CN1140281C - Yiyuansan powder as one orally taken medicine for treating liver cancer and its preparation - Google Patents
Yiyuansan powder as one orally taken medicine for treating liver cancer and its preparation Download PDFInfo
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Abstract
The present invention relates to an oral taking medicine for treating a liver cancer named as Yiyuansan powder and a preparing method. The Yiyuansan powder is formed by refining astragalus root, pseudostellaria root, felicitous plant glossy ganoderma, aweto, a turtle shell, fructus psoralea, homalomena rhizoma, eucommia bark, cibot rhizome, radix salviae miltiorrhizae, notoginseng, agrimony, pangolin, a hedgehog skin, a crab claw, a cockroach, snow lotuse, oldenlandia diffusa, honeysuckle flowers, houttuynia, herba violae, ledebouriella roots and antelope's horn tips. The medicine is used for treating diseases of a liver cancer and has the advantages of quick curative effect, short treating period, high curative effect, pure Chinese medicine preparation, no side effect, convenient use, low medicine price, etc.
Description
The present invention relates to a kind of oral drugs for the treatment of cancer, particularly relate to a kind of oral drugs and manufacture method thereof for the treatment of hepatocarcinoma.
Hepatocarcinoma is a kind of intractable internal medicine disease, commonplace, it is wide to distribute, sickness rate is on the rise in recent years, and according to the incomplete statistics of the relevant health organ in the world, the whole world has 9,000,000 people to suffer from cancer every year at present, there are every year 5000000 people to die from cancer, being the difficult pertinacious disease of a kind of internal medicine of generally acknowledging both at home and abroad, is the obstinate disease of threat to life maximum in the world today, causes very big threat to the human life.Though it is a lot of to treat this sick method and medicine now, majority is a western medicine therapy, but can not reach the curative effect of people's anticipation, for example: generally adopt " chemotherapy " Therapeutic Method, weak curative effect not only, also have feel sick, untoward reaction and side effect shortcomings such as diet minimizing, alopecia.
The objective of the invention is in order to overcome above-mentioned weak point, provide a kind of through the inventor study intensively for many years make with long-term clinical practice have instant effect, the treatment phase is short, effective percentage is high and cure rate is high, easy to use, the oral drugs Yi Yuan San Powder Beneficial to Vitality and the manufacture method thereof of the treatment hepatocarcinoma that has no side effect.
The invention provides the following column weight amount of the oral drugs Yi Yuan San Powder Beneficial to Vitality proportion raw material of treatment hepatocarcinoma, through pulverizing, extract, concentrate, dry, the allotment form oral drugs: Radix Astragali 18-30 part Radix Pseudostellariae 15-30 part Ganoderma lucidum seu Japonicum 6-15 part Cordyceps 3-8 part Carapax Trionycis 15-30 part Fructus Psoraleae 16-30 part Rhizoma Homalomenae 16-29 part Cortex Eucommiae 16-30 part Rhizoma Cibotii 15-29 part Radix Salviae Miltiorrhizae 16-28 part Radix Notoginseng 6-15 part Herba Agrimoniae 6-15 part Squama Manis pearl 2-8 part Corium Erinacei Seu Hemiechianus 6-15 part Ungula Eriocheir sinensis 6-14 part Eupolyphaga Seu Steleophaga 6-15 part Herba Saussureae Involueratae 2-8 part Herba Hedyotidis Diffusae 13-30 part Flos Lonicerae 13-30 part Herba Houttuyniae 16-29 part Herba Violae 15-29 part Radix Saposhnikoviae 6-15 part Saigae Tataricae the top of the horn 2-8 part.
In the oral drugs Yi Yuan San Powder Beneficial to Vitality of controlling liver cancer provided by the invention, described raw material weight proportion optimization is: give birth to the windproof 8-13 part of Radix Astragali 19-25 part radix pseudostellariae 17-25 part polyporus lucidus 8-13 part Cordyceps sinensis 4-6 part turtle shell 17-23 part Psoralea corylifolia 18-25 part rhizoma homalonemae 19-25 part bark of eucommia 18-25 part rhizoma cibotii 17-24 part radix salviae miltiorrhizae 17-26 part pseudo-ginseng 7-13 part hairyvein agrimony 7-12 part pangolin (pearl) 3-6 part hedgehog skin 8-13 part crab claw 8-12 part ground bettle 8-13 part saussurea involucrata 3-6 part oldenlandia diffusa 17-26 part honeysuckle 16-23 part cordate houttuynia 17-23 part Chinese violet 18-23 part antelope the top of the horn 3-6 part.
During the oral drugs benefit unit of Hepatoma therapy provided by the invention loose, described raw material weight proportioning was: give birth to 5 parts of 20 parts of windproof 10 parts of antelope the top of the horns of 20 portions of glossy ganoderma grass 20 portions of Chinese violets of 20 portions of cordate houttuynias of 20 portions of honeysuckles of 5 parts of oldenlandia diffusas of 10 portions of saussurea involucrata of 10 portions of ground bettles of 10 parts of crab claws of 5 portions of hedgehog skins of 10 parts of pangolin pearls of 10 portions of hairyvein agrimonies of 20 portions of pseudo-ginseng of 20 parts of radix salviae miltiorrhizaes of 20 parts of rhizoma cibotii of 20 parts of barks of eucommia of 20 parts of rhizoma homalonemaes of 20 parts of Psoralea corylifolias of 5 parts of turtle shells of 10 parts of Cordyceps sinensis of 20 parts of radix pseudostellariaes of the Radix Astragali.
In the oral drugs Yi Yuan San Powder Beneficial to Vitality according to treatment hepatocarcinoma provided by the invention:
Radix Astragali, Radix Pseudostellariae, Ganoderma lucidum seu Japonicum, Cordyceps, Carapax Trionycis are monarch drug, are used for tonification unit to set upright.
Fructus Psoraleae, Rhizoma Homalomenae, the Cortex Eucommiae, Rhizoma Cibotii are ministerial drug, are used for the auxiliary monarch drug of physique enhancing and bone strengthening and set upright.
Radix Salviae Miltiorrhizae, Radix Notoginseng, Herba Agrimoniae are used for blood circulation promoting and blood stasis dispelling, and dredge the meridian passage changes microcirculation.Squama Manis pearl, Corium Erinacei Seu Hemiechianus, Ungula Eriocheir sinensis, Eupolyphaga Seu Steleophaga are used for resolving the hard mass.Above-mentioned seven flavor medicine agent all is an adjuvant drug.
Herba Saussureae Involueratae, Flos Lonicerae, Herba Houttuyniae, Herba Hedyotidis Diffusae, Herba Violae are used for heat-clearing and toxic substances removing.Radix Saposhnikoviae, Saigae Tataricae the top of the horn are apt to away whole body, draw all medicines and arrive focus.Described seven flavor medicine agent all is a messenger drug.
Said medicine monarch drug, ministerial drug, adjuvant drug, the full side's compatibility of messenger drug, mutual coordinated has nourishing Yuanyang, invigorating function of kidney and strengthening bone, keeps fit strong marrow, removing food stagnancy and assault fortified position, and removes and dislikes tissue regeneration promoting, the eliminating evil effect that lengthens one's life; Improve blood circulation, promote the metabolism of liver, strengthened new regenerative cell's growth function; Thereby improve the effective percentage and the cure rate of treatment hepatocarcinoma.
The manufacture method of the oral drugs of treatment hepatocarcinoma provided by the invention comprises the following steps:
(1) pulverize pulvis tenuis:
With Cordyceps, Squama Manis pearl, Saigae Tataricae the top of the horn, Herba Saussureae Involueratae, by described weight proportion, under the sterile working, be ground into impalpable powder with pulverizer, it is standby to reinstall in the container after the sterilization sealing.
(2) extract aqueous extract:
With Radix Astragali, Radix Pseudostellariae, Carapax Trionycis, Fructus Psoraleae, Rhizoma Homalomenae, the Cortex Eucommiae, Rhizoma Cibotii, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, Flos Lonicerae, Herba Houttuyniae, Herba Violae, Radix Notoginseng, Herba Agrimoniae, Corium Erinacei Seu Hemiechianus, Ungula Eriocheir sinensis, Eupolyphaga Seu Steleophaga, Radix Saposhnikoviae, Ganoderma lucidum seu Japonicum, put into the Chinese medicine extraction jar by described weight proportion and appropriate amount of purified water, use the water extraction aqueous extract.
(3) concentrate:
The aqueous extract that above-mentioned steps 2 is obtained refines method routinely with the normal pressure concentration tank, refines into the Chinese medicine unguentum.
