CN114174320A - 嵌合的人***瘤病毒18型l1蛋白 - Google Patents
嵌合的人***瘤病毒18型l1蛋白 Download PDFInfo
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- 201000005102 vulva cancer Diseases 0.000 description 1
- 238000003989 weak cation exchange chromatography Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
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Abstract
本发明公开了嵌合的人***瘤病毒18型L1蛋白和编码其的多核苷酸，还公开了HPV 18型病毒样颗粒和其制备方法。所述嵌合的人***瘤病毒18型L1蛋白包含衍生于HPV 18型L1蛋白的N端片段，所述N端片段保持HPV 18型L1蛋白的免疫原性；和衍生于第二型别***瘤病毒L1蛋白的C端片段，所述第二型别***状瘤病毒L1蛋白具有相较于其他型别的L1蛋白表达量和可溶性较好的特性；其中所述嵌合的HPV 18型L1蛋白具有HPV 18型L1蛋白的免疫原性。
Description
PCT国内申请，说明书已公开。
Claims (23)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019106562541 | 2019-07-19 | ||
| CN201910656254 | 2019-07-19 | ||
| PCT/CN2020/102606 WO2021013075A1 (zh) | 2019-07-19 | 2020-07-17 | 嵌合的人***瘤病毒18型l1蛋白 |
Publications (2)
| Publication Number | Publication Date |
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| CN114174320A true CN114174320A (zh) | 2022-03-11 |
| CN114174320B CN114174320B (zh) | 2024-05-24 |
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| CN202080051732.7A Active CN114174320B (zh) | 2019-07-19 | 2020-07-17 | 嵌合的人***瘤病毒18型l1蛋白 |
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| Country | Link |
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| CN (1) | CN114174320B (zh) |
| WO (1) | WO2021013075A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2024503452A (ja) * | 2021-01-14 | 2024-01-25 | 神州細胞工程有限公司 | ヒトパピローマウイルスウイルス様粒子ワクチンの安定な調製 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821087A (en) * | 1995-03-30 | 1998-10-13 | Merck & Co., Inc. | Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA |
| WO2001097840A1 (en) * | 2000-06-21 | 2001-12-27 | Medimmune, Inc. | Chimeric human papillomavirus (hpv) l1 molecules and uses therefor |
| CN106795518A (zh) * | 2014-06-19 | 2017-05-31 | 科罗拉多大学董事会，法人 | 人类***瘤病毒构建体 |
| WO2017092710A1 (zh) * | 2015-12-04 | 2017-06-08 | 厦门大学 | 一种人***瘤病毒58型l1蛋白的突变体 |
| WO2017157173A1 (zh) * | 2016-03-15 | 2017-09-21 | 中国医学科学院基础医学研究所 | 一种***瘤病毒嵌合蛋白及其用途 |
| CN107188967A (zh) * | 2016-03-15 | 2017-09-22 | 中国医学科学院基础医学研究所 | 一种***瘤病毒嵌合蛋白及其用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102747047B (zh) * | 2012-02-28 | 2016-03-23 | 厦门大学 | 人***瘤病毒型别杂合病毒样颗粒及其制备方法 |
-
2020
- 2020-07-17 WO PCT/CN2020/102606 patent/WO2021013075A1/zh active Application Filing
- 2020-07-17 CN CN202080051732.7A patent/CN114174320B/zh active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821087A (en) * | 1995-03-30 | 1998-10-13 | Merck & Co., Inc. | Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA |
| WO2001097840A1 (en) * | 2000-06-21 | 2001-12-27 | Medimmune, Inc. | Chimeric human papillomavirus (hpv) l1 molecules and uses therefor |
| US20040224305A1 (en) * | 2000-06-21 | 2004-11-11 | Wilson Susan D. | Chimeric human papillomavirus (HPV) L1 molecules and uses therefor |
| CN106795518A (zh) * | 2014-06-19 | 2017-05-31 | 科罗拉多大学董事会，法人 | 人类***瘤病毒构建体 |
| WO2017092710A1 (zh) * | 2015-12-04 | 2017-06-08 | 厦门大学 | 一种人***瘤病毒58型l1蛋白的突变体 |
| WO2017157173A1 (zh) * | 2016-03-15 | 2017-09-21 | 中国医学科学院基础医学研究所 | 一种***瘤病毒嵌合蛋白及其用途 |
| CN107188967A (zh) * | 2016-03-15 | 2017-09-22 | 中国医学科学院基础医学研究所 | 一种***瘤病毒嵌合蛋白及其用途 |
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| Publication number | Publication date |
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| WO2021013075A1 (zh) | 2021-01-28 |
| CN114174320B (zh) | 2024-05-24 |
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