CN113633597A

CN113633597A - Shampoo with plant fermentation extracted components and preparation method thereof

Info

Publication number: CN113633597A
Application number: CN202110347355.8A
Authority: CN
Inventors: 李圣国; 杨子锋; 杨子荣
Original assignee: Guangzhou Baiaishen Biotechnology Co ltd
Current assignee: Guangzhou Baiaishen Biotechnology Co ltd
Priority date: 2021-03-31
Filing date: 2021-03-31
Publication date: 2021-11-12

Abstract

The invention discloses a plant fermentation extract component shampoo and a preparation method thereof, and the shampoo comprises the following components in parts by weight: 20-30 parts of natural plant extract component compound, 65-80 parts of shampoo matrix, 0.05-0.1 part of preservative and 0.02-0.05 part of essence. Through the specific proportioning of the components, the prepared shampoo has strong cleaning power and no stimulation, can promote scalp blood circulation, effectively terminate abnormal alopecia and promote hair regeneration, can balance scalp grease, improve scalp environment, inhibit bacterial growth, strengthen hair roots, improve hair toughness and fundamentally condition scalp health, thereby achieving the purpose of improving and preventing seborrheic alopecia.

Description

Shampoo with plant fermentation extracted components and preparation method thereof

Technical Field

The invention relates to the field of daily chemicals, and particularly designs plant fermentation extract component shampoo and a preparation method thereof.

Background

The alopecia includes alopecia areata, androgenetic alopecia, psychogenic alopecia, etc. Among them, seborrheic alopecia and psychogenic alopecia are the most common. Androgenetic alopecia, also known as seborrheic alopecia, is mostly seen in young and strong males, is usually manifested by initial forehead and bilateral baldness, gradually and symmetrically extending towards the top of the head, thin and thin hair, spontaneous pruritus, and exuberant scalp sebum secretion, and is mainly manifested by increased number of hair follicles in the resting stage, decreased number of hair follicles in the terminal stage of growth, obvious miniaturization of hair follicles, shortened growth period, and inflammation and fibrosis in the terminal stage of the course. The capillaries of the dermis and the subcutaneous tissue almost completely disappear, the platelet aggregation is increased, and the blood viscosity is increased. Although seborrheic alopecia has no subjective symptoms, the psychological influence on a person suffering from alopecia is large, and along with the improvement of living standard, people pay more attention to the treatment of alopecia.

At present, the medicines and the methods applied to clinic can not realize effective treatment, and have the defects of side effects of different degrees, easy relapse after medicine withdrawal and the like. The natural plant extract components of traditional Chinese medicine, Chinese herbal medicine and the like have the advantages of unique curative effect, focusing on internal and external regulation, less side effect and the like. However, because the pharmacology and usage of traditional Chinese herbal medicines are generally referred to based on experience, the dosage and principle cannot be completely accurate and popularized, and more comprehensive symptomatic medication cannot be achieved according to the principle aiming at the etiology.

Disclosure of Invention

In order to solve the above problems, it is an object of the present invention to provide a plant fermentation extract shampoo which can effectively terminate alopecia and promote hair regrowth, and has an excellent effect on seborrheic alopecia, and a preparation method thereof.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows:

the invention provides a plant fermentation extract component shampoo which comprises the following components in parts by weight: 20-30 parts of natural plant extract component compound, 65-80 parts of shampoo matrix, 0.05-0.1 part of preservative and 0.02-0.05 part of essence.

As a preferable technical scheme, the natural plant extract component compound comprises cacumen biotae extract, camellia seed cake extract, ginger root extract, ginseng root extract, fructus forsythiae extract, polygonum multiflorum root extract, caffeine, preservative, humectant and water.

As a preferred technical scheme, the natural plant extract component compound comprises, by weight, 3-5 parts of cacumen biotae extract, 3-5 parts of camellia seed cake extract, 3-5 parts of ginger root extract, 2-4 parts of ginseng root extract, 2-4 parts of fructus forsythiae extract, 2-4 parts of polygonum multiflorum root extract, 0.03-0.05 part of caffeine, 3-6 parts of humectant, 0.3-0.6 part of preservative and the balance of water.

According to a preferable technical scheme, the shampoo matrix comprises, by weight, 6.5-12 parts of a surfactant, 0.3-1.0 part of a thickening agent, 3-5 parts of a softener, 14-22 parts of a foaming agent and 25-48 parts of water.

As a preferable technical scheme, the surfactant comprises 2-5 parts of cocamidopropyl betaine, 4-6 parts of sodium lauroyl sarcosinate and 0.5-1.0 part of cocamide DEA.

As a preferable technical scheme, the thickening agent comprises 0.1-0.5 part of acrylate/C10-30 alkanol acrylate cross-linked polymer and 0.2-0.5 part of guar gum hydroxypropyl trimethyl ammonium chloride.

As a preferred technical solution, the softener comprises polydimethylsiloxane.

As a preferable technical scheme, the foaming agent comprises 2-4 parts of ammonium lauryl sulfate and 12-18 parts of sodium laureth sulfate.

As a preferable technical scheme, the preservative comprises methylisothiazolinone and phenoxyethanol, wherein the weight ratio of methylisothiazolinone to phenoxyethanol is 10: 1.

the invention also provides a preparation method of the plant fermentation extract component shampoo, which comprises the following steps:

(1) preparing a natural plant extract component compound:

sequentially adding folium Platycladi extract, herba Camelliae Japonicae cake extract, rhizoma Zingiberis recens extract, Ginseng radix extract, fructus forsythiae extract, and Polygoni Multiflori radix extract into a reaction kettle, stirring, and adding caffeine, antiseptic, humectant, and water; continuously stirring until the mixture is uniform to obtain a natural extraction component compound;

(2) preparing the shampoo:

and (2) adding the natural extraction component compound prepared in the step (1), the preservative and the essence into the shampoo matrix, continuously stirring until the mixture is uniform, and then carrying out aseptic filling to obtain the shampoo.

Has the advantages that:

(1) the shampoo prepared from the cacumen biotae extract, the camellia seed cake extract, the ginger root extract, the ginseng root extract, the fructus forsythiae extract and the polygonum multiflorum root extract in a specific ratio can effectively balance scalp grease, improve scalp environment, repair damaged hair and hair scales, strengthen hair roots, fundamentally condition scalp health, and has a better anti-hair loss effect;

(2) the plant extract and the caffeine in a specific ratio are matched for use, so that a synergistic effect can be generated, the expression of insulin growth factor in hair follicles can be well enhanced, and the proliferation of keratinocytes is promoted; simultaneously effectively inhibiting the generation of dihydrotestosterone hormone, promoting scalp blood circulation and improving alopecia symptoms; can also activate the metabolism of cells in the hair washing process and prolong the growth cycle of the cells;

(3) the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and guar gum hydroxypropyl trimethyl ammonium chloride are proportioned to form a three-dimensional network structure, so that a suspension stabilizing system is played, and a synergistic effect can be generated by adding cocoamide DEA in a specific proportion, so that water and oil are uniformly dispersed in a solution, the product keeps a dispersion form for a long time to avoid coagulation, the storage stability of the product is facilitated, and meanwhile, a layer of film can be formed to lock the water of the product, so that the efficacy of the product is effectively maintained;

(4) the surfactant used in the invention is compounded by cocoamidopropyl betaine, sodium lauroyl sarcosinate and cocoamidoDEA in a specific ratio, and is cooperated with foaming agents of ammonium lauryl sulfate and sodium lauryl polyether sulfate, so that the product has strong cleaning power, small stimulation, quick foaming, rich foam, easy cleaning and no residue;

(5) the formula is perfected through clinical tests and animal experiments, and the effectiveness and the safety of the formula are verified.

Detailed Description

The invention will be further understood by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. To the extent that a definition of a particular term disclosed in the prior art is inconsistent with any definition provided in the present disclosure, the definition of the term provided in the present disclosure controls.

As used herein, a feature that does not define a singular or plural form is also intended to include a plural form of the feature unless the context clearly indicates otherwise. It will be further understood that the term "prepared from …," as used herein, is synonymous with "comprising," including, "comprising," "having," "including," and/or "containing," when used in this specification means that the recited composition, step, method, article, or device is present, but does not preclude the presence or addition of one or more other compositions, steps, methods, articles, or devices. Furthermore, the use of "preferred," "preferably," "more preferred," etc., when describing embodiments of the present invention, is meant to refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. In addition, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

In order to achieve the purpose, the invention provides a plant fermentation extract component shampoo which comprises the following components in parts by weight: 20-30 parts of natural plant extract component compound, 65-80 parts of shampoo matrix, 0.05-0.1 part of preservative and 0.02-0.05 part of essence.

In some preferred embodiments, the natural plant extract component complex comprises cacumen Platycladi extract, camellia seed cake extract, ginger root extract, ginseng root extract, forsythia fruit extract, polygonum multiflorum root extract, caffeine, preservatives, moisturizers, water.

The preparation method of the cacumen biotae extract comprises the following specific steps:

taking fresh cacumen biotae, cleaning, drying, crushing, sieving with a 40-mesh sieve, adding a 10-fold amount of a mixed solution of deionized water and ethanol into the crushed cacumen biotae, and soaking for 8-10 hours at 25-30 ℃, wherein the mass concentration of the ethanol is 98%, and the volume ratio of the deionized water to the 98% ethanol is 40: 60, placing the mixture of the cacumen biotae and the soak solution in an ultrasonic extractor for ultrasonic extraction for 1.5-2.5 hours, wherein the pressure is normal pressure, the temperature is 60-80 ℃, and the ultrasonic frequency is 200-400 HZ; after ultrasonic extraction, taking supernatant to obtain cacumen biotae extract, then carrying out centrifugal filtration on the cacumen biotae extract, collecting filtrate and recovering ethanol, and finally obtaining filtrate which is the cacumen biotae extract;

the preparation method of the camellia seed cake extract, the ginger root extract, the ginseng root extract, the forsythia fruit extract and the polygonum multiflorum root extract refers to the preparation method of the cacumen biotae extract, and the fresh cacumen biotae is replaced by the fresh camellia seed cake, the fresh ginger root, the fresh ginseng root, the fresh forsythia fruit and the fresh polygonum multiflorum root correspondingly to obtain the corresponding extracts.

In some preferred embodiments, the natural plant extract component compound comprises, by weight, 3-5 parts of cacumen biotae extract, 3-5 parts of camellia seed cake extract, 3-5 parts of ginger root extract, 2-4 parts of ginseng root extract, 2-4 parts of fructus forsythiae extract, 2-4 parts of polygonum multiflorum root extract, 0.03-0.05 part of caffeine, 3-6 parts of humectant, 0.3-0.6 part of preservative, and the balance of water.

The applicant finds that when 3-5 parts of cacumen biotae extract, 3-5 parts of camellia seed cake extract, 3-5 parts of ginger root extract, 2-4 parts of ginseng root extract, 2-4 parts of fructus forsythiae extract and 2-4 parts of polygonum multiflorum root extract are added, the weight ratio of the cacumen biotae extract to the camellia seed cake extract to the ginger root extract is 1: 1: 1, the weight ratio of the ginseng root extract, the forsythia suspensa fruit extract and the polygonum multiflorum root extract is 1: 1: the shampoo prepared in the 1 hour can effectively balance scalp grease, improve scalp environment, repair damaged hair and hair scales, strengthen hair roots and fundamentally condition scalp health, so that a better anti-hair loss effect can be achieved, and the specific reason is presumed as follows: the camellia seed cake extract has good dispersibility and permeability, can be attached to the hair to fill the damaged part of hair scales, and can form a protective layer to keep the moisture content in the hair stable and enhance the toughness of the hair; the gingerol and shorene oil contained in the ginger root extract can normalize the blood circulation of head skin, promote scalp metabolism and activate hair follicle tissues; the folium Platycladi extract has effects in cooling blood, stopping bleeding, promoting hair growth, and blackening hair; when the weight ratio of the three components is 1: 1: 1, it has more obvious effect, and can effectively prevent alopecia and canities, stimulate new hair growth, inhibit scalp itch, and strengthen hairy root. The ginseng root extract and the polygonum multiflorum root extract can provide sufficient nutrition for scalp, expand the capillary vessels of the head, nourish the hair, improve the toughness of the hair, reduce alopecia and broken hair, and have a protection effect on damaged hair.

In addition, the applicant also finds that the plant extract and the caffeine in a specific ratio are matched for use, so that a synergistic effect can be generated, the expression of insulin growth factor-in hair follicles can be well enhanced, the proliferation of keratinocytes is promoted, the generation of dihydrotestosterone hormone can be effectively inhibited, the blood circulation of scalp is promoted, the alopecia symptom is improved, the hair follicle stem cells are taken as targets, the expression of various growth factors is induced, the proliferation and differentiation of the hair follicle stem cells are further regulated, the blood nutrient supply of the scalp is improved, the hair follicle in a dormant period is stimulated to return to an active growth period, and the abnormal hair loss can be effectively terminated and the hair regeneration is promoted; can also induce the expression of beta-catenin in hair follicle cells, activate a classical Wnt signal transduction pathway and regulate the secretion of Wnt protein, thereby regulating the proliferation of hair follicle stem cells, inducing the hair follicle stem cells to differentiate into hair follicles and promoting the growth of the hair follicles; can promote hair follicle cells to secrete hepatocyte growth factor, thereby controlling the growth of hair papilla in the hair follicle cells, inducing the formation of blood vessels around the hair follicle and ensuring the nutrition supply of hair roots; the shampoo is matched with the shampoo, so that the scalp can be cleaned and the hair can be nursed, meanwhile, the scalp skin can be maintained, and the effects of real washing and caring, synergistic effect and hair loss prevention are achieved.

In some preferred embodiments, the shampoo matrix comprises 6.5-12 parts by weight of surfactant, 0.3-1.0 part by weight of thickener, 3-5 parts by weight of softener, 14-22 parts by weight of foaming agent and 25-48 parts by weight of water.

The preparation method of the shampoo matrix comprises the following specific steps: and mixing the weighed surfactant, the thickener, the softener, the foaming agent and water at room temperature, and uniformly stirring at the rotating speed of 600-800 r/min to obtain the shampoo matrix.

In some preferred embodiments, the surfactant includes 2 to 5 parts of cocamidopropyl betaine, 4 to 6 parts of sodium lauroyl sarcosinate, and 0.5 to 1.0 part of cocamide DEA.

Cocamidopropyl betaine CAS number: 61789-40-0, is a kind of amphoteric ion surface active agent, has good stability under acidic and alkaline conditions, small irritation, easy water solubility, stable acid and alkali, more foam, strong detergency, and good thickening property, softness, bactericidal property, antistatic property and hard water resistance.

Sodium lauroyl sarcosinate, CAS No.: 137-16-6, is a surfactant, has mild performance, no stimulation, no skin dryness, characteristics of washing, permeation, emulsification, solubilization and the like, excellent foaming performance, antibacterial and bactericidal performance, mildew resistance, corrosion resistance and antistatic capacity, and fine foam.

Cocamide DEA, CAS number: 68603-42-9 is a nonionic surfactant, no cloud point, good solubility in water, low irritation, and hard water resistance.

In some preferred embodiments, the thickener comprises 0.1 to 0.5 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer and 0.2 to 0.5 parts of guar hydroxypropyltrimonium chloride.

In some preferred embodiments, the acrylate/C10-30 alkanol acrylate crosspolymer is commercially available, including, but not limited to, the acrylate/C10-30 alkanol acrylate crosspolymer, available from Beijing Huameili Biochemical Co., Ltd.

Guar hydroxypropyltrimethylammonium chloride, CAS No.: 65497-29-2, a water soluble high molecular polymer, is prepared by reacting natural guar gum with water-loss condensed glyceryl ether trimethyl ammonium chloride, and is compounded with acrylic ester/C10-30 alkanol acrylate crosslinked polymer to serve as thickener.

In addition, the applicant finds that the suspension stabilizing system can be achieved by adopting 0.1-0.5 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 0.2-0.5 part of guar gum hydroxypropyl trimethyl ammonium chloride in a ratio, and can generate a synergistic effect with 0.5-1.0 part of cocamide DEA to promote water and oil to be uniformly dispersed in a solution, so that the product keeps a dispersion state for a long time to avoid coagulation, the storage stability of the product is facilitated, a layer of film can be formed at the same time, the water of the product is locked, and the efficacy of the product is effectively maintained.

In some preferred embodiments, the softener comprises polydimethylsiloxane, which is commercially available, including, but not limited to, from Tianjin Wantai silicon technologies, Inc.

In some preferred embodiments, the foaming agent comprises 2-4 parts of ammonium lauryl sulfate and 12-18 parts of sodium laureth sulfate.

Ammonium lauryl sulfate, CAS No.: 68955-19-1, belonging to a powerful detergent ingredient, having a strong cleaning power and a foaming function, is used as a foaming agent in the present invention.

Sodium laureth sulfate, CAS No.: 9004-82-4, has washing, emulsifying, and dispersing effects, excellent biodegradability and low temperature performance, high activity, and no influence of water hardness.

In some preferred embodiments, the humectant is a C3-C5 alcohol containing two hydroxyl groups, and is further preferably propylene glycol.

In some preferred embodiments, the preservative comprises methylisothiazolinone and phenoxyethanol in a weight ratio of 10: 1.

methylisothiazolinone, CAS No.: 2682-20-4, a preservative, inhibits the growth of bacteria, fungi and molds, has broad spectrum bactericidal efficacy at low concentrations, and is therefore widely used in cosmetics and personal care products as a highly effective preservative.

Phenoxyethanol, CAS No.: 122-99-6, is commonly used as a preservative in cosmetics, and has high efficiency, broad spectrum, low toxicity and no anaphylactic irritation.

In some preferred embodiments, the caffeine is commercially available, including but not limited to, caffeine available from Chiloeia (Shanghai) chemical industries, Inc.

In some preferred embodiments, the perfume may be obtained by commercial purchase, without limitation to the manufacturer and type of purchase.

(1) preparing a natural plant extract component compound:

sequentially adding the cacumen biotae extract, the camellia seed cake extract, the ginger root extract, the ginseng root extract, the forsythia fruit extract and the polygonum multiflorum root extract into a reaction kettle, uniformly stirring at the rotating speed of 600-800 r/min, and adding caffeine, a preservative, a humectant and water; continuously stirring at the rotating speed of 600-800 r/min until the mixture is uniform to obtain a natural extraction component compound;

(2) preparing the shampoo:

and (2) adding the natural extraction component compound prepared in the step (1), the preservative and the essence into the shampoo matrix, continuously stirring at the rotating speed of 800-1000 r/min until the mixture is uniform, and then carrying out aseptic filling to obtain the shampoo.

Examples

In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the starting materials used are all commercially available, unless otherwise specified.

Example 1

Firstly, preparing a plant extract, wherein the preparation method of the cacumen biotae extract comprises the following specific steps:

cleaning, drying and crushing fresh cacumen biotae, sieving with a 40-mesh sieve, adding a 10-time amount of a mixed solution of deionized water and ethanol into the crushed cacumen biotae, and soaking for 10 hours at 25 ℃, wherein the mass concentration of the ethanol is 98%, and the volume ratio of the deionized water to the 98% ethanol is 40: 60, placing the mixture of the cacumen biotae and the soak solution in an ultrasonic extractor for ultrasonic extraction for 2 hours, wherein the pressure is normal pressure, the temperature is 70 ℃, and the ultrasonic frequency is 350 Hz; after ultrasonic extraction, taking supernatant to obtain cacumen biotae extract, then carrying out centrifugal filtration on the cacumen biotae extract, collecting filtrate and recovering ethanol, and finally obtaining filtrate which is the cacumen biotae extract;

The embodiment provides a plant fermentation extract component shampoo and a preparation method thereof, and the preparation method comprises the following steps:

(1) the preparation method of the natural plant extract component compound comprises the following components in parts by weight:

components	Parts by weight
		Cacumen Platycladi extract	3.8
Mountain tea seed cake extract	3.8
		Ginger root extract	3.8
Ginseng root extract	3.5
		Forsythia fruit extract	3.5
Polygonum multiflorum root extract	3.5
		Caffeine	0.03
Propylene glycol	5
		Preservative	0.5
Water (W)	Balance of

The preparation method of the natural plant extract composition compound comprises the following steps:

sequentially adding the cacumen biotae extract, the camellia seed cake extract, the ginger root extract, the ginseng root extract, the forsythia fruit extract and the polygonum multiflorum root extract into a reaction kettle according to the mixture ratio of the table, uniformly stirring at the rotating speed of 700r/min, then adding caffeine, a preservative, propylene glycol and water, and continuously stirring at the rotating speed of 800r/min until the mixture is uniform, thus obtaining the natural plant extract component compound.

(2) The shampoo is prepared from the following components in parts by weight: 25 parts of natural plant extract component compound, 74.9 parts of shampoo medium, 0.06 part of preservative and 0.04 part of essence.

The preparation method comprises the following steps: and (2) adding the natural extraction component compound prepared in the step (1), the preservative and the essence into the shampoo matrix, continuously stirring at the rotating speed of 900r/min until the mixture is uniform, and then carrying out aseptic filling to obtain the shampoo.

The shampoo medium comprises 4 parts of cocamidopropyl betaine, 5 parts of sodium lauroyl sarcosinate, 0.6 part of cocamide DEA, 0.4 part of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.5 part of guar gum hydroxypropyl trimethyl ammonium chloride, 4 parts of polydimethylsiloxane, 3 parts of ammonium lauryl sulfate, 15 parts of sodium laureth sulfate and 42.4 parts of water.

The preservative comprises methylisothiazolinone and phenoxyethanol, wherein the weight ratio of methylisothiazolinone to phenoxyethanol is 10: 1.

example 2

The plant extracts were prepared in the same manner as in example 1

components	Parts by weight
		Cacumen Platycladi extract	4.2
Mountain tea seed cake extract	4.2
		Ginger root extract	4.2
Ginseng root extract	3.6
		Forsythia fruit extract	3.6
Polygonum multiflorum root extract	3.6
		Caffeine	0.04
Propylene glycol	4
		Preservative	0.4
Water (W)	Balance of

(2) The shampoo is prepared from the following components in parts by weight: 28 parts of natural plant extract component compound, 71.9 parts of shampoo medium, 0.05 part of preservative and 0.05 part of essence

The shampoo medium comprises 3.5 parts of cocamidopropyl betaine, 4.5 parts of sodium lauroyl sarcosinate, 0.8 part of cocamide DEA, 0.3 part of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.4 part of guar hydroxypropyl trimethyl ammonium chloride, 3.5 parts of polydimethylsiloxane, 4 parts of ammonium lauryl sulfate, 13 parts of sodium laureth sulfate and 41.9 parts of water.

example 3

components	Parts by weight
		Cacumen Platycladi extract	3.3
Mountain tea seed cake extract	3.3
		Ginger root extract	3.3
Ginseng root extract	3.8
		Forsythia fruit extract	3.8
Polygonum multiflorum root extract	3.8
		Caffeine	0.03
Propylene glycol	3.5
		Preservative	0.3
Water (W)	Balance of

(2) The shampoo is prepared from the following components in parts by weight: 22 parts of natural plant extract component compound, 77.9 parts of shampoo medium, 0.07 part of preservative and 0.03 part of essence

The shampoo medium comprises 4.5 parts of cocamidopropyl betaine, 4.2 parts of sodium lauroyl sarcosinate, 1.0 part of cocamide DEA, 0.2 part of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.3 part of guar hydroxypropyl trimethyl ammonium chloride, 3.5 parts of polydimethylsiloxane, 3 parts of ammonium lauryl sulfate, 16 parts of sodium laureth sulfate and 45.2 parts of water.

example 4

The present example provides a plant fermentation extract shampoo and a preparation method thereof, and the specific implementation manner is the same as example 1, except that the natural plant extract composition does not include caffeine.

Example 5

The embodiment of the invention provides plant fermentation extract component shampoo and a preparation method thereof, and the specific implementation manner is the same as that of embodiment 1, and the differences are that the weight parts of the cacumen biotae extract, the camellia seed cake extract and the ginger root extract are 3.8 parts, 3.9 parts and 3.7 parts respectively.

Example 6

The embodiment of the invention provides a shampoo with plant fermentation extract components and a preparation method thereof, and the specific implementation mode is the same as that of the embodiment 1, except that no cocamide DEA is contained.

Evaluation of Performance

1. Clinical trial

Since hair loss is mostly seen in men, 60 volunteers with hair loss were recruited and aged between 25 and 55 years, and the shampoo obtained in example 1 was tested.

The test method comprises the following steps: scalp tissues of each group of volunteers before and after the shampoo was used were scraped, and the average mRNA expression levels of insulin growth factor-1 and hepatocyte growth factor in the scalp tissues before and after the use were measured by qRT-PCR, and the results are shown in table 1.

TABLE 1

Numbering	Insulin growth factor-1	Hepatocyte growth factor
			Example 1	The improvement is 52 percent	Increase by 150 percent

2. Animal testing

60 mice are adopted, 10 mice are used in each group, 10 mice are used in the blank group, unhairing operation is carried out on each group of experimental bodies and the blank group, the experimental bodies in each group are respectively smeared with the natural plant extract composition compound prepared in the embodiment 1-5, the hair growth condition of the mice in 4 weeks is observed, the expression quantity change of the beta-catenin is detected, and the result is shown in a table 2.

TABLE 2

Numbering	Average expression level change of beta-catenin
		Example 1	The improvement is 61.8 percent
Example 2	The improvement is 60.2 percent
		Example 3	The improvement is 61.0 percent
Example 4	The improvement is 35.1 percent
		Example 5	The improvement is 45.6 percent

3. Stability test

The shampoos prepared in examples 1-3 and 6 were subjected to stability test, left at room temperature, -10 ℃ and 40 ℃ for 2 weeks, and observed for the state of the shampoo, and the results are shown in Table 3.

TABLE 3

The results in tables 1-3 show that the natural plant extract composition prepared by the invention and the shampoo product prepared by the natural plant extract composition can activate hair follicle cells, promote cell division, provide normal metabolism and required biological activity for hair, and further achieve the effect of preventing alopecia; meanwhile, the shampoo prepared by the invention has excellent stability and can be produced in large scale.

Finally, it should be understood that the above-described embodiments are merely preferred embodiments of the present invention, and not intended to limit the present invention, and any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A shampoo with plant fermentation and extraction components is characterized by comprising the following components in parts by weight: 20-30 parts of natural plant extract component compound, 65-80 parts of shampoo matrix, 0.05-0.1 part of preservative and 0.02-0.05 part of essence.

2. The plant fermentation extract shampoo as claimed in claim 1 wherein the natural plant extract composition comprises cacumen Platycladi extract, camellia seed cake extract, ginger root extract, ginseng root extract, fructus forsythiae extract, radix Polygoni Multiflori extract, caffeine, preservative, moisturizer, and water.

3. The shampoo with plant fermentation extracted components as claimed in claim 1 or 2, wherein the natural plant extracted component compound comprises, by weight, 3-5 parts of cacumen biotae extract, 3-5 parts of camellia seed cake extract, 3-5 parts of ginger root extract, 2-4 parts of ginseng root extract, 2-4 parts of forsythia fruit extract, 2-4 parts of polygonum multiflorum root extract, 0.03-0.05 part of caffeine, 3-6 parts of humectant, 0.3-0.6 part of preservative, and the balance of water.

4. The shampoo with plant fermentation extracted ingredients as claimed in claim 1, wherein the shampoo matrix comprises 6.5-12 parts by weight of surfactant, 0.3-1.0 part by weight of thickener, 3-5 parts by weight of softener, 14-22 parts by weight of foaming agent and 25-48 parts by weight of water.

5. The shampoo with plant fermentation extracted ingredients as claimed in claim 4, wherein the surfactant comprises 2-5 parts of cocamidopropyl betaine, 4-6 parts of sodium lauroyl sarcosinate, and 0.5-1.0 part of cocamide DEA.

6. The shampoo with plant fermentation extracted ingredients as claimed in claim 4, wherein the thickener comprises 0.1-0.5 part of acrylate/C10-30 alkanol acrylate cross-linked polymer and 0.2-0.5 part of guar hydroxypropyltrimonium chloride.

7. The phytofermental extract shampoo of claim 4 wherein said conditioner comprises polydimethylsiloxane.

8. The shampoo of claim 4, wherein the foaming agent comprises ammonium laureth sulfate 2-4 parts and sodium laureth sulfate 12-18 parts.

9. The phytofermental extract shampoo of claim 1 or 2 wherein said preservative comprises methylisothiazolinone and phenoxyethanol in a weight ratio of 10: 1.

10. a method of producing a plant fermentation extract shampoo according to any one of claims 1 to 9, comprising the steps of:

(1) preparing a natural plant extract component compound:

(2) preparing the shampoo: