CN114129478B - Application of cortex cinnamomi japonici extract in shampoo - Google Patents

Abstract

The invention discloses application of a cortex cinnamomi extract in shampoo, wherein the cortex cinnamomi extract is obtained by extracting cortex cinnamomi, and the cortex cinnamomi extract is added into the shampoo. The extract of cortex Cinnamomi can inhibit the mass growth of malassezia and staphylococci, maintain scalp lipid secretion and scalp metabolism balance, and can not damage scalp cells, thereby fundamentally improving scalp and hair quality. The extraction process of the cortex cinnamomi japonici extract is simple, the raw materials are easy to obtain, the cost is low, the preparation method is safe and reliable, the performance is mild, no adverse reaction exists, the effects of removing dandruff and relieving itching, preventing hair breakage and hair blacking are achieved, complex production equipment is not needed, industrial production can be realized, and popularization is facilitated.

Description

Application of cortex cinnamomi japonici extract in shampoo

Technical Field

The invention belongs to the technical field of daily chemical products, and particularly relates to application of a cortex cinnamomi extract in shampoo.

Background

Shampoo has become a necessity for daily life of people, and the shampoo on the market is various, but most shampoos can not improve hair quality fundamentally, and can not remove dandruff and relieve itching and promote hair growth fundamentally.

Three major balances exist in the scalp that maintain the scalp's ecological environment: 1. flora: when a great amount of malassezia on the scalp grows, the phenomenon of itching of the head occurs; 2. grease: imbalance in scalp oil secretion can lead to greasy scalp, which in turn produces a large amount of malassezia; 3. metabolic balance: the horny layer of the scalp is metabolized too fast to cause the horny layer to peel off and fall off, so that the phenomenon of dandruff and itching occurs.

Along with the development of economy, the life rhythm is accelerated, the pressure is increased greatly, and the human body is in immune dysfunction. In addition, at present, hair follicles on the head are damaged by scalding, dyeing, hair pulling and the like, and phenomena such as alopecia and the like are easy to occur.

The shampoo in the market mainly has the effects of removing dandruff and relieving itching by adding antibacterial agents such as zinc pyrithione, ketoconazole, ganciclovir and piroctone olamine, but zinc-containing compounds such as zinc pyrithione can kill harmful fungi and normal scalp cells, and damage the scalp; ketoconazole has a strong anti-inflammatory effect, but long-term use leads to the generation of diseases such as hyperglycemia, corktion syndrome, urine glucose and the like; however, the glycyrhizin, piroctone olamine and the like cause scalp allergy and unbalance scalp grease secretion.

Cortex Cinnamomi is a plant of genus Lauraceae, class dicotyledoneae, and is grown in evergreen broad-leaved forest. The cortex cinnamomi contains a large amount of flavonoid compounds, alpha-pyrone compounds, alkaloid compounds, lignan compounds and other compounds, and the compounds show various biological activities.

Disclosure of Invention

In view of the above prior art, an object of the present invention is to provide the use of cinnamomum japonicum extract in shampoos; the extract of cortex Cinnamomi can inhibit the proliferation of malassezia and staphylococci, maintain scalp lipid secretion and scalp metabolism balance, prevent hair breakage and hair blackening, and can not cause damage to scalp cells, thereby fundamentally improving scalp and hair quality.

Furthermore, the shampoo is mainly used for removing dandruff, relieving itching and promoting hair growth.

It is another object of the present invention to provide a shampoo comprising an extract of cinnamomum cassia.

Further, the cortex cinnamomi japonici extract accounts for 0.1-10% of the shampoo by weight.

Further, the extraction process of the cortex cinnamomi japonici extract is as follows:

pulverizing trunk, branch and/or root of cortex Cinnamomi, adding solvent, heating to pasty mixture, and filtering to remove residue.

Further, the solvent includes a first solvent and a second solvent.

Further, the first solvent is used for repeatedly extracting, the extracting mixed solution is combined, the evaporation and concentration are reduced, the water is added for dilution, the stirring is carried out, the second solvent is used for extracting, the extracting mixed solution is combined, the evaporation and concentration are reduced, and the mixture is heated to be a viscous mixture.

The extraction method can effectively extract more effective active ingredients and obtain the effective active substances with higher purity by extracting under the first solvent and then extracting under the second solvent.

Preferably, the first solvent is one or more of water, methanol, ethanol, chloroform, diethyl ether.

Preferably, the second solvent is one or more of water, ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone.

Further, the repeated extraction with the first solvent is performed 3 times; the repeated extraction for 3 times is used for extracting more effective nutrients from the cassia bark.

Further, the extracting with the second solvent is performed 5 times; the extraction is repeated for 5 times to improve the purity of the cortex cinnamomi japonici extract.

Still another object of the present invention is to provide a method for preparing the shampoo, comprising the steps of:

mixing the auxiliary raw materials, adding the cortex cinnamomi japonici extract, stirring uniformly, cooling, and then regulating pH and viscosity to obtain the shampoo.

Further, the auxiliary raw materials comprise the following components in parts by weight: 10-15% of surfactant, 0.08-0.12% of preservative, 0.5-2% of viscosity regulator, 1-2.5% of humectant, 0.1-0.5% of pH regulator, 0.2-0.8% of essence and 65-85% of deionized water.

Further, the surfactant is palm kernel oil diethanolamide.

Further, the preservative is pinocembrane.

Further, the viscosity regulator is sodium chloride.

Further, the humectant is capric triglyceride.

Further, the pH regulator is citric acid.

Further, the essence is natural essence.

The scalp of human body is distributed with a plurality of microorganisms, which mainly comprise staphylococcus, propionibacterium and malassezia. Propionibacterium can inhibit dandruff, staphylococcus can cause dandruff, and Malachite has pathogenic effect on scalp. Malassezia belongs to anaerobic fungi with lipase activity, can generate oleic acid and stimulate the release of inflammatory cytokines, destroy the compact structure of scalp cuticle cells and intercellular lipid layers, obviously thin the thickness of the scalp cuticle of a human body, destroy the barrier function of the scalp, and cause the repeated generation of dandruff and the shedding of hair. Propionibacterium bacteria can inhibit the proliferation of staphylococci by secreting related bacteriocins, whereas staphylococci can inhibit the proliferation of Propionibacterium by metabolizing glycerol, and when the balance between the two is disrupted, dandruff is produced. The scalp is provided with rich nutrition sources for propagation of malassezia due to high mental stress, poor eating habits and excessive sebum secretion caused by in vivo hormone changes, and the propagation of the malassezia caused by excessive sebum secretion is promoted, so that the lipophilic malassezia existing in a small amount on the scalp is promoted to propagate, the malassezia on the scalp breaks down triglyceride and saturated fatty acid in the sebum into unsaturated fatty acid through secretion lipase, and the unsaturated fatty acid has pro-inflammatory property and can permeate into the stratum corneum of the scalp to cause itching of the scalp, and on the other hand, calcium ions can flow into scalp cells to further cause excessive keratinization of the scalp keratinocytes, so that dandruff generation and alopecia are accelerated. In addition, the oil on the scalp is easily oxidized by ultraviolet rays to generate lipid peroxide, and the scalp is further stimulated to secrete more sebum.

The cortex Cinnamomi contains a large amount of flavonoids, alpha-pyrones, alkaloids and lignans, and has antibacterial and antiinflammatory effects. During the research and development process, the inventor finds that the extract obtained by extracting the cinnamomum monocarum with the solvent can effectively inhibit the propagation of staphylococcus and malassezia. Can be flavonoid compounds, alpha-pyrone compounds, alkaloid compounds and lignan compounds act on the division of staphylococcus and malassezia, reduce the generation of unsaturated fatty acid and protect the barrier function of scalp. In addition, the extract of the cinnamomum kansui is applied to the preparation of shampoo, and the prepared shampoo has the effects of removing dandruff, relieving itching, preventing hair breakage, removing hair and blackening hair, while other cinnamomum kansui plants have no such effects.

Compared with the prior art, the invention has the following beneficial effects:

(1) In the invention, the cortex cinnamomi japonici is extracted to obtain the mucilage-like extract, which can be directly added into shampoo and is different from the forms of other plant extracts.

(2) The extract of cortex Cinnamomi with water is in viscous form, and the mucus has effects of moistening scalp, and can be used for relieving itching; the mucus can wrap the hair to prevent the hair from breaking, thereby preventing hair from falling; the mucus can also adhere to the white hair to continuously deliver nutrition, and promote the white hair to turn black hair.

(3) The extraction process of the cortex cinnamomi japonici extract is simple, the raw materials are easy to obtain, the cost is low, the preparation method is safe and reliable, the performance is mild, no adverse reaction exists, the effects of removing dandruff and relieving itching, preventing hair breakage and hair blacking are achieved, complex production equipment is not needed, industrial production can be realized, and popularization is facilitated.

Detailed Description

In order to make the technical solution of the present invention better understood by those skilled in the art, the technical solution of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, shall fall within the scope of the present invention.

Example 1

The extraction process of the cortex cinnamomi japonici extract comprises the following steps: pulverizing trunk and branch of sun-dried cortex Cinnamomi (10 kg), extracting with 95% industrial ethanol and diethyl ether respectively for 3 times at room temperature, soaking for 3 days each time, mixing extractive solutions, concentrating under reduced pressure to recover ethanol and diethyl ether to obtain crude product, adding appropriate amount of water into the crude product, ultrasonic stirring, extracting with ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone for 5 times respectively, mixing extractive solutions, concentrating under reduced pressure, recovering ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone, heating the obtained mixture to mucus, and filtering to remove residue to obtain cortex Cinnamomi extract.

Example 2

The extraction process of the cortex cinnamomi japonici extract comprises the following steps: pulverizing trunk and branch of sun-dried cortex Cinnamomi (10 kg), extracting with water at room temperature for 3 times, soaking for 3 days, mixing the above mixed solutions, concentrating under reduced pressure, reducing water content, ultrasonic stirring, extracting with ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether, and acetone for 5 times, mixing the extractive mixed solutions, concentrating under reduced pressure, recovering ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether, and acetone, heating the obtained mixture to mucus, and filtering to remove residue.

Example 3

The extraction process of the cortex cinnamomi japonici extract comprises the following steps: pulverizing trunk and branch of sun-dried cortex Cinnamomi (10 kg), extracting with water at room temperature for 3 times, soaking for 3 days each time, mixing the mixed solutions, concentrating under reduced pressure, reducing water content, ultrasonic stirring, extracting with water for 5 times, mixing the extracted mixed solutions, heating the obtained mixture to mucus, and filtering to remove residue to obtain cortex Cinnamomi extract.

The embodiment provides application of the cortex cinnamomi japonici extract in shampoo.

Example 4

Fully mixing palm kernel oil diethanolamide 12 kg, pinus koraiensis 0.1 kg, capric triglyceride 2 kg, natural essence 0.5 kg and deionized water 83.4 kg, adding the cortex Cinnamomi extract 0.1 kg prepared in example 1, stirring uniformly, cooling, and adding sodium chloride 1.5 kg and citric acid 0.4 kg to obtain shampoo.

Example 5

Fully mixing palm kernel oil diethanolamide 12 kg, pinus koraiensis 0.1 kg, capric triglyceride 2 kg, natural essence 0.5 kg and deionized water 78 kg, adding the cortex Cinnamomi extract 5.5 kg prepared in example 1, stirring uniformly, cooling, and adding sodium chloride 1.5 kg and citric acid 0.4 kg to obtain shampoo.

Example 6

Fully mixing palm kernel oil diethanolamide 12 kg, pinus koraiensis 0.1 kg, capric triglyceride 2 kg, natural essence 0.5 kg and deionized water 73.5 kg, adding the cortex Cinnamomi extract 10 kg prepared in example 1, stirring uniformly, cooling, and adding sodium chloride 1.5 kg and citric acid 0.4 kg to obtain shampoo.

Example 7

Fully mixing palm kernel oil diethanolamide 12 kg, pinus koraiensis 0.1 kg, capric triglyceride 2 kg, natural essence 0.5 kg and deionized water 78 kg, adding the cortex Cinnamomi extract 5.5 kg prepared in example 2, stirring uniformly, cooling, and adding sodium chloride 1.5 kg and citric acid 0.4 kg to obtain shampoo.

Example 8

Fully mixing palm kernel oil diethanolamide 12 kg, pinus koraiensis 0.1 kg, capric triglyceride 2 kg, natural essence 0.5 kg and deionized water 78 kg, adding the cortex Cinnamomi extract 5.5 kg prepared in example 3, stirring uniformly, cooling, and adding sodium chloride 1.5 kg and citric acid 0.4 kg to obtain shampoo.

Comparative example 1

Commercial shampoo

And (5) testing performance.

And (3) antibacterial effect test:

(1) Preparation of the culture medium:

10g of olive oil, 10g of glucose, 5g of peptone, 8.5g of agar, 5g of yeast extract, 0.05g of chloramphenicol and 500mL of distilled water are mixed, heated and boiled for 5 times, sterilized, and cultured under the sterile environment at 4 ℃ for later use.

(2) Preparation of the plates:

inoculating a Malassezia furfur strain and a staphylococcus furfur strain on a culture medium respectively, culturing at a constant temperature of 37 ℃ for 5 days, eluting colonies by using normal saline, preparing bacterial suspensions of 105 cfu/mL-106 cfu/mL respectively, respectively taking 0.5mL of bacterial suspensions to smear on a Leemung & Notman culture medium plate of 12cm, standing for 15min, and drying the plate by wind under aseptic conditions.

(3) Determination of bacteriostatic effect:

taking qualitative filter paper sheets, punching the qualitative filter paper sheets into round filter paper sheets with the diameter of 5mm, sterilizing, drying, respectively taking a small amount of shampoo water obtained in examples 4-8 and comparative example 1, dripping the shampoo water obtained in examples 4-8 and comparative example 1 on the filter paper sheets, respectively attaching the filter paper sheets respectively containing the shampoo water obtained in examples 4-8 and comparative example 1 on a flat plate, culturing the filter paper sheets in a constant temperature incubator at 32 ℃ for 7 days, and measuring the diameter of a bacteriostasis ring, wherein the result is shown in table 1.

Table 1. Antibacterial properties test results of shampoos prepared in examples 4 to 8 and comparative example 1.

As can be seen from Table 1, the extract of Pimenta racemosa has good antibacterial effect against Staphylococcus and Malachillea.

Hair regeneration performance test:

the left and right sides of the spinal column of 70 mice of each male and female half are dehaired, and the dehaired surface area is 10% of the body surface area of the mice. Blank, examples 4-8, and comparative example 1 10 mice each in half. Blank control group: distilled water was applied to the right side of each mouse, examples 4-8: the right side of each mouse was coated with 0.5g/ml of the shampoos prepared in examples 4-8, comparative example 1 group: the right side of each mouse was overcoated with 0.5g/ml of the shampoo prepared in comparative example 1. The left regions of each group were not treated. Mice were sacrificed 10 days after continuous dosing. The skin on the left and right sides of the spinal column of each mouse was stained, the change in the total layer of skin and the number of hair follicles of each mouse was observed under a microscope, the change in the average number of cells of the hair follicles of the epidermis and the change in the number of layers of the epidermis were recorded for each group of mice, the skin tissue of 1cm×1cm was used as the precursor for measurement, and the results are shown in table 2.

Table 2. Hair regeneration performance test results of the shampoos prepared in examples 4 to 8 and comparative example 1.

As is clear from Table 2, compared with the blank control group and the comparative example 1, the shampoo prepared in examples 4 to 8 acts on the skin of the mice, the average number of the epidermal hair follicle cells and the number of the epidermal layers are obviously increased, which proves that the shampoo prepared in examples 4 to 8 has good regulation effect on the nerve and blood circulation of the skin hair follicle, and is beneficial to the regeneration of hair.

Anti-dandruff and antipruritic performance test:

264 volunteers with symptoms of dandruff and scalp itching, with ages 18-65, were selected on average, randomly divided into 6 groups, 44 persons in each group, and shampoo prepared in examples 4-8 and comparative example 1 was used for each group, and shampoo was used once daily, the time period was the same, and after continuous use for 7 days, the use effect of the volunteers was observed and counted, and the results are shown in table 3.

Evaluation criteria: is very effective: the scalp is not itchy any more and the dandruff is basically disappeared; the comparison is effective: relieving scalp itching and dandruff; invalidation: scalp itching and dandruff symptoms were not improved.

Effective rate= (very effective + relatively effective) number of people/number of tested person x 100%.

Table 3. The shampoo prepared in examples 4-8 and comparative example 1 was tested for anti-dandruff and antipruritic properties.

As is clear from Table 3, the shampoos prepared in examples 4 to 8 have good anti-dandruff and antipruritic effects as compared with the commercially available shampoos.

Irritation and allergy test:

the backs of 140 mice of the male and female halves were shaved and the backs were washed with distilled water, and the shaved surface area was 10% of the body surface area of the mice. Blank, examples 4-8, and comparative example 1 groups of 20 mice each in hermaphroditic half. Blank control group: distilled water was applied to the backs of the mice, respectively, for groups 4-8: shampoo prepared in examples 4-8 was applied to the backs of the mice, respectively, and comparative example 1 group: the back of each mouse was respectively coated with the shampoo prepared in comparative example 1. After 1 hour, each mouse was washed with warm water, and the presence or absence of erythema or edema on the skin of the mouse was observed continuously over 24 hours. The results are shown in Table 4.

Evaluation criteria: severe allergy: severe erythema and edema; mild allergy: slight erythema and edema appear; no allergy: no erythema and edema occurred.

No allergy rate = no allergy/number of mice tested x 100%.

Table 4. Allergy test results of shampoos prepared in examples 4-8 and comparative example 1.

As can be seen from Table 4, the addition of the Pimenta extract to the shampoo showed no allergic condition.

In conclusion, the cortex cinnamomi extract is safe and reliable, has mild performance and no adverse reaction, has good effects of removing dandruff, relieving itching and promoting hair growth, and can be industrially produced.

Finally, it should be noted that the above-mentioned embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the above-mentioned embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made to the specific embodiments of the present invention after reading the present specification, and these modifications and variations do not depart from the scope of the invention as claimed in the pending claims.

Claims (3)

1. A shampoo, which is characterized in that: comprises cortex Cinnamomi extract; the weight ratio of the cortex cinnamomi japonici extract to the shampoo is 0.1-10%; the extraction process of the cortex cinnamomi japonici extract is as follows:

pulverizing trunk, branch and/or root of cortex Cinnamomi, adding solvent, heating to pasty mixture, and filtering to remove residue;

the solvent includes a first solvent and a second solvent;

the first solvent is one or more of water, methanol, ethanol, chloroform and diethyl ether;

the second solvent is one or more of water, ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone.

2. The shampoo of claim 1, wherein: repeatedly extracting with first solvent, mixing the extractive solutions, concentrating by evaporation, diluting with water, stirring, extracting with second solvent, mixing the extractive solutions, concentrating by evaporation, and heating to obtain a pasty mixture.

3. The shampoo of claim 1, wherein: the preparation method of the shampoo comprises the following steps:

mixing the auxiliary raw materials, adding the cortex cinnamomi japonici extract, stirring uniformly, cooling, and then regulating pH and viscosity to obtain the shampoo.