(4) spray drying:
The Chinese medicine unguentum that above-mentioned steps 3 is obtained is spray dried to the meticulous powder of Chinese medicine with spray drying device;
(5) allotment:
The Chinese medicine impalpable powder that meticulous powder of Chinese medicine that above-mentioned steps 3 is obtained and above-mentioned steps 1 obtain is put into blender together with two kinds of fine powders under gnotobasis, stir, and becomes the oral drugs finished powder.
(6) fill capsule:
Under gnotobasis, dress up 0.5 gram/capsules as the oral drugs finished powder that above-mentioned steps 5 need be obtained, with the plastic bottle capsule sealing of packing into the fill capsule device.
In the oral administration methods according to manufacturing treatment hepatocarcinoma provided by the invention, Chinese medicine extraction jar and extracting method are commercially available public in the described step (2).Described appropriate amount of purified water consumption does not have strict the qualification, usually medicine submergence adding can be as the criterion, should not be too much or very little, consider thoroughly active ingredient to be extracted and not increase for a long time and be advisable to concentration step, for example be generally 3 times that drop into each raw material medicament total weight parts, be 1: 3 (weight).All there is explanation extraction time when using described Chinese medicine extraction jar.Normal pressure concentration tank, spray drying device and fill capsule device all are commercially available equipment known in the art described in described step (3), (4) and (6), its working procedure also is regulation, known conventional method, is generally 2-4 weight portion (dropping into raw material medicament total weight parts meter) through the meticulous powder of Chinese medicine that obtains after the spray drying.
In the manufacture method according to the oral drugs of treatment hepatocarcinoma provided by the invention, the oral drugs finished powder by step 5 obtains can directly be used as oral drugs, for the ease of oral, can be made into various forms of oral drugs,, be preferably the capsule oral medicament as tablet, granule and capsule etc.
The oral drugs of treatment hepatocarcinoma provided by the invention adapt to various types of oncosises and cancer, particularly liver cancer patient in use.
Consumption:
(1) the prevention oral dose was obeyed once on the 3rd, each gram.
(2) the initial stage patient obeyed three times on the 1st, obeyed three grams at every turn.
(3) severe patient was obeyed six times on the 1st, obeyed six grams at every turn.
The present invention will further specify the present invention with the following example, but protection scope of the present invention is not limited to the embodiment of the invention, and those of ordinary skill is changed prescription of the present invention and method in the art, still in protection domain of the present invention.
Embodiment 1
With Cordyceps, Squama Manis pearl, Saigae Tataricae the top of the horn, Herba Saussureae Involueratae, be ground into 20 kilograms of impalpable powders with pulverizer by weight in the table 1.
With Radix Astragali, Radix Pseudostellariae, Ganoderma lucidum seu Japonicum, Carapax Trionycis, Fructus Psoraleae, Rhizoma Homalomenae, the Cortex Eucommiae, Rhizoma Cibotii, Radix Salviae Miltiorrhizae, Radix Notoginseng, Herba Agrimoniae, Ungula Eriocheir sinensis, Corium Erinacei Seu Hemiechianus, Eupolyphaga Seu Steleophaga, Herba Hedyotidis Diffusae, Flos Lonicerae, Herba Houttuyniae, Herba Violae, Radix Saposhnikoviae, put into the Chinese medicine extraction jar by weight in the table 1 and 930 kilograms of pure water, with water extraction extract aqueous extract, with the aqueous extract that obtains, in the normal pressure concentration tank, be condensed into thickness Chinese medicine unguentum then.The reuse spray drying device, the above-mentioned Chinese medicine unguentum of spray drying gets 12.4 kilograms in the meticulous powder of Chinese medicine.
