CN114306916B - Body surface noninvasive rapid drug delivery flexible microsystem based on shock wave microjet and method thereof - Google Patents
Body surface noninvasive rapid drug delivery flexible microsystem based on shock wave microjet and method thereof Download PDFInfo
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- CN114306916B CN114306916B CN202111638427.0A CN202111638427A CN114306916B CN 114306916 B CN114306916 B CN 114306916B CN 202111638427 A CN202111638427 A CN 202111638427A CN 114306916 B CN114306916 B CN 114306916B
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Abstract
The invention discloses a body surface noninvasive rapid drug delivery flexible microsystem based on shock wave microjet and a method thereof. The invention uses a semiconductor bridge of an energy-containing system to detonate an energy-containing medicament to generate micro-detonation, generates explosion shock waves to deform an isolation layer and extrudes the medicament in a medicament storage mechanism, so that the liquid medicament penetrates through the skin of a human body to enter the human body in a jet flow mode; the isolation layer has air permeability and ductility, so that not only can the explosion shock wave be transmitted, but also harmful substances generated after the energetic medicament explodes can be intercepted and enter a human body, and the system safety is improved; the invention is in an array patch type, and can meet the requirements of noninvasive, rapid and efficient drug delivery for human bodies by carrying out drug delivery; the invention has low cost and low power consumption, can be used for one time, and reduces the possibility of cross infection of infectious diseases; the isolation layer has gas permeability and ductility, not only can transmit the explosion shock wave, also can intercept simultaneously and contain the harmful substance that produces behind the agent explosion and get into the human body, improves system security nature.
Description
Technical Field
The invention relates to a non-invasive rapid drug delivery technology, in particular to a non-invasive rapid drug delivery flexible microsystem based on shock wave microjet on body surface and an implementation method thereof.
Background
At present, new crown diseases are abused worldwide, chronic diseases such as diabetes and the like continuously threaten human health, and the rapid and convenient medicine delivery to human bodies is very important for preventing and treating various diseases. However, the patient can suffer from bleeding, pain, bruise and the like when the conventional needle is penetrated into the skin to inject the medicine, the needle is not reused, the risk of cross contamination is reduced, the patient can complete injection by himself, and great convenience is brought to the chronic patient with diabetes and the like. Due to the excessive penetration depth and poor ejection efficiency of conventional ejector designs, the human body is often scratched and painful. The method using Lorentz magnetic force live electrophoresis has complex system, high power consumption and is not beneficial to disposable use.
Invention of the invention
In order to solve the problems of non-invasive and rapid drug delivery of a human body and not influencing the functionality and reliability of a shock wave non-invasive drug delivery micro-system so as to realize efficient and safe drug delivery to the human body, the invention provides a shock wave microjet body surface non-invasive and rapid drug delivery flexible micro-system and an implementation method thereof, which can meet the requirements of non-invasive, rapid and efficient drug delivery to the human body, and meanwhile, the system has low cost and low power consumption, can be used for one time, and reduces the possibility of cross infection of infectious diseases.
The invention aims to provide a flexible micro-system for non-invasive rapid drug delivery on body surfaces based on shock wave micro-jet.
