CN114316405A - Medical tube and preparation method thereof - Google Patents
Medical tube and preparation method thereof Download PDFInfo
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- CN114316405A CN114316405A CN202111644442.6A CN202111644442A CN114316405A CN 114316405 A CN114316405 A CN 114316405A CN 202111644442 A CN202111644442 A CN 202111644442A CN 114316405 A CN114316405 A CN 114316405A
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- 238000002360 preparation method Methods 0.000 title description 9
- 239000000463 material Substances 0.000 claims abstract description 24
- 229920001684 low density polyethylene Polymers 0.000 claims abstract description 20
- 239000004702 low-density polyethylene Substances 0.000 claims abstract description 20
- 229920001179 medium density polyethylene Polymers 0.000 claims abstract description 18
- 239000004701 medium-density polyethylene Substances 0.000 claims abstract description 18
- 229920000098 polyolefin Polymers 0.000 claims abstract description 14
- 229920002725 thermoplastic elastomer Polymers 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000000314 lubricant Substances 0.000 claims abstract description 4
- 229940073609 bismuth oxychloride Drugs 0.000 claims description 15
- BWOROQSFKKODDR-UHFFFAOYSA-N oxobismuth;hydrochloride Chemical compound Cl.[Bi]=O BWOROQSFKKODDR-UHFFFAOYSA-N 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 14
- 229910000416 bismuth oxide Inorganic materials 0.000 claims description 12
- TYIXMATWDRGMPF-UHFFFAOYSA-N dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Bi+3].[Bi+3] TYIXMATWDRGMPF-UHFFFAOYSA-N 0.000 claims description 12
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 12
- 229920006244 ethylene-ethyl acrylate Polymers 0.000 claims description 12
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 229910000014 Bismuth subcarbonate Inorganic materials 0.000 claims description 9
- MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 claims description 9
- 229940036358 bismuth subcarbonate Drugs 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 229920001577 copolymer Polymers 0.000 claims description 8
- 238000005469 granulation Methods 0.000 claims description 7
- 230000003179 granulation Effects 0.000 claims description 7
- 238000005303 weighing Methods 0.000 claims description 7
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 6
- 239000008116 calcium stearate Substances 0.000 claims description 6
- 235000013539 calcium stearate Nutrition 0.000 claims description 6
- UAUDZVJPLUQNMU-UHFFFAOYSA-N Erucasaeureamid Natural products CCCCCCCCC=CCCCCCCCCCCCC(N)=O UAUDZVJPLUQNMU-UHFFFAOYSA-N 0.000 claims description 4
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 4
- 235000021355 Stearic acid Nutrition 0.000 claims description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 4
- UAUDZVJPLUQNMU-KTKRTIGZSA-N erucamide Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(N)=O UAUDZVJPLUQNMU-KTKRTIGZSA-N 0.000 claims description 4
- 239000000155 melt Substances 0.000 claims description 4
- RKISUIUJZGSLEV-UHFFFAOYSA-N n-[2-(octadecanoylamino)ethyl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCCNC(=O)CCCCCCCCCCCCCCCCC RKISUIUJZGSLEV-UHFFFAOYSA-N 0.000 claims description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 4
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 4
- 239000008117 stearic acid Substances 0.000 claims description 4
- 229940036359 bismuth oxide Drugs 0.000 claims description 2
- 239000012216 imaging agent Substances 0.000 claims 3
- 238000011084 recovery Methods 0.000 abstract description 7
- 229920001971 elastomer Polymers 0.000 abstract description 2
- 239000000806 elastomer Substances 0.000 abstract description 2
- 239000011159 matrix material Substances 0.000 description 5
- 238000007493 shaping process Methods 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 3
- 238000001000 micrograph Methods 0.000 description 3
- 210000000013 bile duct Anatomy 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012805 post-processing Methods 0.000 description 2
- 241000191291 Abies alba Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 229940036348 bismuth carbonate Drugs 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- GMZOPRQQINFLPQ-UHFFFAOYSA-H dibismuth;tricarbonate Chemical compound [Bi+3].[Bi+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GMZOPRQQINFLPQ-UHFFFAOYSA-H 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000000635 electron micrograph Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
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- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The application provides a medical tube which is characterized by comprising the following raw materials in parts by weight: 30 to 50 portions of low-density polyethylene, 10 to 30 portions of medium-density polyethylene, 5 to 30 portions of polyolefin thermoplastic elastomer, 15 to 40 portions of developer and 0.01 to 0.5 portion of lubricant. The base material of the medical tube is low-density polyethylene, medium-density polyethylene and polyolefin thermoplastic elastomer, the polyolefin thermoplastic elastomer can ensure the high elasticity of the material, the addition of the medium-density polyethylene can increase the strength and hardness of the base materials of the low-density polyethylene and the elastomer, and the three have good compatibility, so that the surface of a formed product has a low friction coefficient and excellent smoothness, and the formed product also has high elasticity recovery performance while ensuring the hardness range to be 49D-53D.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a medical tube and a preparation method thereof.