20 kilograms of above-mentioned impalpable powders that obtains and 12.4 kilograms in the meticulous powder of the above-mentioned Chinese medicine that obtains are put into blender together stir well and spare into 32.4 kilograms of finished powder, and then dress up 0.5 gram/capsules with the fill capsule device.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| Cordyceps (kilogram) | 5 | 3 | 7 |
| Herba Saussureae Involueratae (kilogram) | 5 | 3.5 | 7.5 |
| Squama Manis strain (kilogram) | 5 | 4 | 7.5 |
| Saigae Tataricae the top of the horn (kilogram) | 5 | 3.5 | 6 |
| Radix Astragali (kilogram) | 20 | 18 | 30 |
| Radix Pseudostellariae (kilogram) | 20 | 17 | 30 |
| Carapax Trionycis (kilogram) | 20 | 15 | 28 |
| Fructus Psoraleae (kilogram) | 20 | 17 | 28 |
| Rhizoma Homalomenae (kilogram) | 20 | 16 | 26 |
| The Cortex Eucommiae (kilogram) | 20 | 17 | 26 |
| Rhizoma Cibotii (kilogram) | 20 | 16 | 24 |
| Radix Salviae Miltiorrhizae (kilogram) | 20 | 16 | 24 |
| Herba Hedyotidis Diffusae (kilogram) | 20 | 17 | 25 |
| Flos Lonicerae (kilogram) | 20 | 17 | 25 |
| Herba Houttuyniae (kilogram) | 20 | 16 | 23 |
| Herba Violae (kilogram) | 20 | 15 | 23 |
| Radix Notoginseng (kilogram) | 10 | 6 | 15 |
| Herba Agrimoniae (kilogram) | 10 | 6 | 15 |
| Corium Erinacei Seu Hemiechianus (kilogram) | 10 | 6 | 14 |
| Ungula Eriocheir sinensis (kilogram) | 10 | 7 | 14 |
| Eupolyphaga Seu Steleophaga (kilogram) | 10 | 8 | 13 |
| Radix Saposhnikoviae (kilogram) | 10 | 6 | 13 |
| Ganoderma lucidum seu Japonicum (kilogram) | 10 | 8 | 12 |
| Pure water (kilogram) | 930 | 770 | 1224 |
Embodiment 2
Embodiment 2 manufacturing steps are identical with the step of embodiment 1, and different is that its consumption is shown in (embodiment 2) in the table 1.The finished powder that wherein obtains is 24.77 kilograms.
Embodiment 3
Embodiment 3 manufacturing steps are identical with the step of embodiment 1, and different is that its consumption is shown in (embodiment 3) in the table 1.The finished powder that wherein obtains is 44.32 kilograms.
The oral drugs advantage that the present invention treats hepatocarcinoma is:
1, instant effect: general patient takes after 15 days and can take effect.
2, the treatment phase is short: can cure in general patient 6-9 month, cure in small number of patients 1-2 month.
3, effective percentage height and non-relapse after healing effective percentage are about 79%, and cure rate is about 30%.
4, pure Chinese medicinal preparation has no side effect through clinical observation for many years.
5, because the refinement dosage is few, taking convenience, the medicine valency is cheap, and the practical value height is subjected to the patient deeply
Welcome.
Adopt the clinical observation result of oral drug capsule curative effect of treatment hepatocarcinoma provided by the invention as follows:
From year June in March, 1998-2000, the 62 routine clinical observations of the used oral drugs Yi Yuan San Powder Beneficial to Vitality treatment liver cancer patient of the present invention of the whole nation the 69 training disease research are as follows:
Handled to draw in 62 examples mean treatment natural law 270.49 days by statistics by last table data, effective percentage is 79 ± 2.33, and cure rate is 30.6 ± 4.66.
The efficacy assessment standard of medicine of the present invention in the table (with reference to " the new Chinese medicine clinical research guideline " of Ministry of Public Health formulation in 1993) is as follows:
(1) symptom that takes effect in medication 7-15 days take a favorable turn and claims to take effect.
(2) effectively transference cure 36-69% is called effectively.
(3) produce effects transference cure 70-94% is called produce effects.
(4) cure symptom all disappear (or disappearing more than 95%) be called healing.
(5) invalid transference cure 36% is hereinafter referred to as invalid.
From year June in March, 1998-2000,69 trainings sick institute in the whole nation uses " doctor trained in Western medicine amic therapy method " and oral drugs Yi Yuan San Powder Beneficial to Vitality of the present invention to treat liver cancer patient respectively, and it is as follows to carry out two groups of case observation of curative effect results:
Two groups of data are compared analysis:
Treatment is organized in 21 cases, male's 19 examples, and women's 2 examples, 45.3 years old mean age, condition of illness is mid-term before seeking medical advice, mean treatment natural law 276.8 days, phenomenon has no adverse reaction during the treatment.Effective percentage is 80.95%, and cure rate is 33.3%, in matched group 21 cases, and male's 19 examples, women's 2 examples, 45.1 years old mean age, condition of illness is mid-term before going to a doctor, mean treatment natural law 398.6 days.Untoward reaction number 13 people are arranged during the treatment, and effective percentage is 61.9%, and cure rate is 19.04%.
