CN113397016A - Preparation method of dogwood and hawthorn table tea for reducing blood sugar - Google Patents

Preparation method of dogwood and hawthorn table tea for reducing blood sugar Download PDF

Info

Publication number
CN113397016A
CN113397016A CN202110785763.1A CN202110785763A CN113397016A CN 113397016 A CN113397016 A CN 113397016A CN 202110785763 A CN202110785763 A CN 202110785763A CN 113397016 A CN113397016 A CN 113397016A
Authority
CN
China
Prior art keywords
dogwood
extract
hawthorn
parts
total
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202110785763.1A
Other languages
Chinese (zh)
Other versions
CN113397016B (en
Inventor
张小莺
张逍遥
李奔
周锋
陈琛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shaanxi University of Technology
Original Assignee
Shaanxi University of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shaanxi University of Technology filed Critical Shaanxi University of Technology
Priority to CN202110785763.1A priority Critical patent/CN113397016B/en
Publication of CN113397016A publication Critical patent/CN113397016A/en
Application granted granted Critical
Publication of CN113397016B publication Critical patent/CN113397016B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention discloses a table tea for reducing blood sugar by taking hawthorn and dogwood extracts as raw materials, belonging to the technical field of solid beverages, and the raw materials mainly comprise: fructus Corni extract (fructus Corni iridoid total glycosides and fructus Corni total triterpenes), fructus crataegi water extractive solution, L-arabinose, lycopene and beta-cyclodextrin. When the product is eaten, the product is put into a cup and poured into boiling water until the product is dissolved.

