CN114042189A - Injection type filler composition and preparation method and application thereof - Google Patents
Injection type filler composition and preparation method and application thereof Download PDFInfo
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- CN114042189A CN114042189A CN202111320547.6A CN202111320547A CN114042189A CN 114042189 A CN114042189 A CN 114042189A CN 202111320547 A CN202111320547 A CN 202111320547A CN 114042189 A CN114042189 A CN 114042189A
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- filler composition
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- lactic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses an injection type filler composition, a preparation method and application thereof. The hyaluronic acid gel in the injection type filler composition has a supporting effect on the volume generated by hyaluronic acid gel, and meanwhile, the poly-L-lactic acid can stimulate the activity of fibroblasts in the skin and stimulate the regeneration of collagen of the body for filling, so that the supporting effect of the filler composition is better improved, and the lasting and stable effect is achieved.
Description
Technical Field
The invention relates to the technical field of beauty treatment, and in particular relates to an injection type filler composition, and a preparation method and application thereof.
Background
With the improvement of living standard, people pay more and more attention to and expect to keep a youthful and beautiful appearance, however, with the increase of age, facial skin begins to age, including skin wrinkles, deep nasolabial folds and the like; these ages are generally treated by injection of a filler. Furthermore, many young people now beautify themselves from the overall structure, also for the purpose of improving the aesthetic appearance, by injecting a filler on the face to reconstruct the facial structure.
Currently, existing dermal fillers generally provide long-term effects by creating volume or by stimulating collagen neogenesis, however, existing fillers are difficult to inject, have poor performance parameters resulting in volume increase, and are less biocompatible and durable.
Disclosure of Invention
The invention aims to provide an injection type filler composition, a preparation method and application thereof.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
the invention provides an injection type filler composition, which comprises hyaluronic acid gel and/or poly-L-lactic acid.
Preferably, the injectable filler composition comprises the following components in parts by volume:
2-4 parts of hyaluronic acid gel and 0.5-1.5 parts of poly-L-lactic acid.
Preferably, the injectable filler composition comprises the following components in parts by volume:
hyaluronic acid gel 3 parts and poly-L-lactic acid 1 part.
The second aspect of the present invention provides a preparation method of the injectable filler composition, wherein the preparation method comprises the following steps:
(a) preparing poly-L-lactic acid into a poly-L-lactic acid solution;
(b) adding hyaluronic acid gel into the poly-L-lactic acid solution and uniformly mixing to obtain the injection filler composition.
Preferably, the poly-L-lactic acid solution is a poly-L-lactic acid aqueous solution.
Preferably, the concentration of the poly-L-lactic acid solution is 35-75%.
Preferably, the hyaluronic acid gel may be hyaluronic acid gel of plain ripple brand.
In a third aspect, the present invention provides a use of the injectable filler composition described above for facial contour reconstruction.
In a fourth aspect, the present invention provides a method for reconstructing a facial contour, the method comprising injecting the injectable filler composition described above into the facial bony structure high points.
Compared with the prior art, the invention has the beneficial effects that at least:
the hyaluronic acid gel in the injection type filler composition plays roles in nourishing, regenerating and supporting, meanwhile, the poly-L-lactic acid can stimulate the activity of fibroblasts in skin and stimulate the regeneration of collagen of a human body for filling, and plays a role in assisting and strengthening, so that the supporting effect of the filler composition is better improved, the lasting and stable effect is achieved, and the hyaluronic acid gel is injected into high points of a facial bony structure to form high point reconstruction and present visual cohesion from the structure; in addition, the filler composition disclosed by the invention can effectively improve the elastic modulus of the composition injected into dermis by reasonably proportioning all the components, and ensures the stability of the filling volume.
Detailed Description
The following describes embodiments of the present invention in detail with reference to the following embodiments. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.
The raw materials used in the following examples are as follows:
hyaluronic acid gel: suwenyu hyaluronic acid gel.
Example 1
Injection type filler composition
The injection type filler composition comprises the following components in parts by volume:
4 parts of hyaluronic acid gel and 1.5 parts of poly-L-lactic acid.
Second, preparation method
The preparation method of the injection type filler composition comprises the following steps:
(a) preparing poly-L-lactic acid into a poly-L-lactic acid aqueous solution with the concentration of 50 percent;
(b) adding hyaluronic acid gel into the poly-L-lactic acid solution according to the volume parts, and uniformly mixing to obtain the injection filler composition.
Example 2
Injection type filler composition
The injection type filler composition comprises the following components in parts by volume:
hyaluronic acid gel 2 parts and poly-L-lactic acid 0.5 parts.
Second, preparation method
The preparation method of the injection type filler composition comprises the following steps:
(a) preparing poly-L-lactic acid into a poly-L-lactic acid aqueous solution with the concentration of 50 percent;
(b) adding hyaluronic acid gel into the poly-L-lactic acid solution according to the volume parts, and uniformly mixing to obtain the injection filler composition.
Example 3
Injection type filler composition
The injection type filler composition comprises the following components in parts by volume:
hyaluronic acid gel 3 parts and poly-L-lactic acid 1 part.
Second, preparation method
The preparation method of the injection type filler composition comprises the following steps:
(a) preparing poly-L-lactic acid into a poly-L-lactic acid aqueous solution with the concentration of 50 percent;
(b) adding hyaluronic acid gel into the poly-L-lactic acid solution according to the volume parts, and uniformly mixing to obtain the injection filler composition.
Example 4
Injection type filler composition
The injection type filler composition comprises the following components in parts by volume:
hyaluronic acid gel 3 parts and poly-L-lactic acid 1 part.
Second, preparation method
The preparation method of the injection type filler composition comprises the following steps:
(a) preparing a poly-L-lactic acid aqueous solution with the concentration of 30 percent;
(b) adding hyaluronic acid gel into the poly-L-lactic acid solution according to the volume parts, and uniformly mixing to obtain the injection filler composition.
Example 5
Injection type filler composition
The injection type filler composition comprises the following components in parts by volume:
hyaluronic acid gel 3 parts and poly-L-lactic acid 1 part.
Second, preparation method
The preparation method of the injection type filler composition comprises the following steps:
(a) preparing the poly-L-lactic acid into a poly-L-lactic acid aqueous solution with the concentration of 60 percent;
(b) adding hyaluronic acid gel into the poly-L-lactic acid solution according to the volume parts, and uniformly mixing to obtain the injection filler composition.
Examples of the experiments
Injection-type filler compositions were obtained in the same manner as in examples 1 to 3;
purchasing female Kunming mice, the same batch and the same size are randomly divided into 3 groups, each group comprises 5 mice, the back of the 1 st group of mice is injected with 2ml of the injection-type filler composition of the example 1 subcutaneously, and the back of the 2 nd group of mice is injected with 2ml of the injection-type filler composition of the example 2 subcutaneously; group 3 mice were injected subcutaneously in the back with 2ml of the injectable bulking agent composition of example 3; injecting the same position and managing completely the same for each mouse, taking out the injection behind each mouse after injecting for 20 days, calculating the volume, calculating the average value of the injection taken out of each group, and the calculation result is shown in table 1;
TABLE 1
| Group of | Volume (cm)3) |
| Group 1 | 0.05 |
| Group 2 | 0.07 |
| Group 3 | 0.12 |
As can be seen from table 1, it is,
the injection type filler composition prepared by the embodiment of the invention can play a supporting role and has the stability of filling volume.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.
Claims (8)
1. An injectable filler composition, which is characterized by comprising hyaluronic acid gel and/or poly-L-lactic acid.
2. An injectable filler composition according to claim 1, wherein the injectable filler composition comprises the following components in parts by volume:
2-4 parts of hyaluronic acid gel and 0.5-1.5 parts of poly-L-lactic acid.
3. An injectable filler composition according to claim 1 or 2, wherein the injectable filler composition comprises the following components in parts by volume:
hyaluronic acid gel 3 parts and poly-L-lactic acid 1 part.
