CN113929648A - Preparation method of cyclobutane-1, 2-dicarboxylic anhydride and intermediate thereof - Google Patents
Preparation method of cyclobutane-1, 2-dicarboxylic anhydride and intermediate thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- NMNZZIMBGSGRPN-UHFFFAOYSA-N 3-oxabicyclo[3.2.0]heptane-2,4-dione Chemical compound O=C1OC(=O)C2CCC12 NMNZZIMBGSGRPN-UHFFFAOYSA-N 0.000 title abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 66
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000003513 alkali Substances 0.000 claims abstract description 9
- 239000002253 acid Substances 0.000 claims abstract description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 8
- 238000006243 chemical reaction Methods 0.000 claims description 39
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 15
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 15
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 8
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 claims description 4
- 239000012346 acetyl chloride Substances 0.000 claims description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 4
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 claims description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 3
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 claims description 3
- 229910000024 caesium carbonate Inorganic materials 0.000 claims description 3
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 claims description 3
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 claims description 3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 239000007810 chemical reaction solvent Substances 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 230000003301 hydrolyzing effect Effects 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims description 2
- 239000012312 sodium hydride Substances 0.000 claims description 2
- 229910000104 sodium hydride Inorganic materials 0.000 claims description 2
- DQHIGEQXJBMKKY-UHFFFAOYSA-N methyl 2,4-dibromobutanoate Chemical compound COC(=O)C(Br)CCBr DQHIGEQXJBMKKY-UHFFFAOYSA-N 0.000 abstract description 6
- 238000009776 industrial production Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 4
- SUSAGCZZQKACKE-UHFFFAOYSA-N cyclobutane-1,2-dicarboxylic acid Chemical compound OC(=O)C1CCC1C(O)=O SUSAGCZZQKACKE-UHFFFAOYSA-N 0.000 abstract description 3
- MLIREBYILWEBDM-UHFFFAOYSA-M 2-cyanoacetate Chemical compound [O-]C(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-M 0.000 abstract description 2
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 16
- 238000003756 stirring Methods 0.000 description 14
- 238000001914 filtration Methods 0.000 description 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 9
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 9
- 238000001816 cooling Methods 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 239000000706 filtrate Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000012043 crude product Substances 0.000 description 6
- 239000000543 intermediate Substances 0.000 description 6
- 238000004321 preservation Methods 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 238000005160 1H NMR spectroscopy Methods 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 239000012065 filter cake Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 3
- 238000004537 pulping Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- -1 AMG-176 compound Chemical class 0.000 description 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 description 2
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- ZIUSEGSNTOUIPT-UHFFFAOYSA-N ethyl 2-cyanoacetate Chemical compound CCOC(=O)CC#N ZIUSEGSNTOUIPT-UHFFFAOYSA-N 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- JQNINBDKGLWYMU-GEAQBIRJSA-N CO[C@H]1\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(OC[C@]4(CCCC5=C4C=CC(Cl)=C5)CN3C[C@@H]3CC[C@@H]13)C=C2 Chemical compound CO[C@H]1\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(OC[C@]4(CCCC5=C4C=CC(Cl)=C5)CN3C[C@@H]3CC[C@@H]13)C=C2 JQNINBDKGLWYMU-GEAQBIRJSA-N 0.000 description 1
- 206010066476 Haematological malignancy Diseases 0.000 description 1
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 description 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- ANGDWNBGPBMQHW-UHFFFAOYSA-N methyl cyanoacetate Chemical compound COC(=O)CC#N ANGDWNBGPBMQHW-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Abstract
The invention relates to a preparation method of cyclobutane-1, 2-dicarboxylic anhydride (a compound shown in a formula I) and an intermediate thereof, in particular to a preparation method of a compound shown in a formula IV, which comprises the following steps of taking methyl 2, 4-dibromobutyrate (a compound shown in a formula II) as a raw material, and carrying out ring closure on the methyl 2, 4-dibromobutyrate and cyanoacetate (a compound shown in a formula III) under an alkaline condition to generate a compound shown in a formula IV; the compound of formula IV is hydrolyzed and decarboxylated under the action of acid or alkali to generate cyclobutane-1, 2-dicarboxylic acid (the compound of formula V); the compound of formula V is cyclized under the action of a dehydrating reagent to form cyclobutane-1, 2-dicarboxylic anhydride (compound of formula I). The method has the advantages of simple and safe operation, good yield, good economic effect and suitability for industrial production.
Description
Technical Field
The invention relates to the field of synthesis of drug intermediates, in particular to cyclobutane-1, 2-dicarboxylic anhydride and a preparation method and application of an intermediate thereof.
Background
The research of the medicine for treating the hematological malignancy is an important research subject at home and abroad, and the AMG-176 compound developed by Amgen is a selective MCL-1 inhibitor and shows curative effect in various hematological malignancies. Cyclobutane-1, 2-dicarboxylic anhydride is an important intermediate for the synthesis of AMG-176.
The literature Tetrahedron: Asymmetry,14(1), 127-; 2003 discloses the synthesis of the intermediate cyclobutane-1, 2-dicarboxylic acid of the compound of formula I:
in the synthetic route, the second step of reaction needs to use a highly toxic potassium cyanide, so that the production process has certain danger and is not suitable for industrial production.
Therefore, the development of a preparation method of cyclobutane-1, 2-dicarboxylic anhydride suitable for industrial production is of great significance.
Disclosure of Invention
The invention aims to overcome the defect that the prior art needs to use sodium cyanide or potassium cyanide and other highly toxic products for synthesizing the cyclobutane-1, 2-dicarboxylic anhydride and is not suitable for industrial production. Provides a preparation method of cyclobutane-1, 2-dicarboxylic anhydride, which has the advantages of safe industrialization, high yield, low cost and easy operation.
The invention provides a preparation method of a compound shown in a formula I, which comprises the following steps:
the method comprises the following steps: a compound of a formula II and a compound of a formula III are subjected to ring closing under the action of alkali 1 to prepare a compound of a formula IV;
step two: hydrolyzing the compound shown in the formula IV under the action of acid or alkali 2 to remove carboxyl to generate a compound shown in the formula V;
step three: the compound of the formula V is subjected to ring closing under the action of a dehydrating reagent to generate a compound of a formula I;
wherein R is methyl or ethyl.
Preferably, in the first step, the base 1 is one or more selected from potassium carbonate, cesium carbonate, potassium tert-butoxide or sodium hydride; the reaction solvent is selected from one or more of acetonitrile, dioxane, glycol dimethyl ether or toluene.
Preferably, in the first step, the molar ratio of the compound of formula II to the compound of formula III is 1: 1-1.2; the reaction temperature range is 70-90 ℃.
Preferably, in the second step, the acid is hydrochloric acid or sulfuric acid; the alkali 2 is sodium hydroxide or potassium hydroxide.
Preferably, in the second step, the molar ratio of the compound shown in the formula IV to the acid or base 2 is 1: 4-5; the reaction temperature range is 90-110 ℃.
Preferably, in the third step, the dehydrating reagent is one or more selected from acetyl chloride, acetic anhydride, phosphorus pentoxide or trifluoroacetic anhydride.
Preferably, in the third step, the molar ratio of the compound shown in the formula V to the dehydrating reagent is 1: 2-5; the reaction temperature range is 60-100 ℃.
Advantageous effects
The invention provides a preparation method of cyclobutane-1, 2-dicarboxylic anhydride (a compound shown in a formula I) and an intermediate thereof, which comprises the following steps of taking 2, 4-dibromobutyric acid methyl ester (a compound shown in a formula II) as a raw material, and carrying out a ring-closing reaction with cyanoacetate (a compound shown in a formula III) under an alkaline condition to generate a compound shown in a formula IV; the compound of formula IV is hydrolyzed and decarboxylated under the action of acid or alkali to generate cyclobutane-1, 2-dicarboxylic acid (the compound of formula V); the compound of formula V is cyclized under the action of a dehydrating reagent to form cyclobutane-1, 2-dicarboxylic anhydride (compound of formula I). The method has the advantages of no need of using highly toxic sodium cyanide or potassium cyanide, cheap and easily available raw materials, simple and safe operation, good yield, good economic effect and suitability for industrial production.
The AMG-176 compound developed by Amgen company can be synthesized by the following process route:
Detailed Description
The present invention will be further illustrated by the following specific examples, which are carried out on the premise of the technical scheme of the present invention, and it should be understood that these examples are only for illustrating the present invention and are not intended to limit the scope of the present invention.
Example 1
Preparation of the compound of formula IV:
ethyl cyanoacetate (8.80kg,77.5mol,1.0eq.), acetonitrile (80.0kg) and methyl 2, 4-dibromobutyrate (20.0kg,77.5mol,1.0eq.) were added to the reaction kettle, and the stirring was started. Powdered potassium carbonate (26.8kg,193.7mol,2.5eq.) was added in portions with stirring, and the mixture was heated to 70-75 ℃ for reaction for 12 hours. Filtering, concentrating the filtrate under reduced pressure to remove the solvent, adding 37.0kg of MTBE into the residue, washing with 10.0kg of 10% saline solution, drying and concentrating to obtain a crude product of the compound IV-1, carrying out reduced pressure distillation on the crude product by a high vacuum pump (180-230 pa), and collecting a fraction at 95-105 ℃ to obtain 11.70kg of a light yellow liquid of the compound IV-1 with the yield of 71.4%.1HNMR(400MHz，CDCl3)：δ(ppm)4.28～4.35(m，2H)；3.71～3.84(m，4H)；2.53～2.71(m，3H)；2.27～2.30(m，1H)；1.35～1.38(m，3H)。
Preparation of a Compound of formula V:
adding the compound (22.48kg, 106.5mol, 1.0eq.) of the formula IV-1 and 18.7kg of process water into a reaction kettle, adding 36% hydrochloric acid (41.8kg) into the reaction kettle, starting stirring, raising the internal temperature to 105-110 ℃, and carrying out heat preservation reaction for 48 hours. The reaction solution was concentrated under reduced pressure to remove water, toluene was distilled, 42.0kg of methyl t-butyl ether was added to the residue, filtration was carried out, the methyl t-butyl ether filtrate was concentrated, 18.0kg of n-heptane was added to the residue, and pulping, filtration and drying were carried out to obtain 14.3kg of the compound of formula V as a white solid with a yield of 93.3%.1HNMR(400MHz，D2O)：δ(ppm)3.35～3.48(m，2H) (ii) a 2.06-2.19 (m, 4H). Preparation of compound I:
adding acetyl chloride (13.5kg) into a reaction kettle, starting stirring, continuously adding the compound of the formula V (5.00kg,34.7mol,1.0eq.), heating the reaction kettle to 135-145 ℃, and carrying out heat preservation reaction for 5-6 h. Concentrating the reaction liquid under reduced pressure to remove acetyl chloride, adding THF (9.0kg) into the concentrate, adding active carbon (0.50kg), heating to 60-70 ℃ for reflux, keeping the temperature and stirring for 2 hours, cooling and filtering, concentrating the filtrate to remove the solvent, adding methyl tert-butyl ether (3.0kg) into the remainder, cooling the reaction kettle to 0-5 ℃, cooling and crystallizing, filtering, and drying the filter cake to obtain 3.1kg of a compound shown in the formula I as a white solid with the yield of 70.9%.1HNMR(400MHz，DMSO，d6)：δ(ppm)3.49～3.53(m，2H)；2.50～2.60(m，2H)；2.18～2.25(m，2H)。
Example 2
Preparation of the compound of formula III:
methyl cyanoacetate (0.768kg,7.75mol,1.0eq.), acetonitrile (8.0kg) and methyl 2, 4-dibromobutyrate (2.4kg,9.3mol,1.2eq.) were added to the reaction kettle, and the stirring was started. Powdered potassium carbonate (2.7kg,19.4mol,2.5eq.) is added in portions with stirring, and the temperature is raised to 70-75 ℃ for reaction for 12 h. Filtering, concentrating the filtrate under reduced pressure to remove the solvent, adding 4.0kg of MTBE into the residue, washing with 1.0kg of 10% sodium chloride solution, drying and concentrating to obtain a crude product of the compound IV-1, carrying out reduced pressure distillation on the crude product by a vacuum pump (100-200 Pa), collecting fractions at 95-105 ℃ to obtain 1.20kg of a light yellow liquid of the compound IV-2, wherein the yield is 72.8%.
Preparation of a Compound of formula V:
adding the compound (2.0kg, 10.1mol, 1.0eq.) of the formula IV-2 and 18.7kg of process water into a reaction kettle, adding sodium hydroxide (2.02kg, 50.5mol, 5.0eq.) into the reaction kettle, starting stirring, raising the internal temperature to 90-100 ℃, and carrying out heat preservation reaction for 24 hours. The pH of the reaction solution is adjusted to 1-2 by concentrated hydrochloric acid, the reaction solution is decompressed and concentrated to remove water, toluene is distilled, 4.0kg of methyl tert-butyl ether is added into the residue, the filtration is carried out, the filtrate of the methyl tert-butyl ether is concentrated, 2.0kg of n-heptane is added into the residue for pulping, the filtration and the drying are carried out to obtain 1.34kg of the compound of the formula V which is a white-like solid, and the yield is 92.0%.
