CN114027505A - 一种用于口腔内含服的泡腾片 - Google Patents
一种用于口腔内含服的泡腾片 Download PDFInfo
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- CN114027505A CN114027505A CN202111323219.1A CN202111323219A CN114027505A CN 114027505 A CN114027505 A CN 114027505A CN 202111323219 A CN202111323219 A CN 202111323219A CN 114027505 A CN114027505 A CN 114027505A
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- oral cavity
- effervescent tablet
- effervescent
- powder
- lactobacillus
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Abstract
本发明涉及一种用于口腔内含服的泡腾片，包含益生菌和泡腾崩解剂。所述泡腾片用于使口气清新。
Description
技术领域
本发明涉及口腔健康食品技术领域，特别是涉及一种用于口腔内含服的泡腾片。
背景技术
益生菌是指活的，当摄入足够数量时，对宿主健康起有益作用的微生物。已证实益生菌的核心功能是改善人体胃肠道健康，如平衡肠道群、缓解肠道炎症、缓解肠易激综合征等。近年来，益生菌的其它功能也被越来越多地研究及证实，如女性泌尿道健康、代谢健康、体重管理、情绪健康、口腔健康等。一些益生菌菌株被发现可以抑制口腔变形链球菌，预防龋齿，对口腔健康有益。但常规的益生菌对外界环境因素比较敏感，温度、水分、机械力、环境酸碱度等，都会影响到益生菌的存活，从而影响其功效的发挥。
口腔泡腾片是在泡腾片剂型基础上的升级转化，借鉴了泡腾片利用有机酸和碱式碳酸(氢)盐作为泡腾崩解剂，置于水中发生泡腾反应，生成并释放大量的二氧化碳气体的原理，同时克服泡腾片需要溶解于水中食用的不便利性。
现有技术中的口气清新产品，大多采用遮蔽剂或香精掩饰的方式，并未真正起到降低口臭气体成分的作用。有些含有抑菌成分的漱口水仅具有清除口腔食物残渣，抑菌消毒的作用，完全无法降低口腔中挥发性硫化物的含量；同时，其在抑制有害菌的同时，也对有益菌有杀伤作用，长期使用还会破坏口腔的微生态平衡。
目前益生菌产品常用的剂型为粉剂和硬胶囊，此两种剂型虽然可以较好的保持益生菌的活性，但在应用到口腔健康产品时具有一定的弊端，硬胶囊中的产品无法接触到口腔，粉剂类产品与口腔接触时间短，益生菌难以在口腔中定殖下来发挥功效。由于益生菌对水分敏感，用水冲调后其会被快速激活，并进入生长期、衰退期，影响活菌在口腔的定殖。如果冲调水温过高，还会直接杀死益生菌，从而影响活菌功效的发挥。
仍需要有效的清新口气的制剂和方法。
发明内容
本发明的目的是提供一种有效的清新口气的制剂和方法。
本发明涉及一种用于口腔内含服的泡腾片，包含益生菌和泡腾崩解剂。
