CN113318033A

CN113318033A - Toothpaste capable of preventing excessive internal heat and preparation method thereof

Info

Publication number: CN113318033A
Application number: CN202110713432.7A
Authority: CN
Inventors: 张海
Original assignee: Guangzhou Happy Struggle Industrial Co ltd
Current assignee: Guangzhou Happy Struggle Industrial Co ltd
Priority date: 2021-06-25
Filing date: 2021-06-25
Publication date: 2021-08-31

Abstract

The invention discloses a fire-preventing toothpaste and a preparation method thereof, and relates to the technical field of toothpaste processing. The internal heat prevention toothpaste comprises the following components: sorbitol, PEG-400, sodium carboxymethylcellulose, xanthan gum, saccharin sodium, tetrasodium pyrophosphate, sodium benzoate, green salt, an almond extract, a sophora twig extract, thickening silicon dioxide, cleaning silicon dioxide, sodium dodecyl sulfate, essence, pigment and the balance of water; the preparation method comprises the following steps: adding sorbitol and PEG-400 into paste making machine, weighing water into a pre-mixing tank, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate, stirring, sequentially adding thickening type silicon dioxide, sodium carboxymethylcellulose, xanthan gum, sodium dodecyl sulfate and cleaning type silicon dioxide, stirring, transferring paste making machine, weighing Halitum, semen Armeniacae amarum extract, ramulus Sophorae extract, essence and pigment, stirring, and stopping scraper. The preparation method is simple, and the gingival bleeding condition can be effectively improved.

Description

Toothpaste capable of preventing excessive internal heat and preparation method thereof

Technical Field

The invention relates to the technical field of toothpaste processing, in particular to a fire-proof toothpaste and a preparation method thereof.

Background

The toothpaste is a daily necessity, a considerable part of toothpaste in the toothpaste is fluorine-containing toothpaste, but experts point that children under 6 years old are at a high risk of using the fluorine-containing toothpaste, and excessive fluorine can not only cause the thinness of teeth but also reduce the hardness of bones because the fluorine is a toxic substance. Fluorine has been recognized by the world health organization as a trace element with potential toxicity, and lead and mercury trace elements are on the market. More than 20 provinces in China belong to high fluorine regions, and the use of toothpaste containing fluorine in these regions is undoubtedly frosting on snow. Toothpastes are complex mixtures. It is usually prepared by mixing an abrasive (such as calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, silicon dioxide, aluminum hydroxide), a humectant (such as glycerin, sorbitol, xylitol, polyethylene glycol and water), a surfactant (such as sodium lauryl sulfate, sodium 2-acyloxy-bonded sulfonate), a thickener (such as carboxymethyl cellulose, antler pectin, hydroxyethyl cellulose, xanthan gum, guar gum, carrageenan, etc.), a sweetener (such as glycerin, sodium cyclohexylamine sulfonate, sodium saccharin, etc.), a preservative (such as potassium sorbate and sodium benzoate), an active additive (such as chlorophyll, fluoride), a pigment, an essence, etc. The special toothpaste is toothpaste with special properties. The fluorine-containing toothpaste contains active substances such as sodium fluoride, stannous fluoride, sodium monofluorophosphate and zinc fluoride, and is effective in preventing dental caries. The chlorophyll toothpaste is added with chlorophyll, and has special effects of preventing gingival bleeding and preventing halitosis. The toothpaste containing enzyme can decompose residual food, and has effects of cleaning oral cavity and preventing worm damage. The medicated toothpaste can be added into toothpaste for treating oral diseases. The toothpaste of radix scutellariae, the toothpaste of sarcandra glabra and the like sold in the market have obvious functions of slowing down and treating gingival bleeding, gingival swelling, halitosis, dentin hypersensitivity and the like. The toothpaste is composed of powder abrasive, humectant, surfactant, binder, perfume, sweetener and other special components. In order to prevent and treat oral diseases, some special components are added into toothpaste: in order to remove halitosis, bactericides such as bis-oxo-phenyl-di-guanidino-hexane and cypress alcohol are added into toothpaste, and copper chlorophyllin also has certain effect on preventing halitosis. ② fluorine compounds can be added for preventing and treating dental caries, which can not only inhibit the fermentation of residues in the oral cavity, but also strengthen the enamel on the surface of the teeth. For safety reasons, the fluorine content of toothpastes is specified below 1000 micrograms. While the incidence of dental caries is relatively low among people who drink natural water containing fluorine, when water containing high content of fluorine is drunk, the tooth surface becomes white and turbid (spot-shaped teeth), and the tooth texture becomes brittle, thus endangering the oral cavity and the health condition.