Preparation of compound I:
adding acetic anhydride (1.5kg) into a reaction kettle, starting stirring, continuously adding the compound of the formula V (0.50kg,3.47mol,1.0eq.), heating the temperature in the reaction kettle to 135-145 ℃, and carrying out heat preservation reaction for 20-24 h. And (2) carrying out reduced pressure concentration on the reaction liquid to remove acetic anhydride, adding THF (1.0kg) into the concentrate, adding activated carbon (50g), heating to 60-70 ℃ for reflux, carrying out heat preservation and stirring for 2h, cooling and filtering, concentrating the filtrate, adding methyl tert-butyl ether (0.4kg) into the residue, cooling the reaction kettle to 0-5 ℃, cooling and crystallizing, filtering, and drying the filter cake to obtain 297.5g of a white solid of the compound shown in the formula I, wherein the yield is 68.0%.1HNMR(400MHz，DMSO，d6)：δ(ppm)3.49～3.53(m，2H)；2.50～2.60(m，2H)；2.18～2.25(m，2H)。
Example 3
Preparation of the compound of formula III:
ethyl cyanoacetate (2.20kg,19.4mol,1.0eq.), acetonitrile (30.0kg) and methyl 2, 4-dibromobutyrate (5.5kg,21.34mol,1.1eq.) were added to the reaction kettle, and the stirring was started. Powdered cesium carbonate (15.8kg,48.5mol,2.5eq.) was added in portions with stirring, the temperature was raised to 60-65 ℃ for reaction for 6h, and the disappearance of the raw material was monitored by GC. Filtering, concentrating the filtrate under reduced pressure to remove the solvent, adding 10.0kg of MTBE into the residue, washing with 2.0kg of 10% sodium chloride water, drying and concentrating to obtain a crude product, carrying out reduced pressure distillation on the crude product by a vacuum pump (150-200 Pa), and collecting a fraction at 95-105 ℃ to obtain 3.05kg of a light yellow liquid serving as a compound of the formula IV-1 with the yield of 74.0%.
Preparation of a Compound of formula V:
adding the compound (2.25kg, 10.6mol, 1.0eq.) of the formula IV-1 and 4.0kg of process water into a reaction kettle, adding concentrated sulfuric acid (4.15kg, 42.4mol, 4.0eq.) into the reaction kettle, stirring, raising the internal temperature to 100-105 ℃, and carrying out heat preservation reaction for 48 hours. The reaction solution was concentrated under reduced pressure to remove water, toluene was evaporated with water, 4.0kg of methyl t-butyl ether was added to the residue, filtered, the filtrate was concentrated to remove the solvent, 2.0kg of n-heptane was added to the residue for pulping, filtered and dried to obtain 1.38kg of the compound of formula V as a white solid with a yield of 90.0%.
Preparation of a Compound of formula I:
phosphorus pentoxide (1.96kg,13.8mol,2.0eq.) and 7.0kg of 1, 4-dioxane were added into the reaction kettle, the stirring was started, the compound of formula V (1.0kg,6.94mol,1.0eq.) was continuously added, the temperature in the reaction kettle was raised to 90-100 ℃, and the reaction was maintained for 12 hours. LC monitors the disappearance of starting material. And (2) concentrating the reaction solution under reduced pressure, removing the solvent, adding 500g of methyl tert-butyl ether into the residue, cooling the reaction kettle to 0-5 ℃, cooling and crystallizing, filtering, and drying the filter cake to obtain 1.28kg of white solid with the yield of 75.0%.1HNMR(400MHz，DMSO，d6)：δ(ppm)3.49～3.53(m，2H)；2.50～2.60(m，2H)；2.18～2.25(m，2H)。
Claims (7)
1. A process for the preparation of a compound of formula I, comprising the steps of:
the method comprises the following steps: a compound of a formula II and a compound of a formula III are subjected to ring closing under the action of alkali 1 to prepare a compound of a formula IV;
step two: hydrolyzing the compound shown in the formula IV under the action of acid or alkali 2 to remove carboxyl to generate a compound shown in the formula V;
step three: the compound of the formula V is subjected to ring closing under the action of a dehydrating reagent to generate a compound of a formula I;
wherein R is methyl or ethyl.
2. The method of claim 1, wherein: in the first step, the base 1 is one or more selected from potassium carbonate, cesium carbonate, potassium tert-butoxide or sodium hydride; the reaction solvent is selected from one or more of acetonitrile, dioxane, glycol dimethyl ether or toluene.
3. The production method according to claim 1 or claim 2, characterized in that: in the first step, the molar ratio of the compound shown in the formula II to the compound shown in the formula III is 1: 1-1.2; the reaction temperature range is 70-90 ℃.
4. The method of claim 1, wherein: in the second step, the acid is hydrochloric acid or sulfuric acid; the alkali 2 is sodium hydroxide or potassium hydroxide.
5. The production method according to claim 1 or claim 4, characterized in that: in the second step, the molar ratio of the compound shown in the formula IV to the acid or alkali 2 is 1: 4-5; the reaction temperature range is 90-110 ℃.
6. The production method according to claim 1, characterized in that: in the third step, the dehydrating reagent is one or more selected from acetyl chloride, acetic anhydride, phosphorus pentoxide or trifluoroacetic anhydride.
7. The production method according to claim 1 or claim 6, characterized in that: in the third step, the molar ratio of the compound shown in the formula V to the dehydrating reagent is 1: 2-5; the reaction temperature range is 60-100 ℃.
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