CN113769041A

CN113769041A - A topical Chinese medicinal composition for treating gynecological inflammation, and its preparation method

Info

Publication number: CN113769041A
Application number: CN202111278322.9A
Authority: CN
Inventors: 吕向东
Original assignee: Zhejiang Yanghe Health Management Technology Co ltd
Current assignee: Zhejiang Yanghe Health Management Technology Co ltd
Priority date: 2021-10-30
Filing date: 2021-10-30
Publication date: 2021-12-10

Abstract

The invention provides an external traditional Chinese medicine composition for treating gynecological inflammation and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The external traditional Chinese medicine composition for treating gynecological inflammation comprises, by weight, 12-20 parts of fructus cnidii, 2-8 parts of caltrop, 3-8 parts of calcined oyster, 1.5-4 parts of caulis spatholobi, 0.8-2.2 parts of salvia miltiorrhiza, 1.5-1.8 parts of curcuma zedoary, 0.5-0.9 part of folium mori, 2.2-3.0 parts of fried cacumen biotae and 1-3 parts of liquorice. The invention also provides a preparation method of the external traditional Chinese medicine composition for treating gynecological inflammation. The external traditional Chinese medicine composition for treating gynecological inflammation has the advantages that the external traditional Chinese medicine composition for treating gynecological inflammation can effectively treat gynecological inflammation, can quickly relieve itching and sterilize, has no toxic or side effect, is convenient to use, has no recurrence, can effectively extract beneficial components in the raw materials by classifying and preparing the raw materials, and is simple in preparation method and convenient to popularize.

Description

A topical Chinese medicinal composition for treating gynecological inflammation, and its preparation method

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to an external traditional Chinese medicine composition for treating gynecological inflammation and a preparation method thereof.

Background

Gynecological inflammation is a common disease of women, mainly refers to inflammation of female reproductive organs, and specifically comprises female vulvitis, vaginitis, cervicitis, pelvic inflammation and the like. The common symptoms of gynecological inflammation are pruritus vulvae and vagina, and some local erosion, accompanied with burning pain, pain in urination, frequent urination, increase of vaginal secretion, red swelling and the like.

In particular, the symptoms are as follows:

vaginitis: clinically, the main clinical characteristics of the change of leucorrhea and itching and burning pain of vulvar ulcers are common pain, and symptoms such as pain in urination, urgent urination and the like can be caused when the urethra is infected.

Cervicitis: the main symptom is increased leucorrhea. Acute cervicitis with purulent leucorrhea with pain in the lower abdomen and lumbosacral area, or bladder irritation such as frequent micturition, urgent micturition, and painful urination. The chronic cervicitis leucorrhea is milky white sticky liquid or yellowish purulent.

Pelvic inflammation: the lower abdominal pain is accompanied by fever, and if the condition is serious, there may be chills, high fever, headache and poor appetite. The onset of menstrual period may cause increased menstrual volume and prolonged menstrual period, and the onset of non-menstrual period may cause increased leucorrhea. In the case of peritonitis, digestive symptoms such as nausea, vomiting, abdominal distension, diarrhea, etc. appear.

At present, the external medicine for treating gynecological inflammation is lotion or suppository, and is an antibacterial agent, and although the external medicine can be used for effectively stopping itching in a short time, the external medicine is easy to repeat after being stopped, and can promote the drug resistance of patients and increase the difficulty of subsequent treatment. Therefore, from the perspective of traditional Chinese medicine, it is necessary to develop an external traditional Chinese medicine composition for treating gynecological inflammation, so as to reduce the frequency of repeated attack and reduce the drug resistance of patients.

Disclosure of Invention

The invention aims to provide an external traditional Chinese medicine composition for treating gynecological inflammation, which can effectively treat gynecological inflammation, can quickly relieve itching and sterilize, has no toxic or side effect, is convenient to use and has no recurrence.