The invention relates to a flexible micro-system for noninvasive and rapid drug delivery based on shock wave micro-jet, which comprises: the device comprises a flexible substrate, a medicine storage mechanism mounting groove array, a nozzle hole, a medicine storage mechanism array, an isolation layer, a flexible circuit board, an energy-containing system array, a connecting electrode array and a power supply; the flexible substrate is made of flexible materials; the front surface of the flexible substrate is provided with a plurality of medicine storage mechanism mounting grooves which are arranged in a two-dimensional array to form a medicine storage mechanism mounting groove array, and the bottom surface of each medicine storage mechanism mounting groove is provided with a nozzle hole which is communicated with the back surface of the flexible substrate; a medicine storage mechanism is arranged in each medicine storage mechanism mounting groove, so that a plurality of medicine storage mechanisms are arranged in a two-dimensional array to form a medicine storage mechanism array, and medicines are contained in each medicine storage mechanism; arranging an isolation layer on the medicine storage mechanism array, wherein the isolation layer is made of a material with ductility and air permeability; a plurality of energy-containing systems are welded on the lower surface of the flexible circuit board, each energy-containing system corresponds to one medicine storage mechanism, and therefore the energy-containing systems are arranged in a two-dimensional array to form an energy-containing system array; arranging a plurality of pairs of connecting electrodes on the upper surface of the flexible circuit board, wherein each pair of connecting electrodes corresponds to one energy-containing system, so that the plurality of pairs of connecting electrodes are arranged in a two-dimensional array to form a connecting electrode array, and each energy-containing system is electrically connected to the corresponding connecting electrode; each pair of connecting electrodes is connected to a power supply;
each energetic system comprises a semiconductor bridge, a drug pillar ring and an energetic agent; the semiconductor bridge comprises a semiconductor bridge wire and semiconductor bridge electrodes at two ends of the semiconductor bridge wire; the pair of semiconductor bridge electrodes of each semiconductor bridge are welded on the lower surface of the flexible circuit board and are electrically connected to the corresponding pair of connecting electrodes; each semiconductor bridge corresponds to one medicine storage mechanism, so that a plurality of semiconductor bridges are welded on the lower surface of the flexible circuit board and arranged in a two-dimensional array to form a semiconductor bridge array; arranging a drug column ring below the semiconductor bridge; the drug column ring is a circular flat plate with a through hole in the center; energy-containing medicaments are placed in the through holes of the medicament column rings and are positioned right below the semiconductor bridge wire, so that each energy-containing medicament is aligned with the corresponding medicament storage mechanism;
the back of a flexible substrate of the flexible micro-system for noninvasive and rapid drug delivery based on shock wave microjet is arranged on the surface of human skin, and nozzle holes at the bottom of a drug storage mechanism mounting groove array are tightly attached to the surface of the human skin; switching on a power supply, wherein the power supply applies voltage to a semiconductor bridge of the energy-containing system through a connecting electrode; the semiconductor bridge wire is rapidly heated and gasified to generate an electric explosion effect, the energetic medicament in the explosive column ring is subjected to micro-detonation, and the micro-detonation generates an explosion shock wave; under the action of the explosive shock wave, the isolation layer deforms and extrudes the medicine in the medicine storage mechanism, so that the liquid medicine is ejected from the medicine storage mechanism in a jet flow mode, reaches the skin of a human body through a nozzle hole at the bottom of the medicine storage mechanism mounting groove and permeates the skin of the human body to enter the human body; the isolation layer has gas permeability and ductility, not only can transmit the explosion shock wave, also can intercept simultaneously and contain the harmful substance that produces behind the agent explosion and get into the human body, improves system security nature.
The flexible material adopted by the flexible substrate is rubber, soft silica gel or flexible resin, and the thickness is 6.5-7.5 mm.
The material of the drug column ring is resin or hard rubber, and the height is 0.7-0.9 mm. The energetic medicament adopts copper azide or silver azide, and the mass is 0.35 mg-0.45 mg.
The isolation layer is made of polydimethylsiloxane PDMS film and the thickness of the isolation layer is 0.9-1.1 mm.
The medicine storage mechanism comprises a medicine storage bin and a nozzle; the medicine storage bin is a columnar shell with openings at the top end and the bottom end, nozzles communicated into a whole are arranged at the bottom of the medicine storage bin to form a funnel shape, and the bottom of each nozzle of each medicine storage mechanism is over against a nozzle hole at the bottom surface of the medicine storage mechanism mounting groove; the length of the nozzle is 1.8-2.2 mm. The diameter of the nozzle is 0.6-1.1 mm, so that the liquid medicine cannot flow out when not subjected to explosion shock waves under the action of surface tension.
The semiconductor bridge wire of the semiconductor bridge is made of silicon doped with non-metallic materials; doping with one or more of arsenic, phosphorus and boron at a concentration of 5 × 10 18 ～3×10 20 Ion/cm 3 (ii) a The semiconductor bridge has a length of 1.5mm to 2mm, a width of 0.3mm to 0.5mm, and a thickness of 2 μm to 5 μm.
The power supply adopts a lithium ion battery, and the power supply voltage is 4.5-5.5V. The flexible circuit board adopts polyimide film or polyester film.
The invention also aims to provide a method for realizing the body surface noninvasive rapid drug delivery flexible microsystem based on the shock wave microjet.
