CN114129466A - 一种新型美白牙贴 - Google Patents
一种新型美白牙贴 Download PDFInfo
- Publication number
- CN114129466A CN114129466A CN202111333026.4A CN202111333026A CN114129466A CN 114129466 A CN114129466 A CN 114129466A CN 202111333026 A CN202111333026 A CN 202111333026A CN 114129466 A CN114129466 A CN 114129466A
- Authority
- CN
- China
- Prior art keywords
- percent
- agent
- hydrogen peroxide
- novel whitening
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 44
- 239000000606 toothpaste Substances 0.000 title claims abstract description 22
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 21
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 61
- 239000004365 Protease Substances 0.000 claims abstract description 16
- 239000003381 stabilizer Substances 0.000 claims abstract description 14
- 239000003349 gelling agent Substances 0.000 claims abstract description 9
- 239000003906 humectant Substances 0.000 claims abstract description 9
- 239000002562 thickening agent Substances 0.000 claims abstract description 9
- 108091005804 Peptidases Proteins 0.000 claims abstract description 8
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract description 8
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 7
- 239000003765 sweetening agent Substances 0.000 claims abstract description 7
- 239000000043 antiallergic agent Substances 0.000 claims abstract description 6
- 239000008367 deionised water Substances 0.000 claims abstract description 5
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 19
- 238000001816 cooling Methods 0.000 claims description 10
- BAERPNBPLZWCES-UHFFFAOYSA-N (2-hydroxy-1-phosphonoethyl)phosphonic acid Chemical compound OCC(P(O)(O)=O)P(O)(O)=O BAERPNBPLZWCES-UHFFFAOYSA-N 0.000 claims description 8
- 108010004032 Bromelains Proteins 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 7
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 7
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
- 235000019835 bromelain Nutrition 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 235000019419 proteases Nutrition 0.000 claims description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 7
- 239000004475 Arginine Substances 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 230000003266 anti-allergic effect Effects 0.000 claims description 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 6
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical group [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000007373 indentation Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000002985 plastic film Substances 0.000 claims description 5
