CN114199631A - Amplification method for immunochromatography monitoring signal - Google Patents

Amplification method for immunochromatography monitoring signal Download PDF

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Publication number
CN114199631A
CN114199631A CN202111514136.0A CN202111514136A CN114199631A CN 114199631 A CN114199631 A CN 114199631A CN 202111514136 A CN202111514136 A CN 202111514136A CN 114199631 A CN114199631 A CN 114199631A
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China
Prior art keywords
suction
plate
rod
pressing
clamping
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Granted
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CN202111514136.0A
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CN114199631B (en
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叶肖俊
吴立江
郑水娣
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Hangzhou Laihe Biotech Co ltd
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Hangzhou Laihe Biotech Co ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices

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  • Life Sciences & Earth Sciences (AREA)
  • Hydrology & Water Resources (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention discloses an amplification method for an immunochromatography monitoring signal, which comprises the following steps: A. performing accounting extraction on the solvent by using a solution suction device; B. the user holds the suction tube pen by hand and puts the thumb above the pressing suction plate; C. the pressing suction plate drives the suction head to move downwards through the lifting rotating structure and the control structure, and the suction head is driven to reset through the lifting rotating structure and the control structure after the solvent is extruded outwards from the suction head by the pressing suction plate; D. the rotary reversing disc drives the plurality of suction heads to rotate, so that the suction heads are replaced; E. repeating the steps A-D; F. putting the extracted reagent into an RPA constant-temperature amplification instrument for amplification; G. when all the suction heads are used, the power structure is started, the power structure can drive the baffle structure to move, all the suction heads are made to move downwards, all the suction heads suck in cleaning liquid and extrude the cleaning liquid at the same time, and the suction heads are cleaned.

Description

Amplification method for immunochromatography monitoring signal
Technical Field
The invention belongs to the technical field of solvent extraction, and particularly relates to an amplification method for an immunochromatography monitoring signal.
Background
The immunochromatography monitoring signal amplification needs to be firstly subjected to check extraction and then put into an amplification instrument for amplification, but the existing nucleic acid extraction technology mainly uses a similar laboratory pipette for extraction when being operated manually, the pipette needs to be cleaned after each extraction, the cleaning time is long, the overall extraction efficiency is low, and the rapid nucleic acid extraction is not facilitated.
Disclosure of Invention
The invention provides an amplification method for an immunochromatography monitoring signal, which overcomes the defects of the prior art and can intensively clean and continuously perform check extraction.
In order to achieve the purpose, the invention adopts the following technical scheme: an amplification method for immunochromatographic monitoring signals, comprising the steps of:
A. performing accounting extraction on the solvent by using a solution suction device; the solution suction device comprises a suction tube pen, a pressing suction plate arranged above the suction tube pen, a baffle structure arranged below the suction tube pen, a first pressure rod fixedly arranged below the pressing suction plate, a suction tube inner core fixedly arranged below the first pressure rod and positioned inside the suction tube pen, a lifting rotating structure connected with the pressing suction plate, a control structure connected with the lifting rotating structure, a suction head connected with the control structure for extraction, and a power structure arranged below the suction tube inner core and connected with the baffle structure;
B. a user holds the pipette pen with a hand, puts a thumb above the pressing suction plate, then presses the pressing suction plate downwards, the pressing suction plate can move downwards, the pressing suction plate is not loosened, the lifting rotating structure and the baffle structure can be driven to move in the downward movement of the pressing suction plate, then the baffle structure can block all the pipette heads at first, the pipette heads are protected, the baffle structure can be opened by pressing the pressing suction plate downwards, one pipette head can move downwards, so that the pipette heads can be taken out of the baffle structure, then the position of the pipette pen is moved, the pipette heads reach the reagent box and are placed in the reagent box, then the pressing suction plate is loosened, the reagent can be extracted, the pipette pen is moved to the position where the reagent needs to be discharged outwards, the suction plate is pressed again, and the solvent in the pipette heads can be extruded outwards;
C. the pressing suction plate drives the suction head to move downwards through the lifting rotating structure and the control structure, and after the pressing suction plate finishes extruding the solvent out of the suction head, the lifting rotating structure and the control structure drive the suction head to reset, so that the suction head returns to the position above the baffle structure again for protection; the control structure comprises a third pressure rod connected with the lifting rotating structure, a guide plate fixedly connected with the straw pen, a rotating reversing disc rotatably arranged on the guide plate, a first chute arranged on the rotating reversing disc, a guide component connected with the first chute, a first clamping component and a second clamping component connected with the guide component, a rotating motor fixedly arranged above the rotating reversing disc and fixedly connected with the straw inner core, and a connecting hose connected with the straw inner core and communicated with the straw inner core; the suction head comprises a first sliding block connected with the guide assembly and matched with the third pressure lever and a connecting cavity fixedly connected with the first sliding block; the suction head is fixedly connected with the connecting cavity; the first sliding block is communicated with the connecting hose; the connecting cavity is communicated with the first sliding block; the method comprises the following steps: the pressing suction plate moves downwards to drive the third pressing rod to move downwards through the lifting and rotating structure, then the first downward movement of the third pressing rod can press the first sliding block downwards to move downwards, the first sliding block can move under the guide of the guide assembly, then the first sliding block drives the suction head to move downwards through the connecting cavity, then the pressing suction plate is pressed to reduce the air in the suction pipe inner core, then the pressing suction plate loosens hands, the pressing suction plate can move upwards, namely reagent is sucked into the suction head through the suction pipe inner core, the first sliding block and the suction plate, then the pressing suction plate can be pressed downwards again to extrude the reagent in the suction head outwards, namely the pressing suction plate drives the third pressing rod to move downwards once, then the third pressing rod moves upwards once again, at the moment, the third pressing rod can move under the action of the lifting and rotating structure, the third pressure rod can be matched with the first clamping component, so that the pressing suction plate is pressed downwards for the first time and only drives the suction head to move downwards, the second time of pressing downwards is used for extruding the reagent in the suction head outwards, the third pressure rod can be matched with the first clamping component, then the pressing suction plate is loosened and can move upwards, the pressing suction plate can drive the third pressure rod to move upwards through the lifting rotating structure, namely the third pressure rod can drive the suction head to move upwards through the first clamping component, and the suction head can be reset upwards above the baffle structure after each use is finished;
D. the rotary reversing disc drives the plurality of suction heads to rotate, so that the suction heads are replaced, and the unused suction heads are replaced and matched with the lifting rotating structure and the control structure;
E. repeating the steps A-D;
F. putting the extracted reagent into an RPA constant-temperature amplification instrument for amplification;
G. when all the suction heads are used, the power structure is started, the power structure can drive the baffle structure to move, all the suction heads are made to move downwards, all the suction heads suck in cleaning liquid and extrude the cleaning liquid at the same time, and the suction heads are cleaned.
The invention is mainly provided with a plurality of suction heads which can be used in turn, because the suction heads can remain solution after being used once under normal conditions, which is not beneficial to the accuracy of the subsequent extraction of the suction heads, generally, cleaning liquid is sucked and squeezed out for a plurality of times after the suction heads are extracted once, so that the suction heads are cleaned, which can lead to the cleaning for a long time after the reagent is extracted each time, thereby leading to the reduction of the extraction speed, and the amplification speed can be reduced along with the reduction of the amplification speed, thereby being not beneficial to the rapid amplification, and then the invention can be used in turn by pressing the suction plates of the plurality of suction heads, and can be replaced to another suction head for extraction after the extraction of one suction head is finished, thereby, in other words, when the extraction is carried out for a plurality of times, the clean suction heads can be used each time without cleaning, thereby avoiding the waste of cleaning time, the extraction speed is greatly improved, so that the extracted solvent can be quickly amplified, the amplification speed can be better improved, then, the gapless extraction can be carried out, the solvent can be quickly extracted and put into an amplification instrument, namely, the time of the solvent exposed in the outside air is greatly reduced, so that the solvent can better keep the activity of the solvent and can be put into the amplification instrument without being polluted by the outside, the protection on the reagent is greatly improved, the amplification precision is greatly improved, the outside influence is reduced, the detection effect after the amplification is better improved, then, after each suction head is used, all the suction heads can be outside, then, the solvent is sucked together, the solvent is extruded, and thus, the solvent can be better and quickly cleaned, therefore, the utility model can be put into new use quickly and subsequently, and the use efficiency is greatly improved.
Furthermore, the guide assembly comprises a first support plate fixedly connected to the rotary reversing disc, a first guide rod fixedly connected to the first support plate, a first compression spring arranged below the first sliding block and above the first support plate and used for enabling the first sliding block to reset rapidly, a clamping groove arranged on the first sliding block, and a first clamping arc-shaped block matched with the clamping groove and used for clamping the first sliding block; the second clamping assembly comprises a third supporting plate fixedly arranged on the first supporting plate, a threaded rod rotatably connected to the third supporting plate and the rotary reversing disc, a first gear fixedly connected to the threaded rod, a rack fixedly connected to the first sliding block and matched with the first gear, a nut in threaded connection with the threaded rod, a guide block fixedly connected to the nut, a first telescopic rod fixedly connected to the guide block and the first clamping arc-shaped block, and a guide assembly power structure arranged between the first clamping arc-shaped block and the guide block and used for enabling the first clamping arc-shaped block to reset; the method comprises the following specific steps: the first sliding block moves downwards to drive the rack to move downwards, then the first sliding block descends to a certain height to drive the rack to be meshed with the first gear, then the first sliding block continues to move downwards, so that the rack can drive the first gear to rotate, and then the first gear can drive the threaded rod to rotate, so that the rotation of the threaded rod drives the nut to move, the nut is close to the first sliding block to move, then the nut drives the guide block to move, namely the distance between the guide block and the first clamping arc-shaped block becomes shorter, then when the first sliding block moves to the lowest part, the clamping groove and the first clamping arc-shaped block are in the same horizontal position, the guide assembly can be embedded into the clamping groove, so that the clamping position of the clamping groove is clamped, namely the position of the first sliding block is fixed, and the first sliding block cannot move upwards under the action of the first compression spring to reset;
the first sliding block is mainly clamped by the first clamping arc-shaped block and the clamping groove, so that after the first pressing of the pressing suction plate is realized, the first sliding block cannot be driven to reset when the pressing suction plate is reset, namely, the suction head cannot be driven to reset, so that the first pressing and releasing of the pressing suction plate are ensured, the suction head can be always positioned below the baffle structure, the suction head can normally suck the solvent, the use stability is better improved, then, the first sliding block moves downwards, when the first sliding block moves to a certain position, namely, when the distance between the lowest part of the first sliding block and the first clamping arc-shaped block is very short, the first clamping arc-shaped block is still positioned at the original position and does not move, then, the first sliding block continues to move downwards, the first sliding block is matched with the first clamping arc-shaped block, namely, the first clamping arc-shaped block can be abutted against the surface of the first sliding block, then the rack is meshed with the first gear, so that the nut and the guide block move towards the direction close to the first sliding block, then the guide block can increase the pressure on the first clamping arc-shaped block through the first telescopic rod, then when the first clamping arc-shaped block is embedded in the clamping groove, the distance between the guide block and the first sliding block is greatly reduced, so that the first clamping arc-shaped block can be more closely attached to the clamping groove under the action of the first telescopic rod, the effect of the first clamping arc-shaped block for clamping the first sliding block is better, the original distance between the guide block and the first sliding block is further realized, so that the first sliding block moves downwards, and after the guide block moves to the position of the first clamping arc-shaped block, the first sliding block can well pass through the first clamping arc-shaped block, and make the cambered surface on the first screens arc piece can be better lead to first sliding block, also be that first sliding block makes first screens arc piece slide on the surface of first sliding block, and because the position of first sliding block and guide block is originally than far away, so also be that first sliding block moves below can not be that first telescopic link is compressed a lot, later when first screens arc piece inlays in the screens groove, but compressed a lot, thereby also be that first telescopic link can slowly be compressed, thereby the better effect that first screens arc piece blocks first sliding block of assurance that can also be better when having guaranteed first telescopic link's life.
Furthermore, the first clamping assembly comprises a second support plate fixedly arranged on the first sliding block, a second telescopic rod fixedly arranged on the second support plate, a second clamping arc-shaped block fixedly arranged on the second telescopic rod, a third reset spring fixedly arranged between the second support plate and the second clamping arc-shaped block, a third connecting rod fixedly arranged on the second clamping arc-shaped block, a fourth connecting rod hinged to the third connecting rod, a lifting plate hinged to the fourth connecting rod and slidably connected to the first sliding block, and a position control clamping plate fixedly connected to the third pressing rod and matched with the two second clamping arc-shaped blocks; the lifting plate can only slide in the vertical direction of the first sliding block; the lifting plate can be matched with the first clamping arc-shaped block; the method comprises the following specific steps: the third pressure lever moves downwards to enable the position control clamping plate to drive the first sliding block to move downwards, and when the third pressure lever is pressed for the first time, the position control clamping plate is positioned on the opposite surface of the second clamping arc-shaped block, namely the position control clamping plate and the second clamping arc-shaped block form an angle of one hundred eighty degrees, then the third pressure lever can not enable the position control clamping plate to be matched with the second clamping arc-shaped block when the third pressure lever is reset, so that the pressing suction plate is pressed for the first time and the pressing suction plate is reset for the first time, the first sliding block only realizes downward movement and is clamped at the position, then when the pressing suction plate is pressed downwards for the second time, the position control clamping plate is positioned at the position capable of being matched with the second clamping arc-shaped block, then the position control clamping plate moves downwards to the position above the second clamping arc-shaped block to drive the two second clamping arc-shaped blocks to move towards two sides, then the position control clamping plate moves to the position below the second clamping arc-shaped block, and then the second clamping arc-shaped block can reset under the action of the third reset spring, thereby clamping the position control clamping plate, the shape of the position control clamping plate is that the lower part is big, the upper part is small, namely a top position block is arranged above the position control clamping plate, therefore, the original positions of the second blocking arc-shaped blocks are mutually abutted, and then the position control clamping plate moves to the lower part, namely the two second blocking arc-shaped blocks are abutted on the top position block, therefore, the distance between the two second clamping arc-shaped blocks can be increased, so that the second clamping arc-shaped blocks can move compared with the position control clamping plate before the position control clamping plate comes down, namely the second clamping arc-shaped blocks drive the second telescopic rod to move, then the second clamping arc-shaped blocks can drive the third connecting rod to move towards the directions of two sides, then the third connecting rod can drive the lifting plate to move downwards through the fourth connecting rod, then the lifting plate can be enabled to prop against the first clamping arc-shaped blocks, and then the lifting plate can be enabled to push the first clamping arc-shaped blocks outwards under the action of the cambered surfaces of the first clamping arc-shaped blocks;
the first clamping arc-shaped block is outwards ejected by the lifting plate, namely the first clamping arc-shaped block moves outwards, the size of the first clamping arc-shaped block embedded in the clamping groove is reduced, the degree of the first clamping arc-shaped block clamping the first sliding block is reduced, the provided force for fixing the first sliding block at the position is also reduced, the suction plate is pressed for the second time to be released, namely the suction plate is pressed for the second time to reset, the second clamping arc-shaped block is driven to move by the position control clamping plate, so that the second clamping arc-shaped block can drive the first sliding block to reset upwards through the second telescopic rod and the second support plate, the first sliding block can also receive the upwards force from the first compression spring, and the resultant force for blocking reset when the first sliding block resets is reduced, later first screens arc piece inlays the volume reduction in the screens groove to further messenger hinders the resultant force that resets and reduces, thereby can be better make press the suction plate and carry out the second time when resetting drive first sliding block reset, also can be better make the suction head reset and get back to the top of baffle structure, thereby improved the stability of using.