本发明还涉及益生菌和泡腾崩解剂在制备泡腾片中的用途，所述泡腾片用于通过在口腔内含服以使口气清新，缓解口臭症状，刺激口腔产生唾液，在口腔内产生微气泡，增加益生菌在口腔定殖的几率，调节口腔微生态平衡，抑制致臭菌产生臭味气体或降低口臭气体的含量。
本发明还涉及一种用于使口气清新，缓解口臭症状，刺激口腔产生唾液，在口腔内产生微气泡，增加益生菌在口腔定殖的几率，调节口腔微生态平衡，抑制致臭菌产生臭味气体或降低口臭气体的非治疗性方法，包括在口腔内含服泡腾片。
所述泡腾片通过在口腔内含服，能够使口气清新，缓解口臭症状，刺激口腔产生唾液，在口腔内产生微气泡，增加益生菌在口腔定殖的几率，调节口腔微生态平衡，抑制致臭菌产生臭味气体或降低口臭气体。
附图说明
图1是所述泡腾片对口腔异味改善的有效持续时间的图。
具体实施方式
除非另外定义，本文所用的所有技术和科学术语具有本领域技术人员通常理解的相同含义。在冲突的情况下，以包括定义在内的本文件为准。下面描述优选的方法和材料，但是与本文所述那些类似或等同的方法和材料可用于实施或测试本发明。本文公开的材料、方法和实例仅是说明性的，而非旨在限制。
对于本公开内容涉及的所有数值范围，应理解为公开了该范围内所有具体数值，以及该范围内任意两个数值限定的子范围。例如，对于1-20，应理解为公开了1、2、3、3.5、4.5、10、12、15、20等具体数值，以及1-5，2-6，3.5-7.5，15-20等子范围。
在一个方面，本发明涉及一种用于口腔内含服的泡腾片，包含益生菌和泡腾崩解剂。
在一个方面，所述益生菌是鼠李糖乳杆菌、瑞士乳杆菌、长双歧杆菌、副干酪乳杆菌、唾液链球菌、唾液乳杆菌、植物乳杆菌、嗜酸乳杆菌、罗伊氏乳杆菌、动物双歧杆菌、乳双歧杆菌、凝结芽孢杆菌或布拉迪酵母中的一种或多种。这些益生菌可以在口腔定殖，抑制腐败菌在口腔的附着；同时，益生菌可以调节免疫反应，在代谢过程中可产生过氧化氢(H2O2)，抑制变形链球菌等口腔病原菌。布拉迪酵母属于真菌类的益生菌，它可以下调促炎症反应的基因，具有抗炎的作用。益生菌通过在口腔定殖，调节口腔微生态平衡，建立健康的口腔微生态环境。
在一个方面，所述泡腾崩解剂包括有机酸和碱式碳酸盐或碱式碳酸氢盐的组合。泡腾崩解剂中的两类物质未电离不能发生反应。当放入口腔食用后，遇到口腔中的唾液，泡腾崩解剂立即发生酸碱反应，产生气泡(二氧化碳)，使片剂在口腔中慢慢崩解和融化。
在一个方面，所述有机酸是柠檬酸、酒石酸、富马酸、苹果酸或维生素C中的一种或多种；且其中所述碱式碳酸盐或碱式碳酸氢盐是碳酸氢钠、碳酸钠、碳酸氢钾、碳酸钾、碳酸钙或碳酸镁中的一种或多种。优选地，有机酸为柠檬酸、苹果酸、维生素C中的一种或多种，所述碱式碳酸盐或碱式碳酸氢盐为碳酸氢钠、碳酸钠、碳酸氢钾、碳酸钙的一种或几种组合。
在一个方面，所述的泡腾片还包含天然植物成分。
在一个方面，所述天然植物成分是甘草粉、香蕈浓缩粉、柿子浓缩粉、绿咖啡复合粉、金银花粉、绿茶粉、红茶粉中的一种或多种。中医理论认为：虚火郁热，蕴于胸胃之间，则口臭；治宜清热除湿、祛痰降火。甘草具有清热解毒，祛痰止咳的功效，甘草中的甘草酸和甘草黄酮类对多种牙周病原菌有很好的抑制和杀灭作用。甘草还具有消炎抗炎作用，可以降低口腔炎症及因炎症引起的口腔异味。香蕈中特有的蘑菇多酚和类黄酮成分可与硫醇和氨结合，加速代谢，减少异味。柿子浓缩粉含有柿子单宁，柿子单宁复杂的结构及众多的酚羟基，能与各种恶臭因子结合而达到消臭。绿咖啡复合粉和金银花都含有的绿原酸，绿原酸是一种抗菌、抗病毒、消炎的生物活性物质。金银花和甘草一样，还具有清热解毒的作用，可以改善因胃火引起的口腔异味。绿茶粉中的茶多酚是一种天然的抗菌剂，不仅对口腔的致龋菌有抑制作用，而且对牙周炎相关细菌(坏死梭杆菌、牙龈卟啉菌等)有明显的抑菌和杀菌作用。茶粉中还有多种天然活性成分，如儿茶素、茶黄素、叶绿素铜钠盐等，可以去除口腔臭味成分，也具有一定的抗菌抑菌功效。
在一个方面，所述泡腾崩解剂在所述泡腾片中的含量为20％重量至75％重量，例如20％重量至50％重量。
在一个方面，所述泡腾片在口腔内完全崩解所需的时间为5分钟或更长，例如5-15分钟。
在一个方面，所述泡腾片还包含片剂赋形剂和/或调味剂。片剂赋形剂包括山梨糖醇、乳糖、甘露糖醇、异麦芽酮糖醇、麦芽糖醇、麦芽糊精、赤藓糖醇、木糖醇、微晶纤维素等。赋形剂的作用主要是使片剂成型。调味剂包括但不限于甜味剂、酸味剂、果蔬粉、食用香精等。调味剂的作用是调节产品口感，使产品食用更加愉悦。
在一个方面，本发明涉及益生菌和泡腾崩解剂在制备本文所述的泡腾片中的用途，所述泡腾片用于通过在口腔内含服以使口气清新，缓解口臭症状，刺激口腔产生唾液，在口腔内产生微气泡，增加益生菌在口腔定殖的几率，调节口腔微生态平衡，抑制致臭菌产生臭味气体或降低口臭气体的含量。
在一个方面，本发明涉及一种用于使口气清新，缓解口臭症状，刺激口腔产生唾液，在口腔内产生微气泡，增加益生菌在口腔定殖的几率，调节口腔微生态平衡，抑制致臭菌产生臭味气体或降低口臭气体的非治疗性方法，包括在口腔内含服本文所述的泡腾片。
所述泡腾片入口后，泡腾崩解剂中的酸碱成分遇到唾液发生中和反应，并不断刺激口腔产生大量唾液以维持酸碱中和，并在口腔产生大量的微气泡。(1)消费者在服用时可以感受口腔跳跃的微气泡产生，增强愉悦的服用体验感。(2)在享受愉悦体验感同时，可以让产品在口腔中持续地进行微泡腾反应，不断地刺激口腔唾液产生，增加唾液流量，氧气供应增加。唾液流速快，流量大，口腔氧气供应充足，口腔细菌降解肽和蛋白质机会减少，从而抑制了致臭菌产生臭味气体(挥发性硫化物)。同时，唾液的冲刷作用可以不断地促进口腔的自清洁，洗去致臭菌等病原菌，从而减少异味气体的产生。(3)组合物在口腔含服并发生微泡腾作用，使组合物中的益生菌和任选的植物成分在口腔停留更长的时间，与口腔硫化物气体成分充分地作用的同时，还能增加益生菌在口腔定殖的几率。反应产生的微气泡可以增加组合物与口腔的接触面积。微气泡可以渗入到牙龈沟、牙缝、舌下等各个口腔缝隙角落，增加益生菌和组合物与口腔的接触面积和停留时间，更有利于益生菌在口腔的定殖。更多在口腔定殖的益生菌，与病原微生物具有竞争性排斥的占位效应，通过营养竞争及拮抗作用，抑制口腔中的腐败菌、致臭菌的生长，可以清除口腔中的腐败菌、致臭菌，从而达到净化口腔内环境，清新口气的作用。泡腾片的在口腔中的泡腾崩解可以更有效地促进本组合物在口腔中功效的发挥。
本发明泡腾片组合物可以即时降低三种最主要的口臭气体硫化氢，甲硫醇和二甲基硫的含量，减少口腔异味，并且口气清新效果可有效持续2h以上。长期食用所述泡腾片，可从根本上缓解口臭症状，建立健康的口腔微生态平衡及口腔内环境。
实施例
实施例一：
本组合物的泡腾崩解剂是指有机酸和碱式碳酸(氢)盐，有机酸包括柠檬酸、酒石酸、富马酸、苹果酸、维生素C(抗坏血酸)、乳酸中的一种或几种的组合，碱式碳酸(氢)盐包括碳酸氢钠、碳酸钠、碳酸氢钾、碳酸钾、碳酸钙、碳酸镁中的一种或几种的组合。作为优选，有机酸为柠檬酸、苹果酸、维生素C中的一种或几种组合，碱式碳酸(氢)盐为碳酸氢钠、碳酸钠、碳酸氢钾、碳酸钙的一种或几种组合。优选的泡腾崩解剂组合，其在口腔的泡腾愉悦感更佳，风味更协调柔和，且产品的可压性较好。表1是采用不同的有机酸和碱式碳酸(氢)盐的泡腾片的示例性配方及测试结果。
表1泡腾片的示例性配方
实施例二(泡腾片)：
将鼠李糖乳杆菌、瑞士乳杆菌、长双歧杆菌、布拉迪酵母、甘草粉、香蕈浓缩粉、绿咖啡复合粉、异麦芽酮糖醇、山梨糖醇、柠檬酸、苹果酸、碳酸氢钠、碳酸钠、三氯蔗糖、食用香精、硬脂酸镁等物料按配方量称量，根据物料性状选择是否粉碎、预混或过筛。将物料按工艺要求置于混合机中，混合至物料色泽质地均匀，用压片机进行压片。其中，泡腾崩解剂含量为35％重量，泡腾片在口腔内完全崩解所需的时间为6分钟。
实施例三(含片)：
将鼠李糖乳杆菌、瑞士乳杆菌、长双歧杆菌、布拉迪酵母、甘草粉、香蕈浓缩粉、绿咖啡复合粉、异麦芽酮糖醇、山梨糖醇、三氯蔗糖、食用香精、硬脂酸镁等物料按配方量称量，根据物料性状选择是否粉碎、预混或过筛。将物料按工艺要求置于混合机中，混合至物料色泽质地均匀，用压片机进行压片。
每单位实施例二的泡腾片与每单位实施例三的含片包含相同量的鼠李糖乳杆菌、瑞士乳杆菌、长双歧杆菌、布拉迪酵母、甘草粉、香蕈浓缩粉、绿咖啡复合粉、异麦芽酮糖醇、山梨糖醇、三氯蔗糖、食用香精和硬脂酸镁，但每单位实施例二的泡腾片额外包含柠檬酸、苹果酸、碳酸氢钠和碳酸钠作为泡腾崩解剂。
实施例四(泡腾片)：
将鼠李糖乳杆菌、副干酪乳杆菌、甘草粉、绿咖啡复合粉、绿茶粉、红茶粉、山梨糖醇、赤藓糖醇、柠檬酸、碳酸氢钠、碳酸钙、阿斯巴甜、食用香精、硬脂酸镁等物料按配方量称量，根据物料性状选择是否粉碎、预混或过筛。将物料按工艺要求置于混合机中，混合至物料色泽质地均匀，用压片机进行压片。其中，泡腾崩解剂含量为30％重量，泡腾片在口腔内完全崩解所需的时间为7分钟。
实施例五(含片)：
将唾液乳杆菌、唾液链球菌、嗜酸乳杆菌、乳双歧杆菌、甘草粉、金银花粉、香蕈浓缩粉、柿子浓缩粉、异麦芽酮糖醇、山梨糖醇、三氯蔗糖、食用香精、硬脂酸镁等物料按配方量称量，根据物料性状选择是否粉碎、预混或过筛。将物料按工艺要求置于混合机中，混合至物料色泽质地均匀，用压片机进行压片。
实施例六：
采用日本的OralChromaTM(CHM-2)便携式气相色谱仪对三种最主要的口臭气体硫化氢，甲硫醇和二甲基硫进行检测。受试者***一个一次性注射器(无针头)，注射器前端深入口腔内约4-5cm，前部悬空，不接触上颚及舌背，唇包住注射器，受试者在取样过程中用鼻呼吸。1min后缓慢抽气，将注射器内的气体快速注入仪器中，仪器依次检测出注入气体中硫化氢，甲硫醇和二甲基硫的含量。
对比测试了相同组合物配方，采用泡腾片和含片两种不同产品形式对口腔挥发性硫化物的作用效果(表2)。相比粉剂和咀嚼片等常见的益生菌产品形式，含片形式的口腔益生菌产品因在口腔停留时间更长，更有利于益生菌在口腔的定殖，对于口腔健康功效的发挥效果会更好。而对比含片，泡腾片非但没有降低口腔益生菌产品有效性，反而对口腔挥发性硫化物的降低效果更好。
表2两种不同产品形式对口腔挥发性硫化物的作用效果比较
备注：总VSC＝H2S+CH3SH+(CH3)2S
实施例七：
采用实施例六的测试方法，对本发明组合物对口腔异味改善的有效持续时间进行了研究。当口腔总挥发性硫化物(总VSC)低于150ppb时，人鼻无法嗅到口腔硫化物的臭味，即口腔无可嗅硫化物异味，口气清新。本发明泡腾片组合物可使口腔异味人群口气清新效果有效持续2h以上。见图1。
实施例八：
采用实施例六的测试方法，将本发明泡腾片组合物跟市售漱口水去除口腔异味效果进行比较，本组合物可以更好地降低口腔挥发性硫化物，其效果优于市面上杀菌抑菌的漱口水。见表3。
表3本发明与市售漱口水对口腔挥发性硫化物的作用效果比较
虽然本发明某些特征已经在本文中阐释和描述，但本领域技术人员将想到许多修改、替代、变更和等同。因此，应理解的是，所附权利要求书意在涵盖落入本发明真实精神范围之内的所有此类修改和变更。
Claims (10)
1.一种用于口腔内含服的泡腾片，包含益生菌和泡腾崩解剂。
2.根据权利要求1所述的泡腾片，其中所述益生菌是鼠李糖乳杆菌、瑞士乳杆菌、长双歧杆菌、副干酪乳杆菌、唾液链球菌、唾液乳杆菌、植物乳杆菌、嗜酸乳杆菌、罗伊氏乳杆菌、动物双歧杆菌、乳双歧杆菌、凝结芽孢杆菌或布拉迪酵母中的一种或多种。
3.根据权利要求1所述的泡腾片，其中所述泡腾崩解剂包括有机酸和碱式碳酸盐或碱式碳酸氢盐的组合。
4.根据权利要求3所述的泡腾片，其中所述有机酸是柠檬酸、酒石酸、富马酸、苹果酸或维生素C中的一种或多种；且其中所述碱式碳酸盐或碱式碳酸氢盐是碳酸氢钠、碳酸钠、碳酸氢钾、碳酸钾、碳酸钙或碳酸镁中的一种或多种。
5.根据权利要求1所述的泡腾片，还包含天然植物成分。
6.根据权利要求5所述的泡腾片，其中所述天然植物成分是甘草粉、香蕈浓缩粉、柿子浓缩粉、绿咖啡复合粉、金银花粉、绿茶粉、红茶粉中的一种或多种。
7.根据权利要求1-6中任一项所述的泡腾片，其中所述泡腾崩解剂在所述泡腾片中的含量为20％重量至75％重量，例如20％重量至50％重量。
8.根据权利要求1-6中任一项所述的泡腾片，其中所述泡腾片在口腔内完全崩解所需的时间为5分钟或更长，例如5-15分钟。
9.益生菌和泡腾崩解剂在制备根据权利要求1-8中任一项所述的泡腾片中的用途，所述泡腾片用于通过在口腔内含服以使口气清新，缓解口臭症状，刺激口腔产生唾液，在口腔内产生微气泡，增加益生菌在口腔定殖的几率，调节口腔微生态平衡，抑制致臭菌产生臭味气体或降低口臭气体的含量。
10.一种用于使口气清新，缓解口臭症状，刺激口腔产生唾液，在口腔内产生微气泡，增加益生菌在口腔定殖的几率，调节口腔微生态平衡，抑制致臭菌产生臭味气体或降低口臭气体的非治疗性方法，包括在口腔内含服根据权利要求1-8中任一项所述的泡腾片。
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| CN116492285A (zh) * | 2023-06-29 | 2023-07-28 | 深圳市波尔顿科技有限公司 | 一种用于口腔的复合益生菌组合物及其应用和产品 |
| CN116492285B (zh) * | 2023-06-29 | 2023-09-22 | 深圳市波尔顿科技有限公司 | 一种用于口腔的复合益生菌组合物及其应用和产品 |
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