The invention discloses a method for realizing a body surface noninvasive rapid drug delivery flexible microsystem based on shock wave microjet, which comprises the following steps:
1) system connection:
a) providing a flexible substrate made of a flexible material;
b) the front surface of the flexible substrate is provided with a plurality of medicine storage mechanism mounting grooves which are arranged in a two-dimensional array to form a medicine storage mechanism mounting groove array, and the bottom surface of each medicine storage mechanism mounting groove is provided with a nozzle hole for opening the back surface of the flexible substrate;
c) placing a medicine storage mechanism in each medicine storage mechanism mounting groove, so that a plurality of medicine storage mechanisms are arranged in a two-dimensional array to form a medicine storage mechanism array, and medicines are contained in each medicine storage mechanism;
d) arranging an isolation layer on the medicine storage mechanism array, wherein the isolation layer is made of a material with ductility and air permeability;
e) welding a plurality of energy-containing systems on the lower surface of the flexible circuit board, wherein each energy-containing system corresponds to one medicine storage mechanism, so that the energy-containing systems are arranged in a two-dimensional array to form an energy-containing system array;
f) arranging a plurality of pairs of connecting electrodes on the upper surface of the flexible circuit board, wherein each pair of connecting electrodes corresponds to one energy-containing system, so that the plurality of pairs of connecting electrodes are arranged in a two-dimensional array to form a connecting electrode array, and each energy-containing system is electrically connected to the corresponding connecting electrode;
g) each pair of connecting electrodes is connected to a power supply;
2) the back surface of a flexible substrate of a flexible micro-system for noninvasive and rapid drug delivery on the body surface based on shock wave micro-jet is arranged on the surface of human skin, and nozzle holes at the bottom of a drug storage mechanism mounting groove array are tightly attached to the surface of the human skin;
3) switching on a power supply, wherein the power supply applies voltage to a semiconductor bridge of the energy-containing system through a connecting electrode;
4) the semiconductor bridge wire is rapidly heated and gasified to generate an electric explosion effect, the energetic medicament in the explosive column ring is subjected to micro-detonation, and the micro-detonation generates an explosion shock wave;
5) under the action of the explosive shock wave, the isolation layer deforms and extrudes the medicine in the medicine storage mechanism, so that the liquid medicine is ejected from the medicine storage mechanism in a jet flow mode, reaches the skin of a human body through a nozzle hole at the bottom of the medicine storage mechanism mounting groove and permeates the skin of the human body to enter the human body;
6) the isolation layer has gas permeability and ductility, not only can transmit the explosion shock wave, also can intercept simultaneously and contain the harmful substance that produces behind the agent explosion and get into the human body, improves system security nature.
The invention has the advantages that:
the invention uses a semiconductor bridge of an energy-containing system to detonate an energy-containing medicament to generate micro-detonation, the micro-detonation generates explosion shock waves to deform an isolation layer and extrude the medicament in a medicament storage mechanism, so that the liquid medicament penetrates through the skin of a human body to enter the human body in a jet flow mode; the isolation layer has air permeability and ductility, so that not only can the explosion shock wave be transmitted, but also harmful substances generated after the energetic medicament explodes can be intercepted and enter a human body, and the system safety is improved; the invention is in an array patch type, can meet the requirements of noninvasive, rapid and efficient drug delivery for human bodies by carrying out drug delivery, has low cost and low power consumption, can be used for one time, and reduces the possibility of cross infection of infectious diseases; the isolation layer has gas permeability and ductility, not only can transmit the explosion shock wave, but also can intercept the harmful substance that contains to produce behind the agent explosion and get into the human body simultaneously, improves system security nature.
Drawings
FIG. 1 is a schematic diagram of an embodiment of a flexible micro-system for non-invasive rapid drug delivery on body surfaces based on shockwave microjets according to the present invention;
FIG. 2 is an exploded view of an embodiment of the present invention of a flexible micro-system for non-invasive rapid drug delivery on body surfaces based on shockwave microjets;
FIG. 3 is an exploded view of an energy-containing system of an embodiment of the flexible micro-system for non-invasive rapid drug delivery on body surfaces based on shockwave microjets of the present invention;
fig. 4 is a schematic diagram of a flexible substrate of an embodiment of the flexible micro-system for non-invasive rapid drug delivery on body surface based on shockwave microjet of the present invention, wherein (a) is a front view and (b) is a back view.
Detailed Description
The invention will be further elucidated by means of specific embodiments in the following with reference to the drawing.
As shown in fig. 1 and 2, the flexible micro-system for noninvasive and rapid drug delivery based on shockwave microjet of the present embodiment comprises: the device comprises a flexible substrate 1, a medicine storage mechanism mounting groove array, a nozzle hole, a medicine storage mechanism array, an isolation layer 3, a flexible circuit board 7, an energy-containing system array, a connecting electrode array and a power supply; wherein, the flexible substrate 1 is made of flexible material; the front surface of the flexible substrate 1 is provided with a plurality of medicine storage mechanism mounting grooves 11, the medicine storage mechanism mounting grooves 11 are arranged in a two-dimensional array to form a medicine storage mechanism mounting groove array, and the bottom surface of each medicine storage mechanism mounting groove is provided with a nozzle hole 12 which is communicated with the back surface of the flexible substrate, as shown in fig. 4; the medicine storage mechanism 2 is arranged in each medicine storage mechanism mounting groove, so that the plurality of medicine storage mechanisms 2 are arranged in a two-dimensional array to form a medicine storage mechanism array, medicines are contained in each medicine storage mechanism 2, and each medicine storage mechanism 2 comprises a medicine storage bin 21 and a nozzle 22; arranging an isolation layer 3 on the medicine storage mechanism array, wherein the isolation layer 3 is made of a material with ductility and air permeability; a plurality of energy-containing systems 5 are welded on the lower surface of the flexible circuit board 7, each energy-containing system 5 corresponds to one drug storage mechanism, so that the energy-containing systems 5 are arranged in a two-dimensional array to form an energy-containing system array, a plurality of pairs of connecting electrodes 6 are arranged on the upper surface of the flexible circuit board 7, each pair of connecting electrodes 6 corresponds to one energy-containing system 5, so that the connecting electrodes 6 are arranged in a two-dimensional array to form a connecting electrode array, and each energy-containing system 5 is electrically connected to the corresponding connecting electrode 6; each pair of connecting electrodes 6 is connected to a power supply 9 through a power supply connecting wire 8, and the power supply 9 is provided with a switch;
as shown in fig. 3, each energetic system comprises a semiconductor bridge 51, a charge ring 52, and an energetic agent 53; the semiconductor bridge comprises a semiconductor bridge wire 511 and semiconductor bridge electrodes at two ends of the semiconductor bridge wire 512; a pair of semiconductor bridge electrodes of each semiconductor bridge is soldered to the lower surface of the flexible circuit board 7 and electrically connected to a corresponding pair of connection electrodes; each semiconductor bridge corresponds to one medicine storage mechanism, so that a plurality of semiconductor bridges are welded on the lower surface of the flexible circuit board 7 and arranged in a two-dimensional array to form a semiconductor bridge array; arranging a drug column ring below the semiconductor bridge; the drug column ring is a circular flat plate with a through hole in the center; energy-containing medicaments are placed in the through holes of the medicament column rings and are positioned right below the semiconductor bridge wire, so that each energy-containing medicament is aligned with the corresponding medicament storage mechanism;
in the embodiment, the flexible substrate is made of flexible rubber and has a thickness of 7 mm; the material of the drug column ring adopts resin, and the height is 0.8 mm; 0.4mg of copper azide is adopted as an energetic medicament; the isolation layer is a PDMS film with the thickness of 1 mm; the medicine storage mechanism comprises a medicine storage bin 21 and a nozzle 22; the medicine storage bin is a columnar shell with openings at the top end and the bottom end, nozzles communicated into a whole are arranged at the bottom of the medicine storage bin to form a funnel shape, and the bottom of each nozzle of each medicine storage mechanism is over against a nozzle hole at the bottom surface of the medicine storage mechanism mounting groove; the length of the nozzle is 2 mm; the flexible circuit board adopts a polyimide film; the semiconductor bridge wire of the semiconductor bridge is made of arsenic-doped silicon with a doping concentration of 1 × 10 20 Ion/cm 3 (ii) a The length of the semiconductor bridge is 1.7mm, the width is 0.4mm, and the thickness is 4 μm; the source adopts a lithium ion battery, and the power supply voltage is 5V.
The implementation method of the flexible micro-system based on the shock wave microjet noninvasive rapid drug delivery of the embodiment comprises the following steps:
1) system connections are shown in fig. 1 to 4;
2) the back surface of a flexible substrate of a flexible micro-system for noninvasive and rapid drug delivery based on shock wave microjet is arranged on the surface of human skin, and nozzle holes at the bottom of a drug storage mechanism mounting groove array are tightly attached to the surface of the human skin;
3) turning on a self-contained switch of a power supply, switching on the power supply, and applying voltage to a semiconductor bridge of the energy-containing system by the power supply through a connecting electrode;
4) the semiconductor bridge wire is rapidly heated and gasified to generate an electric explosion effect, the energetic medicament in the explosive column ring is detonated slightly, and the explosive shock wave is generated by the slight detonation;
5) under the action of the explosive shock wave, the isolation layer deforms and extrudes the medicine in the medicine storage mechanism, so that the liquid medicine is ejected from a nozzle of the medicine storage mechanism in a jet mode, reaches the skin of a human body through a nozzle hole at the bottom of the medicine storage mechanism mounting groove and permeates the skin of the human body to enter the human body;
6) the isolation layer has gas permeability and ductility, not only can transmit the explosion shock wave, also can intercept simultaneously and contain the harmful substance that produces behind the agent explosion and get into the human body, improves system security nature.
It is finally noted that the disclosed embodiments are intended to aid in the further understanding of the invention, but that those skilled in the art will appreciate that: various substitutions and modifications are possible without departing from the spirit and scope of the invention and the appended claims. Therefore, the invention should not be limited to the embodiments disclosed, but the scope of the invention is defined by the appended claims.
Claims (9)
1. A flexible micro-system for noninvasive rapid drug delivery based on shock wave microjet, which is characterized by comprising: the device comprises a flexible substrate, a medicine storage mechanism mounting groove array, a nozzle hole, a medicine storage mechanism array, an isolation layer, a flexible circuit board, an energy-containing system array, a connecting electrode array and a power supply; the flexible substrate is made of flexible materials; the front surface of the flexible substrate is provided with a plurality of medicine storage mechanism mounting grooves which are arranged in a two-dimensional array to form a medicine storage mechanism mounting groove array, and the bottom surface of each medicine storage mechanism mounting groove is provided with a nozzle hole which is communicated with the back surface of the flexible substrate; a medicine storage mechanism is arranged in each medicine storage mechanism mounting groove, so that a plurality of medicine storage mechanisms are arranged in a two-dimensional array to form a medicine storage mechanism array, and medicines are contained in each medicine storage mechanism; arranging an isolation layer on the medicine storage mechanism array, wherein the isolation layer is made of a material with ductility and air permeability; a plurality of energy-containing systems are welded on the lower surface of the flexible circuit board, each energy-containing system corresponds to one medicine storage mechanism, and therefore the energy-containing systems are arranged in a two-dimensional array to form an energy-containing system array; arranging a plurality of pairs of connecting electrodes on the upper surface of the flexible circuit board, wherein each pair of connecting electrodes corresponds to one energy-containing system, so that the plurality of pairs of connecting electrodes are arranged in a two-dimensional array to form a connecting electrode array, and each energy-containing system is electrically connected to the corresponding connecting electrode;
each pair of connection electrodes is connected to a power supply;
each energetic system comprises a semiconductor bridge, a drug pillar ring and an energetic agent; the semiconductor bridge comprises a semiconductor bridge wire and semiconductor bridge electrodes at two ends of the semiconductor bridge wire; the pair of semiconductor bridge electrodes of each semiconductor bridge are welded on the lower surface of the flexible circuit board and are electrically connected to the corresponding pair of connecting electrodes; each semiconductor bridge corresponds to one medicine storage mechanism, so that a plurality of semiconductor bridges are welded on the lower surface of the flexible circuit board and arranged in a two-dimensional array to form a semiconductor bridge array; arranging a drug column ring below the semiconductor bridge; the drug column ring is a circular flat plate with a through hole in the center; energy-containing medicaments are placed in the through holes of the medicament column rings and are positioned right below the semiconductor bridge wire, so that each energy-containing medicament is aligned with the corresponding medicament storage mechanism;
the back of a flexible substrate of the flexible micro-system for noninvasive and rapid drug delivery based on shock wave microjet is arranged on the surface of human skin, and nozzle holes at the bottom of a drug storage mechanism mounting groove array are tightly attached to the surface of the human skin; switching on a power supply, wherein the power supply applies voltage to a semiconductor bridge of the energy-containing system through a connecting electrode; the semiconductor bridge wire is rapidly heated and gasified to generate an electric explosion effect, the energetic medicament in the explosive column ring is subjected to micro-detonation, and the micro-detonation generates an explosion shock wave; under the action of the explosive shock wave, the isolation layer deforms and extrudes the medicine in the medicine storage mechanism, so that the liquid medicine is ejected from the medicine storage mechanism in a jet flow mode, reaches the skin of a human body through a nozzle hole at the bottom of the medicine storage mechanism mounting groove and permeates the skin of the human body to enter the human body; the isolation layer has gas permeability and ductility, not only can transmit the explosion shock wave, also can intercept simultaneously and contain the harmful substance that produces behind the agent explosion and get into the human body, improves system security nature.