Furthermore, the suction head also comprises a fourth gear fixedly arranged below the guide plate, a second rotating shaft rotatably arranged on the connecting cavity, a fifth gear fixedly connected to the second rotating shaft and meshed with the fourth gear, and a fan blade fixedly arranged below the second rotating shaft and positioned in the connecting cavity; the degree of each rotation of the rotary reversing disc is integral multiple of forty-five degrees; eight suction heads are arranged in total; the rotary reversing disc controls the suction head to rotate forty-five degrees each time when the suction head is replaced; when the suction head is cleaned, the degree of rotation of the rotary reversing disc is integral multiple of forty-five degrees; the method comprises the following specific steps: rotatory reversing disc rotation can drive the suction head and rotate, and later fourth gear position is fixed, also the fifth gear can rotate on the fourth gear, later can make the flabellum take place to rotate, and the flabellum can blow to suction head inside, can make the inside better keeping dry of suction head, can not have the water droplet to influence the result of drawing to the efficiency of better assurance amplification.
Furthermore, the lifting and rotating structure comprises a second pressure rod fixedly arranged below the pressing suction plate, a lifting rotating ring fixedly connected to the second pressure rod, a connecting ring rotatably connected to the lifting rotating ring, a third gear fixedly connected to the third pressure rod, a rotating guide plate fixedly connected to the lifting rotating ring, a second gear fixedly connected to the rotating guide plate and meshed with the third gear, a second sliding groove arranged in the lifting rotating ring, and a second guide rod fixedly connected to the straw inner core and slidably connected to the second sliding groove; the lifting rotating ring is arranged in the straw pen in a sliding manner; the connecting ring moves up and down along with the lifting rotating ring; the connecting ring is connected with the straw pen in a sliding mode and cannot rotate; the third pressure rod is rotatably connected to the connecting ring; the method comprises the following specific steps: the pressing suction plate is pressed downwards, the second pressure rod is driven to move downwards, then the second pressure rod drives the lifting rotating ring to move downwards, then the lifting rotating ring drives the connecting ring to move downwards, then the connecting ring can enable the third pressure rod to move downwards, then the lifting rotating ring can rotate under the action of the second sliding groove and the second guide rod when moving downwards, then the lifting rotating ring can drive the rotating guide plate to rotate, the rotating guide plate drives the second gear to rotate, then the connecting ring does not rotate, so that the third pressure rod does not revolve around the lifting rotating ring, the third pressure rod can never change in one position, then the third gear is a one-way gear, the second gear rotates to drive the third gear to rotate, and then the third gear drives the third pressure rod to rotate;
then the length of each downward movement of the lifting rotating ring is the same, namely the angle of each rotation of the third pressure rod is the same, then the angle of each rotation of the third pressure rod is one hundred eighty degrees, so that the third pressure rod can rotate by pressing the pressing suction plate downwards, when the pressing suction plate is reset, the third pressure rod can not rotate under the action of the one-way gear, then when the pressing suction plate is pressed for the first time, the third pressure rod rotates, so that the position control clamping plate on the third pressure rod is not matched with the second clamping arc-shaped block, then the suction plate is pressed for the second time, the third pressure rod can rotate again, then the position control clamping plate on the third pressure rod is positioned at the position where the position control clamping plate can be matched with the second clamping arc-shaped block, and therefore the first pressing of the pressing suction plate can drive the suction head to move downwards, pressing the pressing suction plate downwards for the second time to enable the pressing suction plate to be connected with the suction head, and driving the suction head to reset; later the third depression bar can reach the deflector top when reseing at every turn to can not influence the normal more position and the rotation of suction head, be equipped with the curved surface on the cardboard of later accuse position, also be exactly that accuse position cardboard drives first sliding block and breaks away from after first screens arc piece, first sliding block resets to the top, later accuse position cardboard continues to reset, can throw off second screens arc piece under the effect of curved surface, thereby can not influence the transposition of suction head.
Furthermore, the baffle structure comprises a chassis fixedly arranged below the straw pen, a plurality of first avoidance holes arranged on the chassis and matched with the suction head, a plurality of dustproof plates arranged on the baffle structure in a sliding manner and used for blocking the first avoidance holes, a first connecting rod hinged to the dustproof plates, a second connecting rod hinged to the first connecting rod, a rotating disk rotatably arranged below the chassis and hinged to the second connecting rod, and a first rotating shaft fixedly connected to the rotating disk and rotatably connected to the chassis and used for guiding the rotating disk; seven dustproof plates are arranged; eight first avoiding holes are formed; a dustproof movable plate is arranged at the first position avoiding hole positioned below the third pressure rod; the dustproof movable plate and the dustproof plate are in the same position relation and connection relation; the method comprises the following specific steps: when a plurality of dust-proof plates are required to be opened simultaneously, the power structure is started, the first rotating shaft can be rotated, the rotating disk is driven to rotate, then the rotating disk drives the second connecting rod and the first connecting rod to move, the dust-proof plates can move towards the centripetal direction, then the seven dust-proof plates can not block the first avoidance holes, the connection relation between the dust-proof plates is the same, the dust-proof plates can move towards the centripetal direction, the eight first avoidance holes can not be blocked, and at the moment, the suction head can move completely downwards to clean the dust-proof plates.
Furthermore, the power structure comprises a driving motor fixedly connected with the suction pipe inner core, a winding disc fixedly connected with the driving motor, a power structure baffle structure connected with the driving motor, and a rope wound on the winding disc and penetrating through the chassis and connected with the fourth gear; when all the suction heads are used once, the driving motor can drive the winding disc to rotate, then the driving motor can drive the first rotating shaft to rotate through the baffle structure of the power structure, then the driving motor drives the winding disc to rotate, the rope can be wound on the winding disc, thereby pulling the rope, and the fourth gear is pulled to move downwards by the rope, and then the fourth gear is positioned above the connecting cavity, so that the downward movement of the fourth gear can drive the suction heads to move downward, and a plurality of suction heads can simultaneously move downward for a certain distance, so that all the suction heads can reach the lower part of the baffle plate structure, and when the suction heads are cleaned later, can be whole wash all suction heads, improved abluent efficiency, distinguish first pivot and the rotation of coiling dish through power structure baffle structure, better two movements can not appear the conflict, have improved the stability of motion.
Furthermore, the dustproof movable plate comprises a third sliding chute arranged below the dustproof movable plate, an extension spring arranged in the third sliding chute, a fourth sliding chute arranged on the chassis, a first sliding rod fixedly connected to the dustproof movable plate and slidably connected to the fourth sliding chute, a second sliding rod fixedly connected to the second connecting rod and slidably arranged in the third sliding chute and connected to the extension spring, a through hole arranged on the chassis and communicated with the fourth sliding chute, a telescopic pipe fixedly arranged above the through hole, and a plurality of sections of telescopic rods fixedly arranged below the first sliding block and matched with the telescopic pipe; the structure of the dustproof plate is similar to that of the dustproof movable plate; both are provided with a first sliding rod and a fourth sliding chute matched with the first sliding rod; the method comprises the following specific steps: the first sliding block moves downwards to drive the multiple sections of telescopic rods to move downwards, then the multiple sections of telescopic rods reach the telescopic pipes, then the multiple sections of telescopic rods stretch and retract, so that air in the telescopic pipes can be squeezed into the fourth sliding groove, then the air in the fourth sliding groove can push the first sliding rod to move towards the centripetal direction, then the first sliding rod drives the dustproof movable plate to move towards the centripetal direction, so that the dustproof movable plate opens the first avoiding hole, the suction head can move to the lower part of the chassis, then the telescopic pipes are longer in length, then the multiple sections of telescopic rods can stretch and retract, so that the multiple sections of telescopic rods can compress air in the telescopic pipes after the first sliding block moves downwards for a certain position, and then enough air pressure in the fourth sliding groove can push the first sliding rod to move, the rear multi-section telescopic rod can be shortened to protect the first sliding rod, so that only one suction head is used at ordinary times.
Further, the connecting hose comprises a first connecting bin connected with the straw inner core; the first connecting bin is communicated with the straw inner core; the inner core of the straw is not explained in the prior art.
