CN113397016A - Preparation method of dogwood and hawthorn table tea for reducing blood sugar - Google Patents
Preparation method of dogwood and hawthorn table tea for reducing blood sugar Download PDFInfo
- Publication number
- CN113397016A CN113397016A CN202110785763.1A CN202110785763A CN113397016A CN 113397016 A CN113397016 A CN 113397016A CN 202110785763 A CN202110785763 A CN 202110785763A CN 113397016 A CN113397016 A CN 113397016A
- Authority
- CN
- China
- Prior art keywords
- dogwood
- extract
- hawthorn
- parts
- total
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000009917 Crataegus X brevipes Nutrition 0.000 title claims abstract description 70
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 title claims abstract description 70
- 235000009685 Crataegus X maligna Nutrition 0.000 title claims abstract description 70
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 title claims abstract description 70
- 235000009486 Crataegus bullatus Nutrition 0.000 title claims abstract description 70
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 title claims abstract description 70
- 235000009682 Crataegus limnophila Nutrition 0.000 title claims abstract description 70
- 235000004423 Crataegus monogyna Nutrition 0.000 title claims abstract description 70
- 235000002313 Crataegus paludosa Nutrition 0.000 title claims abstract description 70
- 235000009840 Crataegus x incaedua Nutrition 0.000 title claims abstract description 70
- 210000004369 blood Anatomy 0.000 title claims abstract description 42
- 239000008280 blood Substances 0.000 title claims abstract description 42
- 235000000346 sugar Nutrition 0.000 title claims abstract description 26
- 244000269722 Thea sinensis Species 0.000 title claims abstract 11
- 238000002360 preparation method Methods 0.000 title claims description 17
- 240000006766 Cornus mas Species 0.000 title abstract 2
- 240000000171 Crataegus monogyna Species 0.000 title abstract 2
- 239000000284 extract Substances 0.000 claims abstract description 77
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229930182470 glycoside Natural products 0.000 claims abstract description 23
- 150000002338 glycosides Chemical class 0.000 claims abstract description 23
- 150000003648 triterpenes Chemical class 0.000 claims abstract description 23
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 22
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 22
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 22
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 22
- 229960004853 betadex Drugs 0.000 claims abstract description 22
- 239000002994 raw material Substances 0.000 claims abstract description 17
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 claims abstract description 15
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims abstract description 15
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims abstract description 15
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960004999 lycopene Drugs 0.000 claims abstract description 15
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims abstract description 15
- 235000012661 lycopene Nutrition 0.000 claims abstract description 15
- 239000001751 lycopene Substances 0.000 claims abstract description 15
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims abstract description 15
- 241000209020 Cornus Species 0.000 claims description 97
- 241001092040 Crataegus Species 0.000 claims description 68
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 20
- 235000013399 edible fruits Nutrition 0.000 claims description 13
- 239000006286 aqueous extract Substances 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 235000007106 Crataegus suborbiculata Nutrition 0.000 claims description 2
- 241000073432 Crataegus suborbiculata Species 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims description 2
- 241000238631 Hexapoda Species 0.000 claims description 2
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 235000013202 a hawthorn Nutrition 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 238000000643 oven drying Methods 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 abstract description 2
- 238000009835 boiling Methods 0.000 abstract description 2
- 239000007787 solid Substances 0.000 abstract description 2
- 241001122767 Theaceae Species 0.000 description 25
- 241000700159 Rattus Species 0.000 description 20
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 14
- 239000008103 glucose Substances 0.000 description 13
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 206010012601 diabetes mellitus Diseases 0.000 description 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 235000009200 high fat diet Nutrition 0.000 description 2
- 235000021070 high sugar diet Nutrition 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000004923 pancreatic tissue Anatomy 0.000 description 2
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 208000021959 Abnormal metabolism Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229940093181 glucose injection Drugs 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 229940090044 injection Drugs 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 description 1
- 229960001243 orlistat Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a table tea for reducing blood sugar by taking hawthorn and dogwood extracts as raw materials, belonging to the technical field of solid beverages, and the raw materials mainly comprise: fructus Corni extract (fructus Corni iridoid total glycosides and fructus Corni total triterpenes), fructus crataegi water extractive solution, L-arabinose, lycopene and beta-cyclodextrin. When the product is eaten, the product is put into a cup and poured into boiling water until the product is dissolved.