Background
In the field of interventional medical catheters, catheters with developing requirements, such as a nasal biliary drainage tube, a urethral drainage tube and the like, have certain requirements on elastic recovery performance, hardness, surface smoothness and developing effect in use. For example, because the nasal biliary drainage tube needs to meet two requirements of placing one end of the duct into the bile duct to prevent dropping and draining bile, the end of the duct placed into the bile duct must be shaped and perforated.
The common shaping shapes of the end part of the conduit comprise a pigtail type, a pigtail alpha type, a pigtail inverse alpha type, a Christmas tree type and the like. In use, the metal guide wire first reaches the lesion site, after which the catheter is threaded into the guide wire, guided by the guide wire, to reach the lesion site. During the process of the catheter penetrating into the guide wire, the shaping position can deform under the action of the guide wire. When the catheter reaches the lesion position, the guide wire is drawn out, and the shape of the catheter is restored to the shape. In the use process, after the guide wire is drawn out, if the elastic recovery performance of the tube is poor and the tube is difficult to recover to the shape during shaping, the use effect is influenced, and the operation process is seriously delayed. The hardness of a catheter for developing which is required to be left in a human body for a certain period of time or for post-processing such as punching is generally about 49-53D. The hardness is too soft, which is not beneficial to pushing when the catheter enters the human body in the use process and post-processing; the hardness is too hard, which affects the use feeling of patients and can cause harm to human bodies.
The medical catheters on the market at present have poor elastic recovery performance, and are difficult to recover to the shape before shaping after the guide wire is drawn out of the catheter.
Disclosure of Invention
The application provides a medical tube and a preparation method thereof, which can greatly improve the resilience rate of the medical tube while ensuring the hardness and the developing function of a catheter made of the medical tube.
In a first aspect, a medical tube is provided, and raw materials thereof comprise the following components in parts by weight:
optionally, the polyolefin thermoplastic elastomer comprises one or more of an ethylene-vinyl acetate copolymer, an ethylene-ethyl acrylate copolymer, and an ethylene-octene copolymer.
Optionally, the polyolefin thermoplastic elastomer comprises an ethylene-vinyl acetate copolymer, and the vinyl acetate content of the ethylene-vinyl acetate copolymer is 7.5% to 25%.
Optionally, the polyolefin thermoplastic elastomer comprises an ethylene-ethyl acrylate copolymer, and the content of ethyl acrylate in the ethylene-ethyl acrylate copolymer is 5% to 12%.
Optionally, the polyolefin thermoplastic elastomer comprises an ethylene-octene copolymer having a hardness of 80A to 90A.
Optionally, the developer includes one or more of bismuth oxychloride, bismuth oxide, and bismuth subcarbonate.
Optionally, the developer comprises bismuth oxychloride, the bismuth oxychloride is in a sheet shape, the particle size D50 of the bismuth oxychloride is 1-20 micrometers, the thickness of the bismuth oxychloride is 0.02-1.4 micrometers, and the diameter-thickness ratio of the bismuth oxychloride is 15-35.
Optionally, the developer includes bismuth oxide, the bismuth oxide being spherical in shape and having a particle size D50 of 0.5 microns to 5 microns.
Optionally, the developer comprises bismuth subcarbonate, the bismuth subcarbonate is flaky, the particle size D50 of the bismuth subcarbonate ranges from 0.5 microns to 10 microns, the thickness ranges from 0.02 microns to 1 micron, and the diameter-thickness ratio ranges from 10 microns to 30.
Optionally, the lubricant comprises one or more of ethylene bis stearamide, stearic acid, calcium stearate and erucamide.
