CN101589811A - A kind of nutraceutical and preparation method thereof with promotion digestive function - Google Patents
A kind of nutraceutical and preparation method thereof with promotion digestive function Download PDFInfo
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Abstract
The present invention relates to a kind of nutraceutical and preparation method thereof, belong to field of functional food with promotion digestive function.Nutraceutical of the present invention is mainly made by following medicine and food raw materials in portion by weight: six bent 1-5 parts, Chinese yam 1-5 part, the membrane of a chicken's gizzard 1-5 part, Fructus Hordei Germinatus 1-5 part, hawthorn 1-5 part, banksia rose 1-5 part, radish seed 1-5 part, brush-cherry seed 1-5 part, fructus cannabis 1-5 part, Poria cocos 1-5 part.Show that through the zoopery result nutraceutical of the present invention has the effect of tangible promotion digestive function, be applicable to the crowd who needs to promote digestion, but be not suitable for children.
Description
Technical field
The present invention relates to a kind of nutraceutical and preparation method thereof, belong to field of functional food with promotion digestive function.
Background technology
The digestion of food is divided into the digestion in intraoral digestion and the stomach, and people's digestion is from the oral cavity.Three pairs of salivary gland are arranged: rib gland, lower jaw gland, sublingual gland in the oral cavity.Contain ptyalin, lysozyme, glutinous albumen and globulin etc. in the saliva.The people secretes 1000～1500mL saliva every day.Food is chewed and mixed formation food group with saliva the star enters stomach through swallowing.Ptyalin can resolve into maltose with starch.Digestion in the stomach, the motion of stomach has receptive relaxation, tonic contraction and wriggling.The wriggling of stomach is further pulverized food and fully is mixed into chyme with gastric juice.It is water white strong acidic liquid that the gland cell of stomach lining secretes gastric juice, PH1.5～2.0.Gastric juice comprises hydrochloric acid, glutinous albumen, pepsin and gastric lipase etc.The form secretion of propepsin is activated under strong acid condition.It is relatively poor to the selectivity of peptide bond hydrolysis, can be hydrolyzed into peptone to various water soluble proteins.Gastric lipase is diglyceride and fatty ester (FA) with triglyceride hydrolysis under sour environment.But the strong acidic environment in the stomach is not the optimal pH of gastric lipase effect.Fat tentatively is emulsified into 0.5～1.9um in stomach little fat drips.Mucus plays lubricated and barrier action at mucous membrane surface.Hydrochloric acid provides sour environment for pepsin, and can suppress bacterial reproduction.Hydrochloric acid enters small intestine can promote pancreatic juice, intestinal juice and choleresis.Sour environment also helps the absorption of small intestine to calcium, iron.The secretion of gastric juice is an initiatively power consumption process.Gland cell obtains raw material from blood plasma, and the secretion that they are synthetic is stored in the gland cell or from wherein discharging.Promote the adjusting of gastric secretion to import maincenter through V, VII, IX, X into to cranial nerve, reach the gastric gland body cell and cause gastric secretion through being confused absent-minded nerve again by chewing and swallow The food stimulation.Vagus nerve also can make the G cell in the mucous membrane of pylorus position discharge gastrin, promotes gastric secretion by blood circulation.Food causes a large amount of gastric secretions (being called the gastric phase secretion) after going into stomach.The existing nerve regulation of adjusting of gastric phase secretion also has body fluid to regulate.When chyme entered duodenum, the material that also has a kind of similar gastrin promoted gastric secretion.In addition, the metabolin of the hydrochloric acid of high concentration, hypertonic solution and fat has the effect that suppresses gastric secretion.Acidity reaches pH1.2～1.5 and o'clock can suppress the release of gastrin in the stomach, thereby suppresses gastric secretion.Fat causes that CCK discharges, and suppresses the emptying of stomach.The absorption of enteron aisle, the digestion product of food, power and water Xie Zhi etc., the process that enters blood and lymph by the intestinal mucosa epithelial cell is called as absorption.The cell membrane of mucosal epithelium cell is double-deck fat molecular film, and liposoluble substance easily passes through cell membrane.Water-soluble substances then can pass through cell membrane under the help of protein carrier.The direction of material by cell membrane has simple diffusion, solvent towing, alienation diffusion, active rotation, ion-exchange diffusion and goes into born of the same parents and go out born of the same parents etc.Simple diffusion is the diffusion along concentration gradient and ion-conductance field force direction, not consumed energy.The solvent towing is that small-molecule substance is by the process of current drag.The factor that influences the material towing has solute size, osmotic pressure gradient, hydrostatic pressure gradient and electric field force.The alienation diffusion is the diffusion of the suitable concentration gradient of the protein carrier mediation on the cell membrane; It is not need catabiotic passive transportation.Active transport is by the carrier consumed energy, the transhipment of contrary concentration gradient and electrochemical gradient; The exchange diffusion is two kinds of processes of suitable, the contrary electrochemical gradient back exchange transhipment of ion of pairing mutually.Various nutriment majorities are digested and are absorbed at small intestine.The absorption of glucose by intestinal mucosa be one special, with the active process of sodium coupling.Na
+-carrier-glucose compound Na
+Concentration gradient enters cell, and the inside and outside concentration gradient of cellular sodium mainly relies on Ma
+/ K
+Pump is kept, so the transhipment of glucose is the process of a power consumption.The absorption of amino acid and little peptide is equally by carrier mediated.Amino acid carrier mostly is Na
+Dependence, the carrier of little peptide then depends on H
+Little peptide is absorbed the back by enterocyte and is hydrolyzed into amino acid rapidly by the peptase in the endochylema.The digestion product of lipid forms mixed micelle under the effect of cholate, mixed micelle reaches enteric epithelium by the unstirredlayer between intestinal mucosa and enteric cavity.FA and glyceride fat digestion products such as (MG) is dissolved in the lipid bilayer of cell membrane.Someone finds that FA is transported to entoplasm net with FA from brush border in conjunction with albumen.The aliphatic acid of long-chain is activated the back by enzyme and combines with acetyl coenzyme A and then form glycerine three and waste.Chylomicron is formed in participation at phosphatide, cholesterol, apolipoprotein.Chylomicron enters the space between cells, enters blood through lymphatic vessel.The chyme of being digested and assimilated by small intestine enters large intestine under the control of ileocaecal sphineter.The main effect of big intestinal juice is protection intestinal mucosa and lubricated ight soil.The major function of large intestine is to store swill and further absorb moisture.Per day for adults is taken in 1500～2500mL water, enters large intestine with digestive juice, and is absorbed at colon.Water in the ight soil only has 150mL usually.The main mode that small intestine absorbs moisture is infiltration.The electrolyte of small intestine is Na especially
+The osmotic pressure that produces can promote the absorption to water.
According to the digestion principle of human body food, Chinese and Western medicine has many medicines that help digestion to emerge at all times, and certain promotion digestion effect is all arranged, and still, effect is still not fully up to expectations.Folk prescription commonly used, the herbal mixture effect neither be clearly.Such as: when six songs are used in digestants traditional Chinese medical science requirement at all times, need to add and make ball, diffusing swallowing in the compound.But at present clinical all putting into eaten soup after compound decocts, and this can affect the treatment.This may be the not strong reasons of the six bent efficacy of a drug.Therefore, nutraceutical research and development safety, that have tangible promotion digestion can benefit the consumer that more than one hundred million needs promote the digestion nutraceutical.
Summary of the invention
The present invention is directed to the defective in the above-mentioned field, a kind of nutraceutical of more efficiently promotion digestive function is provided, this prescription meets the theory of integration of drinking and medicinal herbs fully, is a kind of natural green nutraceutical.
Purpose of the present invention just provides a kind of digestive function of promotion nutraceutical that has.
Another object of the present invention has provided a kind of nutrient food preparation that promotes digestive function that has.
A kind of nutraceutical with promotion digestive function is mainly made by following medicine and food raw materials in portion by weight: six bent 1-5 parts, Chinese yam 1-5 part, the membrane of a chicken's gizzard 1-5 part, Fructus Hordei Germinatus 1-5 part, hawthorn 1-5 part, banksia rose 1-5 part, radish seed 1-5 part, brush-cherry seed 1-5 part, fructus cannabis 1-5 part, Poria cocos 1-5 part.
Described nutraceutical, the weight portion of its preferred medicine and food raw materials is: six 2 parts of songs, 2 parts of Chinese yams, 1 part of the membrane of a chicken's gizzard, 1 part in Fructus Hordei Germinatus, 2 parts of hawthorn, 1 part of the banksia rose, 1 part of radish seed, 1 part of brush-cherry seed, 1 part of fructus cannabis, 1 part in Poria cocos.
The weight of its preferred medicine and food raw materials respectively is: six bent 2000g, Chinese yam 2000g, the membrane of a chicken's gizzard 1000g, Fructus Hordei Germinatus 1000g, hawthorn 2000g, banksia rose 1000g, radish seed 1000g, brush-cherry seed 1000g, fructus cannabis 1000g, Poria cocos 1000g.
The preparation method of described nutraceutical:
(1) take by weighing the banksia rose, radish seed, brush-cherry seed, fructus cannabis, Poria cocos etc. 5 flavor medicine and food raw materials in proportion, extract and use 70% alcohol extract, refluxed 3 hours, extract secondary, merging extract vacuum concentrated dry extract 1;
(2) take by weighing Chinese yam, the membrane of a chicken's gizzard etc. 2 flavor medicine and food raw materials in proportion, use 90% alcohol extract, refluxed 3 hours, the extraction secondary, with the extract vacuum concentrated dry extract 2;
(3) take by weighing six songs, Fructus Hordei Germinatus, hawthorn etc. 3 flavor medicine and food raw materials in proportion, extract, refluxed 3 hours, extract secondary with distilled water, with the extract vacuum concentrated dry extract 3;
Merge dry extract 1,2,3, it is ground into 200 order powder, be active component of the present invention.Press the method for production of soft capsule, be filled into capsule shells.
To reclaim ethanol and concentrated during with alcohol extract, concentrate and adopt vacuum to concentrate.Vacuum concentrates and claims decompression to concentrate again, and vacuum concentrates has lot of advantages.Not only can save a large amount of energy.Simultaneously,, avoided the destruction and the loss of thermally labile component, preserved the nutritional labeling and the fragrance of raw material better because material is not subjected to temperatures involved.
The dry extract that obtains after described the concentrating also need is following dry 3 hours at 50-60 ℃.
Described nutraceutical, its formulation are soft capsule.
Theory of traditional Chinese medical science thinks that digestants and purgatives medicine are the Chinese medicine of digest food and logical stool.The site of action of digestants though there is not the defaecation effect, can make food promote at stomach downwards, helps digestion, absorbs and drains.Draining on this point, similarity is arranged with purgatives medicine.And in traditional ancient prescription of some promoting digestions, this two classes medicine also usually uses during compatibility mutually, as zhishi daozhi pills etc.Digestants can both use the real example asthenic symptoms.The site of action of purgatives medicine is at intestines, and purgatives medicine only is used for real example, is not used in asthenic symptoms.Digestants claims Chinese digestant drugs for removing food accumulation and stomach digestants, the i.e. meaning of promoting digestion again.Digestants can be regulated gastrointestinal function, helps digest, with treatment having indigestion and indigestion.Stagnant under one's belt, use during indigestion, to help digest.According to this theory of traditional Chinese medical science, we are by to the chemical composition of medicine and food raw materials and studies show that of pharmacologically active such as six songs, Chinese yam, the membrane of a chicken's gizzard, Fructus Hordei Germinatus, hawthorn, the banksia rose, radish seed, brush-cherry seed, fructus cannabis, Poria cocos:
Six songs
Six songs are after medicines such as polygonum flaccidum, sweet wormwood, almond, Siberian cocklebur grass, rde bean last adding flour or wheat bran mix, through the herbal leaven that fermentation forms, to have another name called Medicated Leaven, Divine Comedy.Bent derivation product is still built song, is made up of 50 kinds of traditional Chinese medicines; Adopt the song that rues, form by 30 kinds of traditional Chinese medicines.Nature and flavor and effect flavor are sweet, hot, warm in nature.Effect and stomach help digestion.Cure mainly eating accumulation, the vexed abdominal distension of gastral cavity, appetite is not fragrant, illness such as have loose bowels.This medicine is usually used in following traditional prescription: 1. bent art ball (" formulary of peaceful benevolent dispensary "): six songs, rhizoma atractylodis, and the treatment injury due to diet, brain diaphragm ruffian is vexed; 2. pill for promoting digestion (" formulary of peaceful benevolent dispensary "): six songs, wheat tiller, dark plum, rhizoma zingiberis, treatment splenogastric asthenia, digesting and absorbing the essence of foodstuff not, abdominal distension uncomfortable in chest; 3. bent tiller Aurantii Immaturi and Atractylodis Pill (" medical science main story "): six songs, Fructus Hordei Germinatus, the dried immature fruit of citron orange, the bighead atractylodes rhizome, lotus leaf are boarded and are ball, and treatment internal injury diet is had loose bowels.In famous prescription Pachyma Compound Digestive Tonic Pill, six songs also are main medicines.Main component, six songs mainly contain saccharomycete.Its composition has amylase, egg from enzyme, lipase, volatile oil, glycoside, fat oil, vitamin B complex etc.Pharmacological action, six songs have the effect that increases digestive juice secretion, and contained enzyme can strengthen the digestion to food.Clinical practice, treatment acute or chronic gastritis, enteritis, stomach do not relax, poor appetite.Not fragrant, the food of not pursuing progress of appetite after treatment flu back or the chemotherapy.Treatment old man and baby anorexia.Treatment is taken the stomach that Chinese herbal medicine causes and is not relaxed, and influences appetite.Using method: be decocted in water for oral dose, go into ball, loose and swallow.Clinical experience strengthens digestive function, and six songs are traditional digestant, contain multiple digestive ferment, as amylase, protease, lipase, the effect that strengthens digestive function is arranged.Big after being ill, behind the operation back, chemotherapy and when taking Chinese herbal medicine, normal six songs that add help digest to assist recovering appetite in Chinese medicine compound prescription.For old man and children anorexia, six songs also are the Chinese medicine of using always.Six bent digestive active ingredients are multiple digestive ferments, but digestive ferment can be destroyed when high temperature decocts, so ancient prescription is all with making ball, diffusing swallowing, the few decoction in the compound six bent addings.7 of Compendium of Material Medica six bent attached sides all are that ball looses, and not having a side is decoction.But at present clinical all putting into eaten soup after compound decocts, and can affect the treatment.This may be exactly the not strong reasons of the six bent efficacy of a drug.Six is bent nontoxic.In routine dose, be decocted in water for oral dose or make the compound pill and do not have uncomfortable reaction.Take for a long time or heavy dose is decocted in water for oral dose and does not also have obvious adverse reaction.
Chinese yam
Chinese yam is the qi-restoratives key medicine, is rich in Dioscin, tens amino acid, and difficult in vivo protein and the carbohydrate that is hydrolyzed to needed by human body is with strengthening body.Amylase in the Chinese yam can move in the stimulating gastrointestinal road, short gastrointestinal contents emptying, and the utilization rate of raising protein improves digestion power, improves the absorption of human body to calcium, the acceleration bone growth.The patient who is usually used in deficiency of the spleen causing weakness of QI, anorexia and loose stool clinically and has loose bowels, both enriching spleen-QI was stolen the spleen sun again.Clothes of a specified duration " tonifying middle-Jiao and Qi power, longue meat " (" refreshing family book on Chinese herbal medicine warp ").Chinese yam is the tonifying middle-Jiao and Qi medicine.The clinical weakness of the spleen and stomach that is used for the treatment of, the stomach myoelectricity shows: Chinese yam can reduce the rat stomach electricity slow wave width of cloth, can obviously resist the caused slow wave wave amplitude of rheum officinale simultaneously and raise.Further research also shows, the obviously tetanic property of the isolated rat ileum contraction that causes of antagonism acecoline and barium chloride of Chinese yam but can not resist the stripped duodenum that adrenalin hydrochloride causes or the inhibitory action of ileum.The prompting Chinese yam has the intestinal tube smooth muscle spasm of alleviation and resists neurohumoral effect, can also strengthen the small intestine absorption function, suppresses the secretion of serum amylase, but choleresis and gastric secretion are not all had obvious influence.Intestines and stomach are digestion, the organ that absorbs nutriment.Digestion process mainly rely on GI motion and digestive ferment be used for finish.Can regulating action be arranged to the secretion and the physiologically active thereof of GI motion or some digestive ferment, it just has the effect that promotes digestion so.
The membrane of a chicken's gizzard
The membrane of a chicken's gizzard gizzard mainly contains keratin and compositions such as bile prime, gastric hormone.The membrane of a chicken's gizzard gizzard contains keratin.The gizzard keratin membrane contains a kind of glycoprotein, and the content of its cysteine is lower than general epithelial tissue.The ceroid of gizzard and uranidin, its composition are bilitrien and biliverdin.Gizzard contains Cobastab
1, B
2, niacin, vitamin C etc.The membrane of a chicken's gizzard also contains gastric hormone, several amino acids, trace element, micro-pepsin, ammonium chloride etc.The membrane of a chicken's gizzard flavor is sweet, and property is flat.Effect: it is long-pending to help digestion, and ends losing and lets out.Cure mainly distant stomach weakness, accumulation of food in the stomach and intes tine due to indigestion, abdominal fullness and distention, illnesss such as enuresis seminal emission.This medicine is usually used in following traditional prescription: 1. beneficial spleen cake (" Records of Tradition Chinese and Western Medicine in Combination "): the bighead atractylodes rhizome, Grilled chicken gold, rhizoma zingiberis, jujube meat, and the treatment diet reduces, long having loose bowels; 2. proved recipe (Compendium of Material Medica) medical center collection is wanted: chicken yellow skin five money, make clothes, and the drip of treatment urine, unbearably painful.Pharmacological action mainly is to strengthen digestion, and gastric secretion, acidity and eupepsy all have enhancing behind the human oral the membrane of a chicken's gizzard.The stomach motor function strengthens, and gastric emptying is obviously accelerated.The membrane of a chicken's gizzard itself does not contain digestive ferment, and it is that gastric hormone causes that its effect that promotes gastric secretion and motion enters in the blood after owing to drug absorption.Behind the mouse stomach 30 minutes, its effect that increases gastric secretion was not obvious, after 60 minutes tangible effect is arranged.The digestion that the membrane of a chicken's gizzard is described is slower, but relatively more lasting.Clinical practice, poor appetite and indigestion that treatment chronic gastritis and various diseases cause.Digestive function goes down the food of not pursuing progress after the treatment chemotherapy.Clinical experience treatment indigestion, helping digest is symptomatic treatment.Paddy Fructus Hordei Germinatus and six songs mainly are the effects of digestive ferment, and effect is at once arranged behind the clothes.The membrane of a chicken's gizzard is to increase gastric secretion and accelerate emptying, is the effect of gastric hormone, just plays effect in back one hour taking medicine.These medicines have a time difference, for synergy, and should be with using.Clinical observation, the membrane of a chicken's gizzard is nontoxic.In routine dose and heavy dose, be decocted in water for oral dose and do not have uncomfortable reaction.Take for a long time and also do not have bad reaction.
Fructus Hordei Germinatus
Compositions such as the main starch-containing digestive ferment of Fructus Hordei Germinatus.The starch-containing digestive ferment of digestive enzymes Fructus Hordei Germinatus, conversion carbohydrase.Other nutritional labeling Fructus Hordei Germinatus also contain Cobastab, fat, phosphatide, dextrin, maltose, grape wine sugar, hordenine etc.Malty is sweet, and property is flat.Effect: and stomach helps digestion delaactation.Cure mainly accumulation of food in the stomach and intes tine due to indigestion, gastral cavilty is glutted, and is weakness of the spleen and the stomach, and appetite is not fragrant, and ablactation and milk smoulder and illnesss such as breast stomachache.This medicine is usually used in following traditional prescription: 1. Pachyma Compound Digestive Tonic Pill (" danxi's experiential therapy "): coloured malt, hawthorn, six songs, radish seed, the tuber of pinellia, dried orange peel, the capsule of weeping forsythia, Poria cocos, and the corruption of treatment dyspepsia, ruffian is had one's mind filled with bloated; 2. proved recipe (" danxi's experiential therapy "): fry the wheat tiller, grind, gulp down, treatment milk in postpartum can not reach mammary swelling.Pharmacological action mainly is that the effect Fructus Hordei Germinatus that strengthens digestion contains digestive ferment and Cobastab, and the effect that strengthens digestion is arranged.Other effects also have hypoglycemic and hepatoprotective effect, prevent and treat hypercalcinuria and oxidation resistant effect in addition.Clinical practice treatment indigestion and poor appetite.Clinical experience, the treatment indigestion, paddy Fructus Hordei Germinatus is owing to all contain digestive ferment and vitamin B complex with the treatment indigestion, has the effect that strengthens digestion.But enzyme can be damaged when high temperature decocts, and its effect is affected.The processing of rice sprout, Fructus Hordei Germinatus traditional Chinese medical science tradition all is to fry fragrant the use, fries fragrant and stir-bake to brown not, fry perfume (or spice) and do not lose enzyme, and stir-bake to brown can make enzyme content reduce.Fructus Hordei Germinatus is nontoxic.In routine dose, be decocted in water for oral dose and do not have uncomfortable reaction.Take for a long time or heavy dose is decocted in water for oral dose and does not also have bad reaction.
Hawthorn
Fruit for rosaceous plant hawthorn Crataegus pinnatifida Bge. or fructus crataegi cuneatae.Also haw (" 101 choosing side ") in the famous mountain.Flavor acid, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Function: long-pending, diffusing extravasated blood, expelling tenia help digestion.Cure mainly: meat Ji, Disorder lump in the abdomen, phlegm and retained fluid, ruffian are full, acid regurgitation, rush down dysentery, intestines wind, pain in the back, hernia, generation postpartum abdominal pain, lochiorrhagia, children's's breast food and stagnate.Main component is organic acid and flavone compound.Organic acid mainly contains crataegolic acid, citric acid, chlorogenic acid, ursolic acid, malic acid, oxalic acid, oleanolic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, leukotrienes, butanedioic acid, fumaric acid etc.Flavonoids mainly contains Quercetin, Vitex negundo var cannabifolia element, different Vitex negundo var cannabifolia element, cratenacin and takes off acetyl cratenacin, cosmosiin, glucose cyanidenon, Kaempferol and derivative thereof, wuzishan short, bristly hair or beard glycosides, pelargonidin, Hyperoside, epicatechin, rutin etc.In addition, still contain lactone, glycoside, lipase, protein, carbohydrate, starch, vitamin C, tannin and trace copper, sodium, zinc, iron, phosphorus, calcium etc.
The banksia rose
This product is the dry root of feverfew radix jurineae Aucklandia lappa Decne. or gray wool radix jurineae.Excavate autumn, removes the jelly on fibrous root, silt and the root head, drying.Originate in ground such as India, Palestine, also produce in Yunnan Province of China, Sichuan, Tibet, Guangdong, Guangxi in recent years, be the cultivation product, with Yunnan Lijing and enlightening celebrating output maximum.Compendium of Material Medica carries that " banksia rose, careless class also.Real name honey is fragrant, because of its fragrance such as honey also." banksia rose mildly bitter flavor.Hot, bitter, temperature.Return spleen, stomach, large intestine, gallbladder channel.Promoting qi circulation and relieving pain, warming middle-JIAO for easing the stomach.Pharmacological action, the banksia rose has spasmolysis to bronchial smooth muscle and intestinal smooth muscle, also has step-down, bacteriostasis.Clinical practice, treatment acute and chronic gastritis intestinal inflammatory abdominal pain and distension and enteritis and dysentery stomachache.Treatment peptic ulcer stomach Feng, stomach does not relax and poor appetite.The banksia rose is the most frequently used medicine of regulating qi-flowing for relieving pain.Based on taste, the pain of complete each internal organs of digestive system all can be used.Contained volatile oil, lactone and the alkaloid of the banksia rose has the effect of stronger diastole smooth muscle spasm, especially better to the effect of digestive system pain, to the spasmic pain of oesophagus, orifice of the stomach, stomach, duodenum, enteron aisle, bile duct, common hepatic duct, ductus pancreaticus and the flatulence of dysfunction, result of treatment is all arranged, and be main Chinese medicine, no matter differential diagnosis in tcm real example, asthenic symptoms can both be used.The banksia rose is a conventional Chinese medicine, and the beginning is stated from Shennong's Herbal.Modern study shows that its root contains volatile oil, and main component is a constuslactone in the oil, Saussurea Lactone, and composition such as α-costic acid, α-costol.Still contain saussurine, amino acid, sterol, synanthrin etc. in addition.Tool spasmolysis, step-down and antibacterial action.Can treat that abdomen side of body turgor, stool are unfavorable, the deposition aqueous vapor, in completely can not food, vexed, the diarrhea purulence blood of vertigo, stomach weakness, unbalanced cold and heat, the polydipsia of having loose bowels, rice indigested food, chest diaphragm ruffian, tenesmus, cold hernia etc., also can be used for treating diseases such as bronchial astehma.The prescription that with the banksia rose is the main ingredient prescription is a lot, and as banksia rose ball, aplotaxis carminative pill, Muxiang Binlang Wan, Xianglian Wan, Xiangsha Liujunzi decoction etc., it is evident in efficacy, is subjected to patient's welcome deeply.
Radish seed
Mature seed for crucifer radish Raphanus sativus L..Also the name SEMEN RAPHANI (" Japan hanako materia medica ").Flavor is hot, sweet, and property is flat.Attach to the lung and stomach meridians.Function: therapeutic method to keep the adverse qi flowing downward Dingchuan, eliminate indigestion and phlegm.Cure mainly: heavy behind cough asthma due to excessive phlegm, stagnation of QI due to dyspepsia, stagnation of QI due to dyspepsia, abdominal distension uncomfortable in chest, the diarrhea.The fatty oil of main component, volatile oil.Methyl mercaptan (methyl mercaptan) etc. is arranged in the volatile oil; Fat oil contains volume erucic acid (erucic acid), linoleic acid, leukotrienes, glycerol sinapate (glycerol sinapate).Still contain raphanin (raphanin).Separate cupreol (β-sitosterol).The radish seed flavor is hot, sweet, warm in nature.Effect: the therapeutic method to keep the adverse qi flowing downward of eliminating the phlegm, promoting digestion and removing indigestion.Cure mainly cough, phlegm is panted more; Illnesss such as dyspepsia is stagnated, and the gastral cavilty ruffian is full, and abdominal distension is bad.Radish seed also is main medicine in famous prescription Pachyma Compound Digestive Tonic Pill, in order to the treatment dyspepsia.Radish seed is to the effect of stomach and intestine, and radish seed can resist the mouse gastric emptying, can strengthen rabbit ileum rhythmicity and shrink, thereby help digestion and the absorption of nutrition in enteron aisle obviously to the inhibitory action of antiadrenergic drug to intestinal tube.The detoxifcation, radish seed can with diphtheria toxin and tetanus toxin.Anti-inflammatory, radish seed have significant antiinflammatory action, may realize by adrenal gland.Clinical having indigestion, the indigestion and treatment constipation of being used for the treatment of.Eliminate dyspepsia, hyperalimentation, stomach is glutted, and emptying is slowed down, and lacks hunger, indigestion, radish seed and Pachyma Compound Digestive Tonic Pill can help digestion.Its mechanism that helps digestion may to contain digestive ferment relevant with these digestants, regulates gastrointestinal motility with used compound, quicken gastric emptying with logical defecate down also relevant.Radish seed contains significant quantities of fat oil, can the laxation defaecation.The greasy excessive many serious acute complicationses that have of diet are as dilatation of the stomach, pancreatitis, cholecystitis, intestinal obstruction etc.With Chinese medicines such as radish seed, rheum officinale, the barks of official magnolia, can carry out expectant treatment to early stage light disease or simple venereal disease example.
Brush-cherry seed
Seed for rosaceous plant Europe Lee or Yu Li etc.Another name, Yu Zi, Yu Liren, Lee's kernel.The brush-cherry seed flavor is arduous sweet, and property is flat.Relax bowel, the inducing diuresis to reduce edema effect.Can be used for treating diseases such as the dry constipation of intestines, difficult urination, oedema.
Fructus cannabis
Fructus cannabis is the ripening fruits of 1 year living plant hemp Cannabis sativa L. of Moraceae.Also name pockmarks benevolence (treatise on Febrile Diseases), cannabis,fructus (" property of medicine opinion "), winter pockmarks (" dietitian's heart mirror ").It is sweet to distinguish the flavor of, and property is flat.Return spleen, stomach, large intestine channel.Function: moisturize, laxation, treating stranguria, invigorate blood circulation.Cure mainly: the dry constipation of intestines, quench one's thirst, hot pouring, wandering arthritis, dysentery, irregular menstruation, scabies, tinea leprosy.The fatty oil of fructus cannabis seed about 30%.Aliphatic acid in the oil, saturated is 4.9%～9.5%; In the undersaturated aliphatic acid, oleic acid is about 12%, linoleic acid 53%, leukotrienes 25%.Contain cannabinol in the oil.Also contain phytin (phytin), content is 1% in the kind benevolence, is high than content in leaf, stem, the bud.Do not contain micro-alkaloid, muscarine (muscarine), trigonelline (trigonellin), choline etc. are arranged.And contain glucuronic acid, sterol, lecithin and vitamin E
2, Cobastab
1Deng.Fructus cannabis is a traditional Chinese medicine simply, has the effect that relaxes bowel, nourishes qi-restoratives.Modern medicine has proved that its contained fat oil has lubricated intestines wall, the effect of softening stool, slight excited intestinal tube, increase wriggling, the big intestinal absorption moisture of minimizing.
Poria cocos
Dry sclerotia for Polyporaceae plant Poria cocos Poria cocos (Schw.) Wolf.It is sweet, light to distinguish the flavor of, and property is flat.The thoughts of returning home, spleen, lung channel.Function: eliminating dampness and diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Cure mainly: difficult urination, oedema turgor, phlegm and retained fluid are coughed contrary, n and V, are had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Poria cocos mainly contains B-pachyman (B-pachyman), account for 93% of dry weight, triterpene compound pachymic acid (pachymic acid), soil are herded acid (tumulosic acid), triterpene carboxylic acid (triterpene carboxylicacid), eburicoic acid (eburioicacid), loose Siberian cocklebur acid (pinicolic acid) etc.Also fatty acids is as sad (caprylicacid), undecanoic acid (undecanoic acid), laurate (lauric acid), dodecoic acid (dodecenoic acid) and palmitic acid (palmitic acid).In addition, still contain ergosterol (ergosterol), natural gum, chitin, protein, fat, sterol, lecithin, D-glucose, adenine (adenine), histidine (histidine), choline (choline), B-pachyman catabolic enzyme, lipase, protease etc.
In sum, the inventor is according to theory of traditional Chinese medical science at all times, and treatment and protection medication are acted on and taken into account monarch, minister, help, make principle, to reach the purpose of treatment and protection.Through studying the checking of go forward side by side action thing and clinical testing repeatedly, having found finally has the promotion of better effect digestive function nutraceutical.Nutraceutical with promotion digestive function disclosed by the invention, it mainly is the digestants by medicine and food raw materials: six songs, the membrane of a chicken's gizzard, Fructus Hordei Germinatus, hawthorn, radish seed; The medicine that relaxes bowel of medicine and food raw materials: brush-cherry seed, fructus cannabis; Medicine and food raw materials with stomach invigorating the spleen qi-regulating drug: the banksia rose; The sharp water medicine that relieves inflammation or internal heat of medicine and food raw materials: Poria cocos; The medicine-food two-purpose medicine: Chinese yam etc. are prepared from according to a certain weight ratio, and wherein the drug effect with medicine and food raw materials such as six songs, the membrane of a chicken's gizzard, the banksia rose, Poria cocos is a monarch drug in a prescription comprehensively, in order to stomach invigorating the spleen regulate the flow of vital energy and help digestion; For strengthening its effect and increase adaptive surface, Fructus Hordei Germinatus, hawthorn, radish seed, the Chinese yam of adopting medicine and food raw materials again is that minister makes, and strengthens the efficacy of a drug.Assistant relaxes bowel with the brush-cherry seed of medicine and food raw materials, fructus cannabis etc.Above-mentioned various raw material extracts the active component that obtains through taking ethanol-water solution, through experiment confirm repeatedly, six songs of medicament selection medicine and food raw materials of the present invention, Chinese yam, the membrane of a chicken's gizzard, Fructus Hordei Germinatus, hawthorn, the banksia rose, radish seed, brush-cherry seed, fructus cannabis, Poria cocos etc. make up for 10 kinds, make the effect of each medicine and food raw materials produce synergy the combination of these medicine and food raw materials, thereby can effectively show the scope that it promotes digestive function, effect is fairly obvious and rapid.
The prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, powder, tablet, capsule, oral liquid etc., the present invention adopts soft capsule dosage form, dry extract and edible corn ready-mixed oil are mixed at 1: 1.2, and add the beeswax of dry extract weight 2%, incapsulate.Be because the rhythm of life of considering the modern than very fast, adopts the advantage of soft capsule preparation to be exactly: easy to carry, absorb rapidly, this is a kind of more modern modern preparation type that certain technology content is arranged.
By the following examples 1,2,3 and experimental example 1,2 further set forth the effect that nutraceutical of the present invention promotes digestion:
Embodiment 1,
Described nutraceutical, its implementation method should be by the method in foregoing invention content operation, by the weight of its preferred medicine and food raw materials respectively is: six bent 2000g, Chinese yam 2000g, the membrane of a chicken's gizzard 1000g, Fructus Hordei Germinatus 1000g, hawthorn 2000g, banksia rose 1000g, radish seed 1000g, brush-cherry seed 1000g, fructus cannabis 1000g, Poria cocos 1000g.
The preparation method of described nutraceutical should be undertaken by the preparation method in claims and the summary of the invention.
Embodiment 2,
Described nutraceutical, its implementation method should be by the method in summary of the invention operation, by the weight of its preferred medicine and food raw materials respectively is: six bent 4000g, Chinese yam 4000g, the membrane of a chicken's gizzard 2000g, Fructus Hordei Germinatus 2000g, hawthorn 4000g, banksia rose 2000g, radish seed 2000g, brush-cherry seed 2000g, fructus cannabis 2000g, Poria cocos 2000g.
The preparation method of described nutraceutical is with embodiment 1.
Embodiment 3,
Described nutraceutical, its implementation method should be by the method in summary of the invention operation, by the weight of its preferred medicine and food raw materials respectively is: six bent 6000g, Chinese yam 6000g, the membrane of a chicken's gizzard 3000g, Fructus Hordei Germinatus 3000g, hawthorn 6000g, banksia rose 3000g, radish seed 3000g, brush-cherry seed 3000g, fructus cannabis 3000g, Poria cocos 3000g.
The preparation method of described nutraceutical is with embodiment 1.
Experimental example 1,
Promote the nutraceutical of digestion, estimate its function assessment and security toxicology by zoopery.Intestines and stomach are picked-up, the digestion and the organ that absorbs of nutriment, mainly are to rely on that it moves, the secretion of digestive ferment is finished to the digestion of food.If a certain health food can have regulating action to one of them link or several links, it just might have the effect that promotes digestion.Zoopery comprises the mensuration of rat body weight, weight gain, food ration, food utilization, intestinal motility experiment and pepsin activity, discharge rate.Food ration can directly reflect the influence of given the test agent to the animal digestion function.Food utilization food efficiency ratio is represented.Food efficiency ratio=rat experiment phase body weight is gained in weight/rat experiment phase intake in kind.Body weight, weight gain, food efficiency ratio can reflect the digestion and absorption function of animal indirectly.Collect gastric juice with pylorus ligature law, measure pepsin activity with the protein pipe method.The gastric juice discharge rate of pepsin discharge rate=pepsin activity unit * per hour.This index can reflect the influence of given the test agent to the digestion enzyme secretion.The weight of animals, weight gain, food ration, food utilization, intestinal motility experiment and digestive ferment are measured the wantonly two aspect experimental result positives in three aspects, and this given the test agent zoopery of decidable is the positive as a result.
Totally 60 of healthy Male Kunming strain mice are selected in zoopery for use, are divided into 5 groups, every group 12, carry out the intestinal motility experiment, 40 of the healthy male rats of Wistar, be divided into 4 groups, every group 10 mensuration of carrying out body weight, weight gain, food ration, food utilization and digestive ferment.
This nutraceutical promotes digestive function zoopery result (referring to table 1, table 2, table 3, table 4).
This nutraceutical of table 1 is to the influence of the weight of animals, weight gain (X ± SD)
This nutraceutical of table 2 is to the influence of animal ingestion amount, food utilization (X ± SD)
The influence that this nutraceutical of table 3 is tested the animal intestinal motility (X ± SD)
This nutraceutical of table 4 is to the influence of animal digestion enzyme (X ± SD)
This nutraceutical per os gives the 5d of mouse various dose, compares with model control group, and three dosage groups all can improve mouse small intestine exercise testing prepared Chinese ink propelling rate.Weight of mice is had no adverse effects.Per os gives this nutraceutical of rat various dose 30d, and low dose group can improve the rat stomach proteinase activity.The zoopery result to promoting the criterion of digestive function nutraceutical, can determine that this nutraceutical zoopery result shows to have the promotion digestive function according to " health food check and assessment technique standard " (2003 editions).
Experimental example 2,
The acute toxicity test of zooperal security toxicology per os
1. materials and methods
1.1 sample: this nutraceutical.Proterties: brown paste.Lot number: 20070421.Proportion: 1.03g/ml.
Human intaking amount: 1.12g/d.
1.2 solvent: corn oil.
1.3 experimental animal: SPF level ICR kind small white mouse, body weight 18～22 grams.Provide by the department of the Chinese Academy of Sciences of Department Of Medicine, Peking University animal used as test section.The animal quality certification number: SCXX (capital) 2006-0008.Animal is observed and is used for test after 3 days, and animal feeding is in barrier environment.
1.4 animal feed: provide by Beijing section Austria feed corporation,Ltd that pulls together.The feed quality certification number: SCXX (capital) 2005-0007
1.5 test method: row during according to the method for acute toxicity test.Animal is divided into two groups at random, and 20 every group, male and female half and half are divided others' control group and test group.After the animal fasting 16 hours, the test group animal is once irritated stomach with 0.2ml/10g body weight per os and is tried thing stoste.Giving and being tried the agent amount is the 20.6g/kg body weight.Control animals is irritated the corn oil of stomach equivalent.To observing once every day after being tried thing, observe animal poisoning manifestations, death toll and death time.Observed altogether 14 days.Take by weighing and write down the mouse body weight during off-test, put to death animal and perform an autopsy on sb.
2. this nutraceutical is as a result pressed the 20.6g/kg body weight and is given mouse stomach.Observed 14 days, animal does not see obvious toxic reaction symptom.The weight of animals and control group relatively do not have significant difference (seeing Table).
Show of the influence of this nutraceutical to the animal subject body weight
Conclusion:
The acute oral toxicity test result of this nutraceutical shows, two kinds of sex its mouse oral acute toxicity LD
50All greater than the 20.6g/kg body weight.According to " health food check and assessment technique standard " (2003 editions) acute toxicity grading criteria, the true border of this nutraceutical is nontoxic.
Claims (8)
1, a kind of nutraceutical with promotion digestive function and preparation method thereof is mainly made by following medicine and food raw materials in portion by weight: six bent 1-5 parts, Chinese yam 1-5 part, the membrane of a chicken's gizzard 1-5 part, Fructus Hordei Germinatus 1-5 part, hawthorn 1-5 part, banksia rose 1-5 part, radish seed 1-5 part, brush-cherry seed 1-5 part, fructus cannabis 1-5 part, Poria cocos 1-5 part.
2, nutraceutical according to claim 1, the weight portion of its preferred medicine and food raw materials is: six 2 parts of songs, 2 parts of Chinese yams, 1 part of the membrane of a chicken's gizzard, 1 part in Fructus Hordei Germinatus, 2 parts of hawthorn, 1 part of the banksia rose, 1 part of radish seed, 1 part of brush-cherry seed, 1 part of fructus cannabis, 1 part in Poria cocos.
3, the preparation method of nutraceutical according to claim 1 and 2:
(1) take by weighing the banksia rose, radish seed, brush-cherry seed, fructus cannabis, Poria cocos etc. 5 flavor medicine and food raw materials in proportion, extract and use 70% alcohol extract, refluxed 3 hours, extract secondary, merging extract vacuum concentrated dry extract 1;
(2) take by weighing Chinese yam, the membrane of a chicken's gizzard etc. 2 flavor medicine and food raw materials in proportion, use 90% alcohol extract, refluxed 3 hours, the extraction secondary, with the extract vacuum concentrated dry extract 2;
(3) take by weighing six songs, Fructus Hordei Germinatus, hawthorn etc. 3 flavor medicine and food raw materials in proportion, extract, refluxed 3 hours, extract secondary with distilled water, with the extract vacuum concentrated dry extract 3;
4, merge dry extract 1,2,3, it is ground into 200 order powder, be active component of the present invention.Press the method for production of soft capsule, be filled into capsule shells.
To reclaim ethanol and concentrated during 5, with alcohol extract, concentrate and adopt vacuum to concentrate.Vacuum concentrates and claims decompression to concentrate again, and vacuum concentrates has lot of advantages.Not only can save a large amount of energy.Simultaneously,, avoided the destruction and the loss of thermally labile component, preserved material nutrient component and fragrance better because material is not subjected to temperatures involved.
6, preparation method according to claim 3, the dry extract that obtains after described the concentrating also need is following dry 3 hours at 50-60 ℃.
7, claim 1,2,3,4 described nutraceutical, its formulation is a soft capsule.
8, the prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, electuary, tablet, capsule, oral liquid etc.
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| CN102188649A (en) * | 2011-05-16 | 2011-09-21 | 高兵 | Preparation method of traditional Chinese medicine for treating meat-accumulation type hyperlipidemia |
| CN102396708A (en) * | 2011-11-04 | 2012-04-04 | 黎秋萍 | Food for treating child anorexia |
| CN103191391A (en) * | 2013-03-19 | 2013-07-10 | 高丽超 | Tradtional Chinese medicine for treating chronic gastritis |
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| CN104921114A (en) * | 2015-05-28 | 2015-09-23 | 合肥市开平食品贸易有限责任公司 | Health-care food formula capable of improving digestion and preparation method thereof |
| CN105412305A (en) * | 2015-12-11 | 2016-03-23 | 蓬溪发联农牧有限公司 | Compound traditional Chinese medicine for treating flatulence and diarrhea of rabbits as well as application method of compound traditional Chinese medicine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102188649A (en) * | 2011-05-16 | 2011-09-21 | 高兵 | Preparation method of traditional Chinese medicine for treating meat-accumulation type hyperlipidemia |
| CN102396708A (en) * | 2011-11-04 | 2012-04-04 | 黎秋萍 | Food for treating child anorexia |
| CN103191391A (en) * | 2013-03-19 | 2013-07-10 | 高丽超 | Tradtional Chinese medicine for treating chronic gastritis |
| CN103271184A (en) * | 2013-06-19 | 2013-09-04 | 山东华夏茶联茶业有限公司 | Health yellow tea |
| CN103271184B (en) * | 2013-06-19 | 2014-12-31 | 山东华夏茶联茶业有限公司 | Health yellow tea |
| CN104921114A (en) * | 2015-05-28 | 2015-09-23 | 合肥市开平食品贸易有限责任公司 | Health-care food formula capable of improving digestion and preparation method thereof |
| CN105412305A (en) * | 2015-12-11 | 2016-03-23 | 蓬溪发联农牧有限公司 | Compound traditional Chinese medicine for treating flatulence and diarrhea of rabbits as well as application method of compound traditional Chinese medicine |
| CN107319426A (en) * | 2017-08-21 | 2017-11-07 | 安徽先知缘食品有限公司 | A kind of stomach strengthening and digestion promoting can and preparation method thereof |
| CN108785522A (en) * | 2018-07-10 | 2018-11-13 | 石俊杰 | A kind of herbal medicine promoting digestion |
| CN109275824A (en) * | 2018-10-22 | 2019-01-29 | 杭州千岛湖标普健康食品有限公司 | A kind of toxin-expelling and face nourishing hypolipemic function solid beverage and preparation method thereof |
| CN113769029A (en) * | 2021-10-09 | 2021-12-10 | 谷晓红 | Medicinal and edible herbal composition for improving intestinal absorption and immune function |
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