CN113615709A - Quaternary ammonium salt disinfectant - Google Patents
Quaternary ammonium salt disinfectant Download PDFInfo
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Abstract
The invention relates to a quaternary ammonium salt disinfectant, which comprises 100 parts by weight of water, 0.1-1 part by weight of quaternary ammonium salt and 1-10 parts by weight of nano mesoporous tantalum oxide solution. The benzalkonium chloride disclosed by the invention is basically non-toxic, has no teratogenic and carcinogenic toxicity, and is good in safety when being used for pregnant and lying-in women and infants. Benzalkonium chloride belongs to a surfactant, so that the benzalkonium chloride has double functions of cleaning and disinfection. Can be applied to various environments.
Description
Technical Field
The invention relates to a quaternary ammonium salt disinfectant.
Background
According to GB26373-2010 ethanol disinfectant sanitary Standard, the ethanol disinfectant contains 70-80% of ethanol. In general, the ethanol disinfectant has high ethanol content and strong volatility, and the volatile gas is easy to generate combustion accidents when meeting open fire. It has been reported that in the operation of patients after ethanol disinfection, the ethanol disinfection solution can cause burn accidents when meeting electric sparks of electric scalpels. High concentrations of alcohol disinfectants may also be extremely sensitive to human skin. The disinfection solution of 70% -80% ethanol or 65% -80% isopropanol has good disinfection effect, but has considerable risks in use and storage. The ethanol or isopropanol disinfectant is easily affected by the environment in the transportation and storage processes, and the strong volatile disinfectant is easy to escape from a packaging bottle to cause the effective concentration of the disinfectant to be reduced. When the alcohol concentration is lower than the specified concentration of the disinfectant, the disinfection effect is remarkably reduced.
The double-chain quaternary ammonium salt compound as the disinfectant has the advantages of stable performance, small toxicity irritation, low corrosivity, small smell and the like. Meanwhile, the double-chain quaternary ammonium salt disinfectant has good biodegradability and no pollution to the environment (water area), so that the double-chain quaternary ammonium salt disinfectant can be widely applied to disinfection of industrial and agricultural, hospital, family and public environmental sanitation. The quaternary ammonium salt compound is a cationic surfactant, and the sterilization mechanism of the quaternary ammonium salt compound is as follows: 1. changing the permeability of a thallus membrane to kill thallus; 2. the surface activity is good, the bacterial cell surface is gathered, and the bacterial metabolism is influenced; 3. denaturing the protein; 4. the enzyme system of the bacteria is inactivated. The quaternary ammonium salt disinfectant has an inhibiting effect on most bacteria at a concentration of 5mg/L, and has a strong bactericidal ability at a concentration of 100 mg/L.
In the prior art, the disinfectant can be applied to a large number of places of various types, and because the quaternary ammonium salt disinfectant can achieve a certain disinfection effect only after a certain period of time, metal ions on the surfaces of metal medical instruments and the like can influence the bactericidal activity of the quaternary ammonium salt disinfectant, and the disadvantage of narrow amplified quaternary ammonium salt antibacterial spectrum and weak bactericidal capacity is overcome.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a quaternary ammonium salt disinfectant, which comprises 100 parts by weight of water, 0.1-1 part by weight of quaternary ammonium salt and 1-10 parts by weight of nano mesoporous tantalum oxide solution. The nano mesoporous tantalum oxide solution comprises benzotriazole with the weight part of 1-10% of nano mesoporous tantalum oxide.
The quaternary ammonium salt is one or more of single-chain quaternary ammonium salt, double-chain quaternary ammonium salt and polymeric quaternary ammonium salt.
The single-chain quaternary ammonium salt is one or more of benzalkonium chloride, benzalkonium bromide, tetradecyl dimethyl pyridine ammonium bromide, hydroxyethyl dodecyl dimethyl phenoxy ethyl ammonium bromide and n-alkyl dimethyl benzyl ammonium chloride.
