CN114224977A - 一种用于调理三高的中药及其制备方法 - Google Patents
一种用于调理三高的中药及其制备方法 Download PDFInfo
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- CN114224977A CN114224977A CN202210034121.2A CN202210034121A CN114224977A CN 114224977 A CN114224977 A CN 114224977A CN 202210034121 A CN202210034121 A CN 202210034121A CN 114224977 A CN114224977 A CN 114224977A
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明提出了一种用于调理三高的中药及其制备方法,涉及中药技术领域。一种用于调理三高的中药,包括以下重量份的组分:白桦茸20~40份、蛹虫草20~40份、朴松实15~25份、紫草15~25份、沙棘15~25份、六轴子10~20份、葛根10~25份、土木香10~18份、枸杞子10~15份、黄精8~15份、山楂5~10份和山药5~10份。本发明组分的粒度不同,可以缓慢且有层次的释放,对于三高患者具有很好的疗效,同时也能减低对人体内脏的负荷,可以广泛用于三高病症的预防和治疗。
Description
技术领域
本发明涉及中药技术领域,具体而言,涉及一种用于调理三高的中药及其制备方法。
背景技术
三高是指高血脂、高血压和高血糖;三高的主要病因是由于长时间的饮食问题,如饮食中脂类过多,醇类过多,同时又没有合理的运动促进脂类醇类的代谢导致体内脂类醇类物质逐渐增多;这些物质掺杂在血液中,使毛细血管堵塞,随着时间的推移,脂类醇类物质容易和体内游离的矿物质离子结合,形成血栓;血栓容易在血管的拐角处,或者瓶颈处堆积,钙化;同时血栓越来越多,使血管直径缩小;心脏为了保持足够的供血量,就会增加血压,造成高血压疾病;也可能是抽烟多,或酗酒过度,损及脾胃,健运失司,致使饮食不归正化。
现有技术中虽然有很多用于治疗糖尿病和三高的药物,但是这些药物仅仅只能用来稳定病情或者缓解症状,并且大部分情况下都要求患者长期服药。这不但为患者增加了经济负担,还容易因为长期服药而造成内脏器官损伤。因此,研发出一种副作用小且对三高有较好疗效的三高药物具有很大的经济和社会效应。
发明内容
本发明的目的在于提供一种用于调理三高的中药,此中药对于三高患者具有很好的疗效,同时也能减低对人体内脏的负荷。
本发明的另一目的在于提供一种用于调理三高的中药的制备方法,可以使得中药内的药性缓慢且有层次得释放。
本发明解决其技术问题是采用以下技术方案来实现的。
一方面,本申请实施例提供一种用于调理三高的中药,包括以下重量份的组分:白桦茸20~40份、蛹虫草20~40份、朴松实15~25份、紫草15~25份、沙棘15~25份、六轴子10~20份、葛根10~25份、土木香10~18份、枸杞子10~15份、黄精8~15份、山楂5~10份和山药5~10份。
另一方面,本申请实施例提供一种用于调理三高的中药的制备方法,包括以下步骤:将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根破碎成颗粒,水提2~3次,合并提取液经大孔吸附树脂纯化,纯化后的提取物经浓缩、干燥和制粒,过30~50目筛,得到物料a;将土木香、枸杞子、黄精、山楂和山药经水提2~4次、浓缩、干燥和制粒,过70~100目筛,得到物料b;将物料a、物料b、缓释助剂和填充物混合,制备成缓释药剂。
相对于现有技术,本发明的实施例至少具有如下优点或有益效果:
本发明的原料采用白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子、葛根、土木香、枸杞子、黄精、山楂和山药,起到温里平肝,理气扶正,调节人体血压、血脂和血糖的效果。采用中药材与缓释助剂进行结合,可以延长中药材的释放时间,降低患者服药后药效快速释放,对肝脏产生伤害。本发明中药材中加入缓释助剂,可以使得本产品用于三高的预防。
本发明将土木香、枸杞子、黄精、山楂和山药采用水提并制备成更细的物料,在药物中发挥相对快速释放的效果,起到健脾益肾、消食养胃和滋补肝肾的效果,进一步降低对肝脏的伤害;将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根经过水提和大孔树脂吸附,对活性分子进行进一步地提取,并制备成相对粒度更大的物料,达到缓慢释放的效果。
综上,本发明的制备方法可以使得药物缓慢且有层次的释放,对于三高患者具有很好的疗效,同时也能减低对人体内脏的负荷,可以广泛用于三高病症的预防和治疗。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚,下面将对本发明实施例中的技术方案进行清楚、完整地描述。实施例中未注明具体条件者,按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者,均为可以通过市售购买获得的常规产品。
需要说明的是,在不冲突的情况下,本申请中的实施例及实施例中的特征可以相互组合。下面将参考具体实施例来详细说明本发明。
一种用于调理三高的中药,包括以下重量份的组分:白桦茸20~40份、蛹虫草20~40份、朴松实15~25份、紫草15~25份、沙棘15~25份、六轴子10~20份、葛根10~25份、土木香10~18份、枸杞子10~15份、黄精8~15份、山楂5~10份和山药5~10份。
在本发明的一些实施例中,上述中药包括以下重量份的组分:白桦茸30~35份、蛹虫草25~35份、朴松实20~25份、紫草20~25份、沙棘15~20份、六轴子10~15份、葛根12~20份、土木香12~15份、枸杞子12~15份、黄精10~15份、山楂5~8份和山药5~8份。
在本发明的一些实施例中,上述中药包括以下重量份的组分:白桦茸32份、蛹虫草30份、朴松实20份、紫草22份、沙棘18份、六轴子12份、葛根15份、土木香13份、枸杞子15份、黄精12份、山楂5份和山药6份。
在本发明的一些实施例中,上述中药还包括缓释助剂和填充物。
在本发明的一些实施例中,上述缓释助剂包括壳聚糖5~8份、二甲基甲酰胺2~5份、螺旋藻2~5份、大豆磷脂3~6份、聚乳酸羟基乙酸溶液5~10份和乙醇凝胶溶液6~12份。
在本发明的一些实施例中,上述填充物包括糊精、淀粉、山梨醇和微晶纤维素中的一种或多种,填充物的重量份为5~20份。
一种用于调理三高的中药的制备方法,包括以下步骤:
将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根破碎成颗粒,水提2~3次,合并提取液经大孔吸附树脂纯化,纯化后的提取物经浓缩、干燥和制粒,过30~50目筛,得到物料a;
将土木香、枸杞子、黄精、山楂和山药经水提2~4次、浓缩、干燥和制粒,过70~100目筛,得到物料b;
将物料a、物料b、缓释助剂和填充物混合,制备成缓释药剂。
在本发明的一些实施例中,上述物料a和物料b的水提步骤中的料液比均为1:(10~15),干燥后的含水量≤5%。
在本发明的一些实施例中,上述大孔吸附树脂的型号为S-8,流速为2~2.5BV/h,大孔吸附树脂吸附后还可采用盐酸液洗脱。
在本发明的一些实施例中,上述缓释剂包括缓释片、缓释胶囊和缓释颗粒,方便不同人群的食用。
另外,本发明的原料还可以只经过清洗、干燥、破碎和装袋后作为茶包,作为三高患者的日常饮用茶,有助于预防和治疗高血压、高血脂和高血糖。
以下结合实施例对本发明的特征和性能作进一步的详细描述。
实施例1
一种用于调理三高的中药,包括以下中药材:白桦茸320g、蛹虫草300g、朴松实200g、紫草220g、沙棘180g、六轴子120g、葛根150g、土木香130g、枸杞子150g、黄精120g、山楂50g和山药60g;缓释助剂:壳聚糖60g、二甲基甲酰胺30g、螺旋藻50g、大豆磷脂30g、聚乳酸羟基乙酸溶液70g和乙醇凝胶溶液120g;填料:淀粉40g和糊精60g。
