CN113825750A - 作为sglt1抑制剂的葡糖苷类衍生物及其应用 - Google Patents

作为sglt1抑制剂的葡糖苷类衍生物及其应用 Download PDF

Info

Publication number
CN113825750A
CN113825750A CN202080025867.6A CN202080025867A CN113825750A CN 113825750 A CN113825750 A CN 113825750A CN 202080025867 A CN202080025867 A CN 202080025867A CN 113825750 A CN113825750 A CN 113825750A
Authority
CN
China
Prior art keywords
compound
reaction
pharmaceutically acceptable
isomer
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202080025867.6A
Other languages
English (en)
Other versions
CN113825750B (zh
Inventor
李翼
于涛
毛庆华
吴成德
陈曙辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medshine Discovery Inc
Original Assignee
Medshine Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medshine Discovery Inc filed Critical Medshine Discovery Inc
Publication of CN113825750A publication Critical patent/CN113825750A/zh
Application granted granted Critical
Publication of CN113825750B publication Critical patent/CN113825750B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

一种作为SGLT1抑制剂的葡糖苷类衍生物，及其在制备SGLT1抑制剂相关疾病的药物中的应用。具体公开了式(II)所示衍生化合物、其互变异构体或其药学上可接受的组合物。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN202080025867.6A 2019-03-29 2020-03-30 作为sglt1抑制剂的葡糖苷类衍生物及其应用 Active CN113825750B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201910251853 2019-03-29
CN2019102518535 2019-03-29
CN2019111049495 2019-11-13
CN201911104949 2019-11-13
CN2020101052511 2020-02-20
CN202010105251 2020-02-20
PCT/CN2020/082007 WO2020200153A1 (zh) 2019-03-29 2020-03-30 作为sglt1抑制剂的葡糖苷类衍生物及其应用

Publications (2)

Publication Number Publication Date
CN113825750A true CN113825750A (zh) 2021-12-21
CN113825750B CN113825750B (zh) 2022-07-12

Family

ID=72664696

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080025867.6A Active CN113825750B (zh) 2019-03-29 2020-03-30 作为sglt1抑制剂的葡糖苷类衍生物及其应用

Country Status (5)

Country Link
US (1) US20220153772A1 (zh)
EP (1) EP3950684B1 (zh)
JP (1) JP7210771B2 (zh)
CN (1) CN113825750B (zh)
WO (1) WO2020200153A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116322675A (zh) * 2020-09-27 2023-06-23 南京明德新药研发有限公司 葡糖苷类化合物的晶型及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104854096A (zh) * 2012-11-20 2015-08-19 莱西肯医药有限公司 钠葡萄糖协同转运蛋白1的抑制剂
CN106892948A (zh) * 2015-12-17 2017-06-27 广东东阳光药业有限公司 吡喃葡萄糖基衍生物及其在医药上的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5505741B2 (ja) * 2009-02-23 2014-05-28 大正製薬株式会社 Ｓｇｌｔ１阻害剤としての４−イソプロピルフェニルグルシトール化合物
EP3712147B8 (en) * 2018-01-05 2023-04-26 Shandong Danhong Pharmaceutical Co., Ltd. Sglts inhibitor and application thereof
WO2019185026A1 (zh) * 2018-03-30 2019-10-03 南京明德新药研发有限公司 作为SGLTs抑制剂的葡糖苷类衍生物及其应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104854096A (zh) * 2012-11-20 2015-08-19 莱西肯医药有限公司 钠葡萄糖协同转运蛋白1的抑制剂
CN106892948A (zh) * 2015-12-17 2017-06-27 广东东阳光药业有限公司 吡喃葡萄糖基衍生物及其在医药上的应用

Also Published As

Publication number Publication date
EP3950684B1 (en) 2024-03-20
EP3950684A1 (en) 2022-02-09
CN113825750B (zh) 2022-07-12
JP2022528237A (ja) 2022-06-09
US20220153772A1 (en) 2022-05-19
JP7210771B2 (ja) 2023-01-23
WO2020200153A1 (zh) 2020-10-08
EP3950684A4 (en) 2022-12-28

Similar Documents

Publication Publication Date Title
CN115698022B (zh) 五元杂芳并咪唑类化合物及其应用
CN111372930B (zh) 一种SGLTs抑制剂及其应用
CN111465598B (zh) 作为SGLTs抑制剂的葡糖苷类衍生物及其应用
CN115594734B (zh) 酮酰胺衍生物及其应用
CN114174282A (zh) 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用
CN114728967A (zh) 作为jak抑制剂的三并杂环类化合物及其应用
WO2022194221A1 (zh) 呋喃稠环取代的戊二酰亚胺类化合物
CN113227051A (zh) 用于视网膜疾病的化合物
CN113825750B (zh) 作为sglt1抑制剂的葡糖苷类衍生物及其应用
CN114585358B (zh) 一种SGLTs/DPP4抑制剂及其应用
CN114450289B (zh) 作为选择性btk激酶抑制剂的吡唑并吡啶类化合物
CN114026079B (zh) 一种sglt2/dpp4抑制剂及其应用
KR20200081456A (ko) Iap 억제제로서 유용한 smac 모방물 및 그 용도
CN113811530B (zh) 作为糜酶抑制剂的嘧啶酮类化合物及其应用
WO2020156568A1 (zh) 作为pd-l1免疫调节剂的氟乙烯基苯甲酰胺基化合物
CN113474318A (zh) 用作血浆激肽释放酶抑制剂的双环烷类化合物
CN113677339B (zh) Iap抑制剂与免疫检查点抑制剂的组合
TW202309013A (zh) 酮類衍生物
CN117940417A (zh) 卤素取代的哒嗪酮类化合物及其应用
CN117355515A (zh) 哌嗪衍生物及其应用
CN114746400A (zh) 用作选择性雄激素受体调节剂的化合物
CN115677601A (zh) 一种具有抗肿瘤活性的化合物及其用途
CN116462635A (zh) 一种吡嗪-1(2h)-2-氧代类化合物及其制备方法与应用
CN113474345A (zh) 作为ret抑制剂的含氮螺环衍生物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40060815

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant