CN114288216A - Antioxidant and anti-saccharification composition and preparation method thereof - Google Patents
Antioxidant and anti-saccharification composition and preparation method thereof Download PDFInfo
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Abstract
The invention provides an antioxidant and anti-saccharification composition and a preparation method thereof, belonging to the field of skin care products. The antioxidant anti-saccharification composition comprises the following components: hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, a European cherry blossom extract, a red sage root extract, a dispersant, a stabilizer and water. The antioxidant and anti-saccharification composition disclosed by the invention has synergistic effect and has the effects of resisting oxidation and saccharification. The composition also has the advantages of effectively locking water, promoting the synthesis of collagen and increasing the skin elasticity. The active ingredients of the composition can be more stable by compounding with the polyhydric alcohol, the use convenience of the active ingredients is improved, and the skin irritation is reduced.
Description
Technical Field
The invention belongs to the field of skin care products, and relates to an antioxidant and anti-saccharification composition and a preparation method thereof.
Background
Advanced glycation end products (AGEs) refer to adducts formed between carbonyl groups on reducing sugars (e.g., glucose) and free amino groups on macromolecules such as proteins, lipids, or nucleic acids. Food intake and the body's own glycation reactions lead to the formation of advanced glycation end products by the body. AGEs can form pigment adducts with proteins, leading to skin pigmentation and dull skin tone. In addition, AGEs can form crosslinks with collagen and elastin, affecting their normal function, causing a decrease in skin elasticity, ultimately leading to skin aging. The current solutions of cosmetics on the market for whitening are mainly made for melanin, but for the problem of dark yellow skin caused by advanced glycosylation end products, the solution for melanin does not solve the problem well. For solving the problem of dark yellow skin, the current solution is limited to the reaction of anti-glycation agents instead of proteins with sugar, and the anti-glycation agents are combined with glycosylated proteins competitively to block the glycosylation reaction, so that the generation of AGEs is avoided. The existing method has too single effective channel and limited anti-saccharification effect.
In addition, due to the influence of ultraviolet rays, haze, automobile exhaust, working pressure, work and rest habits and the like, a human body can easily generate free radicals, and the free radicals can damage cells, so that skin aging is caused. However, most of the existing cosmetics on the market declare antioxidant are oil-soluble antioxidant ingredients, and cannot be added into aqueous products, so that the practicability of the raw materials is greatly reduced.
Based on the condition that the product on the market only has single anti-oxidation or anti-saccharification effect and obviously cannot meet the market requirement, the development of a safe and effective product with anti-oxidation and anti-saccharification effects is necessary.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide an antioxidant and anti-saccharification composition and a preparation method thereof. The invention has the advantages of oxidation resistance, saccharification resistance, water locking, collagen synthesis promotion, skin elasticity increase and stable active ingredients.
In order to achieve the purpose, the invention adopts the technical scheme that:
an antioxidant and anti-saccharification composition comprises the following components: hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, a European cherry blossom extract, a red sage root extract, a polyhydric alcohol, a stabilizer and water.
The applicant combines theory and practice, and a large number of experiments show that the antioxidant and anti-saccharification active substance compound has outstanding effects and obvious synergistic effect on antioxidation and anti-saccharification by compounding the active substances such as hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, a prunus cerasifera extract, a salvia miltiorrhiza extract and the like.
The hydrolyzed hyaluronic acid with ultrahigh biological activity and extremely low molecular weight (less than or equal to 5K Da) obtained by adopting the enzyme cutting process and the spray drying process of the patent can quickly penetrate through epidermis to reach a dermis layer, remove free radicals, reduce the activity of inflammatory factors, inhibit inflammatory reaction, repair damaged cells and resist skin inflammation and sensitivity caused by various stimuli; ROS can be eliminated through self degradation, and the antioxidation effect can be exerted through improving the activity of antioxidant enzyme in vivo, so that the generation of inflammatory reaction is avoided; natural intelligent moisturizing factor, 1 molecule of HA can lock 1000 times of water.
The magnesium ascorbyl phosphate has excellent effect of eliminating free radicals in cells and can promote the synthesis of collagen.
Fullerene can be used as a catalyst to convert superoxide anions into oxygen molecules or combine with free radicals, can effectively remove free radicals in cells, has the oxidation resistance 250 times that of VC, and can still stably exert the super-strong oxidation resistance under the irradiation of ultraviolet rays.
