CN105213609A - A kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof, this Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 22-30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 19-28, Herba Centellae 14-22, Herba Portulacae 16-22, Catechu 13-20, Rhizoma Chuanxiong 14-22, Radix Angelicae Sinensis 10-16, Herba Menthae 11-18, Radix Rhodiolae 9-17, Folium Ginkgo 5-12, Radix Sanguisorbae 7-14, Radix Rehmanniae 10-16 and Radix Glycyrrhizae 6-14.Chinese prescription of the present invention is reasonable, synergism is strong, there is effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the rotten poison of removing and granulation promoting skin, dredging blood vessel meridians while the rotten poison of removing, the own metabolism of skin can be accelerated, enable toxin and antibacterial discharge the open sore part fast, simultaneously further enhancing human body immunity power, strengthen the resistance to antibacterial, fungus, infect once again after avoiding wound healing.

Description

A kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof.

Background technology

Decubital ulcer has another name called pressure ulcer (pressure ulcer), is the normal phase pressurized of local organization, continuous ischemia, anoxia, malnutrition and cause local organization fester, downright bad, be one of clinical common complication.The traditional Chinese medical science is called " bed-sore ", is because prolonged illness QI and blood is lost greatly, long-term bed, local compression so that vim and vigour running not normal, meridians block, and are difficult caused by flourish skin, and as given treatment to not in time, meat rotten bone dew concurrent infection, causes septicemia time serious, cause death.

Compared with Chinese patent medicine, many application disinfectant or antibiotic when traditional doctor trained in Western medicine is changed dressings, although effectively can control antibacterial, but also inevitably inhibit the health regeneration of wound surface cell, thus causing wound healing slowly, protracted inflammation is not healed, and affects the live and work of patient.

The main principle for the treatment of by Chinese herbs decubital ulcer is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, promotes that slough is discharged, and accelerates granulation tissue growth, necrotic tissue cleaning is external, improve the microcirculation of wound surface surrounding tissue, increase regional flow, can promote that remaining epithelial cell tissues grows, putrefaction-removing granulation-promoting simultaneously, activate body endogenous debridement process, show as painless debridement, normal tissue has no side effect, and fills wound sinus tract and lacuna, prevents wound from subsiding, ease the pain, absorb wound exudate.

Chinese patent application 201510239732.0 discloses a kind of Chinese medicine ointment being used for the treatment of decubital ulcer, this ointment is obtained by following raw material: Cortex Phellodendri 10-12, Sanguis Draxonis 3-4, Radix Arnebiae (Radix Lithospermi) 2-4, Radix Astragali 8-10, Radix Angelicae Dahuricae 5-6, Rhizoma Atractylodis 2-4, Radix Angelicae Sinensis 8-10, Radix Codonopsis 4-5, Radix Ampelopsis 2-4, Olibanum (processed) 5-6, Myrrha 9-10, Rhizoma Chuanxiong 3-4, Radix Trichosanthis 2-4, Cornu Cervi Degelatinatum 6-7, Radix Paeoniae Alba 4-6, fry Squama Manis 3-4, fry Spina Gleditsiae 1-3, Caulis Sargentodoxae 6-8, Rhizoma Polygoni Cuspidati 4-5, Cortex Moutan 9-11, Folium Artemisiae Argyi 2-4, Rhizoma Coptidis (processed with wine) 4-5, Semen Strychni (processed) 8-10, succinum 2-4, Fructus Dracontomeli Duperreani leaf 2-4, and Herba Gelsemii Elegantis 1-3.This ointment has certain curative effect in treatment decubital ulcer, but this Drug therapy decubital ulcer is long for the course for the treatment of, and Chinese prescription is complicated, and treatment cost is high.

Summary of the invention

There is to solve in prior art the medicine for the treatment of decubital ulcer the shortcoming that healing is slow, treatment time is long and treatment cost is high, the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of decubital ulcer, to solve the problem.Meanwhile, the present invention also provides the preparation technology of this Chinese medicine composition.

Chinese medicine composition of the present invention comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 22-30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 19-28, Herba Centellae 14-22, Herba Portulacae 16-22, Catechu 13-20, Rhizoma Chuanxiong 14-22, Radix Angelicae Sinensis 10-16, Herba Menthae 11-18, Radix Rhodiolae 9-17, Folium Ginkgo 5-12, Radix Sanguisorbae 7-14, Radix Rehmanniae 10-16 and Radix Glycyrrhizae 6-14.

Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 22, Folium eucalypti globueli (Eucalyptus globulus Labill.) 19, Herba Centellae 14, Herba Portulacae 16, Catechu 13, Rhizoma Chuanxiong 14, Radix Angelicae Sinensis 10, Herba Menthae 11, Radix Rhodiolae 9, Folium Ginkgo 5, Radix Sanguisorbae 7, Radix Rehmanniae 10 and Radix Glycyrrhizae 6.

Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 28, Herba Centellae 22, Herba Portulacae 22, Catechu 20, Rhizoma Chuanxiong 22, Radix Angelicae Sinensis 16, Herba Menthae 18, Radix Rhodiolae 17, Folium Ginkgo 12, Radix Sanguisorbae 14, Radix Rehmanniae 16 and Radix Glycyrrhizae 14.

Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 26, Folium eucalypti globueli (Eucalyptus globulus Labill.) 24, Herba Centellae 17, Herba Portulacae 18, Catechu 15, Rhizoma Chuanxiong 18, Radix Angelicae Sinensis 12, Herba Menthae 14, Radix Rhodiolae 13, Folium Ginkgo 9, Radix Sanguisorbae 11, Radix Rehmanniae 12 and Radix Glycyrrhizae 10.

In addition, present invention also offers a kind of preparation method for the treatment of the Chinese medicine composition of decubital ulcer, comprise the following steps:

S1: get Herba Portulacae, wash away impurity, crushed after being dried, cross 60-80 mesh sieve, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 240-300W, and Extracting temperature is 40-60 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;

S2: get Folium Artemisiae Argyi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae, Catechu, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Menthae, Radix Rhodiolae, Folium Ginkgo, Radix Sanguisorbae, Radix Rehmanniae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge described Herba Portulacae medicinal residues, add the water of coarse powder total amount 15-20 times amount, soak 20-30 minute, reflux, extract, 2-3 time, each 1-3 hour, filter, merging filtrate, the extractum that relative density is 1.10-1.20 is surveyed at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter and retain filtering residue, obtain filtrate A,

S3: the filtering residue obtained in S2 slowly being added while stirring its weight 4-6 times amount volume fraction is the ethanol of 40-60%, 4 DEG C of standing 3-5 hour, filters, obtains liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;

S4: merge described filtrate A, liquor B and cleaning mixture, surveys extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;

S5: extractum obtained in described Herba portulacae extract and S4 is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, is pulverized by dry extract after drying, crosses 100-200 mesh sieve, add adjuvant, make preparation.

Chinese medicine composition of the present invention preferably makes powder, ointment or gel, is convenient to patient and uses.

In Chinese medicine composition of the present invention component used source, nature and flavor, return through and effect:

Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort; Bitter in the mouth, warm in nature; Return liver,spleen,kidney warp; Dispersing cold for relieving pain, warming the meridian for stopping bleeding.

Folium eucalypti globueli (Eucalyptus globulus Labill.): this product is the leaf for myrtle Eucalyptus globulus Labill; Bitter in the mouth, warm in nature; Return lung, stomach, spleen, Liver Channel; Dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, phlegm-eliminiating and qi-regulating, killing parasites for relieving itching.

Herba Centellae: this product is the dry herb of samphire Herba Centellae; Bitter in the mouth, cold in nature; Return liver,spleen,kidney warp; Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.

Herba Portulacae: this product is the dry aerial parts of portulacaceous plant Herba Portulacae; Sour in the mouth, cold in nature; Return liver, large intestine channel; Heat-clearing and toxic substances removing, cooling blood for hemostasis.

Catechu: this product is the powdered extract that the branch of leguminous plant catechu or the branch and leaf of Maguireothamnus speciosus Uncaria gambier Roxb. are decocted juice and concentrated; Bitter and puckery flavor, cool in nature; Enter the heart, lung; Heat clearing away, reduce phlegm, stop blooding, help digestion, granulation promoting, analgesic therapy.

Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.

Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, warm in nature; Return liver, the heart, spleen channel; Enrich blood invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.

Herba Menthae: property is pungent, cool, returns lung, Liver Channel.Dispelling wind-heat, refresh oneself, rash; For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.

Radix Rhodiolae: this product is the dry Herb of plant Radix Rhodiolae; Cold, sweet, puckery; Lung meridian; Have QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae nourished heart, effect of hemostasis with astringents, dissipating blood stasis for subsidence of swelling.Cure mainly deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, spitting of blood, leucorrhea diarrhoea, traumatic injury etc.

Folium Ginkgo: this product is the dried leaves of Ginkgoaceae plant Ginkgo biloba; Sweet, bitter, puckery, flat; GUIXIN, lung meridian; Blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringes the lung and relievings asthma, and changes turbid blood fat reducing.

Radix Sanguisorbae: this product is the dry root of rosaceous plant Radix Sanguisorbae or the Radix Sanguisorbae that comes into leaves; Bitter in the mouth, cold nature; Enter liver, large intestine channel; Cooling blood for hemostasis, removing toxic substances sore.

Radix Rehmanniae: the fresh rhizome that this product is scrophulariaceae rehmannia glutinosa plant; Sweet-bitter flavor, cold nature; Enter the heart, liver, kidney channel; Heat clearing away, removing heat from blood, to promote the production of body fluid.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

The prescription analysis of Chinese prescription of the present invention:

Chinese prescription of the present invention is with Folium Artemisiae Argyi, Folium eucalypti globueli (Eucalyptus globulus Labill.) for monarch drug, dispersing cold for relieving pain, dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing; With Herba Centellae, Herba Portulacae, Catechu, Rhizoma Chuanxiong for ministerial drug, removing toxic substances and promoting subsidence of swelling, granulation promoting, wind-expelling pain-stopping; With Radix Angelicae Sinensis, Herba Menthae, Radix Rhodiolae, Folium Ginkgo, Radix Sanguisorbae, Radix Rehmanniae for adjuvant drug, enrich blood invigorate blood circulation, the pain relieving that helps digestion, removing toxic substances sore; With Radix Glycyrrhizae for making medicine, making all medicine coordinated, complementing each other, jointly reach the effects such as removing toxic substances and promoting subsidence of swelling, blood circulation promoting and blood stasis dispelling, granulation promoting skin, have very significant therapeutic effect to decubital ulcer.

Compared with prior art, Chinese medicine composition of the present invention has effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the rotten poison of removing and granulation promoting skin in treatment decubital ulcer, dredging blood vessel meridians while the rotten poison of removing, the own metabolism of skin can be accelerated, toxin and antibacterial is enable to discharge the open sore part fast, further enhancing human body immunity power, strengthens the resistance to antibacterial, fungus, infects once again after avoiding wound healing simultaneously.And preparation method provided by the invention is simple and easy to do, applied widely, toxic and side effects is little, be easy to apply.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

Embodiment 1

The embodiment of the present invention 1 Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 22, Folium eucalypti globueli (Eucalyptus globulus Labill.) 19, Herba Centellae 14, Herba Portulacae 16, Catechu 13, Rhizoma Chuanxiong 14, Radix Angelicae Sinensis 10, Herba Menthae 11, Radix Rhodiolae 9, Folium Ginkgo 5, Radix Sanguisorbae 7, Radix Rehmanniae 10 and Radix Glycyrrhizae 6.

Preparation method:

S1: get Herba Portulacae, wash away impurity, crushed after being dried, cross 80 mesh sieves, adding medical material gross weight 9 times amount volume fraction is the ethanol of 70%, microwave extraction 10 minutes, microwave power is 280W, and Extracting temperature is 50 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;

S2: get Folium Artemisiae Argyi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae, Catechu, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Menthae, Radix Rhodiolae, Folium Ginkgo, Radix Sanguisorbae, Radix Rehmanniae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge described Herba Portulacae medicinal residues, add the water of coarse powder total amount 18 times amount, soak 25 minutes, reflux, extract, 3 times, each 1 hour, filter, merging filtrate, surveys the extractum that relative density is 1.20 at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 50%, 4 DEG C leave standstill 24 hours, filter and retain filtering residue, obtaining filtrate A;

S3: the filtering residue obtained in S2 slowly being added while stirring its weight 5 times amount volume fraction is the ethanol of 50%, 4 DEG C leave standstill 4 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 3 times of 50% again, collects and merges cleaning mixture;

S4: merge described filtrate A, liquor B and cleaning mixture, surveys extractum that relative density be 1.20 under being evaporated to 60 DEG C of conditions after mixing;

S5: extractum obtained in described Herba portulacae extract and S4 is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, and charging rate is 12L/h, and material strip transfer rate is 28cm/min, after drying, dry extract is pulverized, cross 200 mesh sieves, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, S4 gained Chinese medical concrete is made ointment, and amounting to crude drug content is 7.53g crude drug/pipe.

Embodiment 2

The embodiment of the present invention 2 Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 28, Herba Centellae 22, Herba Portulacae 22, Catechu 20, Rhizoma Chuanxiong 22, Radix Angelicae Sinensis 16, Herba Menthae 18, Radix Rhodiolae 17, Folium Ginkgo 12, Radix Sanguisorbae 14, Radix Rehmanniae 16 and Radix Glycyrrhizae 14.

Preparation method is as identical in embodiment 1, makes gel.

Embodiment 3

The embodiment of the present invention 3 Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 26, Folium eucalypti globueli (Eucalyptus globulus Labill.) 24, Herba Centellae 17, Herba Portulacae 18, Catechu 15, Rhizoma Chuanxiong 18, Radix Angelicae Sinensis 12, Herba Menthae 14, Radix Rhodiolae 13, Folium Ginkgo 9, Radix Sanguisorbae 11, Radix Rehmanniae 12 and Radix Glycyrrhizae 10.

Preparation method is as identical in embodiment 1, makes powder.

Pharmacodynamic experiment

One, traditional Chinese medicine composition for treating Cavia porcellus decubital ulcer model test of the present invention

1. test material:

1.1, experimental animal: male guinea pig, body weight (280 ± 20) g, is provided by Nanjing Medical University's animal experimental center.

1.2, test drug: the ointment for the treatment of decubital ulcer prepared by embodiment 3, MAYINGLONG MUSK HEMORRHOID UNGUENTUM, the accurate word of traditional Chinese medicines is: Z42021920, is purchased from Mayinglong Pharmaceutical Group Co., Ltd.

2. set up animal model: 60 Cavia porcelluss to be anaesthetized, skin degerming, fix with ventricumbent position, cutting near the left side of back spinal column the openning that is being about 3cm, implant through autoclaved 4.0cmx2.5cmx0.05cm stainless-steel sheet, sew up the incision, and bind up a wound, fix with binder.The postoperative single cage of Cavia porcellus is fed, and observes ld.4.0cmx2.5cmx1.0cm Magnet compressing wound surface (5h/d) after 24h, rest 12h circulates 1 time, total pressing time 10h, the formation area of record decubital ulcer and calibration grade.Divide cage separately by animal, feed and management condition consistent.

3. test method: Cavia porcellus decubital ulcer model forms latter 2nd day, Cavia porcellus is divided into 3 groups at random, is respectively normal group, positive controls and embodiment 3 groups, each group process is as follows:

Normal group: after cleaning a wound with 0.9% sodium chloride, does not do other process;

Positive controls: after cleaning a wound with 0.9% sodium chloride, MAYINGLONG MUSK HEMORRHOID UNGUENTUM is applied to wound;

Embodiment 3 groups: after cleaning a wound with 0.9% sodium chloride, the ointment for the treatment of decubital ulcer embodiment 3 prepared is applied to wound;

Aforesaid operations smears 1 time every day, and medication judged effect after 14 days.

4. observation index:

According to decubital ulcer staging scale, cure as wound disappears, epidermis heals; Transfer well wound contraction 80% to, granulation is fresh, grows, edema extinction, and sepage is few; Invalid is wound contraction 50%, granulation undergrowth or have purulence sepage.

5. result of the test

Treat patients with decubitus effect and healing days of table 1 Cavia porcellus compares

Note: compare with normal group, ^{△ △}p < 0.01.

As shown in Table 1, the ointment of the treatment decubital ulcer using the embodiment of the present invention 3 to prepare heals substantially at about 9 days wounds, and cure rate reaches 75%, and inefficiency is 0, proves that bedsore ointment prepared by the present invention has significant therapeutic effect to decubital ulcer.

Two, the clinical trial of Chinese medicine composition of the present invention

1. clinical study

Choose the clinical volunteer patients that 120 examples suffer from decubital ulcer, wherein man 70 example, female 50 example, age 48-88 year, patient skin ulcer face diameter 1 ~ 30cm before the treatment, ulcerative stage 78 example, the deep ulcer phase 42 example; 120 routine patients are divided into 2 groups at random, are respectively treatment group and matched group, often organize 60 people.Two groups of Genders, age, severity extent and clinical manifestations, through statistical procedures no significant difference, have comparability.

2. trial drug and test method

Treatment group: the ointment smearing treatment decubital ulcer prepared by the embodiment of the present invention 3, changes dressings 1 every day, each 0.52-1.04g, Continuous Observation 14 days.

Matched group: wound surface surrounding skin 75% alcohol disinfecting, wound surface 0.1% bromo geramine cleans, and wipes out slough as far as possible, then applies with Oleum Radix Arnebiae (Oleum Radix Lithospermi) gauze, and cover wrapping with sterile gauze, other are identical with observation group.

3. criterion of therapeutical effect

" the Chinese medical disease Standardization of diagnosis and curative effect " implemented with reference to the State Administration of Traditional Chinese Medicines is also drafted in conjunction with the concrete condition of this research.

Recovery from illness: wound healing, without inflammatory exudation, skin ulcer reduction of area is little, has new granulation tissue to generate and epithelial tissue covering;

Effective: traumatic infection controls, and the little >80% of skin ulcer reduction of area, have granulation tissue to generate, but wound does not heal completely;

Invalid: before and after treatment, wound contrast is not improved, and have no granulation growth, wound surface reduces <40%.

4. result of the test

Table 2 liang group Clinical efficacy comparison (%)

Group	N	Recovery from illness (rate)	Effectively (rate)	Invalid (rate)	Total effective rate (%)
						Treatment group	60	45(75.0％)	12(20.0％)	3(5.0％)	95.0％
Matched group	60	35(58.3％)	15(25％)	10(16.7％)	83.3％

5. conclusion (of pressure testing)

Result of the test shows, and the ointment for the treatment of decubital ulcer prepared by the present invention has significant effect in treatment decubital ulcer, and cure rate reaches 75%, and total effective rate reaches 95%, is obviously better than the effect of matched group.Clinical test results shows, the ointment that the present invention treats decubital ulcer has significant technical advantage in treatment decubital ulcer, can apply as clinical treatment decubital ulcer medicine.

Claims (6)

1. treat a Chinese medicine composition for decubital ulcer, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 22-30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 19-28, Herba Centellae 14-22, Herba Portulacae 16-22, Catechu 13-20, Rhizoma Chuanxiong 14-22, Radix Angelicae Sinensis 10-16, Herba Menthae 11-18, Radix Rhodiolae 9-17, Folium Ginkgo 5-12, Radix Sanguisorbae 7-14, Radix Rehmanniae 10-16 and Radix Glycyrrhizae 6-14.

2. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 22, Folium eucalypti globueli (Eucalyptus globulus Labill.) 19, Herba Centellae 14, Herba Portulacae 16, Catechu 13, Rhizoma Chuanxiong 14, Radix Angelicae Sinensis 10, Herba Menthae 11, Radix Rhodiolae 9, Folium Ginkgo 5, Radix Sanguisorbae 7, Radix Rehmanniae 10 and Radix Glycyrrhizae 6.

3. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 28, Herba Centellae 22, Herba Portulacae 22, Catechu 20, Rhizoma Chuanxiong 22, Radix Angelicae Sinensis 16, Herba Menthae 18, Radix Rhodiolae 17, Folium Ginkgo 12, Radix Sanguisorbae 14, Radix Rehmanniae 16 and Radix Glycyrrhizae 14.

4. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:

Folium Artemisiae Argyi 26, Folium eucalypti globueli (Eucalyptus globulus Labill.) 24, Herba Centellae 17, Herba Portulacae 18, Catechu 15, Rhizoma Chuanxiong 18, Radix Angelicae Sinensis 12, Herba Menthae 14, Radix Rhodiolae 13, Folium Ginkgo 9, Radix Sanguisorbae 11, Radix Rehmanniae 12 and Radix Glycyrrhizae 10.

5. the Chinese medicine composition of the treatment decubital ulcer as described in as arbitrary in claim 1-4, it is characterized in that, described Chinese medicine composition is made into powder, ointment or gel.

6. the preparation method of the Chinese medicine composition of the treatment decubital ulcer as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises following step:

S1: get Herba Portulacae, wash away impurity, crushed after being dried, cross 60-80 mesh sieve, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 240-300W, and Extracting temperature is 40-60 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;

S2: get Folium Artemisiae Argyi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae, Catechu, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Menthae, Radix Rhodiolae, Folium Ginkgo, Radix Sanguisorbae, Radix Rehmanniae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge described Herba Portulacae medicinal residues, add the water of coarse powder total amount 15-20 times amount, soak 20-30 minute, reflux, extract, 2-3 time, each 1-3 hour, filter, merging filtrate, the extractum that relative density is 1.10-1.20 is surveyed at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter and retain filtering residue, obtain filtrate A,

S3: the filtering residue obtained in S2 slowly being added while stirring its weight 4-6 times amount volume fraction is the ethanol of 40-60%, 4 DEG C of standing 3-5 hour, filters, obtains liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;

S4: merge described filtrate A, liquor B and cleaning mixture, surveys extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;

S5: extractum obtained in described Herba portulacae extract and S4 is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, is pulverized by dry extract after drying, crosses 100-200 mesh sieve, add adjuvant, make preparation.