CN114190578A - Tobacco tar with tranquilizing effect and preparation method thereof - Google Patents

Tobacco tar with tranquilizing effect and preparation method thereof Download PDF

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Publication number
CN114190578A
CN114190578A CN202111466806.6A CN202111466806A CN114190578A CN 114190578 A CN114190578 A CN 114190578A CN 202111466806 A CN202111466806 A CN 202111466806A CN 114190578 A CN114190578 A CN 114190578A
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China
Prior art keywords
tobacco tar
caffeine
parts
tranquilizing effect
additive
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Pending
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CN202111466806.6A
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Chinese (zh)
Inventor
石宏宇
洪源
张成龙
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Tianjin Port Free Trade Zone Youweiwu Technology Co ltd
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Tianjin Port Free Trade Zone Youweiwu Technology Co ltd
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Priority to CN202111466806.6A priority Critical patent/CN114190578A/en
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    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10Chemical features of tobacco products or tobacco substitutes
    • A24B15/16Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18Treatment of tobacco products or tobacco substitutes
    • A24B15/28Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/285Treatment of tobacco products or tobacco substitutes by chemical substances characterised by structural features, e.g. particle shape or size
    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18Treatment of tobacco products or tobacco substitutes
    • A24B15/28Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • AHUMAN NECESSITIES
    • A24TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24BMANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18Treatment of tobacco products or tobacco substitutes
    • A24B15/28Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/302Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides tobacco tar with tranquilizing and allaying excitement functions and a preparation method thereof, which relate to the field of electronic cigarettes and comprise the following components: the liquid comprises a base liquid and an additive, wherein glycerol and/or propylene glycol are mixed to serve as the base liquid, and the additive at least comprises Bugenfuran and caffeine; the addition amount of the Buge furan is 0.1-2% by mass percent; the addition amount of the caffeine is 0.1-5% by mass percentage. The tobacco tar provided by the invention has comfortable taste and good safety, can be used for replacing nicotine tobacco tar, can relieve nicotine addiction, has the functions of tranquilizing, soothing nerves, resisting anxiety and the like, and is simple in preparation method, easy to operate and suitable for industrial production.

Description

Tobacco tar with tranquilizing effect and preparation method thereof
Technical Field
The invention relates to the field of electronic cigarettes, in particular to tobacco tar with a tranquilizing effect and a preparation method thereof.
Background
The development direction of the tobacco tar of the electronic cigarette at present is as follows: the method simulates the real cigarette taste, simulates various fruity tastes, improves the safety, reduces the production cost and the like. Few research teams are concerned about the health care and medicinal value of e-cigarettes. At present, no published data discloses a technical scheme for performing anti-anxiety physiotherapy by using an electronic cigarette.
In carrying out the present invention, the applicant has found that: aquilaria sinensis is a traditional rare traditional Chinese medicine, is a wood core which is infected by fungi and contains precipitation resin of Aquilaria (Aquilaria) plants in Thymelaeaceae (Thymelaeaceae), and is listed as the top grade in Shen nong Ben Cao Jing. The compendium of materia Medica records: the lignum Aquilariae Resinatum has effects of refreshing mind, invigorating qi, and coordinating mind. Chemical composition analysis of agilawood has been reported, and mainly focuses on the research of agilawood essential oil. Six classes of compounds are reported by domestic and foreign chemists in turn, such as: benzyl acetone, hydrogenated cinnamic acid, linalool, linalol spiro ring, and agarofuran.
The literature reports that the agarofuran compound and the derivative thereof have anxiolytic effect and mild central nervous inhibition effect. When the number of the alkyl carbon at the 4-position is 4-6, the anxiolytic effect and the central sedative and hypnotic effect are obvious (Vol.13, No.3, P125, Chinese journal of medicinal chemistry), and compared with the activity of a plurality of derivatives in the central nervous system, the bullofuran has the strongest anxiolytic and sedative effects. The Bugrefuran also has good prevention and treatment effects on drug addiction (application of CN111939149A Bugrefuran in preparing drugs for preventing and/or treating amphetamine drug addiction-related diseases).
But no technical scheme for applying the bulgafuran to the electronic cigarette tobacco tar exists at present. The technical difficulty is as follows: the BuGe furan is unstable at room temperature, 6% of impurities are generated in an accelerated experiment (30 ℃ and 60% RH) for 3 months, namely, the tobacco tar added with the BuGe furan is not easy to store and transport and is not convenient to popularize, and in addition, the BuGe furan is unstable after being dissolved in an organic solvent and is not easy to be delivered into a human body in an atomization mode.
Therefore, how to improve the stability of the bulgur so that the bulgur can exert the antianxiety physical therapy value in the electronic cigarette tobacco tar is a technical problem to be solved urgently.
Disclosure of Invention
The invention aims to at least solve one of the technical problems in the prior art or the related technology, and provides tobacco tar with the effects of tranquilizing and allaying excitement and a preparation method thereof, which can improve the stability of bugol, improve the taste, have good safety, can replace nicotine tobacco tar for use, can relieve nicotine addiction, and has the functions of tranquilizing, allaying excitement, resisting anxiety and the like.
The invention is realized by the following technical scheme:
the invention discloses tobacco tar with tranquilizing and allaying excitement function, which comprises the following components: the base liquid comprises glycerol and/or propylene glycol, and is used as atomized liquid for carrying the additive into a respiratory system; the additive at least comprises brewage furan and caffeine; the addition amount of the Buge furan is 0.1-2% by mass percent; the addition amount of the caffeine is 0.1-5% by mass percentage.
In the technical scheme, the caffeine is a xanthine alkaloid compound with a chemical formula of C8H10N4O2The chemical structural formula is as follows:
Figure BDA0003391901030000021
bugrefuran is an agarofuran compound. The compound has obvious anxiolytic effect, low toxic and side effects and wide market prospect, and the chemical structural formula of the bulgafuran is as follows:
Figure BDA0003391901030000022
the Bugenfuran is oily liquid, has strong fat solubility, is insoluble in water, and can be dissolved in glycerol and 1, 2-propylene glycol. The invention adds the bugol into the tobacco tar to ensure that the tobacco tar has the functions of tranquilizing and allaying excitement and assisting sleep, and the stability of the bugol is obviously improved after the caffeine is added into the tobacco tar.
According to the above technical solution of the present invention, preferably, the additive further includes: the mass percentage of the borneol is less than or equal to 3 percent.
In the technical scheme, the borneol has auxiliary functions of seasoning, cooling and diminishing inflammation, and is beneficial to improving the taste of tobacco tar after entering the mouth.
According to the above technical solution of the present invention, preferably, the additive further includes: the mint is less than or equal to 2 percent in percentage by mass.
In the technical scheme, the mint has auxiliary functions of seasoning, cooling and diminishing inflammation, and is beneficial to improving the taste of the tobacco tar after entering the mouth.
According to the above technical solution of the present invention, preferably, the method further includes: a nicotine substitute capable of simulating a nicotine "throat-strike" sensation.
According to the above technical solution of the present invention, preferably, the method further includes: essence capable of simulating fruit taste or tobacco taste in an atomized state.
According to the above technical solution of the present invention, preferably, the content of caffeine is greater than the content of bregfuran.
According to the above technical solution of the present invention, preferably, the content of caffeine is less than the content of bregfuran.
According to the above technical solution of the present invention, preferably, when the borneol and the mint are added simultaneously, the content of the borneol is greater than that of the mint.
According to the above technical solution of the present invention, preferably, the base liquid specifically includes: 10 parts of glycerol and 10 parts of 1, 2-propylene glycol in parts by mass.
According to the above technical solution of the present invention, preferably, the additive specifically includes: 2 parts of brix, 2 parts of caffeine, 3 parts of borneol and 2 parts of mint in parts by mass.
The invention also discloses a preparation method of the tobacco tar with the tranquilizing effect, which comprises the following steps: preparing raw materials according to the component proportion of the tobacco tar with the tranquilizing effect disclosed by any one of the technical schemes; shaking the base solution uniformly; adding the bulgaricus, and uniformly stirring; adding the fine ground caffeine powder, stirring and dissolving.
The beneficial effects obtained by the invention at least comprise: the stability of the bulgafuran is obviously improved after the caffeine is added into the tobacco tar, and the mint and the borneol are added to achieve the effects of opening orifices, dissipating stagnated fire, reducing swelling, relieving pain and the like, increase the smoke feeling and the taste and also promote the stability of the bulgafuran.
Detailed Description
In order that the above objects, features and advantages of the present invention can be more clearly understood, the present invention will be described in further detail with reference to specific embodiments.
Example 1
One embodiment of the invention discloses tobacco tar with tranquilizing effect, which comprises the following components: 10g of glycerol, 10g of 1, 2-propylene glycol, 0.2g of bulgafuran, 0.2g of caffeine, 0.3g of borneol and 0.2g of mint.
The preparation method comprises the following steps: respectively weighing 10g of glycerol and 10g of 1, 2-propylene glycol, mixing uniformly, adding 0.2g of bugol, stirring uniformly, adding 0.2g of ground caffeine, 0.3g of borneol and 0.2g of mint, and stirring for dissolving to obtain the final product.
In the embodiment, the added mint component can disperse wind and heat, clear head and eyes, relieve sore throat, and has an excitation effect after the mint enters a human body, can stimulate central nerves and indirectly conduct to peripheral nerves, dilate respiratory capillary vessels, and enhance the absorption of the human body to the buge furan.
Example 2
In another embodiment of the present invention, a tobacco tar with tranquilizing effect is disclosed, comprising: 10g of glycerol, 5g of 1, 2-propylene glycol, 0.3g of bulgafuran and 0.75g of caffeine.
The preparation method comprises the following steps: respectively weighing 10g of glycerol and 5g of 1, 2-propylene glycol, uniformly mixing, adding 0.3g of bugol, uniformly stirring, adding 0.75g of ground caffeine, and stirring for dissolving to obtain the product.
Example 3
In another embodiment of the present invention, a tobacco tar with tranquilizing effect is disclosed, comprising: 10g of glycerol, 0.01g of bulgafuran, 0.1g of caffeine, 0.3g of borneol and 0.2g of mint.
The preparation method comprises the following steps: weighing 10g of glycerol, adding 0.01g of bulgafuran, stirring uniformly, adding 0.2g of ground caffeine, 0.3g of borneol and 0.2g of mint, and stirring for dissolving to obtain the finished product.
Comparative example 1:
comparative example 1 was prepared according to the formulation of example 1, except that caffeine, borneol and peppermint were removed. Respectively weighing 10g of glycerol and 1, 2-propylene glycol, uniformly mixing, adding 0.2g of bulgur, and uniformly stirring to obtain the finished product.
Comparative example 2:
comparative example 2 was prepared according to the formulation of example 1, except that borneol and peppermint were removed. Respectively weighing 10g of glycerol and 1, 2-propylene glycol, uniformly mixing, adding 0.2g of bugol, uniformly stirring, adding 0.2g of ground caffeine, and stirring for dissolving to obtain the product.
Comparative experiment:
the samples of example 1, comparative example 1 and comparative example 2 are respectively added into a smoke bomb, the smoke bomb is placed for 3 months under the condition of accelerated experiment (30 ℃ and 60% RH), samples are respectively taken for 1 month, 2 months and 3 months to detect the impurity content, and the stability of the tobacco tar is examined, and the results are as follows:
Figure BDA0003391901030000051
in conclusion, the stability of the bugol is improved by adding the caffeine into the tobacco tar, and the mint and the borneol are added to achieve the effects of dredging orifices, dispelling stagnated fire, relieving swelling, relieving pain and the like, increase the smoke feeling and the taste and promote the stability of the bugol. Compared with the traditional tobacco tar, the tobacco tar with the effects of tranquilizing and allaying excitement disclosed by the invention has the advantages that the taste is improved, the safety is good, the tobacco tar can be used instead of nicotine tobacco tar, the addiction of nicotine can be relieved, and the functions of tranquilizing, allaying excitement and the like are realized.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (9)

1. A tobacco tar with tranquilizing effect comprises base fluid and additive, and is characterized in that,
the base liquid comprises glycerol and/or propylene glycol, and is used as atomized liquid for carrying the additive into a respiratory system;
the additive at least comprises brewage furan and caffeine;
the addition amount of the Buge furan is 0.1-2% by mass percent;
the addition amount of the caffeine is 0.1-5% by mass percent.
2. The tobacco tar with tranquilizing effect according to claim 1, wherein the additive further comprises: the mass percentage of the borneol is less than or equal to 3 percent.
3. The tobacco tar with tranquilizing effect according to claim 1 or 2, wherein the additive further comprises: the mint is less than or equal to 2 percent in percentage by mass.
4. The tobacco tar with tranquilizing effect according to claim 1, wherein the content of caffeine is greater than the content of bregfuran.
5. The tobacco tar with tranquilizing effect according to claim 1, wherein the content of caffeine is less than the content of bregfuran.
6. The tobacco tar with tranquilizing effect according to claim 3, wherein when Borneolum Syntheticum and herba Menthae are added simultaneously, the content of Borneolum Syntheticum is greater than that of herba Menthae.
7. The tobacco tar with tranquilizing effect according to claim 1, wherein the base fluid specifically comprises: 10 parts of glycerol and 10 parts of 1, 2-propylene glycol in parts by mass.
8. The tobacco tar with tranquilizing effect according to claim 1, wherein the additive specifically comprises: 2 parts of brix, 2 parts of caffeine, 3 parts of borneol and 2 parts of mint in parts by mass.
9. A preparation method of tobacco tar with tranquilizing effect is characterized by comprising the following steps:
preparing raw materials according to the component proportion of the tobacco tar with the tranquilizing effect of any one of claims 1 to 8;
shaking the base solution uniformly;
adding the bulgaricus, and uniformly stirring;
adding the fine ground caffeine powder, stirring and dissolving.
CN202111466806.6A 2021-12-03 2021-12-03 Tobacco tar with tranquilizing effect and preparation method thereof Pending CN114190578A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114869875A (en) * 2022-05-12 2022-08-09 天津港保税区有维生物科技有限公司 Application of Bugenfuran in preparation of smoking cessation product

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CN106108113A (en) * 2016-06-28 2016-11-16 熊轶 A kind of electronic cigarette tobacco tar with gum health effect and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114869875A (en) * 2022-05-12 2022-08-09 天津港保税区有维生物科技有限公司 Application of Bugenfuran in preparation of smoking cessation product

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