CN113952405A - Anti-fatigue composition, preparation method and patch - Google Patents
Anti-fatigue composition, preparation method and patch Download PDFInfo
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- CN113952405A CN113952405A CN202111381089.7A CN202111381089A CN113952405A CN 113952405 A CN113952405 A CN 113952405A CN 202111381089 A CN202111381089 A CN 202111381089A CN 113952405 A CN113952405 A CN 113952405A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/534—Mentha (mint)
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Abstract
The invention provides an anti-fatigue composition, a preparation method and a patch, and relates to the technical field of health care products. The composition mainly comprises the following raw materials in parts by weight: 50-70 parts of turmeric, 5-8 parts of mint, 25-30 parts of lavender and 1-3 parts of mineral salt. It uses Curcuma rhizome as main functional component, has effects of warming body, dispelling cold, promoting metabolism, enhancing immunity and resisting fatigue, improves sleep quality with Lavender, refreshes mind with herba Menthae, and relieves sleepiness; the mineral salt is used for improving the absorption and utilization rate of other raw materials, maintaining the normal metabolism of skin cutin and synergistically achieving the anti-fatigue effect. In addition, the turmeric, the mint and the lavender have aromatic flavors, so that the use interest of a user can be improved. The preparation method of the composition can dissolve out effective components in the raw materials, and improve absorption utilization rate. The patch prepared from the composition can enhance absorption effect of body on effective components under the action of heat generated by the self-heating layer.
Description
Technical Field
The invention relates to the technical field of health care products, in particular to an anti-fatigue composition, a preparation method and a patch.
Background
Fatigue refers to the weakness of body functions caused by hyperkinesia, lack of sleep, diseases and other reasons, and the subjective discomfort of tiredness, hypodynamia, muscle soreness, insomnia, palpitation and the like, and causes low immunity, easy cold susceptibility, aging acceleration, and decline of working and learning abilities.
Modern medical research shows that the accumulation of energy substances, accumulation of 'fatigue toxin' fuscid, ammonia, urea, carbon dioxide and the like, free radical accumulation, immune function reduction or disorder and the like play an important role in the fatigue generation process. With the acceleration of the pace of life of modern society, especially some white-collar men and women in offices face increasingly more fatigued states, the pressure of life is large, the people lack exercise, and the physical aspect can be represented by fatigue, weakness, muscle and joint ache, dizziness, headache, palpitation, chest distress, sleep disorder, inappetence, abdominal discomfort, loose stool, constipation, sexual hypofunction, cold and heat intolerance, easy cold, dry eyes and the like; psychological aspects can be manifested by depressed mood, dysphoria, irritability, fear, timidity, memory decline, inability to concentrate, energy deficiency, slow response, etc.; in the aspect of social interaction, the people can not well bear corresponding social roles, work and study are difficult, interpersonal relationship and family relationship can not be processed normally, normal social interaction is difficult to carry out, and the body is in a fatigue state for a long time.
Therefore, it is important to develop an anti-fatigue composition.
Disclosure of Invention
The invention aims to provide an anti-fatigue composition which can promote metabolism capability and has the effects of relieving nervous tension, soothing nerves, helping sleep and relieving sleepiness.
Another object of the present invention is to provide a method for preparing an anti-fatigue composition, which can dissolve out active ingredients in raw materials and accelerate the absorption and utilization rate of the body.
Another object of the present invention is to provide an anti-fatigue patch, which can make the composition prepared as described above into a self-heating patch with better applicability and convenience.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the invention provides an anti-fatigue composition, which mainly comprises the following raw materials in parts by weight: 50-70 parts of turmeric, 5-8 parts of mint, 25-30 parts of lavender and 1-3 parts of mineral salt.
On the other hand, the invention provides a preparation method of an anti-fatigue composition, which mainly comprises the following steps:
mixing the raw materials except mineral salts with water, distilling, and separating to obtain distillate oil and distillate liquid; concentrating the distillate, mixing with filler, and drying to obtain soft extract; mixing the soft extract, distillate oil and mineral salt, and drying to obtain the composition.
In another aspect, the invention provides an anti-fatigue patch, which comprises a self-heating layer, an efficacy layer and an anti-adhesion layer, wherein the self-heating layer, the efficacy layer and the anti-adhesion layer are sequentially covered, the efficacy layer is composed of the composition prepared by the method, and the self-heating layer is composed of iron powder, activated carbon and water.
The anti-fatigue composition and the preparation method thereof provided by the embodiment of the invention have at least the following beneficial effects:
on one hand, the invention provides an anti-fatigue composition, which mainly comprises the following raw materials in parts by weight: 50-70 parts of turmeric, 5-8 parts of mint, 25-30 parts of lavender and 1-3 parts of mineral salt. The composition has effects of warming body, dispelling cold, promoting metabolism, enhancing immunity and resisting fatigue by using Curcuma rhizome as main functional component, improving sleep quality by using Lavender as raw material for tranquilizing mind and improving sleep, and relieving sleepiness by using herba Menthae as raw material for refreshing brain; the mineral salt is used for improving the absorption and utilization rate of other raw materials, maintaining the normal metabolism of skin cutin and synergistically achieving the anti-fatigue effect. In addition, the turmeric, the mint and the lavender have aromatic flavors, so that the use interest of a user can be improved.
On the other hand, the invention also provides a preparation method of the anti-fatigue composition, which can dissolve out the effective components from the raw materials and improve the absorption and utilization rate of the effective components.
On the other hand, the invention also provides an anti-fatigue patch, which takes the composition prepared by the preparation method as an efficacy layer, and a self-heating layer consisting of iron powder, activated carbon and water generates heat, when the two layers are combined for use, the self-generated heat can activate the effective ingredients in the composition, and the absorption and utilization rate of the effective ingredients by the body is enhanced.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The invention provides an anti-fatigue composition, which mainly comprises the following raw materials in parts by weight: 50-70 parts of turmeric, 5-8 parts of mint, 25-30 parts of lavender and 1-3 parts of mineral salt. The specific effects of the raw materials are as follows:
yellow ginger: curcuma rhizome is a plant of Dioscorea of Dioscoreaceae, also called Dioscorea zingiberensis and Dioscorea zingiberensis Wright. The turmeric is pungent and bitter in taste and warm in nature, enters spleen and liver channels, has the effects of breaking blood and promoting qi circulation and clearing channels and relieving pain, and is mainly used for treating diseases such as stabbing pain in chest and hypochondrium, chest stuffiness and pain, dysmenorrheal amenorrhea, abdominal mass, rheumatism, shoulder and arm pain, traumatic injury and swelling pain and the like.
The yellow ginger is rich in pungent and pungent components such as gingerol and the like, and can stimulate local blood microcirculation to ensure smooth blood circulation, further enhance the activity of intestines and stomach, heart and kidney, promote the metabolism of organisms and further achieve the effect of dispelling cold and raising temperature. In addition, the pungent component in Curcuma rhizome can stimulate organism to generate exciting signal, promote metabolism, and resist aging.
It should be noted that in the present invention, the yellow ginger is selected from Yunnan plateau small yellow ginger.
Mint: it has pungent and cool nature, and has effects of dispersing wind-heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing, and can be used for treating wind-heat common cold, headache, sore throat, food stagnation, flatulence, aphtha, toothache, scabies, urticaria, early stage of epidemic febrile disease, rubella pruritus, stagnation of qi due to depression of liver, chest distress, hypochondriac pain, etc.
It should be noted that mint is rich in mint flavone, which has a strong ability to scavenge free radicals, and therefore, can scavenge free radicals, thereby preventing the accumulation of free radicals in the body, such as oxygen free radicals associated with fatigue, and achieving an anti-fatigue effect.
In addition, the peppermint oil in the peppermint can quickly permeate into tissues and local blood microcirculation from the surface layer of the skin, so the peppermint oil composition has a high permeation speed, can quickly exert the effect and has a good anti-fatigue effect.
Lavender: the tea is also called as perfume plant, lysimachia foenum-graecum hance, vanilla and lysimachia foenum-graecum hance, and the main components of the tea are linalool, linalyl acetate, eucalyptol, B-roxilene pair, lavender acetate, lavender alcohol, terpene-4-alcohol, camphor and the like, so that the sleeping condition of a user can be effectively improved, and the effects of calming nerves and helping sleep are better.
It should be noted here that lavender has a better antibacterial effect due to the action of linalool, so that the shelf life of the composition is longer.
Mineral salt: the mineral salt is a salt containing many minerals, and has the advantages of health promotion and easy absorption. The mineral salt can further assist the yellow ginger, enhance the metabolism of organisms, and can improve the antibacterial and bactericidal capability together with the lavender, so that the using effect is good.
In conclusion, the composition takes the yellow ginger as a main functional component, has the effects of warming the body, dispelling cold, promoting metabolism, improving immunity and resisting fatigue, takes the lavender as a raw material for soothing the nerves and helping sleep, improves the sleep quality, takes the mint as a raw material for refreshing and restoring consciousness, and relieves sleepiness; the mineral salt is used for improving the absorption and utilization rate of other raw materials, maintaining the normal metabolism of skin cutin and synergistically achieving the anti-fatigue effect. In addition, the turmeric, the mint and the lavender have aromatic flavors, so that the use interest of a user can be improved.
It should be noted that the patients with damp-cold constitution have the manifestations of visceratosis, impaired digestion and absorption of nutrients, and the symptoms of mental weakness, fatigue, pale face, pale lips, aversion to cold, fear of blowing, cold hands and feet, and diarrhea. According to the invention, due to the matching of the raw materials, the composition has a good conditioning effect on cold-dampness constitution, can effectively improve the problems and has a good using effect.
In the invention, the composition also comprises the following raw materials in parts by weight: 5-8 parts of oriental wormwood, 3-6 parts of fructus kochiae and 5-8 parts of radix sophorae flavescentis, wherein the effects of the raw materials are as follows:
herba artemisiae scopariae: bitter and pungent in taste, slightly cold in nature, entering spleen, stomach, liver and gallbladder channels, has effects of clearing damp-heat, promoting bile flow and eliminating jaundice, and can be used for treating jaundice, oliguria, damp-warm and summer-damp, and eczema and pruritus.
The preparation method comprises the following steps of (1) preparing broom cypress fruit: pungent and bitter taste, cold nature, entering kidney and bladder channels, has effects of clearing heat, promoting diuresis, dispelling pathogenic wind and relieving itching, and can be used for treating symptoms such as urination pain, pudendal pruritus, leukorrhagia, rubella, eczema and skin pruritus.
Flavescent sophora root: bitter taste and cold nature, enters heart, liver, stomach, large intestine and bladder channels, has the effects of clearing heat and drying dampness, killing parasites and promoting urination, and is mainly used for treating symptoms such as dysentery with heat, hematochezia, jaundice anuresis, leucorrhea with reddish discharge, vulva swelling and pruritus vulvae, eczema, skin pruritus, mange and leprosy.
In conclusion, when the oriental wormwood, the fructus kochiae and the radix sophorae flavescentis are used as raw materials, the heat clearing and toxin expelling effects of the composition can be enhanced, and meanwhile, the composition can be suitable for skin with rash and spots and is high in applicability.
In the invention, the composition also comprises 1 to 3 weight parts of white mulberry root-bark and 1 to 3 weight parts of rhizoma alismatis.
The mulberry bark is sweet in taste and cold in nature, enters lung and spleen channels, has the effects of purging lung heat, relieving asthma, promoting diuresis and relieving swelling and is mainly used for treating lung heat, cough and asthma, oliguria and edema, swelling of face and skin and other symptoms.
Rhizoma alismatis: sweet and light taste, cold nature, entering kidney and bladder channels, has the effects of promoting diuresis, excreting dampness, clearing heat, eliminating turbid pathogen and reducing blood lipid, and is mainly used for treating dysuresia, edema and fullness, diarrhea and oliguria, phlegm-fluid vertigo, heat stranguria and pain astringency, hyperlipidemia and other diseases.
In conclusion, when the cortex mori radicis and the rhizoma alismatis are used as raw materials of the composition, the limb edema can be eliminated, and the using effect of the composition can be enhanced.
The invention also provides a preparation method of the anti-fatigue composition, which mainly comprises the following steps:
mixing the raw materials except mineral salts with water, distilling, and separating to obtain distillate oil and distillate liquid; concentrating the distillate, mixing with filler, and drying to obtain soft extract; mixing the soft extract, distillate oil and mineral salt, and drying to obtain the composition.
Specifically, raw materials except mineral salts are mixed with water, and distillation is carried out at 38-42 ℃, namely when the water just starts to generate steam, the water can quickly penetrate plant cell walls and cell membranes, active ingredients contained in the water are dissolved in the steam and distilled off, and the distillate is collected after condensation to obtain the distillate.
Distilling at the temperature for 1.5-2.5 h to completely extract the effective components. When the distillation temperature is higher, the temperature of steam is also higher, which is easy to destroy the effective components in the raw materials and influence the use effect of the composition. When the temperature is lower, the steam generation amount is insufficient, the extraction effect is poor, the utilization rate of raw materials is lower, and the cost performance is lower.
In addition, when the temperature is lower, the steam is less, and the generated steam is easier to bypass the raw materials and passes through the gaps of the raw materials, so that the extraction effect cannot be achieved.
According to the invention, the mass ratio of the raw materials except mineral salts to water is (2-3):1, when the mixture is placed in a distillation container, the water is positioned below the raw materials, at the moment, the water is heated to generate steam, and the steam can move from bottom to top and completely passes through the raw materials, so that a better distillation effect is achieved.
When the content of water is large, the raw material is more partially soaked in water, and the distillate effect of the raw material soaked in water is not good at low temperature. The partial raw materials need to be distilled off at high temperature, but the structure of the effective components is easy to be damaged at high temperature, so that the effective components lose activity, and the using effect is poor.
It should be noted that the raw materials may also be placed above the mixed water, for example, by steaming, to achieve the distillation effect.
After distillation, the distillate and the distillate can be separated by means of liquid separation. And standing can be carried out before liquid separation, and the standing time is 30-60 min, so that the distillate oil and the distillate oil are layered, the liquid separation is convenient, and the liquid separation difficulty is reduced.
Then, after the distillate is concentrated by 5-8 times, the concentrated solution is prepared, the volume of the distillate can be effectively reduced, the subsequent drying cost can be reduced, meanwhile, the concentrated solution is convenient to transport and store, and the practicability is higher.
And then the mass ratio of the concentrated solution to the filler is 1 (0.5-0.8), so that the concentrated solution can be converted from a liquid state to a thick paste state, the powder is convenient to prepare, and the portability and the practicability of the composition are enhanced. When the content of the filler is higher, the texture of the thick paste is drier, and at the moment, the cost required in the process of mixing the thick paste with other raw materials is higher, the operation difficulty is higher, and the mixing uniformity is lower. When the content of the filler is low, the filler cannot play the effects of filling, increasing the solid volume and reducing the content of the effective components, so that the single composition is easy to cause high effective components, strong stimulation to organisms and poor use feeling.
In the present invention, the filler may be selected from a vegetable gel and/or an animal gel. The plant gel has skin regeneration promoting, antiinflammatory and tranquilizing effects. The animal gel can activate cells, enhance skin elasticity, and has good moisturizing effect. Therefore, the plant gel and the animal gel have better effects, are easy to absorb water and are beneficial to skin absorption.
In the invention, in order to ensure that the composition has better absorption and utilization rate when being externally applied, the moisture content of the composition is between 10 and 15 percent after being dried, and the moisture in the composition can be used as a medium to enhance the absorption and utilization rate of the skin.
The invention provides an anti-fatigue patch which mainly comprises a self-heating layer, an effect layer and an anti-sticking layer which are sequentially covered, wherein the effect layer is composed of the composition prepared by the method, and the self-heating layer is composed of iron powder, activated carbon and water.
Specifically, the self-heating layer is composed of iron powder, activated carbon and water. When the composition is contacted with the skin, the composition can generate heat automatically, the efficacy layer covering the self-heating layer can further stimulate the activity of effective components in the composition under the condition of heat, and the composition is continuously guided into pores through steam generated by the self-heating layer to achieve the expected effect.
In the invention, the patch can be pasted on the sole of a foot to enhance the stimulation effect of the patch on the acupuncture points of the sole of the foot, thereby achieving the effects of better dredging collaterals, activating collaterals and promoting blood circulation.
In the invention, the self-heating layer is composed of high-purity iron powder, activated carbon and water, and can generate steam in the heating process, thereby improving the use effect.
It should be noted that the water content of the composition is 10% -15%, so when the self-heating layer generates heat, steam is generated to activate the effective components in the composition, and simultaneously, the water in the composition is converted into steam to enhance the effect and achieve the expected use effect.
It should also be noted that the patch can be applied to the foot in a form of covering the foot, that is, the patch is applied to the foot without gluing, so that the pain caused by tearing can be reduced, and the patch is more suitable for the population. Specifically, the part of the efficacy layer covering the self-heating layer can be externally applied to the foot by adopting a direct sleeving manner, so that the using effect is achieved.
In addition, the patch can be made into daily use type and night use type according to more practical conditions, such as content of the efficacy layer, heating time of the self-heating layer and the like, so as to achieve better use condition.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The present embodiment aims to provide an anti-fatigue composition, which comprises the following raw materials:
60kg of turmeric, 6.5kg of mint, 28kg of lavender and 2kg of mineral salt.
The preparation method of the composition comprises the following steps:
mixing the raw materials except mineral salts with water at a mass ratio of 2.5:1, distilling at 40 deg.C for 2 hr, standing for 45min, and separating to obtain distillate and distillate;
concentrating the distillate by 7 times, mixing with plant gel, and drying to obtain soft extract; and mixing the thick paste, the distillate oil and the mineral salt, and drying to obtain the composition, wherein the water content of the composition is 12-13%.
Example 2
The present embodiment aims to provide an anti-fatigue composition, which comprises the following raw materials:
50kg of turmeric, 5kg of mint, 25kg of lavender, 1kg of mineral salt, 5kg of oriental wormwood, 3kg of fructus kochiae and 5kg of radix sophorae flavescentis.
The preparation method of the composition comprises the following steps:
mixing the raw materials except mineral salts with water at a mass ratio of 2:1, distilling at 38 deg.C for 1.5 hr, standing for 30min, and separating to obtain distillate and distillate;
concentrating the distillate by 5 times, mixing with plant gel, and drying to obtain soft extract; and mixing the thick paste, the distillate oil and the mineral salt, and drying to obtain the composition, wherein the water content of the composition is 10-11%.
Example 3
The present embodiment aims to provide an anti-fatigue composition, which comprises the following raw materials:
70kg of turmeric, 8kg of mint, 30kg of lavender, 3kg of mineral salt, 8kg of oriental wormwood, 6kg of fructus kochiae, 8kg of radix sophorae flavescentis, 3kg of cortex mori and 3kg of rhizoma alismatis.
The preparation method of the composition comprises the following steps:
mixing the raw materials except mineral salts with water at a mass ratio of 3:1, distilling at 42 deg.C for 2.5 hr, standing for 60min, and separating to obtain distillate and distillate;
concentrating the distillate by 8 times, mixing with plant gel, and drying to obtain soft extract; and mixing the thick paste, the distillate oil and the mineral salt, and drying to obtain the composition, wherein the water content of the composition is 14-15%.
Example 4
The present embodiment aims to provide an anti-fatigue composition, which comprises the following raw materials:
55kg of turmeric, 6kg of mint, 26kg of lavender, 1.5kg of mineral salt, 6kg of oriental wormwood, 4kg of fructus kochiae, 6kg of radix sophorae flavescentis, 1kg of cortex mori and 1kg of rhizoma alismatis.
The preparation method of the composition comprises the following steps:
mixing the raw materials except mineral salts with water at a mass ratio of 2.3:1, distilling at 39 deg.C for 1.8 hr, standing distillate for 40min, and separating to obtain distillate and distillate;
concentrating the distillate by 6 times, mixing with plant gel, and drying to obtain soft extract; and mixing the thick paste, the distillate oil and the mineral salt, and drying to obtain the composition, wherein the water content of the composition is 12-13%.
The prepared composition is used as an effect layer, a self-heating layer consisting of iron powder, activated carbon and water is combined with the effect layer, and an anti-sticking layer is combined on one side of the effect layer, which is far away from the self-heating layer.
Example 5
The present embodiment aims to provide an anti-fatigue composition, which comprises the following raw materials:
65kg of turmeric, 7kg of mint, 28kg of lavender, 2.5kg of mineral salt, 7kg of oriental wormwood, 5kg of fructus kochiae, 7kg of radix sophorae flavescentis, 2kg of cortex mori and 2kg of rhizoma alismatis.
The preparation method of the composition comprises the following steps:
mixing the raw materials except mineral salts with water at a mass ratio of 2.8:1, distilling at 41 deg.C for 2.3 hr, standing distillate for 55min, and separating to obtain distillate and distillate;
concentrating the distillate by 6 times, mixing with plant gel, and drying to obtain soft extract; and mixing the thick paste, the distillate oil and the mineral salt, and drying to obtain the composition, wherein the water content of the composition is 13-14%.
The prepared composition is used as an effect layer, a self-heating layer consisting of iron powder, activated carbon and water is combined with the effect layer, and an anti-sticking layer is combined on one side of the effect layer, which is far away from the self-heating layer.
Example 6
The present embodiment aims to provide an anti-fatigue composition, which comprises the following raw materials:
60kg of turmeric, 6.5kg of mint, 28kg of lavender and 2kg of mineral salt.
The preparation method of the composition comprises the following steps:
mixing the raw materials except mineral salts with water at a mass ratio of 2.8:1, distilling at 41 deg.C for 2.3 hr, standing distillate for 55min, and separating to obtain distillate and distillate;
concentrating the distillate by 6 times, mixing with plant gel, and drying to obtain soft extract; and mixing the thick paste, the distillate oil and the mineral salt, and drying to obtain the composition, wherein the water content of the composition is 13-14%.
The prepared composition is used as an effect layer, a self-heating layer consisting of iron powder, activated carbon and water is combined with the effect layer, and an anti-sticking layer is combined on one side of the effect layer, which is far away from the self-heating layer.
Effect example 1
In examples 1 to 6, the yellow ginger is yunnan plateau yellow ginger, and the yellow ginger is rich in beta-carotene, calcium, magnesium, manganese, phosphorus, sodium and potassium through component analysis, so that the plateau yellow ginger is rich in nutrient elements. Meanwhile, the gingerol is detected to be curcumin, and the test result is shown in the following table:
TABLE 1 test results
Therefore, the Yunnan plateau yellow ginger is used as one of the raw materials of the composition, and the gingerol content in the composition is higher (compared with that in the conventional yellow ginger), so that the composition has better effects of dispelling cold, dredging collaterals, warming the body and resisting fatigue and higher use value.
Effect example 2
The neck labels prepared in examples 4 to 6 were randomly sampled as samples and tested for their temperature after heat generation, and the test results are shown in Table 2.
TABLE 2 test results
As can be seen from Table 2, the neck patches prepared in examples 4-6 have a maximum temperature of 40 deg.C, do not cause scald damage to the skin, and also enable the composition to have good effect and high use value.
Effect example 3
Adult male mice 70 with a body weight of 16g to 19g and an average body weight of 17.1g were selected and randomly grouped into blank groups and example 1 to example 6 groups. The body hair was removed from the back of the mouse and the exposed area of the skin was 3cm by 3cm, and the products prepared in examples 1 to 6 were applied to the back of the mouse. Here, the compositions prepared in examples 1 to 3 were the same as the patches prepared in examples 4 to 6 in the content of the effective ingredient, and the same means that the content error is less than 2%. After being taken once a day for 1 week continuously, the mice were subjected to a swimming test with a weight, and the test results are shown in table 3.
Also, the mice were subjected to a weight swimming time test before using the products prepared in examples 1 to 6, and the test conditions were identical to those after the application of the drug.
In the experiment, the blank group of mice was fed in the same feeding manner and cultured in the same environment as the groups of examples 1-6.
TABLE 3 results of the experiment
As can be seen from the above table, after the product is used, the weight-bearing swimming time of the mice is longer than that before the product is applied, and after the product is applied, the weight-bearing swimming time of the mice is longer than that of the mice in the blank group, so that the anti-fatigue effect of the product is better. Meanwhile, the patch products of the groups of examples 4 to 6 have better self-heating effect and can effectively promote the absorption of effective components in the composition, so the anti-fatigue effect is better.
In summary, the invention provides an anti-fatigue composition, which mainly comprises the following raw materials in parts by weight: 50-70 parts of turmeric, 5-8 parts of mint, 25-30 parts of lavender and 1-3 parts of mineral salt. The composition has effects of warming body, dispelling cold, promoting metabolism, enhancing immunity and resisting fatigue by using Curcuma rhizome as main functional component, improving sleep quality by using Lavender as raw material for tranquilizing mind and improving sleep, and relieving sleepiness by using herba Menthae as raw material for refreshing brain; the mineral salt is used for improving the absorption and utilization rate of other raw materials, maintaining the normal metabolism of skin cutin and synergistically achieving the anti-fatigue effect. In addition, the turmeric, the mint and the lavender have aromatic flavors, so that the use interest of a user can be improved.
On the other hand, the invention also provides a preparation method of the anti-fatigue composition, which can dissolve out the effective components from the raw materials and improve the absorption and utilization rate of the effective components.
On the other hand, the invention also provides an anti-fatigue patch, which takes the composition prepared by the preparation method as an efficacy layer, and a self-heating layer consisting of iron powder, activated carbon and water generates heat, when the two layers are combined for use, the self-generated heat can activate the effective ingredients in the composition, and the absorption and utilization rate of the effective ingredients by the body is enhanced.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The anti-fatigue composition is characterized by comprising the following raw materials in parts by weight: 50-70 parts of turmeric, 5-8 parts of mint, 25-30 parts of lavender and 1-3 parts of mineral salt.
2. The anti-fatigue composition according to claim 1, comprising the following raw materials in parts by weight: 5-8 parts of oriental wormwood, 3-6 parts of fructus kochiae and 5-8 parts of radix sophorae flavescentis.
3. The anti-fatigue composition as claimed in claim 1, comprising 1-3 parts by weight of cortex mori radicis and 1-3 parts by weight of rhizoma alismatis.
4. A process for the preparation of an anti-fatigue composition according to any of claims 1 to 3, comprising the steps of:
mixing the raw materials except mineral salts with water, distilling, and separating to obtain distillate oil and distillate liquid; concentrating the distillate, mixing with filler, and drying to obtain soft extract; mixing the soft extract, distillate oil and mineral salt, and drying to obtain the composition.
5. The production method according to claim 4, wherein the mass ratio of the raw materials other than the mineral salt to water is (2-3): 1.
6. The method according to claim 4, wherein the temperature of the distillation is 38 ℃ to 42 ℃ and the time of the distillation is 1.5h to 2.5 h.
7. The production method according to claim 4, wherein the mass ratio of the filler to the concentrated distillate is (0.5-0.8): 1.
8. The method according to claim 7, wherein the filler is a vegetable gel and/or an animal gel.
9. The method of any one of claims 5 to 8, wherein the composition has a water content of 10% to 15%.
10. An anti-fatigue patch, comprising a self-heating layer, an efficacy layer and an anti-adhesion layer, which are sequentially laminated, wherein the efficacy layer is composed of the composition prepared according to any one of claims 4 to 9, and the self-heating layer is composed of iron powder, activated carbon and water.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496887A (en) * | 2008-12-24 | 2009-08-05 | 闫吉强 | Medicament for treating acute hot, itching and wet severe type and chronic urticaria |
| CN104974720A (en) * | 2014-04-11 | 2015-10-14 | 上海暖友实业有限公司 | Thin-sheet-type self-heating element, preparation method and application thereof |
| CN112451201A (en) * | 2020-11-26 | 2021-03-09 | 郑程程 | Self-heating patch for pediatrics and preparation method thereof |
-
2021
- 2021-11-20 CN CN202111381089.7A patent/CN113952405A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496887A (en) * | 2008-12-24 | 2009-08-05 | 闫吉强 | Medicament for treating acute hot, itching and wet severe type and chronic urticaria |
| CN104974720A (en) * | 2014-04-11 | 2015-10-14 | 上海暖友实业有限公司 | Thin-sheet-type self-heating element, preparation method and application thereof |
| CN112451201A (en) * | 2020-11-26 | 2021-03-09 | 郑程程 | Self-heating patch for pediatrics and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| （英）苏珊.柯蒂斯等著: "《芳香精油宝典》", 30 November 2018, 中国轻工业出版社 * |
| 可可: "#头道小黄将#高原黄姜足贴/懒人必备除湿器", 《HTTPS://WWW.XIAOHONGSHU.COM/DISCOVERY/ITEM/6103485A000000002103463E》 * |
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