4. A process for preparing an injectable filler composition according to any of claims 1 to 3, comprising the steps of:
(a) preparing poly-L-lactic acid into a poly-L-lactic acid solution;
(b) adding hyaluronic acid gel into the poly-L-lactic acid solution and uniformly mixing to obtain the injection filler composition.
5. The method according to claim 4, wherein the poly-L-lactic acid solution is an aqueous poly-L-lactic acid solution.
6. The method according to claim 4, wherein the concentration of the poly-L-lactic acid solution is 35-75%.
7. Use of an injectable filler composition according to any of claims 1 to 3 for the reconstruction of facial contours.
8. A method for reconstructing a facial contour, comprising injecting the injectable filler composition according to any one of claims 1 to 3 into a facial bony structure high point.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111320547.6A CN114042189A (en) | 2021-11-09 | 2021-11-09 | Injection type filler composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111320547.6A CN114042189A (en) | 2021-11-09 | 2021-11-09 | Injection type filler composition and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114042189A true CN114042189A (en) | 2022-02-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111320547.6A Pending CN114042189A (en) | 2021-11-09 | 2021-11-09 | Injection type filler composition and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115414530A (en) * | 2022-10-24 | 2022-12-02 | 深圳市致美生物科技有限公司 | Injectable filler for accelerating collagen regeneration induction and preparation and application thereof |
Citations (7)
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| WO2011081253A1 (en) * | 2009-12-28 | 2011-07-07 | 한남대학교 산학협력단 | Injectable porous microparticle filler system |
| US20110172180A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| WO2012004142A1 (en) * | 2010-07-09 | 2012-01-12 | Merz Pharma Gmbh & Co. Kgaa | Alginate filler including eukaryotic cells |
| CN103834053A (en) * | 2014-02-28 | 2014-06-04 | 陕西佰傲再生医学有限公司 | Injectable crosslinked hyaluronic acid gel and preparation method thereof |
| CN109331224A (en) * | 2018-09-21 | 2019-02-15 | 陈炯锋 | A kind of gel and its preparation method and application |
| CN110559489A (en) * | 2019-09-25 | 2019-12-13 | 广州益诚生物科技有限公司 | Injection filler |
| CN111840641A (en) * | 2020-08-31 | 2020-10-30 | 陈玉芝 | Poly-L-lactic acid filler and preparation method and application thereof |
-
2021
- 2021-11-09 CN CN202111320547.6A patent/CN114042189A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2011081253A1 (en) * | 2009-12-28 | 2011-07-07 | 한남대학교 산학협력단 | Injectable porous microparticle filler system |
| US20110172180A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| WO2012004142A1 (en) * | 2010-07-09 | 2012-01-12 | Merz Pharma Gmbh & Co. Kgaa | Alginate filler including eukaryotic cells |
| CN103834053A (en) * | 2014-02-28 | 2014-06-04 | 陕西佰傲再生医学有限公司 | Injectable crosslinked hyaluronic acid gel and preparation method thereof |
| CN109331224A (en) * | 2018-09-21 | 2019-02-15 | 陈炯锋 | A kind of gel and its preparation method and application |
| CN110559489A (en) * | 2019-09-25 | 2019-12-13 | 广州益诚生物科技有限公司 | Injection filler |
| CN111840641A (en) * | 2020-08-31 | 2020-10-30 | 陈玉芝 | Poly-L-lactic acid filler and preparation method and application thereof |
Non-Patent Citations (1)
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| 李红梅等: "注射用聚乳酸和交联透明质酸钠凝胶的制备及性能研究", 《生物医学工程研究》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115414530A (en) * | 2022-10-24 | 2022-12-02 | 深圳市致美生物科技有限公司 | Injectable filler for accelerating collagen regeneration induction and preparation and application thereof |
| CN115414530B (en) * | 2022-10-24 | 2024-01-12 | 广西小分子医疗科技有限公司 | Injectable filler for accelerating induced collagen regeneration and preparation and application thereof |
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Application publication date: 20220215 |