The invention also aims to provide a preparation method of the external traditional Chinese medicine composition for treating gynecological inflammation, which is simple in preparation method, low in cost and convenient to popularize.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On the one hand, the embodiment of the application provides an external traditional Chinese medicine composition for treating gynecological inflammation, which comprises the following raw materials, by weight, 12-20 parts of fructus cnidii, 2-8 parts of caltrop, 3-8 parts of calcined oyster, 1.5-4 parts of caulis spatholobi, 0.8-2.2 parts of salvia miltiorrhiza, 1.5-1.8 parts of curcuma zedoary, 0.5-0.9 part of folium mori, 2.2-3.0 parts of fried cacumen biotae and 1-3 parts of liquorice.

On the other hand, the embodiment of the present application provides a preparation method of the external traditional Chinese medicine composition for treating gynecological inflammation, which includes the following steps: crushing fructus cnidii, caltrop, calcined oyster shell, caulis spatholobi, salvia miltiorrhiza, curcuma zedoary, mulberry leaf, fried cacumen biotae and liquorice, adding water, refluxing and extracting for 3-5 times, 1-2 h each time, combining water decoction, concentrating into an extract with the relative density of 1.12-1.35, precipitating the extract with ethanol, collecting supernatant, concentrating and drying to obtain medicinal powder; pulverizing herba Menthae into powder, extracting at 50 deg.C under 9MPa with carbon dioxide flow of 25L/h in an extraction kettle until there is no oil drop, and collecting oleum Menthae; mixing the medicinal powder with solvent, adding oleum Menthae Dementholatum, antiseptic and penetration enhancer, mixing, and filtering with 0.22 μm filter membrane to obtain the topical Chinese medicinal composition.

In summary, compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

the invention provides an external traditional Chinese medicine composition for treating gynecological inflammation, which is prepared from common cnidium fruit and puncturevine fruit, and is used for eliminating dampness and dispelling wind, killing parasites and relieving itching, calcined oyster shell and suberect spatholobus stem are used for regulating menstruation and relieving pain, relaxing tendons and activating collaterals, red sage root and zedoary are used for activating blood and removing stasis, clearing the channels and relieving pain, promoting qi circulation and breaking blood, mulberry leaf and fried cacumen biotae are used for dispelling wind and heat, liquorice is used for relieving spasm and relieving pain, and the medicines are harmonized. The traditional Chinese medicine composition for external use for treating gynecological inflammation has the advantages of rapid itching relieving, no toxic or side effect, convenient use and no recurrence.

According to the preparation method of the external traditional Chinese medicine composition for treating gynecological inflammation, provided by the invention, the effective components in the traditional Chinese medicines are fully collected by decoction, the peppermint oil is extracted by a supercritical carbon dioxide technology, and the peppermint oil is prepared by classification and then mixed, so that the finally obtained external traditional Chinese medicine composition has a better effect.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

Fructus cnidii: is dried mature fruit of Cnidium monnieri (L.) Cuss. Collected in summer and autumn when the fruits are ripe, removed of impurities and dried in the sun. [ PROPERTIES AND DENTAL GUIDANCE ] is pungent, bitter and warm; has little toxicity. It enters kidney meridian. [ FUNCTIONS ] can eliminate dampness, dispel pathogenic wind, kill parasites, relieve itching, warm kidney and strengthen yang. Can be used for treating pruritus vulvae, leukorrhagia, eczema, pruritus, lumbago due to damp arthralgia, sexual impotence due to kidney deficiency, and infertility due to cold womb.

Caltrop fruit: is dried mature fruit of Tribulus terrestris L. Harvesting plants when fruit is mature in autumn, drying in the sun, digging down the fruit, and removing impurities. [ PROPERTIES AND DENTAL GUIDANCE ] is pungent, bitter and slightly warm; has little toxicity. It enters liver meridian. [ FUNCTIONS AND INDICATIONS ] can calm the liver, relieve depression, promote blood circulation, dispel pathogenic wind, improve eyesight, and relieve itching. Can be used for treating headache, vertigo, distending pain in chest and hypochondrium, milk retention, mammary abscess, conjunctival congestion, nebula, rubella and pruritus.

