CN113710655A - 氟哌啶醇的纯化方法 - Google Patents

氟哌啶醇的纯化方法 Download PDF

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Publication number
CN113710655A
CN113710655A CN202080025740.4A CN202080025740A CN113710655A CN 113710655 A CN113710655 A CN 113710655A CN 202080025740 A CN202080025740 A CN 202080025740A CN 113710655 A CN113710655 A CN 113710655A
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China
Prior art keywords
haloperidol
purifying
dimeric
dmso solution
dmso
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CN202080025740.4A
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CN113710655B (zh
Inventor
陈小林
杨易可
占娅锋
高鹏飞
孙晔
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Shanghai Xudong Haipu Pharmaceutical Co ltd
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Shanghai Xudong Haipu Pharmaceutical Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

一种氟哌啶醇的纯化方法，先将制得的氟哌啶醇粗品溶于热的DMSO溶液中，过滤除掉不溶于DMSO的二聚杂质，即得二聚杂质含量合格的氟哌啶醇。本发明提供的氟哌啶醇的纯化方法，将制得的氟哌啶醇粗品加入热的DMSO溶液中实现了将合成中产生的二聚杂质高效除去，使得所得氟哌啶醇的二聚杂质含量低于0.05w/w％。

Description

PCT国内申请，说明书已公开。

Claims (7)

  1. PCT国内申请，权利要求书已公开。
CN202080025740.4A 2019-04-22 2020-01-13 氟哌啶醇的纯化方法 Active CN113710655B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910328146.1A CN109970624B (zh) 2019-04-22 2019-04-22 氟哌啶醇的纯化方法
CN2019103281461 2019-04-22
PCT/CN2020/071676 WO2020215835A1 (zh) 2019-04-22 2020-01-13 氟哌啶醇的纯化方法

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CN113710655A true CN113710655A (zh) 2021-11-26
CN113710655B CN113710655B (zh) 2023-08-11

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CN202080025740.4A Active CN113710655B (zh) 2019-04-22 2020-01-13 氟哌啶醇的纯化方法

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WO (1) WO2020215835A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109970624B (zh) * 2019-04-22 2020-05-22 上海旭东海普药业有限公司 氟哌啶醇的纯化方法
CN112538042A (zh) * 2020-12-15 2021-03-23 湖南洞庭药业股份有限公司 一种氟哌啶醇的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086234A (en) * 1975-11-07 1978-04-25 G. D. Searle & Co. Process for the preparation of tertiary amines
US5583000A (en) * 1991-09-03 1996-12-10 The Regents Of The University Of California Protease-binding compounds and methods of use
US20190015400A1 (en) * 2017-07-17 2019-01-17 University Of Kentucky Research Foundation Antifungal Compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109970624B (zh) * 2019-04-22 2020-05-22 上海旭东海普药业有限公司 氟哌啶醇的纯化方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086234A (en) * 1975-11-07 1978-04-25 G. D. Searle & Co. Process for the preparation of tertiary amines
US5583000A (en) * 1991-09-03 1996-12-10 The Regents Of The University Of California Protease-binding compounds and methods of use
US20190015400A1 (en) * 2017-07-17 2019-01-17 University Of Kentucky Research Foundation Antifungal Compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XIAHENG ZHANG 等: "Direct Aldehyde C-H Arylation and Alkylation via the Combination", 《J.AM.CHEM.SOC.》, vol. 139, pages 44 - 45 *

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Publication number Publication date
CN113710655B (zh) 2023-08-11
CN109970624A (zh) 2019-07-05
CN109970624B (zh) 2020-05-22
WO2020215835A1 (zh) 2020-10-29

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