According to male, women, the mean age before above two groups of treatments, disease symptom, these four analyses, difference does not have the significance meaning between two groups, and it is more reasonable to illustrate that grouping is controlled in this examination, and equilibrium has neat same comparability.
Two groups of data contrast efficacy analysis:
The effective percentage of treatment group, cure rate is apparently higher than matched group.Two group differences all have the significance meaning, and clinical observation shows:
1. treatment group has 9 cases to take medicine after 15 days, and patient's diet increases, and matched group does not have this effect.
2. treatment group effective percentage is higher than matched group 19.05.
3. treatment group cure rate is higher than matched group 14.26.
4. there are 13 cases during " chemotherapy ", to occur feeling sick in the matched group, anorexia, diet reduces bad
Reaction.Also have minority the untoward reaction of medicine erythra to occur.The treatment group does not have this phenomenon.
5. treatment group mean treatment natural law was lower than matched group 121.8 days.
The medical expense of 6. treatment group is starkly lower than matched group.
Claims (7)
1, a kind of oral drugs for the treatment of hepatocarcinoma, it is characterized in that: it is following column weight amount proportion raw material, through pulverizing, water extraction, concentrate, drying, allotment and the oral drugs made: Radix Astragali 18-30 part Radix Pseudostellariae 15-30 part Ganoderma lucidum seu Japonicum 6-15 part Cordyceps 3-8 part Carapax Trionycis 15-30 part Fructus Psoraleae 16-30 part Rhizoma Homalomenae 16-29 part Cortex Eucommiae 16-30 part Rhizoma Cibotii 15-29 part Radix Salviae Miltiorrhizae 16-28 part Radix Notoginseng 6-15 part Herba Agrimoniae 6-15 part Squama Manis pearl 2-8 part Corium Erinacei Seu Hemiechianus 6-15 part Ungula Eriocheir sinensis 6-14 part Eupolyphaga Seu Steleophaga 6-15 part Herba Saussureae Involueratae 2-8 part Herba Hedyotidis Diffusae 13-30 part Flos Lonicerae 13-30 part Herba Houttuyniae 16-29 part Herba Violae 15-29 part Radix Saposhnikoviae 6-15 part Saigae Tataricae the top of the horn 2-8 part.
2, according to claim 1 the oral drugs of Hepatoma therapy is characterized in that described raw material weight proportioning is: give birth to the windproof 8-13 part of Radix Astragali 19-25 part radix pseudostellariae 17-25 part polyporus lucidus 8-13 part Cordyceps sinensis 4-6 part turtle shell 17-23 part Psoralea corylifolia 18-25 part rhizoma homalonemae 19-25 part bark of eucommia 18-25 part rhizoma cibotii 17-24 part radix salviae miltiorrhizae 17-26 part pseudo-ginseng 7-13 part hairyvein agrimony 7-12 part pangolin pearl 3-6 part hedgehog skin 8-13 part crab claw 8-12 part ground bettle 8-13 part saussurea involucrata 3-6 part oldenlandia diffusa 17-26 part honeysuckle 16-23 part cordate houttuynia 17-23 part Chinese violet 18-23 part antelope the top of the horn 3-6 part.
3, according to the oral drugs of the Hepatoma therapy of claim 1, it is characterized in that described raw material weight proportioning is: give birth to 5 parts of 20 parts of windproof 10 parts of antelope the top of the horns of 20 portions of glossy ganodermas grass 20 portions of Chinese violets of 20 portions of cordate houttuynias of 20 portions of honeysuckles of 5 parts of oldenlandia diffusas of 10 portions of saussurea involucrata of 10 portions of ground bettles of 10 parts of crab claws of 5 portions of hedgehog skins of 10 parts of pangolin pearls of 10 portions of hairyvein agrimonies of 20 portions of pseudo-ginseng of 20 parts of radix salviae miltiorrhizaes of 20 parts of rhizoma cibotii of 20 parts of barks of eucommia of 20 parts of rhizoma homalonemaes of 20 parts of Psoralea corylifolias of 5 parts of turtle shells of 10 parts of Cordyceps sinensis of 20 parts of radix pseudostellariaes of the Radix Astragali.
4, according to each the oral drugs of treatment hepatocarcinoma of claim 1-3, it is characterized in that described oral drugs are tablet, granule or capsule.
