CN114113574B - Compact integrated multichannel fluorescence immunoassay quantitative analyzer core - Google Patents

Abstract

The invention provides a compact integrated multichannel fluorescence immunoassay quantitative analyzer movement, which comprises a lower shell, a front cover plate and a rear cover plate, wherein the front cover plate and the rear cover plate are arranged on the upper side of the lower shell, a cavity for detection is arranged among the lower shell, the front cover plate and the rear cover plate, a rotatable incubation disc is arranged in the cavity, a clamping groove for containing a plate strip is arranged on the incubation disc, a notch for card entering and a card outlet guide groove for card outlet are arranged on the lower shell, the incubation disc rotates along the direction from the notch to the card outlet guide groove, a fixed bearing device is arranged in the middle of the incubation disc, a detection groove is arranged on the fixed bearing device, one end of the detection groove faces to an opening of the card outlet guide groove, and a measuring head and a clamping hook are arranged on one side of the detection groove. The whole volume is small, and the structure is simple; the whole structure is simplified; the accurate positioning of the reagent plate strip can be realized without an additional positioning device, the arrangement of a positioning mechanism is further reduced, the integral structure is greatly reduced, and the reagent plate strip positioning device is favorable for being used in small and medium hospitals and clinics.

Description

Compact integrated multichannel fluorescence immunoassay quantitative analyzer core

Technical Field

The invention relates to an immune quantitative analyzer, in particular to a compact integrated multichannel fluorescence immune quantitative analyzer core.

Background

The fluorescence immunoassay is a high-efficiency detection method derived by fusing the immunological disciplines under the support of the fluorescence technology.

The detection process of the fluorescence immunoassay quantitative analyzer based on the development of the fluorescence immunoassay technology is as follows: firstly, the detection sample which is fully and uniformly mixed by the buffer solution is added into a sample adding hole of the reagent strip, and an analyte in the sample forms an immune complex in the chromatography process. A laser diode is used as an excitation light source which is irradiated onto the detection area on the reagent strip to excite the attached fluorescent substance. The emitted light is collected and converted into an electric signal, the strength of the electric signal is strictly related to the quantity of fluorescent molecules, and the detecting instrument automatically calculates the content of the analyte in the sample to be detected.

The fluorescence immunoassay quantitative analyzer has strong functions and a plurality of detection types, is suitable for various projects, has the advantages of high speed, high sensitivity, high accuracy and the like, becomes an important component in clinical detection, and is widely applied to the detection of the projects such as cardiac markers, inflammation markers, kidney markers and the like. The fluorescence immunoassay quantitative analyzer can be widely applied to departments such as cardiology, clinical laboratory, emergency department, ICU, oncology, nephrology, pediatrics, endocrinology, gynecology, geriatrics, pneumology, thoracic surgery, gastroenterology, urology and the like in various hospitals, and has a good development prospect.

With the rapid development of basic medicine and clinical medicine, new requirements and challenges are put on medical examination, and in recent years, with the increasing number of patients for hospital diagnosis and treatment, the operating pressure and the working strength of inspectors in hospital clinical laboratories and clinics are increased. Large-scale full-automatic fluoroimmunoassay quantitative analyzers and "full laboratory automation and integration" pipeline workstations have been adopted in many large hospitals.

In many places such as small and medium hospitals and clinics where examination means are required, the number of patients increases, but the number of examination samples is not large enough to support the use of large examination equipment. The market needs an instrument which is used for small and medium-sized hospitals and clinics and has the characteristics of rapidness, simplicity, convenience, miniaturization, high efficiency and practicability to meet the requirement.

Disclosure of Invention

The invention aims to overcome the defects of the traditional technology and provides a compact integrated multichannel fluorescence immunoassay quantitative analyzer core.

The aim of the invention is achieved by the following technical measures: the utility model provides a compact integration multichannel fluorescence immunity quantitative analysis appearance core which characterized in that: comprises a lower shell, a front cover plate and a rear cover plate which are arranged on the upper side of the lower shell, wherein a cavity for detection is arranged among the lower shell, the front cover plate and the rear cover plate, a rotatable incubation disc is arranged in the cavity, a clamping groove for holding the batten is arranged on the incubation disc, the lower shell is provided with a notch for card entering and a card outlet guide groove for card outlet, the incubation disc rotates along the direction from the notch to the card outlet guide groove, a fixed carrier is arranged at the middle position of the incubation disc, a detection groove is arranged on the fixed carrier, one end of the detection groove is arranged towards the opening of the card outlet guide groove, one side of the detection groove is provided with a measuring head and a clamping hook, the measuring head and the clamping hook are arranged side by side along the direction from the detection groove to the card outlet guide groove, the measuring head and the clamping hook are connected with a second power device for driving the measuring head and the clamping hook to move, and the clamping hook is connected with a third power device for driving the measuring head to reciprocate along the vertical direction.

