CN101987136B - Medicine for treating neurodermatitis and preparation method thereof - Google Patents
Medicine for treating neurodermatitis and preparation method thereof Download PDFInfo
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- CN101987136B CN101987136B CN2010102649314A CN201010264931A CN101987136B CN 101987136 B CN101987136 B CN 101987136B CN 2010102649314 A CN2010102649314 A CN 2010102649314A CN 201010264931 A CN201010264931 A CN 201010264931A CN 101987136 B CN101987136 B CN 101987136B
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Abstract
The invention discloses a medicine for treating neurodermatitis, which is characterized by being prepared from the following main raw materials in parts by weight: 1-20 parts of rose, 1-20 parts of seville orange flower, 1-20 parts of prepared tuber fleeceflower root, 1-20 parts of bark of peony tree, 1-20 parts of rehmannia root, 1-20 parts of prepared rehmannia root, 1-20 parts of Chinese angelica, 1-20 parts of red flower, 1-20 parts of belvedere fruit, 1-20 parts of tribulus terrestris, 1-20 parts of stiff silkworm, 1-20 parts of figwort root, 1-20 parts of liquorice and 1-20 parts of edible alcohol with the content above 95 percent. The medicine can be absorbed via the spleen and the stomach through oral administration and via the skin through external use, and can also be absorbed in a combinational way through the oral administration and the external use. The medicine of the invention has the advantages of reasonable formulation, simplified medicine compatibility and definite curative effect, can be used for treating the principal and secondary aspects of a disease and is suitable for the neurodermatitis and particularly for dispersion type damage cases. The invention further provides a preparation method of the medicine.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment neurodermatitis of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Neurodermatitis is claimed lichen chronicus simplex again, is the chronic dermatosis that turns to characteristic with paroxysmal skin pruritus and skin lichen, is common multiple cutaneous disease.Be more common in youth and adult.Mostly occur at nape or its both sides, the fossa cubitalis, state's nest, forearm, thigh, shank and lumbosacral region etc.Normal appearance in flakes, triangular in shape or polygonal flat-top pimple, pachyderma, skin ridge projection, sulci of skin is deepened, the likeness in form lichen.Be light red or filbert; Acutely scratching where it itches is its The main symptoms.Have than obvious damage person like whole skin, be referred to as diffuse neurodermitis again.It is relevant with neural Nervous and Mental Factors and some external stimulus factor to fall ill.The chronic process of neurodermatitis is not inclined to moisteningly, is easy to show effect repeatedly.
The traditional Chinese medical science is thought: this disease mainly with interior because main because mind bothers, internal injury caused by excess of seven emotions, interior living heart-fire and causing.Redder from the beginning of erythra, pruritus is acute, and because of heart governing blood and vessels, hyperactivity of heart-fire lies prostrate in nutrient blood, produces heat in blood, the blood hot air wind producing, and wind is contained then dry, belongs to the heat in blood wind-dryness.For a long time sick, skin lesion is plump, and unity and coherence in writing is big and heavy, is the lichenization person, and this is because of the prolonged illness blood trouble, and wind is contained then dry, belongs to blood-deficiency and wind-dry.
One Chinese patent application CN200710132778.8 discloses a kind of Chinese medicine of treating neurodermatitis, comprises Hydrargyri Oxydum Rubrum frost 3 grams, Alumen 6 grams, Shrubalthea Bark, Semen Armeniacae Amarum, each 10 gram of Lithargyrum.Pulverize during use, add Ovum Gallus domesticus album and be applied in the affected part.One Chinese patent application CN200710120975.8 discloses a kind of Chinese medicine composition, and it is to be raw material with 10 Chinese medicine medicines such as Ramulus Uncariae Cum Uncis, Cortex Albiziae, Radix Salviae Miltiorrhizae and Fructus Lycii, and decocting boils into decoction.One Chinese patent application CN200810139182.5 discloses a kind of Chinese medicine of treating neurodermatitis, and it is made up of the Radix Astragali, Radix Codonopsis, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Semen Nelumbinis, Semen Coicis, Herba Schizonepetae, Fructus Cnidii, Fructus Arctii, the Fructus Kochiae, Periostracum Cicadae Chinese herbal medicine.
The Chinese medicine product of above-mentioned treatment neurodermatitis is too much paid attention to regulating, and has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable.And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to the decoction or the pill that are mostly to boil than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists; A kind of reasonable recipe is provided; Compatibility is simplified, the medicine of the treatment neurodermatitis of determined curative effect, treating both the principal and secondary aspects of a disease, is main to control, and controls to support to combine; And this medicine can take orally through taste absorb again can external through skin absorbs, can also oral administration and externally used dual mode composite absorbent.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is following:
A kind of medicine of treating neurodermatitis is characterized in that it mainly is to be processed by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of Citrus aurantium L. var. amara Engl., 1 ~ 20 part of Radix Polygoni Multiflori Preparata; 1 ~ 20 part of Cortex Moutan, 1 ~ 20 part in the Radix Rehmanniae, 1 ~ 20 part in Radix Rehmanniae Preparata, 1 ~ 20 part of Radix Angelicae Sinensis; 1 ~ 20 part on Flos Carthami, 1 ~ 20 part of the Fructus Kochiae, 1 ~ 20 part of Fructus Atriplicis Sibiricae, 1 ~ 20 part of Bombyx Batryticatus; 1 ~ 20 part of Radix Scrophulariae, 1 ~ 20 part in Radix Glycyrrhizae, 1 ~ 20 part of the edible ethanol of content more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of Citrus aurantium L. var. amara Engl.s, 15 ~ 20 parts of Radix Polygoni Multiflori Preparatas; 15 ~ 20 parts of Cortex Moutans, 15 ~ 20 parts in the Radix Rehmanniae, 15 ~ 20 parts in Radix Rehmanniae Preparata, 15 ~ 20 parts of Radix Angelicae Sinensis; 15 ~ 20 parts on Flos Carthami, 15 ~ 20 parts of the Fructus Kochiae, 15 ~ 20 parts of Fructus Atriplicis Sibiricaees, 15 ~ 20 parts of Bombyx Batryticatus; 15 ~ 20 parts of Radix Scrophulariaes, 15 ~ 20 parts in Radix Glycyrrhizae, 15 ~ 20 parts of the edible ethanol of content more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing said weight proportion Flos Rosae Rugosae, Citrus aurantium L. var. amara Engl., Radix Polygoni Multiflori Preparata, Cortex Moutan, the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis; Flos Carthami, the Fructus Kochiae, Fructus Atriplicis Sibiricae, Bombyx Batryticatus, Radix Scrophulariae and Radix Glycyrrhizae; According to the conventional method for distilling of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add the edible ethanol of content more than 95% of said weight proportion, be mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrating sterilization, fill according to quantity must be treated the medicine of neurodermatitis.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional method for distilling of said Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to the characteristics of neurodermatitis; Select for use Flos Rosae Rugosae, Citrus aurantium L. var. amara Engl., Radix Polygoni Multiflori Preparata, Cortex Moutan, the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis; Flos Carthami, the Fructus Kochiae, Fructus Atriplicis Sibiricae, Bombyx Batryticatus, Radix Scrophulariae, Radix Glycyrrhizae; With being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction, process to contain pure Chinese medicine extraction liquid.Employing is main to control, and control the bonded method of supporting, but not only also external of oral administration of the medicine of processing is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment neurodermatitis of determined curative effect, treating both the principal and secondary aspects of a disease.
The Cortex Moutan cold nature, bitter in the mouth is hot, and is nontoxic, goes into the heart, liver, kidney channel, has to purify the blood the function of promoting blood circulation to remove blood stasis.The Radix Rehmanniae is cool in nature, and sweet in the mouth is gone into the heart, liver, kidney channel, nourishing YIN and clearing away heat; Removing heat from blood is enriched blood.Radix Rehmanniae Preparata property is sweet, and tepor is gone into liver, kidney channel; The YIN nourishing of enriching blood, vital essence replenishing and marrow benifiting.The sweet suffering of Radix Angelicae Sinensis property, temperature is gone into the heart, liver, spleen channel; Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving is moisturized laxation.The Flos Carthami nature and flavor are hot, temperature.Go into the heart, Liver Channel; Promoting blood circulation to restore menstrual flow, the blood stasis removing pain relieving.Fructus Kochiae nature and flavor sweetness and bitterness, cold, go into kidney, urinary bladder channel; Diuresis, clearing away damp-heat.The Fructus Atriplicis Sibiricae nature and flavor are bitter, hot, and are flat, return Liver Channel, suppressing liver-YANG, and dispersing the stagnated live-QI to relieve the stagnation of QI makes eye bright, dispelling wind for relieving itching.The Bombyx Batryticatus nature and flavor are salty, hot, and are flat, return liver, lung, stomach warp; Expelling wind for relieving convulsion, dissipating phlegm and resolving masses.The Radix Scrophulariae nature and flavor are bitter, sweet, salty, cold, return lung, stomach, kidney channel; Clearing away heat and cooling blood, detoxicating and resolving stagnation of pathogens, Yin-nourishing and body fluid promoting.The Radix Glycyrrhizae nature and flavor are sweet, and are flat, go into spleen, stomach, lung meridian; With middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.
The present invention is with the Fructus Kochiae, Fructus Atriplicis Sibiricae, Bombyx Batryticatus dispelling wind for relieving itching; Radix Polygoni Multiflori Preparata, Cortex Moutan, the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Flos Carthami removing heat from blood and promoting blood circulation; Radix Scrophulariae, Radix Glycyrrhizae invigorating spleen to remove dampness share the merit of playing the removing heat from blood that dispels the wind, invigorating spleen to remove dampness altogether.Medicine of the present invention is applicable to that neurodermatitis, the outstanding type of sending out that is suitable for damage case, and effect is better.
Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The Citrus aurantium L. var. amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two to be transferred, eliminating turbid pathogen with aromatics, the appetizing of being amusing, the strength enhancing that absorbs the drug when oral.The edible ethanol blood circulation promoting and blood stasis dispelling of content more than 95% promotes that drug osmotic to cell absorbs, and auxiliary taste absorb to improve curative effect when oral; Outer time spent skin expansion pore is to strengthen the drug transdermal trap.
Medicine of the present invention can also be smeared the affected part with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the patient suffering, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is obvious that the present invention treats the neurodermatitis curative effect, and clinical usefulness repeatly, effect are very prompt.Treat 54 examples with clinical drug of the present invention, result's 49 examples (accounting for 90.7%) of fully recovering, effective 5 examples.Total effective rate reaches 100%.Cure continued and take we, can consolidate curative effect.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, to enumerate model case following at present:
Case 1: certain woman 52 years old, pale red flat-top pimple appears in many places such as cervical region and forearm, the violent pruritus of paroxysmal, psychentonia increases the weight of, and is neurodermatitis after diagnosing.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above symptom was alleviated in 3 days, eliminated in 17 days.Paying a return visit after 12 months does not have recurrence.
Case 2: certain man 57 years old, the flat-top pimple appears in many places such as forearm, thigh and shank, and the violent pruritus of paroxysmal is neurodermatitis after diagnosing.External medicine whole body of the present invention with smear the affected part, every day 2 times, each 10 milliliters, repeatedly smear in the affected part.Above symptom was alleviated in 2 days, eliminated in 13 days.Paying a return visit after 12 months does not have recurrence.
Case 3: certain man 39 years old, suffer from the neurodermatitis several years, pachylosis is plump, violent pruritus, neurosis.Once took the Chinese medicine of multiple treatment neurodermatitis, but effect is all not good.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body and affected part, and every day 2 times, each 10 milliliters, repeatedly smear at the place, affected part.Above symptom is oral to be alleviated with external in 1 day, eliminated in 10 days.Paying a return visit after 12 months does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of Citrus aurantium L. var. amara Engl.s, 18 parts of Radix Polygoni Multiflori Preparatas, 17 parts of Cortex Moutans; 17 parts in the Radix Rehmanniae, 19 parts in Radix Rehmanniae Preparata, 20 parts of Radix Angelicae Sinensis, 20 parts on Flos Carthami; 16 parts of the Fructus Kochiae, 16 parts of Fructus Atriplicis Sibiricaees, 18 parts of Bombyx Batryticatus, 19 parts of Radix Scrophulariaes; 19 parts in Radix Glycyrrhizae adopts the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and is subsequent use.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the treatment neurodermatitis of oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, 19 parts of Citrus aurantium L. var. amara Engl.s, 18 parts of Radix Polygoni Multiflori Preparatas, 19 parts of Cortex Moutans, 18 parts in the Radix Rehmanniae; 20 parts in Radix Rehmanniae Preparata, 19 parts of Radix Angelicae Sinensis, 19 parts on Flos Carthami, 20 parts of the Fructus Kochiae, 18 parts of Fructus Atriplicis Sibiricaees; 18 parts of Bombyx Batryticatus, 19 parts of Radix Scrophulariaes, 20 parts in Radix Glycyrrhizae, content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, 20 parts of Citrus aurantium L. var. amara Engl.s, 19 parts of Radix Polygoni Multiflori Preparatas, 20 parts of Cortex Moutans, 20 parts in the Radix Rehmanniae; 20 parts in Radix Rehmanniae Preparata, 19 parts of Radix Angelicae Sinensis, 19 parts on Flos Carthami, 20 parts of the Fructus Kochiae, 19 parts of Fructus Atriplicis Sibiricaees; 19 parts of Bombyx Batryticatus, 20 parts of Radix Scrophulariaes, 19 parts in Radix Glycyrrhizae, content is 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, 15 parts of Citrus aurantium L. var. amara Engl.s, 16 parts of Radix Polygoni Multiflori Preparatas, 16 parts of Cortex Moutans, 15 parts in the Radix Rehmanniae; 17 parts in Radix Rehmanniae Preparata, 16 parts of Radix Angelicae Sinensis, 15 parts on Flos Carthami, 16 parts of the Fructus Kochiae, 17 parts of Fructus Atriplicis Sibiricaees; 18 parts of Bombyx Batryticatus, 17 parts of Radix Scrophulariaes, 18 parts in Radix Glycyrrhizae, content is 16 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, 19 parts of Citrus aurantium L. var. amara Engl.s, 20 parts of Radix Polygoni Multiflori Preparatas, 17 parts of Cortex Moutans, 19 parts in the Radix Rehmanniae; 18 parts in Radix Rehmanniae Preparata, 17 parts of Radix Angelicae Sinensis, 18 parts on Flos Carthami, 17 parts of the Fructus Kochiae, 20 parts of Fructus Atriplicis Sibiricaees; 18 parts of Bombyx Batryticatus, 20 parts of Radix Scrophulariaes, 18 parts in Radix Glycyrrhizae, content is 19 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, 19 parts of Citrus aurantium L. var. amara Engl.s, 19 parts of Radix Polygoni Multiflori Preparatas, 18 parts of Cortex Moutans, 18 parts in the Radix Rehmanniae; 17 parts in Radix Rehmanniae Preparata, 20 parts of Radix Angelicae Sinensis, 17 parts on Flos Carthami, 19 parts of the Fructus Kochiae, 20 parts of Fructus Atriplicis Sibiricaees; 18 parts of Bombyx Batryticatus, 18 parts of Radix Scrophulariaes, 18 parts in Radix Glycyrrhizae, content is 20 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (1)
1. medicine of treating neurodermatitis is characterized in that being processed by following method:
(1) takes by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of Citrus aurantium L. var. amara Engl.s, 18 parts of Radix Polygoni Multiflori Preparatas, 17 parts of Cortex Moutans; 17 parts in the Radix Rehmanniae, 19 parts in Radix Rehmanniae Preparata, 20 parts of Radix Angelicae Sinensis, 20 parts on Flos Carthami; 16 parts of the Fructus Kochiae, 16 parts of Fructus Atriplicis Sibiricaees, 18 parts of Bombyx Batryticatus, 19 parts of Radix Scrophulariaes; 19 parts in Radix Glycyrrhizae adopts the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and is subsequent use;
(2) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use;
(3) above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the treatment neurodermatitis of for oral administration or external carries out fill under aseptic condition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102649314A CN101987136B (en) | 2010-08-27 | 2010-08-27 | Medicine for treating neurodermatitis and preparation method thereof |
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| CN101987136B true CN101987136B (en) | 2012-12-19 |
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| CN103393816A (en) * | 2013-08-22 | 2013-11-20 | 王爱枝 | Medicine for treating dermatitis, and preparation method of medicine |
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Non-Patent Citations (7)
| Title |
|---|
| 南京中医药大学.玫瑰花 |
| 南京中医药大学.玫瑰花;玳玳花.《中药大辞典》.上海科学技术出版社,2006,1745-1748,2098. * |
| 张兆旺，等.中药合剂（含口服液） |
| 张兆旺,等.中药合剂(含口服液)渗透促进剂.《中药药剂学》.中国中医药出版社,2002,103-105,185-187. * |
| 渗透促进剂.《中药药剂学》.中国中医药出版社,2002,103-105，185-187. |
| 玳玳花.《中药大辞典》.上海科学技术出版社,2006,1745-1748，2098. |
| 贾炳贤.首乌饮.《贾氏益寿美容验方选》.中国医药科技出版社,2006,100. * |
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