CN114113620B - Card feeding and discharging mechanism for fluorescence immunoassay quantitative analyzer core - Google Patents
Card feeding and discharging mechanism for fluorescence immunoassay quantitative analyzer core Download PDFInfo
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- CN114113620B CN114113620B CN202210090646.8A CN202210090646A CN114113620B CN 114113620 B CN114113620 B CN 114113620B CN 202210090646 A CN202210090646 A CN 202210090646A CN 114113620 B CN114113620 B CN 114113620B
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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Abstract
The invention provides a card inlet and outlet mechanism for a fluorescence immunoassay quantitative analyzer core, which is characterized in that: including rotatable dish of hatching, the central point of dish of hatching puts and is provided with fixed carrier, the intermediate position of fixed carrier is provided with the measurement groove, the one end opening setting in measurement groove, the measurement groove top is provided with side by side measuring head and trip, measuring head and trip set up side by side along measurement groove length direction, measuring head and trip are connected with its first power device who is close to or keeps away from the measurement groove along the horizontal direction of drive, the trip is connected with its second power device who moves along vertical direction of drive. The problem of common instrument passageway uniformity not good has thoroughly been solved, directly withdraws from through hatching the dish from the measuring tank during withdrawing the card, and the reagent lath need not to continue to rotate on hatching the dish, also need not to use independent card withdrawing mechanism to withdraw the card, has reduced the stroke of reagent lath.
Description
Technical Field
The invention relates to fluorescence immunoassay, in particular to a card inlet and outlet mechanism for a fluorescence immunoassay quantitative analyzer core.
Background
The fluorescence immunoassay is used for analyzing and detecting a sample on the reagent strip, and the content of an analyte in the sample to be detected is automatically calculated by an instrument. The current fluorescence immunoassay needs to set up into card mechanism in the position of advancing the card, set up out card mechanism in the position of going out the card, carry the reagent lath to the draw-in groove of hatching the dish in, the reagent lath drives the detection position through hatching the dish, rotate out the card position after detecting again, dial the reagent lath down from the draw-in groove of hatching the dish by going out card mechanism, go out the card and advance the card and need two sets of different mechanisms, the part is many, make whole bulky, and the journey length of advancing out the card, be unfavorable for detection efficiency.
Disclosure of Invention
The invention aims to overcome the defects of the traditional technology and provides a card inlet and outlet mechanism for a fluorescence immunoassay quantitative analyzer core.
The aim of the invention is achieved by the following technical measures: the utility model provides a fluorescence immunity quantitative analysis appearance core is with business turn over card mechanism which characterized in that: including rotatable dish of hatching, the central point of dish of hatching puts and is provided with fixed carrier, the intermediate position of fixed carrier is provided with the measurement groove, the one end opening setting in measurement groove, the measurement groove top is provided with side by side measuring head and trip, measuring head and trip set up side by side along measurement groove length direction, measuring head and trip are connected with its first power device who is close to or keeps away from the measurement groove along the horizontal direction of drive, the trip is connected with its second power device who moves along vertical direction of drive.
As a preferred scheme, the output end of the first power device is connected with a synchronous belt, and the measuring head and the clamping hook are fixedly connected with the synchronous belt.
As a preferable scheme, a sliding table plate is fixedly connected to the synchronous belt, the second power device is fixed to the sliding table plate, and the output end of the second power device is in transmission connection with the clamping hook.
As a preferable scheme, the output end of the second power device is connected with a screw rod, a nut seat is sleeved on the screw rod, and the upper end of the clamping hook is fixedly connected with the nut seat.
As a preferable scheme, a second guide rail is arranged on the sliding table plate, the second guide rail is arranged along the vertical direction, the nut seat is fixedly connected with a second sliding block matched with the second guide rail, and the clamping hook is fixedly connected with the second sliding block.
As a preferred scheme, one end of the measuring groove is designed with a horn-mouth-shaped bevel edge, the other end of the measuring groove is designed with two mutually corresponding separation blades, one side of each of the two separation blades close to the measuring groove is parallel and level to be arranged, and a poking opening is arranged between the two separation blades.
As a preferred scheme, the cushion block is provided with a high boss and a low boss respectively on two sides of the measuring groove, a bearing plate is fixedly mounted on the upper plane of the high boss, and the first power device and the synchronous belt are mounted on the bearing plate.
As a preferred scheme, a plurality of clamping grooves are formed in the incubation disc, one end of the measuring groove is communicated with one of the clamping grooves, and the measuring groove is parallel and level to the clamping grooves.
As a preferred scheme, a supporting plate is arranged on the lower side of the incubation disc, a central main shaft is fixedly connected onto the supporting plate through a bolt, a cushion block is fixedly connected onto the central main shaft, and the fixed loader is fixedly connected onto the cushion block.
As a preferable scheme, a circle of convex rings are arranged on the circumference of the fixed carrier, and the convex rings are provided with bulges at the positions corresponding to the card inlets.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the advantages that: through the central point that puts at the dish of hatching and set up fixed carrier, intermediate position at fixed carrier is provided with the measurement groove, during the detection, push the reagent lath into the measurement inslot by the trip, after the detection finishes, directly dial out the reagent lath by the trip again, accomplish simultaneously and advance the card, detect and withdraw from the card, moreover, the steam generator is simple in structure, the volume of complete machine is reduced, simultaneously, need not to transport the reagent lath to the dish of hatching through extra mechanism, and need not to form the detection position of original place on the dish of hatching during the detection, detect a measurement groove with reagent lath sharing, thoroughly solved common instrument passageway uniformity not good problem, directly withdraw from the dish of hatching during withdrawing from the card through the measurement inslot, the reagent lath need not to continue to rotate on the dish of hatching, also need not to use independent card withdrawing mechanism and withdraws the card, the stroke of reagent lath has been reduced.
The invention is further described with reference to the following figures and detailed description.
Drawings
Fig. 1 is a schematic view of the overall structure of a card inlet and outlet mechanism for a fluorescence immunoassay quantitative analyzer movement of the present invention.
Fig. 2 is a schematic view of a first motor transmission structure of a card inlet and outlet mechanism for a fluorescence immunoassay quantitative analyzer movement of the present invention.
Fig. 3 is a schematic diagram of a cross-sectional structure of a pad block of a card inlet and outlet mechanism for a fluorescence immunoassay quantitative analyzer core of the present invention.
Fig. 4 is a schematic structural view of a fixed carrier of an inlet and outlet card mechanism for a fluorescence immunoassay quantitative analyzer movement of the invention.
Fig. 5 is a schematic view of a measuring head transmission structure of a card inlet and outlet mechanism for a fluorescence immunoassay quantitative analyzer movement of the present invention.
Fig. 6 is a schematic view of a measuring groove structure of a card inlet and outlet mechanism for a fluorescence immunoassay quantitative analyzer movement of the invention.
Fig. 7 is a schematic diagram of a hook transmission structure of a card inlet and outlet mechanism for a fluorescence immunoassay quantitative analyzer core of the present invention.
In the figure:
1-a supporting plate; 2-connecting a column; 3-a lower shell; 4-front cover plate; 5-a rear cover plate; 6-incubation plate; 7-a clamping groove; 8-a first pillar; 9-a seat board; 10-a leg; 11-a central main axis; 12-cushion blocks; 13-a fixed carrier; 14-a scaffold; 15-measuring groove; 16-a spring plate; 17-a baffle plate; 18-a bayonet; 19-a convex ring; 20-bulge; 21-a measuring head; 22-a hook; 23-a first motor; 24-a carrier plate; 25-high boss; 26-short boss; 27-a second pillar; 28-synchronous belt; 29-a synchronous pulley; 30-a first guide rail; 31-a platen; 32-a first slider; 33-a second motor; 34-a screw rod; 35-nut seats; 36-a second slider; 37-a third slider; 38-optical coupling stop sheet; 39-left side optocoupler; 40-a middle optocoupler; 41-right side optical coupler; 42-second guide rail.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the equipment or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
Example (b): as shown in fig. 1-7, a fluorescence immunity quantitative analyzer is business turn over card mechanism for core, including layer board 1, layer board 1 top is through spliced pole 2 fixedly connected with inferior valve 3, 3 upside fixed mounting of inferior valve have front shroud 4 and back shroud 5, form the cavity that is used for detecting between inferior valve 3 and front shroud 4 and the back shroud 5, be provided with rotatable hatching dish 6 in the cavity, be provided with the draw-in groove 7 that holds the reagent lath on hatching dish 6, draw-in groove 7 is along hatching 6 radial settings of dish, in this embodiment, draw-in groove 7 evenly is provided with 16.
The lower part of the supporting plate 1 is connected with a seat plate 9 through a first supporting column 8, the bottom of the seat plate 9 is provided with a supporting leg 10, and the seat plate 9 is placed on a detection table top for use. The supporting plate 1, the seat plate 9 and the lower shell 3 are integrally arranged in parallel.