As a preferable scheme, the output end of the second power device is connected with a second synchronous belt, the hook is connected to the sliding table plate, the sliding table plate is arranged on one side of the second synchronous belt close to the detection groove, a first sliding block is fixedly connected to one side of the sliding table plate close to the second synchronous belt, the first sliding block is fixedly connected with the second synchronous belt, the measuring head is fixedly connected with a third sliding block, and the third sliding block is fixed on the second synchronous belt.

As a preferable scheme, the output end of the third power device is connected with a screw rod, a nut seat is sleeved on the screw rod, and the upper end of the clamping hook is fixedly connected with the nut seat.

As a preferable scheme, a second guide rail is arranged on the sliding table plate, the second guide rail is arranged along the vertical direction, the nut seat is fixedly connected with a second sliding block matched with the second guide rail, and the clamping hook is fixedly connected with the second sliding block.

As an optimal scheme, one end of the detection groove is provided with a horn-mouth-shaped bevel edge, the other end of the detection groove is provided with two mutually corresponding separation blades, the separation blades are arranged at one side of the detection groove in a parallel and level mode, and a poking opening is formed between the separation blades.

As a preferred scheme, it is provided with the layer board to hatch a set downside, through bolt fixedly connected with central main shaft on the layer board, fixedly connected with cushion on the central main shaft, fixed loader fixed connection is on the cushion, the cushion is provided with high boss and short boss respectively in the both sides of detecting the groove, fixed mounting has the loading board on the last plane of high boss, second power device and second hold-in range are all installed on the loading board.

As a preferred scheme, a first power device for driving the incubation disc to rotate is arranged on the supporting plate, a first synchronous belt wheel is installed at the output end of the first power device, a second synchronous belt wheel is sleeved on the outer side of the central main shaft through a bearing, a first synchronous belt is sleeved between the first synchronous belt wheel and the second synchronous belt wheel, a rotary main shaft is fixedly connected onto the second synchronous belt wheel through a bolt, and the rotary main shaft is fixedly connected with the incubation disc through a bolt.

As an optimal scheme, install the storehouse door shield on the breach, the rear side of storehouse door shield is provided with hatch a parallel and level put the card platform, the outside of putting the card platform is provided with the guide slot, the outside of storehouse door shield is provided with the sliding tray along vertical direction, is provided with slidable shutter piece in the sliding tray, shutter piece is connected with its fourth power device along the sliding tray gliding of drive, the outside of storehouse door shield is provided with the protective housing, be provided with on the protective housing with the corresponding bayonet socket of putting of shutter piece, the guide slot sets up with hatch one of them draw-in groove intercommunication on the dish.

As a preferred scheme, the cabin door cover is fixedly connected with a correlation fixing frame, the correlation fixing frame is provided with correlation optical couplers, the correlation optical couplers are arranged on two sides of the cabin door cover, and a vacant area is arranged between the correlation optical couplers.

As a preferred scheme, the shutter piece main body is plate-shaped, the fourth power device is arranged at the lower end of the shutter piece, the fourth power device is a fourth motor, the output end of the fourth motor is fixedly connected with a connecting piece, the connecting piece is arranged along the horizontal direction, the connecting piece is fixedly connected with the shutter piece through a bolt, the connecting piece is connected with a guide rod, and the guide rod is arranged along the movement direction of the shutter piece.

Due to the adoption of the technical scheme, compared with the prior art, the invention has the advantages that: the fixed carrier is arranged at the center of the incubation disc, the detection groove is arranged at the middle position of the fixed carrier, when in detection, the reagent strip is pushed into the detection groove by the clamping hook, and after the detection is finished, the reagent strip is directly pulled out by the clamping hook, and the card feeding, the detection and the card withdrawing are simultaneously completed, so that the structure is simple, the volume of the whole machine is reduced, meanwhile, the reagent strip is not required to be transported to the incubation disc by an additional mechanism, and the in-situ detection position is not required to be formed on the incubation disc during the detection, the reagent strip is detected by sharing one detection groove, the problem of poor consistency of common instrument channels is thoroughly solved, the reagent strip directly withdraws from the detection groove through the incubation disc during the card withdrawing, the reagent strip does not need to continuously rotate on the incubation disc, and an independent card withdrawing mechanism is not required to withdraw, and the stroke of the reagent strip is reduced; the bin door cover is arranged at the notch of the lower shell, the openable or closable door blocking piece is arranged on the bin door cover, when a reagent plate strip needs to be placed, the door blocking piece is opened, and after the placement is finished, the door blocking piece is automatically closed, so that the influence on the internal environment can be effectively reduced, the detection data is more accurate, the reagent plate strip is directly placed on the clamping groove of the incubation disc during the card placement, the transportation and the carrying of other parts are not needed, the number and the volume of the card feeding assemblies are reduced, the movement route of the reagent plate strip is also saved, the whole volume is small, and the structure is simple; the fixed carrier is arranged at the center of the incubation disc, the detection groove is arranged in the middle of the fixed carrier, and the reagent plate strip is positioned in the detection groove during detection, so that the material and area of the incubation disc can be reduced, the detection position formed on the incubation disc can be avoided, the use of parts is reduced, and the integral structure is simplified; the accurate positioning of the reagent plate strip can be realized without an additional positioning device, the arrangement of a positioning mechanism is further reduced, the integral structure is greatly reduced, and the reagent plate strip positioning device is favorable for being used in small and medium hospitals and clinics.

The invention is further described with reference to the following figures and detailed description.

Drawings

Fig. 1 is a schematic diagram of the overall structure of a compact integrated multichannel fluorescence immunoassay quantitative analyzer core.

Fig. 2 is a schematic diagram of the internal structure of the compact integrated multi-channel fluorescence immunoassay quantitative analyzer core.

Fig. 3 is a schematic sectional structure diagram of a compact integrated multichannel fluorescence immunoassay quantitative analyzer core.

Fig. 4 is a schematic structural view of a card outlet guide groove of a compact integrated multi-channel fluorescence immunoassay quantitative analyzer core.

Fig. 5 is a schematic diagram of a second motor transmission structure of the compact integrated multichannel fluorescence immunoassay quantitative analyzer core.

FIG. 6 is a schematic diagram of a detection slot structure of a compact integrated multi-channel fluorescence immunoassay analyzer core.

Fig. 7 is a schematic diagram of a trip transmission structure of a compact integrated multichannel fluorescence immunoassay quantitative analyzer core of the present invention.

FIG. 8 is a schematic view of a shutter plate of a compact integrated multi-channel fluorescence immunoassay analyzer core according to the present invention.

Fig. 9 is a schematic view of a guide groove structure of a compact integrated multi-channel fluorescence immunoassay quantitative analyzer core of the invention.

Fig. 10 is a schematic structural diagram of a light projector of a compact integrated multichannel fluorescence immunoassay quantitative analyzer core.

FIG. 11 is a schematic diagram of a sliding groove structure of a compact integrated multi-channel fluorescence immunoassay analyzer core.

In the figure:

1-a lower shell; 2-a bottom plate; 3-side plate; 4-front cover plate; 5-a rear cover plate; 6-connecting lugs; 7-incubation plate; 8-a clamping groove; 9-a supporting plate; 10-a first strut; 11-a seat plate; 12-a leg; 13-a notch; 14-card outlet guide slot; 15-fixing the carrier; 16-a detection tank; 17-a measuring head; 18-a stepper motor; 19-a first synchronization belt; 20-a first synchronous pulley; 21-a second synchronous pulley; 22-a central main axis; 23-a bearing; 24-a rotating main shaft; 25-cushion block; 26-central large pore; 27-a rotating grating; 28-a spring plate; 29-baffle plate; 30-pulling the bayonet; 31-a convex ring; 32-protrusions; 33-a second motor; 34-a carrier plate; 35-high boss; 36-short boss; 37-a hook; 38-a second synchronous belt; 39-a third synchronous pulley; 40-a scaffold; 41-a first guide rail; 42-a platen; 43-a first slide; 44-a second slide; 45-a third slider; 46-a third motor; 47-a screw rod; 48-nut seats; 49-a second guide rail; 50-left side optical coupler; 51-a middle optocoupler; 52-right side optocoupler; 53-a second light coupling baffle; 54-connecting block; 55-bin door cover; 56-card placing platform; 57-a guide groove; 58-correlation fixing frame; 59-correlation optical coupler; 60-a sliding groove; 61-a door stop sheet; 62-a fourth motor; 63-connecting sheets; 64-a guide rod; 65-protective shell; 66-a light projector; 67-a light receptor; 68-high and low position reflecting optical couplers; 69-heating the film.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the equipment or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

Example (b): as shown in fig. 1-11, a compact integrated multichannel fluorescence immunoassay quantitative analyzer core comprises a frame, wherein a lower shell 1 is fixedly connected to the frame, the lower shell 1 comprises a bottom plate 2 and a side plate 3 arranged in the circumferential direction of the bottom plate 2, the lower end of the side plate 3 is fixed to the bottom plate 2, a front cover plate 4 and a rear cover plate 5 are fixedly connected to the upper end of the side plate 3, a plurality of connecting lugs 6 are arranged between the front cover plate 4 and the side plate 3 along the circumferential direction, and the corresponding connecting lugs 6 are fixedly connected through bolts.

As shown in fig. 2, 3 and 5, a cavity for detection is provided between the lower casing 1 and the front cover plate 4 and the rear cover plate 5, a rotatable incubation disc 7 is provided in the cavity, a clamping groove 8 for holding reagent strip is provided on the incubation disc 7, the clamping groove 8 is radially provided along the incubation disc 7, and in this embodiment, 16 clamping grooves are uniformly provided on the clamping groove 8.

The frame includes layer board 9, and layer board 9 top is connected with inferior valve 1 through spliced pole fixedly connected with, and layer board 9 below is connected with bedplate 11 through first pillar 10, and the bottom of bedplate 11 is provided with stabilizer blade 12, lays bedplate 11 and uses on detecting the mesa. The supporting plate 9, the seat plate 11 and the lower shell 1 are integrally arranged in parallel.

As shown in fig. 2 and 4, a front cover plate 4 and a rear cover plate 5 are fixedly mounted on the upper side of the lower casing 1, the lower casing 1 is circular, a notch 13 is formed in one side of the lower casing 1 and used for placing a reagent strip into the incubation disc 7, and a card outlet guide groove 14 is formed in one side of the lower casing 1 and used for pushing out the detected reagent strip. In this embodiment, the angle between the notch 13 and the center of the incubation plate 7 and the angle between the card-out guide 14 and the center of the incubation plate 7 are 90 degrees. Incubation dish 7 central point puts and is provided with fixed carrier 15, be provided with on the fixed carrier 15 and detect groove 16, it is provided with measuring head 17 to detect groove 16 correspondence, when detecting, the reagent lath enters into by breach 13 on incubating dish 7, incubate dish 7 drive down follow rotate to with play card guide slot 14 correspond department, push away the reagent lath to fixed carrier 15 on detect the back through measuring head 17's detection in the groove 16, again by play card guide slot 14 roll-off.

As shown in fig. 3, a first power device is arranged on the supporting plate 9, the first power device is a stepping motor 18, a first synchronous pulley 20 is installed at an output end of the stepping motor 18, a central spindle 22 is fixedly connected to the supporting plate 9, a second synchronous pulley 21 is sleeved outside the central spindle 22 through a bearing 23, a first synchronous belt 19 is sleeved between the first synchronous pulley 20 and the second synchronous pulley 21, a rotary spindle 24 is fixedly connected to the second synchronous pulley 21 through a bolt, the rotary spindle 24 is fixedly connected to the incubation disk 7 through a bolt, the first power device transmits power to the rotary spindle 24 through the second synchronous pulley 21 to drive the rotary spindle 24 to rotate, the rotary spindle 24 drives the incubation disk 7 to rotate, and the incubation disk 7 drives the reagent strips to move.

As shown in fig. 3, in this embodiment, the central spindle 22 and the incubation disc 7 are concentrically arranged, the central spindle 22 is fixed on the supporting plate 9 by a bolt and connected with the second pulley by a bearing 23, when the second synchronous pulley rotates, the central spindle 22 is in a stationary state, a cushion block 25 is fixedly connected to the upper side of the central spindle 22, the cushion block 25 is fixedly connected with the central spindle 22 by a bolt, the upper side of the cushion block 25 is fixedly connected with the fixed carrier 15, and the reagent strip enters the detection groove of the fixed carrier 15 for detection. The incubation disc 7 is arranged on the upper end face of the rotary main shaft 24, penetrates through the shockproof compression ring, the backing ring and the incubation disc 7 from top to bottom through screws, fixes the incubation disc 7 and the rotary main shaft 24, and ensures that the incubation disc 7 and the rotary main shaft 24 cannot generate displacement through two pins; the central positions of the rotary main shaft 24 and the incubation disc 7 are both provided with central large holes 26 which are overlapped with each other, and the cushion block 25 is positioned in the central large hole 26, so that the rotation of the rotary main shaft 24 and the incubation disc 7 is not hindered after the cushion block 25 passes through. The stepping motor 18 is arranged on one side of the central spindle 22, and the incubation disk 7 is fixed with the supporting plate 9 through a driving motor.