In conclusion, the invention can enable a plurality of suction heads to be used in turn by arranging the lifting and rotating structure and the control structure, namely, each suction head can be better kept in a clean state when being used, and the amplification effect is better ensured; the baffle plate structure and the power structure are arranged, a plurality of suction heads can be cleaned simultaneously, the cleaning speed is improved, the suction heads are protected through the baffle plate structure, pollution is avoided, and the amplification effect is further improved.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of a reset structure of the baffle structure of the present invention;
FIG. 3 is a schematic structural view of a baffle structure according to the present invention;
FIG. 4 is a schematic structural diagram of a control structure according to the present invention;
FIG. 5 is a schematic structural view of the first sliding chute of the present invention;
FIG. 6 is an enlarged view of A of FIG. 5 according to the present invention;
FIG. 7 is an enlarged view of B of FIG. 6 in accordance with the present invention;
FIG. 8 is a schematic view of the lifter plate of the present invention;
FIG. 9 is a schematic side view of the positioning card of the present invention;
FIG. 10 is a schematic top view of the positioning card of the present invention;
FIG. 11 is a schematic view of the position structure of M-M in the present invention;
FIG. 12 is a schematic sectional view of M-M in the present invention;
FIG. 13 is an enlarged view of C of FIG. 12 in accordance with the present invention;
FIG. 14 is a schematic view of a second guide bar according to the present invention;
FIG. 15 is an enlarged view of D of FIG. 12 in accordance with the invention;
FIG. 16 is an enlarged view of E of FIG. 15 in accordance with the invention;
FIG. 17 is an enlarged view of F of FIG. 15 in accordance with the invention;
FIG. 18 is an enlarged view of G of FIG. 15 in accordance with the present invention;
FIG. 19 is a schematic diagram of the N-N position structure according to the present invention;
FIG. 20 is a schematic cross-sectional view of N-N in the present invention;
FIG. 21 is an enlarged view of H in FIG. 20 according to the present invention.
Detailed Description
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention.
As shown in fig. 1-21, an amplification method for immunochromatographic monitoring signals, comprising the steps of:
A. performing accounting extraction on the solvent by using a solution suction device; the solution suction device comprises a suction tube pen 1, a pressing suction plate 2 arranged above the suction tube pen 1, a baffle plate structure 3 arranged below the suction tube pen 1, a first pressure rod 21 fixedly arranged below the pressing suction plate 2, a suction tube inner core 22 fixedly arranged below the first pressure rod 21 and positioned inside the suction tube pen 1, a lifting and rotating structure 4 connected to the pressing suction plate 2, a control structure 6 connected to the lifting and rotating structure 4, a suction head 5 connected to the control structure 6 for extraction, and a power structure 7 arranged below the suction tube inner core 22 and connected to the baffle plate structure 3;
B. the user holds the pipette pen 1 by hand, puts the thumb above the pressing suction plate 2, then presses the pressing suction plate 2 downwards, the pressing suction plate 2 moves downwards, at the moment, the pressing suction plate 2 is not loosened, in the downward movement of the pressing suction plate 2, the lifting rotating structure 4 and the baffle structure 3 are driven to move, then the baffle structure 3 can block all the suction heads 5 at first, the suction heads 5 are protected, the pressing suction plate 2 presses downwards to open the baffle structure 3, one suction head 5 moves downwards, so that the suction head 5 comes out of the baffle structure 3, then the position of the pipette pen 1 is moved, the suction head 5 reaches the reagent box and is put in the reagent box, then the pressing suction plate 2 is loosened to extract the reagent, then the pipette pen 1 is moved to the position where the reagent needs to be discharged outwards, and the pressing suction plate 2 is pressed again, will push the solvent in the suction head 5 outwards;
C. the pressing suction plate 2 drives the suction head 5 to move downwards through the lifting and rotating structure 4 and the control structure 6, and after the pressing suction plate 2 finishes extruding the solvent out of the suction head 5, the lifting and rotating structure 4 and the control structure 6 drive the suction head 5 to reset, so that the suction head 5 returns to the upper part of the baffle structure 3 again for protection; the control structure 6 comprises a third pressure lever 61 connected with the lifting and rotating structure 4, a guide plate 62 fixedly connected with the straw pen 1, a rotary reversing disc 63 rotatably arranged on the guide plate 62, a first chute 631 arranged on the rotary reversing disc 63, a guide assembly 65 connected with the first chute 631, a first clamping assembly 66 and a second clamping assembly 67 connected with the guide assembly 65, a rotating motor 68 fixedly arranged above the rotary reversing disc 63 and fixedly connected with the straw inner core 22, and a connecting hose 64 connected with the straw inner core 22 and communicated with the straw inner core 22; the suction head 5 comprises a first sliding block 52 connected with the guide assembly 65 and matched with the third pressure lever 61, and a connecting cavity 51 fixedly connected with the first sliding block 52; the suction head 5 is fixedly connected with the connecting cavity 51; the first slide block 52 is in communication with the connection hose 64; the connecting cavity 51 is communicated with the first sliding block 52; the method comprises the following steps: the pressing suction plate 2 moves downwards to drive the third pressing rod 61 to move downwards through the lifting and rotating structure 4, then the third pressing rod 61 moves downwards for the first time to press the first sliding block 52 downwards, the first sliding block 52 moves under the guidance of the guiding component 65, then the first sliding block 52 drives the suction head 5 to move downwards through the connecting cavity 51, then the pressing suction plate 2 presses to reduce the air in the suction core 22, then the pressing suction plate 2 releases the hand, the pressing suction plate 2 moves upwards, namely, the reagent is sucked into the suction head 5 through the suction core 22, the connecting hose 64 and the first sliding block 52, then the pressing suction plate 2 presses downwards again to extrude the reagent in the suction head 5 outwards, namely, at this time, the pressing suction plate 2 drives the third pressing rod 61 to move downwards once and then moves upwards once, the third pressure lever 61 moves downwards once again, so that the third pressure lever 61 moves under the action of the lifting and rotating structure 4, that is, the third pressure lever 61 can be matched with the first clamping component 66, so that the pressing suction plate 2 is pressed downwards for the first time, and only the suction head 5 is driven to move downwards, the second downward pressing is performed to extrude the reagent in the suction head 5 outwards, and the third pressure lever 61 is matched with the first clamping component 66, then the pressing suction plate 2 is released, the pressing suction plate 2 moves upwards, at this time, the pressing suction plate 2 drives the third pressure lever 61 upwards through the lifting and rotating structure 4, that is, the third pressure lever 61 drives the suction head 5 to move upwards through the first clamping component 66, and the suction head 5 is reset upwards above the baffle structure 3 after each use;
D. the rotary reversing disc 63 drives the plurality of suction heads 5 to rotate, so that the suction heads 5 are replaced, and the unused suction heads 5 are replaced and matched with the lifting and rotating structure 4 and the control structure 6;
E. repeating the steps A-D;
F. putting the extracted reagent into an RPA constant-temperature amplification instrument for amplification;
G. when all the suction heads 5 are used, the power structure 7 is started, the power structure 7 drives the baffle structure 3 to move, then all the suction heads 5 move downwards, all the suction heads 5 suck in the cleaning liquid and extrude the cleaning liquid at the same time, and the suction heads 5 are cleaned.
The invention is mainly provided with a plurality of suction heads 5, then the plurality of suction heads 5 can be used in turn, because under normal conditions, the suction heads 5 can remain solution after being used once, which is not beneficial to the accuracy of the subsequent extraction of the suction heads 5, so that generally, cleaning liquid is sucked and squeezed out for a plurality of times after the suction heads 5 are extracted once, so that the suction heads 5 are cleaned, and then the cleaning is carried out for a long time after one reagent is extracted each time, thereby leading to the reduction of the extraction speed, and the amplification speed is reduced, thereby being not beneficial to the rapid amplification, then, the invention can be used in turn by pressing the suction plates 2 of the plurality of suction heads 5, and can be quickly replaced to another suction head 5 for extraction after the extraction of one suction head 5 is finished, namely, when the extraction is carried out for a plurality of times, the suction heads 5 can be used clean each time without being cleaned, thereby avoiding the waste of time for cleaning, greatly improving the extraction speed, rapidly amplifying the extracted solvent, and better improving the amplification speed, then extracting without gaps, quickly extracting the solvent and putting the solvent into an amplification instrument, greatly reducing the time of the solvent exposed in the outside air, better keeping the solvent active, putting the solvent into the amplification instrument without being polluted by the outside, greatly improving the protection of the reagent, greatly improving the amplification precision, reducing the influence of the outside, better improving the detection effect after amplification, and then sucking the solvent together with all the suction heads 5 when each suction head 5 is used up, and the solvent is extruded, so that the solvent can be better and quickly cleaned, and then the solvent is quickly put into new use, and the use efficiency is greatly improved.
Specifically, the guide assembly 65 includes a first support plate 651 fixedly connected to the rotary reversing disc 63, a first guide rod 652 fixedly connected to the first support plate 651, a first compression spring 653 disposed below the first sliding block 52 and above the first support plate 651 for rapidly resetting the first sliding block 52, a locking groove 654 disposed on the first sliding block 52, and a first locking arc-shaped block 655 fitted in the locking groove 654 for locking the first sliding block 52; the second blocking component 67 comprises a third support plate 675 fixedly arranged on the first support plate 651, a threaded rod 673 rotatably connected to the third support plate 675 and the rotary reversing disc 63, a first gear 672 fixedly connected to the threaded rod 673, a rack 671 fixedly connected to the first sliding block 52 and matched with the first gear 672, a nut 674 threadedly connected to the threaded rod 673, a guide block 676 fixedly connected to the nut 674, a first telescopic rod 678 fixedly connected to the guide block 676 and the first blocking arc-shaped block 655, and a guide component 65 power structure 7 arranged between the first blocking arc-shaped block 655 and the guide block 676 and used for resetting the first blocking arc-shaped block 655; the method comprises the following specific steps: the first sliding block 52 moves downwards to drive the rack 671 to move downwards, then the first sliding block 52 descends to a certain height to drive the rack 671 to be meshed with the first gear 672, then the first sliding block 52 moves downwards continuously, so that the rack 671 drives the first gear 672 to rotate, then the first gear 672 drives the threaded rod 673 to rotate, so that the threaded rod 673 rotates to drive the nut 674 to move, so that the nut 674 approaches the first sliding block 52, then the nut 674 drives the guide block 676 to move, so that the distance between the guide block 676 and the first blocking arc-shaped block 655 becomes shorter, then when the first sliding block 52 moves to the lowest position, the blocking groove 654 and the first blocking arc-shaped block 655 are at the same horizontal position, so that the guide assembly 65 can be embedded into the blocking groove 654 to block the blocking groove 654, that is, the position of the first slide block 52 is fixed, so that the first slide block 52 cannot be returned to the upward movement by the first compression spring 653.
Specifically, the first blocking assembly 66 includes a second support plate 661 fixedly disposed on the first sliding block 52, a second telescopic rod 662 fixedly disposed on the second support plate 661, a second blocking arc block 663 fixedly disposed on the second telescopic rod 662, a third return spring 664 fixedly disposed between the second support plate 661 and the second blocking arc block 663, a third connecting rod 666 fixedly disposed on the second blocking arc block 663, a fourth connecting rod 667 hinged to the third connecting rod 666, a lifting plate 668 hinged to the fourth connecting rod 667 and slidably connected to the first sliding block 52, and a position control clamp plate 665 fixedly connected to the third pressing rod 61 and engaged with the two second blocking arc blocks 663; the lifting plate 668 can slide only in the vertical direction of the first sliding block 52; the lift plate 668 cooperates with the first detent arc 655; the method comprises the following specific steps: the third press rod 61 moves downwards to make the position control clamp plate 665 drive the first slide block 52 to move downwards, and when the third press rod 61 is pressed for the first time, the position control clamp plate 665 is positioned at the opposite side of the second clamping arc-shaped block 663, namely, the position control clamp plate 665 and the second clamping arc-shaped block 663 form an angle of one hundred eighty degrees, then the third press rod 61 can not make the position control clamp plate 665 and the second clamping arc-shaped block 663 matched with each other when the third press rod is reset, so that the first press suction plate 2 and the first press suction plate 2 are reset, the first slide block 52 only realizes the downward movement and is clamped at the position, when the second press suction plate 2 downwards, the position control clamp plate 665 is positioned at the position where the position control clamp plate can be matched with the second clamping arc-shaped block 663, then the position control clamp plate 665 moves downwards to the position above the second clamping arc-shaped block 663 to drive the two second clamping arc-shaped blocks 663 to move towards two sides, then the position control clamp plate can move to the position below the second clamping arc-shaped block 663, then the second blocking arc-shaped block 663 is reset under the action of the third reset spring 664, so as to block the position control clamping plate 665, then the shape of the position control clamping plate 665 is that the lower part is large, the upper part is small, namely, a top position block is arranged above the position control clamping plate 665, so that the original positions of the second blocking arc-shaped block 663 are mutually abutted, then the position control clamping plate 665 moves to the lower part, namely, the two second blocking arc-shaped blocks 663 are abutted on the top position block, so that the distance between the two second blocking arc-shaped blocks 663 is increased, therefore, the second blocking arc-shaped blocks 663 can move compared with the position control clamping plate 665 before the position control clamping plate comes down, namely, the second blocking arc-shaped blocks 663 drive the second telescopic rods to move, then the second blocking arc-shaped blocks 663 can drive the third connecting rod 667662 to move towards the directions of two sides, and then the third connecting rod 666 can drive the lifting plate 668 to move downwards through the fourth connecting rod 665, then, the lifting plate 668 abuts against the first blocking arc-shaped block 655, and then the lifting plate 668 is outwardly pushed out of the first blocking arc-shaped block 655 under the action of the arc surface of the first blocking arc-shaped block 655.
Specifically, the suction head 5 further comprises a fourth gear 53 fixedly arranged below the guide plate 62, a second rotating shaft 55 rotatably arranged on the connecting cavity 51, a fifth gear 54 fixedly connected to the second rotating shaft 55 and meshed with the fourth gear 53, and a fan blade 56 fixedly arranged below the second rotating shaft 55 and positioned in the connecting cavity 51; the degree of each rotation of the rotary reversing disc 63 is integral multiple of forty-five degrees; the suction heads 5 are provided with eight suction heads in total; the rotary reversing disc 63 controls the suction head 5 to rotate forty-five degrees each time when the position is changed; when the suction head 5 is cleaned, the degree of rotation controlled by the rotary reversing disc 63 is integral multiple of forty-five degrees; the method comprises the following specific steps: rotatory switching-over dish 63 can drive suction head 5 and rotate, and later fourth gear 53 position is fixed, and fifth gear 54 also can rotate on fourth gear 53, later can make flabellum 56 take place rotatoryly, and flabellum 56 can blow to suction head 5 inside, can make the inside better keeping dry of suction head 5, can not have the water droplet to influence the result of drawing to the efficiency of better assurance amplification.
Specifically, the lifting and rotating structure 4 comprises a second pressure lever 48 fixedly arranged below the pressing and sucking plate 2, a lifting and rotating ring 41 fixedly connected to the second pressure lever 48, a connecting ring 45 rotatably connected to the lifting and rotating ring 41, a third gear 43 fixedly connected to the third pressure lever 61, a rotating guide plate 44 fixedly connected to the lifting and rotating ring 41, a second gear 42 fixedly connected to the rotating guide plate 44 and meshed with the third gear 43, a second chute 46 arranged inside the lifting and rotating ring 41, and a second guide rod 47 fixedly connected to the straw core 22 and slidably connected to the second chute 46; the lifting rotating ring 41 is arranged inside the suction tube pen 1 in a sliding manner; the connecting ring 45 moves up and down along with the lifting rotating ring 41; the connecting ring 45 is connected with the suction tube pen 1 in a sliding way and cannot rotate; the third pressure lever 61 is rotatably connected to the connecting ring 45; the method comprises the following specific steps: pressing the pressing suction plate 2 downward will drive the second pressing rod 48 to move downward, then the second pressing rod 48 will drive the lifting rotating ring 41 to move downward, then the lifting rotating ring 41 will drive the connecting ring 45 to move downward, then the connecting ring 45 will drive the third pressing rod 61 to move downward, then the lifting rotating ring 41 will rotate under the action of the second chute 46 and the second guiding rod 47 when the lifting rotating ring 41 moves downward, then the lifting rotating ring 41 will drive the rotating guiding plate 44 to rotate, the rotating guiding plate 44 will drive the second gear 42 to rotate, then the connecting ring 45 will not rotate, therefore, the third pressing rod 61 does not revolve around the lifting rotating ring 41, so that the third pressing rod 61 is always in one position and does not change, and then the third gear 43 is a one-way gear, and the second gear 42 rotates to drive the third gear 43 to rotate, and then the third gear 43 drives the third pressing rod 61 to rotate.
Specifically, the baffle structure 3 comprises a chassis 31 fixedly arranged below the straw pen 1, a plurality of first avoiding holes 32 arranged on the chassis 31 and matched with the suction head 5, a plurality of dust-proof plates 33 arranged on the baffle structure 3 in a sliding manner and used for blocking the first avoiding holes 32, a first connecting rod 34 hinged to the dust-proof plates 33, a second connecting rod 35 hinged to the first connecting rod 34, a rotating disc 36 rotatably arranged below the chassis 31 and hinged to the second connecting rod 35, and a first rotating shaft 37 fixedly connected to the rotating disc 36 and rotatably connected to the chassis 31 and used for guiding the rotating disc 36; seven dust-proof plates 33 are provided; eight first avoiding holes 32 are formed; the first avoiding hole 32 positioned below the third pressure lever 61 is provided with a dustproof movable plate 38; the dust-proof movable plate 38 and the dust-proof plate 33 have the same positional relationship; the method comprises the following specific steps: when a plurality of dust-proof plates 33 need to be opened simultaneously, the power structure 7 is started, the first rotating shaft 37 is made to rotate, so that the rotating disc 36 is driven to rotate, then the rotating disc 36 drives the second connecting rod 35 and the first connecting rod 34 to move, so that the dust-proof plates 33 move towards the centripetal direction, then seven dust-proof plates 33 are not used for blocking the first avoiding holes 32, then the connection relation between the dust-proof movable plates 38 and the dust-proof plates 33 is the same, so that the dust-proof movable plates 38 also move towards the centripetal direction, so that the eight first avoiding holes 32 are not blocked, and at this time, the suction head 5 can move downwards completely to clean the dust-proof plates.
Specifically, the power structure 7 comprises a driving motor 71 fixedly connected to the straw inner core 22, a winding disc 72 fixedly connected to the driving motor 71, a baffle structure 3 of the power structure 7 connected to the driving motor 71, and a rope 74 wound on the winding disc 72 and connected with the chassis 31 and the fourth gear 53 through the connection; after all the suction heads 5 are used once, the driving motor 71 drives the winding disc 72 to rotate, then the driving motor 71 also drives the first rotating shaft 37 to rotate through the baffle structure 3 of the power structure 7, then the driving motor 71 drives the winding disc 72 to rotate, the rope 74 can be wound on the winding disc 72, so that the rope 74 is pulled, the fourth gear 53 is pulled to move downwards through the rope 74, then the fourth gear 53 is positioned above the connecting cavity 51, so that the downward movement of the fourth gear 53 can also drive the suction heads 5 to move downwards, so that a plurality of the suction heads 5 can simultaneously move downwards for a certain distance, all the suction heads 5 can reach the lower part of the baffle structure 3, when the suction heads 5 are cleaned, all the suction heads 5 can be cleaned, the cleaning efficiency is improved, the rotating area of the first rotating shaft 37 and the winding disc 72 is separated through the baffle structure 3 of the power structure 7, preferably, the two movements do not conflict, and the stability of the movement is improved.
Specifically, the dustproof movable plate 38 includes a third sliding groove 381 disposed below the dustproof movable plate 38, an extension spring 382 disposed in the third sliding groove 381, a fourth sliding groove 384 disposed on the chassis 31, a first sliding rod 383 fixedly connected to the dustproof movable plate 38 and slidably connected to the fourth sliding groove 384, a second sliding rod 385 fixedly connected to the second connecting rod 35, slidably disposed in the third sliding groove 381, and connected to the extension spring 382, a through hole 386 disposed on the chassis 31 and communicated with the fourth sliding groove 384, a telescopic tube 387 fixedly disposed above the through hole 386, and a multi-section telescopic rod 388 fixedly disposed below the first sliding rod 52 and matched with the telescopic tube 387; the dust-proof plate 33 and the dust-proof movable plate 38 have similar structures; a first sliding rod 383 and a fourth sliding groove 384 matched with the first sliding rod 383 are arranged; the method comprises the following specific steps: the first sliding block 52 moves downwards to drive the multiple telescopic rods 388 to move downwards, then the multiple telescopic rods 388 reach the telescopic tube 387, then the multiple telescopic rods 388 stretch and contract, so that the air in the telescopic tube 387 is squeezed into the fourth sliding groove 384, then the air in the fourth sliding groove 384 pushes the first sliding rod 383 to move towards the centripetal direction, then the first sliding rod 383 drives the dust-proof movable plate 38 to move towards the centripetal direction, so that the dust-proof movable plate 38 opens the first avoiding hole 32, so that the suction head 5 moves to the lower part of the chassis 31, then the telescopic tube 387 is longer in length, then the multiple telescopic rods 388 can stretch and contract longer, so that after the first sliding block 52 moves downwards for a little, the multiple telescopic rods 388 compress the air in the telescopic tube 387 greatly, so that enough air pressure in the fourth sliding groove 384 can push the first sliding rod 383 to move, the rear multiple telescopic rods 388 can also be shortened to protect the first sliding rod 383, so that only one suction head 5 can be used at ordinary times.
Specifically, the connection hose 64 includes a first connection cabin 641 connected to the straw core 22; the first connection bin 641 is communicated with the straw inner core 22; the straw core 22 is not described in the prior art.
It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (8)

1. An amplification method for immunochromatographic monitoring signals, characterized in that: the method comprises the following steps:
A. performing accounting extraction on the solvent by using a solution suction device; the solution suction device comprises a suction tube pen (1), a pressing suction plate (2) arranged above the suction tube pen (1), a baffle plate structure (3) arranged below the suction tube pen (1), a first pressure rod (21) fixedly arranged below the pressing suction plate (2), a suction tube inner core (22) fixedly arranged below the first pressure rod (21) and positioned inside the suction tube pen (1), a lifting and rotating structure (4) connected with the pressing suction plate (2), a control structure (6) connected with the lifting and rotating structure (4), a suction head (5) connected with the control structure (6) and used for extraction, and a power structure (7) arranged below the suction tube inner core (22) and connected with the baffle plate structure (3);
B. the user holds the pipette pen (1) by hand, puts the thumb above the pressing suction plate (2), then presses the pressing suction plate (2) downwards, the pressing suction plate (2) moves downwards, at the moment, the pressing suction plate (2) is not loosened, in the downward movement of the pressing suction plate (2), the lifting rotating structure (4) and the baffle structure (3) are driven to move, then the baffle structure (3) can block all the suction heads (5) at first, the suction heads (5) are protected, the baffle structure (3) can be opened by pressing the pressing suction plate (2) downwards, one suction head (5) moves downwards, so that the suction head (5) can come out of the baffle structure (3), then the position of the pipette pen (1) is moved, the suction head (5) reaches a reagent box and is placed in the reagent box, then the pressing suction plate (2) is loosened, and the reagent can be extracted, then the pipette pen (1) is moved to a position where the reagent needs to be discharged outwards, and the suction plate (2) is pressed again, so that the solvent in the suction head (5) is extruded outwards;
C. the pressing suction plate (2) drives the suction head (5) to move downwards through the lifting and rotating structure (4) and the control structure (6), and after the pressing suction plate (2) finishes extruding the solvent out of the suction head (5), the lifting and rotating structure (4) and the control structure (6) can drive the suction head (5) to reset, so that the suction head (5) returns to the position above the baffle structure (3) again for protection; the control structure (6) comprises a third pressure rod (61) connected with the lifting rotating structure (4), a guide plate (62) fixedly connected with the straw pen (1), a rotating reversing disc (63) rotatably arranged on the guide plate (62), a first sliding chute (631) arranged on the rotating reversing disc (63), a guide assembly (65) connected with the first sliding chute (631), a first clamping assembly (66) and a second clamping assembly (67) connected with the guide assembly (65), a rotating motor (68) fixedly arranged above the rotating reversing disc (63) and fixedly connected with the straw inner core (22), and a connecting hose (64) connected with the straw inner core (22) and communicated with the straw inner core (22); the suction head (5) comprises a first sliding block (52) connected to the guide assembly (65) and matched with the third pressure lever (61), and a connecting cavity (51) fixedly connected to the first sliding block (52); the suction head (5) is fixedly connected with the connecting cavity (51); the first sliding block (52) is communicated with the connecting hose (64); the connecting cavity (51) is communicated with the first sliding block (52); the method comprises the following steps: the pressing suction plate (2) moves downwards, the third pressing rod (61) is driven to move downwards through the lifting rotating structure (4), then the third pressing rod (61) moves downwards for the first time, the first sliding block (52) is pressed downwards to move downwards, the first sliding block (52) moves under the guide of the guide assembly (65), then the first sliding block (52) drives the suction head (5) to move downwards through the connecting cavity (51), then the pressing suction plate (2) is pressed, air in the suction pipe inner core (22) is reduced, after the pressing suction plate (2) is released, the pressing suction plate (2) moves upwards, namely reagent is sucked into the suction head (5) through the suction pipe inner core (22), the connecting hose (64) and the first sliding block (52), then the pressing suction plate (2) is pressed downwards again to extrude the reagent in the suction head (5) outwards, namely, at this time, the pressing suction plate (2) drives the third pressing rod (61) to move downwards once, then move upwards once, and then move downwards once again, at this time, the third pressing rod (61) can move under the action of the lifting rotating structure (4), namely, the third pressing rod (61) can be matched with the first clamping component (66), so that the pressing suction plate (2) is pressed downwards for the first time, only the suction head (5) is driven to move downwards, the second pressing is performed downwards, in order to extrude the reagent in the suction head (5) outwards, and the third pressing rod (61) can be matched with the first clamping component (66), then the pressing suction plate (2) is released, the pressing suction plate (2) can move upwards, at this time, the pressing suction plate (2) can drive the third pressing rod (61) to move upwards through the lifting rotating structure (4), namely, the third pressing rod (61) can drive the suction head (5) to move upwards through the first clamping component (66), therefore, the sucker (5) can be reset upwards to the position above the baffle plate structure (3) after each use is finished;
D. the rotary reversing disc (63) drives the plurality of suction heads (5) to rotate, so that the suction heads (5) can be replaced, and the unused suction heads (5) can be replaced and matched with the lifting rotating structure (4) and the control structure (6);
E. repeating the steps A-D;
F. putting the extracted reagent into an RPA constant-temperature amplification instrument for amplification;
G. when all the suction heads (5) are used, the power structure (7) is started, the power structure (7) can drive the baffle structure (3) to move, all the suction heads (5) move downwards, all the suction heads (5) suck cleaning liquid and extrude the cleaning liquid at the same time, and the suction heads (5) are cleaned.
2. An amplification method for immunochromatographic monitoring signal according to claim 1, characterized in that: the guide assembly (65) comprises a first supporting plate (651) fixedly connected to the rotary reversing disc (63), a first guide rod (652) fixedly connected to the first supporting plate (651), a first compression spring (653) arranged below the first sliding block (52) and above the first supporting plate (651) and used for rapidly resetting the first sliding block (52), a clamping groove (654) arranged on the first sliding block (52), and a first clamping arc-shaped block (655) matched with the clamping groove (654) and used for clamping the first sliding block (52); the second clamping assembly (67) comprises a third supporting plate (675) fixedly arranged on the first supporting plate (651), a threaded rod (673) rotatably connected to the third supporting plate (675) and the rotary reversing disc (63), a first gear (672) fixedly connected to the threaded rod (673), a rack (671) fixedly connected to the first sliding block (52) and matched with the first gear (672), a nut (674) in threaded connection with the threaded rod (673), a guide block (676) fixedly connected to the nut (674), a first telescopic rod (678) fixedly connected to the guide block (676) and the first clamping arc-shaped block (655), and a guide assembly (65) power structure (7) arranged between the first clamping arc-shaped block (655) and the guide block (676) and used for resetting the first clamping arc-shaped block (655); the method comprises the following specific steps: the first sliding block (52) moves downwards to drive the rack (671) to move downwards, then the first sliding block (52) descends to a certain height to drive the rack (671) to be meshed with the first gear (672), then the first sliding block (52) continues to move downwards, so that the rack (671) drives the first gear (672) to rotate, then the first gear (672) drives the threaded rod (673) to rotate, so that the threaded rod (673) rotates to drive the nut (674) to move, so that the nut (674) is close to the first sliding block (52) to move, then the nut (674) drives the guide block (676) to move, namely the distance between the guide block (676) and the first clamping arc-shaped block (655) is reduced, then the clamping groove (654) and the first clamping arc-shaped block (655) are in the same horizontal position when the first sliding block (52) moves to the lowest position, the guide member (65) can be inserted into the locking groove (654) to fix the locking position of the locking groove (654), that is, the position of the first slide block (52), so that the first slide block (52) cannot be returned to the upward movement by the first compression spring (653).
3. An amplification method for immunochromatographic monitoring signal according to claim 2, characterized in that: the first clamping assembly (66) comprises a second supporting plate (661) fixedly arranged on the first sliding block (52), a second telescopic rod (662) fixedly arranged on the second supporting plate (661), a second clamping arc-shaped block (663) fixedly arranged on the second telescopic rod (662), a third return spring (664) fixedly arranged between the second supporting plate (661) and the second clamping arc-shaped block (663), a third connecting rod (666) fixedly arranged on the second clamping arc-shaped block (663), a fourth connecting rod (667) hinged to the third connecting rod (666), a lifting plate (668) hinged to the fourth connecting rod (667) and slidably connected to the first sliding block (52), and a position control clamping plate (665) fixedly connected to the third pressure rod (61) and matched with the two second clamping arc-shaped blocks (663); the lifting plate (668) can only slide in the vertical direction of the first sliding block (52); the lifting plate (668) is matched with the first clamping arc-shaped block (655); the method comprises the following specific steps: the third pressure lever (61) moves downwards, the position control clamping plate (665) can drive the first sliding block (52) to move downwards, and when the third pressure lever is pressed for the first time, the position control clamping plate (665) is located on the opposite surface of the second clamping arc-shaped block (663), namely the position control clamping plate (665) and the second clamping arc-shaped block (663) are at an angle of one hundred eighty degrees, then the third pressure lever (61) can not enable the position control clamping plate (665) to be matched with the second clamping arc-shaped block (663) when being reset, so that the suction plate (2) is pressed for the first time and the suction plate (2) is pressed for the first time to reset, the first pressure plate (52) only realizes downward movement and is clamped at the position, then when the suction plate (2) is pressed downwards for the second time, the position control clamping plate (665) is located at a position where the position control clamping plate can be matched with the second clamping arc-shaped block (663), and then the position control clamping plate (665) moves downwards to the second clamping arc-shaped block (663) and can drive the second clamping arc-shaped block (663) to move towards two sides After the movement, the position control clamping plate (665) moves to the position below the second clamping arc-shaped block (663), then the second clamping arc-shaped block (663) resets under the action of the third return spring (664) so as to clamp the position control clamping plate (665), then the shape of the position control clamping plate (665) is that the lower part is large and the upper part is small, namely a top position block is arranged above the position control clamping plate (665), so that two original positions of the second clamping arc-shaped block (663) are mutually abutted together, after the position control clamping plate (665) moves to the lower part, two second clamping arc-shaped blocks (663) are abutted against the top position block, so that the distance between the two second clamping arc-shaped blocks (663) is increased, so that the second clamping arc-shaped blocks (663) move before the position control clamping plate (665), namely the second clamping arc-shaped blocks (663) drive the second telescopic rod (662) to move, afterwards, the second blocking arc-shaped block (663) can also drive the third connecting rod (666) to move towards the directions of two sides, then the third connecting rod (666) can drive the lifting plate (668) to move downwards through the fourth connecting rod (667), then the lifting plate (668) can be enabled to prop against the first blocking arc-shaped block (655), and then the lifting plate (668) can be enabled to push out the first blocking arc-shaped block (655) outwards under the action of the cambered surface of the first blocking arc-shaped block (655).
