CN113368151A - Quick-acting antipyretic lotion and preparation method thereof - Google Patents

Quick-acting antipyretic lotion and preparation method thereof Download PDF

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CN113368151A
CN113368151A CN202110734675.9A CN202110734675A CN113368151A CN 113368151 A CN113368151 A CN 113368151A CN 202110734675 A CN202110734675 A CN 202110734675A CN 113368151 A CN113368151 A CN 113368151A
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quick
lotion
raw materials
antipyretic
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刘新平
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a quick-acting antipyretic lotion and a preparation method thereof. The quick-acting antipyretic dew comprises the following raw materials: sophora flavescens, sow thistle, bitter wood, dandelion, honeysuckle and honey-fried licorice root. The invention adopts an external application smearing type, has quick fever reduction, convenient use and definite curative effect; is especially suitable for infants, the elderly and patients with asthenia, and has no toxic side effects and drug allergy.

Description

Quick-acting antipyretic lotion and preparation method thereof
Technical Field
The invention relates to the technical field of medicines, in particular to quick-acting antipyretic dew and a preparation method thereof.
Background
Fever refers to pathological rise in body temperature, and is a systemic reaction of the human body to pathogenic factors. Generally speaking, the normal body temperature of an infant is usually measured as anal temperature of 36.5-37.5 ℃ and axillary temperature of 36-37 ℃, usually, the axillary temperature is 0.2-0.5 ℃ lower than the oral temperature (sublingual), the anal temperature is about 0.5 ℃ higher than the axillary temperature, and if the axillary temperature exceeds 37.4 ℃ and the daily fluctuation of the intermediate temperature exceeds 1 ℃, fever can be considered. The causes of fever can be divided into two main categories, infectious and non-infectious, with infection being the most common and the largest, including fever caused by systemic and focal infections caused by various acute, chronic, bacterial, viral and other pathogenic microorganisms. Because of weak disease resistance of infants, the infants are very easy to suffer from upper respiratory tract infection and cold, and simultaneously have high fever, and the body can be disordered in various regulation functions even if the body temperature is too high or the body temperature is too long, and the brain development is affected.
The existing antipyretic drugs on the market are mainly classified into three types, namely injection, oral agent and antipyretic patch, and have the following defects:
1. injection preparation: the traditional Chinese medicine composition is inconvenient to use, has slow fever reducing effect, basically takes effect in more than 30 minutes, has certain side effect and incomplete fever reducing, and is generally suitable for patients over 16 years old;
2. oral preparation: the children are inconvenient to feed and take, the fever reducing effect is slow, the effect is basically achieved within more than 40 minutes, certain side effects are caused, and the fever reducing is incomplete;
3. physical fever reducing plaster: has poor antipyretic effect.
Therefore, the problem to be solved by the technical personnel in the field is how to provide an antipyretic with convenient administration and good antipyretic effect.
Disclosure of Invention
In view of the above, the invention provides a quick-acting antipyretic lotion and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a quick-acting antipyretic lotion comprises the following raw materials: sophora flavescens, sow thistle, bitter wood, dandelion, honeysuckle and honey-fried licorice root.
Preferably, the raw materials are proportioned according to the following parts by weight: 4-5 parts of radix sophorae flavescentis, 2-3 parts of sow thistle, 4-5 parts of quassia, 2-3 parts of dandelion, 2-3 parts of honeysuckle and 1-2 parts of honey-fried licorice root.
Adopt above-mentioned technical scheme's beneficial effect: the lightyellow sophora root is bitter in taste and cold in nature, enters heart, liver, stomach, large intestine and bladder channels, clears heat and dries dampness, and promotes urination; the quassia is bitter in taste and cold in nature, enters lung channels and large intestine channels, clears away heat and toxic materials, eliminates dampness and kills insects; antibacterial, anti-inflammatory, dampness eliminating and toxic materials removing effects; the two medicines are the monarch medicines. The bitter herbs are bitter in taste and cold in nature, enter heart, spleen, stomach and large intestine channels, and cool blood and stop bleeding as ministers. Dandelion is sweet in taste, mild in nature and slightly cold, and enters liver and stomach meridians; promoting urination and resolving hard mass; the honeysuckle flower is sweet in taste and cold in nature, enters heart, liver, spleen, lung and kidney, clears away heat and toxic materials, and diminishes inflammation and subsides swelling; respectively as an adjuvant. Mix the herbs with prepared licorice. The whole prescription is bitter in taste and cold in nature, enters heart, liver, spleen, lung, kidney, stomach, large intestine, bladder and other eight meridians, and has the effects of clearing away heat and toxic materials, resisting bacteria, diminishing inflammation, eliminating dampness, killing parasite, cooling blood, stopping bleeding, promoting urination, and resolving hard mass. Therefore, the traditional Chinese medicine composition has obvious curative effects on upper respiratory tract infection, sore throat, tonsillitis, pneumonia, acute and chronic gastroenteritis, dysentery and the like.
Preferably, the raw materials are proportioned according to the following parts by weight: 4 parts of radix sophorae flavescentis, 2 parts of sow thistle, 4 parts of quassia, 2 parts of dandelion, 2 parts of honeysuckle and 1 part of honey-fried licorice root.
The invention also discloses a preparation method of the quick-acting antipyretic dew, which comprises the following steps:
(1) weighing radix Sophorae Flavescentis, herba Sonchi Oleracei, ramulus Et folium Picrasmae, herba Taraxaci, flos Lonicerae, and radix Glycyrrhizae Preparata at a certain ratio;
(2) decocting the above materials with strong fire for 150 min, filtering to remove residue, decocting for 30-60 min, concentrating, naturally cooling, filtering, precipitating, adding antistaling agent, and packaging.
Preferably, in the step (2), the raw materials are added with clear water 15-30 times of the weight of the raw materials, and the mixture is decocted by heating and concentrated to 60-80% of the raw materials.
Preferably, 0.3-0.5% of sodium deoxyacetate is added as a preservative after the precipitate is filtered in the step (2).
Adopt above-mentioned technical scheme's beneficial effect: for fever and headache caused by cold, the product can be applied on the eyebrow and the heart by 0.5-1 g to reduce fever and relieve pain; the Chinese medicinal composition has obvious effects on diseases such as upper respiratory tract infection, sore throat, tonsillitis, pneumonia, acute and chronic gastroenteritis, dysentery and the like, and can be orally taken by 9-15 g every day under the guidance of a traditional Chinese medical doctor.
The invention has the beneficial effects that:
1. the quick-acting antipyretic dew prepared by the invention is bitter in taste and cold in nature, and enters the lung channel of hand Taiyin, the large intestine channel of hand yangming and the stomach channel of foot yangming; when in use, the medicine properties rapidly enter lung channels, large intestine channels and stomach channels through the governor vessel, and heat evil is removed, so that the body function is restored to the yin-yang balance state, thereby achieving the purpose of treatment;
2. the quick-acting antipyretic lotion prepared by the invention is mainly used for treating fever and infection caused by respiratory tract infection, pneumonia, acute tonsillitis, acute gastroenteritis and the like, has excellent antipyretic effect for children, takes effect after being used for 1 minute, has antipyretic effect after being used for 3-10 minutes, and can be used for 1-3 times; the product can be taken 3 min after adult administration, and has effect of relieving fever in 10-20 min for 2-4 times; more importantly, the product can be used for infants, the old and the weak;
3. the external application smearing type fever reducing agent is adopted, has the advantages of quick fever reducing, convenient use and definite curative effect; is especially suitable for infants, does not enter human bodies, and has no toxic or side effect and drug anaphylactic reaction;
4. the product can also be made into a medicament fever reducing plaster in use, and can also be used for treating swelling and pain caused by trauma; skin itch, eczema, and the like; it can also be used with cautions for pregnant women to treat dysentery and pneumonia under the guidance of professional Chinese medical doctors.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The preparation method of the quick-acting antipyretic lotion comprises the following steps:
(1) according to the mass ratio of 4: 2: 4: 2: 2: 1 weighing radix sophorae flavescentis, bitter herbs, bitter wood, dandelion, honeysuckle and honey-fried licorice roots;
(2) mixing the raw materials according to the proportion of 1: 20 adding clear water, decocting with strong fire, decocting with medium fire for 135 min after boiling with water, filtering out the residue, decocting for 30 min, concentrating to two thirds of the original amount, naturally cooling, filtering, precipitating, adding 0.3% deoxysodium acetate as antistaling agent, packaging in a bottle, and packaging.
Example 2
(1) According to the weight ratio of 5: 2: 4: 2: 3: 2 weighing radix Sophorae Flavescentis, herba Sonchi Oleracei, ramulus Et folium Picrasmae, herba Taraxaci, flos Lonicerae, and radix Glycyrrhizae Preparata;
(2) mixing the raw materials according to the proportion of 1: adding clear water to decoct the decoction with the excessive fire, boiling the decoction with water, decocting the decoction with medium fire for 150 minutes, filtering out the residue, decocting the decoction for 30 minutes, concentrating the decoction to two thirds of the original amount, naturally cooling the decoction, filtering out the precipitate, adding 0.5 percent of sodium deoxyacetate serving as a preservative, and subpackaging the preservative in a bead bottle for later use.
Example 3
(1) According to the weight ratio of 4: 2: 5: 2: 3: 1 weighing radix sophorae flavescentis, bitter herbs, bitter wood, dandelion, honeysuckle and honey-fried licorice roots;
(2) mixing the raw materials according to the proportion of 1: 15 adding clear water, decocting with strong fire, decocting with medium fire for 135 min after boiling with water, filtering out the residue, decocting for 60 min, concentrating to two thirds of the original amount, naturally cooling, filtering, precipitating, adding 0.3% deoxysodium acetate as antistaling agent, packaging in a bottle, and packaging.
Case 1: some Deng, male, 5 years old, a sudden fever, listlessness, anorexia, dizziness, general pain after getting up in the morning; the body temperature is measured by a gun type thermometer to be 38.7 ℃, the quick-acting fever-reducing lotion is smeared on the Yintang acupoint for four circles, after 3 minutes, the spirit is recovered, the appetite is recovered, and the body temperature is measured again to be 36.6 ℃. The body temperature rises at noon, measured at 38.2 ℃, and the patient is in bed rest and is not taken. The body temperature is 38.6 ℃ at 30 minutes in the afternoon, the quick-acting antipyretic dew is taken again and smeared for two circles, then the temperature is measured continuously by using a gun type thermometer at intervals of about 30 seconds, the body temperature is continuously reduced, and the body temperature is recovered to 36.6 ℃ at 2 minutes and 50 seconds and is not reduced any more. The mental state returns to normal. After that, the observation is continued for two days, no adverse symptoms exist, and diet, sleep and defecation are all normal. Through the disease example, we find that: the product has antipyretic and certain curative effect on fever caused by external infection.
Case 2: a certain hair, male, 80 years old, has a superficial and rapid pulse, general pain, weak sweating, high fever of 39.5 ℃, and is diagnosed as wind-cold type of exogenous disease; the product is smeared on the Yintang acupoint for four circles, the body temperature is reduced to 37.5 ℃ within 8 minutes, the cassia twig decoction is decocted for one time, and the appetite is recovered after the bed rests for 4 and half hours, and the pain is completely absent. For the elderly patients, because of their complicated physical conditions, when using antipyretic drugs, they should be supplemented with drugs for regulating the balance of yin and yang in order to recover their health as soon as possible.
Case 3: when a certain old woman is aged for 42 years, the pain of bruise and bruise is caused after ankle sprain, the pain is relieved after 2 minutes by applying the product to an affected part, the pain disappears after ten minutes, and the pain is not relieved after follow-up visit on the next day. The case shows that the product has obvious effects of relieving swelling and pain.
Case 4: performing intestinal anastomosis operation on somebody in Tang Dynasty, male, 10 months, premature infant, and one month before, crying and screaming continuously, measuring body temperature to 39.8 deg.C, spitting out immediately after taking ibuprofen, burning for 30 min, and deep and thready pulse; immediately smearing the product on the Yintang acupoint of the eyebrow of the infant for two circles when a doctor is unconscious, stopping crying and screaming of the infant after one minute, and taking out a mercury thermometer from the armpit after 5 minutes, wherein the reading is 39.2 ℃; the body temperature was monitored continuously and ten minutes later the thermometer was taken out and read at 38.2 ℃. The infant is a fever caused by the inflammation of the operation wound, which is not caused by exogenous infection, so other treatment measures are needed, and the low fever state is maintained to fully play the role of the autoimmune system, so the infant is not cooled continuously.
Case 5: in Tanzhi, male and 11 years old, foot ulcer caused by beriberi causes fever to 39 ℃, the product is firstly smeared on the Yintang acupoint for four circles, the body temperature is reduced to 37.7 ℃ after 3 minutes, then the patient goes to a hospital to check fungal infection, and the beriberi is treated by ointment and other medicines; the body temperature floats between 37.5 and 38 ℃ after home return, the body temperature returns to normal in the next morning without continuously using antipyretics. We found that when the antipyretic is used, the antipyretic does not interfere with the normal action of the immune system of human body, and is more beneficial to controlling risks and treating diseases.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (5)

1. The quick-acting antipyretic lotion is characterized by comprising the following raw materials: sophora flavescens, sow thistle, bitter wood, dandelion, honeysuckle and honey-fried licorice root.
The quick-acting antipyretic lotion as claimed in claim 1, wherein the raw materials are proportioned according to the following parts by weight: 4-5 parts of radix sophorae flavescentis, 2-3 parts of sow thistle, 4-5 parts of quassia, 2-3 parts of dandelion, 2-3 parts of honeysuckle and 1-2 parts of honey-fried licorice root.
2. The quick-acting antipyretic lotion as claimed in claim 2, wherein the raw materials are proportioned according to the following parts by weight: 4 parts of radix sophorae flavescentis, 2 parts of sow thistle, 4 parts of quassia, 2 parts of dandelion, 2 parts of honeysuckle and 1 part of honey-fried licorice root.
3. The preparation method of the quick-acting antipyretic lotion as claimed in claim 1 or 2, characterized by comprising the following steps:
(1) weighing radix Sophorae Flavescentis, herba Sonchi Oleracei, ramulus Et folium Picrasmae, herba Taraxaci, flos Lonicerae, and radix Glycyrrhizae Preparata at a certain ratio;
(2) decocting the above materials with strong fire for 150 min, filtering to remove residue, decocting for 30-60 min, concentrating, naturally cooling, filtering, precipitating, adding antistaling agent, and packaging.
4. The method for preparing the quick-acting antipyretic lotion as claimed in claim 3, wherein in step (2), the raw materials are added with clear water 15-30 times of the weight of the raw materials, decocted by heating, concentrated to 60-80% of the raw materials, and then naturally cooled.
5. The method for preparing the quick-acting antipyretic dew as claimed in claim 3, wherein 0.3-0.5% of sodium deoxyacetate is added as an antistaling agent after the precipitate is filtered in step (2).
CN202110734675.9A 2021-06-30 2021-06-30 Quick-acting antipyretic lotion and preparation method thereof Pending CN113368151A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103461607A (en) * 2013-09-26 2013-12-25 王文泉 Honeysuckle compound tea

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103461607A (en) * 2013-09-26 2013-12-25 王文泉 Honeysuckle compound tea

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Application publication date: 20210910