CN113769029B

CN113769029B - Medicinal and edible herbal composition for improving intestinal absorption and immune function

Info

Publication number: CN113769029B
Application number: CN202111176126.0A
Authority: CN
Inventors: 谷晓红; 刘铁钢; 于河; 白辰; 黄羚; 董斐; 马雪颜
Original assignee: Beijing University of Chinese Medicine
Current assignee: Beijing University of Chinese Medicine
Priority date: 2021-10-09
Filing date: 2021-10-09
Publication date: 2023-01-17
Anticipated expiration: 2041-10-09
Also published as: CN113769029A

Abstract

The application belongs to the technical field of medicines, and particularly relates to a medicinal and edible herbal composition for improving intestinal absorption and immune functions. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 3 to 10 parts of dandelion, 3 to 10 parts of hawthorn, 3 to 10 parts of endothelium corneum gigeriae galli, 3 to 10 parts of malt, 3 to 10 parts of radish seed, 2 to 6 parts of seville orange flower and 3 to 10 parts of tuckahoe. The pharmacological experiment result shows that: the maintenance of the medicinal and edible herbal composition on goblet cells and epithelial cells shows that the medicinal and edible herbal composition can effectively improve the absorption function and the immune function of intestinal tracts.

Description

Medicinal and edible herbal composition for improving intestinal absorption and immune function

Technical Field

The application belongs to the technical field of medicines, and particularly relates to a medicinal and edible herbal composition for improving intestinal absorption and immune functions.

Background

The gastrointestinal health of modern people is influenced by irregular diet under high living pressure, unreasonable dietary structure caused by dependence on takeout and spicy eating, bad living habits such as physical overdraft, abuse of broad-spectrum antibiotics, food intake containing complex additives, pollutants in the natural environment (contact of toxic chemical substances, pesticide residues in soil, and excessive particulate matters in the atmosphere), and the like.

The gastrointestinal diseases are the most common diseases at present, the total incidence rate accounts for about 20% of the population, and the theory of 'ten nine stomach diseases' is provided in China. If a person cares about maintaining his gastrointestinal health, the disease is averagely developed over 800 times in a lifetime, and the health cost is a small amount. Gastrointestinal health is important to both the physical health of individuals and the harmonious development of society.

Gastrointestinal health refers to the normal physiological functions of the gastrointestinal tract including digestion, absorption and secretion, and immune function. Traditional Chinese medicine pays attention to gastrointestinal health, and ancient people indicate that the spleen and the stomach are the acquired root. The food can be interpreted by modern scientific language as food intake, transportation and digestion of the gastrointestinal tract, nutrient absorption and waste excretion, and the food is subjected to a series of complex digestion and decomposition processes in the gastrointestinal tract to become small molecular substances which are absorbed by the intestinal tract and processed by the liver to become in-vivo substances for the utilization of the tissues of the whole body. The digestive decomposition of food components in the gastrointestinal tract requires the participation of enzymatic reactions of hydrolases secreted by the pancreas and the gastrointestinal glands, bile secreted by the liver, enterobacterial enzymes, and the like. 70-80% of the human immune system is distributed in or around the intestinal tract, and modern studies have confirmed that the micro-ecology of the gastrointestinal tract plays an important role in regulating the immune system. The gastrointestinal tract is distributed with a large number of flora that constitute the micro-ecology of the gastrointestinal tract. The pre-cause of the dysfunction of the gastrointestinal tract is the disruption of the microecological balance of the gastrointestinal tract. The intestinal tract of a healthy human body is communicated with the outside, and a large number of microorganisms inhabit in the intestinal tract, the species and number of which are relatively stable and balanced when the human body is in a healthy state, are called normal flora or native flora, which are indispensable components in the internal environment of the body, and most of which form a symbiotic relationship with the human body in a long-term co-evolution process. On one hand, the human body selectively allows certain microorganisms to be planted in the intestinal tract and provides a proper inhabitation environment for the microorganisms; on the other hand, the microorganisms and the metabolites thereof promote the perfection and influence of the intestinal mucosa immune function and participate in various metabolic functions of the human body. The microecological state of the human gastrointestinal tract can reflect the health state of the gastrointestinal tract function to a certain extent. Disturbances of gastrointestinal tract function are the main cause of gastrointestinal tract organ pathology.

