CN113348164A - 一种稠合三环衍生物的制备方法及中间体 - Google Patents

一种稠合三环衍生物的制备方法及中间体 Download PDF

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Publication number
CN113348164A
CN113348164A CN201980064627.4A CN201980064627A CN113348164A CN 113348164 A CN113348164 A CN 113348164A CN 201980064627 A CN201980064627 A CN 201980064627A CN 113348164 A CN113348164 A CN 113348164A
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formula
compound
reaction
tert
reacting
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CN113348164B (zh
Inventor
李瑶
王文晶
张国彪
石宗军
陈雷
张晨
严庞科
郑伟
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Sichuan Haisco Pharmaceutical Co Ltd
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Sichuan Haisco Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明提供了一种稠合三环衍生物的制备方法及中间体。所述稠合三环衍生物具有式(I)所示的结构。所述制备方法原料易得、步骤简单，适宜大规模工业化生产。

Description

PCT国内申请，说明书已公开。

Claims (28)

  1. PCT国内申请，权利要求书已公开。
CN201980064627.4A 2019-02-01 2019-12-25 一种稠合三环衍生物的制备方法及中间体 Active CN113348164B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910077078 2019-02-01
CN2019100770786 2019-02-01
PCT/CN2019/128253 WO2020155952A1 (zh) 2019-02-01 2019-12-25 一种稠合三环衍生物的制备方法及中间体

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CN113348164A true CN113348164A (zh) 2021-09-03
CN113348164B CN113348164B (zh) 2023-08-29

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TW (1) TWI755667B (zh)
WO (1) WO2020155952A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113333173B (zh) * 2021-05-13 2022-06-21 西北矿冶研究院 一种锡矿浮选锡的选矿药剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106946917A (zh) * 2017-03-20 2017-07-14 杭州科巢生物科技有限公司 一种jak抑制剂巴瑞替尼及其中间体的新合成方法
CN109021065A (zh) * 2017-06-08 2018-12-18 复旦大学 一种制备高抗癌活性肽海兔毒素Dolastatin10的方法
EP3497090A1 (en) * 2016-08-09 2019-06-19 Laurus Labs Limited Novel processes for preparation of dapagliflozin or its solvates or co-crystals thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017114225A1 (zh) * 2015-12-31 2017-07-06 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用
JP7001679B2 (ja) * 2016-09-14 2022-02-04 四川海思科制▲薬▼有限公司 縮合３環γ－アミノ酸誘導体及びその製造方法、並びに医薬における応用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3497090A1 (en) * 2016-08-09 2019-06-19 Laurus Labs Limited Novel processes for preparation of dapagliflozin or its solvates or co-crystals thereof
CN106946917A (zh) * 2017-03-20 2017-07-14 杭州科巢生物科技有限公司 一种jak抑制剂巴瑞替尼及其中间体的新合成方法
CN109021065A (zh) * 2017-06-08 2018-12-18 复旦大学 一种制备高抗癌活性肽海兔毒素Dolastatin10的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TAKESHI OKADA等: "Isomerization Polymerization of 4-Alkylcyclopentenes Catalyzed by Pd Complexes: Hydrocarbon Polymers with Isotactic-Type Stereochemistry and Liquid-Crystalline Properties" *

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WO2020155952A1 (zh) 2020-08-06
TW202043186A (zh) 2020-12-01
TWI755667B (zh) 2022-02-21
CN113348164B (zh) 2023-08-29

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