As shown in fig. 3, a central spindle 11 is fixedly connected to the upper side of the supporting plate 1 through bolts, a cushion block 12 is fixedly connected to the upper side of the central spindle 11 through bolts, a fixed carrier 13 is fixedly connected to the upper side of the cushion block 12, and the fixed carrier 13 is located at the center of the incubation plate 6.
As shown in fig. 6, the upper surface of the spacer 12 is formed with an elongated groove, the central surfaces of the two vertical surfaces of the groove pass through the axial line of the spacer 12, the fixed carrier 13 is positioned in the groove, and the fixed carrier 13 is fixed to the spacer 12 by screws. The centre of the fixed carrier 13 is arranged coincident with the centre of the incubation plate 6. The lower contact surface of the fixed carrier 13 with the reagent strip is in a plane with the bottom surface of the 16 strip slots 7 in the incubation plate 6.
When the reagent laths in the 16 lath clamping grooves 7 on the incubation disc 6 are measured, the reagent laths are pushed into the same fixed carrier 13, and a measuring head is used for measurement, so that the problem of poor consistency of the channels of the common instrument is thoroughly solved. The fixed carrier 13 is made of a plastic material or a metal material. As shown in fig. 6, a measuring groove 15 is disposed in the middle of the fixed carrier 13, a spring 16 is respectively mounted on the bottom and a side of the measuring groove 15 for fixing the reagent strip placed therein, one end of the measuring groove 15 is used for feeding and discharging the reagent strip, a horn-mouth-shaped bevel edge is designed at one end of the feeding and discharging card, the reagent strip is conveniently butted with one of the 16 strip slots 7 on the incubation disc 6 when the reagent strip is fed into and discharged from the fixed carrier 13, two corresponding blocking pieces 17 are designed at the other end of the measuring groove 15, and one side of the two blocking pieces 17 close to the measuring groove 15 is flush and level for positioning the reagent strip in the card feeding direction. A card-pulling opening 18 with the width of 11 mm is reserved between the two blocking pieces 17 and is used for the passing of the card hook during card withdrawing. When detecting the reagent lath, push into the measuring groove 15 with the reagent lath from the draw-in groove 7 that corresponds with measuring groove 15 in, the separation blade 17 of the measuring groove 15 other end is injectd the position of reagent lath direction of motion, and two shell fragments 16 fix a position two other vertical directions of reagent lath, and the location is simple, and is quick, need not extra positioner and can realize the accurate positioning, and has effectively simplified holistic structure. A circle of convex rings 19 are arranged on the circumference of the fixed carrier 13, the convex rings 19 are provided with bulges 20 at the positions corresponding to the card inlet, and when the card is inserted, the bulges 20 play a role in limiting the front end surface of the reagent plate strip.
As shown in fig. 1, 2 and 5, a measuring head 21 and a hook 22 are disposed above the measuring slot 15, the measuring head 21 and the hook 22 are disposed side by side along the moving direction of the reagent strip in the measuring slot 15, the measuring head 21 and the hook 22 are connected to a first power device for driving the measuring head to approach or leave the measuring slot 15, the first power device is a first motor 23, the first motor 23 is mounted on a bearing plate 24, and the bearing plate 24 is located above the back cover plate 5. The two sides of the strip-shaped groove of the cushion block 12 are respectively provided with a high boss 25 and a low boss 26. The lower plane of the carrier plate 24 is mounted on the upper plane of the raised boss 25 and positioned by two pins and secured with screws. The carrier plate 24 is supported at its four corners on the pallet 1 by four second support struts 27. For the carrier plate 24, the spacer 12 is the main support and the four second struts 27 are the auxiliary supports.
As shown in FIGS. 2 and 5, the movement direction of the hook 22 is the same as the movement direction of the reagent strip in the measurement slot 15, and a timing belt 28 is further provided on the carrier plate 24, and the timing belt 28 is also provided along the movement direction of the reagent strip in the measurement slot 15. Two ends of the synchronous belt 28 are respectively provided with a synchronous belt pulley 29, the synchronous belt pulleys 29 are mounted on the bearing plate 24 through the bracket 14, one synchronous belt pulley 29 is in transmission connection with the first motor 23, and the synchronous belt 28 is driven by the first motor 23 to move along the movement direction of the reagent strip in the measuring groove 15. The lower side of the synchronous belt 28 is provided with a first guide rail 30, the first guide rail 30 is fixed on the bearing plate 24, and the first guide rail 30 is arranged in parallel with the synchronous belt 28.
As shown in fig. 2 and 7, the hook 22 is connected on the sliding table plate 31, the sliding table plate 31 is arranged on one side of the synchronous belt 28 close to the measuring groove 15, the sliding table plate 31 is fixedly connected with a first sliding block 32 on one side of the synchronous belt 28 close to the sliding table plate 31, the first sliding block 32 is arranged in cooperation with the guide rail 30, the sliding table plate slides along the first guide rail 30, the first sliding block 32 is fixedly connected with the synchronous belt 28, the first motor 23 transmits power to the synchronous belt 28, the synchronous belt 28 drives the first sliding block 32 to reciprocate along the movement direction of the reagent plate strip in the measuring groove 15, and the hook 22 is driven to move.
When the card is fed in and out, the horizontal height of the clamping hook 22 is higher than the bottom heights of the clamping groove 7 and the measuring groove 15 and lower than the heights of the reagent strip plates in the clamping groove 7 and the measuring groove 15. The initial position of the hook 22 is located as shown in fig. 2, the end of the card slot 7 far away from the measuring groove 15 is started by the first motor 23, the synchronous belt 28 drives the hook 22 to move towards the measuring groove 15, the hook 22 shifts the reagent strip into the measuring groove 15, the reagent strip is precisely positioned in the measuring groove 15 through the elastic sheet 16 and the blocking sheet 17, and card feeding is completed.
As shown in fig. 2 and 7, a second power device for driving the hook 22 to move toward or away from the incubation disc 6 is connected to the sliding table plate 31, in this embodiment, the second power device is a second motor 33, the second motor 33 is fixed on the sliding table plate 31, an output end of the second motor 33 is connected to a lead screw 34, a nut seat 35 is sleeved on the lead screw 34, an upper end of the hook 22 is fixedly connected to the nut seat 35, a second guide rail 42 is arranged on the sliding table plate 31, the second guide rail 42 is arranged along a vertical direction, a second slider 36 matched with the second guide rail 30 is fixedly connected to the nut seat 35, and the hook 22 is fixedly connected to the second slider 36. Thus, the second motor 33 drives the nut seat 35 and the second sliding block 36 to move in the vertical direction, and the second sliding block 36 drives the hook 22 to reciprocate in the vertical direction.
The reagent strip enters the fixed carrier 13 from the incubation plate 6 and then exits from the fixed carrier 13, and the action function can be completed only by one set of components. When reagent laths are required to enter the fixed carrier 13, one of the lath clamping grooves 7 on the incubation disc 6 is firstly aligned with the bell mouth of the fixed carrier 13, the clamping hook 22 moves to the outer side of the end part of the reagent lath in the incubation disc 6 under the driving of the first motor 23, then the clamping hook 22 descends to the position with the horizontal height between the bottom surface of the clamping groove 7 and the reagent lath under the action of the second motor 33, and the first motor 23 drives the clamping hook 22 to push the reagent lath into the fixed carrier 13. When reagent laths need to be withdrawn from the fixed carrier 13, the clamping hook 22 is moved to the left position of the fixed carrier 13, the clamping hook 22 is lowered to the position of pushing the reagent laths, and the reagent laths are pushed into the lath clamping grooves 7 on the incubation disc 6 from the fixed carrier 13 until being pushed out of the lath clamping grooves 7 on the incubation disc 6 and entering the outlet clamping grooves 7.
Measuring head 21 and trip 22 sharing second motor 33 realize the removal of horizontal direction, and measuring head 21 fixedly connected with third slider 37, third slider 37 fix on hold-in range 28, and slide along first guide rail 30 with the cooperation of first guide rail 30 and set up, realize first slider 32 and third slider 37's linkage through a hold-in range 28. As shown in fig. 5, a left optical coupler 39, a middle optical coupler 40, and a right optical coupler 41 are sequentially disposed on the bearing plate 24 along the horizontal direction, and an optical coupler blocking sheet 38 is fixedly connected to the first slider 32 to jointly control the positions of the measuring head 21 and the hook 22 on the first guide rail 30.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (7)
1. The utility model provides a fluorescence immunity quantitative analysis appearance core is with business turn over card mechanism which characterized in that: the multifunctional incubator comprises a rotatable incubation disc, a fixed carrier is arranged at the central position of the incubation disc, a measuring groove is arranged at the middle position of the fixed carrier, one end of the measuring groove is provided with an opening, a side-by-side measuring head and a clamping hook are arranged above the measuring groove, the measuring head and the clamping hook are arranged side by side along the length direction of the measuring groove, the measuring head and the clamping hook are connected with a first power device for driving the measuring head to be close to or away from the measuring groove along the horizontal direction, the clamping hook is connected with a second power device for driving the measuring head to move along the vertical direction, the output end of the first power device is connected with a synchronous belt, the measuring head and the clamping hook are both fixedly connected with the synchronous belt, one end of the measuring groove is designed with a horn-mouth-shaped bevel edge, the other end of the measuring groove is designed with two corresponding separation blades, one sides of the two separation blades close to the measuring groove are arranged in a parallel and level manner, and a poking port is arranged between the two separation blades, a plurality of clamping grooves are formed in the incubation disc, one end of the measuring groove is communicated with one clamping groove, and the measuring groove is parallel and level to the clamping grooves.
2. The fluorescence immunity quantitative analyzer core of claim 1 is with going in and out card mechanism, characterized in that: the synchronous belt is fixedly connected with a sliding table plate, the second power device is fixed on the sliding table plate, and the output end of the second power device is in transmission connection with the clamping hook.
3. The fluorescence immunity quantitative analyzer core of claim 2 is with going in and out card mechanism, characterized in that: the output end of the second power device is connected with a screw rod, a nut seat is sleeved on the screw rod, and the upper end of the clamping hook is fixedly connected with the nut seat.
4. The fluorescence immunity quantitative analyzer core of claim 3 is with going in and out card mechanism, characterized in that: the nut seat is fixedly connected with a second sliding block matched with the second guide rail, and the clamping hook is fixedly connected with the second sliding block.
5. The fluorescence immunity quantitative analyzer core of claim 1 is with going in and out card mechanism, characterized in that: the lower side of the incubation disc is provided with a supporting plate, the supporting plate is fixedly connected with a central main shaft through a bolt, the central main shaft is fixedly connected with a cushion block, and the fixed loader is fixedly connected onto the cushion block.
6. The fluorescence immunity quantitative analyzer core of claim 5 is with going in and out card mechanism, characterized in that: the cushion is provided with high boss and short boss respectively in the both sides of measuring groove, fixed mounting has the loading board on the last plane of high boss, first power device and hold-in range are all installed on the loading board.
7. The fluorescence immunity quantitative analyzer core of claim 1 is with going in and out card mechanism, characterized in that: the circumference of the fixed loader is provided with a circle of convex rings, and the convex rings are provided with bulges at the positions corresponding to the card inlets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210090646.8A CN114113620B (en) | 2022-01-26 | 2022-01-26 | Card feeding and discharging mechanism for fluorescence immunoassay quantitative analyzer core |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210090646.8A CN114113620B (en) | 2022-01-26 | 2022-01-26 | Card feeding and discharging mechanism for fluorescence immunoassay quantitative analyzer core |
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| CN114113620A CN114113620A (en) | 2022-03-01 |
| CN114113620B true CN114113620B (en) | 2022-03-29 |
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| CN202210090646.8A Active CN114113620B (en) | 2022-01-26 | 2022-01-26 | Card feeding and discharging mechanism for fluorescence immunoassay quantitative analyzer core |
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| CN113804906A (en) * | 2021-10-19 | 2021-12-17 | 中秀科技股份有限公司 | Full-automatic fluorescent quantitative analyzer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE369915T1 (en) * | 1998-05-01 | 2007-09-15 | Gen Probe Inc | INCUBATOR FOR AUTOMATIC ANALYZER |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN204495721U (en) * | 2015-04-24 | 2015-07-22 | 广州蓝勃生物科技有限公司 | Performance carousel entry solid phase fluorescent tester |
| CN105572407A (en) * | 2016-01-27 | 2016-05-11 | 广州万孚生物技术股份有限公司 | Full-automatic fluorescent quantitative immunity analyzer and detection method |
| CN105866452A (en) * | 2016-05-24 | 2016-08-17 | 湖南迪赛生物科技有限公司 | Multi-channel dry type immunofluorescence detector |
| CN107389915A (en) * | 2017-08-15 | 2017-11-24 | 广州源起健康科技有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter |
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| CN113804906A (en) * | 2021-10-19 | 2021-12-17 | 中秀科技股份有限公司 | Full-automatic fluorescent quantitative analyzer |
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| Publication number | Publication date |
|---|---|
| CN114113620A (en) | 2022-03-01 |
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