The traditional Chinese medicine and the western medicine have respective treatment advantages in the aspects of regulating the gastrointestinal function and treating the gastrointestinal diseases. Modern medicine suffers from the drawback that it is only effective in treating certain gastrointestinal disease conditions, for example, gastrointestinal distress in the face of helicobacter pylori infection is simply bactericidal. The traditional Chinese medicine treatment is usually determined according to syndrome differentiation and typing, has an overall treatment effect on improving the gastrointestinal tract function, and has the characteristics of pertinence, individuation and comprehensiveness. Especially, the traditional Chinese medicine treatment has the effect of relieving the gastrointestinal symptoms of modern medical stranded inadequacy. Taking functional dyspepsia which is common clinically and has no special treatment effect in modern medicine as an example, the traditional Chinese medicine divides the functional dyspepsia into a liver qi attacking stomach type, a diet stagnation type, a spleen and stomach weakness type, cold and heat mutual combination and a qi non-rising type, summarizes symptom signs as gastrointestinal motility dysfunction, choking gag on the upper part, distending pain in the stomach and a constipation on the lower part; if stomach qi does not descend or rise, belching, acid regurgitation, vomiting, heartburn, etc. can occur; spleen qi failing to ascend and descend causes sinking of middle qi, resulting in a sinking and distending stomach, a poor appetite and early fullness, and constipation. Through the methods of soothing liver, regulating qi, relieving stagnation and relieving stuffiness, promoting digestion, relieving stagnation, harmonizing stomach and lowering adverse qi, strengthening spleen, tonifying qi, harmonizing stomach and eliminating dampness.

Early basic prompts of the scientific research team indicate that gastrointestinal tract health is closely related to human immunity, and gastrointestinal tract flora disorder can cause susceptibility to upper respiratory tract infection. The upper respiratory tract infection is caused by virus and bacteria invading human body, and when virus and bacteria invade human body, the immune cells such as lymphocytes and macrophages of the human body are actively mobilized to resist and phagocytose the foreign invaders, so that the course of disease is shortened. 70-80% of human immune system is distributed in or around intestinal tract, and gastrointestinal tract dysfunction affects systemic immunity. When the viruses exceed the killing ability of lymphocytes and macrophages, the body is invaded by viruses and bacteria. The occurrence of the recurrent respiratory tract infection is directly related to the immunity of the organism, the disease resistance of the body is not strong, and the body cannot resist external pathogenic bacteria, so the recurrent respiratory tract infection is easy to occur.

Through literature search and retrospective review, the traditional Chinese medicine means for treating gastrointestinal diseases have a plurality of schemes and means, and a plurality of classic formulas of the Chinese medicine means are not lacked. For example, huoxiang Zhengqi pills, which are well known by common people, are commonly used for treating gastrointestinal diseases. The traditional Chinese medicine compositions are found to have certain unsafe factors, are still exemplified by the Huoxiang Zhengqi pills, and the common dosage form of the Huoxiang Zhengqi pills is Huoxiang Zhengqi liquid which contains 40 to 50 percent of alcohol and is not suitable for children and drivers. The pinellia ternate which is one of the components still has the problem of small toxicity after the dosage form improvement, and has challenges in clinical popularization and application and international trade barrier breakthrough. In addition, these classic traditional Chinese medicine compositions have pain spots which are caused by improper medication after being misused as OTC Chinese patent medicine. The traditional Chinese medicine composition has strong curative effect, namely, the traditional Chinese medicine composition has strong medicinal potency, and when the traditional Chinese medicine composition is used correctly, the effect is remarkable, and when the traditional Chinese medicine composition is not used properly, obvious side effects are easy to occur.

