CN114392328A - Chinese herbal medicine freckle removing paste and preparation method thereof - Google Patents
Chinese herbal medicine freckle removing paste and preparation method thereof Download PDFInfo
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The application discloses a Chinese herbal medicine freckle removing paste which is prepared from the following raw materials in parts by weight: 50-90 parts of almond, 40-80 parts of pseudo-ginseng, 30-70 parts of watermelon seed, 20-60 parts of coix seed, 20-60 parts of pearl powder, 20-60 parts of Chinese waxgourd seed, 10-50 parts of saffron and 60-100 parts of modified chitosan. The Chinese herbal medicine components are properly compatible, the assistant and guide synergy is realized, the drug effect is fully exerted, the effect taking speed is high, no corrosive damage is caused to the skin, no stimulation is caused to the skin, certain whitening and beautifying effects are realized, and the Chinese herbal medicine composition is suitable for wide crowds.
Description
Technical Field
The application relates to a Chinese herbal medicine freckle-removing ointment and a preparation method thereof, belonging to the technical field of traditional Chinese medicine ointment preparation.
Background
The facial freckles are black brown small spots on the face, are represented by light brown or dark brown punctate pigmentation spots, are round, oval or irregular, have clear boundaries, are generally about 2mm in diameter, have smooth surfaces, are isolated and not fused, are distributed in different densities, depend on the amount of sunlight absorbed and the sunlight tolerance of individuals, and are large in number and large in body in summer and dark brown, so that the freckles are lightened in winter. Modern research considers that excessive melanin production by the skin is a main factor causing pigmentation skin diseases such as chloasma and melanoma, and tyrosinase is a key enzyme in the melanin biosynthesis process.
The freckles really become great troubles for people, especially for many women, at present, the treatment of the freckles is relatively complicated, the cost of intense pulse light is relatively expensive, the traditional ointment has certain corrosivity, the sterilization and repair effects are general, the effect taking speed is slow, the treatment period is long, and the use is troublesome.
Disclosure of Invention
In order to solve the problems, the Chinese herbal medicine freckle-removing cream and the preparation method thereof are provided, the Chinese herbal medicine components are properly compatible, the assistant and guide synergy is realized, the drug effect is fully exerted, the effect taking speed is high, no corrosive damage is caused to the skin, no stimulation is caused to the skin, certain whitening and beautifying effects are achieved, and the application range of people is wide.
According to one aspect of the application, the Chinese herbal medicine freckle removing paste is prepared from the following raw materials in parts by weight: 50-90 parts of almond, 40-80 parts of pseudo-ginseng, 30-70 parts of watermelon seed, 20-60 parts of coix seed, 20-60 parts of pearl powder, 20-60 parts of Chinese waxgourd seed, 10-50 parts of saffron and 60-100 parts of modified chitosan.
Optionally, the feed additive is prepared from the following raw materials in parts by weight: 50-70 parts of almond, 40-60 parts of pseudo-ginseng, 30-50 parts of watermelon seed, 20-40 parts of coix seed, 20-40 parts of pearl powder, 20-40 parts of Chinese waxgourd seed, 10-30 parts of saffron and 60-80 parts of modified chitosan.
Optionally, the feed additive is prepared from the following raw materials in parts by weight: 50-70 parts of almond, 40-60 parts of pseudo-ginseng, 30-50 parts of watermelon seed, 20-40 parts of coix seed, 20-40 parts of pearl powder, 20-40 parts of Chinese waxgourd seed, 10-30 parts of saffron and 60-80 parts of modified chitosan.
Optionally, the feed additive is prepared from the following raw materials in parts by weight: 60 parts of almond, 50 parts of pseudo-ginseng, 40 parts of watermelon seed, 30 parts of coix seed, 30 parts of pearl powder, 30 parts of Chinese waxgourd seed, 20 parts of saffron and 70 parts of modified chitosan.
Optionally, the modified chitosan is prepared from carboxymethyl chitosan, a modifier and sodium borohydride.
Optionally, the modifier is trimethylpyruvic acid and/or pyruvic acid.
Preferably, the modifier is trimethylpyruvic acid.
Optionally, the preparation method of the modified chitosan comprises the steps of mixing carboxymethyl chitosan with water, adding a modifier, stirring for 2-3 hours, adding a sodium borohydride solution, stirring for 1-3 hours, filtering, washing and drying to obtain the modified chitosan.
Preferably, the weight ratio of the carboxymethyl chitosan to the trimethylpyruvic acid to the sodium borohydride is 1:1:3, the concentration of the sodium borohydride solution is 0.5g/mL, and the water amount is 2 times that of the carboxymethyl chitosan.
Specifically, mixing carboxymethyl chitosan with water, adding trimethylpyruvic acid, stirring for 2h, adding 5ml of sodium borohydride solution, stirring for 2h, filtering, washing and drying to obtain the modified chitosan.
According to another aspect of the application, a preparation method of the Chinese herbal medicine freckle removing cream is provided, and the preparation method comprises the following steps:
(1) mixing semen Citrulli, Coicis semen and semen Benincasae, placing in a decocting pot, decocting in water, filtering to obtain first decoction, adding the first decoction into a vacuum concentrator, heating and concentrating under stirring, and collecting paste;
(2) mixing Notoginseng radix and stigma croci Sativi, placing in a decocting pot, decocting in water, and filtering to obtain a second decoction;
(3) adding almond, pearl powder and modified chitosan into a pulverizer, pulverizing and sieving to obtain first mixed powder;
(4) adding the second decoction into a vacuum concentrator, adding the first mixed powder, stirring, heating, concentrating, cooling, and crushing to obtain second mixed powder;
(5) and (3) adding the second mixed powder into the paste prepared in the step (1), and uniformly stirring to obtain the Chinese herbal medicine freckle removing paste.
Optionally, the decocting time in step (1) and step (2) is 1-2h, the water addition amount in step (1) is 4-6 times of the total amount of the Chinese herbal medicines in the step, and the water addition amount in step (2) is 5-8 times of the total amount of the Chinese herbal medicines in the step;
the stirring speed in the step (1) and the step (5) is 30-40r/min, and the stirring speed in the step (4) is 100-150 r/min.
Optionally, the heating temperature in the step (1) and the heating temperature in the step (2) are both 80-90 ℃, the heating temperature in the step (4) is 70-90 ℃, and the vacuum heating time is 0.2-0.4 h; sieving in the step (3) by using a sieve of 150-;
concentrating in the step (1) until the relative density of the paste is 1.2-1.4; and (4) concentrating until the relative density of the mixture is 1.2-1.5.
In the present application, "water" refers to purified water.
Benefits of the present application include, but are not limited to:
1. according to the Chinese herbal medicine freckle-removing ointment, the Chinese herbal medicine components are properly compatible, the assistant and guide synergy is achieved, the medicine effect is fully exerted, the effect taking speed is high, no corrosive damage is caused to skin, no stimulation is caused to the skin, certain whitening and beautifying effects are achieved, and the application range is wide.
2. According to the Chinese herbal medicine freckle-removing paste, the almond contains rich fatty oil, protein, vitamin A, vitamin E and mineral substances, and has the effects of resisting oxidation, promoting facial metabolism and inhibiting formation of freckles and chloasma; the pseudo-ginseng can relax the channels and activate collaterals, replenish qi and blood, accelerate blood microcirculation in the skin and has the effects of beautifying and spot fading; the watermelon seed contains fatty oil, protein, and vitamin B2Alpha-amino-beta- (pyrazolyl-N) propionic acid to supplement nutrients required for facial restoration; the pearl powder contains a large amount of trace elements, which can help to inhibit the increase of lipid peroxide, increase the proliferation and differentiation of cells, improve the blood circulation and effectively remove spots; the coix seed can promote metabolism, cell immunity and humoral immunity; semen Benincasae contains saponin, fat, etc., has effects of resolving macula, whitening, caring skin, activating tyrosinase, and reducing melanin formation; the saffron has the effects of clearing away heat and toxic materials, promoting blood circulation, removing blood stasis, accelerating the decomposition of melanin in skin basal layer, and inhibiting the activity of tyrosinase.
3. According to the Chinese herbal medicine freckle removing paste, the chitosan is modified by using the modifier, so that the chitosan C is obtained2The active hydrogen on the site reacts with a modifier to generate a polymer with high substituted carboxyl, so that the modified chitosan has excellent adsorption performance, can adsorb easily lost effective components such as almond, pearl powder and the like, and enhances the treatment effect; meanwhile, the modified chitosan still has excellent bactericidal effect and good biocompatibility, and can effectively promote wound healing and improve blood circulation of affected parts.
4. According to the preparation method of the Chinese herbal medicine freckle removing cream, the modified chitosan, the almond, the pearl powder and the concentrate of the second decoction are crushed into mixed powder, so that the effective components are uniformly dispersed in the previously prepared cream, the loss of the effective components can be reduced, the full utilization of the medicine effect can be realized, the effect taking speed is high, and the treatment period is short.
Detailed Description
The present application will be described in detail with reference to examples, but the present application is not limited to these examples.
The raw materials in the examples of the present application were all purchased commercially, unless otherwise specified. The vacuum concentration equipment is a YZN50 vacuum concentrator of Donghua original medical company, and the state of vacuum concentration refers to that the air pressure in the vacuum tank is lower than the atmospheric pressure, in other words, the vacuum tank is in a negative pressure state, and the specific vacuum degree is-0.05 MPa-0.08 MPa. Other parameters of vacuum concentration are not mentioned, but all parameters used in the prior art.
Example 1 preparation of freckle removing cream # 1
The composite material is prepared from the following raw materials in parts by weight: 60 parts of almond, 50 parts of pseudo-ginseng, 40 parts of watermelon seed, 30 parts of coix seed, 30 parts of pearl powder, 30 parts of Chinese waxgourd seed, 20 parts of saffron and 70 parts of modified chitosan;
the preparation method of the modified chitosan comprises the steps of mixing carboxymethyl chitosan with water, adding trimethylpyruvic acid, stirring for 2 hours, adding 5ml of sodium borohydride solution, stirring for 2 hours, filtering, washing and drying to obtain the modified chitosan; wherein the weight ratio of the carboxymethyl chitosan to the trimethylpyruvic acid to the sodium borohydride is 1:1:3, the concentration of the sodium borohydride solution is 0.5g/mL, and the water amount is 2 times of that of the carboxymethyl chitosan.
The preparation method of the freckle removing paste 1# comprises the following steps:
(1) mixing semen Citrulli, Coicis semen and semen Benincasae, placing in a decocting pot, decocting in water, filtering to obtain first decoction, adding the first decoction into a vacuum concentrator, heating and concentrating under stirring, and collecting paste;
(2) mixing Notoginseng radix and stigma croci Sativi, placing in a decocting pot, decocting in water, and filtering to obtain a second decoction;
(3) adding almond, pearl powder and modified chitosan into a pulverizer, pulverizing and sieving to obtain first mixed powder;
(4) adding the second decoction into a vacuum concentrator, adding the first mixed powder, stirring, heating, concentrating, cooling, and crushing to obtain second mixed powder;
(5) adding the second mixed powder into the paste prepared in the step (1), and uniformly stirring to obtain the Chinese herbal medicine freckle removing paste # 1.
Wherein, the decocting time in the step (1) and the step (2) is 1.5h, the water adding amount in the step (1) is 5 times of the total amount of the Chinese herbal medicines in the step, and the water adding amount in the step (2) is 6 times of the total amount of the Chinese herbal medicines in the step; the stirring speed in the step (1) and the stirring speed in the step (5) are both 35r/min, and the stirring speed in the step (4) is 120 r/min.
The heating temperature in the step (1) and the heating temperature in the step (2) are both 85 ℃, the heating temperature in the step (4) is 80 ℃, and the vacuum heating time is 0.3 h; sieving in step (3) with a 170-mesh sieve; concentrating in the step (1) until the relative density of the paste is 1.3; and (4) concentrating until the relative density of the mixture is 1.3.
Example 2 preparation of freckle removing cream # 2
The composite material is prepared from the following raw materials in parts by weight: 50 parts of almond, 40 parts of pseudo-ginseng, 30 parts of watermelon seed, 20 parts of coix seed, 20 parts of pearl powder, 20 parts of Chinese waxgourd seed, 10 parts of saffron and 60 parts of modified chitosan; the modified chitosan was prepared in the same manner as in example 1.
The preparation method of the freckle removing paste 2# comprises the following steps:
(1) mixing semen Citrulli, Coicis semen and semen Benincasae, placing in a decocting pot, decocting in water, filtering to obtain first decoction, adding the first decoction into a vacuum concentrator, heating and concentrating under stirring, and collecting paste;
(2) mixing Notoginseng radix and stigma croci Sativi, placing in a decocting pot, decocting in water, and filtering to obtain a second decoction;
(3) adding almond, pearl powder and modified chitosan into a pulverizer, pulverizing and sieving to obtain first mixed powder;
(4) adding the second decoction into a vacuum concentrator, adding the first mixed powder, stirring, heating, concentrating, cooling, and crushing to obtain second mixed powder;
(5) adding the second mixed powder into the paste prepared in the step (1), and uniformly stirring to obtain the Chinese herbal medicine freckle removing paste # 2.
Wherein, the decocting time in the step (1) and the step (2) is 1h, the water adding amount in the step (1) is 4 times of the total amount of the Chinese herbal medicines in the step, and the water adding amount in the step (2) is 5 times of the total amount of the Chinese herbal medicines in the step; the stirring speed in the step (1) and the stirring speed in the step (5) are both 30r/min, and the stirring speed in the step (4) is 100 r/min.
The heating temperature in the step (1) and the heating temperature in the step (2) are both 80 ℃, the heating temperature in the step (4) is 70 ℃, and the vacuum heating time is 0.2 h; sieving in step (3) with a 150-mesh sieve; concentrating in the step (1) until the relative density of the paste is 1.2; and (4) concentrating until the relative density of the mixture is 1.2.
Example 3 preparation of freckle removing cream # 3
The composite material is prepared from the following raw materials in parts by weight: 90 parts of almond, 80 parts of pseudo-ginseng, 70 parts of watermelon seed, 60 parts of coix seed, 60 parts of pearl powder, 60 parts of Chinese waxgourd seed, 50 parts of saffron and 100 parts of modified chitosan;
the modified chitosan was prepared in the same manner as in example 1.
The preparation method of the freckle removing paste 3# comprises the following steps:
(1) mixing semen Citrulli, Coicis semen and semen Benincasae, placing in a decocting pot, decocting in water, filtering to obtain first decoction, adding the first decoction into a vacuum concentrator, heating and concentrating under stirring, and collecting paste;
(2) mixing Notoginseng radix and stigma croci Sativi, placing in a decocting pot, decocting in water, and filtering to obtain a second decoction;
(3) adding almond, pearl powder and modified chitosan into a pulverizer, pulverizing and sieving to obtain first mixed powder;
(4) adding the second decoction into a vacuum concentrator, adding the first mixed powder, stirring, heating, concentrating, cooling, and crushing to obtain second mixed powder;
(5) adding the second mixed powder into the paste prepared in the step (1), and uniformly stirring to obtain the Chinese herbal medicine freckle removing paste # 3.
Wherein, the decocting time in the step (1) and the step (2) is 2 hours, the water adding amount in the step (1) is 6 times of the total amount of the Chinese herbal medicines in the step, and the water adding amount in the step (2) is 8 times of the total amount of the Chinese herbal medicines in the step; the stirring speed in the step (1) and the stirring speed in the step (5) are both 40r/min, and the stirring speed in the step (4) is 150 r/min.
The heating temperature in the step (1) and the heating temperature in the step (2) are both 90 ℃, the heating temperature in the step (4) is 90 ℃, and the vacuum heating time is 0.4 h; sieving in step (3) with 200 mesh sieve; concentrating in the step (1) until the relative density of the paste is 1.4; and (4) concentrating until the relative density of the mixture is 1.5.
Comparative example 1 preparation of freckle removing cream No. 4
The preparation method of the freckle removing paste No. 4 is the same as that of the freckle removing paste No. 1, except that: the freckle removing cream No. 4 does not use modified chitosan.
Comparative example 2 preparation of freckle removing cream No. 5
The preparation method of the freckle removing paste 5# is the same as that of the freckle removing paste 1# except that: in the freckle removing paste No. 5, sodium hydroxide is used for modifying chitosan, specifically, 0.5g/mL sodium hydroxide solution is used for modifying, and the weight ratio of the sodium hydroxide to the carboxymethyl chitosan is 1: 1.
Comparative example 3 preparation of freckle removing cream # 6
The preparation method of the freckle removing paste 6# is the same as that of the freckle removing paste 1# except that: freckle removing cream No. 6 uses Poria instead of semen Armeniacae amarum.
Comparative example 4 preparation of freckle removing paste No. 7
The preparation method of the freckle removing paste 7# is the same as that of the freckle removing paste 1# except that: lithargyrum is used to replace Notoginseng radix in freckle removing paste No. 7.
Comparative example 5 preparation of freckle removing cream # 8
The freckle removing cream No. 8 is the same as freckle removing cream No. 1 in raw material composition and parts, and is different from the following components in that: freckle removing paste No. 8A, the concentrated mixture obtained in the step (4) is made into strips with the length of 1cm, the height of 2mm and the width of 3mm, and the strips are mixed with the paste obtained in the step (1).
Example 4 Experimental characterization
1. Assay for the inhibition of the Activity of the enzyme
Respectively taking 1# -8#5mg of freckle removing cream, respectively adding water to dilute to 1mg/ml, respectively adding an equal amount of phosphate buffer solution with the pH value of 6.8 and an equal amount of 0.15% of leucine solution, fully and uniformly mixing, incubating at 28 ℃ for 10min, respectively adding an equal amount of 800u/mg of leucine enzyme solution, incubating at 28 ℃ for 10min, transferring to a cuvette, and measuring the absorbance at 475 nm.
And then calculating the inhibition rate of the neuraminidase by using the absorbance of each group, wherein the calculation formula is as follows:
TABLE 1 inhibition of each group of neuraminidases
The result shows that the freckle removing cream No. 1-3 prepared by the raw materials and the method defined by the application has obvious inhibition effect on the tyrosinase, and the inhibition rate is over 80 percent.
Modified chitosan is not used in the freckle removing cream No. 4, and the final result shows that the freckle removing cream has low inhibition rate on the tyrosinase; the method for modifying chitosan in freckle removing cream No. 5 is different from that in example 1, and the final inhibition rate of the chitosan on the tyrosinase is general; the Chinese herbal medicine components in the freckle removing paste No. 6-7 are different from those in the freckle removing paste No. 1, and the inhibition rate of the compound preparation on the tyrosinase is low finally; the freckle removing paste No. 8 is prepared by processing the concentrated mixture into strips, and finally has lower inhibition rate on the neuraminidase.
2. Detection of freckle-removing effect
Selecting 80 patients with freckles, dividing the patients into 8 groups, wherein each group comprises 10 patients, and each face of each patient is provided with 5 freckles with similar sizes; the 1-8 groups are applied with freckle-removing ointment No. 1-8, and the patient is applied with 5g of ointment on the freckle every day for one week. The removal rate of freckles was calculated and skin damage was examined and the results are shown in table 2.
TABLE 2 freckle removal rate and skin damage detection
The result shows that the freckle removing cream prepared by the raw materials and the method has good freckle removing effect, high effect taking speed, removal rate of over 80 percent, no corrosive damage to skin, no stimulation to skin and certain whitening and beautifying effects.
The above description is only an example of the present application, and the protection scope of the present application is not limited by these specific examples, but is defined by the claims of the present application. Various modifications and changes may occur to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the technical idea and principle of the present application should be included in the protection scope of the present application.
Claims (10)
1. The Chinese herbal medicine freckle-removing paste is characterized by comprising the following raw materials in parts by weight: 50-90 parts of almond, 40-80 parts of pseudo-ginseng, 30-70 parts of watermelon seed, 20-60 parts of coix seed, 20-60 parts of pearl powder, 20-60 parts of Chinese waxgourd seed, 10-50 parts of saffron and 60-100 parts of modified chitosan.
2. The Chinese herbal medicine freckle-removing paste according to claim 1 is characterized by comprising the following raw materials in parts by weight: 50-70 parts of almond, 40-60 parts of pseudo-ginseng, 30-50 parts of watermelon seed, 20-40 parts of coix seed, 20-40 parts of pearl powder, 20-40 parts of Chinese waxgourd seed, 10-30 parts of saffron and 60-80 parts of modified chitosan.
3. The Chinese herbal medicine freckle-removing paste according to claim 1 is characterized by being prepared from the following raw materials in parts by weight: 50-70 parts of almond, 40-60 parts of pseudo-ginseng, 30-50 parts of watermelon seed, 20-40 parts of coix seed, 20-40 parts of pearl powder, 20-40 parts of Chinese waxgourd seed, 10-30 parts of saffron and 60-80 parts of modified chitosan.
4. The Chinese herbal medicine freckle-removing paste according to claim 1 is characterized by being prepared from the following raw materials in parts by weight: 60 parts of almond, 50 parts of pseudo-ginseng, 40 parts of watermelon seed, 30 parts of coix seed, 30 parts of pearl powder, 30 parts of Chinese waxgourd seed, 20 parts of saffron and 70 parts of modified chitosan.
5. The Chinese herbal medicine freckle-removing paste according to claim 1, wherein the modified chitosan is prepared from carboxymethyl chitosan, a modifier and sodium borohydride.
6. The Chinese herbal medicine freckle-removing paste according to claim 5, wherein the modifier is trimethylpyruvic acid and/or pyruvic acid.
7. The Chinese herbal medicine freckle-removing paste according to claim 5, wherein the modified chitosan is prepared by mixing carboxymethyl chitosan with water, adding a modifier, stirring for 2-3h, adding a sodium borohydride solution, stirring for 1-3h, filtering, washing and drying to obtain the modified chitosan.
8. A method for preparing the Chinese herbal medicine freckle removing paste according to any one of claims 1 to 7, which is characterized by comprising the following steps:
(1) mixing semen Citrulli, Coicis semen and semen Benincasae, placing in a decocting pot, decocting in water, filtering to obtain first decoction, adding the first decoction into a vacuum concentrator, heating and concentrating under stirring, and collecting paste;
(2) mixing Notoginseng radix and stigma croci Sativi, placing in a decocting pot, decocting in water, and filtering to obtain a second decoction;
(3) adding almond, pearl powder and modified chitosan into a pulverizer, pulverizing and sieving to obtain first mixed powder;
(4) adding the second decoction into a vacuum concentrator, adding the first mixed powder, stirring, heating, concentrating, cooling, and crushing to obtain second mixed powder;
(5) and (3) adding the second mixed powder into the paste prepared in the step (1), and uniformly stirring to obtain the Chinese herbal medicine freckle removing paste.
9. The Chinese herbal medicine freckle-removing paste according to claim 8, wherein the decocting time in the step (1) and the decocting time in the step (2) are both 1-2 hours, the water adding amount in the step (1) is 4-6 times of the total amount of the Chinese herbal medicines in the step, and the water adding amount in the step (2) is 5-8 times of the total amount of the Chinese herbal medicines in the step;
the stirring speed in the step (1) and the step (5) is 30-40r/min, and the stirring speed in the step (4) is 100-150 r/min.
10. The Chinese herbal medicine freckle-removing paste according to claim 9, wherein the heating temperature in the step (1) and the heating temperature in the step (2) are both 80-90 ℃, the heating temperature in the step (4) is 70-90 ℃, and the vacuum heating time is 0.2-0.4 h; sieving in the step (3) by using a sieve of 150-;
concentrating in the step (1) until the relative density of the paste is 1.2-1.4; and (4) concentrating until the relative density of the mixture is 1.2-1.5.
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Application publication date: 20220426 |