CN114280815A - Intelligent contact lens containing flexible circuit and preparation method thereof - Google Patents
Intelligent contact lens containing flexible circuit and preparation method thereof Download PDFInfo
- Publication number
- CN114280815A CN114280815A CN202210013801.6A CN202210013801A CN114280815A CN 114280815 A CN114280815 A CN 114280815A CN 202210013801 A CN202210013801 A CN 202210013801A CN 114280815 A CN114280815 A CN 114280815A
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- Prior art keywords
- contact lens
- flexible circuit
- layer
- packaging
- packaging layer
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- 238000002360 preparation method Methods 0.000 title abstract description 13
- 238000004806 packaging method and process Methods 0.000 claims abstract description 49
- 239000000463 material Substances 0.000 claims abstract description 29
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 239000000853 adhesive Substances 0.000 claims description 14
- 230000001070 adhesive effect Effects 0.000 claims description 14
- 239000000084 colloidal system Substances 0.000 claims description 13
- 238000010438 heat treatment Methods 0.000 claims description 13
- 239000005022 packaging material Substances 0.000 claims description 12
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 7
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 7
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 7
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 7
- 229910052709 silver Inorganic materials 0.000 claims description 7
- 239000004332 silver Substances 0.000 claims description 7
- 229910000831 Steel Inorganic materials 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 6
- 239000010959 steel Substances 0.000 claims description 6
- 229920005839 ecoflex® Polymers 0.000 claims description 5
- 229920001971 elastomer Polymers 0.000 claims description 5
- 239000000806 elastomer Substances 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 210000003128 head Anatomy 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims description 3
- 238000005245 sintering Methods 0.000 claims description 3
- 238000010023 transfer printing Methods 0.000 claims description 3
- 239000008393 encapsulating agent Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 abstract description 7
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 238000005538 encapsulation Methods 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229910021389 graphene Inorganic materials 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 238000012858 packaging process Methods 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Images
Abstract
The invention discloses an intelligent contact lens containing a flexible circuit and a preparation method thereof. The invention does not introduce additional substrate materials, and the materials adopted by the packaging layer have higher stretchability and bendability, and the whole preparation process can be better integrated into the current production flow of the contact lenses, thereby having the potential of large-scale production.
Description
Technical Field
The invention relates to the technical field of contact lenses, in particular to an intelligent contact lens containing a flexible circuit and a preparation method thereof.
Background
As a special human-computer interface, the intelligent contact lens is a device platform closest to human eyes. By using advanced technologies such as functional materials, micro-nano electronics and the like, the intelligent contact lenses can detect and track physiological information of eyes, such as intraocular pressure, ocular surface heat, electrolyte content and the like, so that diagnosis basis and treatment assistance are provided for clinical medical treatment; in addition, smart contact lenses also have the potential to become a new generation of human-computer interaction platform, and realize a series of visual experience enhancement functions including augmented reality, virtual reality, smart office and the like.
However, in order to achieve the rich and complex functions, it is necessary to integrate functional circuits into the contact lens. While the use of flexible circuits has facilitated the implementation of smart contact lenses, there is a lack of a more rational way to produce them. At present, the flexible circuit implantation method of the intelligent contact lens in the field is generally as follows: preparing a functional circuit on a transparent substrate, placing the functional circuit in a mould, pouring a contact lens material, and heating and curing. However, such processes have major disadvantages: firstly, the mechanical modulus of the newly introduced substrate is not matched with that of the contact lens, so that the stability and wearing comfort of the lens are greatly influenced; secondly, the process that the circuit turns from a plane to a spherical surface exists in the production process of the contact lens, the position and the shape are difficult to determine, and the problem of misalignment is easy to occur, so that the realization of functions is influenced, and the consistency of devices is poor; thirdly, the whole preparation process is mutually split, higher requirements are put forward on the production capacity of related manufacturers, and the industrialization potential is low.
In addition to the problems inherent in the process, functional circuits require a dry operating environment and contact lenses require sufficient moisture content, so that there is a core conflict between moisture content and dry operating environment between contact lenses and functional circuits. Therefore, there is a need to develop a process for manufacturing intelligent contact lenses with flexible circuits, which ensures the isolation of the flexible circuits from water, ensures the wearing comfort of the contact lenses as much as possible on the premise of realizing the circuit functions, and has an industrial prospect of large-scale continuous production.
Disclosure of Invention
The invention provides an intelligent contact lens containing a flexible circuit and a preparation method thereof, so that the contact lens does not introduce a flexible circuit substrate material, the flexible circuit is directly packaged by adopting the existing contact lens material, and the packaging process can be directly integrated into the production flow of the existing contact lens.
The invention relates to an intelligent contact lens containing a flexible circuit, which comprises a first packaging layer, the flexible circuit, a second packaging layer and a contact lens layer which are sequentially arranged, wherein the second packaging layer is positioned on one side of the contact lens layer, which is opposite to eyes.
Furthermore, the materials adopted by the first packaging layer and the second packaging layer are the same and are both elastomer materials. Used for packaging flexible circuit and resisting water. The first packaging layer and the second packaging layer are made of PDMS, Ecoflex or silica gel.
The invention discloses a preparation method of an intelligent contact lens containing a flexible circuit, which comprises the following steps:
pouring a colloid-shaped packaging material into the outer mold of the contact lens, uniformly hanging the colloid on the wall of the outer mold of the contact lens through swinging and inclined flow control, and heating and curing the packaging material to form a first packaging layer;
step 2, preparing a flexible circuit;
coating a conductive adhesive on a steel die with a flexible circuit reverse die to fully fill the conductive adhesive into the steel die pattern to form a flexible circuit pattern, transferring the flexible circuit pattern to a first packaging layer by using a transfer printing adhesive head, and heating and sintering to form a flexible circuit; the conductive adhesive is silver conductive adhesive, specifically silver adhesive
Step 3, preparing a second packaging layer
Pouring a colloidal packaging material into a contact lens outer mold bearing the first packaging layer and the flexible circuit, uniformly hanging the packaging colloid on the surfaces of the first packaging layer and the flexible circuit through swinging and inclined flow control, and heating and curing the packaging material to form a second packaging layer;
And pouring a contact lens material into a contact lens outer mold bearing the first packaging layer, the flexible circuit and the second packaging layer, pressing the contact lens inner mold into the contact lens outer mold, fixing the contact lens inner mold and the contact lens outer mold, and heating and curing the contact lens material to form the contact lens layer.
Has the advantages that:
1) the flexible circuit does not introduce additional substrate materials, the problem that the substrate materials are not matched with the contact lens body is avoided as far as possible, and the material adopted by the packaging layer has higher stretchability and bendability. The preparation scheme provided by the invention reduces the thickness of the packaging layer to the maximum extent, improves the stretchability and simultaneously meets the requirement of the thickness of the commercial contact lens
2) The flexible circuit is transferred to the contact lens outer mold in a colloidal state and is directly molded on the curved surface of the contact lens, so that the problem of plane deformation of a substrate material does not exist, and the stable performance of the circuit is ensured.
3) The whole preparation process fully utilizes the equipment for producing the beautiful pupil by the current contact lens manufacturer, and reduces the requirement on additional equipment as much as possible.
4) The whole preparation process can be well integrated into the current production flow of the contact lenses and has the potential of large-scale production.
Drawings
Fig. 1 is a schematic view of the contact lens of the present invention.
FIG. 2 is a flow chart for the preparation of the contact lenses of the invention.
Wherein, 1, a first packaging layer; 2. a flexible circuit; 3. a second encapsulation layer; 4. a contact lens layer.
Detailed Description
As shown in fig. 1, an intelligent contact lens containing a flexible circuit comprises a first packaging layer 1, a flexible circuit 2, a second packaging layer 3 and a contact lens layer 4 which are arranged in sequence, wherein the second packaging layer 3 is positioned on the side, facing away from eyes, of the contact lens layer 4. The first encapsulating layer 1 and the second encapsulating layer 3 are made of the same material, and are made of elastomer materials such as PDMS, Ecoflex, silica gel and the like.
The encapsulation layer not only has the functions of bearing the flexible circuit 2 and ensuring the structural stability of the flexible circuit, but also provides water-proof protection for the flexible circuit 2. It will be appreciated that the configuration shown in fig. 1 is simply a schematic illustration of the contact lens configuration of the present invention, with the actual contact lens layer 4 making up the majority of the contact lens thickness and the encapsulation layer and flex circuit 2 making up only a minor portion of the contact lens, without affecting the inherent function of the contact lens.