Calcining oysters: the shell of Ostrea gigas Thunberg, Ostrea talienhanensis Crosse, or Ostrea rivularis Gould of Ostrea gigas of Ostrea of family Ostreatia. Fishing, fleshing, cleaning and drying in the sun all the year round. [ PROPERTIES, WESTERN AND GUIJING ] is salty and slightly cold. It enters liver, gallbladder and kidney meridians. [ FUNCTIONS AND INDICATIONS ] can tranquilize the mind, subdue yang, tonify yin, soften hardness and dissipate nodulation. Can be used for treating palpitation, insomnia, vertigo, tinnitus, scrofula, subcutaneous nodule, and abdominal mass. Calcined oyster shell astringes and relieves pain. Can be used for treating spontaneous perspiration, night sweat, spermatorrhea, metrorrhagia, leukorrhagia, gastralgia, and acid regurgitation.

Caulis spatholobi: is dried rattan of Spatholobus suberectus Dunn of Leguminosae. Collected in autumn and winter, removed branches and leaves, sliced and dried in the sun. [ PROPERTIES AND WEIGHT GUIDING GEN ] is bitter, sweet and warm. It enters liver and kidney meridians. [ FUNCTIONS AND INDICATIONS ] can promote blood circulation, tonify blood, regulate menstruation, relieve pain, relax tendons and activate collaterals. Can be used for treating menoxenia, dysmenorrhea, amenorrhea, rheumatalgia, numbness, paralysis, and sallow complexion due to blood deficiency.

Red sage root: is dried root and rhizome of Salvia Miltiorrhiza bge. Collected in spring and autumn, removed of silt and dried. [ PROPERTIES, WESTERN AND GUIJING ] is bitter and slightly cold. It enters heart and liver meridians. [ FUNCTIONS AND INDICATIONS ] can promote blood circulation, dispel blood stasis, dredge meridians, relieve pain, clear away the heart-fire, relieve restlessness, cool blood and cure carbuncle. Can be used for treating thoracic obstruction, cardialgia, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.

Zedoary turmeric: is dried rhizome of Curcuma zedoaria Phaeocaulis Val, Curcuma zedoaria kuuangsiensis S.G.LeeetC.F.Liang or Curcuma wenyuma wenyujin Y.H.Chenet C.Ling. [ PROPERTIES AND WEIGHT GUIDING GEN ] is pungent, bitter and warm. It enters liver and spleen meridians. [ FUNCTIONS AND INDICATIONS ] can promote the circulation of qi, remove blood stasis, eliminate stagnation and alleviate pain. Can be used for treating abdominal mass, amenorrhea due to blood stasis, thoracic obstruction, heart pain, and pain due to food stagnation.

Mulberry leaf: is dried leaf of Morus albal. After blooming, harvesting, removing impurities and drying in the sun. [ PROPERTIES AND WESTERN CHANNELS ] is sweet, bitter and cold. It enters lung and liver meridians. Disperse wind-heat, clear lung-heat and moisten dryness, clear liver and improve vision. Can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight.

Parching cacumen biotae: is dried shoot and leaf of Franco of Platylladus orientalis (L.) of Cupressaceae. Collected in summer and autumn mostly and dried in the shade. [ PROPERTIES AND DENTAL CHANNEL tropism ] is bitter, astringent and cold. It enters lung, liver and spleen meridians. [ FUNCTIONS AND INDICATIONS ] can remove heat from the blood, stop bleeding, resolve phlegm, relieve cough, promote hair growth and blacken hair. Can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, cough due to lung heat, alopecia due to blood heat, and premature gray hair.

Licorice root: is dried root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat, or Glycyrrhiza glabra L. Collected in spring and autumn, removed fibrous root, and dried in the sun. [ PROPERTIES AND FLAVOUR AND GUIJING ] is sweet and neutral. It enters heart, lung, spleen and stomach meridians. [ FUNCTIONS AND INDICATIONS ] can tonify spleen and qi, clear away heat and toxic materials, dispel phlegm and stop cough, relieve spasm and alleviate pain, and harmonize the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

In some embodiments of the present invention, the external traditional Chinese medicine composition for treating gynecological inflammation further comprises 2 to 6 parts by weight of mint.

Mint: is dried aerial parts of Mentha haplocalyx Briq. of Labiatae. When stems and leaves flourish or flowers bloom to three rounds in summer and autumn, the plants are harvested and cut in parts on a sunny day, and dried in the sun or in the shade. Pungent and cool. It enters lung and liver meridians. Disperse wind-heat, clear heat and improve eyesight, relieve sore throat, promote eruption, soothe liver and move qi. Can be used for treating wind-heat type common cold, headache, conjunctival congestion, pharyngitis, aphtha, rubella, measles, and chest and hypochondrium swelling.

In some embodiments of the present invention, the external traditional Chinese medicine composition for treating gynecological inflammation is in a spray form.

In some embodiments of the present invention, the external traditional Chinese medicine composition for treating gynecological inflammation further comprises 2-6 wt% of a penetration enhancer.

In some embodiments of the present invention, in the external traditional Chinese medicine composition for treating gynecological inflammation, the penetration enhancer is one or more of glycerin, propylene glycol and butylene glycol.

In some embodiments of the present invention, the external traditional Chinese medicine composition for treating gynecological inflammation further comprises 0.1 to 0.4 wt% of a preservative.

In some embodiments of the present invention, in the above external traditional Chinese medicine composition for treating gynecological inflammation, the preservative is one or more of benzyl alcohol, imidazolidinyl urea, parabens and p-hydroxybenzoic acid.

In some embodiments of the present invention, the pH of the spray is 3.8 to 4.4 in the external traditional Chinese medicine composition for treating gynecological inflammation.

On the other hand, the embodiment of the present application provides a preparation method of the external traditional Chinese medicine composition for treating gynecological inflammation, which includes the following steps:

crushing fructus cnidii, caltrop, calcined oyster shell, caulis spatholobi, salvia miltiorrhiza, curcuma zedoary, mulberry leaf, fried cacumen biotae and liquorice, adding water, refluxing and extracting for 3-5 times, 1-2 h each time, combining water decoction, concentrating into an extract with the relative density of 1.12-1.35, precipitating the extract with ethanol, collecting supernatant, concentrating and drying to obtain medicinal powder; pulverizing herba Menthae into powder, extracting at 50 deg.C under 9MPa with carbon dioxide flow of 25L/h in an extraction kettle until there is no oil drop, and collecting oleum Menthae; mixing the medicinal powder with solvent, adding oleum Menthae Dementholatum, antiseptic and penetration enhancer, mixing, and filtering with 0.22 μm filter membrane to obtain the topical Chinese medicinal composition.

In some embodiments of the present invention, in the preparation method of the external traditional Chinese medicine composition for treating gynecological inflammation, the reflux extraction temperature is 70 to 75 ℃, the volume percentage of ethanol in the ethanol solution for alcohol precipitation is 50 to 80%, and the alcohol precipitation time is 24 to 36 hours.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The present invention aims to provide an external traditional Chinese medicine composition for treating gynecological inflammation, which is prepared by the following steps:

the method comprises the following steps: crushing fructus Cnidii 12g, fructus Tribuli 8g, Concha Ostreae preparata 3g, caulis Spatholobi 3g, Saviae Miltiorrhizae radix 1.2g, Curcumae rhizoma 1.6g, folium Mori 0.7g, parched folium Platycladi 3.0g and Glycyrrhrizae radix 2g, adding water, reflux-extracting for 3 times, each time for 1 hr, reflux-extracting at 70 deg.C; combining the water decoctions, and concentrating to obtain an extract with the relative density of 1.12-1.35;

step two: then sequentially passing the extract through 50 vol%, 60 vol%, 70 vol% and 80 vol% ethanol for 24h each time, collecting supernatant, concentrating and drying to obtain medicinal powder;

step three: pulverizing herba Menthae into powder, extracting at 50 deg.C under 9MPa with carbon dioxide flow of 25L/h in an extraction kettle until there is no oil drop, and collecting oleum Menthae;

step four: mixing the medicinal powder with a solvent, wherein the solvent comprises water and butanediol, the dosage ratio of the water to the butanediol is 100:0.2, adding peppermint oil, a preservative and a permeation aid, mixing, adjusting the pH to 3.8-4.4, and filtering with a 0.22-micron filter membrane to obtain the external traditional Chinese medicine composition, wherein the medicinal powder accounts for 5 wt%, the permeation aid accounts for 2 wt%, the preservative accounts for 0.1 wt%, and the balance is the solvent.

Example 2

the method comprises the following steps: crushing 15g of fructus cnidii, 2g of caltrop, 7g of calcined oyster, 1.5g of caulis spatholobi, 1.8g of salvia miltiorrhiza, 1.7g of curcuma zedoary, 0.9g of mulberry leaf, 2.2g of fried cacumen biotae and 3g of liquorice, adding water, and carrying out reflux extraction for 3 times, 1 hour each time, wherein the reflux extraction temperature is 70 ℃; combining the water decoctions, and concentrating to obtain an extract with the relative density of 1.12-1.35;

step four: mixing the medicinal powder with a solvent, wherein the solvent comprises water and butanediol, the dosage ratio of the water to the butanediol is 100:0.2, adding peppermint oil, a preservative and a permeation enhancer, mixing, adjusting the pH to 3.8-4.4, and filtering with a 0.22-micron filter membrane to obtain the external traditional Chinese medicine composition, wherein the medicinal powder accounts for 5 wt%, the permeation enhancer accounts for 3 wt%, the preservative accounts for 0.2 wt%, and the balance is the solvent.

Example 3

the method comprises the following steps: crushing 18g of fructus cnidii, 4g of caltrop, 5g of calcined oyster, 4g of caulis spatholobi, 0.8g of salvia miltiorrhiza, 1.5g of curcuma zedoary, 0.8g of mulberry leaf, 2.8g of fried cacumen biotae and 2.5g of liquorice, adding water, and carrying out reflux extraction for 3 times, 1 hour each time, wherein the reflux extraction temperature is 70 ℃; combining the water decoctions, and concentrating to obtain an extract with the relative density of 1.12-1.35;

step four: mixing the medicinal powder with a solvent, wherein the solvent comprises water and butanediol, the dosage ratio of the water to the butanediol is 100:0.2, adding peppermint oil, a preservative and a permeation enhancer, mixing, adjusting the pH to 3.8-4.4, and filtering with a 0.22-micron filter membrane to obtain the external traditional Chinese medicine composition, wherein the medicinal powder accounts for 5 wt%, the permeation enhancer accounts for 5 wt%, the preservative accounts for 0.4 wt%, and the balance is the solvent.

Example 4

the method comprises the following steps: crushing 20g of fructus cnidii, 6g of caltrop, 8g of calcined oyster, 3.5g of caulis spatholobi, 2.2g of salvia miltiorrhiza, 1.8g of curcuma zedoary, 0.5g of mulberry leaf, 2.4g of fried cacumen biotae and 1.5g of liquorice, adding water, and carrying out reflux extraction for 3 times, 1 hour each time, wherein the reflux extraction temperature is 70 ℃; combining the water decoctions, and concentrating to obtain an extract with the relative density of 1.12-1.35;

step four: mixing the medicinal powder with a solvent, wherein the solvent comprises water and butanediol, the dosage ratio of the water to the butanediol is 100:0.2, adding peppermint oil, a preservative and a permeation enhancer, mixing, adjusting the pH to 3.8-4.4, and filtering with a 0.22-micron filter membrane to obtain the external traditional Chinese medicine composition, wherein the medicinal powder accounts for 5 wt%, the permeation enhancer accounts for 6 wt%, the preservative accounts for 0.4 wt%, and the balance is the solvent.