Description

Preparation method of dogwood and hawthorn table tea for reducing blood sugar
Technical Field
The invention belongs to the field of food processing, relates to the technical field of solid beverages, and particularly relates to a preparation method of dogwood hawthorn table tea for reducing blood sugar.
Background
Diabetes mellitus is a chronic disease characterized mainly by hyperglycemia and abnormal metabolism of sugars, lipids and proteins due to insufficient secretion of insulin. About 2.85 million diabetics are reported worldwide, and the number of diabetics is expected to rise to 4.38 million by 2030.
The literature indicates that the main hypoglycemic components of dogwood are iridoid total glycosides and total triterpene extracts of dogwood, and the aqueous extract of hawthorn has hypoglycemic effect.
With the development of urbanization, the diet level of people is higher and higher. People in sub-health state have the phenomenon of blood sugar rise after meals, and the phenomenon is also the reason for increasing the number of diabetics, so the health hidden trouble is eliminated by urgently needing a table tea for reducing the blood sugar after meals.
Therefore, a preparation method of the table tea with the effects of reducing blood sugar and blood fat is provided.
Disclosure of Invention
The invention aims to provide a preparation method of dogwood and hawthorn table tea for reducing blood sugar.
In order to achieve the purpose, the invention provides the following technical scheme:
a preparation method of dogwood fruit and hawthorn table tea for reducing blood sugar selects dogwood iridoid total glycosides, dogwood total triterpenes and hawthorn aqueous extracts, wherein the ratio of the dogwood iridoid total glycosides to the dogwood total triterpenes to the hawthorn aqueous extracts in parts by weight is 2: 2: 1.
a preparation method of dogwood and hawthorn table tea for reducing blood sugar comprises the following raw materials in parts by weight: 10-20 parts of dogwood iridoid total glycoside extract, 10-20 parts of dogwood total triterpene extract, 5-10 parts of hawthorn water extract, 1-5 parts of L-arabinose, 0.5-2 parts of lycopene and 2-8 parts of beta-cyclodextrin.
Further, the feed comprises the following raw materials in parts by weight: 10 parts of dogwood iridoid total glycoside extract, 10 parts of dogwood total triterpene extract, 5 parts of hawthorn water extract, 1 part of L-arabinose, 0.5 part of lycopene and 2 parts of beta-cyclodextrin.
Further, the feed comprises the following raw materials in parts by weight: 20 parts of dogwood iridoid total glycoside extract, 20 parts of dogwood total triterpene extract, 10 parts of hawthorn water extract, 5 parts of L-arabinose, 2 parts of lycopene and 8 parts of beta-cyclodextrin.
Further, the feed comprises the following raw materials in parts by weight: 14 parts of dogwood iridoid total glycoside extract, 14 parts of dogwood total triterpene extract, 7 parts of hawthorn water extract, 3 parts of L-arabinose, 1 part of lycopene and 8 parts of beta-cyclodextrin.
Furthermore, dogwood serving as a raw material of the dogwood iridoid total glycoside extract and the dogwood total triterpene extract and hawthorn serving as a raw material of the hawthorn water extract both adopt products without plant diseases and insect pests, and the L-arabinose, the lycopene and the beta-cyclodextrin all belong to food grade.
The invention has the technical effects and advantages that:
the raw materials of the invention are dogwood iridoid total glycoside, dogwood total triterpene and hawthorn water extract, so that the proportion of sugar-reducing components in the final table tea is increased, and the sugar-reducing effect of the table tea is enhanced.
In the invention, L-arabinose is used as a sweetening agent. The L-arabinose is a special sweetener for diabetic foods, so that the product is more suitable for people who are prone to increase blood sugar after meals. The beta-cyclodextrin and the lycopene are added, the solubility of the product is improved by the beta-cyclodextrin, no residue exists after the product is brewed by boiling water, and therefore, the utilization rate of effective substances is improved, and the effect is enhanced; the lycopene makes the product have good color, so that the water color of the product can be accepted by eaters.
Drawings
FIG. 1 is the fasting blood glucose levels of each group;
each line represents the mean ± SD (n ═ 3); the representations marked with different letters differ significantly (p < 0.05).
FIG. 2 is triglyceride levels in various groups of rats;
each line represents the mean ± SD (n ═ 3); the representations marked with different letters differ significantly (p < 0.05).
FIG. 3 is total cholesterol levels in various groups of rats;
each line represents the mean ± SD (n ═ 3); the representations marked with different letters differ significantly (p < 0.05).
Detailed Description
The present invention is described in further detail by the following examples, and it is apparent that the described examples are only a part of the examples of the present invention, and not all of the examples. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1: a preparation method of dogwood and hawthorn table tea for reducing blood sugar comprises the following steps:
(1) preparing dogwood dry fruit powder: soaking cleaned fresh fructus Corni in 50 deg.C warm water for 20min, and removing kernel of fructus Corni. Drying the pulp without the stone at 45 deg.C for 10h, and grinding the dried pulp with a grinder to obtain dry powder of Corni fructus.
(2) Preparing a total extract water solution of the dogwood alcohol extract: mixing dry dogwood fruit powder and 70-90% of aqueous ethanol solution according to the weight ratio of 1 g: and (5-8) performing reflux extraction at a ratio of mL. Filtering to obtain alcohol extract. And carrying out reduced pressure concentration on the obtained alcohol extract to obtain the total extract of the dogwood alcohol extract. Dissolving the obtained total extract of the alcohol extract of the dogwood into water to obtain the aqueous solution of the total extract of the alcohol extract of the dogwood.
(3) Extracting the dogwood iridoid total glycosides: extracting with n-butanol of the same volume, taking out the upper layer of extract, and concentrating under reduced pressure to obtain Corni fructus iridoid total glycoside.
(4) Extracting total triterpenes of dogwood: and (4) extracting the lower layer of extract liquor in the step (3) with ethyl acetate with the same volume, taking out the upper layer of extract liquor, and concentrating under reduced pressure to obtain the dogwood total triterpene.
(5) Preparing dry hawthorn fruit powder: cleaning fresh fructus crataegi, and removing core. Removing core, baking pulp at 45 deg.C for 10 hr, and grinding with pulverizer to obtain dried fructus crataegi powder.
(6) Preparing a hawthorn aqueous solution total extract: mixing dry hawthorn fruit powder and 70-90 ℃ aqueous solution according to the weight ratio of 1 g: reflux extraction is carried out according to the proportion of (8-12 mL). And carrying out reduced pressure concentration on the obtained water solution to obtain the hawthorn water extract total extract.
(7) Preparing dogwood and hawthorn table tea: mixing dogwood total triterpenes, dogwood iridoid total glycosides and hawthorn aqueous extracts according to a weight ratio of 2: 2: 1, uniformly mixing and preparing a mixed material. Adding L-arabinose, beta-cyclodextrin and lycopene into the mixture. And then spray drying the solution to obtain the dogwood hawthorn table tea for reducing blood sugar.
Example 2: tests for lowering blood sugar, triglyceride and total cholesterol
First, experiment method
1. Preparation of pharmaceutical products
Preparing dogwood hawthorn table tea according to the method in example 1, preparing dogwood alcohol extract according to the step (2) in example 1, preparing hawthorn water extract according to the step (6) in example 1, pulverizing dogwood and hawthorn into dry powder, and then mixing the dry powder according to the ratio of 2: 1, preparing dogwood hawthorn dry powder, and preparing the dogwood hawthorn table tea without beta-cyclodextrin according to the method in the example 1.
2. Establishment of diabetes model
The purchased 72 male Kunming rats were weighed after acclimation for 3 days and randomly divided into 8 groups and 9 groups per group according to the weight. The rats except the normal group were molded. The normal group of rats 9 were housed in one cage, and the model rats 63 were housed in 7 cages. The normal group was fed with normal diet, and the model group was fed with high-sugar and high-fat diet.
After 2 weeks of feeding, the normal group and the model group were fasted for 12 hours (free drinking water), and then the model group was intraperitoneally injected with streptozotocin (STZ, 50mg/kg), and the model group rats were injected with an equal amount of 0.9% physiological saline. One week after injection, fasted for 12h (free access to water) and glucose (2g/kg) was taken orally. Blood samples were taken from the tail tips of rats 0min and 120min after the glucose injection and blood glucose levels were measured with a glucometer. Rats with 0min blood glucose level ≥ 7.8mmol/L or 120min blood glucose level ≥ 11.1mmol/L are considered type 2 diabetic rats.
3. Animal grouping, administration and sample collection
Three normal rats were set as normal control group (NC), 63 molded rats were randomly divided into 7 groups, i.e., diabetes model group (T2DM), dogwood alcohol extract group (DOG), hawthorn water extract group (HAW), dogwood hawthorn dry powder group (D + H (dp)), dogwood hawthorn table tea group (D + H (N β)) without β -cyclodextrin, dogwood hawthorn table tea group (D + H), and positive control group (ORL). Dog, HAW, D + H (DP), D + H (Nbeta), D + H and ORL are respectively given 100mg/kg body weight of dogwood alcohol extract, hawthorn water extract, dogwood hawthorn dry powder, dogwood hawthorn table tea without beta-cyclodextrin, dogwood hawthorn table tea and orlistat, NC and T2DM groups are given 0.9% physiological saline with the same amount, and the stomach is perfused for 2 times a day for 14 days continuously. After weighing, the experimental animals were sacrificed and blood and pancreatic tissue samples were collected. The serum was separated from the blood sample by centrifugation at 300g for 10min at 4 ℃ and stored at-20 ℃ until further analysis. And the remaining pancreatic tissue was thoroughly washed in 0.9% cold physiological saline, then frozen in liquid nitrogen and stored at-80 ℃ for biochemical analysis.
4. Detecting the index
1) Serum Triglyceride (TG) and Total Cholesterol (TC) assays
Serum TG and TC levels were determined spectrophotometrically using a commercial diagnostic kit (tokyo institute of biotechnology).
2) Blood glucose level determination
Blood glucose levels were determined 2 weeks after feeding with the corresponding drugs, while feeding with high-sugar and high-fat diet. Rats were fasted overnight before blood glucose levels were determined. Blood was taken from the tip of the tail vein of the rat, and the blood glucose level was measured with a glucometer.
Second, statistical analysis
All experimental data are expressed as mean ± SD. In all experiments, the significant difference from the respective controls was assessed by one-way analysis of variance (ANOVA) of SPSS (IBM Corporation, Chicago, IL, USA). p <0.05 is considered statistically significant.
Third, experimental results
1) The dogwood hawthorn table tea can obviously reduce fasting blood glucose of rats with diabetes
The fasting blood sugar of the rats in the NC group is 4.08 +/-0.14 mmol/L, and the fasting blood sugar of the rats in the T2DM group is 34.19 +/-0.07 mmol/L. The alcohol extract of dogwood, the aqueous extract of hawthorn, the dry powder of dogwood and hawthorn, the dogwood and hawthorn table tea without beta-cyclodextrin and the dogwood and hawthorn table tea can obviously reduce the fasting blood glucose level of rats with type 2 diabetes. Respectively 16.23 +/-0.08, 21.47 +/-0.05, 13.31 +/-0.06, 9.14 +/-0.09 and 5.32 +/-0.09 mmol/L. And the result shows that the fasting blood glucose value measured by the dogwood hawthorn table tea group added with the beta-cyclodextrin in the treatment group is the lowest, and then the blood glucose values are sequentially from low to high: the dogwood hawthorn fruit table tea group, the dogwood hawthorn fruit dry powder group, the dogwood alcohol extract group and the hawthorn fruit water extract group are free of beta-cyclodextrin. (p < 0.05).
2) The dogwood hawthorn table tea can obviously reduce triglyceride and total cholesterol levels of rats with diabetes
TG and TC levels were significantly increased in the T2DM group compared to the NC group. TG levels were reduced 137.52%, 116.33%, 170.43, 208.55% and 244.78% in DOG group, HAW group, D + H (dp), D + H (D β) and D + H group, respectively, compared to T2DM group. The TC levels were reduced by 210.82%, 152.91%, 260.43%, 339.37% and 484.57% in the DOG group, the HAW group, the D + H (dp), the D + H (D β) and the D + H group, respectively, compared to the T2DM group and the T2DM group. And the results show that the capacity of the dogwood hawthorn table tea group added with beta-cyclodextrin for reducing the TG and TC levels of diabetic rats is obviously higher than that of dogwood alcohol extract, hawthorn water extract, dogwood hawthorn dry powder and beta-cyclodextrin-free (p is less than 0.05).

Claims (8)

1. A preparation method of dogwood fruit and hawthorn table tea for reducing blood sugar is characterized by comprising the following raw materials: comprises Corni fructus iridoid total glycoside, Corni fructus total triterpene and fructus crataegi water extract; the weight ratio of the dogwood iridoid total glycosides to the dogwood total triterpenes to the hawthorn aqueous extract is 2: 2: 1;
preparing the three raw materials into a mixed material, adding L-arabinose, beta-cyclodextrin and lycopene into the mixed material, dissolving the mixture into normal-temperature water, and then performing spray drying on the solution to obtain the dogwood hawthorn table tea for reducing blood sugar.
2. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 10-20 parts of dogwood iridoid total glycoside extract, 10-20 parts of dogwood total triterpene extract, 5-10 parts of hawthorn water extract, 1-5 parts of L-arabinose, 0.5-2 parts of lycopene and 2-8 parts of beta-cyclodextrin.
3. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following steps: the composition is characterized by comprising the following raw materials in parts by weight: 10 parts of dogwood iridoid total glycoside extract, 10 parts of dogwood total triterpene extract, 5 parts of hawthorn water extract, 1 part of L-arabinose, 0.5 part of lycopene and 2 parts of beta-cyclodextrin.
4. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following steps: the feed comprises the following raw materials in parts by weight: 20 parts of dogwood iridoid total glycoside extract, 20 parts of dogwood total triterpene extract, 10 parts of hawthorn water extract, 5 parts of L-arabinose, 2 parts of lycopene and 8 parts of beta-cyclodextrin.
5. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following steps: the feed comprises the following raw materials in parts by weight: 14 parts of dogwood iridoid total glycoside extract, 14 parts of dogwood total triterpene extract, 7 parts of hawthorn water extract, 3 parts of L-arabinose, 1 part of lycopene and 8 parts of beta-cyclodextrin.
6. The preparation method of dogwood and hawthorn table tea for reducing blood sugar according to claim 1, which is characterized by comprising the following steps: the dogwood iridoid total glycoside extract, the raw material dogwood of the dogwood total triterpene extract and the raw material hawthorn of the hawthorn water extract all adopt products without plant diseases and insect pests, and the L-arabinose, the lycopene and the beta-cyclodextrin all belong to food grade.
7. The preparation method of the dogwood hawthorn table tea for reducing blood sugar according to any one of claims 1 to 6, which is characterized by comprising the following steps: the dogwood iridoid total glycosides and dogwood total triterpenes are obtained by the following method:
(1) preparing dogwood dry fruit powder: soaking cleaned fresh fructus Corni in 50 deg.C warm water for 20min, removing kernel of fructus Corni, oven drying the kernel-removed pulp at 45 deg.C for 10 hr, and grinding the oven dried pulp with a grinder to obtain dried fructus Corni powder;
(2) preparing a total extract water solution of the dogwood alcohol extract: mixing dry dogwood fruit powder and 70-90% of aqueous ethanol solution according to the weight ratio of 1 g: and (5-8) mL, carrying out reflux extraction, filtering to obtain an alcohol extract, and carrying out reduced pressure concentration on the obtained alcohol extract to obtain the total extract of the dogwood alcohol extract. Dissolving the obtained total extract of the alcohol extract of the dogwood into water to obtain the water solution of the total extract of the alcohol extract of the dogwood;
(3) extracting the dogwood iridoid total glycosides: extracting with n-butanol of the same volume, taking out the upper layer of extract, and concentrating under reduced pressure to obtain Corni fructus iridoid total glycoside;
(4) extracting total triterpenes of dogwood: and (4) extracting the lower layer of extract liquor in the step (3) with ethyl acetate with the same volume, taking out the upper layer of extract liquor, and concentrating under reduced pressure to obtain the dogwood total triterpene.
8. The preparation method of the dogwood hawthorn table tea for reducing blood sugar according to any one of claims 1 to 6, which is characterized by comprising the following steps: the hawthorn aqueous extract is obtained by the following method:
(1) preparing dry hawthorn fruit powder: cleaning fresh fructus crataegi, and removing core. Removing core, baking pulp at 45 deg.C for 10 hr, and grinding with pulverizer to obtain dried fructus crataegi powder.
(2) Preparing a hawthorn aqueous solution total extract: mixing dry hawthorn fruit powder and 70-90 ℃ aqueous solution according to the weight ratio of 1 g: (8-12 mL), and carrying out reflux extraction on the obtained aqueous solution, and carrying out reduced pressure concentration on the obtained aqueous solution to obtain the hawthorn aqueous extract total extract.
CN202110785763.1A 2021-07-12 2021-07-12 Preparation method of dogwood and hawthorn table tea for reducing blood sugar Active CN113397016B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110785763.1A CN113397016B (en) 2021-07-12 2021-07-12 Preparation method of dogwood and hawthorn table tea for reducing blood sugar

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110785763.1A CN113397016B (en) 2021-07-12 2021-07-12 Preparation method of dogwood and hawthorn table tea for reducing blood sugar

Publications (2)

Publication Number Publication Date
CN113397016A true CN113397016A (en) 2021-09-17
CN113397016B CN113397016B (en) 2022-08-02

Family

ID=77685964

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110785763.1A Active CN113397016B (en) 2021-07-12 2021-07-12 Preparation method of dogwood and hawthorn table tea for reducing blood sugar

Country Status (1)

Country Link
CN (1) CN113397016B (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1270830A (en) * 1999-04-19 2000-10-25 郭立文 Sanjiangcha tea for reducing blood sugar, blood pressure and blood lipoid and its preparation
US20010002269A1 (en) * 1997-05-06 2001-05-31 Zhao Iris Ginron Multi-phase food & beverage
CN102047990A (en) * 2010-09-29 2011-05-11 吴肖慧 Traditional Chinese medicine health care tea for preventing and treating hyperlipidaemia
CN103734424A (en) * 2013-12-30 2014-04-23 青岛恒波仪器有限公司 Tartary buckwheat tea capable of losing weight, reducing lipid and relaxing bowels, and preparation method of tea
CN105124078A (en) * 2015-10-12 2015-12-09 青岛恒波仪器有限公司 Gardenia blood-glucose-reducing and lipid-reducing healthcare tea and preparing method thereof
CN106473099A (en) * 2016-10-12 2017-03-08 钟术光 Functional food or alternative tea that effect improves

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU189162B (en) * 1982-08-03 1986-06-30 Balogh,Gyula,Hu Process for the production of tea against fatness

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010002269A1 (en) * 1997-05-06 2001-05-31 Zhao Iris Ginron Multi-phase food & beverage
CN1270830A (en) * 1999-04-19 2000-10-25 郭立文 Sanjiangcha tea for reducing blood sugar, blood pressure and blood lipoid and its preparation
CN102047990A (en) * 2010-09-29 2011-05-11 吴肖慧 Traditional Chinese medicine health care tea for preventing and treating hyperlipidaemia
CN103734424A (en) * 2013-12-30 2014-04-23 青岛恒波仪器有限公司 Tartary buckwheat tea capable of losing weight, reducing lipid and relaxing bowels, and preparation method of tea
CN105124078A (en) * 2015-10-12 2015-12-09 青岛恒波仪器有限公司 Gardenia blood-glucose-reducing and lipid-reducing healthcare tea and preparing method thereof
CN106473099A (en) * 2016-10-12 2017-03-08 钟术光 Functional food or alternative tea that effect improves

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
李慧敏 等: "山茱萸降血糖作用研究进展", 《中药材》 *
李观林: "山茱萸中环烯醚萜苷类的研究进展", 《亚太传统医药》 *
苏鹏超 等: "UPLC法测定不同产地山茱萸中6种成分含量", 《陕西理工大学学报（自然科学版）》 *
赵艳艳 等: "山茱萸环烯醚萜总苷降血糖研究进展", 《陕西农业科学》 *
钟丽霞 等: "山楂多糖提取工艺优化及其降血糖、降血脂活性", 《食品工业科技》 *

Also Published As

Publication number Publication date
CN113397016B (en) 2022-08-02

Similar Documents

Publication Publication Date Title
KR100956278B1 (en) Composition comprising an extract of herbal combination thereof for preventing and treating diabetes mellitus
CN109527540A (en) A kind of preparation method of sea-buckthorn antihypelipidemic foodstuff
CN1299742C (en) Medicine for treating diabetes, and its prepn. method
KR20160007728A (en) Method for manufacturing garlic skin extract and food composition for preventing and alleviating diabetes prepared using the same
CN110624042B (en) Composition for treating diabetic diseases
KR20080018676A (en) Anti-diabetic food composition comprising extracts from natural herbal materials and propolis and process for preparing the same
WO1999025197A1 (en) Fenugreek compositions having reduced taste and odor and methods of use
CN102448479B (en) A novel antidiabetic furostanolic saponin rich (fsr) fraction from fenugreek seeds
CN105795292A (en) Drink containing corn stigma and ginseng and preparation method of drink
KR20120021864A (en) Antidiabetic composition comprising plants extract mixture
CN102813112B (en) Foodstuff for diabetic nephropathy
CN113397016B (en) Preparation method of dogwood and hawthorn table tea for reducing blood sugar
CN111450136A (en) Oyster and kudzu root composite particles and preparation method thereof
CN107136512A (en) A kind of vinegar capsule of auxiliary hyperglycemic reducing blood lipid and preparation method thereof
CN100484539C (en) Functional food with blood sugar reducing action and its preparing method
JP2003171303A (en) Composition comprising specific plant, and medicine and food for health use comprising the same composition as active ingredient
CN107260946A (en) A kind of health-care edible capsule preparation method with auxiliary hyperglycemic function
Viado et al. Anti-diabetic effects of Hibiscus spp. extract in rat and mice models: a review
JP2007520548A (en) Composition for prevention and treatment of diabetic complications
KR20100111088A (en) Composition for preventing and treating diabetes mellitus or diabetic complications comprising extract of herbal combination
CN106942439B (en) Cyclocarya paliurus and guava leaf blood glucose reducing tea and preparation method and application thereof
CN108077171A (en) A kind of cultural method of reed catkins chicken
CN107821538A (en) A kind of hypoglycemic biscuit and preparation method thereof
CN114916597B (en) Tea therapy composition for treating type 2 diabetes
CN108543002B (en) Mulberry grass hypoglycemic tablets and preparation process thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant