CN113508114A - 以氮杂环丁烷衍生物为活性成分的口服药物组合物、其制备方法及用途 - Google Patents
以氮杂环丁烷衍生物为活性成分的口服药物组合物、其制备方法及用途 Download PDFInfo
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- CN113508114A CN113508114A CN202080007400.9A CN202080007400A CN113508114A CN 113508114 A CN113508114 A CN 113508114A CN 202080007400 A CN202080007400 A CN 202080007400A CN 113508114 A CN113508114 A CN 113508114A
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Abstract
涉及以氮杂环丁烷衍生物为活性成分的口服药物组合物及其制备方法和用途。所述口服药物组合物的制备工艺简便稳定，中间体物料的API含量和混合均匀度好，所得到的制剂成品溶出快，质量稳定，适合工业放大生产。
Description
PCT国内申请，说明书已公开。
Claims (1)
- PCT国内申请，权利要求书已公开。
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| Application Number | Priority Date | Filing Date | Title |
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| CN2019101444604 | 2019-02-27 | ||
| CN201910144460 | 2019-02-27 | ||
| PCT/CN2020/075913 WO2020173364A1 (zh) | 2019-02-27 | 2020-02-20 | 以氮杂环丁烷衍生物为活性成分的口服药物组合物、其制备方法及用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116444529A (zh) * | 2023-06-16 | 2023-07-18 | 北京科翔中升医药科技有限公司 | 一种氘代氮杂环丁烷类jak抑制剂及其用途 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020240586A1 (en) * | 2019-05-28 | 2020-12-03 | Mankind Pharma Ltd. | Novel compounds for inhibition of janus kinase 1 |
| CN112159394B (zh) * | 2020-10-09 | 2021-10-22 | 嘉兴特科罗生物科技有限公司 | 一种作为jak激酶抑制剂的小分子化合物及其用途 |
| TW202345824A (zh) * | 2022-03-18 | 2023-12-01 | 大陸商四川科倫博泰生物醫藥股份有限公司 | 氮雜環丁烷衍生物的用途及治療方法 |
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| CN102026999A (zh) * | 2008-03-11 | 2011-04-20 | 因塞特公司 | 作为jak抑制剂的氮杂环丁烷和环丁烷衍生物 |
| CN103705485A (zh) * | 2013-12-31 | 2014-04-09 | 广州帝奇医药技术有限公司 | 一种用于治疗骨髓增生异常综合症的组合物及其制备方法 |
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| WO2017097224A1 (zh) * | 2015-12-11 | 2017-06-15 | 四川科伦博泰生物医药股份有限公司 | 氮杂环丁烷衍生物、其制备方法及用途 |
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| CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
| WO2013173506A2 (en) * | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| RU2601410C1 (ru) * | 2015-11-13 | 2016-11-10 | ЗАО "Р-Фарм" | {3-[(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)АЗОЛИЛ]АЗЕТИДИН-3-ИЛ}АЦЕТОНИТРИЛЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС КИНАЗ |
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- 2020-02-20 WO PCT/CN2020/075913 patent/WO2020173364A1/zh active Application Filing
- 2020-02-20 CN CN202080007400.9A patent/CN113508114B/zh active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101568330A (zh) * | 2006-06-30 | 2009-10-28 | 伊休蒂卡有限公司 | 用于制备纳米粒形式的生物活性化合物的方法 |
| CN102026999A (zh) * | 2008-03-11 | 2011-04-20 | 因塞特公司 | 作为jak抑制剂的氮杂环丁烷和环丁烷衍生物 |
| CN103705485A (zh) * | 2013-12-31 | 2014-04-09 | 广州帝奇医药技术有限公司 | 一种用于治疗骨髓增生异常综合症的组合物及其制备方法 |
| CN106551912A (zh) * | 2015-09-29 | 2017-04-05 | 南京优科制药有限公司 | 一种提高难溶性药物溶出度的方法 |
| WO2017097224A1 (zh) * | 2015-12-11 | 2017-06-15 | 四川科伦博泰生物医药股份有限公司 | 氮杂环丁烷衍生物、其制备方法及用途 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116444529A (zh) * | 2023-06-16 | 2023-07-18 | 北京科翔中升医药科技有限公司 | 一种氘代氮杂环丁烷类jak抑制剂及其用途 |
| CN116444529B (zh) * | 2023-06-16 | 2023-12-05 | 药康众拓(江苏)医药科技有限公司 | 一种氘代氮杂环丁烷类jak抑制剂及其用途 |
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| CN113508114B (zh) | 2024-03-26 |
| WO2020173364A1 (zh) | 2020-09-03 |
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