CN109453278A - A kind of external application bacteriostatic Chinese medicinal particle and preparation method thereof - Google Patents
A kind of external application bacteriostatic Chinese medicinal particle and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention discloses a kind of external application bacteriostatic Chinese medicinal particles and preparation method thereof, including following raw material: kuh-seng, Cortex Phellodendri, wild chrysanthemum, dragon's blood, bombyx batryticatus, frutus cnidii, borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant, existing gynecologic medicine is solved to have a single function, material base is unclear, there are adverse reactions, there are side effects, the problems such as effect is unobvious, according to vaginitis at Anttdisease Mechanism, targetedly medication, under the guidance of traditional Chinese medical theory, diagnosis and treatment based on an overall analysis of the illness and the patient's condition, proportion prescription is carried out in conjunction with the pathogenesis and disease symptom of vaginitis, improve the permeability of blood vessel, it promotes blood circulation, enhance bacteriostasis；Unused preparation method is used according to the characteristic of different pharmaceutical, effective component therein can sufficiently be extracted；It can fundamentally be reconciled, be had no toxic side effect from human body, it is efficient high, it is practical；Have effects that simultaneously antibacterial and two kinds of health care.
Description
Technical field
The invention belongs to Amino-Cerv technical fields, and in particular to a kind of external application bacteriostatic Chinese medicinal particle and preparation method thereof.
Background technique
Currently, female vagina, cervicitis, adnexitis etc. are the common and multiple diseases of middle aged and aged women, are directly affected
The body and mind Jiankang of women and love life also will affect U.S. face, lead to premature aging occur.Due to the spy of female sex organ
Different property, gynaecological imflammation have become common, the frequently-occurring disease of adult female, and clinical manifestation is varied, and the cause of disease is complicated and is often accompanied by
A variety of Complicated with Severe diseases, have a significant impact to the life and work of women.
Antibacterial medicines currently used for gynaecology are many kinds of, but most of antibacterial medicines are with acidic disinfectant by one
Determine the product that concentration requires production, such drug, which is used for a long time, to be caused to damage to vagina skin and mucous membrane, or even causes tissue
Hyperplasia.Simultaneously it is indefinite to there is big inconvenient for use, dosage, complicated component, active component more in compound medicine, and now very much
Drug only has restraining and sterilizing bacteria effect, and a subsequent health care can not be played to vagina and restitution, effect are single；It is risen in compound
The problems such as material base of curative effect is unclear, and there are certain adverse reactions；Therefore develop it is a kind of for vaginitis, effectively
Clear, curative for effect, Small side effects the bacteriostasis and health-care drug of substance is the task of top priority.
Summary of the invention
The present invention provides a kind of external application bacteriostatic Chinese medicinal particle and preparation method thereof, solves existing gynecological drug in background technique
Object has a single function, and material base is unclear, there are adverse reaction, there are side effect, and the problems such as effect is unobvious.
Specific technical solution is as follows:
A kind of external application bacteriostatic Chinese medicinal particle, the raw material including following parts by weight: 15-35 parts of kuh-seng, 10-20 parts of Cortex Phellodendri,
15-20 parts of wild chrysanthemum, 15-20 parts of dragon's blood, 10-20 parts of bombyx batryticatus, 10-20 parts of frutus cnidii, 5-12 parts of borneol, cornstarch 25-40
Part, 7-16 parts of chlorhexidine acetate, 40-55 parts of water, 3-8 parts of olive oil, 5-8 parts of adjuvant.
Preferably, the raw material including following parts by weight: 25 parts of kuh-seng, 15 parts of Cortex Phellodendri, 15 parts of wild chrysanthemum, 17 parts of dragon's blood,
15 parts of bombyx batryticatus, 10 parts of frutus cnidii, 7 parts of borneol, 30 parts of cornstarch, 7 parts of chlorhexidine acetate, 45 parts of water, 5 parts of olive oil, auxiliary
7 parts of agent.
Preferably, the adjuvant are as follows: the mixture of 2-acetylamino-2-deoxy-D-glucose and Galangin, wherein N- acetyl-
2-7 parts of D- Glucosamine, 3-10 parts of Galangin.