Description
Technical Field
The invention belongs to the field of food processing, relates to the technical field of solid beverages, and particularly relates to a preparation method of dogwood hawthorn table tea for reducing blood sugar.
Background
Diabetes mellitus is a chronic disease characterized mainly by hyperglycemia and abnormal metabolism of sugars, lipids and proteins due to insufficient secretion of insulin. About 2.85 million diabetics are reported worldwide, and the number of diabetics is expected to rise to 4.38 million by 2030.
The literature indicates that the main hypoglycemic components of dogwood are iridoid total glycosides and total triterpene extracts of dogwood, and the aqueous extract of hawthorn has hypoglycemic effect.
With the development of urbanization, the diet level of people is higher and higher. People in sub-health state have the phenomenon of blood sugar rise after meals, and the phenomenon is also the reason for increasing the number of diabetics, so the health hidden trouble is eliminated by urgently needing a table tea for reducing the blood sugar after meals.
Therefore, a preparation method of the table tea with the effects of reducing blood sugar and blood fat is provided.
Disclosure of Invention
The invention aims to provide a preparation method of dogwood and hawthorn table tea for reducing blood sugar.
In order to achieve the purpose, the invention provides the following technical scheme:
a preparation method of dogwood fruit and hawthorn table tea for reducing blood sugar selects dogwood iridoid total glycosides, dogwood total triterpenes and hawthorn aqueous extracts, wherein the ratio of the dogwood iridoid total glycosides to the dogwood total triterpenes to the hawthorn aqueous extracts in parts by weight is 2: 2: 1.
a preparation method of dogwood and hawthorn table tea for reducing blood sugar comprises the following raw materials in parts by weight: 10-20 parts of dogwood iridoid total glycoside extract, 10-20 parts of dogwood total triterpene extract, 5-10 parts of hawthorn water extract, 1-5 parts of L-arabinose, 0.5-2 parts of lycopene and 2-8 parts of beta-cyclodextrin.
Further, the feed comprises the following raw materials in parts by weight: 10 parts of dogwood iridoid total glycoside extract, 10 parts of dogwood total triterpene extract, 5 parts of hawthorn water extract, 1 part of L-arabinose, 0.5 part of lycopene and 2 parts of beta-cyclodextrin.
Further, the feed comprises the following raw materials in parts by weight: 20 parts of dogwood iridoid total glycoside extract, 20 parts of dogwood total triterpene extract, 10 parts of hawthorn water extract, 5 parts of L-arabinose, 2 parts of lycopene and 8 parts of beta-cyclodextrin.
Further, the feed comprises the following raw materials in parts by weight: 14 parts of dogwood iridoid total glycoside extract, 14 parts of dogwood total triterpene extract, 7 parts of hawthorn water extract, 3 parts of L-arabinose, 1 part of lycopene and 8 parts of beta-cyclodextrin.
Furthermore, dogwood serving as a raw material of the dogwood iridoid total glycoside extract and the dogwood total triterpene extract and hawthorn serving as a raw material of the hawthorn water extract both adopt products without plant diseases and insect pests, and the L-arabinose, the lycopene and the beta-cyclodextrin all belong to food grade.
The invention has the technical effects and advantages that:
the raw materials of the invention are dogwood iridoid total glycoside, dogwood total triterpene and hawthorn water extract, so that the proportion of sugar-reducing components in the final table tea is increased, and the sugar-reducing effect of the table tea is enhanced.
In the invention, L-arabinose is used as a sweetening agent. The L-arabinose is a special sweetener for diabetic foods, so that the product is more suitable for people who are prone to increase blood sugar after meals. The beta-cyclodextrin and the lycopene are added, the solubility of the product is improved by the beta-cyclodextrin, no residue exists after the product is brewed by boiling water, and therefore, the utilization rate of effective substances is improved, and the effect is enhanced; the lycopene makes the product have good color, so that the water color of the product can be accepted by eaters.
Drawings
FIG. 1 is the fasting blood glucose levels of each group;
each line represents the mean ± SD (n ═ 3); the representations marked with different letters differ significantly (p < 0.05).
FIG. 2 is triglyceride levels in various groups of rats;
each line represents the mean ± SD (n ═ 3); the representations marked with different letters differ significantly (p < 0.05).
FIG. 3 is total cholesterol levels in various groups of rats;
each line represents the mean ± SD (n ═ 3); the representations marked with different letters differ significantly (p < 0.05).
Detailed Description
The present invention is described in further detail by the following examples, and it is apparent that the described examples are only a part of the examples of the present invention, and not all of the examples. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1: a preparation method of dogwood and hawthorn table tea for reducing blood sugar comprises the following steps:
(1) preparing dogwood dry fruit powder: soaking cleaned fresh fructus Corni in 50 deg.C warm water for 20min, and removing kernel of fructus Corni. Drying the pulp without the stone at 45 deg.C for 10h, and grinding the dried pulp with a grinder to obtain dry powder of Corni fructus.
(2) Preparing a total extract water solution of the dogwood alcohol extract: mixing dry dogwood fruit powder and 70-90% of aqueous ethanol solution according to the weight ratio of 1 g: and (5-8) performing reflux extraction at a ratio of mL. Filtering to obtain alcohol extract. And carrying out reduced pressure concentration on the obtained alcohol extract to obtain the total extract of the dogwood alcohol extract. Dissolving the obtained total extract of the alcohol extract of the dogwood into water to obtain the aqueous solution of the total extract of the alcohol extract of the dogwood.
(3) Extracting the dogwood iridoid total glycosides: extracting with n-butanol of the same volume, taking out the upper layer of extract, and concentrating under reduced pressure to obtain Corni fructus iridoid total glycoside.
(4) Extracting total triterpenes of dogwood: and (4) extracting the lower layer of extract liquor in the step (3) with ethyl acetate with the same volume, taking out the upper layer of extract liquor, and concentrating under reduced pressure to obtain the dogwood total triterpene.
(5) Preparing dry hawthorn fruit powder: cleaning fresh fructus crataegi, and removing core. Removing core, baking pulp at 45 deg.C for 10 hr, and grinding with pulverizer to obtain dried fructus crataegi powder.
(6) Preparing a hawthorn aqueous solution total extract: mixing dry hawthorn fruit powder and 70-90 ℃ aqueous solution according to the weight ratio of 1 g: reflux extraction is carried out according to the proportion of (8-12 mL). And carrying out reduced pressure concentration on the obtained water solution to obtain the hawthorn water extract total extract.
(7) Preparing dogwood and hawthorn table tea: mixing dogwood total triterpenes, dogwood iridoid total glycosides and hawthorn aqueous extracts according to a weight ratio of 2: 2: 1, uniformly mixing and preparing a mixed material. Adding L-arabinose, beta-cyclodextrin and lycopene into the mixture. And then spray drying the solution to obtain the dogwood hawthorn table tea for reducing blood sugar.
Example 2: tests for lowering blood sugar, triglyceride and total cholesterol
First, experiment method
1. Preparation of pharmaceutical products
Preparing dogwood hawthorn table tea according to the method in example 1, preparing dogwood alcohol extract according to the step (2) in example 1, preparing hawthorn water extract according to the step (6) in example 1, pulverizing dogwood and hawthorn into dry powder, and then mixing the dry powder according to the ratio of 2: 1, preparing dogwood hawthorn dry powder, and preparing the dogwood hawthorn table tea without beta-cyclodextrin according to the method in the example 1.