制备方法:将壳聚糖和二甲基甲酰胺氮气气氛下升温至120℃,保温5h,冷却至室温后过滤,真空干燥后加入螺旋藻和大豆磷脂,在1200r/min转速下搅拌20min,加入聚乳酸羟基乙酸溶液和乙醇凝胶溶液,继续搅拌2h,然后以12000r/min转速离心收集,水洗后冷冻干燥得到缓释助剂;将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根破碎成颗粒,加入12倍质量的水,大火烧开转小火,熬煮2h后收集提取液,往滤渣中加入13倍质量的水继续水提,收集合并两次的提取液,经S-8型大孔吸附树脂吸附纯化,提取液在孔吸附树脂中的流速为2BV/h,纯化后的提取物经浓缩和干燥,将含水量降低至5%以下,再进行制粒,过30目筛,得到物料a;将土木香、枸杞子、黄精、山楂和山药破碎成颗粒混合,加入13倍质量的水,水提4次,合并提取液进行、浓缩、干燥和制粒,过80目筛,得到物料b,物料b中的含水量也低于5%;将物料a、物料b、缓释助剂和填充物混合,压制成片,制备成缓释片。
实施例2
一种用于调理三高的中药,包括以下中药材:白桦茸320g、蛹虫草350g、朴松实250g、紫草250g、沙棘150g、六轴子100g、葛根120g、土木香120g、枸杞子120g、黄精100g、山楂50g和山药50g;缓释助剂:壳聚糖80g、二甲基甲酰胺50g、螺旋藻30g、大豆磷脂60g、聚乳酸羟基乙酸溶液100g和乙醇凝胶溶液60g;填料:淀粉20g和糊精30g。
制备方法:将壳聚糖和二甲基甲酰胺氮气气氛下升温至130℃,保温6h,冷却至室温后过滤,真空干燥后加入螺旋藻和大豆磷脂,在1300r/min转速下搅拌15min,加入聚乳酸羟基乙酸溶液和乙醇凝胶溶液,继续搅拌2h,然后以12000r/min转速离心收集,水洗后冷冻干燥得到缓释助剂;将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根破碎成颗粒,加入15倍质量的水,大火烧开转小火,熬煮2h后收集提取液,往滤渣中加入12倍质量的水继续水提,收集合并两次的提取液,经S-8型大孔吸附树脂吸附纯化,提取液在孔吸附树脂中的流速为2BV/h,纯化后的提取物经浓缩和干燥,将含水量降低至5%以下,再进行制粒,过50目筛,得到物料a;将土木香、枸杞子、黄精、山楂和山药破碎成颗粒混合,加入10倍质量的水进行水提,水提4次,合并提取液进行、浓缩、干燥和制粒,过100目筛,得到物料b,物料b中的含水量也低于5%;将物料a、物料b、缓释助剂和填充物混合,包衣后装入空心药用胶囊,制备成缓释胶囊。
实施例3
一种用于调理三高的中药,包括以下中药材:白桦茸350g、蛹虫草250g、朴松实200g、紫草200g、沙棘200g、六轴子150g、葛根200g、土木香150g、枸杞子150g、黄精150g、山楂80g和山药80g;缓释助剂:壳聚糖50g、二甲基甲酰胺20g、螺旋藻20g、大豆磷脂30g、聚乳酸羟基乙酸溶液50g和乙醇凝胶溶液120g;填料:山梨醇30g和微晶纤维素120g。
制备方法:将壳聚糖和二甲基甲酰胺氮气气氛下升温至125℃,保温5h,冷却至室温后过滤,真空干燥后加入螺旋藻和大豆磷脂,在1250r/min转速下搅拌20min,加入聚乳酸羟基乙酸溶液和乙醇凝胶溶液,继续搅拌2h,然后以10000r/min转速离心收集,水洗后冷冻干燥得到缓释助剂;将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根破碎成颗粒,加入13倍质量的水,大火烧开转小火,熬煮3h后收集提取液,同样的步骤重复3次,收集合并三次的提取液,经S-8型大孔吸附树脂吸附纯化,提取液在孔吸附树脂中的流速为2BV/h,纯化后的提取物经浓缩和干燥,将含水量降低至5%以下,再进行制粒,过40目筛,得到物料a;将土木香、枸杞子、黄精、山楂和山药破碎成颗粒混合,加入10倍质量的水进行水提,水提4次,合并提取液进行、浓缩、干燥和制粒,过80目筛,得到物料b,物料b中的含水量也低于5%;将物料a、物料b、缓释助剂和填充物混合,经制粒机制备成缓释丸剂。
实施例4
一种用于调理三高的中药,包括以下中药材:白桦茸400g、蛹虫草200g、朴松实250g、紫草250g、沙棘150g、六轴子100g、葛根250g、土木香100g、枸杞子150g、黄精80g、山楂50g和山药50g;缓释助剂:壳聚糖80g、二甲基甲酰胺50g、螺旋藻20g、大豆磷脂40g、聚乳酸羟基乙酸溶液100g和乙醇凝胶溶液80g;填料:淀粉30g、糊精40g、山梨醇30g和微晶纤维素100g。