The single-chain quaternary ammonium salt is one or more of didecyl dimethyl ammonium bromide, didecyl dimethyl ammonium chloride, bis (dodecyl dimethyl) ethylene diammonium bromide, dioctyldimethyl ammonium chloride and didecyl dimethyl ammonium chloride.
The quaternary ammonium salt comprises 0.2-0.3 part by weight of polyaminopropyl biguanide and 0.05-0.15 part by weight of benzalkonium chloride.
The nano tantalum oxide solution is prepared by the following steps:
dissolving 1-10 parts by weight of tantalum pentachloride in 100 parts by weight of absolute ethanol, adding 1-10 parts by weight of octadecylamine to obtain an ethanol solution of tantalum pentachloride, and standing for 30-90 minutes;
uniformly mixing 1-10 parts by weight of sodium metavanadate solution and tantalum pentachloride ethanol solution to obtain tantalum metavanadate and tantalum pentachloride mixed solution, wherein the sodium metavanadate solution is an aqueous solution containing 10-50 wt% of sodium metavanadate;
keeping stirring the mixed solution of tantalum pentachloride metavanadate, and dripping 100 parts by weight of ethanol aqueous solution into the mixed solution of tantalum pentachloride metavanadate at the speed of 3-10 ml/min;
adding 50-150 parts by weight of N, N-dimethylformamide into every 100 parts by weight of tantalum pentachloride metavanadate mixed solution, keeping stirring for 30 minutes, standing for 1-3 hours at room temperature, soaking for 6-24 hours at 30-45 ℃, heating to 40-45 ℃, drying for 12-48 hours, heating to 100-160 ℃, and drying to constant weight to obtain dry powder;
and placing the dried powder in a muffle furnace, and calcining at the temperature of 400-500 ℃ to obtain the nano mesoporous tantalum oxide.
Mixing 10 parts by weight of nano mesoporous tantalum oxide, 1-10 parts by weight of water and 0.1-1 part by weight of benzotriazole, dispersing at high speed for 10-30 minutes, heating to 50-80 ℃, keeping for 1-3 hours, cooling to room temperature, continuously adding 40-80 parts by weight of water, and dispersing to obtain a nano mesoporous tantalum oxide solution.
The quaternary ammonium salt disinfectant has stable performance and small influence of pH value, and has strong killing effect on bacterial propagules and good killing effect on partial viruses and fungi. Even has better destructive effect on HBsAg. The disinfectant has the advantages of mildest performance and most extensive application, is nontoxic and high-level disinfectant, and integrates high-level disinfection, high-efficiency cleaning and double effects;
the double-chain quaternary ammonium salt disinfectant is characterized in that:
1. because the double-chain quaternary ammonium salt is a cationic surfactant and has extremely strong surface activity, the disinfectant effect is not interfered by organic matters and is not easily interfered by factors such as PH value, water quality, temperature and the like;
2. because the double-chain quaternary ammonium salt has strong surface activity and is matched with a solvent system with strong decontamination effect, the double-chain quaternary ammonium salt has double functions of disinfection and decontamination;
3. overall resistance to drug resistance;
4. can kill 99.9% of bacteria, fungi, methicillin-resistant Staphylococcus aureus, Bacillus difficile, Acinetobacter baumannii, tubercle bacillus, film virus (such as HIV, HBV, HCV, avian influenza virus, H2NI virus, SARS virus, etc.), vaccinia virus, bovine viral diarrhea mucosis virus, adenovirus and rotavirus. Coronaviruses belong to the enveloped lipophilic group of viruses. Enveloped viruses belong to the most readily killed microorganisms, in terms of the magnitude of resistance of all microorganisms recognized by humans to sterilization treatment. Can effectively kill coronavirus.
The benzalkonium chloride is basically non-toxic and has no teratogenic and carcinogenic toxicity, and the benzalkonium chloride has good safety when being used for pregnant and lying-in women and infants.
Benzalkonium chloride belongs to a surfactant, so that the benzalkonium chloride has double functions of cleaning and disinfection.
The above-described and other features, aspects, and advantages of the present application will become more apparent with reference to the following detailed description.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the invention without any inventive step, are within the scope of protection of the invention.
Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. The use of "first," "second," and similar terms in the description and claims of the present application do not denote any order, quantity, or importance, but rather the terms are used to distinguish one element from another. Also, the use of the terms "a" or "an" and the like do not denote a limitation of quantity, but rather denote the presence of at least one.
Preparing a nano tantalum oxide solution:
dissolving 5 parts by weight of tantalum pentachloride in 100 parts by weight of absolute ethanol, adding 5 parts by weight of octadecylamine to obtain an ethanol solution of tantalum pentachloride, and standing for 60 minutes;
uniformly mixing 5 parts by weight of sodium metavanadate solution and tantalum pentachloride ethanol solution to obtain tantalum metavanadate pentachloride mixed solution, wherein the sodium metavanadate solution is an aqueous solution containing 40 wt% of sodium metavanadate;
keeping stirring the mixed solution of tantalum pentachloride metavanadate, and dripping 100 parts by weight of ethanol water solution into the mixed solution of tantalum pentachloride metavanadate at the speed of 10 ml/min;
adding 100 parts by weight of N, N-dimethylformamide into 100 parts by weight of tantalum pentachloride metavanadate mixed solution, keeping stirring for 30 minutes, standing for 2 hours at room temperature, soaking for 24 hours at 40 ℃, heating to 45 ℃, drying for 24 hours, heating to 160 ℃, and drying to constant weight to obtain dry powder;
and (3) placing the dried powder in a muffle furnace, and calcining at 500 ℃ to obtain the nano mesoporous tantalum oxide.
Mixing 10 parts by weight of nano mesoporous tantalum oxide, 5 parts by weight of water and 1 part by weight of benzotriazole, dispersing at a high speed for 20 minutes, heating to 80 ℃, keeping for 3 hours, cooling to room temperature, continuously adding 80 parts by weight of water, and dispersing to obtain a nano mesoporous tantalum oxide solution.
Example 1
The disinfectant comprises 100 parts by weight of water, 0.3 part by weight of polyaminopropyl biguanide, 0.15 part by weight of benzalkonium chloride and 10 parts by weight of nano mesoporous tantalum oxide solution.
Example 2
The disinfectant comprises 100 parts by weight of water, 0.2 part by weight of polyaminopropyl biguanide, 0.1 part by weight of benzalkonium chloride and 5 parts by weight of nano mesoporous tantalum oxide solution.
Comparative example 1
The preparation method of the nano mesoporous tantalum oxide solution (N, N-dimethylformamide instead of benzotriazole) is the following steps:
dissolving 5 parts by weight of tantalum pentachloride in 100 parts by weight of absolute ethanol, adding 5 parts by weight of octadecylamine to obtain an ethanol solution of tantalum pentachloride, and standing for 60 minutes;
uniformly mixing 5 parts by weight of sodium metavanadate solution and tantalum pentachloride ethanol solution to obtain tantalum metavanadate pentachloride mixed solution, wherein the sodium metavanadate solution is an aqueous solution containing 40 wt% of sodium metavanadate;
keeping stirring the mixed solution of tantalum pentachloride metavanadate, and dripping 100 parts by weight of ethanol water solution into the mixed solution of tantalum pentachloride metavanadate at the speed of 10 ml/min;
adding 100 parts by weight of N, N-dimethylformamide into 100 parts by weight of tantalum pentachloride metavanadate mixed solution, keeping stirring for 30 minutes, standing for 2 hours at room temperature, soaking for 24 hours at 40 ℃, heating to 45 ℃, drying for 24 hours, heating to 160 ℃, and drying to constant weight to obtain dry powder;
and (3) placing the dried powder in a muffle furnace, and calcining at 500 ℃ to obtain the nano mesoporous tantalum oxide.
Mixing 10 parts by weight of nano mesoporous tantalum oxide, 5 parts by weight of water and 1 part by weight of N, N-dimethylformamide, dispersing at a high speed for 20 minutes, heating to 80 ℃, keeping the temperature for 3 hours, cooling to room temperature, continuously adding 80 parts by weight of water, and dispersing to obtain a nano mesoporous tantalum oxide solution.
Comparative example 2
The preparation method of the nano tantalum oxide solution (without adding octadecylamino) is as follows, similar to example 1:
dissolving 5 parts by weight of tantalum pentachloride in 100 parts by weight of absolute ethanol to obtain an ethanol solution of tantalum pentachloride, and standing for 60 minutes;
uniformly mixing 5 parts by weight of sodium metavanadate solution and tantalum pentachloride ethanol solution to obtain tantalum metavanadate pentachloride mixed solution, wherein the sodium metavanadate solution is an aqueous solution containing 40 wt% of sodium metavanadate;
keeping stirring the mixed solution of tantalum pentachloride metavanadate, and dripping 100 parts by weight of ethanol water solution into the mixed solution of tantalum pentachloride metavanadate at the speed of 10 ml/min;
adding 100 parts by weight of N, N-dimethylformamide into 100 parts by weight of tantalum pentachloride metavanadate mixed solution, keeping stirring for 30 minutes, standing for 2 hours at room temperature, soaking for 24 hours at 40 ℃, heating to 45 ℃, drying for 24 hours, heating to 160 ℃, and drying to constant weight to obtain dry powder;
and (3) placing the dried powder in a muffle furnace, and calcining at 500 ℃ to obtain the nano mesoporous tantalum oxide.
Mixing 10 parts by weight of nano mesoporous tantalum oxide, 5 parts by weight of water and 1 part by weight of benzotriazole, dispersing at a high speed for 20 minutes, heating to 80 ℃, keeping for 3 hours, cooling to room temperature, continuously adding 80 parts by weight of water, and dispersing to obtain a nano mesoporous tantalum oxide solution.
Comparative example 3
The same as example 1, 10 parts by weight of the nano mesoporous tantalum oxide solution was not added.
The test strains were carried out according to the requirements of the "Disinfection Specification" (2002 edition): and E, putting an Escherichia coli (ATCC 25922) infected carrier into a sterilizer, taking out the carrier in an aseptic procedure after a disinfection solution works for a period (6 minutes and 45 seconds, spraying for 45 seconds and standing for 6 minutes), putting the carrier into a neutralizer, oscillating and eluting, recovering and counting residual bacteria, and simultaneously putting the infected carrier at room temperature for the same time as a positive control for recovering and counting.
Neutralizing agent: phosphate buffer solution of 10g/L glycine, 5g/L lecithin and 80g/L Tween 80
A sterilizing machine: full-automatic cleaning and sterilizing machine for medical instruments, Reidmayp
A bacterial contamination carrier: and (5) placing the bacteria-contaminated carrier into a purification workbench for blow-drying for later use.
The temperature of the working environment is 23-25 ℃, and the relative humidity is 35-45%.
According to GB-15979-2002, the killing effect of example 1 on Escherichia coli is as follows:
according to GB-15979-2002, the killing effect of example 1 on staphylococcus aureus is as follows:
according to GB-15979-: (the numbers listed in the following table and the contents thereof are the same as BG 15979-2002)
It can be seen that the compositions of the present invention can be well adapted to a variety of environments. The nano particles with the mesopores are obtained by adding the octadecylamine, the benzotriazole is introduced into the nano particles, the benzotriazole can generate extremely stable coordination with metal ions, and the nano particles with the mesopores are selected, so that the aggregation capability of the metal ions in the nano particles is greatly improved, the comprehensive permeation and migration of the metal ions in a disinfectant are reduced, and the influence of the metal ions on the bactericidal compound can be reduced.
While there have been shown and described what are at present considered the fundamental principles and essential features of the invention and its advantages, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and the description is given here only for clarity, and those skilled in the art should integrate the description, and the embodiments may be combined appropriately to form other embodiments understood by those skilled in the art.
Claims (6)
1. The quaternary ammonium salt disinfectant is characterized by comprising 100 parts by weight of water, 0.1-1 part by weight of quaternary ammonium salt and 1-10 parts by weight of nano mesoporous tantalum oxide solution, wherein the nano mesoporous tantalum oxide solution comprises 1-10% by weight of benzotriazole of nano mesoporous tantalum oxide.
2. The quaternary ammonium salt disinfectant as set forth in claim 1, wherein the quaternary ammonium salt is one or more of a single-chain quaternary ammonium salt, a double-chain quaternary ammonium salt and a polymeric quaternary ammonium salt.
3. The quaternary ammonium salt disinfectant as set forth in claim 2, wherein the single-chain quaternary ammonium salt is one or more of benzalkonium chloride, benzalkonium bromide, tetradecyl dimethyl pyridinium bromide, hydroxyethyl dodecyl dimethyl phenoxyethyl ammonium bromide and n-alkyl dimethyl benzyl ammonium chloride.
4. The quaternary ammonium salt disinfectant as set forth in claim 2, wherein the single-chain quaternary ammonium salt is one or more of didecyldimethyl ammonium bromide, didecyldimethyl ammonium chloride, bis (dodecyldimethyl) ethylenediammonium bromide, dioctyldimethyl ammonium chloride and didecyldimethyl ammonium chloride.
5. The quaternary ammonium salt disinfectant as set forth in claim 1, wherein the quaternary ammonium salt is 0.2-0.3 parts by weight of polyaminopropyl biguanide and 0.05-0.15 parts by weight of benzalkonium chloride.
6. The quaternary ammonium salt disinfectant solution according to claim 1, wherein the nano tantalum oxide solution is prepared by the following steps:
dissolving 1-10 parts by weight of tantalum pentachloride in 100 parts by weight of absolute ethanol, adding 1-10 parts by weight of octadecylamine to obtain an ethanol solution of tantalum pentachloride, and standing for 30-90 minutes;
uniformly mixing 1-10 parts by weight of sodium metavanadate solution and tantalum pentachloride ethanol solution to obtain tantalum metavanadate and tantalum pentachloride mixed solution, wherein the sodium metavanadate solution is an aqueous solution containing 10-50 wt% of sodium metavanadate;
keeping stirring the mixed solution of tantalum pentachloride metavanadate, and dripping 100 parts by weight of ethanol aqueous solution into the mixed solution of tantalum pentachloride metavanadate at the speed of 3-10 ml/min;
adding 50-150 parts by weight of N, N-dimethylformamide into every 100 parts by weight of tantalum pentachloride metavanadate mixed solution, keeping stirring for 30 minutes, standing for 1-3 hours at room temperature, soaking for 6-24 hours at 30-45 ℃, heating to 40-45 ℃, drying for 12-48 hours, heating to 100-160 ℃, and drying to constant weight to obtain dry powder;
placing the dried powder in a muffle furnace, and calcining at the temperature of 400-500 ℃ to obtain the nano mesoporous tantalum oxide;
mixing 10 parts by weight of nano mesoporous tantalum oxide, 1-10 parts by weight of water and 0.1-1 part by weight of benzotriazole, dispersing at high speed for 10-30 minutes, heating to 50-80 ℃, keeping for 1-3 hours, cooling to room temperature, continuously adding 40-80 parts by weight of water, and dispersing to obtain a nano mesoporous tantalum oxide solution.
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