2. The flexible micro-system for noninvasive and rapid drug delivery based on shockwave micro-jet according to claim 1, wherein the flexible material of the flexible substrate is rubber, soft silica gel or flexible resin, and the thickness is 6.5-7.5 mm.
3. The flexible micro-system for noninvasive and rapid drug delivery based on shockwave micro-jet according to claim 1, wherein the material of said drug post ring is resin or hard rubber, and the height is 0.7-0.9 mm.
4. The flexible micro-system for noninvasive rapid drug delivery based on shockwave micro-fluidics according to claim 1, wherein said energetic pharmaceutical agent is copper azide or silver azide.
5. The flexible micro-system for noninvasive and rapid drug delivery based on shockwave micro-jet according to claim 1, wherein the isolation layer is made of PDMS film with a thickness of 0.9-1.1 mm.
6. The flexible non-invasive rapid drug delivery system based on shockwave microjet according to claim 1, wherein said drug storage mechanism comprises a drug cartridge and a nozzle; the medicine storage bin is a columnar shell with openings at the top end and the bottom end, nozzles communicated into a whole are arranged at the bottom of the medicine storage bin to form a funnel shape, and the bottom of each nozzle of each medicine storage mechanism is over against a nozzle hole at the bottom surface of the medicine storage mechanism mounting groove; the length of the nozzle is 1.8-2.2 mm.
7. The flexible noninvasive rapid drug delivery microsystem based on shockwave microjet according to claim 1, wherein the semiconductor bridge wire of said semiconductor bridge is silicon doped with non-metallic material; doping with one or more of arsenic, phosphorus and boron at a concentration of 5 × 10 18 ～3×10 20 Ion/cm 3 。
8. The flexible micro-system for noninvasive rapid drug delivery based on shockwave micro-fluidics according to claim 1, wherein said semiconductor bridge has a length of 1.5mm to 2mm, a width of 0.3mm to 0.5mm and a thickness of 2 μm to 5 μm.
9. The flexible micro-system for noninvasive and rapid drug delivery based on shockwave micro-jet according to claim 1, wherein the power supply is a lithium ion battery with a supply voltage of 4.5-5.5V.
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| CN108968924A (en) * | 2018-05-28 | 2018-12-11 | 重庆大学 | A kind of bleeding medicine releasing capsule |
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| WO2021210901A1 (en) * | 2020-04-14 | 2021-10-21 | 주식회사 제이시스메디칼 | Drug injection device using pulse shock wave |
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| US6966990B2 (en) * | 2002-10-11 | 2005-11-22 | Ferro Corporation | Composite particles and method for preparing |
| IL213766A (en) * | 2011-06-23 | 2016-03-31 | Rafael Advanced Defense Sys | Energetic unit based on semiconductor bridge |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4564363A (en) * | 1983-07-13 | 1986-01-14 | Smithkline Beckman Corporation | Delayed action assembly |
| CN100998905A (en) * | 2006-12-26 | 2007-07-18 | 重庆大学 | Medicine reliesing micro electronic capsule |
| CN108968924A (en) * | 2018-05-28 | 2018-12-11 | 重庆大学 | A kind of bleeding medicine releasing capsule |
| WO2021210901A1 (en) * | 2020-04-14 | 2021-10-21 | 주식회사 제이시스메디칼 | Drug injection device using pulse shock wave |
| CN112254586A (en) * | 2020-09-03 | 2021-01-22 | 北京大学 | Composite energetic film semiconductor bridge |
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