The invention discloses a preparation method of an intelligent contact lens containing a flexible circuit, which comprises the following steps:
pouring a colloidal packaging material into the outer mold of the contact lens, uniformly hanging the colloid on the wall of the outer mold of the contact lens through swinging and inclined flow control, and heating and curing the packaging material to form a first packaging layer 1; the packaging colloid is made of elastomer materials such as polydimethylsiloxane PDMS, Ecoflex, silica gel and the like.
Step 2, preparing a flexible circuit 2;
and coating a conductive adhesive on a steel die with a flexible circuit reverse die, fully filling the conductive adhesive into a steel die pattern by using a scraper to form the flexible circuit pattern, transferring the flexible circuit pattern to the first packaging layer 1 by using a transfer printing adhesive head, and heating and sintering to form the flexible circuit 2.
If a microchip is to be implanted and connected to the flexible circuit 2, the microchip is implanted into the flexible circuit 2 at a corresponding location after the flexible circuit 2 is sintered.
The conductive colloid is silver conductive colloid, and the conductive silver colloid is adopted in the invention, and it should be understood that the conductive silver colloid is only a typical material provided by the invention. The silver colloid is a conductive material with simple configuration, convenient use and excellent performance, and has a certain mature commercial product. Other conductive colloids, such as copper paste and graphene dispersion paste, also belong to the protection scope of the present application.
Step 3, preparing a second encapsulation layer 3
Pouring a colloidal packaging material into the contact lens outer mold carrying the first packaging layer 1 and the flexible circuit 2, uniformly hanging the packaging colloid on the surfaces of the first packaging layer 1 and the flexible circuit 2 through swinging and inclined flow control, and heating and curing the packaging material to form the second packaging layer 3.
And pouring contact lens materials into the contact lens outer mold bearing the first packaging layer 1, the flexible circuit 2 and the second packaging layer 3, pressing the contact lens inner mold into the contact lens outer mold, fixing the contact lens inner mold and the contact lens outer mold by using an adhesive tape, and heating and curing the contact lens materials to form the contact lens layer 4. The contact lens material is a commercial contact lens material based on silicone hydrogel.
The intelligent contact lens is taken out and soaked in PBS buffer solution for swelling.
At present, the commercial contact lens material contains a PDMS component, and PDMS is used as a material of a flexible circuit packaging layer, so that the mechanical modulus matching of a flexible circuit and the contact lens can be ensured to the maximum extent while water is prevented. Other elastomer materials, such as Ecoflex, silicone, etc., can also be used as the encapsulation material for the flexible circuit of the present invention.
Claims (5)
1. An intelligent contact lens containing a flexible circuit is characterized by comprising a first packaging layer, the flexible circuit, a second packaging layer and a contact lens layer which are sequentially arranged, wherein the second packaging layer is positioned on one side, back to eyes, of the contact lens layer.
2. The smart contact lens comprising a flexible circuit of claim 1, wherein the first encapsulant layer and the second encapsulant layer are made of the same material and are both an elastomer material.
3. The smart contact lens with the flexible circuit as claimed in claim 2, wherein the first and second encapsulating layers are made of PDMS, Ecoflex or silicone.
4. A method of making a smart contact lens containing a flexible circuit according to claim 1, comprising the steps of:
step 1, preparing a first packaging layer;
pouring a colloid-shaped packaging material into the outer mold of the contact lens, uniformly hanging the colloid on the wall of the outer mold of the contact lens through swinging and inclined flow control, and heating and curing the packaging material to form a first packaging layer;
step 2, preparing a flexible circuit;
coating a conductive adhesive on a steel die with a flexible circuit reverse die to fully fill the conductive adhesive into the steel die pattern to form a flexible circuit pattern, transferring the flexible circuit pattern to a first packaging layer by using a transfer printing adhesive head, and heating and sintering to form a flexible circuit;
step 3, preparing a second packaging layer
Pouring a colloidal packaging material into a contact lens outer mold bearing the first packaging layer and the flexible circuit, uniformly hanging the packaging colloid on the surfaces of the first packaging layer and the flexible circuit through swinging and inclined flow control, and heating and curing the packaging material to form a second packaging layer;
step 4, preparing the contact lens layer
And pouring a contact lens material into a contact lens outer mold bearing the first packaging layer, the flexible circuit and the second packaging layer, pressing the contact lens inner mold into the contact lens outer mold, fixing the contact lens inner mold and the contact lens outer mold, and heating and curing the contact lens material to form the contact lens layer.
5. The method of claim 4, wherein the conductive adhesive in step 2 is silver conductive adhesive.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210013801.6A CN114280815A (en) | 2022-01-07 | 2022-01-07 | Intelligent contact lens containing flexible circuit and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210013801.6A CN114280815A (en) | 2022-01-07 | 2022-01-07 | Intelligent contact lens containing flexible circuit and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114280815A true CN114280815A (en) | 2022-04-05 |
Family
ID=80880770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210013801.6A Pending CN114280815A (en) | 2022-01-07 | 2022-01-07 | Intelligent contact lens containing flexible circuit and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114280815A (en) |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1675575A (en) * | 2002-08-09 | 2005-09-28 | E-视觉有限公司 | Electro-active contact lens system |
| CN103543537A (en) * | 2012-07-13 | 2014-01-29 | 纳米新能源（唐山）有限责任公司 | Contact lens |
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| KR20180053894A (en) * | 2016-11-14 | 2018-05-24 | 울산과학기술원 | Smart contact lens including stretchable hybrid substrate and manufacturing method of the same |
| CN108778699A (en) * | 2016-03-03 | 2018-11-09 | 威里利生命科学有限责任公司 | The electronic device of embedded rigid gas permeable lens |
| JP2019128576A (en) * | 2018-06-11 | 2019-08-01 | 真一 芦田 | Utensil for eye, object to be held, and holding body |
| CN110455443A (en) * | 2019-08-23 | 2019-11-15 | 北京航空航天大学 | A kind of flexible capacitive sensor and preparation method thereof using the preparation of silver nanowires flexible electrode |
| TW202021790A (en) * | 2018-11-30 | 2020-06-16 | 精能光學股份有限公司 | Injection molding process for dual-material soft contact lenses including preparing materials, casting mold and forming, curing and shaping, and post-demoulding processing |
| CN112201408A (en) * | 2020-09-24 | 2021-01-08 | 复旦大学 | Preparation method of flexible transparent conductive film |
| CN112612144A (en) * | 2020-12-21 | 2021-04-06 | 浙江清华柔性电子技术研究院 | Contact lens structure and manufacturing method thereof |
| CN112630990A (en) * | 2020-12-21 | 2021-04-09 | 浙江清华柔性电子技术研究院 | Intelligent contact lens and preparation method thereof |
-
2022
- 2022-01-07 CN CN202210013801.6A patent/CN114280815A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1675575A (en) * | 2002-08-09 | 2005-09-28 | E-视觉有限公司 | Electro-active contact lens system |
| CN103543537A (en) * | 2012-07-13 | 2014-01-29 | 纳米新能源（唐山）有限责任公司 | Contact lens |
| CN106415373A (en) * | 2014-06-13 | 2017-02-15 | 威里利生命科学有限责任公司 | Flexible conductor for use within a contact lens |
| CN105592640A (en) * | 2014-10-22 | 2016-05-18 | 中国科学院理化技术研究所 | Flexible printed circuit fabricating method |
| TW201621407A (en) * | 2014-12-04 | 2016-06-16 | 開眼光學研發股份有限公司 | Intelligent patch for contact lens |
| CN108778699A (en) * | 2016-03-03 | 2018-11-09 | 威里利生命科学有限责任公司 | The electronic device of embedded rigid gas permeable lens |
| KR20180053894A (en) * | 2016-11-14 | 2018-05-24 | 울산과학기술원 | Smart contact lens including stretchable hybrid substrate and manufacturing method of the same |
| JP2019128576A (en) * | 2018-06-11 | 2019-08-01 | 真一 芦田 | Utensil for eye, object to be held, and holding body |
| TW202021790A (en) * | 2018-11-30 | 2020-06-16 | 精能光學股份有限公司 | Injection molding process for dual-material soft contact lenses including preparing materials, casting mold and forming, curing and shaping, and post-demoulding processing |
| CN110455443A (en) * | 2019-08-23 | 2019-11-15 | 北京航空航天大学 | A kind of flexible capacitive sensor and preparation method thereof using the preparation of silver nanowires flexible electrode |
| CN112201408A (en) * | 2020-09-24 | 2021-01-08 | 复旦大学 | Preparation method of flexible transparent conductive film |
| CN112612144A (en) * | 2020-12-21 | 2021-04-06 | 浙江清华柔性电子技术研究院 | Contact lens structure and manufacturing method thereof |
| CN112630990A (en) * | 2020-12-21 | 2021-04-09 | 浙江清华柔性电子技术研究院 | Intelligent contact lens and preparation method thereof |
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