A kind of preparation method of external application bacteriostatic Chinese medicinal particle, comprising the following steps: kuh-seng, Cortex Phellodendri, frutus cnidii are cleaned and dried
It is dry, it crushes, the 4-5 times of water measured mixing is added, extracts 3-4 times, obtains extracting solution, be concentrated and dried, obtain dried object A；It takes
Wild chrysanthemum, the dragon's blood, bombyx batryticatus of corresponding number, add water to cook 4-6h, are centrifuged 20min；Supernatant is taken to carry out using adsorption resin column
Purification process first with the water washing of 1~10 times of resin column volume, then with 1~10 times of resin column volume, concentration is 50~90%
Ethanol elution, concentration, it is dry, obtain dried object B；By dried object A and dried object B and borneol, cornstarch, acetic acid chlorine oneself
Fixed, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care particle is made.
Preferably, after kuh-seng, Cortex Phellodendri, frutus cnidii being cleaned dries pulverizing, 300-500 mesh is crossed.
Preferably, when extracting to dried object A, Extracting temperature is 95-100 DEG C.
Preferably, used revolving speed is 3000-5000r/min when being centrifuged to wild chrysanthemum, dragon's blood, bombyx batryticatus.
Preferably, if the described in any item external application bacteriostasis and health-care particles of claim 1-7 are in terms of preventing and treating gynaecological imflammation
Using；The gynaecological imflammation is vaginitis.
The utility model has the advantages that
For the present invention according to vaginitis at Anttdisease Mechanism, targetedly medication is dialectical to apply under the guidance of traditional Chinese medical theory
It controls, carries out proportion prescription in conjunction with the pathogenesis and disease symptom of vaginitis, improve the permeability of blood vessel, promote blood circulation,
Enhance bacteriostasis；In the preparation, kuh-seng, Cortex Phellodendri, frutus cnidii are cleaned into drying, crushed, the 4-5 times of water measured mixing is added,
It extracts 3-4 times, obtains extracting solution, be concentrated and dried, obtain dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number, add
Water decocts centrifugation；Supernatant is taken to carry out purification process using adsorption resin column, elution, concentration are dry, obtain dried object B；It will do
Dry object A is uniformly mixed with dried object B and borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant, is crushed, is made
Finished product bacteriostasis and health-care particle uses unused preparation method according to the characteristic of different pharmaceutical, can be by effective component therein
Sufficiently extract；It can fundamentally be reconciled, be had no toxic side effect from human body, it is efficient high, it is practical；Simultaneously have it is antibacterial and
Two kinds of effects of health care.
Specific embodiment
Embodiment 1:
The external application bacteriostasis and health-care particle of the present embodiment, the raw material including following parts by weight: 15 parts of kuh-seng, 10 parts of Cortex Phellodendri,
20 parts of wild chrysanthemum, 16 parts of dragon's blood, 17 parts of bombyx batryticatus, 13 parts of frutus cnidii, 8 parts of borneol, 40 parts of cornstarch, 9 parts of chlorhexidine acetate, water
41 parts, 8 parts of olive oil, 6 parts of adjuvant.
Wherein, the raw material proportioning of adjuvant is 2 parts of 2-acetylamino-2-deoxy-D-glucose, 10 parts of Galangin.
The external application bacteriostasis and health-care particle of this implementation the preparation method is as follows: the kuh-seng of corresponding number, Cortex Phellodendri, frutus cnidii are washed
Net drying, crushes, and crosses 300 meshes, and the water mixing of 5 times of amounts is added, extracts 3 times, and Extracting temperature is 96 DEG C, obtains extracting solution, into
Row is concentrated and dried, and obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 4h, are centrifuged 20min, revolving speed
For 3500r/min；It takes supernatant to carry out purification process using adsorption resin column, first with the water washing of 1 times of resin column volume, then uses
8 times of resin column volumes, the ethanol elution that concentration is 50%, concentration, it is dry, obtain dried object B；By dried object A and dried object B with
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
Embodiment 2:
The external application bacteriostasis and health-care particle of the present embodiment, the raw material including following parts by weight: 25 parts of kuh-seng, 15 parts of Cortex Phellodendri,
15 parts of wild chrysanthemum, 17 parts of dragon's blood, 15 parts of bombyx batryticatus, 10 parts of frutus cnidii, 7 parts of borneol, 30 parts of cornstarch, 7 parts of chlorhexidine acetate, water
45 parts, 5 parts of olive oil, 7 parts of adjuvant.
Wherein, the raw material proportioning of adjuvant is 5 parts of 2-acetylamino-2-deoxy-D-glucose, 7 parts of Galangin.
The external application bacteriostasis and health-care particle of this implementation the preparation method is as follows: the kuh-seng of corresponding number, Cortex Phellodendri, frutus cnidii are washed
Net drying, crushes, and crosses 400 meshes, and the water mixing of 4 times of amounts is added, extracts 3 times, and Extracting temperature is 95 DEG C, obtains extracting solution, into
Row is concentrated and dried, and obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 4h, are centrifuged 20min, revolving speed
For 5000r/min；It takes supernatant to carry out purification process using adsorption resin column, first with the water washing of 4 times of resin column volumes, then uses
6 times of resin column volumes, the ethanol elution that concentration is 90%, concentration, it is dry, obtain dried object B；By dried object A and dried object B with
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
Embodiment 3:
The external application bacteriostasis and health-care particle of the present embodiment, the raw material including following parts by weight: 30 parts of kuh-seng, 20 parts of Cortex Phellodendri,
17 parts of wild chrysanthemum, 20 parts of dragon's blood, 16 parts of bombyx batryticatus, 15 parts of frutus cnidii, 12 parts of borneol, 25 parts of cornstarch, 16 parts of chlorhexidine acetate,
50 parts of water, 3 parts of olive oil, 5 parts of adjuvant.
Wherein, the raw material proportioning of adjuvant is 6 parts of 2-acetylamino-2-deoxy-D-glucose, 4 parts of Galangin.
The external application bacteriostasis and health-care particle of this implementation the preparation method is as follows: the kuh-seng of corresponding number, Cortex Phellodendri, frutus cnidii are washed
Net drying, crushes, and crosses 500 meshes, and the water mixing of 4 times of amounts is added, extracts 4 times, and Extracting temperature is 97 DEG C, obtains extracting solution, into
Row is concentrated and dried, and obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 5h, are centrifuged 20min, revolving speed
For 4000r/min；It takes supernatant to carry out purification process using adsorption resin column, first with the water washing of 7 times of resin column volumes, then uses
5 times of resin column volumes, the ethanol elution that concentration is 60%, concentration, it is dry, obtain dried object B；By dried object A and dried object B with
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
Embodiment 4:
The external application bacteriostasis and health-care particle of the present embodiment, the raw material including following parts by weight: 35 parts of kuh-seng, 17 parts of Cortex Phellodendri,
16 parts of wild chrysanthemum, 15 parts of dragon's blood, 20 parts of bombyx batryticatus, 20 parts of frutus cnidii, 5 parts of borneol, 27 parts of cornstarch, 10 parts of chlorhexidine acetate,
40 parts of water, 7 parts of olive oil, 8 parts of adjuvant.
Wherein, the raw material proportioning of adjuvant is 5 parts of 2-acetylamino-2-deoxy-D-glucose, 5 parts of Galangin.
The external application bacteriostasis and health-care particle of this implementation the preparation method is as follows: the kuh-seng of corresponding number, Cortex Phellodendri, frutus cnidii are washed
Net drying, crushes, and crosses 350 meshes, and the water mixing of 5 times of amounts is added, extracts 4 times, and Extracting temperature is 100 DEG C, obtains extracting solution, into
Row is concentrated and dried, and obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 6h, are centrifuged 20min, revolving speed
For 3000r/min；Supernatant is taken to carry out purification process using adsorption resin column, first with the water washing of 10 times of resin column volumes, then
It is dry with 1 times of resin column volume, the ethanol elution that concentration is 80%, concentration, obtain dried object B；By dried object A and dried object B
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
Bacteriostatic test
Test material: embodiment 1, embodiment 2, embodiment 3, embodiment 4 and comparative example 1 are (commercially available commonly to have antibacterial work
The antibacterial particle of gynaecology).For trying bacterial species: peptostreptococcus number, vagina Gartner bacterium, staphylococcus aureus.Bacterium
Culture medium: bacteria culture media is Tryptose soy broth bouillon；Preparation method are as follows: Tryptose soy gravy powder 30g, basic fine jade
The rouge 15g plus raw water 1L that reduces phlegm and internal heat that sterilizes.Inoculum: inoculum is 3% Tryptose soy meat soup 200mL.Preparation method
Are as follows: Tryptose soy gravy powder 6g adds sterilizing to reduce phlegm and internal heat raw water 200mL.Test method: using diffusion method, and every kind of antibacterial particle is with going out
The dissolution of bacterium pyrogen removal water, obtained solution.Inoculum uniform crossover is applied on the culture medium of culture dish, culture dish is placed in
In 37 DEG C of constant temperature incubator for 24 hours, each 10, culture dish for cultivating every kind of bacterium, it is respectively that 5 kinds of each 50mg of experimental solutions are uniform
Be coated on roundlet filter paper, in addition, respectively the 10 μ L capillary burette equivalent of raw water of reducing phlegm and internal heat of experimental solutions and sterilizing drip in
On roundlet filter paper.It by 3 roundlet filter papers for being stained with experimental solutions of the same race and is stained with sterilizing again and reduces phlegm and internal heat 3 roundlets of raw water
Filter paper symmetrically is attached at the middle section on culture medium, is detected on every kind of bacteria culture media.It finally will training
Feeding ware, which is placed in 37 DEG C of constant temperature incubator, to be cultivated for 24 hours, is measured antibacterial circle diameter (bacteriostatic diameter mm meter), and test is repeated 5 times, with
5 average values are antibacterial circle diameter.
As can be seen from the above table, the bacteriostasis and health-care particle being prepared by the present invention has good bacteriostasis efficacy, suppression
Bacterium loop diameter is significantly greater than comparative example, this shows the unused preparation method that the present invention is used according to the characteristic of different pharmaceutical,
Effective component therein can sufficiently be extracted, fundamentally be reconciled, had no toxic side effect from human body, efficient high, practicability
By force.
Obviously present invention specific implementation is not subject to the restrictions described above, as long as using method concept and skill of the invention
The improvement for the various unsubstantialities that art scheme carries out, or not improved the conception and technical scheme of the invention are directly applied to it
Its occasion, within that scope of the present invention.
Claims (8)
1. a kind of external application bacteriostatic Chinese medicinal particle, which is characterized in that the raw material including following parts by weight: 15-35 parts of kuh-seng, Cortex Phellodendri
10-20 parts, 15-20 parts of wild chrysanthemum, 15-20 parts of dragon's blood, 10-20 parts of bombyx batryticatus, 10-20 parts of frutus cnidii, 5-12 parts of borneol, corn shallow lake
25-40 parts of powder, 7-16 parts of chlorhexidine acetate, 40-55 parts of water, 3-8 parts of olive oil, 5-8 parts of adjuvant.
2. external application bacteriostasis and health-care particle as described in claim 1, which is characterized in that the raw material including following parts by weight: bitter
Ginseng 25 parts, 15 parts of Cortex Phellodendri, 15 parts of wild chrysanthemum, 17 parts of dragon's blood, 15 parts of bombyx batryticatus, 10 parts of frutus cnidii, 7 parts of borneol, 30 parts of cornstarch,
7 parts of chlorhexidine acetate, 45 parts of water, 5 parts of olive oil, 7 parts of adjuvant.
3. external application bacteriostasis and health-care particle as described in claim 1, which is characterized in that the adjuvant are as follows: N- acetyl-D-amino
The mixture of glucose and Galangin, wherein 2-acetylamino-2-deoxy-D-glucose 2-7 parts, 3-10 parts of Galangin.
4. a kind of preparation method of external application bacteriostatic Chinese medicinal particle, which comprises the following steps:
Kuh-seng, Cortex Phellodendri, frutus cnidii are cleaned into drying, crushed, the 4-5 times of water measured mixing is added, extracts 3-4 times, obtains extracting solution,
It is concentrated and dried, obtains dried object A；The wild chrysanthemum, dragon's blood, bombyx batryticatus for taking corresponding number add water to cook 4-6h, are centrifuged 20min；
Supernatant is taken to carry out purification process using adsorption resin column, first with the water washing of 1~10 times of resin column volume, then with 1~10 times
Resin column volume, the ethanol elution that concentration is 50~90%, concentration, it is dry, obtain dried object B；By dried object A and dried object B
And borneol, cornstarch, chlorhexidine acetate, water, olive oil, adjuvant are uniformly mixed, and crush, finished product bacteriostasis and health-care is made
Grain.
5. the preparation method of external application bacteriostasis and health-care particle as claimed in claim 4, which is characterized in that by kuh-seng, Cortex Phellodendri, cnidium monnieri
After the clean dries pulverizing of son, 300-500 mesh is crossed.
6. the preparation method of external application bacteriostasis and health-care particle as claimed in claim 4, which is characterized in that mentioned to dried object A
When taking, Extracting temperature is 95-100 DEG C.
7. the preparation method of external application bacteriostasis and health-care particle as claimed in claim 4, which is characterized in that wild chrysanthemum, dragon's blood, deadlock
Used revolving speed is 3000-5000r/min when silkworm is centrifuged.
8. such as the described in any item external application bacteriostasis and health-care particles of claim 1-7, which is characterized in that in terms of preventing and treating gynaecological imflammation
Application；The gynaecological imflammation is vaginitis.
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