The medicated toothpaste takes toothpaste as carrier, and is added with certain active drugs, so that the toothpaste reaches the surface of teeth or the environment around the teeth during tooth brushing, and various problems in the oral cavity are reduced under the action of the drugs, thereby playing the role of preventing dental caries and periodontal disease. The digestive tract of the human body comprises oral cavity, pharynx, esophagus, stomach and small intestine. Clinically, the digestive tract is usually divided into an upper digestive tract (above the duodenum) and a lower digestive tract (below the duodenum), and the oral cavity is used as the first gateway of the digestive tract and is also an organ which is easy to cause problems, and whether the health of the oral cavity is directly related to the overall health of the body. At present, more and more medicinal toothpaste is favored by people, and the promotion of the medicament with the prevention effect or the treatment effect by using the toothpaste as a carrier is an ideal oral health care mode. However, medicated toothpaste also has its disadvantages, firstly, toothpaste cannot be kept in the mouth for too long time, i.e. rinsed out, making it difficult for the drug to exert its effect in a short time, and the dosage of the special drug must also avoid irritating soft tissues in the mouth and thus cannot be increased to a sufficient effective concentration, and the effect of toothpaste itself is often blocked by dirt in the mouth or limited by morphological features, thus making it difficult to reach the area of real disease. Secondly, the medicines in the toothpaste usually have other chemical changes due to long-term storage, the original efficacy is lost, the effective medicines are often not suitable to be put into the toothpaste due to peculiar smell, and the medicine resistance problem exists.

In modern society, people have fast pace of life and high working pressure, and the problems of toothache, oral ulcer and the like generally exist, so that the normal life of people is greatly influenced, and therefore, the toothpaste which can clear heat, reduce internal heat, reduce swelling and relieve pain in the daily use process is urgently needed to be used as a daily oral care product.

Disclosure of Invention

The invention aims to provide a fire-preventing toothpaste and a preparation method thereof, which can effectively improve the current situation of gingival bleeding.

In order to achieve the aim, the invention provides an excessive-fire-proof toothpaste and a preparation method thereof, wherein the excessive-fire-proof toothpaste is prepared from the following components in percentage by weight:

the toothpaste for preventing excessive internal heat is prepared from the following components in percentage by weight:

the fire-proof toothpaste is characterized in that the PEG-400 is purchased from Jinan crystal Hao chemical Co., Ltd, and the type number of the PEG-400 is TS 7;

the sodium carboxymethylcellulose is purchased from chemical company Limited of Jinma crystal Hao of Jinan of Ji, and has the model number TH 9;

the dosage ratio of the green salt to the almond extract to the sophora japonica branch extract is 2: 1: 1.

the Qingyan salt of the anti-excessive internal heat toothpaste is purchased from Qinghai Yingjude commercial and trade company Limited and has the model number of 418423;

the thickening silica is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the thickening silica is 10# -2 #;

the clean silicon dioxide is purchased from Guangzhou Highl New Material Co., Ltd, and the model number of the clean silicon dioxide is 10# -1 #.

The essence of the anti-inflammation toothpaste is purchased from Youdou Homophilus Biotech limited company, and the type number of the essence is DJ-4345;

the pigment is purchased from Zhengzhou Hengren chemotherapeutics products Co., Ltd, and the model number is SC 20141072100199.

The above-mentioned toothpaste for preventing excessive internal heat, the said almond extract is purchased from Fufeng Sinuote Biotechnology limited company, its model is TLC-1010;

the Japanese pagodatree twig extract is purchased from Tonghua Kangyuan biotechnology limited company, and the model number of the Japanese pagodatree twig extract is 01-4345.

The preparation method of the internal heat preventing toothpaste comprises the following steps:

(1) adding sorbitol and PEG-400 into a paste making machine according to the formula amount; simultaneously reserving sorbitol for washing the water-phase premixing pot;

(2) weighing water according to the formula amount, adding saccharin sodium, tetrasodium pyrophosphate and sodium benzoate according to the formula amount into a premixing tank, stirring for 15 minutes, stopping stirring, observing whether the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved, and continuously stirring until the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are dissolved if the saccharin sodium, the tetrasodium pyrophosphate and the sodium benzoate are not dissolved; wherein the vacuum degree is controlled to be-0.04 MPa to-0.08 MPa and then the mixture enters a paste making machine;

(3) adding thickening type silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and clean type silicon dioxide into a powder premixing and stirring pot according to the formula amount, and stirring for 5 minutes;

(4) controlling the vacuum degree to be-0.04 Mpa to-0.08 Mpa, sucking the powder obtained in the step (3) into a paste making machine, simultaneously opening double stirring blades and stirring for 15 minutes;

(5) weighing the green salt, the almond extract, the sophora japonica branch extract, the essence and the pigment according to the formula, then opening an aroma inlet valve, sucking the substances, closing the aroma inlet valve, starting a vacuum pump, stirring for 15 minutes, stopping stirring for two times, starting the vacuum pump, and continuing stirring for 10 minutes by a scraper, wherein the vacuum degree is not lower than-0.096 Mpa before ointment discharge;

(6) stopping the scraper, slowly opening an air release valve, recovering the normal pressure, and sampling and inspecting;

(7) and (5) obtaining paste after the detection is qualified.

The preparation method of the toothpaste for preventing excessive internal heat comprises the following step (2) of adding sodium monofluorophosphate according to the formula amount, wherein the amount of the sodium monofluorophosphate is 2 times of the amount of the sodium benzoate;

the step (3) also comprises the following components: zinc citrate, probiotic particles and titanium dioxide, wherein the dosage ratio of the zinc citrate to the probiotic particles to the titanium dioxide is 5: 1: 2; wherein the dosage of the probiotic particles is 1.5 times of the dosage of the sodium dodecyl sulfate; wherein the probiotic particles are purchased from Guangzhou Yuejiao industries, Inc.

According to the preparation method of the internal heat-preventing toothpaste, step (5) also comprises weighing sodium lauroyl sarcosine according to the formula amount, wherein the dosage of the sodium lauroyl sarcosine is 3 times of that of the essence.

The fire-preventing toothpaste and the preparation method thereof provided by the technical scheme have the following beneficial effects:

compared with the prior art, the application relates to the toothpaste for preventing excessive internal heat, the preparation method is simple, and the gingival bleeding condition can be effectively improved. Specifically, the raw materials fully utilize the green salt, the almond extract and the sophora twig extract, and the zinc citrate, the probiotic particles and the titanium dioxide are subjected to effective fusion reaction, so that the double-blind random test proves that the use has no adverse reaction and better and effective relief of gingival bleeding.

Detailed Description

The following examples are given to further illustrate the embodiments of the present invention. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.

Example 1

The fire-flaming preventing toothpaste and the preparation method thereof comprise the following components in percentage by weight:

(7) and (5) obtaining paste after the detection is qualified.

Example 2

(7) and (5) obtaining paste after the detection is qualified.

Example 3

(7) and (5) obtaining paste after the detection is qualified.

Example 4

(7) and (5) obtaining paste after the detection is qualified.

Example 5

(7) and (5) obtaining paste after the detection is qualified.

Test protocol

Taking the anti-excessive internal heat toothpaste prepared in example 5 as an example, the following clinical tests were performed:

(1) test unit: oral hospital in Guangdong province

(2) The purpose of the test is as follows: and verifying whether the toothpaste for preventing excessive internal heat has the efficacy of improving the gingival bleeding for the tested population.

(3) Test time: 1 month-2021 year-4 months 2021 year

(4) The test method comprises the following steps: the test method adopts a double-blind and random test design, takes 70 subjects with simple gingivitis problem as test objects, and adopts a method of oral epidemiological investigation to check the change condition that all teeth of the subjects are full-mouth 12 weeks before and after 2 kinds of toothpaste (code numbers are A, C respectively), each tooth has 4 sites (cheek side near middle, center, far middle 3 sites and tongue side center) Gingival Index (GI), and the site with bleeding after probing accounts for the percentage (BOP%) of the total sites of the full mouth.

(5) And (3) test results: after 12 weeks of use of toothpaste a, the subject's mean GI rose from 1.61 to 1.81, a 12.1% rise from baseline; BOP% decreased from 8.24% to 1.94% of baseline value by 76.5%; after 12 weeks of C toothpaste use, the subject's mean GI rose from 1.47 to 1.73, 18.2% of baseline; BOP% was reduced from 4.74% to 1.25% of baseline by 73.7%.

(6) The experiment conclusion shows that the BOP% of the subjects using the toothpaste A is obviously improved compared with the subjects using the toothpaste C, namely the gingival inflammation bleeding index, and the toothpaste A has obvious effect of improving the gingival bleeding. At the end of the test, toothpaste a was the fire-fighting toothpaste prepared in example 5 and toothpaste C was a blank toothpaste without any drug.

(7) And (3) setting a clinical test:

aim-through the clinical use of the toothpaste for 3 months, the efficacy of the toothpaste A for improving the gingival bleeding is observed.

Data and method

Indications: simple gingivitis;

selection criteria: healthy, no systemic disease, agreeing to accept the use of test toothpaste and agreeing to match the examinee on time; (iii) having simple gingivitis; promise to keep using the oral hygiene measures provided daily during the trial, without using other toothpastes; normal blood, normal platelet and bleeding time.

Exclusion criteria: there is a history of allergies to oral hygiene products; acute inflammation, gestational gingivitis, gingival hyperplasia; antibiotics were used one month prior to study participation.

The method comprises the following steps: according to the design of a random double-blind control experiment, subjects are all aged 17-57 years, and the subjects are randomly divided into a control group and a test group. All gingivitis related indices were examined and recorded throughout the mouth at baseline, 4 weeks and 12 weeks after toothpaste use, 4 sites per tooth (buccal mesial, central, distal 3 sites and lingual central).

The number of cases: control group: 35 cases; experimental groups: in 35 cases.

Sources of toothpaste and toothbrush:

toothpaste:

provided by Guangzhou Yuehang industries, Inc., is a paste, has consistent appearance marks and is respectively marked with A, C characters;

toothbrush: lion king fine tooth cleaning toothbrush.

The using method comprises the following steps:

dosage: the subjects in the experimental group and the control group brush teeth 2 times in the morning and at the evening each time, and use 2 g of toothpaste each time.

The course of treatment is as follows: for 12 weeks.

Observation items and indexes:

the clinical observation indexes are as follows:

gingival Index (GI): 1: no inflammation; 2: mild inflammation, slight change in gum color and texture; 3: moderate inflammation, bright gum, redness, swelling, hyperplasia; 4: severe inflammation, marked redness, hyperplasia of gum and spontaneous bleeding.

BOP%: the percentage of sites with bleeding after probing to the total sites of the whole mouth

Adverse reactions: after the toothpaste is used, whether allergy, irritation reaction, nausea and other adverse reactions exist or not is observed; mouthfeel, taste, degree of tolerance.

The clinical observation indexes before and after the toothpaste is used are finished by the examination of a doctor.

Statistical method-

Compared with the gingival indexes and BOP percent indexes of two groups of subjects, when the gingival index meets (a control test)/the control is more than or equal to 15 percent, the product has the efficacies of relieving gingival inflammation and improving gingival bleeding.

Results-

The test time is 1 month to 4 months from 2021 year to 2021 year, and 70 subjects complete the whole observation, wherein 35 persons in group A and 35 persons in group C; male 32, female 38.

Changes in periodontal index before and after toothpaste use in two groups of subjects:

comparison of GI before and after toothpaste application in two groups of subjects

Before using toothpaste A, the baseline value of the mean GI of the teeth of the subjects in group A is 1.61, and after using toothpaste A for 4 weeks, the mean GI of the teeth rises to 1.74 and rises to 37.8 percent; after 12 weeks of use of toothpaste A, the GI rise was 1.81 for the mean tooth and 12.1% for the mean tooth. Before C toothpaste was used, the baseline value of the mean GI of the teeth of the subjects in group C was 1.47, and 4 weeks after C toothpaste was used, the mean GI of the teeth rose to 1.66, which rose by 48.4%; after 12 weeks of use of toothpaste C, the GI rise was 1.73 for the mean tooth and 18.2% for the mean tooth.

Comparison of BOP% before and after toothpaste application in two groups of subjects

Before using toothpaste a, the baseline value of BOP% for group a subjects was 8.24%, and after 4 weeks using toothpaste a, BOP% decreased by 5.13%, by 37.8%; after 12 weeks of use with toothpaste A, the BOP% drop was 1.94%, a 76.5% drop. Before C toothpaste was used, the baseline value for BOP% in group C subjects was 4.74%, and after 4 weeks of C toothpaste use, BOP% decreased by 2.45%, 48.4%; after 12 weeks of use of C toothpaste, the BOP% drop was 1.25%, a 73.7% drop.

After two groups of testees respectively use the toothpaste, no adverse reaction occurs, and the mouthfeel is good.

Conclusion-

By double-blind random test, A, C toothpaste has no adverse reaction. The BOP% of the subjects using the toothpaste A group was significantly improved compared with the subjects using the toothpaste C group, i.e., the gingival inflammatory bleeding index, indicating that the toothpaste A had a significant efficacy in improving gingival bleeding.

At the end of the test, toothpaste a was the fire-fighting toothpaste prepared in example 5 of the present application, and toothpaste C was a blank toothpaste without any drug.

Remarking: the symptoms of oral cavity internal heat are: gingival inflammation (including inflammation, swelling and pain, etc.), gingival bleeding, oral ulcer, etc.

The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and substitutions can be made without departing from the technical principle of the present invention, and these modifications and substitutions should also be regarded as the protection scope of the present invention.

Claims

1. The fire-proof toothpaste is characterized by being prepared from the following components in percentage by weight:

the balance being water.

2. The fire protection toothpaste according to claim 1,

the composition is prepared from the following components in percentage by weight:

the balance being water.

3. The fire-fighting toothpaste according to claim 2, wherein:

the balance being water.

4. The excessive internal heat preventing toothpaste according to claim 3, wherein:

the PEG-400 is purchased from Jinan crystal Hao chemical Co., Ltd, and the model number is TS 7;

5. the excessive internal heat preventing toothpaste according to claim 3, wherein:

the Qingyan salt is purchased from Qinghai Yingjude commercial and trade company Limited and has the model number of 418423;

6. The excessive internal heat preventing toothpaste according to claim 3, wherein:

the essence is purchased from Chengdu Vientis Hongrun Biotechnology Co., Ltd, and has the model number DJ-4345;

7. The excessive internal heat preventing toothpaste according to claim 3, wherein:

the almond extract is purchased from Hibiscus ventilation Biotech, Inc. with the model number TLC-1010;

8. The preparation method of the internal heat preventing toothpaste is characterized by comprising the following steps:

the method comprises the following steps:

(7) and (5) obtaining paste after the detection is qualified.

9. The method for preparing the toothpaste for preventing excessive internal heat according to claim 8, wherein:

adding sodium monofluorophosphate according to the formula amount, wherein the amount of the sodium monofluorophosphate is 2 times of the amount of the sodium benzoate;

10. The method for preparing the toothpaste for preventing excessive internal heat according to claim 8, wherein:

and (5) weighing sodium lauroyl sarcosine according to the formula amount, wherein the dosage of the sodium lauroyl sarcosine is 3 times of that of the essence.