The decarboxylated carnosine hydrochloride can effectively remove free radicals, active sugar compounds, prevent sugar oxidation vicious cycle, prevent AGEs from generating, efficiently resist saccharification, remove lipid peroxide-LOOH, block oxidation chain reaction, protect DNA from inhibiting color deposition and promote collagen generation.
The extract of Prunus CERASUS (PRUNUS CERASUS) flower is extracted by Eutectys patent technology, and has high moisture keeping effect, provides comprehensive photoaging protection, reduces DNA damage caused by blue light radiation, and has high saccharification resisting effect.
Salvia MILTIORRHIZA (Salvia Miltiorrhiza) extract has effects of eliminating reducing sugar, eliminating glycated protein, breaking formed cross-link, reversing glycation, and strongly resisting sugar.
As a preferred embodiment of the composition, the antioxidant and anti-saccharification composition comprises the following components in percentage by weight: 0.02-0.5% of hydrolyzed sodium hyaluronate, 0.1-3.0% of magnesium ascorbyl phosphate, 0.01-0.1% of fullerene, 0.05-0.2% of decarboxypeptide hydrochloride, 0.2-3.0% of cherry European acid flower extract, 0.1-5.0% of salvia miltiorrhiza extract, 60-80% of polyhydric alcohol, 0.1-1% of stabilizer and the balance of water.
As a preferred embodiment of the composition, the antioxidant and anti-saccharification composition comprises the following components in percentage by weight: 0.05-0.25% of hydrolyzed sodium hyaluronate, 0.5-2.0% of magnesium ascorbyl phosphate, 0.02-0.07% of fullerene, 0.08-0.15% of decarboxypeptide hydrochloride, 0.5-1.0% of cherry European acid flower extract, 0.2-2% of salvia miltiorrhiza extract, 65-75% of polyhydric alcohol, 0.3-0.8% of stabilizer and the balance of water. The composition formed within this range exhibits better anti-glycation, anti-oxidation, moisturizing and skin elasticity increasing effects.
As a preferred embodiment of the composition, the antioxidant and anti-saccharification composition comprises the following components in percentage by weight: 0.1% of hydrolyzed sodium hyaluronate, 2.0% of magnesium ascorbyl phosphate, 0.05% of fullerene, 0.1% of decarboxylated carnosine hydrochloride, 0.8% of a cherry blossom extract, 0.5% of a salvia miltiorrhiza extract, 75% of butanediol, 0.5% of sodium citrate and the balance of water.
In a preferred embodiment of the composition of the present invention, the mass ratio of the hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate and fullerene is: magnesium ascorbyl phosphate: fullerene is 1:20: 0.5.
The inventor finds that the hydrolysis of sodium hyaluronate: magnesium ascorbyl phosphate: when fullerene is 1:20:0.5, the antioxidant and anti-glycation composition shows optimal DPPH clearance rate, and shows obvious synergistic effect compared with the composition without one component and the composition with other proportion.
As a preferred embodiment of the composition of the present invention, the mass ratio of the decarboxylated carnosine hydrochloride, the prunus cerasifera extract and the salvia miltiorrhiza extract is as follows: extract of prunus cerasifera: the salvia miltiorrhiza extract is 1:8: 5.
The inventor finds that the decarboxylated carnosine hydrochloride: extract of prunus cerasifera: when the salvia miltiorrhiza extract is 1:8:5, the antioxidant and anti-saccharification composition shows the optimal skin dark yellow improvement effect, and shows obvious synergistic effect compared with the composition without a certain component and the compositions with other proportions.
As a preferred embodiment of the composition of the present invention, the polyhydric alcohol is any one of propylene glycol, glycerin, dipropylene glycol, and butylene glycol.
As a preferred embodiment of the composition of the present invention, the polyol is butanediol.
The inventor finds that the butanediol is selected to be compounded with the composition, so that the active ingredients are more stable, the use convenience of the active ingredients is improved, and the skin irritation is reduced. The butanediol plays a role of a solvent and also has a certain antiseptic effect, so the composition does not need to be added with an antiseptic.
As a preferred embodiment of the composition of the present invention, the stabilizer is sodium citrate.
The invention also provides a preparation method of the antioxidant and anti-saccharification composition, which comprises the following steps: (1) weighing the components in percentage by weight; (2) dissolving magnesium ascorbyl phosphate in water at 60-70 ℃ to obtain a solution A; (3) dissolving hydrolyzed sodium hyaluronate and butanediol in 82-85 deg.C water; (4) cooling the mixture obtained in the step (3) to 50 ℃, and adding sodium citrate to dissolve the mixture evenly; (5) cooling the mixture in the step (4) to 45 ℃, adding fullerene, decarboxylated carnosine hydrochloride, a European cherry blossom extract and a salvia miltiorrhiza extract, and dissolving uniformly; (6) and (4) cooling the mixture obtained in the step (5) to 40 ℃, adding the solution A, and uniformly mixing to obtain the antioxidant and anti-saccharification composition.
The inventor finds that magnesium ascorbyl phosphate is dissolved in the step (2) in advance and then mixed with other materials in the step (6) to ensure the stability of the composition, otherwise, solid is separated out in the later period.
The antioxidant and anti-saccharification composition is suitable for application in preparation of skin care products.
Compared with the prior art, the invention has the following beneficial effects:
(1) the multifunctional composite antioxidant is compounded by various active ingredients including hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, a European cherry blossom extract and a red sage root extract, has a synergistic effect, resists external stimulation, avoids generating free radicals, and can eliminate the free radicals generated in vivo to achieve a high-efficiency antioxidant effect.
(2) The invention has synergistic effect of various active components, can replace the reaction of protein and sugar, can remove reducing sugar, reverse the saccharified protein, resist saccharification in multiple paths and resist saccharification in high efficiency.
(3) The composition of the invention can effectively lock water, promote the synthesis of collagen and increase the skin elasticity.
(4) According to the invention, through screening proper polyhydric alcohols for compounding, the active ingredients are more stable, the convenience of use of the active ingredients is increased, and skin irritation is reduced.
(5) The invention obtains the best antioxidant and anti-saccharification effect through reasonable collocation, and has the effects of moisturizing and increasing skin elasticity.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples. In the examples, unless otherwise specified, the experimental methods are all conventional methods; unless otherwise indicated, all reagents and materials are commercially available.
Examples 1 to 5
Examples 1-5 are all examples of antioxidant anti-glycation compositions of the present invention. The antioxidant and anti-glycation compositions of examples 1-5 were prepared by combining hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, acerola prunus cerasifera extract, salvia miltiorrhiza extract, butylene glycol, sodium citrate and water, and the ratio of each component is shown in table 1.
TABLE 1 weight percent composition/% of the antioxidant anti-glycation compositions of examples 1-5
Comparative examples 1 to 6
Comparative examples 1-6 are comparative examples in which the antioxidant and anti-glycation composition of the present invention lacks a certain component. The compounding ratio of each component of comparative examples 1 to 6 is shown in Table 2.
TABLE 2 weight percent composition/% of the compositions of comparative examples 1-6
Comparative example 7
Comparative example 7 is a comparative example of the antioxidant and anti-glycation composition of the present invention, and the components and contents are the same except that the butylene glycol is replaced with propylene glycol of the same added content as in example 2.
Comparative example 8
Comparative example 8 is a comparative example of the antioxidant and anti-glycation composition of the present invention, and the components and contents are the same except that glycerin having the same added content is substituted for butylene glycol, which is different from example 3.
Comparative example 9
Comparative example 9 is a comparative example of the antioxidant and anti-glycation composition of the present invention, and the components and contents are the same except that the butanediol is replaced with dipropylene glycol of the same added content as in example 4.
To illustrate the beneficial effects of the antioxidant and anti-glycation compositions and skin care products of the present invention, the following tests were performed:
(1) oxidation resistance test
DPPH free radical clearance determination experiment test method: 2mL of each of the antioxidant and antiglycation compositions prepared in examples 1 to 5 and comparative examples 1 to 6 and 8mL of each of 1X 10-4mixing the DPPH-ethanol solution of mol/L, shaking uniformly, placing in a dark place at 25 ℃ for light-shielding reaction for 30min, placing the mixed solution in a centrifuge, centrifuging at 7000rpm for 5min, taking the centrifuged supernatant, and measuring the absorbance A1 at the wavelength of 517 nm; the same operation was carried out with 2mL of absolute ethanol, and the absorbance A2 was measured; the same operation was carried out with 2mL of deionized water, and the absorbance A3 was measured; taking 2mL of vitamin C solution with the concentration of 1mg/mL as a positive control, setting 3 groups of parallel experiments for calculating an average value for each group, and calculating the free radical scavenging capacity of the antioxidant and anti-saccharification composition of different groups according to a DPPH clearance formula. DPPH clearance rate [1- (A1-A2)/A3]X 100%. The DPPH clearance test results are shown in table 3.
TABLE 3 DPPH Clearance test results for compositions of examples 1-5 and comparative examples 1-6
And (3) testing results: as can be seen from table 3, compared with comparative examples 1 to 6, the DPPH radical clearance rates of the antioxidant and anti-glycation compositions prepared in examples 1 to 5 all reached more than 54%, while the DPPH radical clearance rates of the antioxidant and anti-glycation compositions prepared in comparative examples 1 to 6 were all lower due to the lack of one of the raw material components, thereby demonstrating that the antioxidant and anti-glycation compositions prepared by using hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, prunus cerasus prunus cerasifera extract, and salvia miltiorrhiza extract in the present invention have higher DPPH radical clearance rates and good antioxidant effects; the increase in DPPH clearance is decreased for comparative examples 1-5, and the DPPH clearance is best for example 3, thus indicating that example 3 is the best combination partner.
(2) Anti-glycation assay
The test method comprises the following steps: the experiment for improving the dark yellow and improving the brightness effect is carried out, 110 female volunteers with the dark yellow faces of 30-50 years old and working in front of electronic equipment often outdoors or for a long time are selected and randomly divided into 11 groups, each group uses examples 1-5 and comparative examples 1-6 respectively for two months, the improvement condition of the dark yellow skins is observed and felt according to the use condition, and relevant questionnaires are filled in. The statistical test results are as follows:
TABLE 4 anti-glycation test results for compositions of examples 1-5
TABLE 5 anti-glycation test results for comparative examples 1-6 compositions
And (3) testing results: as can be seen from tables 4 to 5 above, the antioxidant and antiglycation compositions prepared in examples 1 to 5 were tested by volunteers to have 28 persons, 25.45% of the total number, and 3.64% of the total number, which had no improvement in the feeling of dark yellow, compared to comparative examples 1 to 6, whereas the antioxidant and antiglycation compositions prepared in comparative examples 1 to 6, which had a shortage of one of the raw material components, had only 6 persons, 5.45% of the total number, and 36.37% of the total number, which had no improvement in the feeling of dark yellow. Therefore, the antioxidant and anti-saccharification composition prepared by adopting the hydrolyzed sodium hyaluronate, the magnesium ascorbyl phosphate, the fullerene, the decarboxylated carnosine hydrochloride, the European cherry blossom extract and the salvia miltiorrhiza extract has higher effect of improving the dark yellow condition of the skin and good anti-saccharification effect; in comparative examples 1 to 5, there was a decrease in the improvement in skin, and the number of volunteers with significant sensory skin improvement and no improvement in sensory skin improvement in example 3 was zero, thus indicating that example 3 is the best combination.
(3) Moisture retention test
The percutaneous water loss test method comprises the following steps: the moisture content of the facial skin of the subject before and after the product was applied was measured by a transdermal moisture loss meter, model SWL5201, Delfin corporation, Finland, and the TEWL parameter was compared with the moisture loss of the skin of the subject before and after the product was applied. Wherein the delta TEWL is (TEWL1-TEWL2)/TEWL1 x 100 percent, TEWL1 is a test value before the product is not used, TEWL2 is a test value after the product is used, and the larger the value of the delta TEWL is, the larger the reduction amplitude of the percutaneous water loss after the product is used on the test skin is, and the better the barrier repair and moisture retention effects of the product are. The average values for each group were recorded and calculated as shown in table 6 below.
TABLE 6 results of the transdermal moisture loss test of the compositions of examples 1-5 and comparative examples 1-6
| Test sample | TEWL1 | TEWL2 | △TEWL(％) |
| Example 1 | 19.52 | 11.36 | 41.8 |
| Example 2 | 21.33 | 13.05 | 38.81 |
| Example 3 | 22.35 | 12.25 | 45.19 |
| Example 4 | 19.04 | 11.56 | 39.29 |
| Example 5 | 20.26 | 12.65 | 37.56 |
| Comparative example 1 | 18.52 | 16.23 | 12.37 |
| Comparative example 2 | 17.85 | 15.35 | 14.01 |
| Comparative example 3 | 18.56 | 16.25 | 12.45 |
| Comparative example 4 | 19.52 | 16.56 | 15.16 |
| Comparative example 5 | 18.54 | 15.35 | 17.21 |
| Comparative example 6 | 17.56 | 15.21 | 13.38 |
And (3) testing results: as can be seen from table 6 above, the delta TEWL data of the antioxidant and anti-glycation compositions prepared in examples 1 to 5 all reached more than 37% compared to comparative examples 1 to 6, whereas the delta TEWL data of the antioxidant and anti-glycation compositions prepared in comparative examples 1 to 6 were lower due to the absence of one of the raw material components, thereby illustrating that the antioxidant and anti-glycation compositions prepared by using hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, prunus cerasus extract, and salvia miltiorrhiza extract in the present invention have significant moisturizing effect; in comparative examples 1-5, example 3 showed the highest transdermal moisture retention, thus indicating that example 3 is the best combination partner.
(4) Test for increasing skin elasticity
Test method for increasing skin elasticity: similar to the skin moisturizing condition test, the skin elasticity value R2 before and after the application of the test part was measured using a skin elasticity tester (model: MPA580, CK company, germany) before and after the application of the sample, and the degree of change in the skin elasticity was evaluated based on the difference between the values before and after the skin elasticity value, where Δ R2 is R2 (after application) -R2 (before application), and the larger the Δ R2 value is, the more the elasticity is increased. And taking the average value of each group of test results to record.
TABLE 7 increased skin elasticity test results for compositions of examples 1-5 and comparative examples 1-6
And (3) testing results: as can be seen from table 7 above, the skin elasticity increasing values of the antioxidant and anti-glycation compositions prepared in examples 1 to 5 were all greater than 0.32, compared to comparative examples 1 to 6, whereas the skin elasticity increasing values of the antioxidant and anti-glycation compositions prepared in comparative examples 1 to 6 were lower due to the absence of one of the raw material components, thus demonstrating that the antioxidant and anti-glycation compositions prepared by using hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, prunus cerasus extract, and salvia miltiorrhiza extract in the present invention have excellent skin elasticity increasing function; comparing examples 1-5, example 3 showed the greatest increase in skin elasticity, thus indicating that example 3 is the best combination partner.
(5) Safety test
The spot-pasting experiment testing method comprises the following steps: the antioxidant and anti-glycation compositions prepared in all the above examples and a control group (deionized water) were subjected to a human safety patch test according to the human skin patch test in 2015 cosmetic safety specifications. The method for the skin closed patch test comprises the following steps: selecting 30 persons with age of 18-60 years, selecting the persons with area not more than 50mm2And a qualified plaque test device having a depth of about 1mm, 0.020mL of the restorative and compact composition prepared in the above examples and comparative examples was placed in the plaque test device chamber, the control well was blank (no material placed),the patch test device added with the repairing and tightening composition is applied to the curved side of the forearm of a subject by using hypoallergenic adhesive tape, and is lightly pressed by hands to be uniformly applied to the skin for 24 hours. Skin reactions were observed according to the standard of table 4 30min (after disappearance of the indentation), 24h and 48h after removal of the plaque tester containing the restorative and tightening composition, respectively, and the observations were recorded. Skin occlusion patch test skin response grading criteria are shown in table 8 below.
TABLE 8 grading Standard of skin reaction in skin-closed Patch experiment
TABLE 9 test results of Patch test for compositions of examples 1-5
| Sample numbering | 30min | 24h | 48h | Total result |
| Example 1 | 0 | 0 | 0 | No positive reaction for 30 people |
| Example 2 | 0 | 0 | 0 | No positive reaction for 30 people |
| Example 3 | 0 | 0 | 0 | No positive reaction for 30 people |
| Example 4 | 0 | 0 | 0 | No positive reaction for 30 people |
| Example 5 | 0 | 0 | 0 | No positive reaction for 30 people |
| Control group | 0 | 0 | 0 | No positive reaction for 30 people |
The test results show that the patch test results of the antioxidant and anti-saccharification composition prepared in examples 1-5 and the control group (deionized water) are negative, and that the antioxidant and anti-saccharification composition prepared by adopting hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, a prunus cerasifera extract and a salvia miltiorrhiza extract is mild and non-irritant.
(6) Raw material stability test
The test method comprises the following steps: (1) the pH of the product obtained in examples and comparative examples was measured at room temperature after dilution by mixing with water at a volume ratio of 1: 10. (2) The products obtained in the examples and the comparative examples are subjected to heat resistance, cold resistance and cold-heat cycle tests under the following test conditions: (a) respectively preserving the heat at 48 +/-2 ℃ for 3 months, and performing physical and chemical tests after the room temperature is recovered; (b) respectively preserving heat at-18 +/-2 ℃ for 3 months, and performing physicochemical test after the room temperature is recovered; (c) and (3) respectively preserving heat for 24 hours at 48 ℃, normal temperature and-18 ℃, circulating for three times according to the sequence, and carrying out physicochemical test after the room temperature to be recovered, wherein the test method is QB/T2660. The results of the tests are shown in the following table.
TABLE 10 raw material stability test results for compositions of examples 2-4 and examples 7-9
The test results show that compared with comparative examples 7-9, the examples 2-4 have no phenomena of color change, turbidity precipitation and the like under different temperature environments, and have higher stability under a system without adding a preservative; in contrast, the products obtained in comparative examples 7 to 9 exhibited darkening or bleeding or reduction in transparency in different environmental tests, and were not sufficiently stable.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. An antioxidant and anti-glycation composition, which is characterized by comprising the following components: hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate, fullerene, decarboxylated carnosine hydrochloride, a European cherry blossom extract, a red sage root extract, a polyhydric alcohol, a stabilizer and water.
2. The antioxidant and anti-glycation composition according to claim 1, characterized in that the composition comprises the following components in percentage by weight: 0.02-0.5% of hydrolyzed sodium hyaluronate, 0.1-3.0% of magnesium ascorbyl phosphate, 0.01-0.1% of fullerene, 0.05-0.2% of decarboxypeptide hydrochloride, 0.2-3.0% of cherry European acid flower extract, 0.1-5.0% of salvia miltiorrhiza extract, 60-80% of polyhydric alcohol, 0.1-1% of stabilizer and the balance of water.
3. The antioxidant and anti-glycation composition according to claim 2, characterized in that the composition comprises the following components in percentage by weight: 0.05-0.25% of hydrolyzed sodium hyaluronate, 0.5-2.0% of magnesium ascorbyl phosphate, 0.02-0.07% of fullerene, 0.08-0.15% of decarboxypeptide hydrochloride, 0.5-1.0% of cherry European acid flower extract, 0.2-2% of salvia miltiorrhiza extract, 65-75% of polyhydric alcohol, 0.3-0.8% of stabilizer and the balance of water.
4. The antioxidant and anti-glycation composition according to any one of claims 1-3, wherein the mass ratio of the hydrolyzed sodium hyaluronate, magnesium ascorbyl phosphate and fullerene is as follows: magnesium ascorbyl phosphate: fullerene is 1:20: 0.5.
5. The antioxidant and anti-glycation composition as claimed in any one of claims 1-3, wherein the mass ratio of the decarboxylated carnosine hydrochloride, the cherry European sour flower extract and the red sage root extract is, the decarboxylated carnosine hydrochloride: extract of prunus cerasifera: the salvia miltiorrhiza extract is 1:8: 5.
6. The antioxidant and antiglycation composition of any one of claims 1-3, wherein the polyol includes any one of propylene glycol, glycerin, dipropylene glycol, and butylene glycol.
7. The antioxidant anti-glycation composition of claim 6, wherein the polyol is butylene glycol.
8. The antioxidant anti-glycation composition according to any one of claims 1-3, characterized in that the stabilizer is sodium citrate.
9. The method for preparing the antioxidant and antiglycation composition as set forth in any one of claims 1 to 8, comprising the steps of: (1) weighing the components in percentage by weight; (2) dissolving magnesium ascorbyl phosphate in water at 60-70 ℃ to obtain a solution A; (3) dissolving hydrolyzed sodium hyaluronate and butanediol in 82-85 deg.C water; (4) cooling the mixture obtained in the step (3) to 50 ℃, and adding sodium citrate to dissolve the mixture evenly; (5) cooling the mixture in the step (4) to 45 ℃, adding fullerene, decarboxylated carnosine hydrochloride, a European cherry blossom extract and a salvia miltiorrhiza extract, and dissolving uniformly; (6) and (4) cooling the mixture obtained in the step (5) to 40 ℃, adding the solution A, and uniformly mixing to obtain the antioxidant and anti-saccharification composition.
10. Use of the antioxidant anti-glycation composition according to any one of claims 1-8 in skin care products.
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| CN114848532A (en) * | 2022-05-24 | 2022-08-05 | 珀莱雅化妆品股份有限公司 | A composition rich in biotin and guanosine for cosmetics and its preparation method |
| CN114903810A (en) * | 2022-05-31 | 2022-08-16 | 科瑞高(青岛)医药科技有限公司 | Anti-wrinkle composition containing peptide and application thereof |
| CN117180122A (en) * | 2023-11-02 | 2023-12-08 | 杭州湃肽生化科技有限公司 | Composition for relaxing and repairing allergy and application thereof |
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