CN113633724A - Traditional Chinese medicine mixture for treating calculus removal and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine mixture for treating calculus removal and a preparation method thereof, wherein the mixture is prepared from the following raw material medicines in parts by weight: 16 g of herba pyrrosiae, 20 g of fried chicken's gizzard-membrane, 12 g of longhairy antenoron herb, 10 g of dried rehmannia root, 12 g of cluster mallow seed, 6 g of akebia stem, 10 g of peach seed, 10 g of tuckahoe, 10 g of achyranthes root, 16 g of raw liquorice, 12 g of talcum, 12 g of climbing fern spore, 10 g of rhizoma alismatis, 10 g of lalang grass rhizome, 6 g of scutellaria baicalensis, 6 g of combined spicebush root and 9 g of cortex moutan. The invention has scientific and reasonable formula, novel and reasonable preparation method, high precision of process parameters, less component loss and stable drug effect, is suitable for various urinary calculi diseases such as kidney calculi, urethral calculi and the like, is not easy to relapse after being cured, and meets the requirement of clinical treatment.

Description

Traditional Chinese medicine mixture for treating calculus removal and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine mixture for treating calculus removal and a preparation method thereof.

Background

Urinary calculus is a common disease in urology surgery, and the domestic incidence rate is high. Although various means are applied to clinical treatment at present and good effects are obtained, such as external shock wave lithotripsy, ureteroscope, percutaneous nephroscope, ultrasonic lithotripsy, laser lithotripsy and the like, the postoperative calculus residue rate and the calculus recurrence rate are still high. At present, patients suitable for non-operative therapy generally adopt traditional Chinese medicine for adjuvant therapy, and traditional Chinese medicines for treating calculus in the prior art are rare and have unobvious curative effect. Therefore, it is very necessary to develop a Chinese medicinal mixture for effectively treating calculus.

Disclosure of Invention

The invention aims to make up the defects of the prior art and provides a traditional Chinese medicine mixture for treating calculus removal and a preparation method thereof.

The invention is realized by the following technical scheme:

a traditional Chinese medicine mixture for treating calculus removal is prepared from the following raw material medicines in parts by weight:

14-18 g of herba pyrrosiae, 18-22 g of fried chicken's gizzard-membrane, 10-14 g of longhairy antenoron herb, 8-12 g of dried rehmannia root, 10-14 g of cluster mallow seed, 4-8 g of akebia stem, 8-12 g of peach seed, 8-12 g of tuckahoe, 8-12 g of achyranthes root, 14-18 g of raw liquorice, 10-14 g of talcum, 10-14 g of lygodium japonicum, 8-12 g of rhizoma alismatis, 8-12 g of cogongrass rhizome, 4-8 g of scutellaria baicalensis, 4-8 g of combined spicebush root and 7-11 g of cortex moutan.

The mixture is prepared from the following raw material medicines in parts by weight:

16 g of herba pyrrosiae, 20 g of fried chicken's gizzard-membrane, 12 g of longhairy antenoron herb, 10 g of dried rehmannia root, 12 g of cluster mallow seed, 6 g of akebia stem, 10 g of peach seed, 10 g of tuckahoe, 10 g of achyranthes root, 16 g of raw liquorice, 12 g of talcum, 12 g of climbing fern spore, 10 g of rhizoma alismatis, 10 g of lalang grass rhizome, 6 g of scutellaria baicalensis, 6 g of combined spicebush root and 9 g of cortex moutan.

A preparation method of a traditional Chinese medicine mixture for treating calculus removal comprises the following steps:

(1) mixing the pyrrosia leaf, the fried chicken's gizzard-membrane, the longhairy antenoron herb, the dried rehmannia root, the cluster mallow fruit, the akebia stem, the peach kernel, the poria cocos, the achyranthes bidentata, the raw liquorice, the talc, the climbing fern spore, the rhizoma alismatis, the lalang grass rhizome, the scutellaria baicalensis, the combined spicebush root and the tree peony bark, soaking the mixture in 20-30 parts of water for 1 hour, decocting the mixture at 180-200 ℃ for 30-60 min, filtering decoction, adding 10-20 parts of water into filter residue, decocting the mixture at 180-200 ℃ for 30-60 min, filtering the decoction, and combining the two decoctions;

(2) and (2) carrying out reflux extraction on the decoction liquid combined in the step (1) twice with water at 100 ℃, each time for 3 hours, carrying out vacuum concentration on the extracting solution, adding absolute ethyl alcohol, carrying out overnight precipitation at 4-20 ℃, taking the filtrate, and concentrating the filtrate at 70-80 ℃ to 1/3-1/4 of the original volume to obtain the traditional Chinese medicine mixture.

The traditional Chinese medicine used in the invention comprises:

the herba pyrrosiae is a perennial herb of the Spiraeae family, and has bitter and mild taste. Enter lung and bladder meridians, induce diuresis to treat stranguria, clear lung-heat and purge heat. It can be used for treating stranguria, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung heat, chronic tracheitis, incised wound, and superficial infection.

Endothelium corneum Gigeriae Galli is inner wall of dry ballast of domestic chicken of Phasianidae, sweet and flat. It enters spleen, stomach, small intestine and bladder meridians. Strengthening the stomach to promote digestion, arresting seminal emission and relieving enuresis, and treating stranguria and removing calculus.

Herba Lysimachiae Christinae is fresh or dried whole herb of herba Lysimachiae Christinae of genus Lysimachia of family Primulaceae, and is bitter, sour and slightly cold in taste. It enters liver, gallbladder, kidney and bladder meridians. Has the functions of clearing away heat and toxic material, promoting urination, removing urinary calculus, promoting blood circulation and dissipating blood stasis.

Radix rehmanniae, which has cool nature and sweet and bitter taste and is responsible for heart, liver and kidney channels, has the efficacies of nourishing yin and tonifying kidney, nourishing blood and enriching blood and cooling blood. It is beneficial to be taken by patients with yin deficiency, blood deficiency and kidney deficiency. In addition, rehmanniae radix has effects of tonifying heart, promoting diuresis, relieving fever, relieving inflammation, promoting blood coagulation and reducing blood sugar.

The semen Abutili belongs to large intestine, small intestine and bladder channels, has effects of promoting diuresis for treating stranguria, smoothing intestine, relaxing bowels and promoting lactation, and can be used for treating gonorrhea, edema, constipation and galactostasis.

Akebia stem, sweet in taste and slightly cold in nature, has the main effects of warming dark urine, treating stranguria with pain, edema, oliguria and agalactia.

Tao ren, entering heart, liver and large intestine meridians. Promote blood circulation to remove blood stasis, moisten intestines to relieve constipation, relieve cough and relieve asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, constipation due to intestinal dryness, cough, and asthma.

Poria is dry sclerotium of Poria cocos (Schw.) wolf of Polyporaceae, and has warm nature and light taste, and can enter heart, spleen and lung channels, eliminate dampness, promote diuresis, benefit spleen and stomach, and tranquilize heart and mind.

Radix Achyranthis bidentatae, with bitter and sour flavor, is mainly used for treating flaccidity and arthralgia due to cold-dampness, spasm of limbs, difficulty in flexion and extension of knee, blood and qi movement, injury, heat and fire decay, weight loss and aging resistance after long-term use. It is good at tonifying liver and kidney, strengthening waist and knee joints, promoting blood circulation and inducing blood to flow downwards. Is suitable for patients with cholelithiasis, nephrolithiasis, vesical calculus and urethral calculus.

The raw licorice root is the dry product of the root and rhizome of the medicinal plant licorice root, has sweet and mild taste and enters spleen, stomach and lung channels. Replenishing qi and strengthening the middle warmer; relieving spasm and pain; moistening lung to arrest cough; purging pathogenic fire and removing toxic substances; harmonize the drugs.

Talc is a common silicate mineral, sweet, bland and cold. It enters bladder, lung and stomach meridians. Induce diuresis to treat stranguria, clear away summer-heat, dispel dampness and heal wound. Can be used for treating pyretic stranguria, urolithiasis, odynuria, summer-heat dampness polydipsia, damp-heat watery diarrhea; it can be used for treating eczema, and miliaria.

Spora Lygodii is dry mature spore of spora Lygodii of the family Lygodiaceae, and has sweet, salty and cold properties. It enters bladder and small intestine meridians. Clear damp-heat, relieve stranguria and alleviate pain. Can be used for treating pyretic stranguria, urolithic stranguria, bloody stranguria, chylous stranguria, and urethral astringency and pain.

Rhizoma alismatis is sweet and light in flavor and cold in nature; it enters kidney and bladder meridians. Has the effects of promoting diuresis, eliminating dampness, clearing heat and treating stranguria. It can be used for treating dysuria, pyretic stranguria, odynuria, edema, diarrhea, phlegm retention, vertigo, and spermatorrhea.

The cogongrass rhizome enters lung, stomach and bladder channels, cools blood and stops bleeding, clears heat and promotes urination. Can be used for treating hematemesis due to blood heat, epistaxis, hematuria, fever polydipsia, cough due to lung heat, stomach heat emesis, jaundice due to damp-heat pathogen, edema oliguria, stranguria with astringency and pain.

Scutellariae radix has effects of clearing heat and eliminating dampness, clearing pathogenic fire and removing toxic substance, stopping bleeding, and preventing miscarriage, and can be used for treating damp warmth, summer dampness, chest distress and nausea, damp heat and fullness, dysentery, jaundice, cough due to lung heat, hyperpyrexia and polydipsia, blood heat and epistaxis, carbuncle, swelling, sore and toxin, and threatened abortion.

Wu Yao, entering lung, spleen, kidney and bladder meridians. Move qi and alleviate pain, warm kidney and dispel cold. Can be used for treating cold accumulation, qi stagnation, chest and abdomen distention and pain, asthma, bladder deficiency cold, enuresis, pollakisuria, hernia pain, and cold abdominal pain.

Cortex moutan has central inhibitory effects of tranquilizing, cooling, relieving fever, relieving pain, relieving spasm, etc., and has effects of resisting atherosclerosis, diuresis, and ulcer.

The invention has the advantages that: the invention has scientific and reasonable formula, novel and reasonable preparation method, high precision of process parameters, less component loss and stable drug effect, is suitable for various urinary calculi diseases such as kidney calculi, urethral calculi and the like, is not easy to relapse after being cured, and meets the requirement of clinical treatment; the formula is summarized by years of clinical practice, and has the effects of clearing heat, promoting diuresis, removing blood stasis and relieving pain; the traditional Chinese medicinal materials selected by the invention are safe, have no side effect, can be taken for a long time and can regulate the physical function of patients.

Detailed Description

A traditional Chinese medicine mixture for treating calculus removal is prepared from the following raw material medicines in parts by weight:

16 g of herba pyrrosiae, 20 g of fried chicken's gizzard-membrane, 12 g of longhairy antenoron herb, 10 g of dried rehmannia root, 12 g of cluster mallow seed, 6 g of akebia stem, 10 g of peach seed, 10 g of tuckahoe, 10 g of achyranthes root, 16 g of raw liquorice, 12 g of talcum, 12 g of climbing fern spore, 10 g of rhizoma alismatis, 10 g of lalang grass rhizome, 6 g of scutellaria baicalensis, 6 g of combined spicebush root and 9 g of cortex moutan.

A preparation method of a traditional Chinese medicine mixture for treating calculus removal comprises the following steps:

(1) mixing the pyrrosia leaf, the fried chicken's gizzard-membrane, the longhairy antenoron herb, the dried rehmannia root, the cluster mallow fruit, the akebia stem, the peach kernel, the poria cocos, the achyranthes bidentata, the raw liquorice, the talc, the climbing fern spore, the rhizoma alismatis, the lalang grass rhizome, the scutellaria baicalensis, the combined spicebush root and the tree peony bark, soaking the mixture in 20-30 parts of water for 1 hour, decocting the mixture at 180-200 ℃ for 30-60 min, filtering decoction, adding 10-20 parts of water into filter residue, decocting the mixture at 180-200 ℃ for 30-60 min, filtering the decoction, and combining the two decoctions;

(2) and (2) carrying out reflux extraction on the decoction liquid combined in the step (1) twice with water at 100 ℃, each time for 3 hours, carrying out vacuum concentration on the extracting solution, adding absolute ethyl alcohol, carrying out overnight precipitation at 4-20 ℃, taking the filtrate, and concentrating the filtrate at 70-80 ℃ to 1/3-1/4 of the original volume to obtain the traditional Chinese medicine mixture.

Typical case 1

In a certain woman, 28 years old, office clerks and offices, the working time is sitting, drinking water is little, the exercise amount is little, the waist is often sore and aching, the hospital examination shows that color ultrasonography shows that the calculi is 1.1-1.3cm, the calculi are shaken twice after illness, the lower abdominal pain still exists, the urethra is stabbing and the waist and the back are slightly sore and heavy, the symptoms are repeatedly attacked, the patient can see a doctor before the introduction of the patient, the patient can take the mixture for one month, the symptoms are relieved, the patient continues to take the mixture for 2 months, the calculi basically disappear after the color ultrasonography examination, and the patient can not relapse after the follow-up diagnosis.

Typical case 2

And after the mixture is introduced and taken for half a month, the symptoms are obviously improved, the pain is obviously relieved, other uncomfortable symptoms do not exist, and after the mixture is continuously taken for 1 month, the examination result is rechecked again to show that the calculus in the kidney of the patient disappears and the patient is completely cured.

Typical case 3

The Chinese medicinal composition is 55 years old, is over-tired for a long time, is soreness and pain in waist, is used for hospital visit, shows double kidney (multiple) calculus, right ureteral calculus, isolated kidney of left kidney and multiple calculus and obstruction, is introduced by people to take the Chinese medicinal composition, reduces symptoms of frequent micturition, urgent micturition and odynuria after two weeks, relieves discomfort in bladder area and the like, disappears after one month, rechecks urinary color Doppler ultrasound after two months, discharges calculus, and has no relapse after follow-up diagnosis.

Claims (3)

1. A traditional Chinese medicine mixture for treating calculus removal is characterized in that: the mixture is prepared from the following raw material medicines in parts by weight:

14-18 g of herba pyrrosiae, 18-22 g of fried chicken's gizzard-membrane, 10-14 g of longhairy antenoron herb, 8-12 g of dried rehmannia root, 10-14 g of cluster mallow seed, 4-8 g of akebia stem, 8-12 g of peach seed, 8-12 g of tuckahoe, 8-12 g of achyranthes root, 14-18 g of raw liquorice, 10-14 g of talcum, 10-14 g of lygodium japonicum, 8-12 g of rhizoma alismatis, 8-12 g of cogongrass rhizome, 4-8 g of scutellaria baicalensis, 4-8 g of combined spicebush root and 7-11 g of cortex moutan.

2. The traditional Chinese medicine mixture for treating calculus removal according to claim 1, which is characterized in that: the mixture is prepared from the following raw material medicines in parts by weight:

16 g of herba pyrrosiae, 20 g of fried chicken's gizzard-membrane, 12 g of longhairy antenoron herb, 10 g of dried rehmannia root, 12 g of cluster mallow seed, 6 g of akebia stem, 10 g of peach seed, 10 g of tuckahoe, 10 g of achyranthes root, 16 g of raw liquorice, 12 g of talcum, 12 g of climbing fern spore, 10 g of rhizoma alismatis, 10 g of lalang grass rhizome, 6 g of scutellaria baicalensis, 6 g of combined spicebush root and 9 g of cortex moutan.

3. A preparation method of a traditional Chinese medicine mixture for treating calculus removal is characterized by comprising the following steps: the method comprises the following steps:

(1) mixing the pyrrosia leaf, the fried chicken's gizzard-membrane, the longhairy antenoron herb, the dried rehmannia root, the cluster mallow fruit, the akebia stem, the peach kernel, the poria cocos, the achyranthes bidentata, the raw liquorice, the talc, the climbing fern spore, the rhizoma alismatis, the lalang grass rhizome, the scutellaria baicalensis, the combined spicebush root and the tree peony bark, soaking the mixture in 20-30 parts of water for 1 hour, decocting the mixture at 180-200 ℃ for 30-60 min, filtering decoction, adding 10-20 parts of water into filter residue, decocting the mixture at 180-200 ℃ for 30-60 min, filtering the decoction, and combining the two decoctions;

(2) and (2) carrying out reflux extraction on the decoction liquid combined in the step (1) twice with water at 100 ℃, each time for 3 hours, carrying out vacuum concentration on the extracting solution, adding absolute ethyl alcohol, carrying out overnight precipitation at 4-20 ℃, taking the filtrate, and concentrating the filtrate at 70-80 ℃ to 1/3-1/4 of the original volume to obtain the traditional Chinese medicine mixture.