The invention solves the pain points and provides a medicinal and edible herbal composition. Consisting of a herbal material meeting the list of notifications about the management of further regulated health food materials (list of articles that are both food and drugs). Su Wen, wu Chang Zheng Da Lun (plain questions and five often political affairs) considers that "the disease is treated by toxic pathogen, and six of them are removed; treating diseases with common toxicity, seven of them are removed; treating diseases with small toxicity, and removing eight of the medicines; no toxicity for curing diseases, nine of which are eliminated; the cereal, meat, fruit and vegetable are eaten thoroughly. The Chinese medicament has the advantages of high efficiency and safety, is the basis of imported products (both medicaments and foods), and has great development potential.

Disclosure of Invention

The invention aims to provide a medicinal and edible herbal composition for improving intestinal absorption and immune function. The composition can improve gastrointestinal tract function, maintain gastrointestinal tract health, and solve the problem of obvious side effect of the traditional Chinese medicine composition for improving gastrointestinal tract function.

A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 3 to 10 parts of dandelion, 3 to 10 parts of hawthorn, 3 to 10 parts of endothelium corneum gigeriae galli, 3 to 10 parts of malt, 3 to 10 parts of radish seed, 2 to 6 parts of seville orange flower and 3 to 10 parts of poria cocos.

Preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 5 parts of dandelion, 5 parts of hawthorn, 5 parts of endothelium corneum gigeriae galli, 5 parts of malt, 5 parts of radish seed, 3 parts of seville orange flower and 5 parts of poria cocos.

Or, preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 3 parts of dandelion, 3 parts of hawthorn, 3 parts of endothelium corneum gigeriae galli, 3 parts of malt, 3 parts of radish seed, 2 parts of seville orange flower and 3 parts of poria cocos.

Or, preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 10 parts of dandelion, 10 parts of hawthorn, 10 parts of endothelium corneum gigeriae galli, 10 parts of malt, 10 parts of radish seed, 6 parts of seville orange flower and 10 parts of poria cocos.

Or, preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 6 parts of dandelion, 6 parts of hawthorn, 6 parts of endothelium corneum gigeriae galli, 6 parts of malt, 6 parts of radish seed, 4 parts of seville orange flower and 6 parts of poria cocos.

Or, preferably, the medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 9 parts of dandelion, 9 parts of hawthorn, 9 parts of endothelium corneum gigeriae galli, 9 parts of malt, 9 parts of radish seed, 6 parts of seville orange flower, 9 parts of poria cocos and 9 parts of momordica grosvenori.

The proportion of the weight proportion is obtained by scientific screening, and for special patients, such as severe or mild patients, obese patients or lean patients, the proportion of the components can be correspondingly adjusted, the increase or decrease is not more than 100 percent, and the drug effect is basically unchanged.

The weight parts of the above drugs, in g, are usually 1 dose.

The dosage form of the herbal composition is oral preparation. Preferably: decoction, extract, powder, chinese medicinal granule, decoction, distillate, pill, powder, unguent, pellet, tablet, lozenge, colloid, yeast, dripping pill, soft capsule, superfine powder, and colloid. More preferably granules and decoctions.

When the decoction is prepared, the method comprises the following steps: cleaning the above Chinese medicinal materials, soaking for one hour, decocting with water, boiling with strong fire, decocting with slow fire for half an hour, and removing residue. One dose is taken in the morning and at night. The composition is also suitable for infants. 1/6 of adult for newborn, 1/3-1/2 of adult for infant, 2/3 of adult for infant and toddler, and adult for school-age children.

The medicine and food homologous herbal and edible composition for improving intestinal absorption and immune function is applied to preparation of medicines for treating gastrointestinal heat accumulation syndrome, and symptoms of poor defecation habit caused by poor intestinal absorption, dyspepsia, abdominal distension and pain and the like caused by low immune function are shown.

In the medicinal and edible herbal composition for improving intestinal absorption and immune function, all medicaments are in a list of Chinese medicaments for both eating and medicament published by Weideng.

In the medicinal and edible herbal composition for improving intestinal absorption and immune function of the invention,

the herba Taraxaci is dried whole plant of Taraxacum mongolicum hand-held of Compositae, taraxacum sinicum Kitag of Taraxacum sinicum or same genus. Bitter, sweet and cold; it enters liver and stomach meridians. Has the effects of clearing away heat and toxic materials, relieving swelling, dispersing pathogen accumulation, inducing diuresis, and treating stranguria. The traditional Chinese medicine composition is mainly used for treating furuncle pyogenic infections, intestinal carbuncle, damp-heat jaundice, heat stranguria and pain and the like in clinic. Modern pharmacological research shows that the dandelion has wide biological activity and is mainly focused on broad-spectrum bacteriostasis, tumor resistance, gastrointestinal tract function, liver protection, cholagogue, immunity, antioxidation and the like. Studies have confirmed that the dandelion aqueous extract has a stronger inhibitory effect on the activity of Escherichia coli (E. The dandelion polyphenol has certain bacteriostatic action on staphylococcus aureus, bacillus subtilis, E.coli and salmonella, and the bacteriostatic action on the staphylococcus aureus and the bacillus subtilis is particularly obvious. Has obvious inhibition effect on gram-positive bacteria (staphylococcus aureus and bacillus subtilis).

Radish seed, the base source is the dried mature seed of radish seed of cruciferae L. Pungent, sweet and neutral in flavor; it enters lung, spleen and stomach meridians. Has effects of resolving food stagnation, relieving flatulence, descending qi and eliminating phlegm. It is mainly used for treating diseases such as diet stagnation, abdominal pain and distention, constipation, stagnation and dysentery. Raphani semen contains Leluotaxane, and has metabolic enzyme inducing effect. The sulforaphane has obvious inhibition effect on staphylococcus and coliform bacillus. The radish seed aqueous extract has the pharmacological action of relaxing the pyloric sphincter of the stomach, quickly emptying the stomach and preventing food from being accumulated in the stomach.

The base source of the hawthorn is dried mature fruit of Crataegus pinnatifida Bge.var.major N.E.Br. or Crataegus pinnatifida Bge. Sour and sweet in taste, slightly warm in nature; it enters spleen, stomach and liver meridians. Has effects of resolving food stagnation, invigorating stomach, activating qi-flowing and removing blood stasis. It is mainly used for treating diseases such as meat food retention, gastric cavity fullness, dysentery, abdominal pain, hyperlipidemia, etc. The hawthorn contains lipolytic enzyme, can enhance the action of enzyme after entering stomach, promotes the digestion of meat, is beneficial to the conversion of cholesterol, and effectively solves dyspepsia. The hawthorn can promote the secretion of enzymes in gastric juice, promote digestion and relieve abdominal distension, pantothenic acid, abdominal pain, diarrhea and other symptoms. The hawthorn is rich in pectin, and can promote gastrointestinal motility, thereby being helpful for relieving constipation symptoms.

Endothelium corneum Gigeriae Galli, the basal source is inner wall of dry sand sac of Gallus Gallus domesticus Brisson of Phasianidae. Sweet in flavor and mild in nature; it enters spleen, stomach, small intestine and bladder meridians. Has effects of invigorating stomach, resolving food stagnation, astringing essence and relieving enuresis. Is mainly used for treating indigestion, vomiting, diarrhea, infantile malnutrition and the like in clinic. The endothelium corneum Gigeriae Galli mainly contains gastric hormone, keratin, amino acids, etc., and has effects of increasing gastric secretion, improving gastrointestinal digestion, and accelerating gastric emptying rate.

Malt, the base source is mature fruit of Hordeum vulgare L. Sweet in flavor and mild in nature; it enters spleen and stomach meridians. Has the effects of promoting qi circulation, promoting digestion, invigorating spleen, stimulating appetite, and relieving lactation and flatulence. It is mainly used for treating indigestion, abdominal pain, spleen deficiency and anorexia. The malt contains isomaltose, and can regulate animal intestinal flora, raise antibody concentration and increase the number of immunocytes, so as to maintain gastrointestinal microecology and immunological function. The maltitol can reduce membrane lipid peroxidation, is a good free radical scavenger, and protects gastric mucosa.

The base source of the citrus aurantium is dry flower buds of citrus aurantium L. Bitter and sour taste, slightly cold nature; it enters liver and spleen meridians. Has effects in promoting qi circulation, relieving epigastric distention, promoting digestion, eliminating phlegm, dispersing stagnated liver qi, regulating qi-flowing, regulating stomach function, and relieving vomit. Is mainly used for treating symptoms of chest and abdomen stuffiness and distending pain, indigestion, phlegm retention, rectocele, discomfort in chest and hypochondrium, nausea and vomiting, poor appetite and the like in clinic. The seville orange flower contains polymethoxylated flavone, and has remarkable biological activity, including antivirus, antioxidation, anti-inflammatory, antitumor, antithrombotic, etc. The limonin compounds in the seville orange flower have the activities of scavenging free radicals and resisting cancers.

Poria cocos, the basic source is dried sclerotium of Poria cocos (Schw.) Wolf, a fungus of Polyporaceae. Sweet and light taste, mild in nature; it enters heart, lung, spleen and kidney meridians. Has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. It is mainly used for treating spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, etc. Poria contains pachyman, and has inhibitory effect on various bacteria. Can reduce gastric acid, and has prophylactic effect on digestive tract ulcer; has obvious protective effect on liver injury; has anti-tumor effect; can regulate the immune function in various aspects. Pachymic acid contained in Poria has effects of enhancing immunity, resisting tumor, tranquilizing mind, and lowering blood sugar.

And (3) analysis of the formula and the prescription:

dandelion-heat clearing and bowel relaxing;

radish seed, semen raphani, to promote digestion, remove distention and direct qi downward;

endothelium corneum gigeriae galli, hawthorn and malt are used for strengthening stomach, promoting digestion and promoting qi circulation;

seville orange flower-Daphne herb-Daphne Giraldii Nitsche for promoting digestion, promoting qi circulation, regulating qi and harmonizing stomach.

The medicinal and edible herbal composition takes the dandelion and the radish seed as the monarch drugs, and clears away heat in the stomach and intestine; the chicken's gizzard-membrane, the hawthorn and the malt are used as ministerial drugs, the stomach is invigorated to supplement and transform the source, and the qi is promoted to eliminate food stagnation; the seville orange flower can act as the qi of the whole body, and has the effects of dispelling stagnation, promoting digestion, strengthening spleen and descending qi.

The medicine and food homologous herbal composition is applicable to the symptoms of poor defecation habit caused by poor intestinal absorption, dyspepsia, abdominal distension and pain and the like caused by low immune function.

The intestinal tract is the largest digestive organ and toxin expelling organ of a human body and comprises five parts, namely small intestine, large intestine, anus, intestinal juice and intestinal flora. The intestinal tract has an absorption function, the small intestine is a nutrient absorber, and the large intestine has an absorption function on water liquid in food residues. The functional disorder of water absorption affects the peristalsis of intestines and stomach, and when the peristalsis of the intestines is weakened, food residues stay in the intestines for a long time, the water absorption is increased, and feces are dry, so that difficult or uncomfortable defecation can be caused. When people see sub-health rather than diseases, the defecation is difficult or uncomfortable, and the people often have a delay and form chronic habitual constipation, which is not good in defecation habit in the long run. Pharmacological experiment research results show that after the medicinal and edible herbal composition is used for treatment, the rat intestinal tissue structure is clear, and epithelial cells are arranged in order. The intestinal epithelium is the part which can absorb nutrient and liquid to the maximum extent in the body, and the maintenance of the epithelial cells by the medicinal and edible herbal composition shows that the composition can effectively improve the absorption function of the intestinal tract. The feedback of pharmacological experiments shows that the constipation and other symptoms of children and adults can be effectively improved by taking the medicinal and edible herbal composition.

The intestinal tract is not only the main site for the digestion and absorption of nutrients, but also the congenital barrier for ensuring the homeostasis of the body. The important link forming the intestinal immunity is the immune barrier, the intestinal tract is the largest immune organ in vivo, the immunity of the intestinal tract is dragged to move the whole body, and the abnormal occurrence of the low immune function of the intestinal tract can cause the digestion and absorption function disorder of nutrient substances, dyspepsia, abdominal distension and pain, the enhancement of the susceptibility to pathogenic microorganisms and the like, thereby causing various diseases. Pharmacological experiment research results show that the normal group (N groups) has clear intestinal tissue structure and orderly arranged goblet cells; the intestinal tissue structure of the model group (group M) collapsed and goblet cells increased compared to the normal group; compared with the model group, the intestinal tissue of the medicinal and edible herbal composition group (KLB group) has compact structure and less goblet cell number. Goblet cell mucus secreting cells, which are closely related to glucose and amino acid uptake, are part of the mucosal barrier of the gut. The maintenance of the medicinal and edible herbal composition on goblet cells and epithelial cells proves that the medicinal and edible herbal composition can effectively improve the immune function of intestinal tracts. Feedback of pharmacological experiments prompts that children and adults taking the medicinal and edible herbal composition can effectively improve symptoms such as dyspepsia, abdominal distension and pain.

The solid beverage prepared from the medicinal and edible herbal composition has good feedback on practical application, and takes an applicable questionnaire in Beijing area as an example. We find that the symptoms of constipation, fullness after eating and the like are improved after people who have poor dietary habits drink the traditional Chinese medicine granules prepared from the medicinal and edible herbal composition. The symptoms of diarrhea, oral ulcer, halitosis and the like are obviously reduced or eliminated after a person who experiences oily or spicy food takes the traditional Chinese medicine granules prepared from the medicinal and edible herbal composition to drink. The experients with fatness and poor self-induction intestinal peristalsis have regular stool, normal appetite and weight reduction tendency after taking the traditional Chinese medicine granules prepared from the medicinal and edible herbal composition.

The above medicinal materials are common foods, and have no toxicity and high safety. The medicinal and edible herbal composition has the effects of regulating intestinal flora, improving intestinal function and maintaining intestinal health. The medicinal and edible herbal composition has good regulating effect on gastrointestinal heat accumulation, poor eating habits and low immunity of children and children, has no heavy bitter taste, has sufficient natural fragrance of the herbal, and can be taken by children and children. Meanwhile, the medicinal and edible herbal composition is also suitable for people with healthy intestinal tracts, has comfortable mouthfeel, and can be developed into natural herbal beverages, foods and the like.

The intestinal functions of infants and children are not completely developed, the digestive ability is weak, and in addition, the infants and children are rich in life and have fun and delightful activities, and the children often eat a large amount of hamburgers, fried chicken, chocolate, rice crust and other snacks which are easy to cause gastrointestinal heat accumulation, so that a large number of infants and children have gastrointestinal heat accumulation symptoms, such as constipation, poor defecation habits, dyspepsia, abdominal distension and pain, halitosis, red tongue, uneasy sleep, easy cold and the like. Eating snacks breaks up normal three meals a day, frost is added on snow to gastrointestinal development, and vicious circle is involved. If parents do not select milk powder for infants, gastrointestinal heat accumulation of babies is also easily caused. Adverse environments such as air pollution also affect the gastrointestinal development of this generation of infants and children. The medicinal and edible herbal composition can treat and improve gastrointestinal heat accumulation symptoms, enhance intestinal functions of infants and children, assist intestinal development and improve autoimmunity of infants and children.

The composition can be made into decoction, extract, powder, chinese medicinal granule, decoction, pill, powder, unguent, pellet, tablet, lozenge, colloid, yeast, dripping pill, soft capsule, superfine powder, colloid, injection, etc. The most common decoction is prepared by cleaning the traditional Chinese medicines, soaking for one hour, adding water for decocting, boiling over strong fire, decocting over slow fire for half an hour, and pouring out the filter residue. One dose is taken in the morning and at night. The composition is also suitable for infants. 1/6 of adult for newborn, 1/3-1/2 of adult for infant, 2/3 of adult for infant and toddler, and adult for school-age children.

Has the advantages that:

(1) The health-care food can achieve the effect of maintaining the health of the intestinal tract by adjusting the intestinal flora and improving the intestinal function, has the advantage of 'preventing the disease first', and maintains the health of the intestinal tract so as to improve the immunity of a human body.

(2) The pharmacological experiment result shows that: the maintenance of the medicinal and edible herbal composition on goblet cells and epithelial cells shows that the medicinal and edible herbal composition can effectively improve the absorption function and the immune function of intestinal tracts.

Drawings

FIG. 1 is a colon histopathology map of SD rats in each group. ( Note: HE staining, 20 x under the mirror, scale =50 μm. A: normal group (N); b, model group (M group); c, medicinal and edible herbal composition group (KLB group). )

Detailed Description

The present application will be further described with reference to the drawings and detailed description so that those skilled in the art can more easily understand the present application, but the present invention is not limited thereto.

Laboratory instruments, reagents and materials used in the examples of the present invention are commercially available.

Example 1

A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight:

10 parts of dandelion, 10 parts of hawthorn, 10 parts of endothelium corneum gigeriae galli, 10 parts of malt, 10 parts of radish seed, 6 parts of seville orange flower and 10 parts of poria cocos.

Example 2

3 parts of dandelion, 3 parts of hawthorn, 3 parts of endothelium corneum gigeriae galli, 3 parts of malt, 3 parts of radish seed, 2 parts of seville orange flower and 3 parts of poria cocos.

Example 3

6 parts of dandelion, 6 parts of hawthorn, 6 parts of endothelium corneum gigeriae galli, 6 parts of malt, 6 parts of radish seed, 4 parts of seville orange flower and 6 parts of poria cocos.

Example 4

A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 9 parts of dandelion, 9 parts of hawthorn, 9 parts of endothelium corneum gigeriae galli, 9 parts of malt, 9 parts of radish seed, 6 parts of seville orange flower, 9 parts of poria cocos and 9 parts of momordica grosvenori.

Example 5

A medicinal and edible herbal composition for improving intestinal absorption and immune function is prepared from the following raw material medicines in parts by weight: 5 parts of dandelion, 5 parts of hawthorn, 5 parts of endothelium corneum gigeriae galli, 5 parts of malt, 5 parts of radish seed, 3 parts of seville orange flower and 5 parts of poria cocos.

Example 6

10g of dandelion, 10g of hawthorn, 10g of endothelium corneum gigeriae galli, 10g of malt, 10g of radish seed, 6g of seville orange flower and 10g of poria cocos.

This is 1 dose.

The preparation method comprises the following steps: taking the traditional Chinese medicine formula granules according to the weight ratio to obtain the traditional Chinese medicine.

Example 7

This is 1 dose.

The preparation method comprises the following steps: cleaning the above Chinese medicinal materials, soaking for one hour, decocting with water, boiling with strong fire, decocting with slow fire for half an hour, and removing residue. One dose is taken in the morning and at night.

Example 8

5g of dandelion, 5g of hawthorn, 5g of endothelium corneum gigeriae galli, 5g of malt, 5g of radish seed, 3g of seville orange flower and 5g of poria cocos.

This is 1 dose.

Experimental example 1 pharmacological experiment of medicinal and edible herbal composition for improving intestinal absorption and immune function

SPF grade SD rats 30, male, 15-day-old, 40 ± 10g in weight, purchased from sbeff (beijing) biotechnology limited, license No.: SCXK (Beijing) 2016-0002. The feed is raised in an animal house of the college of traditional Chinese medicine of Beijing university of traditional Chinese medicine, the environment is shielded, the temperature is 22-25 ℃, the humidity is 50-60%, the feed water freely enters, and the natural illumination is carried out. The animal protocol was previously approved by the animal research committee of the university of traditional Chinese medicine, beijing.

Normal group (N group) normal diet. The model group is fed with special high-heat feed and red star milk powder solution which are uniformly purchased, produced and controlled by the Schbefu (Beijing) biotechnology limited company for 6 days to form a gastrointestinal heat accumulation model. The medicinal and edible herbal composition group (KLB group) is used for intragastric gavage of the medicinal and edible herbal composition granular aqueous solution on the basis of molding.

Milk solution: dissolving red star whole sweet milk powder in pure water to prepare 52% milk solution, wherein the stomach filling amount is 1mL/100g each time, and the milk solution is taken once a day.

Medicinal and edible herbal composition particle aqueous solution: the medicine and food homologous herbal composition granules which are equivalent to 10 grams of clinical decoction pieces of dandelion, 10 grams of raw hawthorn, 10 grams of vinegar chicken's gizzard-membrane, 10 grams of malt, 10 grams of fried radish seed, 10 grams of poria cocos and 6 grams of daidai flower are purchased from Beijing Kangrentang pharmaceutical industry Limited company, and the product is an additive-free ' full ingredient ' traditional Chinese medicine formula granule. The Chinese medicinal granule is dissolved in pure water to obtain solution with concentration of 1.32g/ml twice a day.

Water was withheld on day 6 at night, blood was taken from the abdominal aorta after anesthesia on day 7 morning and colon tissue was collected and fixed in 10% formalin for at least 24h for further histopathological assessment, specifically 3cm above the cecum end. Rat intestinal tissue was fixed with sufficient 10% formalin for 24h, and tissue sections were prepared by material extraction, dehydration, wax immersion, embedding, sectioning, HE staining, and the like.

Experimental study results show that the normal group (N group) has clear intestinal tissue structure, and goblet cells and epithelial cells are arranged in order; the intestinal tissue structure of the model group (group M) collapsed and goblet cells increased compared to the normal group; compared with the model group, the intestine tissue of the medicinal and edible herbal composition group (KLB group) has compact structure and less goblet cell number, and the structure is shown in figure 1. Goblet cell mucus secreting cells, which are closely related to glucose and amino acid uptake, are part of the mucosal barrier of the gut. The intestinal epithelium is the site of maximum nutrient and fluid absorption within the body and must provide a tight barrier to prevent the invasion of pathogens. The maintenance of the medicinal and edible herbal composition on goblet cells and epithelial cells shows that the medicinal and edible herbal composition can effectively improve the absorption function and the immune function of intestinal tracts.

Claims

1. An oral preparation for treating heat accumulation syndrome of stomach and intestine is characterized by being prepared from the following raw material medicines in parts by weight:

10 parts of dandelion, 10 parts of hawthorn, 10 parts of endothelium corneum gigeriae galli, 10 parts of malt, 10 parts of radish seed, 6 parts of seville orange flower, 10 parts of poria cocos and 10 parts of momordica grosvenori.

2. The oral formulation of claim 1, wherein the oral formulation is a granule.

3. Use of the oral formulation of claim 1 for the manufacture of a medicament for the treatment of gastrointestinal heat accumulation.