5, a kind of manufacture method as the oral drugs of arbitrary described treatment hepatocarcinoma among the claim 1-3 comprises the following steps:
(1) with the Cordyceps, Squama Manis pearl, Saigae Tataricae the top of the horn, the Herba Saussureae Involueratae that weigh up, with being ground into impalpable powder, sealing is standby in the container after the sterilization of packing under the sterile working;
(2) with the Radix Astragali, Radix Pseudostellariae, Carapax Trionycis, Fructus Psoraleae, Rhizoma Homalomenae, the Cortex Eucommiae, Rhizoma Cibotii, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, Flos Lonicerae, Herba Houttuyniae, Herba Violae, Radix Notoginseng, Herba Agrimoniae, Corium Erinacei Seu Hemiechianus, Ungula Eriocheir sinensis, Eupolyphaga Seu Steleophaga, Radix Saposhnikoviae, the Ganoderma lucidum seu Japonicum that weigh up, put into the Chinese medicine extraction jar with pure water, propose aqueous extract with water extraction;
(3) aqueous extract that above-mentioned steps (2) is obtained refines method routinely with the normal pressure concentration tank, refines into the Chinese medicine unguentum;
(4) the Chinese medicine unguentum that above-mentioned steps (3) is obtained is spray dried to the meticulous powder of Chinese medicine;
(5) the Chinese medicine impalpable powder that obtains of meticulous powder of Chinese medicine that above-mentioned steps (3) is obtained and above-mentioned steps 1 is put into blender together with two kinds of fine powders under gnotobasis, stirs, and becomes the oral drugs finished powder.
6, a kind of manufacture method of the oral drugs as the arbitrary described treatment hepatocarcinoma of claim 1-3 comprises the following steps:
(1) with the Cordyceps, Squama Manis pearl, Saigae Tataricae the top of the horn, the Herba Saussureae Involueratae that weigh up, be ground into impalpable powder under the sterile working, sealing is standby in the container after the sterilization of packing into;
(2) with the Radix Astragali, Radix Pseudostellariae, Carapax Trionycis, Fructus Psoraleae, Rhizoma Homalomenae, the Cortex Eucommiae, Rhizoma Cibotii, Radix Salviae Miltiorrhizae, Herba Hedyotidis Diffusae, Flos Lonicerae, Herba Houttuyniae, Herba Violae, Radix Notoginseng, Herba Agrimoniae, Corium Erinacei Seu Hemiechianus, Ungula Eriocheir sinensis, Eupolyphaga Seu Steleophaga, Radix Saposhnikoviae, the Ganoderma lucidum seu Japonicum that weigh up, put into the Chinese medicine extraction jar with pure water, propose aqueous extract with water extraction;
(3) aqueous extract that above-mentioned steps (2) is obtained refines method routinely with the normal pressure concentration tank, refines into the Chinese medicine unguentum;
(4) the Chinese medicine unguentum that above-mentioned steps (3) is obtained is spray dried to the meticulous powder of Chinese medicine;
(5) the Chinese medicine impalpable powder that obtains of meticulous powder of Chinese medicine that above-mentioned steps (3) is obtained and above-mentioned steps 1 is put into blender together with two kinds of fine powders under gnotobasis, stirs, and becomes the oral drugs finished powder;
(6) finished powder that above-mentioned steps (5) is obtained is used the fill capsule device under gnotobasis, dresses up 0.5 gram/capsules, with pack into capsule sealing of plastic bottle.
7,, it is characterized in that described pure water is 3 times by the medicament stock total weight parts according to each the manufacture method of claim 5-6.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011040017A CN1140281C (en) | 2001-02-14 | 2001-02-14 | Yiyuansan powder as one orally taken medicine for treating liver cancer and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011040017A CN1140281C (en) | 2001-02-14 | 2001-02-14 | Yiyuansan powder as one orally taken medicine for treating liver cancer and its preparation |
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| CN1309999A CN1309999A (en) | 2001-08-29 |
| CN1140281C true CN1140281C (en) | 2004-03-03 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943648B (en) * | 2006-10-18 | 2012-03-07 | 赵正福 | A plant medicine for treatment of primary hepatic carcinoma and its preparation method and use |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138181A (en) * | 2016-08-31 | 2016-11-23 | 赖建平 | A kind of treat liver cirrhosis and hepatocarcinoma is postoperative or hepatic metastases suppression tumor Chinese medicine formula |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943648B (en) * | 2006-10-18 | 2012-03-07 | 赵正福 | A plant medicine for treatment of primary hepatic carcinoma and its preparation method and use |
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| CN1309999A (en) | 2001-08-29 |
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