Example 5

the method comprises the following steps: crushing fructus Cnidii 15g, fructus Tribuli 5g, Concha Ostreae preparata 5g, caulis Spatholobi 3g, Saviae Miltiorrhizae radix 1.5g, Curcumae rhizoma 1.6g, folium Mori 0.7g, parched folium Platycladi 2.5g and Glycyrrhrizae radix 2g, adding water, and reflux-extracting for 3 times, each time for 1 hr at reflux-extracting temperature of 70 deg.C; combining the water decoctions, and concentrating to obtain an extract with the relative density of 1.12-1.35;

step four: mixing the medicinal powder with a solvent, wherein the solvent comprises water and butanediol, the dosage ratio of the water to the butanediol is 100:0.2, adding peppermint oil, a preservative and a permeation enhancer, mixing, adjusting the pH to 3.8-4.4, and filtering with a 0.22-micron filter membrane to obtain the external traditional Chinese medicine composition, wherein the medicinal powder accounts for 5 wt%, the permeation enhancer accounts for 6 wt%, the preservative accounts for 0.1 wt%, and the balance is the solvent.

Example 6

step two: then sequentially passing the extract through 50 vol%, 60 vol%, 70 vol% and 80 vol% ethanol for 36h each time, collecting supernatant, concentrating and drying to obtain medicinal powder;

Example 7

step two: then sequentially passing the extract through 50 vol%, 60 vol%, 70 vol% and 80 vol% ethanol for 48h each time, collecting supernatant, concentrating and drying to obtain medicinal powder;

Example 8

the method comprises the following steps: crushing fructus Cnidii 15g, fructus Tribuli 5g, Concha Ostreae preparata 5g, caulis Spatholobi 3g, Saviae Miltiorrhizae radix 1.5g, Curcumae rhizoma 1.6g, folium Mori 0.7g, parched folium Platycladi 2.5g and Glycyrrhrizae radix 2g, adding water, and reflux-extracting for 3 times, each time for 2 hr at reflux-extracting temperature of 70 deg.C; combining the water decoctions, and concentrating to obtain an extract with the relative density of 1.12-1.35;

Example 9

step two: sequentially adding 50 vol% and 80 vol% ethanol into the extract, collecting supernatant, concentrating, and drying to obtain medicinal powder each time for 48 hr;

The antiseptic used in the external traditional Chinese medicine composition for treating gynecological inflammation provided in embodiments 1 to 9 includes one or more of benzyl alcohol, imidazolidinyl urea, parabens and p-hydroxybenzoic acid.

Examples of effects

50 patients suffering from gynecological inflammation are collected and divided into 10 groups, each group is numbered as 1-10, the external traditional Chinese medicine composition for treating gynecological inflammation provided by the embodiments 1-9 is used correspondingly, and the existing washing medicament for treating gynecological inflammation on the market is used in 10 groups. The use cases are all used twice daily, and the use results are as follows:

TABLE 1

Group of	Number of itching-relieving uses	The cure rate is%	Recurrence within one year
				1	5	100
2	4	100	0
				3	5	100	0
4	3	100	0
				5	3	100	0
6	3	100	0
				7	2	100	0
8	2	100	0
				9	3	100	0
Control group	8	80％	4

As can be seen from Table 1, the control group used the existing washing liquid and required 4 days to relieve itching, but the external traditional Chinese medicine composition for treating gynecological inflammation provided by the invention can relieve itching after being used twice at the fastest speed, and the cure rate can basically reach 100%, and no recurrence occurs. In addition, in examples 1 to 5, the difference is mainly in the drug ratio, so it can be seen that different drug ratios affect the therapeutic effect of the composition, so that the effect of the composition provided in example 5 is the best. The main difference between the embodiments 5 to 9 lies in the difference between the preparation methods, and relatively speaking, the contents of the drugs in the composition can be significantly increased, the drug effect can be improved, and the itching can be rapidly relieved by increasing the reflux times and the alcohol extraction time in the embodiments 7 and 8.

In summary, the external traditional Chinese medicine composition for treating gynecological inflammation provided by the embodiment of the invention has the following beneficial effects:

the external traditional Chinese medicine composition for treating gynecological inflammation provided by the invention has the advantages that the common cnidium fruit, the caltrop, the calcined oyster shell, the suberect spatholobus stem, the salvia miltiorrhiza, the zedoary, the mulberry leaf, the fried cacumen biotae and the liquorice are reasonably mixed, so that the treatment effect of the external traditional Chinese medicine composition for treating gynecological inflammation is superior to that of the existing cleaning agent, and the recurrence rate is low.

In the formula, common cnidium fruit and tribulus fruit are used for eliminating dampness and dispelling wind, killing parasites and relieving itching, calcined oyster shell and suberect spatholobus stem are used for regulating menstruation and relieving pain, relaxing tendons and activating collaterals, red sage root and zedoary are used for activating blood and removing stasis, clearing channels and relieving pain, promoting qi circulation and breaking blood, mulberry leaf and stir-fried cacumen biotae are used for dispelling wind and heat from the body, and liquorice is used for relieving spasm and relieving pain and harmonizing the medicines. The traditional Chinese medicine composition for external use for treating gynecological inflammation can quickly relieve itching and has no recurrence. In addition, although the present application mainly provides the examples as the spray, the composition is not limited to be used only for the spray, and may be any other existing dosage form.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. An external traditional Chinese medicine composition for treating gynecological inflammation is characterized by comprising, by weight, 12-20 parts of fructus cnidii, 2-8 parts of caltrop, 3-8 parts of calcined oyster, 1.5-4 parts of caulis spatholobi, 0.8-2.2 parts of salvia miltiorrhiza, 1.5-1.8 parts of curcuma zedoary, 0.5-0.9 part of folium mori, 2.2-3.0 parts of fried cacumen biotae and 1-3 parts of liquorice.

2. The external traditional Chinese medicine composition for treating gynecological inflammation according to claim 1, further comprising 2-6 parts by weight of mint.

3. The external traditional Chinese medicine composition for treating gynecological inflammation according to claim 2, wherein the dosage form of the external traditional Chinese medicine composition is spray.

4. The external traditional Chinese medicine composition for treating gynecological inflammation according to claim 3, further comprising 2-6 wt% of a penetration enhancer.

5. The topical Chinese medicinal composition for the treatment of gynecological inflammation according to claim 4, wherein the penetration enhancer is one or more of glycerol, propylene glycol and butylene glycol.

6. The external traditional Chinese medicine composition for treating gynecological inflammation according to claim 4, further comprising 0.1-0.4 wt% of a preservative.

7. The topical Chinese medicinal composition for treating gynecological inflammation according to claim 6, wherein the preservative comprises one or more of benzyl alcohol, imidazolidinyl urea, parabens and p-hydroxybenzoic acid.

8. The external traditional Chinese medicine composition for treating gynecological inflammation according to any one of claims 3 to 7, wherein the pH value of the spray is 3.8 to 4.4.

9. A method for preparing the topical Chinese medicinal composition for treating gynecological inflammation according to any one of claims 3 to 8, comprising the following steps:

crushing fructus cnidii, caltrop, calcined oyster shell, caulis spatholobi, salvia miltiorrhiza, curcuma zedoary, mulberry leaf, fried cacumen biotae and liquorice, adding water, refluxing and extracting for 3-5 times, 1-2 h each time, combining water decoction, concentrating into an extract with the relative density of 1.12-1.35, precipitating the extract with ethanol, collecting supernatant, concentrating and drying to obtain medicinal powder;

pulverizing herba Menthae into powder, extracting at 50 deg.C under 9MPa with carbon dioxide flow of 25L/h in an extraction kettle until there is no oil drop, and collecting oleum Menthae;

mixing the medicinal powder with solvent, adding oleum Menthae Dementholatum, antiseptic and penetration enhancer, mixing, and filtering with 0.22 μm filter membrane to obtain the topical Chinese medicinal composition.

10. The preparation method according to claim 9, wherein the reflux extraction temperature is 70-75 ℃, the volume percentage of ethanol in the ethanol solution for alcohol precipitation is 50-80%, and the alcohol precipitation time is 24-36 h.