。
具体实施方式
根据下述实施例,可以更好地理解本发明。然而,本领域的技术人员容易理解,实施例所描述的具体的物料配比、工艺条件及其结果仅用于说明本发明而不应当也不会限制权利要求书中所详细描述的本发明。
实施例1制备治疗痛经的中药冲剂
配方为:熟地黄30克,当归50克,生白芍80克,川芎80克,益母草80克,干姜80克,蓝桉130克,葱白130克,葱须130克,艾叶130克,橙子核30克,分心木30克,海参20克,草乌120克,洋金花120克,红糖600克。
配制方法为:
步骤1:葱白按重量均分为两份,其中一份研磨成泥备用;
步骤2:熟地黄,当归,生白芍,川芎,益母草,干姜,蓝桉,葱须,艾叶,橙子核,分心木,草乌,洋金花和步骤1中剩余的葱白加入重量倍数为6倍的水,煎煮两次,每次煎煮60分钟,煎煮后过滤;合并两次的滤液,浓缩至相对密度为1.15(60℃),得浓缩液,加入乙醇,使乙醇的质量分数达65%,搅匀,静置48时,过滤并回收乙醇,浓缩至相对密度为1.30(60℃)的稠膏;
步骤:3:海参研末,过100目筛,得海参粉;
步骤4:将步骤1中制得的葱白泥和步骤3中制得的海参粉加入步骤2中制得的稠膏中,搅拌均匀,再加入填充剂红糖,混匀,制粒,干燥,即得。
治疗时,饭前沸水冲服,每次15克,一日二次。
实施例2制备治疗痛经的中药冲剂
配方为:熟地黄80克,当归100克,生白芍120克,川芎120克,益母草120克,干姜120克,蓝桉180克,葱白180克,葱须180克,艾叶180克,橙子核80克,分心木80克,海参50克,草乌150克,洋金花170克,红糖900克。
配置方法与实施例1中相似,区别在于:步骤3中加入重量倍数为10倍的水,,煎煮两次,每次煎煮45分钟,煎煮后过滤;合并两次的滤液,浓缩至相对密度为1.10(60℃),得浓缩液,加入乙醇使乙醇的质量分数达65%,搅匀,静置24小时,过滤并回收乙醇,浓缩至相对密度为1.32(60℃)的稠膏;
治疗时,饭前沸水冲服,每次15克,一日二次。
实施例3制备治疗痛经的中药冲剂
配方为:熟地黄60克,当归70克,生白芍100克,川芎100克,益母草100克,干姜100克,蓝桉150克,葱白160克,葱须150克,艾叶150克,橙子核60克,分心木60克,海参40克,草乌130克,洋金花150克,红糖800克。
配置方法与实施例1中相似,区别在于:步骤3中加入重量倍数为8倍的水,,煎煮两次,每次煎煮50分钟,煎煮后过滤;合并两次的滤液,浓缩至相对密度为1.13(60℃),得浓缩液,加入乙醇使乙醇的质量分数达65%,搅匀,静置36小时,过滤并回收乙醇,浓缩至相对密度为1.31(60℃)的稠膏;
治疗时,饭前沸水冲服,每次15克,一日二次。
实施例4临床试验研究
给予本发明实施例1至3任一项的中药冲剂,治疗时,饭前沸水冲服,每次15克,一日二次,1月为1疗程,连服3个疗程后观察疗效。
随机选取100名痛经患者,年龄14-48岁,平均31岁,其中,92人为原发性痛经患者,8人为继发性痛经患者,100位患者均有腹痛症状,其中73人有恶心呕吐症状,26人有腹泻症状;在治疗痛经方面,服用本冲剂3个疗程,15人痊愈,痛经症状消除,且停药后6个月内无复发;40人有显著疗效,痛经症状基本消除,但停药后6个月内症状有反复需继续服药;42人有疗效,痛经症状有所缓解或部分消除,需继续服药治疗;3人无疗效,总有效率97%。100名服药本冲剂治疗的患者均无病情加重症状。
临床典型实施例:
1、肖某某,18岁,女,原发性痛经,经期腹痛,且伴有恶心呕吐症状,服用实施例1的中药冲剂当月,恶心呕吐症状消除,腹痛有所缓解,连续服药3个月后,痛经症状消除,停药6个月内未复发。
2、齐某,45岁,女,继发性痛经,经期剧烈腹痛,伴有呕吐腹泻症状,需服用西药止痛药缓解疼痛,服用实施例2的中药冲剂当月呕吐腹泻症状缓解,腹痛症状明显缓解,可停用止痛药,连续服药3个月后,呕吐腹泻症状消除,腹痛症状明显缓解不需再服用止痛药。
3、薛某,32岁,女,原发性痛经,经期剧烈腹痛,长期依赖止痛药,服用实施例3的中药冲剂当月腹痛症状有所缓解,连续服药3个月后,腹痛症状消失,不需再服用止痛药,停药2个月病情复发,继续服药3个月后痊愈,停药6个月无复发。
结果表明,本发明的治疗痛经的中药冲剂,能够快速缓解痛经症状,标本兼治痛经,且可有效防治经期感冒,是理想的治疗痛经的药物。
以上实施方式只为说明本发明的技术构思及特点,其目的在于让熟悉此项技术的人了解本发明内容并加以实施,并不能以此限制本发明的保护范围,凡根据本发明精神实质所做的等效变化或修饰,都应涵盖在本发明的保护范围内。
Claims (5)
1.一种治疗痛经的中药冲剂,其特征在于:制成所述冲剂有效成分的原料药组成及重量份数为:熟地黄3-8份,当归5-10份,生白芍8-12份,川芎8-12份,益母草8-12份,干姜8-12份,蓝桉13-18份,葱白13-18份,葱须13-18份,艾叶13-18份,橙子核3-8份,分心木3-8份,海参2-5份,草乌12-15份,洋金花12-17份,辅料填充剂为红糖,其重量份数为60-90份。
2.如权利要求1所述的治疗痛经的中药冲剂,其特征在于:制成所述冲剂有效成分的原料药组成及重量份数为:熟地黄3份,当归5份,生白芍8份,川芎8份,益母草8份,干姜8份,蓝桉13份,葱白13份,葱须13份,艾叶13份,橙子核3份,分心木3份,海参2份,草乌12份,洋金花12份,辅料填充剂为红糖,其重量份数为60份。
3.如权利要求1所述的治疗痛经的中药冲剂,其特征在于:制成所述冲剂有效成分的原料药组成及重量份数为:熟地黄8份,当归10份,生白芍12份,川芎12份,益母草12份,干姜12份,蓝桉18份,葱白18份,葱须18份,艾叶18份,橙子核8份,分心木8份,海参5份,草乌15份,洋金花17份,辅料填充剂为红糖,其重量份数为90份。
4.如权利要求1所述的治疗痛经的中药冲剂,其特征在于:制成所述冲剂有效成分的原料药组成及重量份数为:熟地黄6份,当归7份,生白芍10份,川芎10份,益母草10份,干姜10份,蓝桉15份,葱白16份,葱须15份,艾叶15份,橙子核6份,分心木6份,海参4份,草乌13份,洋金花15份,辅料填充剂为红糖,其重量份数为80份。
5.权利要求1所述的治疗痛经的中药冲剂的制备方法,其特征在于:包括以下步骤:
步骤1:葱白按重量均分为两份,其中一份研磨成泥备用;
步骤2:熟地黄,当归,生白芍,川芎,益母草,干姜,蓝桉,葱须,艾叶,橙子核,分心木,草乌,洋金花和步骤1中剩余的葱白加入重量倍数为6-10倍的水,煎煮两次,每次煎煮45-60分钟,煎煮后过滤;合并两次的滤液,浓缩至相对密度为1.10~1.15(60℃),得浓缩液,加入乙醇,使乙醇的质量分数达65%,搅匀,静置24~48小时,过滤并回收乙醇,浓缩至相对密度为1.30~1.32(60℃)的稠膏;
步骤3:海参研末,过100目筛,得海参粉;
步骤4:将步骤1中制得的葱白泥和步骤3中制得的海参粉加入步骤2中制得的稠膏中,搅拌均匀,再加入填充剂红糖,混匀,制粒,干燥,即得。
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