CN113318173A

CN113318173A - Traditional Chinese medicine composition and application thereof in medicine for treating intractable skin trauma

Info

Publication number: CN113318173A
Application number: CN202110686741.XA
Authority: CN
Inventors: 康龙群
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-06-21
Filing date: 2021-06-21
Publication date: 2021-08-31

Abstract

The invention relates to a traditional Chinese medicine composition and application thereof in medicines for treating chronic skin trauma, wherein the traditional Chinese medicine composition comprises the following raw material components: 3-8 parts of cortex lycii radicis, 5-10 parts of dandelion, 2-5 parts of Chinese olive, 3-8 parts of radix rehmanniae recen, 5-10 parts of pseudo-ginseng, 5-15 parts of coptis chinensis, 3-8 parts of henbane, 5-10 parts of rheum officinale, 5-10 parts of raw Chinese yam, 5-15 parts of philippine violet herb, 5-10 parts of honeysuckle, 2-5 parts of sculellaria barbata and 1-5 parts of sesame flower. The traditional Chinese medicine composition has an obvious treatment effect on the aspect of treating the wound difficult to heal of the diabetes, and can also treat burn, senile acne, osteomyelitis, wound disunion after an operation, common skin trauma of a human body and the like. The invention has the advantages of quick effect, high cure rate, low cost, easily obtained raw materials, simple preparation method, convenient use and suitability for popularization and application.

Description

Traditional Chinese medicine composition and application thereof in medicine for treating intractable skin trauma

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and application thereof in medicines for treating chronic skin trauma.

Background

After injury, the time for wound healing is related to the size of the wound, with small wounds taking three to five days to completely return to normal, and large wounds taking ten days and a half month. However, some patients cannot heal the wound for several months, for example, diabetic vasculopathy and neuropathy can be caused when blood sugar control of the diabetic patients is poor, and wound healing can be influenced due to poor nutrition of the diabetic vasculopathy and neuropathy. Meanwhile, the diabetic is easy to cause the long-term unhealed wounds in the conditions of poor nutritional state and hypoproteinemia. At present, the treatment of wounds for diabetics is a difficult problem in wound treatment. In addition, if there is infection in the wound, such as infectious surgery, suppurative surgery, etc., the wound is difficult to heal.

At present, no medicine specially aiming at the special wounds exists, and the development of the medicine has better clinical application prospect.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition which has better effects of clearing heat and removing toxicity, cooling blood and eliminating swelling, astringing dampness and astringing wounds, drawing out pus and removing necrotic tissue, and stewing pus and promoting granulation, and has obvious treatment effect on non-healing skin trauma caused by various reasons, especially wounds which cannot be healed by diabetics.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides a traditional Chinese medicine composition which comprises the following raw material components in parts by weight: 3-8 parts of cortex lycii radicis, 5-10 parts of dandelion, 2-5 parts of Chinese olive, 3-8 parts of radix rehmanniae recen, 5-10 parts of pseudo-ginseng, 5-15 parts of coptis chinensis, 3-8 parts of henbane, 5-10 parts of rheum officinale, 5-10 parts of raw Chinese yam, 5-15 parts of philippine violet herb, 5-10 parts of honeysuckle, 2-5 parts of sculellaria barbata and 1-5 parts of sesame flower. Preferably, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 5 parts of cortex lycii radicis, 8 parts of dandelion, 3 parts of Chinese olive, 5 parts of radix rehmanniae recen, 8 parts of pseudo-ginseng, 10 parts of coptis chinensis, 5 parts of henbane, 8 parts of rheum officinale, 6 parts of raw Chinese yam, 10 parts of Chinese violet, 6 parts of honeysuckle, 3 parts of barbed skullcap herb and 2 parts of sesame flower.

The traditional Chinese medicine composition disclosed by the invention has the following raw material effects and formula mechanisms:

cortex Lycii, sweet and bland in flavor and cold in nature. It enters lung, liver and kidney meridians. Clear heat, relieve steaming, cool blood. Can be used for treating fever due to yin deficiency, cough due to lung heat, hemorrhage due to blood heat, and diabetes.

Dandelion, bitter and sweet in taste and cold in nature. It enters liver and stomach meridians. Clearing away heat and toxic material, dispersing swelling and dissipating stagnation, inducing diuresis and treating stranguria. Can be used for treating furuncle, swelling, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with astringency and pain due to heat.

Qing Guo is sweet and sour in flavor and neutral in nature. It enters lung and stomach meridians. Clear heat and remove toxicity, relieve sore throat and promote the production of body fluid. Can be used for treating swelling and pain of throat, cough, sticky phlegm, dysphoria with smothery sensation, thirst, and fish and crab poisoning.

Sheng Di Huang is sweet and bitter in flavor and cold in nature. It enters heart, liver and kidney meridians. Clear heat and cool blood, nourish yin and promote the production of body fluid. It can be used for treating febrile disease, vexation, crimson tongue, hematemesis, epistaxis, macula, purple black, yin impairment due to febrile disease, diabetes, and polydipsia.

Notoginseng, sweet in taste, slightly bitter in flavor and warm in nature. It enters heart, liver and spleen meridians. Resolve blood stasis, stop bleeding, relieve swelling and alleviate pain. Can be used for treating internal and external hemorrhage, traumatic injury, and swelling and pain due to blood stasis.

Huang Lian is bitter in taste and cold in nature. It enters heart, stomach, liver and large intestine meridians. Clear heat and dry dampness, purge fire and remove toxicity. Can be used for treating gastrointestinal damp-heat, emesis, dysentery, hyperpyrexia, coma, vexation, insomnia, hematemesis, epistaxis, pyocutaneous disease, toxic swelling, suppurative otitis, eczema, stomach fire, and toothache.

Tian Xian Zi is bitter and pungent in flavor and warm in nature. It is toxic. It enters heart, liver and stomach meridians. Relieve spasm and pain, relieve cough and dyspnea, calm the nerves and relieve convulsion, astringe and relieve depletion. It can be used for treating abdominal pain, rheumatalgia, toothache, traumatic injury, cough, asthma, pertussis, mania, epilepsy, dysentery, rectocele, carbuncle, skin ulcer, and furuncle.

Da Huang is bitter in taste and cold in nature. It enters spleen, stomach, large intestine, liver and pericardium meridians. Purging pathogenic accumulation, clearing heat and purging fire, cooling blood and removing toxicity, activating blood and dispelling stasis. Can be used for treating intestinal stagnation, constipation, hematemesis, conjunctival congestion, pharyngalgia, gingival swelling and pain, pyocutaneous disease, scald, blood stasis, amenorrhea, traumatic injury, jaundice due to damp-heat pathogen, and heat stranguria.

Raw yam is sweet in flavor and neutral in nature. Tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and asthenic fever.

Viola Yedoensis Makino is bitter and pungent in flavor and cold in nature. It enters heart and liver meridians. Clear heat and remove toxicity, cool blood and relieve swelling. Can be used for treating furuncle, pyogenic infection, carbuncle, cellulitis, carbuncle, erysipelas, and snake bite.

Honeysuckle flower, sweet in taste and cold in nature. It enters lung and stomach meridians. Clearing away heat and toxic material, diminishing inflammation and relieving swelling. It can be used for treating fever due to affection of exogenous wind-heat or epidemic febrile disease, heatstroke, toxic heat, dysentery, carbuncle, furuncle, pharyngitis, and various infectious diseases.

Scutellaria barbata is pungent, bitter and cold in nature. It enters lung, liver and kidney meridians. Clearing away heat and toxic material, dispersing blood stasis and promoting urination. Can be used for treating furuncle, swelling and pain of throat, traumatic injury, edema, jaundice, and snake and insect bite.

Sesame flower, sweet and pungent in flavor and mild in nature. It enters lung and liver meridians. Promote blood circulation to regulate menstruation, cool blood and clear heat with herbs. It is commonly used for irregular menstruation, dysmenorrhea, leucorrhea with reddish discharge, fever and hemoptysis due to lung-heat, and pain due to stranguria with urine.

According to the traditional Chinese medicine composition, the coptis chinensis clears heat and dries dampness, and purges fire and detoxifies; da Huang cools blood and detoxifies toxicity, activates blood and removes stasis, and they are the monarch drugs together. The herba violae, the honeysuckle, the sculellaria barbata, the cortex lycii radicis, the dandelion, the Chinese olive and the radix rehmanniae enhance the effects of the monarch drug on clearing away heat and toxic materials, cooling blood and relieving swelling, and are used as ministerial drugs together. Pseudo-ginseng has the effects of promoting blood circulation, henbane astringing, raw Chinese yam promoting granulation and sesame flower anti-inflammation, and the 4 medicines assist in multiple aspects. The whole formula has 13 medicines which are compatible, and has the effects of clearing heat and removing toxicity, cooling blood and detumescence, astringing dampness and astringing wound, drawing out pus and removing necrotic tissue, stewing pus and promoting granulation.

The traditional Chinese medicine composition can be prepared into any external pharmaceutical dosage form by adding conventional auxiliary materials according to a general pharmaceutical method. Preferably, the Chinese medicinal composition is in the form of external powder.

The invention also provides a preparation method of the external powder of the traditional Chinese medicine composition, which comprises the following steps: respectively taking cortex lycii radicis, dandelion, Chinese olive, radix rehmanniae, pseudo-ginseng, coptis chinensis, henbane, rheum officinale, raw Chinese yam, Chinese violet, honeysuckle, barbed skullcap herb and sesame flower, respectively drying, crushing and sieving to obtain fine powder of each raw material, preferably, crushing and sieving by a 60-80-mesh sieve; and uniformly mixing the fine powder of the raw materials to obtain the external powder of the traditional Chinese medicine composition.

The invention has remarkable treatment effect on the long-term skin trauma caused by various reasons, including but not limited to the non-healing of diabetes wounds, burn, senile acne, osteomyelitis, non-healing of postoperative wounds and the like. The clinical use effect proves that: 1. diabetic complications ulceration: the medicine can be cured in 3-6 months under the condition of good blood sugar control, and the cure rate is 80 percent; 2. acne of the old: the healing period of bedsore caused by long-term bed rest is 1-2 months; 3. osteomyelitis; the cure rate is more than 80 percent, and the treatment period is 2-4 months; 4. non-healing of the wound after surgery: the wound is healed in 7-12 days; 5. and (3) burning: the burn ointment comprises electric burn, gas burn, oil burn, boiled water burn, fire burn, alcohol burn, asphalt burn, explosive burn, oxygen burn during construction and the like, and has obvious application effect according to specific burn degree; 6. the external injury of human body and the common skin trauma can be cured. Therefore, the invention also relates to the application of the traditional Chinese medicine composition in preparing a medicine for treating the skin trauma which is not healed for a long time. Preferably, the medicament is used for treating diabetic wounds, burns, senile acne, osteomyelitis and postoperative wounds.

The invention has the beneficial effects that:

1. the traditional Chinese medicine composition has good effects of clearing heat and removing toxicity, cooling blood and eliminating swelling, astringing dampness and astringing wounds, drawing out pus and removing putrefaction, stewing pus and promoting granulation, can remarkably improve local blood circulation of wounds, stimulates skin regeneration, and further plays an excellent role in repairing skin wound surfaces. Clinical application shows that the traditional Chinese medicine composition has a good treatment effect on long-lasting skin trauma caused by various reasons, particularly on the aspect of treating diabetic foot necrosis which is one of chronic complications of diabetes, the traditional Chinese medicine composition obviously shortens the healing time of a skin wound and improves the wound healing rate, thereby greatly reducing the disability rate of the disease and providing a new medicine solution for clinical treatment of the disease. In addition, the invention can treat burns (including electric burns, gas burns, oil burns, boiled water burns, fire and light burns, alcohol burns, asphalt burns, explosive burns, oxygen burns during construction, etc.), senile acne, osteomyelitis, non-healing wounds after operation, and common skin traumas of human body, such as cuts, grazes, lacerations, punctures, cuts, bites, crush injuries, etc. The invention has quick effect, high cure rate and no scar left after healing for treating various skin wound surfaces.

2. The traditional Chinese medicine composition is easy to prepare into various convenient medicinal dosage forms, for example, when the traditional Chinese medicine composition is prepared into external powder, the traditional Chinese medicine composition is directly spread on the wound surface by taking the size of the wound surface as a limit, and has the characteristic of convenient use.

3. The traditional Chinese medicine composition provided by the invention has the advantages of readily available raw materials, simple preparation method, low treatment cost and suitability for popularization and application.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.

Example 1

The embodiment provides a traditional Chinese medicine powder for external use, which is prepared from the following raw materials in parts by weight:

5 parts of cortex lycii radicis, 8 parts of dandelion, 3 parts of Chinese olive, 5 parts of radix rehmanniae recen, 8 parts of pseudo-ginseng, 10 parts of coptis chinensis, 5 parts of henbane, 8 parts of rheum officinale, 6 parts of raw Chinese yam, 10 parts of Chinese violet, 6 parts of honeysuckle, 3 parts of barbed skullcap herb and 2 parts of sesame flower.

The preparation method of the traditional Chinese medicine powder for external use described in this embodiment includes the following steps:

respectively drying and crushing cortex lycii radicis, dandelion, Chinese olive, radix rehmanniae, pseudo-ginseng, coptis chinensis, henbane, rheum officinale, raw Chinese yam, Chinese violet, honeysuckle, barbed skullcap herb and sesame flower, sieving by a 60-mesh sieve to obtain fine powder of each raw material, and uniformly mixing the fine powder of each raw material to obtain the Chinese medicinal preparation.

Example 2

3 parts of cortex lycii radicis, 10 parts of dandelion, 2 parts of Chinese olive, 8 parts of radix rehmanniae recen, 5 parts of pseudo-ginseng, 15 parts of coptis chinensis, 3 parts of henbane, 10 parts of rheum officinale, 5 parts of raw Chinese yam, 15 parts of Chinese violet, 5 parts of honeysuckle, 5 parts of barbed skullcap herb and 1 part of sesame flower.

respectively drying and crushing cortex lycii radicis, dandelion, Chinese olive, radix rehmanniae, pseudo-ginseng, coptis chinensis, henbane, rheum officinale, raw Chinese yam, Chinese violet, honeysuckle, barbed skullcap herb and sesame flower, sieving by a 80-mesh sieve to obtain fine powder of each raw material, and uniformly mixing the fine powder of each raw material to obtain the Chinese medicinal preparation.

Example 3

8 parts of cortex lycii radicis, 5 parts of dandelion, 5 parts of Chinese olive, 3 parts of radix rehmanniae recen, 10 parts of pseudo-ginseng, 5 parts of coptis chinensis, 8 parts of henbane, 5 parts of rheum officinale, 10 parts of raw Chinese yam, 5 parts of Chinese violet, 10 parts of honeysuckle, 2 parts of barbed skullcap herb and 5 parts of sesame flower.

Typical treatment effect case of the invention

The first treatment case is as follows: for Liu ladies and diabetics, foot and face ulceration is serious, hospitalization is carried out in Yichuan county people hospitals in 11 months in 2020, doctors and family members talk for many times, the wounds cannot heal, amputation is recommended, but the years are considered to be high, the patients cannot suffer from the pain, after the hospital stays in the spring festival, children require to be discharged, the medicine treatment (the medicine in the embodiment 1) is started after the discharge, the obvious improvement is started after the medicine is taken for half a month, the wounds with large-area ulceration gradually heal, the wounds are basically healed after the medicine is taken for four months, and the patients can walk freely at present.

The second treatment case: guo in Yichuan county electric administration, in 2017, due to the maintenance of the transformer, the patient is cured for more than half a year in the liberated military 150 hospital, and the patient cannot be cured in the last day due to the size of eggs in the chest, and after discharge, the patient is treated by the medicine (the medicine in example 2) provided by the invention, and the patient can be cured in about one week.

Treatment case three: in Li Jie, 53 years old, and 2019, the national enterprise and construction sites are dry and alive, and the burn caused by oxygen leakage has no effect after being treated for many times in local hospitals, and the burn is cured after the local hospitals return to home and are treated once by using the medicament (the medicament in the example 2).

Treatment case four: kangzhi, 73 years old, when the asphalt pavement is paved on the highway bureau in Ischuan county in 2020 July, the burn on the sole can be cured after one treatment by adopting the medicine (the medicine in the embodiment 1) of the invention.

Treatment case five: li Shi, doctor of peace Hospital, Ischuan county, has no effect on treating bedsore caused by bedridden patients for a long time, and the effect is very obvious after the treatment by using the medicament (the medicament in the embodiment 1) of the invention is used for treating bedsore, and the bedsore is cured soon.

Six treatment cases: zhangzhi, 12 months in 2020, the operation is performed in the medical hospital of Yichuan county because of the back being packed long, the medicine is changed every two days after the operation, but the wound can not be healed all the time, and then no effect is produced after the third hospital in Luoyang city treats for half a year, and the medicine (the medicine in the embodiment 1) is introduced to treat the wound for 5 days later.

Seven treatment cases: zhangzhi, working in starch factories in local villages and towns in 1991, the device is broken by fingers in maintenance in one work, long-term treatment has no effect, direct-flow pus is remained, medical treatment is performed everywhere in the last decade, the patient is identified as osteomyelitis by hospitals, treatment with the medicine (the medicine in example 2) is introduced in 2018, and the patient is cured after three months.

Eight treatment cases: duji, 14 years old, 2012 fried his palm very badly in the local neighborhood because of the use of explosives, and healed after one treatment with the drug of the invention (example 3 drug).

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The traditional Chinese medicine composition is characterized by comprising the following raw material components in parts by weight:

3-8 parts of cortex lycii radicis, 5-10 parts of dandelion, 2-5 parts of Chinese olive, 3-8 parts of radix rehmanniae recen, 5-10 parts of pseudo-ginseng, 5-15 parts of coptis chinensis, 3-8 parts of henbane, 5-10 parts of rheum officinale, 5-10 parts of raw Chinese yam, 5-15 parts of philippine violet herb, 5-10 parts of honeysuckle, 2-5 parts of sculellaria barbata and 1-5 parts of sesame flower.

2. The traditional Chinese medicine composition according to claim 1, which comprises the following raw material components in parts by weight:

3. The Chinese medicinal composition according to claim 1 or 2, wherein the dosage form of the Chinese medicinal composition is any pharmaceutical dosage form suitable for external use.

4. The traditional Chinese medicine composition of claim 3, wherein the traditional Chinese medicine composition is in the form of external powder.

5. The method for preparing a powder for external use of the Chinese medicinal composition as claimed in claim 4, comprising the steps of: respectively drying, crushing and sieving cortex lycii radicis, dandelion, Chinese olive, radix rehmanniae, pseudo-ginseng, coptis chinensis, henbane, rheum officinale, raw Chinese yam, Chinese violet, honeysuckle, barbed skullcap herb and sesame flower to obtain raw material fine powder, and uniformly mixing the raw material fine powder to obtain the external powder of the traditional Chinese medicine composition.

6. The method for preparing a powder for external use of a Chinese medicinal composition according to claim 5, wherein the powder is pulverized and then sieved with a 60-80 mesh sieve.

7. Use of a Chinese medicinal composition according to claim 1 or 2 for the preparation of a medicament for the treatment of prolonged skin trauma.

8. The use of claim 7, wherein the medicament is a medicament for treating a diabetic wound.

9. The use of claim 7, wherein the medicament is a medicament for treating burns, acne senilis, osteomyelitis, or post-operative wounds.