Optionally, the low density polyethylene has a melt index in the range of 0.5g to 5g/10min and a hardness in the range of 45D to 52D.
Optionally, the medium density polyethylene has a melt index in the range of 0.2g to 3g/10min and a hardness in the range of 55D to 62D.
Optionally, the medical tubing has a hardness in the range of 49D to 53D.
In a second aspect, a method for preparing a medical tube is provided, which comprises the following steps:
s1: weighing the components in parts by weight;
s2: mixing the components by a V-shaped material mixer for 20-30 min;
s3: and (2) carrying out melt blending granulation on the mixed materials through a double-screw extruder, wherein the extruder is divided into six zones, and the temperatures of the six zones are respectively as follows: the temperature of the first area is 150-160 ℃, the temperature of the second area is 160-170 ℃, the temperature of the third area is 170-180 ℃, the temperature of the fourth area is 170-180 ℃, the temperature of the fifth area is 180-190 ℃, and the temperature of the sixth area is 185-195 ℃.
The base material of the medical tube is low-density polyethylene, medium-density polyethylene and polyolefin thermoplastic elastomer, the polyolefin thermoplastic elastomer can ensure the high elasticity of the material, the addition of the medium-density polyethylene can increase the strength and hardness of the low-density polyethylene and the elastomer base material, and the three have good compatibility, so that the surface of a formed product has a low friction coefficient and excellent smoothness, and the formed product also has high elasticity recovery performance while ensuring the hardness range to be 49D-53D and the developing function.
Drawings
FIG. 1 is a 3000 times electron micrograph of the developer dispersion within the catheter matrix made by the method of the present application;
FIG. 2 is a 40000 times electron microscope image of the developer dispersion in the catheter matrix made by the method of the present application.
Detailed Description
The commercially available catheters are generally made of low density polyethylene as the base material, which has good flexibility, extensibility, easy processability and good chemical stability, but the catheters have poor elastic recovery performance and are difficult to recover to the shape before shaping after the guide wire is drawn out of the catheter. The polyolefin thermoplastic elastomer has the characteristics of small density, large bending, high low-temperature impact resistance, easy processing, reusability and the like, but has small hardness and is difficult to maintain and shape. Therefore, there is a need for improvements to existing materials.
The technical solution of the present invention will be more clearly and completely explained by the description of the preferred embodiments of the present invention.
Example 1: the raw materials of the medical tubing comprise 30 kg of low-density polyethylene, 30 kg of medium-density polyethylene, 10 kg of ethylene-vinyl acetate copolymer, 35 kg of bismuth oxychloride and 0.3 kg of calcium stearate;
wherein the content of vinyl acetate in the ethylene-vinyl acetate copolymer is 19 percent, the grain diameter D50 of the bismuth oxychloride is 20 microns, the average thickness is 1.2 microns, and the average diameter-thickness ratio is about 16.7.
The preparation process comprises the following steps:
s1: weighing 30 kg of low-density polyethylene and 30 kg of medium-density polyethylene according to the parts by weight, wherein the low-density polyethylene comprises 10 kg of ethylene-vinyl acetate copolymer, 35 kg of bismuth oxychloride and 0.3 kg of calcium stearate;
s2: mixing the components by a V-shaped material mixer for 5-30 min;
s3: and (2) carrying out melt blending granulation on the mixed materials through a double-screw extruder, wherein the extruder is divided into six zones, and the temperatures of the six zones are respectively as follows: the temperature of the first area is 150-160 ℃, the temperature of the second area is 160-170 ℃, the temperature of the third area is 170-180 ℃, the temperature of the fourth area is 170-180 ℃, the temperature of the fifth area is 180-190 ℃, and the temperature of the sixth area is 185-195 ℃.
Comparative example 1: 40 kg of low-density polyethylene, 30 kg of medium-density polyethylene, 35 kg of developer and 0.3 kg of lubricant.
Example 2: the raw materials of the medical tubing comprise 30 kg of low-density polyethylene, 20 kg of medium-density polyethylene, 10 kg of ethylene-vinyl acetate copolymer, 35 kg of bismuth oxide and 0.01 kg of erucamide.
Wherein the content of vinyl acetate in the ethylene-vinyl acetate copolymer is 10 percent, and the grain diameter D50 of the bismuth oxide is 1 micron.
The preparation process comprises the following steps:
s1: weighing 30 kg of low-density polyethylene, 20 kg of medium-density polyethylene, 10 kg of ethylene-vinyl acetate copolymer, 35 kg of bismuth oxide and 0.01 kg of erucamide according to the weight parts;
s2: mixing the components by a V-shaped material mixer for 5-30 min;
s3: and (2) carrying out melt blending granulation on the mixed materials through a double-screw extruder, wherein the extruder is divided into six zones, and the temperatures of the six zones are respectively as follows: the temperature of the first area is 150-160 ℃, the temperature of the second area is 160-170 ℃, the temperature of the third area is 170-180 ℃, the temperature of the fourth area is 170-180 ℃, the temperature of the fifth area is 180-190 ℃, and the temperature of the sixth area is 185-195 ℃.
Example 3: 30 kg of low-density polyethylene, 30 kg of medium-density polyethylene, 10 kg of ethylene-octene copolymer (brand 8150, manufacturer DOW), 35 kg of bismuth oxychloride and 0.3 kg of calcium stearate.
Wherein the ethylene-octene copolymer has a hardness of 70A, a particle size D50 of the bismuth oxychloride of 20 microns, an average thickness of 1.2 microns, and an average aspect ratio of about 16.7.
The preparation process comprises the following steps:
s1: weighing 30 kg of low-density polyethylene, 30 kg of medium-density polyethylene, 10 kg of ethylene-octene copolymer (brand 8150, manufacturer DOW), 35 kg of bismuth oxychloride and 0.3 kg of calcium stearate according to the weight parts;
s2: mixing the components by a V-shaped material mixer for 5-30 min;
s3: and (2) carrying out melt blending granulation on the mixed materials through a double-screw extruder, wherein the extruder is divided into six zones, and the temperatures of the six zones are respectively as follows: the temperature of the first area is 150-160 ℃, the temperature of the second area is 160-170 ℃, the temperature of the third area is 170-180 ℃, the temperature of the fourth area is 170-180 ℃, the temperature of the fifth area is 180-190 ℃, and the temperature of the sixth area is 185-195 ℃.
Example 4: 30 kg of low-density polyethylene, 20 kg of medium-density polyethylene, 10 kg of ethylene-ethyl acrylate copolymer, 35 kg of bismuth oxide and 0.1 kg of ethylene bisstearamide.
Wherein the content of ethyl acrylate in the ethylene-ethyl acrylate copolymer is 10 percent, and the particle size D50 of the bismuth oxide is 1 micron.
The preparation process comprises the following steps:
s1: weighing 30 kg of low-density polyethylene, 20 kg of medium-density polyethylene, 10 kg of ethylene-ethyl acrylate copolymer, 35 kg of bismuth oxide and 0.1 kg of ethylene bisstearamide in parts by weight;
s2: mixing the components by a V-shaped material mixer for 5-30 min;
s3: and (2) carrying out melt blending granulation on the mixed materials through a double-screw extruder, wherein the extruder is divided into six zones, and the temperatures of the six zones are respectively as follows: the temperature of the first area is 150-160 ℃, the temperature of the second area is 160-170 ℃, the temperature of the third area is 170-180 ℃, the temperature of the fourth area is 170-180 ℃, the temperature of the fifth area is 180-190 ℃, and the temperature of the sixth area is 185-195 ℃.
Example 5: 50 kg of low-density polyethylene, 10 kg of medium-density polyethylene, 28 kg of ethylene-ethyl acrylate copolymer, 16kg of bismuth subcarbonate and 0.05 kg of stearic acid.
Wherein the content of ethyl acrylate in the ethylene-ethyl acrylate copolymer is 20 percent, and the particle size D50 of the basic bismuth carbonate is 2 microns.
The preparation process comprises the following steps:
s1: weighing 50 kg of low-density polyethylene, 10 kg of medium-density polyethylene, 28 kg of ethylene-ethyl acrylate copolymer, 16kg of bismuth subcarbonate and 0.05 kg of stearic acid according to parts by weight;
s2: mixing the components by a V-shaped material mixer for 5-30 min;
s3: and (2) carrying out melt blending granulation on the mixed materials through a double-screw extruder, wherein the extruder is divided into six zones, and the temperatures of the six zones are respectively as follows: the temperature of the first area is 150-160 ℃, the temperature of the second area is 160-170 ℃, the temperature of the third area is 170-180 ℃, the temperature of the fourth area is 170-180 ℃, the temperature of the fifth area is 180-190 ℃, and the temperature of the sixth area is 185-195 ℃.
The performance of examples 1-5 and comparative example 1 was tested, and the results of testing 50 catheters with a pipe resilience testing device of patent No. CN202021999739.5 are shown in Table I:
watch 1
As can be seen from Table I, the hardness of the catheter made of the medical tube material is in the range of 49-53D, the formed radiopaque product has high elastic recovery performance, the average rebound rate can exceed 87 percent and can reach 94.8 percent at most, and the rebound rate is greatly improved while the hardness is ensured.
FIG. 1 is a 3000 times electron microscope image of the developer dispersion condition in the catheter matrix prepared by the method, and FIG. 2 is a 40000 times electron microscope image of the developer dispersion condition in the catheter matrix prepared by the method, and by selecting specific materials and proportions thereof, the good distribution of polyethylene with different densities and the developer with specific microscopic size in the catheter matrix is realized (as shown in FIG. 1 and FIG. 2), and the hardness, resilience and developing performance of the catheter are considered.
The foregoing is merely a preferred embodiment of the present invention, and it should be understood that various changes, modifications, substitutions and alterations can be made herein without departing from the principles and spirit of the invention as defined by the appended claims.
Claims (10)
2. the medical tubing of claim 1, wherein the polyolefin thermoplastic elastomer comprises one or more of ethylene-vinyl acetate copolymer, ethylene-ethyl acrylate copolymer, and ethylene-octene copolymer.
3. The medical tubing of claim 2, wherein the polyolefin thermoplastic elastomer comprises an ethylene-vinyl acetate copolymer, wherein the ethylene-vinyl acetate copolymer has a vinyl acetate content of 7.5% to 25%; alternatively, the first and second electrodes may be,
the polyolefin thermoplastic elastomer comprises an ethylene-ethyl acrylate copolymer, wherein the ethyl acrylate content of the ethylene-ethyl acrylate copolymer is 5-12%; alternatively, the first and second electrodes may be,
the polyolefin thermoplastic elastomer comprises an ethylene-octene copolymer, and the hardness of the ethylene-octene copolymer is 80-90A.
4. The medical tubing of claim 1, wherein the imaging agent comprises one or more of bismuth oxychloride, bismuth oxide, and bismuth subcarbonate.
5. The medical tube as claimed in claim 4, wherein the developer comprises bismuth oxychloride, the bismuth oxychloride is in the shape of a sheet, the particle size D50 is 1-20 microns, the thickness is 0.02-1.4 microns, and the aspect ratio is 15-35.
6. The medical tubing of claim 4, wherein the imaging agent comprises bismuth oxide, wherein the bismuth oxide is spherical in shape and has a particle size D50 of 0.5-5 microns.
7. The medical tubing of claim 4, wherein the imaging agent comprises bismuth subcarbonate, wherein the bismuth subcarbonate is in the shape of a sheet, and has a particle size D50 of 0.5-10 microns, a thickness of 0.02-1 micron, and a aspect ratio of 10-30.
8. The medical tubing of claim 1, wherein the lubricant comprises one or more of ethylene bis stearamide, stearic acid, calcium stearate, and erucamide.
9. The medical tubing of claim 1, wherein the low density polyethylene has a melt index in the range of 0.5g to 5g/10min (190 ℃, 2.16kg), a hardness in the range of 45D to 52D; and/or
The melt index range of the medium density polyethylene is 0.2 g-3 g/10min (190 ℃, 2.16kg), and the hardness range is 55D-62D.
10. The method for preparing a medical tubing according to any one of claims 1-9, comprising the steps of:
s1: weighing the components in parts by weight;
s2: mixing the components by a V-shaped material mixer for 20-30 min;
s3: and (2) carrying out melt blending granulation on the mixed materials through a double-screw extruder, wherein the extruder is divided into six zones, and the temperatures of the six zones are respectively as follows: the temperature of the first area is 150-160 ℃, the temperature of the second area is 160-170 ℃, the temperature of the third area is 170-180 ℃, the temperature of the fourth area is 170-180 ℃, the temperature of the fifth area is 180-190 ℃, and the temperature of the sixth area is 185-195 ℃.
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2021
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