CN114127127A - 嵌合的人***瘤病毒35型l1蛋白 - Google Patents
嵌合的人***瘤病毒35型l1蛋白 Download PDFInfo
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Abstract
本发明提供了嵌合的人***瘤病毒35型L1蛋白和编码其的多核苷酸，还提供了HPV 35型病毒样颗粒和其制备方法。该嵌合的人***瘤病毒35型L1蛋白包含衍生于HPV 35型L1蛋白的N端片段，该N端片段保持HPV 35型L1蛋白的免疫原性；和衍生于第二型别***瘤病毒L1蛋白的C端片段，该第二型别***状瘤病毒L1蛋白具有相较于其他型别的L1蛋白表达量和可溶性较好的特性；其中该嵌合的HPV 35型L1蛋白具有HPV 35型L1蛋白的免疫原性。该嵌合的人***瘤病毒35型L1蛋白具有较高的表达量和可溶性，可用于疫苗的大规模生产。
Description
PCT国内申请，说明书已公开。
Claims (23)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910656315 | 2019-07-19 | ||
| CN2019106563154 | 2019-07-19 | ||
| PCT/CN2020/102599 WO2021013070A1 (zh) | 2019-07-19 | 2020-07-17 | 嵌合的人***瘤病毒35型l1蛋白 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114127127A true CN114127127A (zh) | 2022-03-01 |
| CN114127127B CN114127127B (zh) | 2024-04-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080052245.2A Active CN114127127B (zh) | 2019-07-19 | 2020-07-17 | 嵌合的人***瘤病毒35型l1蛋白 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114127127B (zh) |
| WO (1) | WO2021013070A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2023008306A (es) * | 2021-01-14 | 2023-07-19 | Sinocelltech Ltd | Preparacion estable de una vacuna con particulas similares al virus de papilomavirus humano. |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001097840A1 (en) * | 2000-06-21 | 2001-12-27 | Medimmune, Inc. | Chimeric human papillomavirus (hpv) l1 molecules and uses therefor |
| CN106399329A (zh) * | 2015-08-12 | 2017-02-15 | 北京康乐卫士生物技术股份有限公司 | 33型重组人***瘤病毒病毒样颗粒及其制备方法 |
| CN106831959A (zh) * | 2015-12-04 | 2017-06-13 | 厦门大学 | 一种人***瘤病毒33型l1蛋白的突变体 |
| CN107188966A (zh) * | 2016-03-15 | 2017-09-22 | 中国医学科学院基础医学研究所 | 一种***瘤病毒嵌合蛋白及其用途 |
| CN109251236A (zh) * | 2017-07-14 | 2019-01-22 | 厦门大学 | 一种人***瘤病毒35型l1蛋白的突变体 |
-
2020
- 2020-07-17 WO PCT/CN2020/102599 patent/WO2021013070A1/zh active Application Filing
- 2020-07-17 CN CN202080052245.2A patent/CN114127127B/zh active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001097840A1 (en) * | 2000-06-21 | 2001-12-27 | Medimmune, Inc. | Chimeric human papillomavirus (hpv) l1 molecules and uses therefor |
| CN106399329A (zh) * | 2015-08-12 | 2017-02-15 | 北京康乐卫士生物技术股份有限公司 | 33型重组人***瘤病毒病毒样颗粒及其制备方法 |
| CN106831959A (zh) * | 2015-12-04 | 2017-06-13 | 厦门大学 | 一种人***瘤病毒33型l1蛋白的突变体 |
| CN107188966A (zh) * | 2016-03-15 | 2017-09-22 | 中国医学科学院基础医学研究所 | 一种***瘤病毒嵌合蛋白及其用途 |
| CN109251236A (zh) * | 2017-07-14 | 2019-01-22 | 厦门大学 | 一种人***瘤病毒35型l1蛋白的突变体 |
Non-Patent Citations (1)
| Title |
|---|
| DONG PAN等: "Enhanced expression of soluble human papillomavirus L1 through coexpression of molecular chaperonin in Escherichia coli", 《 PROTEIN EXPR PURIF》, vol. 120, pages 92 - 98, XP029393669, DOI: 10.1016/j.pep.2015.12.016 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114127127B (zh) | 2024-04-09 |
| WO2021013070A1 (zh) | 2021-01-28 |
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