制备方法:将壳聚糖和二甲基甲酰胺氮气气氛下升温至120℃,保温6h,冷却至室温后过滤,真空干燥后加入螺旋藻和大豆磷脂,在1250r/min转速下搅拌30min,加入聚乳酸羟基乙酸溶液和乙醇凝胶溶液,继续搅拌3h,然后以8000r/min转速离心收集,水洗后冷冻干燥得到缓释助剂;将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根破碎成颗粒,加入10倍质量的水,大火烧开转小火,熬煮2h后收集提取液,同样的步骤重复3次,收集合并三次的提取液,经S-8型大孔吸附树脂吸附纯化,提取液在孔吸附树脂中的流速为2BV/h,纯化后的提取物经浓缩和干燥,将含水量降低至5%以下,再进行制粒,过30目筛,得到物料a;将土木香、枸杞子、黄精、山楂和山药破碎成颗粒混合,加入12倍质量的水进行水提,水提3次,合并提取液进行、浓缩、干燥和制粒,过90目筛,得到物料b,物料b中的含水量也低于5%;将物料a、物料b、缓释助剂和填充物混合,经制粒机制备成缓释丸剂。
实施例5
一种用于调理三高的中药,包括以下中药材:白桦茸200g、蛹虫草400g、朴松实150g、紫草150g、沙棘250g、六轴子200g、葛根100g、土木香180g、枸杞子100g、黄精150g、山楂100g和山药100g;缓释助剂:壳聚糖70g、二甲基甲酰胺25g、螺旋藻25g、大豆磷脂50g、聚乳酸羟基乙酸溶液80g和乙醇凝胶溶液80g;填料:淀粉30g、糊精80g和微晶纤维素20g。
制备方法:将壳聚糖和二甲基甲酰胺氮气气氛下升温至120℃,保温6h,冷却至室温后过滤,真空干燥后加入螺旋藻和大豆磷脂,在1250r/min转速下搅拌25min,加入聚乳酸羟基乙酸溶液和乙醇凝胶溶液,继续搅拌2.5h,然后以9000r/min转速离心收集,水洗后冷冻干燥得到缓释助剂;将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根破碎成颗粒,加入10倍质量的水,大火烧开转小火,熬煮2h后收集提取液,同样的步骤重复3次,收集合并三次的提取液,经S-8型大孔吸附树脂吸附纯化,提取液在孔吸附树脂中的流速为2BV/h,纯化后的提取物经浓缩和干燥,将含水量降低至5%以下,再进行制粒,过40目筛,得到物料a;将土木香、枸杞子、黄精、山楂和山药破碎成颗粒混合,加入13倍质量的水进行水提,水提3次,合并提取液进行、浓缩、干燥和制粒,过90目筛,得到物料b,物料b中的含水量也低于5%;将物料a、物料b、缓释助剂和填充物混合,包衣后装入空心药用胶囊,制备成缓释胶囊。
实施例6
一种用于调理三高的中药,包括以下中药材:白桦茸200g、蛹虫草400g、朴松实150g、紫草150g、沙棘250g、六轴子200g、葛根100g、土木香180g、枸杞子100g、黄精150g、山楂100g和山药100g。
制备方法:将各原料破碎成颗粒,加入12倍质量的水,大火烧开后转小火,熬煮2h后倒出滤液,往滤渣中再加入10倍质量的水,大火烧开后转小火,熬煮2h后倒出滤液;合并两次滤液,经浓缩、干燥和制粒后,制备成含水量低于5%的中药颗粒。
实施例7
本实施例与实施例1的区别在于,本实施例中的土木香、枸杞子、黄精、山楂和山药的处理方法同白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根,制粒的大小也相同。
实验例1
在实施例1~7中各取1各药品,按照《中国药典》2005年版二部附录XD释放度测定法中的第一法篮法装置测定体外释放度。以900mL pH1.2模拟胃液作为释放介质,置于温度37℃、转速100r/min的溶出仪转篮中,定时取样5mL,并补加同温同体积释放介质。样品经0.45μm微孔滤膜过滤后用高效液相色谱仪测定白桦茸和土木香的浓度,计算累积释放量,测试结果见表1和表2,其中表1为白桦茸的释放量,表2为土木香的释放量。
表1
表2
从表1和表2中可以看出,实施例1~5中的药品会以较快的速度释放颗粒小的物料b,同时以较慢的速度释放颗粒更大的物料a,物料b可以起到健胃补脾的效果,降低中药对于内脏的伤害。
自从2012年至今,对于三高患者,本发明实施例1~5的缓释药剂的有效率达到98%以上。
综上所述,本发明实施例的一种用于调理三高的中药及其制备方法。
本发明的原料采用白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子、葛根、土木香、枸杞子、黄精、山楂和山药,起到温里平肝,理气扶正,调节人体血压、血脂和血糖的效果。采用中药材与缓释助剂进行结合,可以延长中药材的释放时间,降低患者服药后药效快速释放,对肝脏产生伤害。本发明中药材中加入缓释助剂,可以使得本产品用于三高的预防应用。
本发明将土木香、枸杞子、黄精、山楂和山药采用水提并制备成更细的物料,在药物中发挥相对快速释放的效果,起到健脾益肾、消食养胃和滋补肝肾的效果,进一步降低对肝脏的伤害;将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根经过水提和大孔树脂吸附,对活性分子进行进一步地提取,并制备成相对粒度更大的物料,达到缓慢释放的效果。
综上,本发明的制备方法可以使得药物缓慢且有层次的释放,对于三高患者具有很好的疗效,同时也能减低对人体内脏的负荷,可以广泛用于三高病症的预防和治疗。
以上所描述的实施例是本发明一部分实施例,而不是全部的实施例。本发明的实施例的详细描述并非旨在限制要求保护的本发明的范围,而是仅仅表示本发明的选定实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
Claims (10)
1.一种用于调理三高的中药,其特征在于,包括以下重量份的组分:白桦茸20~40份、蛹虫草20~40份、朴松实15~25份、紫草15~25份、沙棘15~25份、六轴子10~20份、葛根10~25份、土木香10~18份、枸杞子10~15份、黄精8~15份、山楂5~10份和山药5~10份。
2.根据权利要求1所述的一种用于调理三高的中药,其特征在于,包括以下重量份的组分:白桦茸30~35份、蛹虫草25~35份、朴松实20~25份、紫草20~25份、沙棘15~20份、六轴子10~15份、葛根12~20份、土木香12~15份、枸杞子12~15份、黄精10~15份、山楂5~8份和山药5~8份。
3.根据权利要求2所述的一种用于调理三高的中药,其特征在于,包括以下重量份的组分:白桦茸32份、蛹虫草30份、朴松实20份、紫草22份、沙棘18份、六轴子12份、葛根15份、土木香13份、枸杞子15份、黄精12份、山楂5份和山药6份。
4.根据权利要求1所述的一种用于调理三高的中药,其特征在于,还包括缓释助剂和填充物。
5.根据权利要求4所述的一种用于调理三高的中药,其特征在于,所述缓释助剂包括壳聚糖5~8份、二甲基甲酰胺2~5份、螺旋藻2~5份、大豆磷脂3~6份、聚乳酸羟基乙酸溶液5~10份和乙醇凝胶溶液6~12份。
6.根据权利要求4所述的一种用于调理三高的中药,其特征在于,所述填充物包括糊精、淀粉、山梨醇和微晶纤维素中的一种或多种,填充物的重量份为5~20份。
7.一种如权利要求1~6任一项所述的用于调理三高的中药的制备方法,其特征在于,包括以下步骤:
将白桦茸、蛹虫草、朴松实、紫草、沙棘、六轴子和葛根破碎成颗粒,水提2~3次,合并提取液经大孔吸附树脂纯化,纯化后的提取物经浓缩、干燥和制粒,过30~50目筛,得到物料a;
将土木香、枸杞子、黄精、山楂和山药经水提2~4次、浓缩、干燥和制粒,过70~100目筛,得到物料b;
将物料a、物料b、缓释助剂和填充物混合,制备成缓释药剂。
8.根据权利要求7所述的一种用于调理三高的中药的制备方法,其特征在于,所述物料a和物料b的水提步骤中的料液比均为1:(10~15),干燥后的含水量≤5%。
9.根据权利要求7所述的一种用于调理三高的中药的制备方法,其特征在于,所述大孔吸附树脂的型号为S-8,流速为2~2.5BV/h,大孔吸附树脂吸附后还采用盐酸液洗脱。
10.根据权利要求7所述的一种用于调理三高的中药的制备方法,其特征在于,所述缓释剂包括缓释片、缓释胶囊和缓释颗粒。
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