The cushion block 25 and the incubation disc 7 are also coaxially arranged, and the cushion block 25 is fixed with the central main shaft 22 and is always in a static state. A rotary grating 27 is arranged between the second synchronous belt wheel 21 and the rotary main shaft 24, and a grating optical coupler matched with the rotary grating 27 is arranged on the supporting plate 9.

As shown in fig. 3-6, the upper surface of the spacer 25 is formed with a strip-shaped groove, the central planes of the two vertical surfaces of the groove pass through the axial line of the spacer 25, the fixed carrier 15 is positioned in the groove, and the fixed carrier 15 is fixed with the spacer 25 by a screw. The centre of the fixed carrier 15 is arranged coincident with the centre of the incubation plate 7. The lower contact surface of the fixed carrier 15 with the reagent strip is in a plane with the bottom surface of the 16 strip slots 8 in the incubation plate 7.

When the reagent laths in the 16 lath clamping grooves 8 on the incubation disc 7 are measured, the reagent laths are pushed into the same fixed carrier 15 and are measured by a common measuring head 17, so that the problem of poor consistency of the channels of the common instrument is thoroughly solved. The fixed carrier 15 is made of a plastic material or a metal material. As shown in fig. 6, a detection groove 16 is disposed in the middle of the fixed carrier 15, a spring plate 28 is respectively disposed at the bottom and a side of the detection groove 16 for fixing the reagent strip placed therein, one end of the detection groove 16 is used for feeding and discharging the reagent strip, a horn-mouth-shaped bevel edge is designed at one end of the feeding and discharging card, so that the reagent strip can be conveniently butted with one of the 16 strip slots 8 of the incubation tray 7 when the reagent strip is fed into and discharged from the fixed carrier 15, two corresponding blocking pieces 29 are designed at the other end of the detection groove 16, and one side of each of the two blocking pieces 29 close to the detection groove 16 is flush with the other side of the detection groove for positioning the reagent strip in the card feeding direction. A card-pulling opening 30 with the width of 11 mm is reserved between the two blocking pieces 29 and is used for the passing of the card hook during card withdrawing. When detecting the reagent lath, push into the detection groove 16 with the reagent lath from the draw-in groove 8 that corresponds with the detection groove 16, detect the separation blade 29 of the groove 16 other end and prescribe a limit to the position of reagent lath direction of motion, two shell fragments 28 fix a position the other two vertical directions of reagent lath, and the location is simple, and is quick, need not extra positioner and can realize the accurate positioning, and has effectively simplified holistic structure. The circumference of fixed carrier 15 is provided with round bulge loop 31, and fixed carrier 15 sets up with bulge loop 31 is integrative, and bulge 32 is provided with in bulge loop 31 and advancing the card department of correspondence, advances the card time, and bulge 32 plays limiting displacement to the preceding terminal surface of reagent lath.

As shown in fig. 1, 2 and 5, the measuring head 17 is connected to a second power device for driving the measuring head to move close to or away from the detecting slot 16, the second power device is a second motor 33, the second motor 33 is mounted on a bearing plate 34, and the bearing plate 34 is located above the rear cover plate 5. The two sides of the strip-shaped groove of the cushion block 25 are respectively provided with a high boss 35 and a low boss 36. The lower plane of the carrier plate 34 is mounted on the upper plane of the raised boss 35 and positioned by two pins and fixed by screws. The four corners of the carrier plate 34 are supported on the pallet 9 by four second support posts. For the bearing plate 34, the cushion block 25 is a main support, and the four second pillars are auxiliary supports.

As shown in fig. 1, 2 and 5, the measuring head 17 is disposed above the detecting slot 16, the measuring head 17 is further provided with a hook 37 side by side, the measuring head 17 and the hook 37 are disposed side by side along the moving direction of the reagent strip in the detecting slot 16, the second power device drives the measuring head 17 and the hook 37 to move close to or away from the detecting slot 16 in the horizontal direction, the second power device is a second motor 33, and the second motor 33 is mounted on the bearing plate 34. As shown in FIGS. 2 and 5, the movement direction of the hook 37 is the same as the movement direction of the reagent strip in the detection slot 16, and a second timing belt 38 is further provided on the carrier plate 34, and the second timing belt 38 is also provided along the movement direction of the reagent strip in the detection slot 16. The two ends of the second synchronous belt 38 are respectively provided with a third synchronous belt wheel 39, the third synchronous belt wheels 39 are mounted on the bearing plate 34 through a bracket 40, one of the third synchronous belt wheels 39 is in transmission connection with the second motor 33, and the second synchronous belt 38 is driven by the second motor 33 to move along the movement direction of the reagent strip in the detection groove 16. A first guide rail 41 is arranged on the lower side of the second timing belt 38, the first guide rail 41 is fixed on the bearing plate 34, and the first guide rail 41 is arranged in parallel with the timing belt.

As shown in fig. 2 and 7, the hook 37 is connected to the slide table plate 42, the slide table plate 42 is disposed on one side of the second synchronous belt 38 close to the detection groove 16, the slide table plate 42 is fixedly connected with a first slider 43 on one side close to the second synchronous belt 38, the first slider 43 is disposed in cooperation with the first guide rail 41 and slides along the first guide rail 41, the first slider 43 is fixedly connected with the synchronous belt, the second motor 33 transmits power to the second synchronous belt 38, and the second synchronous belt 38 drives the first slider 43 to reciprocate along the movement direction of the reagent strip in the detection groove 16, so as to drive the hook 37 to move.

When the card is fed or discharged, the horizontal height of the hook 37 is higher than the bottom heights of the card slot 8 and the detection slot 16 and lower than the heights of the reagent strip in the card slot 8 and the detection slot 16. The initial position of the hook 37 is located as shown in fig. 2, the card slot 8 is far away from one end of the detection slot 16, the second motor 33 is started, the second synchronous belt 38 drives the hook 37 to move towards the detection slot 16, the hook 37 shifts the reagent strip into the detection slot 16, the reagent strip realizes fine positioning in the detection slot 16 through the elastic sheet 28 and the blocking sheet 29, and card feeding is completed.

As shown in fig. 2 and 7, a third power device for driving the hook 37 to move toward or away from the incubation disc 7 is connected to the slide plate 42, in this embodiment, the third power device is a third motor 46, the third motor 46 is fixed to the slide plate 42, an output end of the third motor 46 is connected to a lead screw 47, a nut seat 48 is sleeved on the lead screw 47, an upper end of the hook 37 is fixedly connected to the nut seat 48, a second guide rail 49 is arranged on the slide plate 42, the second guide rail 49 is arranged in a vertical direction, the nut seat 48 is fixedly connected to a second slider 44 matched with the second guide rail 49, and the hook 37 is fixedly connected to the second slider 44. Thus, the second motor 33 drives the nut seat 48 and the second slide block 44 to move in the vertical direction, and the second slide block 44 drives the hook 37 to reciprocate in the vertical direction.

The reagent strip enters the fixed carrier 15 from the incubation tray 7 and then exits the reagent strip from the fixed carrier 15, and the above-mentioned action function can be completed only by one set of components. When reagent laths are required to enter the fixed carrier 15, one of the lath clamping grooves 8 on the incubation disc 7 is firstly aligned with the bell mouth of the fixed carrier 15, the clamping hook 37 moves to the outer side of the end part of the reagent lath in the incubation disc 7 under the driving of the second motor 33, then the clamping hook 37 descends to the position with the horizontal height between the bottom surface of the clamping groove 8 and the reagent lath under the action of the third motor 46, and the second motor 33 drives the clamping hook 37 to push the reagent lath into the fixed carrier 15. When reagent laths need to be withdrawn from the fixed carrier 15, the hook 37 is moved to the left position of the fixed carrier 15, the hook 37 is lowered to the position of pushing the reagent laths, and the reagent laths are pushed into the lath clamping grooves 8 on the incubation disc 7 from the fixed carrier 15 until being pushed out of the lath clamping grooves 8 on the incubation disc 7 and entering the outlet clamping grooves 8.

Measuring head 17 and trip 37 sharing second motor 33 realize the removal of horizontal direction, and measuring head 17 fixedly connected with third slider 45, third slider 45 fix on second hold-in range 38, and slide along first guide rail 41 with the cooperation of first guide rail 41 and set up, realize first slider 43 and third slider 45's linkage through a second hold-in range 38. As shown in fig. 5, a left optical coupler 50, a middle optical coupler 51 and a right optical coupler 52 are sequentially arranged on the bearing plate 34 along the horizontal direction, and a second optical coupler blocking piece 53 is fixedly connected to the first slider 43 to jointly control the positions of the measuring head 17 and the hook 37 on the first guide rail 41.

As shown in fig. 9 and 11, connection blocks 54 are fixedly mounted on both sides of the notch 13 of the lower case 1, and the connection blocks 54 are fixed to the front cover plate 4 and the lower case 1 by bolts. The connecting block 54 is provided with a bin door cover 55, the bin door cover 55 is fixed on the connecting block 54 through a bolt, in the embodiment, the whole bin door cover 55 is square and corresponds to the notch 13 in shape, and during installation, the bin door cover 55 covers the notch 13. The rear side of the bin gate cover 55 is provided with a card placing platform 56 which is flush with the incubation disc 7, in this embodiment, the rear side is the side close to the incubation disc 7, and the front side is the side far away from the incubation disc 7. As shown in fig. 11, in this embodiment, the surface of the card placing platform 56 is integrally formed in a planar shape, a guide groove 57 is formed in the outer side of the card placing platform 56, the guide groove 57 is communicated with one of the card slots 8 on the incubation tray 7, the guide groove 57 is used for guiding the reagent slats, when the reagent slats are placed, the reagent slats are pushed inwards by the guide groove 57, and the card placing platform 56 supports the reagent slats until the reagent slats are pushed into the card slots 8.

Fixedly connected with correlation mount 58 on door cover 55, be provided with correlation opto-coupler 59 on the correlation mount 58, correlation opto-coupler 59 sets up in door cover 55's both sides, is the vacant region between the correlation opto-coupler 59, does not have the sheltering from of other parts promptly for the staff that detects and place the pick-up plate has or not leaves.

As shown in fig. 8, 9 and 11, a sliding groove 60 is provided along the vertical direction outside the bin gate cover 55, a slidable door blocking piece 61 is provided in the sliding groove 60, when a test card is placed, the door blocking piece 61 slides downwards, the card placing platform 56 is exposed for placing the card, and after the card is placed, the door blocking piece 61 slides upwards to shield the card placing platform 56. The shutter piece 61 main part is platelike, shutter piece 61 lower extreme is connected with the fourth power device of its edge sliding tray 60 up-and-down motion of drive, the fourth power device is fourth motor 62, fourth motor 62 is screw motor, screw motor's output fixedly connected with connection piece 63, connection piece 63 sets up along the horizontal direction, through bolt fixed connection between connection piece 63 and the shutter piece 61, connection piece 63 is connected with guide arm 64, guide arm 64 sets up along the direction of motion of shutter piece 61, guarantee the stability of motion.

As shown in fig. 1, a protective shell 65 is further fixedly connected to the seat plate 11, the protective shell 65 is disposed on the outer side of the door cover 55, a bayonet corresponding to the door stopper piece 61 is disposed on the protective shell 65, the area of the bayonet is not greater than the area of the door cover 55, and the area of the bayonet is not greater than the area of the door stopper piece 61. When the instrument does not work and does work but does not need to insert a reagent plate strip, the shutter piece 61 is in a shielding state, and the internal temperature is ensured; when a reagent plate strip needs to be inserted into the instrument, the shutter piece 61 moves to the lower part of the bin door cover 55, and after the card placing opening on the protective shell 65 is blocked, the risk of mistakenly placing the reagent plate strip is prevented, and the safety of the instrument is ensured; after the instrument received the instruction of inserting the reagent lath, the door keeps off lead screw motor through the below of screw nut drive to door cover 55, the operator sends the reagent lath into the instrument from the bayonet socket of putting of protective housing 65, install a set of correlation opto-coupler 59 on door cover 55's correlation mount 58, be the free region between the correlation opto-coupler 59, whether the hand that is used for responding to operator's sending the reagent lath has left, only when operator's hand that sends the reagent lath leaves the back, keep off door piece 61 and just can shift up to sheltering from the position once more. The reagent strip is fed into the slot 8 of the incubation plate 7 through the guide slot 57 of the door cover 55.

As shown in fig. 9 and 10, a light projector 66 is arranged on the lower shell 1, a corresponding light receiver 67 is arranged on the front cover plate 4, a high-low position reflection optical coupler is further installed on the front cover plate 4 through an optical coupler connecting plate, the light projector 66, the light receiver 67 and the high-low position reflection optical coupler 68 form detection on reagent slats and positions thereof, and it is determined whether reagent slats exist in the card slot 8 of the incubation disc 7, and whether the reagent slats are in place in the slat card slot 8 of the incubation disc 7 is determined.

As shown in fig. 2, a heating film 69 is attached to the bottom plate 2 of the lower case 1 to provide heat to the cavity; a basically closed space is formed by the lower shell 1, the front cover plate 4 and the rear cover plate 5 on the lower shell, the bin door cover 55 positioned at the front part of the lower shell 1 and the protective shell 65, and the temperature stability in the closed space is ensured.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (8)

1. The utility model provides a compact integration multichannel fluorescence immunity quantitative analysis appearance core which characterized in that: including inferior valve and front shroud and the back shroud of setting at the inferior valve upside, have the cavity that is used for detecting between inferior valve, front shroud and the back shroud, be provided with rotatable hatching dish in the cavity, be provided with the draw-in groove that holds the lath on the hatching dish, be provided with the breach that is used for advancing the card on the inferior valve and be used for going out the play card guide slot of card, the direction rotation from the breach to play card guide slot is followed to the hatching dish, the central point that hatches the dish puts and is provided with fixed carrier, the lower contact surface of fixed carrier and reagent lath is in a plane with the bottom surface of the draw-in groove on the hatching dish, be provided with on the fixed carrier and detect the groove, the one end that detects the groove sets up towards going out card guide slot opening, and this end design has the hypotenuse of horn mouth form and dock with hatching dish, the other end design that detects the groove has two separation blades that correspond mutually, two the separation blade is close to one side parallel and level setting that detects the groove, a poking bayonet is arranged between the two blocking pieces, one side of the detection groove is provided with a measuring head and a clamping hook, the measuring head and the clamping hook are arranged side by side along the direction from the detection groove to the clamping guide groove, the measuring head and the clamping hook are connected with a second power device for driving the measuring head and the clamping hook to move along the horizontal direction, the clamping hook is connected with a third power device for driving the measuring head and the clamping hook to reciprocate along the vertical direction, the notch is provided with a bin gate cover, the rear side of the bin gate cover is provided with a card placing platform which is parallel to the incubation disc, the outer side of the card placing platform is provided with a guide groove, the outer side of the bin gate cover is provided with a sliding groove along the vertical direction, a slidable blocking piece is arranged in the sliding groove, the blocking piece is connected with a fourth power device for driving the measuring head to slide along the sliding groove, the outer side of the bin gate cover is provided with a protective shell, and the card placing bayonet corresponding to the blocking piece is arranged on the protective shell, the guide groove is communicated with one clamping groove on the incubation disc.

2. The compact integrated multichannel fluorescence immunoassay quantitative analyzer core according to claim 1, characterized in that: the output end of the second power device is connected with a second synchronous belt, the clamping hook is connected to the sliding table plate, the sliding table plate is arranged on one side, close to the detection groove, of the second synchronous belt, the sliding table plate is fixedly connected with a first sliding block on one side, close to the second synchronous belt, of the sliding table plate, the first sliding block is fixedly connected with the second synchronous belt, the measuring head is fixedly connected with a third sliding block, and the third sliding block is fixed on the second synchronous belt.

3. The compact integrated multichannel fluorescence immunoassay quantitative analyzer core according to claim 2, characterized in that: the output end of the third power device is connected with a screw rod, a nut seat is sleeved on the screw rod, and the upper end of the clamping hook is fixedly connected with the nut seat.

4. The compact integrated multichannel fluorescence immunoassay quantitative analyzer core according to claim 3, characterized in that: the nut seat is fixedly connected with a second sliding block matched with the second guide rail, and the clamping hook is fixedly connected with the second sliding block.

5. The compact integrated multichannel fluorescence immunoassay quantitative analyzer core according to claim 1, characterized in that: incubation dish downside is provided with the layer board, through bolt fixedly connected with central main shaft on the layer board, fixedly connected with cushion on the central main shaft, fixed loader fixed connection is on the cushion, the cushion is provided with high boss and short boss respectively in the both sides of detecting the groove, fixed mounting has the loading board on the last plane of high boss, second power device and second hold-in range are all installed on the loading board.

6. The compact integrated multichannel fluorescence immunoassay quantitative analyzer core according to claim 5, characterized in that: the plate is provided with a first power device for driving the incubation disc to rotate, a first synchronous belt wheel is installed at the output end of the first power device, a second synchronous belt wheel is sleeved on the outer side of the central main shaft through a bearing, a first synchronous belt is sleeved between the first synchronous belt wheel and the second synchronous belt wheel, a rotary main shaft is fixedly connected onto the second synchronous belt wheel through a bolt, and the rotary main shaft is fixedly connected with the incubation disc through a bolt.

7. The compact integrated multichannel fluorescence immunoassay quantitative analyzer core according to claim 1, characterized in that: the bin gate cover is fixedly connected with a correlation fixing frame, correlation optocouplers are arranged on the correlation fixing frame and arranged on two sides of the bin gate cover, and a vacant area is arranged between the correlation optocouplers.

8. The compact integrated multichannel fluoroimmunoassay quantitative analyzer core according to claim 7, characterized in that: the door stopping sheet main body is plate-shaped, the fourth power device is arranged at the lower end of the door stopping sheet, the fourth power device is a fourth motor, the output end of the fourth motor is fixedly connected with a connecting sheet, the connecting sheet is arranged along the horizontal direction, the connecting sheet is fixedly connected with the door stopping sheet through bolts, the connecting sheet is connected with a guide rod, and the guide rod is arranged along the movement direction of the door stopping sheet.

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