4. An amplification method for immunochromatographic monitoring signal according to claim 1, characterized in that: the suction head (5) further comprises a fourth gear (53) fixedly arranged below the guide plate (62), a second rotating shaft (55) rotatably arranged on the connecting cavity (51), a fifth gear (54) fixedly connected to the second rotating shaft (55) and meshed with the fourth gear (53), and a fan blade (56) fixedly arranged below the second rotating shaft (55) and positioned in the connecting cavity (51); the degree of each rotation of the rotary reversing disc (63) is integral multiple of forty-five degrees; the suction heads (5) are provided with eight suction heads in total; the rotary reversing disc (63) controls the suction head (5) to rotate by forty-five degrees each time when the suction head is replaced; when the suction head (5) is cleaned, the rotating reversing disc (63) controls the rotating degree to be integral multiple of forty-five degrees; the method comprises the following specific steps: rotatory switching-over dish (63) can drive suction head (5) and rotate, and later fourth gear (53) position is fixed, and is that fifth gear (54) can rotate on fourth gear (53), later can make flabellum (56) take place rotatoryly, and flabellum (56) can blow to suction head (5) inside, can make suction head (5) inside better keep dry, can not have the water droplet to influence the result of drawing.
5. An amplification method for immunochromatographic monitoring signal according to claim 1, characterized in that: the lifting and rotating structure (4) comprises a second pressure rod (48) fixedly arranged below the pressing and sucking plate (2), a lifting and rotating ring (41) fixedly connected to the second pressure rod (48), a connecting ring (45) rotatably connected to the lifting and rotating ring (41), a third gear (43) fixedly connected to the third pressure rod (61), a rotating guide plate (44) fixedly connected to the lifting and rotating ring (41), a second gear (42) fixedly connected to the rotating guide plate (44) and meshed with the third gear (43), a second sliding groove (46) arranged in the lifting and rotating ring (41), and a second guide rod (47) fixedly connected to the straw inner core (22) and slidably connected to the second sliding groove (46); the lifting rotating ring (41) is arranged in the suction tube pen (1) in a sliding manner; the connecting ring (45) moves up and down along with the lifting rotating ring (41); the connecting ring (45) is connected with the suction tube pen (1) in a sliding way and cannot rotate; the third pressure rod (61) is rotatably connected to the connecting ring (45); the method comprises the following specific steps: the pressing suction plate (2) is pressed downwards, the second pressure rod (48) is driven to move downwards, then the second pressure rod (48) drives the lifting rotating ring (41) to move downwards, then the lifting rotating ring (41) drives the connecting ring (45) to move downwards, then the connecting ring (45) enables the third pressure rod (61) to move downwards, then the lifting rotating ring (41) can rotate the lifting rotating ring (41) under the action of the second sliding groove (46) and the second guide rod (47) when moving downwards, then the lifting rotating ring (41) drives the rotating guide plate (44) to rotate, the rotating guide plate (44) drives the second gear (42) to rotate, then the connecting ring (45) does not rotate, so that the third pressure rod (61) does not revolve around the lifting rotating ring (41), so that the third pressure rod (61) is always in one position and cannot change, and then the third gear (43) is a one-way gear, the second gear (42) rotates to drive the third gear (43) to rotate, and then the third gear (43) drives the third pressure rod (61) to rotate.
6. An amplification method for immunochromatographic monitoring signal according to claim 1, characterized in that: the baffle structure (3) comprises a chassis (31) fixedly arranged below the straw pen (1), a plurality of first avoidance holes (32) which are arranged on the chassis (31) and matched with the suction head (5), a plurality of dust-proof plates (33) which are arranged on the baffle structure (3) in a sliding mode and used for blocking the first avoidance holes (32), a first connecting rod (34) hinged to the dust-proof plates (33), a second connecting rod (35) hinged to the first connecting rod (34), a rotating disk (36) rotatably arranged below the chassis (31) and hinged to the second connecting rod (35), and a first rotating shaft (37) fixedly connected to the rotating disk (36) and rotatably connected to the chassis (31) and used for guiding the rotating disk (36); seven dust-proof plates (33) are arranged; eight first avoiding holes (32) are formed; a dustproof movable plate (38) is arranged at the first position avoiding hole (32) below the third pressure rod (61); the dust-proof movable plate (38) and the dust-proof plate (33) have the same position relation and connection relation; the method comprises the following specific steps: when a plurality of dust-proof plates (33) are required to be opened simultaneously, the power structure (7) is started, the first rotating shaft (37) is enabled to rotate, the rotating disc (36) is driven to rotate, then the rotating disc (36) drives the second connecting rod (35) and the first connecting rod (34) to move, so that the dust-proof plates (33) move towards the centripetal direction, then seven dust-proof plates (33) do not block the first avoiding hole (32), then the connection relation between the dust-proof plates (38) and the dust-proof plates (33) is the same, so that the dust-proof plates (38) can also move towards the centripetal direction, the eight first avoiding holes (32) are not blocked, and the suction head (5) can move downwards to clean the dust-proof plates.
7. The method of claim 6, wherein the step of amplifying the immunochromatographic monitoring signal comprises: the power structure (7) comprises a driving motor (71) fixedly connected to the straw inner core (22), a winding disc (72) fixedly connected to the driving motor (71), a baffle structure (3) connected to the power structure (7) of the driving motor (71), and a rope (74) wound on the winding disc (72) and penetrating through the chassis (31) and connected with the fourth gear (53); when all the suction heads (5) are used for one time, the driving motor (71) can drive the winding disc (72) to rotate, then the driving motor (71) can drive the first rotating shaft (37) to rotate through the baffle structure (3) of the power structure (7), then the driving motor (71) drives the winding disc (72) to rotate, and the rope (74) can be wound on the winding disc (72), thereby pulling the rope (74), and the fourth gear (53) is pulled to move downwards by the rope (74), and then the fourth gear (53) is positioned above the connecting cavity (51), so that the fourth gear (53) moves downwards and drives the suction head (5) to move downwards, so that a plurality of suction heads (5) move downwards at the same time for a certain distance, so that all suction heads (5) reach below the baffle structure (3), and then the suction heads (5) are cleaned.
8. An amplification method for immunochromatographic monitoring signal according to claim 7, wherein: the dustproof movable plate (38) comprises a third sliding groove (381) arranged below the dustproof movable plate (38), an extension spring (382) arranged in the third sliding groove (381), a fourth sliding groove (384) arranged on the chassis (31), a first sliding rod (383) fixedly connected to the dustproof movable plate (38) and slidably connected to the fourth sliding groove (384), a second sliding rod (385) fixedly connected to the second connecting rod (35), slidably arranged in the third sliding groove (381) and connected to the extension spring (382), a through hole (386) arranged on the chassis (31) and communicated with the fourth sliding groove (384), a telescopic pipe (387) fixedly arranged above the through hole (386), and a plurality of sections (388) fixedly arranged below the first telescopic pipe (52) and matched with the telescopic pipe (387); the dust-proof plate (33) and the dust-proof movable plate (38) have similar structures; both are provided with a first sliding rod (383) and a fourth sliding groove (384) matched with the first sliding rod; the method comprises the following specific steps: the first sliding block (52) moves downwards to drive the multiple sections of telescopic rods (388) to move downwards, then the multiple sections of telescopic rods (388) reach the telescopic pipe (387), then the multiple sections of telescopic rods (388) stretch and retract, so that air in the telescopic pipe (387) can be squeezed into the fourth sliding groove (384), then the air in the fourth sliding groove (384) can push the first sliding rod (383) to move towards the centripetal direction, then the first sliding rod (383) drives the dustproof movable plate (38) to move towards the centripetal direction, so that the dustproof movable plate (38) opens the first clearance hole (32), so that the suction head (5) can move to the lower part of the chassis (31), then the length of the telescopic pipe (387) is longer, then the telescopic lengths of the multiple sections of telescopic rods (388) are also longer, and then the first sliding block (52) can move downwards a little, the multi-section telescopic rod (388) can compress air in the telescopic pipe (387) greatly, so that the air pressure in the fourth sliding groove (384) is enough to push the first sliding rod (383) to move, the multi-section telescopic rod (388) can be shortened to protect the first sliding rod (383), and therefore the purpose that only one suction head (5) is used at ordinary times is achieved.
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