- 229920006255 plastic film Polymers 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000002699 waste material Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 108090000526 Papain Proteins 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- -1 includes back sheet Substances 0.000 claims description 3
- 238000010030 laminating Methods 0.000 claims description 3
- 235000019834 papain Nutrition 0.000 claims description 3
- 229940055729 papain Drugs 0.000 claims description 3
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 2
- 229930182830 galactose Natural products 0.000 claims description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 2
- 229940085605 saccharin sodium Drugs 0.000 claims description 2
- 229910001631 strontium chloride Inorganic materials 0.000 claims description 2
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims description 2
- 239000010409 thin film Substances 0.000 claims 1
- 201000002170 dentin sensitivity Diseases 0.000 abstract description 3
- 230000036347 tooth sensitivity Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 10
- 238000012360 testing method Methods 0.000 description 8
- WSELJKAMVUHMJP-PUZYILPLSA-N (2s,3r,4s,5r)-2,3-dichloro-2,3,4,5,6-pentahydroxyhexanoyl chloride Chemical compound OC[C@@H](O)[C@H](O)[C@@](O)(Cl)[C@](O)(Cl)C(Cl)=O WSELJKAMVUHMJP-PUZYILPLSA-N 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000006076 specific stabilizer Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000013077 scoring method Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cosmetics (AREA)
Abstract
本发明涉及一种新型美白牙贴,包括依次贴合的背衬层、凝胶层和薄膜层,所述凝胶层由以下组分按照重量百分比组成:增稠剂1%~15%、凝胶剂0.5%~5%、保湿剂20%~80%、抗敏剂0.1%~20%、甜味剂0.01%~0.5%、香精0.01%~0.5%、稳定剂0.001%~0.1%、去离子水20%~50%、过氧化氢1%~15%,蛋白酶0.5‑1%。本发明的过氧化氢型美白牙贴化学成分稳定,低过氧化氢含量降低了使用者的牙敏感风险性,但美白效果更加突出。
Description
技术领域
本发明属于牙齿美白技术领域,具体涉及了一种新型美白牙贴。
背景技术
人们对洁白牙齿的追求,使得牙齿美白技术在口腔临床诊疗中的地位日益趋升。牙齿美白是任何使牙齿颜色变白的过程,美白可以通过物理去除污渍或通过化学反应来淡化牙齿颜色来完成。
目前临床应用最广泛的漂白剂是过氧化氢(hydrogen peroxide,HP)和过氧化脲carbamide per-oxide,CP)。研究表明,35%过氧化氢比15%过氧化氢更有效,但高浓度会给患者带来更大的牙敏感风险性。此外,过氧化氢会氧化产品配方中的其他成分,降低了整体的稳定性。
因此,如何开发一种稳定性更高、成分更温和的美白牙贴,是提高牙贴美白技术的安全可靠性亟待解决的问题。
发明内容
为解决现有过氧化氢型美白牙贴化学成分不稳定、低过氧化氢含量导致美白效果不突出的问题,本发明提供了一种新型美白牙贴及其制备方法。
为实现上述目的,本发明提供如下技术方案:
一种新型美白牙贴,包括依次贴合的背衬层、凝胶层和薄膜层,所述凝胶层由以下组分按照重量百分比组成:增稠剂1%~15%、凝胶剂0.5%~5%、保湿剂20%~80%、抗敏剂0.1%~20%、甜味剂0.01%~0.5%、香精0.01%~0.5%、稳定剂0.001%~0.1%、去离子水20%~50%、过氧化氢1%~15%,蛋白酶0.5-1%。
优选地,所述增稠剂为羧甲基纤维素钠、卡波姆。
优选地,所述凝胶剂为聚丙烯酸钠。
优选地,所述保湿剂为甘油、聚乙二醇或丙二醇中的一种或两种。
优选地,所述抗敏剂为精氨酸、单氟磷酸钠或氯化锶中的一种或两种。
优选地,所述甜味剂为三聚半乳糖或糖精钠。
优选地,所述香精味薄荷香精
优选地,所述稳定剂为乙酸与羟基乙叉二膦酸的复配物,其中乙酸与羟基乙叉二膦酸的重量比为2:1。
优选地,所述蛋白酶为木瓜蛋白酶、菠萝蛋白酶中的一种或两种。
优选地,过氧化氢为5%~10%。
作为本发明的另一发明目的,本发明还提供了上述新型美白牙贴的制备方法,包括以下步骤:
(1)将增稠剂、凝胶剂、保湿剂混合均匀,加热至130~150℃至完全溶解,得到A液,冷却至60~70℃,备用;
(2)将甜味剂、香精溶解于无水乙醇中,得到B液,将B液添加到A液中,搅拌均匀,待降温至室温,再加入增白剂过氧化氢、抗敏剂和蛋白酶组成的混合液C液,得到混合凝胶。
(3)将稳定剂添加到混合凝胶中,并调节凝胶的pH在4.5-5.0之间。
(4)将混合凝胶涂布于背衬层并覆盖上塑料薄膜层,在通过分切、压痕、收废、切割、干燥工艺制备出抗敏美白牙贴。
与现有技术相比,本发明所取得如下有益技术效果:
(1)本发明以过氧化氢作为增白剂的前提下,大幅减少了过氧化氢的用量,避免了高含量过氧化氢给患者带来更大的牙敏感风险性;
(2)添加了抗敏成分来有效减缓过氧化氢对牙齿健康的刺激;
(3)并对各原料组分的添加比例进行了优化,通过加入蛋白酶,起到协同效应,确保过氧化氢在低含量的情况下仍满足所需的美白效果;
(4)通过设计特定的稳定剂复配物,并调整混合凝胶的pH值在一定范围内,使牙贴稳定性更佳,使用时与牙齿的贴合度更紧密,最大程度的发挥了产品的美白效果。
具体实施方式
下面将结合本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
一种新型美白牙贴,包括依次贴合的背衬层、凝胶层和薄膜层,所述凝胶层由以下组分按照重量百分比组成:羧甲基纤维素钠9%、聚丙烯酸钠2%、甘油25%、聚乙二醇10%、去离子水20%、过氧化氢12%、精氨酸5%、稳定剂0.01%、三氯半乳糖0.01%、薄荷香精0.3%、菠萝蛋白酶0.5%、无水乙醇补足100%;所述稳定剂为乙酸与羟基乙叉二膦酸的复配物,其中乙酸与羟基乙叉二膦酸的重量比为2:1。
新型美白牙贴制备方法如下:
(1)将羧甲基纤维素钠、聚丙烯酸钠、甘油、聚乙二醇混合均匀,加热至130℃至完全溶解,得到A液,冷却至60℃,备用。
(2)将三氯半乳糖、薄荷香精溶解于无水乙醇中,得到B液,将B液添加到A液中,搅拌均匀,待降温至室温,再加入过氧化氢、精氨酸和菠萝蛋白酶的混合液C液,得到混合凝胶。
(3)将稳定剂添加到混合凝胶中,调节凝胶的pH在4.6之间。
(4)将混合凝胶涂布于背衬层并覆盖上塑料薄膜层,在通过分切、压痕、收废、切割、干燥工艺制备出抗敏美白牙贴。
实施例2
本实施例提供一种抗敏美白牙贴,主要由以下质量百分比含量的组分组成:羧甲基纤维素钠5%、卡波姆20%、甘油30%、去离子水25%、过氧化氢6%、单氟磷酸钠5%、稳定剂0.01%、三氯半乳糖0.01%、薄荷香精0.3%、木瓜蛋白酶1%、无水乙醇补足100%;所述稳定剂为乙酸与羟基乙叉二膦酸的复配物,其中乙酸与羟基乙叉二膦酸的重量比为2:1。
新型美白牙贴制备方法如下:
(1)将羧甲基纤维素钠、聚丙烯酸钠、甘油、聚乙二醇混合均匀,加热至130℃至完全溶解,得到A液,冷却至60℃,备用。
(2)将三氯半乳糖、薄荷香精溶解于无水乙醇中,得到B液,将B液添加到A液中,搅拌均匀,待降温至室温,再加入过氧化氢、精氨酸和菠萝蛋白酶的混合液C液,得到混合凝胶。
(3)将稳定剂添加到混合凝胶中,调节凝胶的pH在4.5之间。
(4)将混合凝胶涂布于背衬层并覆盖上塑料薄膜层,在通过分切、压痕、收废、切割、干燥工艺制备出抗敏美白牙贴。
对比例1
本对比例不含稳定剂,其余配方与实施例2相同。
该新型美白牙贴制备方法如下:
(1)将羧甲基纤维素钠、聚丙烯酸钠、甘油、聚乙二醇混合均匀,加热至130℃至完全溶解,得到A液,冷却至60℃,备用。
(2)将三氯半乳糖、薄荷香精溶解于无水乙醇中,得到B液,将B液添加到A液中,搅拌均匀,待降温至室温,再加入过氧化氢、精氨酸和菠萝蛋白酶的混合液C液,得到混合凝胶。
(3)将混合凝胶涂布于背衬层并覆盖上塑料薄膜层,在通过分切、压痕、收废、切割、干燥工艺制备出抗敏美白牙贴。
对比例2
本对比例不加入菠萝蛋白酶,其余与对比例1相同。
试验例1过氧化氢的稳定性试验
将实施例1-2及对比例1-2中的凝胶组合物进行过氧化氢的定量方法滴定,然后于室温存储1、2、6个月,然后计算过氧化氢的含量变化,结果如表1所示。
试验样品 | 1个月 | 2个月 | 6个月 |
实施例1 | 11.8% | 11.6% | 11.55% |
实施例2 | 5.95% | 5.92% | 5.84% |
对比例1 | 5.7% | 5.3% | 5.0% |
对比例2 | 5.68% | 5.2% | 5.02% |
从表1可以看出,实施例1存放6个月后氧化氢含量的稳定性为96.25%,实施例2存放6个月后氧化氢含量的稳定性为97.33%,而没有加入本发明特定稳定剂的对比例1-2存放6个月后氧化氢含量的稳定性分别为83.33%和83.67%。
试验例2牙贴的美白效果测试
经体检指标全部正常的200名受试人分为四组,每组各50人,分别使用实施例1-2和对比例1-2的牙贴,每天2次,每次15min,受试者使用前进行色斑指数检测(基线),连续使用3个月(90天)后再进行色斑指数检测,比较使用前后受试者的色斑指数变化。
色斑指数计分法,具体计分规则如下:
0分—无色斑存在;
1分—有色斑,色斑大小不超过牙面的1/3,程度为轻度色斑(黄色或黄褐色);
2分—有色斑,色斑大小超过牙面1/3,不超过牙面2/3,程度为中度色斑(中等程度棕色);
3分—有色斑,色斑大小超过牙面的2/3,程度为重度色斑(深棕或黑色)。
检查牙位为下颂前牙的唇、舌面及上领前牙的唇面。每个牙面色斑指数计数分为该牙面的色斑面积计分和色斑程度计分的乘积。每个受试者的色斑指数计分为各牙面色斑指数计分的平均值,即:色斑指数=∑(面积计分程度计分)/总的检查牙面数。
色斑指数测定结果参见表2。
以上显示和描述了本发明的基本原理、主要特征和本发明的优点。本行业的技术人员应该了解,本发明不受上述实施例的限制,上述实施例和说明书中描述的仅为本发明的优选例,并不用来限制本发明,在不脱离本发明精神和范围的前提下,本发明还会有各种变化和改进,这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (10)
1.一种新型美白牙贴,包括依次贴合的背衬层、凝胶层和薄膜层,其特征在于,所述凝胶层由以下组分按照重量百分比组成:增稠剂1%~15%、凝胶剂0.5%~5%、保湿剂20%~80%、抗敏剂0.1%~20%、甜味剂0.01%~0.5%、香精0.01%~0.5%、稳定剂0.001%~0.1%、去离子水20%~50%、过氧化氢1%~15%,蛋白酶0.5-1%。
2.根据权利要求1所述的一种新型美白牙贴,其特征在于,所述增稠剂为羧甲基纤维素钠、卡波姆。
3.根据权利要求1所述的一种新型美白牙贴,其特征在于,所述凝胶剂为聚丙烯酸钠。
4.根据权利要求1所述的一种新型美白牙贴,其特征在于,所述保湿剂为甘油、聚乙二醇或丙二醇中的一种或两种。
5.根据权利要求1所述的一种新型美白牙贴,其特征在于,所述抗敏剂为精氨酸、单氟磷酸钠或氯化锶中的一种或两种。
6.根据权利要求1所述的一种新型美白牙贴,其特征在于,所述甜味剂为三聚半乳糖或糖精钠;所述香精味薄荷香精。
7.根据权利要求1所述的一种新型美白牙贴,其特征在于,所述稳定剂为乙酸与羟基乙叉二膦酸的复配物,其中乙酸与羟基乙叉二膦酸的重量比为2:1。
8.根据权利要求1所述的一种新型美白牙贴,其特征在于,所述蛋白酶为木瓜蛋白酶、菠萝蛋白酶中的一种或两种。
9.根据权利要求1所述的一种新型美白牙贴,其特征在于,过氧化氢为5%~10%。
10.权利要求1-9任一项所述的一种新型美白牙贴的制备方法,其特征在于,包括以下步骤:
(1)将增稠剂、凝胶剂、保湿剂混合均匀,加热至130~150℃至完全溶解,得到A液,冷却至60~70℃,备用;
(2)将甜味剂、香精溶解于无水乙醇中,得到B液,将B液添加到A液中,搅拌均匀,待降温至室温,再加入增白剂过氧化氢、抗敏剂和蛋白酶组成的混合液C液,得到混合凝胶。
(3)将稳定剂添加到混合凝胶中,并调节凝胶的pH在4.5-5.0之间。
(4)将混合凝胶涂布于背衬层并覆盖上塑料薄膜层,在通过分切、压痕、收废、切割、干燥工艺制备出抗敏美白牙贴。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111333026.4A CN114129466A (zh) | 2021-11-11 | 2021-11-11 | 一种新型美白牙贴 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111333026.4A CN114129466A (zh) | 2021-11-11 | 2021-11-11 | 一种新型美白牙贴 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114129466A true CN114129466A (zh) | 2022-03-04 |
Family
ID=80393627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202111333026.4A Pending CN114129466A (zh) | 2021-11-11 | 2021-11-11 | 一种新型美白牙贴 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114129466A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115778840A (zh) * | 2022-12-08 | 2023-03-14 | 广州欧诺洁个人护理用品有限公司 | 一种pap无残留美白牙贴制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1981025A (zh) * | 2004-07-09 | 2007-06-13 | 阿科玛股份有限公司 | 稳定化的增稠的包含过氧化氢的组合物 |
CN101829026A (zh) * | 2010-05-11 | 2010-09-15 | 李少君 | 清除牙齿色斑的组合物 |
CN102429829A (zh) * | 2011-12-10 | 2012-05-02 | 江西炫尼诗科技有限公司 | 牙科诊室用强效牙齿漂白凝胶 |
CN102961261A (zh) * | 2012-12-12 | 2013-03-13 | 广州安德健康科技有限公司 | 一种美白牙贴 |
US20140113253A1 (en) * | 2012-10-23 | 2014-04-24 | Oraceutical Llc | Method of simultaneously cleaning and whitening teeeth |
US20160106641A1 (en) * | 2014-10-20 | 2016-04-21 | Oraceutical Llc | Stable compositions for whitening teeth and methods of using same |
US20200121570A1 (en) * | 2018-10-22 | 2020-04-23 | Jasibo, Llc | Teeth whitening system, compositions and methods |
CN112043622A (zh) * | 2020-09-22 | 2020-12-08 | 上海绿瑞生物科技有限公司 | 一种含酶制剂和生物玻璃的修复美白牙膏及其制备方法 |
-
2021
- 2021-11-11 CN CN202111333026.4A patent/CN114129466A/zh active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1981025A (zh) * | 2004-07-09 | 2007-06-13 | 阿科玛股份有限公司 | 稳定化的增稠的包含过氧化氢的组合物 |
CN101829026A (zh) * | 2010-05-11 | 2010-09-15 | 李少君 | 清除牙齿色斑的组合物 |
CN102429829A (zh) * | 2011-12-10 | 2012-05-02 | 江西炫尼诗科技有限公司 | 牙科诊室用强效牙齿漂白凝胶 |
US20140113253A1 (en) * | 2012-10-23 | 2014-04-24 | Oraceutical Llc | Method of simultaneously cleaning and whitening teeeth |
CN102961261A (zh) * | 2012-12-12 | 2013-03-13 | 广州安德健康科技有限公司 | 一种美白牙贴 |
US20160106641A1 (en) * | 2014-10-20 | 2016-04-21 | Oraceutical Llc | Stable compositions for whitening teeth and methods of using same |
US20200121570A1 (en) * | 2018-10-22 | 2020-04-23 | Jasibo, Llc | Teeth whitening system, compositions and methods |
CN112043622A (zh) * | 2020-09-22 | 2020-12-08 | 上海绿瑞生物科技有限公司 | 一种含酶制剂和生物玻璃的修复美白牙膏及其制备方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115778840A (zh) * | 2022-12-08 | 2023-03-14 | 广州欧诺洁个人护理用品有限公司 | 一种pap无残留美白牙贴制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3560485A1 (en) | Transdermal compositions of ibuprofen and methods of use thereof | |
CN105232438A (zh) | 一种滋润修护面膜及其制备方法 | |
CN107998036A (zh) | 一种针对口腔综合问题的牙膏及其制造方法 | |
CN114129466A (zh) | 一种新型美白牙贴 | |
CN108030749B (zh) | 一种医用海藻牙膏 | |
CN105106081B (zh) | 一种用于口腔炎症的中草药牙膏及其制备方法 | |
CN101455654B (zh) | 精氨酸布洛芬凝胶剂及其制备方法 | |
CN114344181A (zh) | 一种舒缓抗皱精华水及其制备方法 | |
CN113648251A (zh) | 一种皮肤修护组合物及其制备方法 | |
CN109745241B (zh) | 一种茯苓面膜液及其制备方法 | |
CN115624650A (zh) | 一种医用海藻糖修复凝胶及其制备方法 | |
CN109700690B (zh) | 一种茯苓保湿乳液及其制备方法 | |
CN114404333A (zh) | 一种具有祛痘功效的洁面慕斯及其制备方法和应用 | |
CN111096934B (zh) | 一种抑制痤疮的凝胶 | |
CN113197831A (zh) | 一种含蜂蜜的修护唇膜及其制备方法 | |
CN113101243A (zh) | 口腔软组织细胞修复促进剂、口腔护理组合物及应用 | |
CN111228138A (zh) | 一种玻尿酸精华液及其制备方法 | |
CN109692142B (zh) | 一种茯苓洁面乳及其制备方法 | |
CN115364028B (zh) | 一种生物肽赋活修护面膜液及其制备方法 | |
CN113143841B (zh) | 含有金盏菊提取物的美白保湿凝胶面膜及其制备与应用 | |
CN113576942B (zh) | 一种抗糖牙膏及其制备方法 | |
CN115887271B (zh) | 一种含nmn的抗衰保湿水及其制备方法 | |
CN113712877B (zh) | 一种烟酰胺甘菊美肤面膜液及其制备方法 | |
JPWO2004004675A1 (ja) | 皮膚外用剤 | |
CN118415896A (zh) | 一种温和美白牙齿的组合物及其制备方法和牙贴 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220304 |
|
RJ01 | Rejection of invention patent application after publication |