CN113413494A - Injection equipment for detoxifying injection for snake bite emergency treatment and preparation method thereof - Google Patents
Injection equipment for detoxifying injection for snake bite emergency treatment and preparation method thereof Download PDFInfo
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- CN113413494A CN113413494A CN202110539691.2A CN202110539691A CN113413494A CN 113413494 A CN113413494 A CN 113413494A CN 202110539691 A CN202110539691 A CN 202110539691A CN 113413494 A CN113413494 A CN 113413494A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/008—Supramolecular polymers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/04—Alginic acid; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/24—Acids; Salts thereof
- C08K3/26—Carbonates; Bicarbonates
- C08K2003/265—Calcium, strontium or barium carbonate
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to the technical field of biological materials and medical treatment, in particular to injection equipment for detoxifying injection for snake bite emergency treatment and a preparation method thereof, wherein the injection equipment comprises a suction cup, an outer needle cylinder, an outer piston shaft, an outer piston handle, an inner needle cylinder, a needle head, an inner piston rod and an inner piston handle, the front end of the outer needle cylinder is communicated with the rear end of the suction cup through a connecting channel, and the outer piston slides in a matching way with the inner cavity of the outer needle cylinder; the detoxification injection comprises calcium oxalate hydrogel and a metal organic framework; the calcium oxalate hydrogel is prepared from Sodium Alginate (SA), calcium carbonate and Gluconolactone (GDL); the metal organic framework is prepared from 2-methylimidazole and zinc nitrate hexahydrate, N, N-dimethylformamide. The injection makes up the defects of other detoxification products such as serum and the like, can delay the time that toxin enters blood circulation for nearly 1h, and strives for precious time for patients to obtain professional treatment.
Description
Technical Field
The invention relates to the technical field of biological materials and medical treatment, in particular to injection equipment for detoxifying injection for snake bite emergency treatment and a preparation method thereof.
Background
Snake bites are a problem affecting public health and safety around the world. According to statistics, about 400 million people suffer from snake bite every year around the world, wherein about 10 million people die, about 40 million people are permanently disfigured or disabled, and 180 to 270 million people have serious clinical symptoms of neuromuscular toxicity, tissue injury, acute kidney injury and the like. At present, the most effective treatment method in China is the traditional antivenin, although the antivenin has certain treatment effect on some common snake bites, the storage and transportation conditions of the bioprotein products are strictly limited, and timely and accurate treatment is difficult to obtain after the bioprotein products are bitten by the poisonous snakes in the field. And domestic anti-snake venom serum production companies meeting the standards are few and few, the annual output is low, and the current situation of short supply and short demand appears in the market.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, provides injection equipment for detoxifying injection for snake bite emergency treatment and a preparation method thereof, and realizes the emergency injection integrating three properties of detoxifying, blocking and detoxifying.
In order to realize the purpose of the invention, the invention adopts the technical scheme that:
the invention discloses injection equipment for detoxifying injection for snake bite emergency treatment, which comprises an absorption cup, an outer needle cylinder, an outer piston shaft, an outer piston handle, an inner needle cylinder, a needle head, an inner piston rod and an inner piston handle,
the outer needle cylinder is of a hollow cylindrical structure with an opening at the rear end, the front end of the outer needle cylinder is communicated with the rear end of the suction cup through a connecting passage, and the suction cup is of a hollow cylindrical structure with an opening at the front end; the outer piston slides in a matching way with the inner cavity of the outer needle cylinder, the outer piston shaft is of an annular structure, the front end of the outer piston shaft is connected with the rear wall of the outer piston, and the rear end of the outer piston shaft is connected with the outer piston handle;
a through hole for the inner needle cylinder to pass through is axially formed in the outer piston, the inner piston slides in a matched manner with the inner cavity of the inner needle cylinder, the front end of the inner piston rod is axially connected with the rear wall of the inner piston, and the rear end of the inner piston rod passes through the outer piston handle and then is connected with the inner piston handle; the needle is arranged at the front end of the inner needle cylinder and communicated with the inner cavity of the inner needle cylinder, and the inner cavity of the inner needle cylinder is internally provided with a detoxifying injection.
The connecting channel is of a tubular structure, the inner diameter of the connecting channel is smaller than the outer diameter of the inner needle cylinder, and the outer diameter of the inner needle cylinder is smaller than the inner diameter of the suction cup.
The invention discloses a preparation method of detoxification injection for snake bite emergency treatment, which comprises calcium oxalate hydrogel and a metal organic framework ZIF-8,
the synthesis steps of the calcium oxalate hydrogel are as follows:
a) weigh 2.45g of a 2wt% sodium alginate solution (2g dissolved in 100mL ddH 2O);
b) 0.05g of calcium carbonate is added;
c) after stirring, adding 10mg of D- (+) -gluconic acid delta-lactone (GLD) and stirring for 10 s;
the synthesis steps of the metal organic framework ZIF-8 are as follows:
weighing 20mmol of Zn (NO3)2 & 6H2O and 70mmol of 2-methylimidazole;
dissolving the two solutions in 150mL of methanol (MeOH) respectively to form two transparent solutions;
mixing the two transparent solutions in the step II;
fourthly, mixing and stirring for 24 hours at room temperature to obtain white precipitate, centrifuging, washing with methanol for multiple times, and drying at 60 ℃.
The invention has the beneficial effects that:
1. the calcium sea oxalate hydrogel can play a role in plugging by the characteristics of the calcium sea oxalate hydrogel, rapidly prevent blood from diffusing to the far end, and then adsorb the metal organic framework solution for a long time.
2. The injection is easy to store and carry, and is convenient for self-rescue after snake bite.
3. The injection can delay the toxin from entering the blood of the whole body for nearly 1 hour, strive for precious time for the patient to go to the hospital for treatment and save the life of the patient.
Drawings
FIG. 1 is a schematic view of the injection device of the present invention;
FIG. 2 is a cross-sectional view of the injection device of the present invention;
FIG. 3 is an electron micrograph of bungarotoxin;
FIG. 4 is an electron micrograph of a metal organic framework ZIF-8;
FIG. 5 is an electron micrograph of a metal organic framework + bungarotoxin;
FIG. 6 is an XRD pattern of Zif-8 indicating successful preparation.
In the figure, a suction cup 1, an outer needle cylinder 2, an outer piston 3, an outer piston shaft 4, an outer piston handle 5, an inner needle cylinder 6, a needle 7, an inner piston 8, an inner piston rod 9, an inner piston handle 10 and a connecting channel 11.
Detailed Description
The invention is further illustrated with reference to the following figures and examples:
see fig. 1-6.
The invention discloses injection equipment for detoxifying injection for snake bite emergency treatment and a preparation method thereof, and the injection equipment comprises an absorption cup 1, an outer needle cylinder 2, an outer piston 3, an outer piston shaft 4, an outer piston handle 5, an inner needle cylinder 6, a needle head 7, an inner piston 8, an inner piston rod 9 and an inner piston handle 10, wherein the outer needle cylinder 2 is of a hollow cylindrical structure with an opening at the rear end, the front end of the outer needle cylinder is communicated with the rear end of the absorption cup 1 through a connecting channel 11, and the absorption cup 1 is of a hollow cylindrical structure with an opening at the front end; the outer piston 3 is matched with the inner cavity of the outer needle cylinder 2 to slide, the outer piston shaft 4 is of an annular structure, the front end of the outer piston shaft is connected with the rear wall of the outer piston 3, and the rear end of the outer piston shaft is connected with the outer piston handle 5;
a through hole for the inner needle cylinder 6 to pass through is axially formed in the outer piston 3, the inner piston 8 and the inner cavity of the inner needle cylinder 6 slide in a matched mode, the front end of the inner piston rod 9 is axially connected with the rear wall of the inner piston 8, and the rear end of the inner piston rod is connected with the inner piston handle 10 after passing through the outer piston handle 5; the needle head 7 is arranged at the front end of the inner needle cylinder 6 and is communicated with the inner cavity of the inner needle cylinder 6, and a detoxifying injection is arranged in the inner cavity of the inner needle cylinder 6, so that a person bitten can independently operate; the injection is easy to store and carry, and is convenient for self-rescue after snake bite.
The connecting channel 11 is of a tubular structure, the inner diameter of the connecting channel is smaller than the outer diameter of the inner needle cylinder 6, and the outer diameter of the inner needle cylinder 6 is smaller than the inner diameter of the suction cup 1.
The injection method comprises the following steps: opening the injection external package, pressing the suction cup 1 at the front part on the bite part with force, pulling the outer piston handle 5 at the rear part to suck out the superficial toxin, and then pulling out the suction cup 1; then, the inner piston handle 10 is pressed to slide the inner needle cylinder 6 along the axial through hole of the outer piston 3 until the front end of the inner needle cylinder 6 is contacted with the front wall of the inner cavity of the outer needle cylinder 2, and the inner calcium oxalate hydrogel and the metal organic frame injection are injected into the bite part through the needle head 7 by continuously pressing the inner piston handle 10.
The invention discloses a preparation method of detoxification injection for snake bite emergency treatment, which comprises calcium oxalate hydrogel and a metal organic framework ZIF-8,
the synthesis steps of the calcium oxalate hydrogel are as follows:
a) weigh 2.45g of a 2wt% sodium alginate solution (2g dissolved in 100mL ddH 2O);
b) 0.05g of calcium carbonate is added;
c) after stirring, adding 10mg of D- (+) -gluconic acid delta-lactone (GLD) and stirring for 10 s;
the synthesis steps of the metal organic framework ZIF-8 are as follows:
weighing 20mmol of Zn (NO3)2 & 6H2O and 70mmol of 2-methylimidazole;
dissolving the two solutions in 150mL of methanol (MeOH) respectively to form two transparent solutions;
mixing the two transparent solutions in the step II;
fourthly, mixing and stirring for 24 hours at room temperature to obtain white precipitate, centrifuging, washing with methanol for multiple times, and drying at 60 ℃.
35 KM mice (SJA laboratory animals Co., Ltd., Hunan, China) were selected for this experiment. The amount of the bungarus multicinctus or cobra injected into each mouse was 10 or 3 mg/kg. SA 0.1mL was injected, and ZIF-8 was injected twice as much as the venom.
Selecting mouse tail veins as an experimental model, setting 10 groups (at least 3 in each group) as (1) SA injection, (2) ZIF-8 injection, (3) SA and ZIF-8 injection as negative control groups, (4) golden trepang (venom) intravenous injection as positive control groups, (5) SA and ZIF-8 intravenous injection only at the upstream of snake venom for 1 min, (6) SA and ZIF-8 intravenous injection only at the upstream of venom for 1 min, (7) SA and ZIF-8 intravenous injection only at the upstream of snake venom for 5min, (8) SA and ZIF-8 intravenous injection only at the upstream of snake venom for 5min after snake venom injection, (9) SA and ZIF-8 intravenous injection only at the upstream of snake venom before injection, (10) SA and ZIF-8 intravenous injection at the upstream of snake venom before injection. After injection, the survival time of each mouse was observed and recorded.
The calcium oxalate hydrogel can block toxins in blood and slow down the speed of the toxins flowing to the heart; the metal organic framework can adsorb toxins in blood and reduce the amount of toxins flowing to the heart; the injection has longer quality guarantee period and no strict limitation on storage conditions; the experimental result shows that the calcium sea oxalate hydrogel has good biocompatibility with the metal organic framework; the detoxification injection can promote the healing of wounds while detoxifying, blocking poison and detoxifying; the experimental result shows that the novel detoxification injection for the first aid of snake bite can delay the toxin from entering the whole body through blood for nearly 1 hour; the synthesis process of the calcium sea oxalate hydrogel and the metal organic framework is simple and convenient, and the yield is high; the detoxification injection has the functions of adsorbing and detoxifying one toxin, and is generally applicable to at least three common biological protein toxins (neurotoxin, blood toxin and toxin mixture).
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent modifications made by the present invention and the contents of the drawings or directly or indirectly applied to the related technical fields are included in the scope of the present invention.
Claims (3)
1. An injection equipment of injection that detoxifies for snake bite first aid which characterized in that: comprises a suction cup (1), an outer needle cylinder (2), an outer piston (3), an outer piston shaft (4), an outer piston handle (5), an inner needle cylinder (6), a needle head (7), an inner piston (8), an inner piston rod (9) and an inner piston handle (10),
the outer needle cylinder (2) is of a hollow cylindrical structure with an opening at the rear end, the front end of the outer needle cylinder is communicated with the rear end of the suction cup (1) through a connecting passage (11), and the suction cup (1) is of a hollow cylindrical structure with an opening at the front end; the outer piston (3) is matched with the inner cavity of the outer needle cylinder (2) to slide, the outer piston shaft (4) is of an annular structure, the front end of the outer piston shaft is connected with the rear wall of the outer piston (3), and the rear end of the outer piston shaft is connected with the outer piston handle (5);
a through hole for the inner needle cylinder (6) to pass through is axially formed in the outer piston (3), the inner piston (8) and the inner cavity of the inner needle cylinder (6) slide in a matched mode, the front end of the inner piston rod (9) is axially connected with the rear wall of the inner piston (8), and the rear end of the inner piston rod is connected with the inner piston handle (10) after passing through the outer piston handle (5); the needle head (7) is arranged at the front end of the inner needle cylinder (6) and communicated with the inner cavity of the inner needle cylinder, and a detoxifying injection is arranged in the inner cavity of the inner needle cylinder (6).
2. An injection apparatus for injecting a detoxified injectate for emergency treatment of snake bites according to claim 1, characterized in that: the connecting channel (11) is of a tubular structure, the inner diameter of the connecting channel is smaller than the outer diameter of the inner needle cylinder (6), and the outer diameter of the inner needle cylinder (6) is smaller than the inner diameter of the suction cup (1).
3. The preparation method of the detoxification injection for the first aid of snake bite according to claim 1, which is characterized in that: consists of calcium oxalate hydrogel and a metal organic framework ZIF-8,
the synthesis steps of the calcium oxalate hydrogel are as follows:
a) weigh 2.45g of a 2wt% sodium alginate solution, 2g of which was dissolved in 100mL ddH 2O;
b) 0.05g of calcium carbonate is added;
c) after stirring, adding 10mg of D- (+) -gluconic acid delta-lactone (GLD) and stirring for 10 s;
the synthesis steps of the metal organic framework ZIF-8 are as follows:
weighing 20mmol of Zn (NO3)2 & 6H2O and 70mmol of 2-methylimidazole;
dissolving the two solutions in 150mL of methanol (MeOH) respectively to form two transparent solutions;
mixing the two transparent solutions in the step II;
fourthly, mixing and stirring for 24 hours at room temperature to obtain white precipitate, centrifuging, washing with methanol for multiple times, and drying at 60 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110539691.2A CN113413494B (en) | 2021-05-18 | 2021-05-18 | Injection equipment for detoxifying injection for snake bite emergency treatment and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110539691.2A CN113413494B (en) | 2021-05-18 | 2021-05-18 | Injection equipment for detoxifying injection for snake bite emergency treatment and preparation method thereof |
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| CN113413494A true CN113413494A (en) | 2021-09-21 |
| CN113413494B CN113413494B (en) | 2022-12-06 |
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Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5348543A (en) * | 1993-04-28 | 1994-09-20 | John Talley | Hypodermic needle guard system |
| CN101011611A (en) * | 2006-03-03 | 2007-08-08 | 杨运泰 | Suction-cup needleless injector |
| US20100100054A1 (en) * | 2008-10-21 | 2010-04-22 | Michel Cormier | Intravitreal injection device and system |
| US20120179092A1 (en) * | 2011-01-10 | 2012-07-12 | Russell Churchill | Snake Venom Evacuation and Medication Injection Device |
| CN102811754A (en) * | 2010-01-13 | 2012-12-05 | 第七感生物***有限公司 | Rapid delivery and/or withdrawal of fluids |
| CN206167475U (en) * | 2016-08-22 | 2017-05-17 | 李海霞 | Simple and easy snake venom suction ware |
| CN109674769A (en) * | 2019-02-13 | 2019-04-26 | 南昌大学 | A kind of preparation method and its application method of hydrogel local anaesthesia patch |
| CN110201254A (en) * | 2019-07-10 | 2019-09-06 | 河南科技大学第一附属医院 | A kind of flow diverter for tumour ponding |
| CN110951089A (en) * | 2019-12-23 | 2020-04-03 | 大连理工大学 | Method for promoting synthesis of ZIF-8 in aprotic polar solvent |
| CN111617348A (en) * | 2020-05-21 | 2020-09-04 | 尹颂华 | Breast drug delivery device with needleless injection |
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-
2021
- 2021-05-18 CN CN202110539691.2A patent/CN113413494B/en active Active
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| US5348543A (en) * | 1993-04-28 | 1994-09-20 | John Talley | Hypodermic needle guard system |
| CN101011611A (en) * | 2006-03-03 | 2007-08-08 | 杨运泰 | Suction-cup needleless injector |
| US20100100054A1 (en) * | 2008-10-21 | 2010-04-22 | Michel Cormier | Intravitreal injection device and system |
| CN102811754A (en) * | 2010-01-13 | 2012-12-05 | 第七感生物***有限公司 | Rapid delivery and/or withdrawal of fluids |
| US20120179092A1 (en) * | 2011-01-10 | 2012-07-12 | Russell Churchill | Snake Venom Evacuation and Medication Injection Device |
| CN206167475U (en) * | 2016-08-22 | 2017-05-17 | 李海霞 | Simple and easy snake venom suction ware |
| CN109674769A (en) * | 2019-02-13 | 2019-04-26 | 南昌大学 | A kind of preparation method and its application method of hydrogel local anaesthesia patch |
| CN110201254A (en) * | 2019-07-10 | 2019-09-06 | 河南科技大学第一附属医院 | A kind of flow diverter for tumour ponding |
| WO2021016400A1 (en) * | 2019-07-22 | 2021-01-28 | Aquavit Pharmaceuticals, Inc. | System and method for dual-function syringe design compounding device for personalized treatments |
| CN110951089A (en) * | 2019-12-23 | 2020-04-03 | 大连理工大学 | Method for promoting synthesis of ZIF-8 in aprotic polar solvent |
| CN111617348A (en) * | 2020-05-21 | 2020-09-04 | 尹颂华 | Breast drug delivery device with needleless injection |
| CN215134916U (en) * | 2021-04-02 | 2021-12-14 | 南昌大学 | Novel injection syringe detoxifies |
Non-Patent Citations (2)
| Title |
|---|
| RUOLEI LI等: "Metal-Organic Framework and Hydrogel Based Strategy as a Universal First-aid Treatment of Three Different Typical Snake Bites", 《ACS BIOMATERIALS SCIENCE&ENGINEERING》 * |
| 徐群娜等: "聚合物基MOFs复合材料的制备及应用", 《材料导报》 * |
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