2. Establishment of diabetes model
The purchased 72 male Kunming rats were weighed after acclimation for 3 days and randomly divided into 8 groups and 9 groups per group according to the weight. The rats except the normal group were molded. The normal group of rats 9 were housed in one cage, and the model rats 63 were housed in 7 cages. The normal group was fed with normal diet, and the model group was fed with high-sugar and high-fat diet.
After 2 weeks of feeding, the normal group and the model group were fasted for 12 hours (free drinking water), and then the model group was intraperitoneally injected with streptozotocin (STZ, 50mg/kg), and the model group rats were injected with an equal amount of 0.9% physiological saline. One week after injection, fasted for 12h (free access to water) and glucose (2g/kg) was taken orally. Blood samples were taken from the tail tips of rats 0min and 120min after the glucose injection and blood glucose levels were measured with a glucometer. Rats with 0min blood glucose level ≥ 7.8mmol/L or 120min blood glucose level ≥ 11.1mmol/L are considered type 2 diabetic rats.
3. Animal grouping, administration and sample collection
Three normal rats were set as normal control group (NC), 63 molded rats were randomly divided into 7 groups, i.e., diabetes model group (T2DM), dogwood alcohol extract group (DOG), hawthorn water extract group (HAW), dogwood hawthorn dry powder group (D + H (dp)), dogwood hawthorn table tea group (D + H (N β)) without β -cyclodextrin, dogwood hawthorn table tea group (D + H), and positive control group (ORL). Dog, HAW, D + H (DP), D + H (Nbeta), D + H and ORL are respectively given 100mg/kg body weight of dogwood alcohol extract, hawthorn water extract, dogwood hawthorn dry powder, dogwood hawthorn table tea without beta-cyclodextrin, dogwood hawthorn table tea and orlistat, NC and T2DM groups are given 0.9% physiological saline with the same amount, and the stomach is perfused for 2 times a day for 14 days continuously. After weighing, the experimental animals were sacrificed and blood and pancreatic tissue samples were collected. The serum was separated from the blood sample by centrifugation at 300g for 10min at 4 ℃ and stored at-20 ℃ until further analysis. And the remaining pancreatic tissue was thoroughly washed in 0.9% cold physiological saline, then frozen in liquid nitrogen and stored at-80 ℃ for biochemical analysis.
4. Detecting the index
1) Serum Triglyceride (TG) and Total Cholesterol (TC) assays
Serum TG and TC levels were determined spectrophotometrically using a commercial diagnostic kit (tokyo institute of biotechnology).
2) Blood glucose level determination
Blood glucose levels were determined 2 weeks after feeding with the corresponding drugs, while feeding with high-sugar and high-fat diet. Rats were fasted overnight before blood glucose levels were determined. Blood was taken from the tip of the tail vein of the rat, and the blood glucose level was measured with a glucometer.
Second, statistical analysis
All experimental data are expressed as mean ± SD. In all experiments, the significant difference from the respective controls was assessed by one-way analysis of variance (ANOVA) of SPSS (IBM Corporation, Chicago, IL, USA). p <0.05 is considered statistically significant.
Third, experimental results
1) The dogwood hawthorn table tea can obviously reduce fasting blood glucose of rats with diabetes
The fasting blood sugar of the rats in the NC group is 4.08 +/-0.14 mmol/L, and the fasting blood sugar of the rats in the T2DM group is 34.19 +/-0.07 mmol/L. The alcohol extract of dogwood, the aqueous extract of hawthorn, the dry powder of dogwood and hawthorn, the dogwood and hawthorn table tea without beta-cyclodextrin and the dogwood and hawthorn table tea can obviously reduce the fasting blood glucose level of rats with type 2 diabetes. Respectively 16.23 +/-0.08, 21.47 +/-0.05, 13.31 +/-0.06, 9.14 +/-0.09 and 5.32 +/-0.09 mmol/L. And the result shows that the fasting blood glucose value measured by the dogwood hawthorn table tea group added with the beta-cyclodextrin in the treatment group is the lowest, and then the blood glucose values are sequentially from low to high: the dogwood hawthorn fruit table tea group, the dogwood hawthorn fruit dry powder group, the dogwood alcohol extract group and the hawthorn fruit water extract group are free of beta-cyclodextrin. (p < 0.05).
2) The dogwood hawthorn table tea can obviously reduce triglyceride and total cholesterol levels of rats with diabetes
TG and TC levels were significantly increased in the T2DM group compared to the NC group. TG levels were reduced 137.52%, 116.33%, 170.43, 208.55% and 244.78% in DOG group, HAW group, D + H (dp), D + H (D β) and D + H group, respectively, compared to T2DM group. The TC levels were reduced by 210.82%, 152.91%, 260.43%, 339.37% and 484.57% in the DOG group, the HAW group, the D + H (dp), the D + H (D β) and the D + H group, respectively, compared to the T2DM group and the T2DM group. And the results show that the capacity of the dogwood hawthorn table tea group added with beta-cyclodextrin for reducing the TG and TC levels of diabetic rats is obviously higher than that of dogwood alcohol extract, hawthorn water extract, dogwood hawthorn dry powder and beta-cyclodextrin-free (p is less than 0.05).
Claims (8)
1. A preparation method of dogwood fruit and hawthorn table tea for reducing blood sugar is characterized by comprising the following raw materials: comprises Corni fructus iridoid total glycoside, Corni fructus total triterpene and fructus crataegi water extract; the weight ratio of the dogwood iridoid total glycosides to the dogwood total triterpenes to the hawthorn aqueous extract is 2: 2: 1;
preparing the three raw materials into a mixed material, adding L-arabinose, beta-cyclodextrin and lycopene into the mixed material, dissolving the mixture into normal-temperature water, and then performing spray drying on the solution to obtain the dogwood hawthorn table tea for reducing blood sugar.
2. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 10-20 parts of dogwood iridoid total glycoside extract, 10-20 parts of dogwood total triterpene extract, 5-10 parts of hawthorn water extract, 1-5 parts of L-arabinose, 0.5-2 parts of lycopene and 2-8 parts of beta-cyclodextrin.
3. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following steps: the composition is characterized by comprising the following raw materials in parts by weight: 10 parts of dogwood iridoid total glycoside extract, 10 parts of dogwood total triterpene extract, 5 parts of hawthorn water extract, 1 part of L-arabinose, 0.5 part of lycopene and 2 parts of beta-cyclodextrin.
4. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following steps: the feed comprises the following raw materials in parts by weight: 20 parts of dogwood iridoid total glycoside extract, 20 parts of dogwood total triterpene extract, 10 parts of hawthorn water extract, 5 parts of L-arabinose, 2 parts of lycopene and 8 parts of beta-cyclodextrin.
5. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following steps: the feed comprises the following raw materials in parts by weight: 14 parts of dogwood iridoid total glycoside extract, 14 parts of dogwood total triterpene extract, 7 parts of hawthorn water extract, 3 parts of L-arabinose, 1 part of lycopene and 8 parts of beta-cyclodextrin.
6. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following steps: the dogwood iridoid total glycoside extract, the raw material dogwood of the dogwood total triterpene extract and the raw material hawthorn of the hawthorn water extract all adopt products without plant diseases and insect pests, and the L-arabinose, the lycopene and the beta-cyclodextrin all belong to food grade.
7. The preparation method of the dogwood hawthorn table tea for reducing blood sugar according to any one of claims 1 to 6, which is characterized by comprising the following steps: the dogwood iridoid total glycosides and dogwood total triterpenes are obtained by the following method:
(1) preparing dogwood dry fruit powder: soaking cleaned fresh fructus Corni in 50 deg.C warm water for 20min, removing kernel of fructus Corni, oven drying the kernel-removed pulp at 45 deg.C for 10 hr, and grinding the oven dried pulp with a grinder to obtain dried fructus Corni powder;
(2) preparing a total extract water solution of the dogwood alcohol extract: mixing dry dogwood fruit powder and 70-90% of aqueous ethanol solution according to the weight ratio of 1 g: and (5-8) mL, carrying out reflux extraction, filtering to obtain an alcohol extract, and carrying out reduced pressure concentration on the obtained alcohol extract to obtain the total extract of the dogwood alcohol extract. Dissolving the obtained total extract of the alcohol extract of the dogwood into water to obtain the water solution of the total extract of the alcohol extract of the dogwood;
(3) extracting the dogwood iridoid total glycosides: extracting with n-butanol of the same volume, taking out the upper layer of extract, and concentrating under reduced pressure to obtain Corni fructus iridoid total glycoside;
(4) extracting total triterpenes of dogwood: and (4) extracting the lower layer of extract liquor in the step (3) with ethyl acetate with the same volume, taking out the upper layer of extract liquor, and concentrating under reduced pressure to obtain the dogwood total triterpene.
8. The preparation method of the dogwood hawthorn table tea for reducing blood sugar according to any one of claims 1 to 6, which is characterized by comprising the following steps: the hawthorn aqueous extract is obtained by the following method:
(1) preparing dry hawthorn fruit powder: cleaning fresh fructus crataegi, and removing core. Removing core, baking pulp at 45 deg.C for 10 hr, and grinding with pulverizer to obtain dried fructus crataegi powder.
(2) Preparing a hawthorn aqueous solution total extract: mixing dry hawthorn fruit powder and 70-90 ℃ aqueous solution according to the weight ratio of 1 g: (8-12 mL), and carrying out reflux extraction on the obtained aqueous solution, and carrying out reduced pressure concentration on the obtained aqueous solution to obtain the hawthorn aqueous extract total extract.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110785763.1A CN113397016B (en) | 2021-07-12 | 2021-07-12 | Preparation method of dogwood and hawthorn table tea for reducing blood sugar |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110785763.1A CN113397016B (en) | 2021-07-12 | 2021-07-12 | Preparation method of dogwood and hawthorn table tea for reducing blood sugar |
Publications (2)
Publication Number | Publication Date |
---|---|
CN113397016A true CN113397016A (en) | 2021-09-17 |
CN113397016B CN113397016B (en) | 2022-08-02 |
Family
ID=77685964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110785763.1A Active CN113397016B (en) | 2021-07-12 | 2021-07-12 | Preparation method of dogwood and hawthorn table tea for reducing blood sugar |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN113397016B (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1270830A (en) * | 1999-04-19 | 2000-10-25 | 郭立文 | Sanjiangcha tea for reducing blood sugar, blood pressure and blood lipoid and its preparation |
US20010002269A1 (en) * | 1997-05-06 | 2001-05-31 | Zhao Iris Ginron | Multi-phase food & beverage |
CN102047990A (en) * | 2010-09-29 | 2011-05-11 | 吴肖慧 | Traditional Chinese medicine health care tea for preventing and treating hyperlipidaemia |
CN103734424A (en) * | 2013-12-30 | 2014-04-23 | 青岛恒波仪器有限公司 | Tartary buckwheat tea capable of losing weight, reducing lipid and relaxing bowels, and preparation method of tea |
CN105124078A (en) * | 2015-10-12 | 2015-12-09 | 青岛恒波仪器有限公司 | Gardenia blood-glucose-reducing and lipid-reducing healthcare tea and preparing method thereof |
CN106473099A (en) * | 2016-10-12 | 2017-03-08 | 钟术光 | Functional food or alternative tea that effect improves |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU189162B (en) * | 1982-08-03 | 1986-06-30 | Balogh,Gyula,Hu | Process for the production of tea against fatness |
-
2021
- 2021-07-12 CN CN202110785763.1A patent/CN113397016B/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010002269A1 (en) * | 1997-05-06 | 2001-05-31 | Zhao Iris Ginron | Multi-phase food & beverage |
CN1270830A (en) * | 1999-04-19 | 2000-10-25 | 郭立文 | Sanjiangcha tea for reducing blood sugar, blood pressure and blood lipoid and its preparation |
CN102047990A (en) * | 2010-09-29 | 2011-05-11 | 吴肖慧 | Traditional Chinese medicine health care tea for preventing and treating hyperlipidaemia |
CN103734424A (en) * | 2013-12-30 | 2014-04-23 | 青岛恒波仪器有限公司 | Tartary buckwheat tea capable of losing weight, reducing lipid and relaxing bowels, and preparation method of tea |
CN105124078A (en) * | 2015-10-12 | 2015-12-09 | 青岛恒波仪器有限公司 | Gardenia blood-glucose-reducing and lipid-reducing healthcare tea and preparing method thereof |
CN106473099A (en) * | 2016-10-12 | 2017-03-08 | 钟术光 | Functional food or alternative tea that effect improves |
Non-Patent Citations (5)
Title |
---|
李慧敏 等: "山茱萸降血糖作用研究进展", 《中药材》 * |
李观林: "山茱萸中环烯醚萜苷类的研究进展", 《亚太传统医药》 * |
苏鹏超 等: "UPLC法测定不同产地山茱萸中6种成分含量", 《陕西理工大学学报(自然科学版)》 * |
赵艳艳 等: "山茱萸环烯醚萜总苷降血糖研究进展", 《陕西农业科学》 * |
钟丽霞 等: "山楂多糖提取工艺优化及其降血糖、降血脂活性", 《食品工业科技》 * |
Also Published As
Publication number | Publication date |
---|---|
CN113397016B (en) | 2022-08-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100956278B1 (en) | Composition comprising an extract of herbal combination thereof for preventing and treating diabetes mellitus | |
CN109527540A (en) | A kind of preparation method of sea-buckthorn antihypelipidemic foodstuff | |
CN1299742C (en) | Medicine for treating diabetes, and its prepn. method | |
KR20160007728A (en) | Method for manufacturing garlic skin extract and food composition for preventing and alleviating diabetes prepared using the same | |
CN110624042B (en) | Composition for treating diabetic diseases | |
KR20080018676A (en) | Anti-diabetic food composition comprising extracts from natural herbal materials and propolis and process for preparing the same | |
WO1999025197A1 (en) | Fenugreek compositions having reduced taste and odor and methods of use | |
CN102448479B (en) | A novel antidiabetic furostanolic saponin rich (fsr) fraction from fenugreek seeds | |
CN105795292A (en) | Drink containing corn stigma and ginseng and preparation method of drink | |
KR20120021864A (en) | Antidiabetic composition comprising plants extract mixture | |
CN102813112B (en) | Foodstuff for diabetic nephropathy | |
CN113397016B (en) | Preparation method of dogwood and hawthorn table tea for reducing blood sugar | |
CN111450136A (en) | Oyster and kudzu root composite particles and preparation method thereof | |
CN107136512A (en) | A kind of vinegar capsule of auxiliary hyperglycemic reducing blood lipid and preparation method thereof | |
CN100484539C (en) | Functional food with blood sugar reducing action and its preparing method | |
JP2003171303A (en) | Composition comprising specific plant, and medicine and food for health use comprising the same composition as active ingredient | |
CN107260946A (en) | A kind of health-care edible capsule preparation method with auxiliary hyperglycemic function | |
Viado et al. | Anti-diabetic effects of Hibiscus spp. extract in rat and mice models: a review | |
JP2007520548A (en) | Composition for prevention and treatment of diabetic complications | |
KR20100111088A (en) | Composition for preventing and treating diabetes mellitus or diabetic complications comprising extract of herbal combination | |
CN106942439B (en) | Cyclocarya paliurus and guava leaf blood glucose reducing tea and preparation method and application thereof | |
CN108077171A (en) | A kind of cultural method of reed catkins chicken | |
CN107821538A (en) | A kind of hypoglycemic biscuit and preparation method thereof | |
CN114916597B (en) | Tea therapy composition for treating type 2 diabetes | |
CN108543002B (en) | Mulberry grass hypoglycemic tablets and preparation process thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |