CN113302294A - 具有木聚糖酶活性的多肽及其用于改善动物饲料营养质量的用途 - Google Patents

具有木聚糖酶活性的多肽及其用于改善动物饲料营养质量的用途 Download PDF

Info

Publication number: CN113302294A
Authority: CN; China
Prior art keywords: seq; polypeptide; xylanase; amino acids; alpha
Prior art date: 2019-01-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN202080009202.6A

Other languages

English (en)

Chinese (zh)

Inventor

J·弗里克曼

K·詹森

E·弗拉森科

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novozymes AS

Original Assignee

Novozymes AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-01-31

Filing date

2020-01-29

Publication date

2021-08-24

2020-01-29 Application filed by Novozymes AS filed Critical Novozymes AS

2021-08-24 Publication of CN113302294A publication Critical patent/CN113302294A/zh

Status Pending legal-status Critical Current

Links

108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 472
229920001184 polypeptide Polymers 0.000 title claims abstract description 470
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 470
101710121765 Endo-1,4-beta-xylanase Proteins 0.000 title claims abstract description 291
230000000694 effects Effects 0.000 title claims abstract description 100
235000016709 nutrition Nutrition 0.000 title claims abstract description 18
241001465754 Metazoa Species 0.000 title claims description 39
239000000203 mixture Substances 0.000 claims abstract description 311
102000004190 Enzymes Human genes 0.000 claims abstract description 190
108090000790 Enzymes Proteins 0.000 claims abstract description 190
238000000034 method Methods 0.000 claims abstract description 164
238000000855 fermentation Methods 0.000 claims abstract description 138
230000004151 fermentation Effects 0.000 claims abstract description 138
102000040430 polynucleotide Human genes 0.000 claims abstract description 107
108091033319 polynucleotide Proteins 0.000 claims abstract description 107
239000002157 polynucleotide Substances 0.000 claims abstract description 107
239000000047 product Substances 0.000 claims abstract description 85
238000004519 manufacturing process Methods 0.000 claims abstract description 40
150000007523 nucleic acids Chemical class 0.000 claims abstract description 28
102000039446 nucleic acids Human genes 0.000 claims abstract description 27
108020004707 nucleic acids Proteins 0.000 claims abstract description 27
239000006227 byproduct Substances 0.000 claims abstract description 17
230000001461 cytolytic effect Effects 0.000 claims description 210
229940088598 enzyme Drugs 0.000 claims description 182
150000001413 amino acids Chemical class 0.000 claims description 175
108090000637 alpha-Amylases Proteins 0.000 claims description 112
102000004139 alpha-Amylases Human genes 0.000 claims description 105
229940024171 alpha-amylase Drugs 0.000 claims description 96
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 81
230000008569 process Effects 0.000 claims description 59
239000000463 material Substances 0.000 claims description 54
108091026890 Coding region Proteins 0.000 claims description 52
229920002472 Starch Polymers 0.000 claims description 44
239000008107 starch Substances 0.000 claims description 44
235000019698 starch Nutrition 0.000 claims description 44
239000012634 fragment Substances 0.000 claims description 35
102100022624 Glucoamylase Human genes 0.000 claims description 33
108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims description 31
235000013339 cereals Nutrition 0.000 claims description 28
240000008042 Zea mays Species 0.000 claims description 22
235000002017 Zea mays subsp mays Nutrition 0.000 claims description 22
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 16
235000005822 corn Nutrition 0.000 claims description 16
238000001035 drying Methods 0.000 claims description 13
239000013604 expression vector Substances 0.000 claims description 12
230000000295 complement effect Effects 0.000 claims description 10
230000001965 increasing effect Effects 0.000 claims description 8
235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 claims description 6
235000009973 maize Nutrition 0.000 claims description 6
238000003259 recombinant expression Methods 0.000 claims description 6
230000002503 metabolic effect Effects 0.000 claims description 5
240000005979 Hordeum vulgare Species 0.000 claims description 4
235000007340 Hordeum vulgare Nutrition 0.000 claims description 4
240000006394 Sorghum bicolor Species 0.000 claims description 4
235000011684 Sorghum saccharatum Nutrition 0.000 claims description 4
244000062793 Sorghum vulgare Species 0.000 claims description 4
235000021307 Triticum Nutrition 0.000 claims description 4
238000012258 culturing Methods 0.000 claims description 4
235000019713 millet Nutrition 0.000 claims description 4
241000209056 Secale Species 0.000 claims description 3
235000007238 Secale cereale Nutrition 0.000 claims description 3
241001520808 Panicum virgatum Species 0.000 claims description 2
244000115721 Pennisetum typhoides Species 0.000 claims description 2
235000007195 Pennisetum typhoides Nutrition 0.000 claims description 2
235000008515 Setaria glauca Nutrition 0.000 claims description 2
235000019714 Triticale Nutrition 0.000 claims description 2
125000003158 alcohol group Chemical group 0.000 claims description 2
239000000446 fuel Substances 0.000 claims description 2
241000228158 x Triticosecale Species 0.000 claims description 2
101710089042 Demethyl-4-deoxygadusol synthase Proteins 0.000 claims 3
244000098338 Triticum aestivum Species 0.000 claims 1
239000013598 vector Substances 0.000 abstract description 34
235000001014 amino acid Nutrition 0.000 description 187
229940024606 amino acid Drugs 0.000 description 174
210000004027 cell Anatomy 0.000 description 105
125000003275 alpha amino acid group Chemical group 0.000 description 104
108010008885 Cellulose 1,4-beta-Cellobiosidase Proteins 0.000 description 92
102000006995 beta-Glucosidase Human genes 0.000 description 79
108010047754 beta-Glucosidase Proteins 0.000 description 79
238000006467 substitution reaction Methods 0.000 description 63
108010059892 Cellulase Proteins 0.000 description 61
108090000623 proteins and genes Proteins 0.000 description 58
241001225321 Aspergillus fumigatus Species 0.000 description 51
229940091771 aspergillus fumigatus Drugs 0.000 description 51
108020004414 DNA Proteins 0.000 description 50
230000002708 enhancing effect Effects 0.000 description 49
108010076504 Protein Sorting Signals Proteins 0.000 description 44
238000012217 deletion Methods 0.000 description 43
230000037430 deletion Effects 0.000 description 43
241000193830 Bacillus <bacterium> Species 0.000 description 40
239000002773 nucleotide Substances 0.000 description 37
125000003729 nucleotide group Chemical group 0.000 description 37
241000499912 Trichoderma reesei Species 0.000 description 28
102000004169 proteins and genes Human genes 0.000 description 28
241000959173 Rasamsonia emersonii Species 0.000 description 27
230000001580 bacterial effect Effects 0.000 description 27
241000193385 Geobacillus stearothermophilus Species 0.000 description 26
108010002430 hemicellulase Proteins 0.000 description 26
238000003780 insertion Methods 0.000 description 26
230000037431 insertion Effects 0.000 description 26
235000018102 proteins Nutrition 0.000 description 26
108020004711 Nucleic Acid Probes Proteins 0.000 description 25
239000002853 nucleic acid probe Substances 0.000 description 25
244000005700 microbiome Species 0.000 description 23
235000015097 nutrients Nutrition 0.000 description 23
239000000523 sample Substances 0.000 description 22
241000179039 Paenibacillus Species 0.000 description 21
229920002678 cellulose Polymers 0.000 description 21
239000001913 cellulose Substances 0.000 description 21
235000010980 cellulose Nutrition 0.000 description 21
239000000758 substrate Substances 0.000 description 21
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 20
102000035195 Peptidases Human genes 0.000 description 20
108091005804 Peptidases Proteins 0.000 description 20
239000004365 Protease Substances 0.000 description 19
229940059442 hemicellulase Drugs 0.000 description 19
239000002002 slurry Substances 0.000 description 18
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 17
241001467578 Microbacterium Species 0.000 description 17
240000004808 Saccharomyces cerevisiae Species 0.000 description 17
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 17
239000000835 fiber Substances 0.000 description 17
240000006439 Aspergillus oryzae Species 0.000 description 16
235000002247 Aspergillus oryzae Nutrition 0.000 description 16
241000228341 Talaromyces Species 0.000 description 16
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 16
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 16
230000004927 fusion Effects 0.000 description 16
102220035153 rs199475972 Human genes 0.000 description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
239000001110 calcium chloride Substances 0.000 description 15
229910001628 calcium chloride Inorganic materials 0.000 description 15
239000002299 complementary DNA Substances 0.000 description 15
238000006460 hydrolysis reaction Methods 0.000 description 15
102220640696 Protein PAT1 homolog 2_F100D_mutation Human genes 0.000 description 14
235000019621 digestibility Nutrition 0.000 description 14
230000007062 hydrolysis Effects 0.000 description 14
230000010076 replication Effects 0.000 description 14
241000228212 Aspergillus Species 0.000 description 13
-1 for example Proteins 0.000 description 13
241000228245 Aspergillus niger Species 0.000 description 12
244000063299 Bacillus subtilis Species 0.000 description 12
102000005744 Glycoside Hydrolases Human genes 0.000 description 12
108010031186 Glycoside Hydrolases Proteins 0.000 description 12
241000228143 Penicillium Species 0.000 description 12
235000000346 sugar Nutrition 0.000 description 12
235000014469 Bacillus subtilis Nutrition 0.000 description 11
125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 description 11
241001633954 Microbacterium oxydans Species 0.000 description 11
241000985513 Penicillium oxalicum Species 0.000 description 11
210000004899 c-terminal region Anatomy 0.000 description 11
239000007788 liquid Substances 0.000 description 11
229920002704 polyhistidine Polymers 0.000 description 11
238000011160 research Methods 0.000 description 11
239000000126 substance Substances 0.000 description 11
241000194108 Bacillus licheniformis Species 0.000 description 10
241000223259 Trichoderma Species 0.000 description 10
125000000539 amino acid group Chemical group 0.000 description 10
150000001720 carbohydrates Chemical class 0.000 description 10
235000014633 carbohydrates Nutrition 0.000 description 10
239000002609 medium Substances 0.000 description 10
230000035772 mutation Effects 0.000 description 10
150000007524 organic acids Chemical class 0.000 description 10
239000013612 plasmid Substances 0.000 description 10
238000000926 separation method Methods 0.000 description 10
239000007787 solid Substances 0.000 description 10
241000894007 species Species 0.000 description 10
241000588724 Escherichia coli Species 0.000 description 9
102100029677 Trehalase Human genes 0.000 description 9
108010087472 Trehalase Proteins 0.000 description 9
210000001035 gastrointestinal tract Anatomy 0.000 description 9
102200086056 rs41494349 Human genes 0.000 description 9
241000228197 Aspergillus flavus Species 0.000 description 8
241000894006 Bacteria Species 0.000 description 8
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 8
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 8
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 8
238000003556 assay Methods 0.000 description 8
229940106157 cellulase Drugs 0.000 description 8
238000006243 chemical reaction Methods 0.000 description 8
229920001221 xylan Polymers 0.000 description 8
241000193744 Bacillus amyloliquefaciens Species 0.000 description 7
241000433763 Microbacterium hydrocarbonoxydans Species 0.000 description 7
241000228182 Thermoascus aurantiacus Species 0.000 description 7
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 7
238000009472 formulation Methods 0.000 description 7
230000006870 function Effects 0.000 description 7
230000002538 fungal effect Effects 0.000 description 7
239000003550 marker Substances 0.000 description 7
238000002844 melting Methods 0.000 description 7
230000008018 melting Effects 0.000 description 7
238000003752 polymerase chain reaction Methods 0.000 description 7
238000012216 screening Methods 0.000 description 7
235000002639 sodium chloride Nutrition 0.000 description 7
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
241001328122 Bacillus clausii Species 0.000 description 6
102000005575 Cellulases Human genes 0.000 description 6
108010084185 Cellulases Proteins 0.000 description 6
101710098247 Exoglucanase 1 Proteins 0.000 description 6
239000004471 Glycine Substances 0.000 description 6
241000857964 Ileodictyon cibarium Species 0.000 description 6
238000002105 Southern blotting Methods 0.000 description 6
241001495429 Thielavia terrestris Species 0.000 description 6
PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 6
229910052799 carbon Inorganic materials 0.000 description 6
238000005119 centrifugation Methods 0.000 description 6
238000000354 decomposition reaction Methods 0.000 description 6
238000004821 distillation Methods 0.000 description 6
238000009396 hybridization Methods 0.000 description 6
238000005259 measurement Methods 0.000 description 6
108020004999 messenger RNA Proteins 0.000 description 6
230000000813 microbial effect Effects 0.000 description 6
238000000746 purification Methods 0.000 description 6
230000028327 secretion Effects 0.000 description 6
210000002966 serum Anatomy 0.000 description 6
150000008163 sugars Chemical class 0.000 description 6
238000013518 transcription Methods 0.000 description 6
230000035897 transcription Effects 0.000 description 6
230000014616 translation Effects 0.000 description 6
150000004823 xylans Chemical class 0.000 description 6
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
241000972773 Aulopiformes Species 0.000 description 5
241000606125 Bacteroides Species 0.000 description 5
108090000371 Esterases Proteins 0.000 description 5
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
102000004157 Hydrolases Human genes 0.000 description 5
108090000604 Hydrolases Proteins 0.000 description 5
244000285963 Kluyveromyces fragilis Species 0.000 description 5
235000014663 Kluyveromyces fragilis Nutrition 0.000 description 5
241000058353 Paenibacillus terrae Species 0.000 description 5
241000282849 Ruminantia Species 0.000 description 5
241000215642 Trichophaea Species 0.000 description 5
239000003674 animal food additive Substances 0.000 description 5
238000003776 cleavage reaction Methods 0.000 description 5
238000001704 evaporation Methods 0.000 description 5
230000008020 evaporation Effects 0.000 description 5
239000008103 glucose Substances 0.000 description 5
238000011534 incubation Methods 0.000 description 5
239000003921 oil Substances 0.000 description 5
235000019515 salmon Nutrition 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
230000007017 scission Effects 0.000 description 5
230000007928 solubilization Effects 0.000 description 5
238000005063 solubilization Methods 0.000 description 5
230000003381 solubilizing effect Effects 0.000 description 5
108010011619 6-Phytase Proteins 0.000 description 4
241000251468 Actinopterygii Species 0.000 description 4
239000004475 Arginine Substances 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
108010029675 Bacillus licheniformis alpha-amylase Proteins 0.000 description 4
241000222120 Candida <Saccharomycetales> Species 0.000 description 4
241000123346 Chrysosporium Species 0.000 description 4
241001674013 Chrysosporium lucknowense Species 0.000 description 4
241000790338 Dictyococcus Species 0.000 description 4
241000196324 Embryophyta Species 0.000 description 4
101710098246 Exoglucanase 2 Proteins 0.000 description 4
241000223198 Humicola Species 0.000 description 4
241001480714 Humicola insolens Species 0.000 description 4
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 4
240000003183 Manihot esculenta Species 0.000 description 4
235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 4
241001655310 Microbacteriaceae Species 0.000 description 4
240000007594 Oryza sativa Species 0.000 description 4
235000007164 Oryza sativa Nutrition 0.000 description 4
241000235648 Pichia Species 0.000 description 4
241000235525 Rhizomucor pusillus Species 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
241000187747 Streptomyces Species 0.000 description 4
235000004279 alanine Nutrition 0.000 description 4
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 4
235000013405 beer Nutrition 0.000 description 4
230000015556 catabolic process Effects 0.000 description 4
239000002361 compost Substances 0.000 description 4
238000010411 cooking Methods 0.000 description 4
ZINJLDJMHCUBIP-UHFFFAOYSA-N ethametsulfuron-methyl Chemical compound CCOC1=NC(NC)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)C(=O)OC)=N1 ZINJLDJMHCUBIP-UHFFFAOYSA-N 0.000 description 4
210000003608 fece Anatomy 0.000 description 4
235000019688 fish Nutrition 0.000 description 4
108020001507 fusion proteins Proteins 0.000 description 4
102000037865 fusion proteins Human genes 0.000 description 4
235000013922 glutamic acid Nutrition 0.000 description 4
239000004220 glutamic acid Substances 0.000 description 4
125000003147 glycosyl group Chemical group 0.000 description 4
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 4
230000010354 integration Effects 0.000 description 4
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
244000144977 poultry Species 0.000 description 4
235000013594 poultry meat Nutrition 0.000 description 4
235000009566 rice Nutrition 0.000 description 4
239000002689 soil Substances 0.000 description 4
230000009466 transformation Effects 0.000 description 4
238000013519 translation Methods 0.000 description 4
235000019786 weight gain Nutrition 0.000 description 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
229920000936 Agarose Polymers 0.000 description 3
239000004382 Amylase Substances 0.000 description 3
108090001008 Avidin Proteins 0.000 description 3
229920002498 Beta-glucan Polymers 0.000 description 3
102100032487 Beta-mannosidase Human genes 0.000 description 3
241000283690 Bos taurus Species 0.000 description 3
241000193403 Clostridium Species 0.000 description 3
241000222511 Coprinus Species 0.000 description 3
239000003298 DNA probe Substances 0.000 description 3
102000010911 Enzyme Precursors Human genes 0.000 description 3
108010062466 Enzyme Precursors Proteins 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
241000287828 Gallus gallus Species 0.000 description 3
241000626621 Geobacillus Species 0.000 description 3
241001492300 Gloeophyllum trabeum Species 0.000 description 3
229920001503 Glucan Polymers 0.000 description 3
229920002488 Hemicellulose Polymers 0.000 description 3
102100031415 Hepatic triacylglycerol lipase Human genes 0.000 description 3
125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 description 3
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 3
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 3
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
108010029541 Laccase Proteins 0.000 description 3
108090001060 Lipase Proteins 0.000 description 3
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
239000004472 Lysine Substances 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
102220508063 Mitochondrial folate transporter/carrier_G91R_mutation Human genes 0.000 description 3
241000235388 Mucorales Species 0.000 description 3
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 3
239000000020 Nitrocellulose Substances 0.000 description 3
241001112734 Paenibacillaceae Species 0.000 description 3
241000985550 Penicillium capsulatum Species 0.000 description 3
241000589516 Pseudomonas Species 0.000 description 3
108020004518 RNA Probes Proteins 0.000 description 3
239000003391 RNA probe Substances 0.000 description 3
241000235070 Saccharomyces Species 0.000 description 3
241000277331 Salmonidae Species 0.000 description 3
241000235060 Scheffersomyces stipitis Species 0.000 description 3
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
241000282887 Suidae Species 0.000 description 3
241001494489 Thielavia Species 0.000 description 3
241000209140 Triticum Species 0.000 description 3
102220604077 Uncharacterized protein C12orf71_I140V_mutation Human genes 0.000 description 3
239000002253 acid Substances 0.000 description 3
238000000246 agarose gel electrophoresis Methods 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
108010055059 beta-Mannosidase Proteins 0.000 description 3
229960002685 biotin Drugs 0.000 description 3
235000020958 biotin Nutrition 0.000 description 3
239000011616 biotin Substances 0.000 description 3
239000012876 carrier material Substances 0.000 description 3
230000003197 catalytic effect Effects 0.000 description 3
239000006143 cell culture medium Substances 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
238000004587 chromatography analysis Methods 0.000 description 3
230000002759 chromosomal effect Effects 0.000 description 3
210000000349 chromosome Anatomy 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
238000006731 degradation reaction Methods 0.000 description 3
238000013461 design Methods 0.000 description 3
238000001514 detection method Methods 0.000 description 3
238000009837 dry grinding Methods 0.000 description 3
230000009977 dual effect Effects 0.000 description 3
108010038658 exo-1,4-beta-D-xylosidase Proteins 0.000 description 3
238000002744 homologous recombination Methods 0.000 description 3
230000006801 homologous recombination Effects 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
238000002955 isolation Methods 0.000 description 3
238000011068 loading method Methods 0.000 description 3
239000011159 matrix material Substances 0.000 description 3
229920001220 nitrocellulos Polymers 0.000 description 3
150000002482 oligosaccharides Chemical class 0.000 description 3
235000005985 organic acids Nutrition 0.000 description 3
239000000123 paper Substances 0.000 description 3
229940085127 phytase Drugs 0.000 description 3
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
238000012545 processing Methods 0.000 description 3
210000001938 protoplast Anatomy 0.000 description 3
238000011084 recovery Methods 0.000 description 3
239000001632 sodium acetate Substances 0.000 description 3
235000017281 sodium acetate Nutrition 0.000 description 3
239000000243 solution Substances 0.000 description 3
239000007858 starting material Substances 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
230000002103 transcriptional effect Effects 0.000 description 3
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 3
238000011144 upstream manufacturing Methods 0.000 description 3
239000011782 vitamin Substances 0.000 description 3
235000013343 vitamin Nutrition 0.000 description 3
229940088594 vitamin Drugs 0.000 description 3
229930003231 vitamin Natural products 0.000 description 3
230000004584 weight gain Effects 0.000 description 3
CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
AXMJGXMRGDCRND-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)cyclohexyl]oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1CCC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)CC1 AXMJGXMRGDCRND-UHFFFAOYSA-N 0.000 description 2
IFBHRQDFSNCLOZ-RMPHRYRLSA-N 4-nitrophenyl beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C([N+]([O-])=O)C=C1 IFBHRQDFSNCLOZ-RMPHRYRLSA-N 0.000 description 2
102000013142 Amylases Human genes 0.000 description 2
108010065511 Amylases Proteins 0.000 description 2
241001112741 Bacillaceae Species 0.000 description 2
241000193833 Bacillales Species 0.000 description 2
108700003918 Bacillus Thuringiensis insecticidal crystal Proteins 0.000 description 2
101000775727 Bacillus amyloliquefaciens Alpha-amylase Proteins 0.000 description 2
241000193752 Bacillus circulans Species 0.000 description 2
241000193747 Bacillus firmus Species 0.000 description 2
241000193422 Bacillus lentus Species 0.000 description 2
101000695691 Bacillus licheniformis Beta-lactamase Proteins 0.000 description 2
241000194107 Bacillus megaterium Species 0.000 description 2
241000194103 Bacillus pumilus Species 0.000 description 2
108091005658 Basic proteases Proteins 0.000 description 2
239000002028 Biomass Substances 0.000 description 2
241000193764 Brevibacillus brevis Species 0.000 description 2
125000001433 C-terminal amino-acid group Chemical group 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
241000589876 Campylobacter Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
241000863387 Cellvibrio Species 0.000 description 2
DBPRUZCKPFOVDV-UHFFFAOYSA-N Clorprenaline hydrochloride Chemical compound O.Cl.CC(C)NCC(O)C1=CC=CC=C1Cl DBPRUZCKPFOVDV-UHFFFAOYSA-N 0.000 description 2
108020004705 Codon Proteins 0.000 description 2
244000228088 Cola acuminata Species 0.000 description 2
235000010205 Cola acuminata Nutrition 0.000 description 2
235000015438 Cola nitida Nutrition 0.000 description 2
241000252233 Cyprinus carpio Species 0.000 description 2
241000863004 Cystobacter Species 0.000 description 2
GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
102000053602 DNA Human genes 0.000 description 2
241000238557 Decapoda Species 0.000 description 2
108010001817 Endo-1,4-beta Xylanases Proteins 0.000 description 2
241000589565 Flavobacterium Species 0.000 description 2
241000233866 Fungi Species 0.000 description 2
101100369308 Geobacillus stearothermophilus nprS gene Proteins 0.000 description 2
101100080316 Geobacillus stearothermophilus nprT gene Proteins 0.000 description 2
241000159512 Geotrichum Species 0.000 description 2
241000123332 Gloeophyllum Species 0.000 description 2
241000123313 Gloeophyllum sepiarium Species 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
102220466851 HLA class II histocompatibility antigen, DR beta 4 chain_V59A_mutation Human genes 0.000 description 2
244000286779 Hansenula anomala Species 0.000 description 2
235000014683 Hansenula anomala Nutrition 0.000 description 2
241000589989 Helicobacter Species 0.000 description 2
241000235649 Kluyveromyces Species 0.000 description 2
241000235058 Komagataella pastoris Species 0.000 description 2
125000003440 L-leucyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 description 2
125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 description 2
241000218187 Lachnum Species 0.000 description 2
241000442132 Lactarius lactarius Species 0.000 description 2
102000004882 Lipase Human genes 0.000 description 2
239000004367 Lipase Substances 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
108010054377 Mannosidases Proteins 0.000 description 2
102000001696 Mannosidases Human genes 0.000 description 2
241001143352 Meloidogyne Species 0.000 description 2
241000187708 Micromonospora Species 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
241000588653 Neisseria Species 0.000 description 2
241000320412 Ogataea angusta Species 0.000 description 2
102000004316 Oxidoreductases Human genes 0.000 description 2
108090000854 Oxidoreductases Proteins 0.000 description 2
241000194109 Paenibacillus lautus Species 0.000 description 2
241000301638 Paenibacillus terreus Species 0.000 description 2
102100026367 Pancreatic alpha-amylase Human genes 0.000 description 2
ZRWPUFFVAOMMNM-UHFFFAOYSA-N Patulin Chemical compound OC1OCC=C2OC(=O)C=C12 ZRWPUFFVAOMMNM-UHFFFAOYSA-N 0.000 description 2
102000003992 Peroxidases Human genes 0.000 description 2
102000015439 Phospholipases Human genes 0.000 description 2
108010064785 Phospholipases Proteins 0.000 description 2
241000861914 Plecoglossus altivelis Species 0.000 description 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
241000678519 Rasamsonia Species 0.000 description 2
108020004511 Recombinant DNA Proteins 0.000 description 2
241000235403 Rhizomucor miehei Species 0.000 description 2
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
241000192031 Ruminococcus Species 0.000 description 2
235000018368 Saccharomyces fragilis Nutrition 0.000 description 2
241000582914 Saccharomyces uvarum Species 0.000 description 2
241000607142 Salmonella Species 0.000 description 2
241000235346 Schizosaccharomyces Species 0.000 description 2
241000235347 Schizosaccharomyces pombe Species 0.000 description 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
241000607720 Serratia Species 0.000 description 2
102220606457 Sorting nexin-10_L89M_mutation Human genes 0.000 description 2
241000194017 Streptococcus Species 0.000 description 2
241000282898 Sus scrofa Species 0.000 description 2
239000004098 Tetracycline Substances 0.000 description 2
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
239000004473 Threonine Substances 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
241001660006 Verrucosispora Species 0.000 description 2
241000589634 Xanthomonas Species 0.000 description 2
235000011054 acetic acid Nutrition 0.000 description 2
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 2
108010093941 acetylxylan esterase Proteins 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
235000015107 ale Nutrition 0.000 description 2
108010030291 alpha-Galactosidase Proteins 0.000 description 2
102000005840 alpha-Galactosidase Human genes 0.000 description 2
230000004075 alteration Effects 0.000 description 2
230000003321 amplification Effects 0.000 description 2
235000019418 amylase Nutrition 0.000 description 2
229920000617 arabinoxylan Polymers 0.000 description 2
229940005348 bacillus firmus Drugs 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
108010005774 beta-Galactosidase Proteins 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
244000309466 calf Species 0.000 description 2
241001233037 catfish Species 0.000 description 2
230000022534 cell killing Effects 0.000 description 2
239000013592 cell lysate Substances 0.000 description 2
210000002421 cell wall Anatomy 0.000 description 2
108010080434 cephalosporin-C deacetylase Proteins 0.000 description 2
235000013330 chicken meat Nutrition 0.000 description 2
238000010367 cloning Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
235000008504 concentrate Nutrition 0.000 description 2
235000013365 dairy product Nutrition 0.000 description 2
238000000113 differential scanning calorimetry Methods 0.000 description 2
239000006047 digesta Substances 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
230000035622 drinking Effects 0.000 description 2
238000007876 drug discovery Methods 0.000 description 2
238000004520 electroporation Methods 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
230000007613 environmental effect Effects 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
239000003797 essential amino acid Substances 0.000 description 2
235000020776 essential amino acid Nutrition 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000001914 filtration Methods 0.000 description 2
235000013305 food Nutrition 0.000 description 2
230000002431 foraging effect Effects 0.000 description 2
239000007789 gas Substances 0.000 description 2
108010061330 glucan 1,4-alpha-maltohydrolase Proteins 0.000 description 2
239000008187 granular material Substances 0.000 description 2
238000000227 grinding Methods 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
230000002573 hemicellulolytic effect Effects 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
210000003405 ileum Anatomy 0.000 description 2
230000006872 improvement Effects 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
230000017730 intein-mediated protein splicing Effects 0.000 description 2
FGKJLKRYENPLQH-UHFFFAOYSA-N isocaproic acid Chemical compound CC(C)CCC(O)=O FGKJLKRYENPLQH-UHFFFAOYSA-N 0.000 description 2
229940031154 kluyveromyces marxianus Drugs 0.000 description 2
239000004310 lactic acid Substances 0.000 description 2
235000014655 lactic acid Nutrition 0.000 description 2
238000007834 ligase chain reaction Methods 0.000 description 2
235000019421 lipase Nutrition 0.000 description 2
235000012054 meals Nutrition 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 2
230000002906 microbiologic effect Effects 0.000 description 2
238000003801 milling Methods 0.000 description 2
235000010755 mineral Nutrition 0.000 description 2
239000011707 mineral Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
238000002703 mutagenesis Methods 0.000 description 2
231100000350 mutagenesis Toxicity 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
238000003199 nucleic acid amplification method Methods 0.000 description 2
229920001542 oligosaccharide Polymers 0.000 description 2
230000037361 pathway Effects 0.000 description 2
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
229920001282 polysaccharide Polymers 0.000 description 2
239000005017 polysaccharide Substances 0.000 description 2
150000004804 polysaccharides Chemical class 0.000 description 2
230000004481 post-translational protein modification Effects 0.000 description 2
239000004302 potassium sorbate Substances 0.000 description 2
235000010241 potassium sorbate Nutrition 0.000 description 2
229940069338 potassium sorbate Drugs 0.000 description 2
YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 2
238000001243 protein synthesis Methods 0.000 description 2
230000006798 recombination Effects 0.000 description 2
238000005215 recombination Methods 0.000 description 2
230000003362 replicative effect Effects 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
238000012552 review Methods 0.000 description 2
230000003248 secreting effect Effects 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000001509 sodium citrate Substances 0.000 description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
229960002180 tetracycline Drugs 0.000 description 2
229930101283 tetracycline Natural products 0.000 description 2
235000019364 tetracycline Nutrition 0.000 description 2
150000003522 tetracyclines Chemical class 0.000 description 2
238000001238 wet grinding Methods 0.000 description 2
OCUSNPIJIZCRSZ-ZTZWCFDHSA-N (2s)-2-amino-3-methylbutanoic acid;(2s)-2-amino-4-methylpentanoic acid;(2s,3s)-2-amino-3-methylpentanoic acid Chemical compound CC(C)[C@H](N)C(O)=O.CC[C@H](C)[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O OCUSNPIJIZCRSZ-ZTZWCFDHSA-N 0.000 description 1
FYGDTMLNYKFZSV-WFYNLLPOSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,3s,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-WFYNLLPOSA-N 0.000 description 1
108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 description 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
BTJIUGUIPKRLHP-UHFFFAOYSA-M 4-nitrophenolate Chemical compound [O-]C1=CC=C([N+]([O-])=O)C=C1 BTJIUGUIPKRLHP-UHFFFAOYSA-M 0.000 description 1
241001519451 Abramis brama Species 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
241000186361 Actinobacteria <class> Species 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
239000005995 Aluminium silicate Substances 0.000 description 1
108090000915 Aminopeptidases Proteins 0.000 description 1
102000004400 Aminopeptidases Human genes 0.000 description 1
241000252073 Anguilliformes Species 0.000 description 1
235000002198 Annona diversifolia Nutrition 0.000 description 1
241000272517 Anseriformes Species 0.000 description 1
101710152845 Arabinogalactan endo-beta-1,4-galactanase Proteins 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
102000035101 Aspartic proteases Human genes 0.000 description 1
108091005502 Aspartic proteases Proteins 0.000 description 1
101001065065 Aspergillus awamori Feruloyl esterase A Proteins 0.000 description 1
101000757144 Aspergillus niger Glucoamylase Proteins 0.000 description 1
108010007337 Azurin Proteins 0.000 description 1
241000304886 Bacilli Species 0.000 description 1
108090000145 Bacillolysin Proteins 0.000 description 1
241000193749 Bacillus coagulans Species 0.000 description 1
108010045681 Bacillus stearothermophilus neutral protease Proteins 0.000 description 1
241000193388 Bacillus thuringiensis Species 0.000 description 1
229920002749 Bacterial cellulose Polymers 0.000 description 1
241000692822 Bacteroidales Species 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
102100026189 Beta-galactosidase Human genes 0.000 description 1
101710130006 Beta-glucanase Proteins 0.000 description 1
241001465180 Botrytis Species 0.000 description 1
241000123650 Botrytis cinerea Species 0.000 description 1
241000272074 Bungarus Species 0.000 description 1
241000282832 Camelidae Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
108010006303 Carboxypeptidases Proteins 0.000 description 1
102000005367 Carboxypeptidases Human genes 0.000 description 1
108010053835 Catalase Proteins 0.000 description 1
102100035882 Catalase Human genes 0.000 description 1
102000030523 Catechol oxidase Human genes 0.000 description 1
108010031396 Catechol oxidase Proteins 0.000 description 1
241000282994 Cervidae Species 0.000 description 1
241000221955 Chaetomium Species 0.000 description 1
241001248634 Chaetomium thermophilum Species 0.000 description 1
241001657057 Chaetomium thermophilum var. coprophilum Species 0.000 description 1
241001432959 Chernes Species 0.000 description 1
108010022172 Chitinases Proteins 0.000 description 1
102000012286 Chitinases Human genes 0.000 description 1
108020004638 Circular DNA Proteins 0.000 description 1
241001112696 Clostridia Species 0.000 description 1
241000144948 Colossoma macropomum Species 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
241000238424 Crustacea Species 0.000 description 1
241000235646 Cyberlindnera jadinii Species 0.000 description 1
108010025880 Cyclomaltodextrin glucanotransferase Proteins 0.000 description 1
244000285774 Cyperus esculentus Species 0.000 description 1
235000005853 Cyperus esculentus Nutrition 0.000 description 1
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
108010053770 Deoxyribonucleases Proteins 0.000 description 1
102000016911 Deoxyribonucleases Human genes 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
241000723298 Dicentrarchus labrax Species 0.000 description 1
241001187099 Dickeya Species 0.000 description 1
241000219764 Dolichos Species 0.000 description 1
101710147028 Endo-beta-1,4-galactanase Proteins 0.000 description 1
241000194033 Enterococcus Species 0.000 description 1
241000321429 Epinephelus itajara Species 0.000 description 1
241000206602 Eukaryota Species 0.000 description 1
241000605898 Fibrobacter Species 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
241000605909 Fusobacterium Species 0.000 description 1
241000276438 Gadus morhua Species 0.000 description 1
108010093031 Galactosidases Proteins 0.000 description 1
102000002464 Galactosidases Human genes 0.000 description 1
206010064571 Gene mutation Diseases 0.000 description 1
101100001650 Geobacillus stearothermophilus amyM gene Proteins 0.000 description 1
108050008938 Glucoamylases Proteins 0.000 description 1
241000589236 Gluconobacter Species 0.000 description 1
108010060309 Glucuronidase Proteins 0.000 description 1
102000053187 Glucuronidase Human genes 0.000 description 1
IKAIKUBBJHFNBZ-LURJTMIESA-N Gly-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)CN IKAIKUBBJHFNBZ-LURJTMIESA-N 0.000 description 1
VBOBNHSVQKKTOT-YUMQZZPRSA-N Gly-Lys-Ala Chemical compound [H]NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O VBOBNHSVQKKTOT-YUMQZZPRSA-N 0.000 description 1
241000190687 Gobius Species 0.000 description 1
241000222684 Grifola Species 0.000 description 1
101000882901 Homo sapiens Claudin-2 Proteins 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
235000003332 Ilex aquifolium Nutrition 0.000 description 1
241000209027 Ilex aquifolium Species 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
241000411968 Ilyobacter Species 0.000 description 1
244000017020 Ipomoea batatas Species 0.000 description 1
235000002678 Ipomoea batatas Nutrition 0.000 description 1
102000004195 Isomerases Human genes 0.000 description 1
108090000769 Isomerases Proteins 0.000 description 1
241000824268 Kuma Species 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
125000000769 L-threonyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])[C@](O[H])(C([H])([H])[H])[H] 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
125000003798 L-tyrosyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 description 1
125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 description 1
STECJAGHUSJQJN-USLFZFAMSA-N LSM-4015 Chemical compound C1([C@@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-USLFZFAMSA-N 0.000 description 1
108010059881 Lactase Proteins 0.000 description 1
241000186660 Lactobacillus Species 0.000 description 1
241000194036 Lactococcus Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241000282838 Lama Species 0.000 description 1
241001124553 Lepismatidae Species 0.000 description 1
108010036940 Levansucrase Proteins 0.000 description 1
229920002097 Lichenin Polymers 0.000 description 1
102000003960 Ligases Human genes 0.000 description 1
108090000364 Ligases Proteins 0.000 description 1
108010013563 Lipoprotein Lipase Proteins 0.000 description 1
102000004317 Lyases Human genes 0.000 description 1
108090000856 Lyases Proteins 0.000 description 1
108020002496 Lysophospholipase Proteins 0.000 description 1
241000289619 Macropodidae Species 0.000 description 1
241001417902 Mallotus villosus Species 0.000 description 1
102100024295 Maltase-glucoamylase Human genes 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
229920000057 Mannan Polymers 0.000 description 1
241000123318 Meripilus giganteus Species 0.000 description 1
241000192017 Micrococcaceae Species 0.000 description 1
241001655327 Micrococcales Species 0.000 description 1
241000192041 Micrococcus Species 0.000 description 1
244000235756 Microcos paniculata Species 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
241001502129 Mullus Species 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
241000868066 Myadestes myadestinus Species 0.000 description 1
241000226677 Myceliophthora Species 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
238000005481 NMR spectroscopy Methods 0.000 description 1
241000244206 Nematoda Species 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
244000061176 Nicotiana tabacum Species 0.000 description 1
235000002637 Nicotiana tabacum Nutrition 0.000 description 1
108091028043 Nucleic acid sequence Proteins 0.000 description 1
108700026244 Open Reading Frames Proteins 0.000 description 1
241000611786 Paenibacillus glucanolyticus Species 0.000 description 1
241000193397 Paenibacillus pabuli Species 0.000 description 1
241000740708 Paludibacter Species 0.000 description 1
206010034133 Pathogen resistance Diseases 0.000 description 1
241001494479 Pecora Species 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
241001496963 Penicillium brasilianum Species 0.000 description 1
241000228168 Penicillium sp. Species 0.000 description 1
108700020962 Peroxidase Proteins 0.000 description 1
241000286209 Phasianidae Species 0.000 description 1
102100037883 Phospholipase B1, membrane-associated Human genes 0.000 description 1
108090000553 Phospholipase D Proteins 0.000 description 1
102000011420 Phospholipase D Human genes 0.000 description 1
108010058864 Phospholipases A2 Proteins 0.000 description 1
240000004713 Pisum sativum Species 0.000 description 1
235000010582 Pisum sativum Nutrition 0.000 description 1
241000269908 Platichthys flesus Species 0.000 description 1
241001600434 Plectroglyphidodon lacrymatus Species 0.000 description 1
241000222350 Pleurotus Species 0.000 description 1
108010059820 Polygalacturonase Proteins 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
241001274189 Pomatomus saltatrix Species 0.000 description 1
241000205156 Pyrococcus furiosus Species 0.000 description 1
241001417518 Rachycentridae Species 0.000 description 1
241000157468 Reinhardtius hippoglossoides Species 0.000 description 1
241000235402 Rhizomucor Species 0.000 description 1
102000006382 Ribonucleases Human genes 0.000 description 1
108010083644 Ribonucleases Proteins 0.000 description 1
241000235088 Saccharomyces sp. Species 0.000 description 1
241000192263 Scheffersomyces shehatae Species 0.000 description 1
241000555745 Sciuridae Species 0.000 description 1
241001481818 Sebastes Species 0.000 description 1
241001274979 Selenotoca multifasciata Species 0.000 description 1
241001417495 Serranidae Species 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
244000061456 Solanum tuberosum Species 0.000 description 1
235000002595 Solanum tuberosum Nutrition 0.000 description 1
241001123667 Sordaria fimicola Species 0.000 description 1
241000191940 Staphylococcus Species 0.000 description 1
108091081024 Start codon Proteins 0.000 description 1
101100309436 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) ftf gene Proteins 0.000 description 1
241000187440 Streptomyces cyaneus Species 0.000 description 1
108090000787 Subtilisin Proteins 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
241001484137 Talaromyces leycettanus Species 0.000 description 1
101100157012 Thermoanaerobacterium saccharolyticum (strain DSM 8691 / JW/SL-YS485) xynB gene Proteins 0.000 description 1
241000228178 Thermoascus Species 0.000 description 1
241001313536 Thermothelomyces thermophila Species 0.000 description 1
235000009430 Thespesia populnea Nutrition 0.000 description 1
241000656145 Thyrsites atun Species 0.000 description 1
241000276707 Tilapia Species 0.000 description 1
102000004357 Transferases Human genes 0.000 description 1
108090000992 Transferases Proteins 0.000 description 1
108060008539 Transglutaminase Proteins 0.000 description 1
WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
241000700605 Viruses Species 0.000 description 1
IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 description 1
229920002000 Xyloglucan Polymers 0.000 description 1
241000222124 [Candida] boidinii Species 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000009471 action Effects 0.000 description 1
238000001042 affinity chromatography Methods 0.000 description 1
238000013019 agitation Methods 0.000 description 1
238000012867 alanine scanning Methods 0.000 description 1
WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 description 1
108010028144 alpha-Glucosidases Proteins 0.000 description 1
102000019199 alpha-Mannosidase Human genes 0.000 description 1
108010012864 alpha-Mannosidase Proteins 0.000 description 1
235000012211 aluminium silicate Nutrition 0.000 description 1
238000012870 ammonium sulfate precipitation Methods 0.000 description 1
229960000723 ampicillin Drugs 0.000 description 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
238000013459 approach Methods 0.000 description 1
101150009206 aprE gene Proteins 0.000 description 1
150000001484 arginines Chemical group 0.000 description 1
210000004507 artificial chromosome Anatomy 0.000 description 1
238000013528 artificial neural network Methods 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
229940054340 bacillus coagulans Drugs 0.000 description 1
229940097012 bacillus thuringiensis Drugs 0.000 description 1
239000005016 bacterial cellulose Substances 0.000 description 1
230000003385 bacteriostatic effect Effects 0.000 description 1
235000015278 beef Nutrition 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
108010019077 beta-Amylase Proteins 0.000 description 1
125000000188 beta-D-glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
239000011648 beta-carotene Substances 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
239000003139 biocide Substances 0.000 description 1
239000003225 biodiesel Substances 0.000 description 1
230000009141 biological interaction Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
235000010216 calcium carbonate Nutrition 0.000 description 1
235000019577 caloric intake Nutrition 0.000 description 1
108010089934 carbohydrase Proteins 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
230000008859 change Effects 0.000 description 1
229960005091 chloramphenicol Drugs 0.000 description 1
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
229910000423 chromium oxide Inorganic materials 0.000 description 1
238000004590 computer program Methods 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
108010005400 cutinase Proteins 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
239000005547 deoxyribonucleotide Substances 0.000 description 1
125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
235000013325 dietary fiber Nutrition 0.000 description 1
238000002050 diffraction method Methods 0.000 description 1
238000010410 dusting Methods 0.000 description 1
238000002003 electron diffraction Methods 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
YERABYSOHUZTPQ-UHFFFAOYSA-P endo-1,4-beta-Xylanase Chemical compound C=1C=CC=CC=1C[N+](CC)(CC)CCCNC(C(C=1)=O)=CC(=O)C=1NCCC[N+](CC)(CC)CC1=CC=CC=C1 YERABYSOHUZTPQ-UHFFFAOYSA-P 0.000 description 1
108010091371 endoglucanase 1 Proteins 0.000 description 1
108010091384 endoglucanase 2 Proteins 0.000 description 1
230000007071 enzymatic hydrolysis Effects 0.000 description 1
238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
FPIQZBQZKBKLEI-UHFFFAOYSA-N ethyl 1-[[2-chloroethyl(nitroso)carbamoyl]amino]cyclohexane-1-carboxylate Chemical compound ClCCN(N=O)C(=O)NC1(C(=O)OCC)CCCCC1 FPIQZBQZKBKLEI-UHFFFAOYSA-N 0.000 description 1
210000003527 eukaryotic cell Anatomy 0.000 description 1
230000029142 excretion Effects 0.000 description 1
108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 1
108010093305 exopolygalacturonase Proteins 0.000 description 1
235000019620 fat digestibility Nutrition 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
235000021050 feed intake Nutrition 0.000 description 1
235000021001 fermented dairy product Nutrition 0.000 description 1
229940114123 ferulate Drugs 0.000 description 1
KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
108010041969 feruloyl esterase Proteins 0.000 description 1
235000013373 food additive Nutrition 0.000 description 1
239000002778 food additive Substances 0.000 description 1
230000037406 food intake Effects 0.000 description 1
239000004459 forage Substances 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
239000000174 gluconic acid Substances 0.000 description 1
235000012208 gluconic acid Nutrition 0.000 description 1
235000001727 glucose Nutrition 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
150000002333 glycines Chemical class 0.000 description 1
230000013595 glycosylation Effects 0.000 description 1
238000006206 glycosylation reaction Methods 0.000 description 1
108010015792 glycyllysine Proteins 0.000 description 1
230000005484 gravity Effects 0.000 description 1
244000005709 gut microbiome Species 0.000 description 1
230000036541 health Effects 0.000 description 1
229910001385 heavy metal Inorganic materials 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
230000036039 immunity Effects 0.000 description 1
239000013067 intermediate product Substances 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
230000007413 intestinal health Effects 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
239000001573 invertase Substances 0.000 description 1
235000011073 invertase Nutrition 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
238000001155 isoelectric focusing Methods 0.000 description 1
229960000318 kanamycin Drugs 0.000 description 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
229930027917 kanamycin Natural products 0.000 description 1
229930182823 kanamycin A Natural products 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
238000002372 labelling Methods 0.000 description 1
229940039696 lactobacillus Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000010985 leather Substances 0.000 description 1
235000021374 legumes Nutrition 0.000 description 1
235000021440 light beer Nutrition 0.000 description 1
229920005610 lignin Polymers 0.000 description 1
230000001533 ligninolytic effect Effects 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
244000144972 livestock Species 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
239000012092 media component Substances 0.000 description 1
238000005374 membrane filtration Methods 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
238000001471 micro-filtration Methods 0.000 description 1
238000009629 microbiological culture Methods 0.000 description 1
238000013048 microbiological method Methods 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
210000001724 microfibril Anatomy 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
101150105920 npr gene Proteins 0.000 description 1
101150017837 nprM gene Proteins 0.000 description 1
230000008520 organization Effects 0.000 description 1
108020004410 pectinesterase Proteins 0.000 description 1
230000002351 pectolytic effect Effects 0.000 description 1
101150019841 penP gene Proteins 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
229940072417 peroxidase Drugs 0.000 description 1
108040007629 peroxidase activity proteins Proteins 0.000 description 1
235000020030 perry Nutrition 0.000 description 1
238000002823 phage display Methods 0.000 description 1
230000026731 phosphorylation Effects 0.000 description 1
238000006366 phosphorylation reaction Methods 0.000 description 1
238000005222 photoaffinity labeling Methods 0.000 description 1
230000008488 polyadenylation Effects 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
235000020004 porter Nutrition 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
230000001124 posttranscriptional effect Effects 0.000 description 1
OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
229910052939 potassium sulfate Inorganic materials 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
235000012015 potatoes Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000002243 precursor Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000003825 pressing Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
210000001236 prokaryotic cell Anatomy 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
229960004063 propylene glycol Drugs 0.000 description 1
238000001742 protein purification Methods 0.000 description 1
101150108007 prs gene Proteins 0.000 description 1
101150086435 prs1 gene Proteins 0.000 description 1
101150070305 prsA gene Proteins 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
238000004064 recycling Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000007670 refining Methods 0.000 description 1
230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
238000010839 reverse transcription Methods 0.000 description 1
239000002151 riboflavin Substances 0.000 description 1
235000019192 riboflavin Nutrition 0.000 description 1
229960002477 riboflavin Drugs 0.000 description 1
108020004418 ribosomal RNA Proteins 0.000 description 1
102220083468 rs148508128 Human genes 0.000 description 1
102220005204 rs63750783 Human genes 0.000 description 1
102220123717 rs759057581 Human genes 0.000 description 1
102220239115 rs779234287 Human genes 0.000 description 1
102220087235 rs864622622 Human genes 0.000 description 1
101150025220 sacB gene Proteins 0.000 description 1
238000012807 shake-flask culturing Methods 0.000 description 1
101150091813 shfl gene Proteins 0.000 description 1
239000004460 silage Substances 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
238000001542 size-exclusion chromatography Methods 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000007974 sodium acetate buffer Substances 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000012064 sodium phosphate buffer Substances 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000010563 solid-state fermentation Methods 0.000 description 1
238000007614 solvation Methods 0.000 description 1
229960000268 spectinomycin Drugs 0.000 description 1
UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000010907 stover Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
150000003588 threonines Chemical group 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
238000010361 transduction Methods 0.000 description 1
230000026683 transduction Effects 0.000 description 1
238000001890 transfection Methods 0.000 description 1
102000003601 transglutaminase Human genes 0.000 description 1
230000032258 transport Effects 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
235000020985 whole grains Nutrition 0.000 description 1
101150110790 xylB gene Proteins 0.000 description 1
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1

Images

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/248—Xylanases
- C12N9/2482—Endo-1,4-beta-xylanase (3.2.1.8)
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
- A23K10/38—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material from distillers' or brewers' waste
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
- C12P7/10—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01008—Endo-1,4-beta-xylanase (3.2.1.8)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Polymers & Plastics (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Food Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Animal Husbandry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Botany (AREA)
Mycology (AREA)
Physiology (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CN202080009202.6A 2019-01-31 2020-01-29 具有木聚糖酶活性的多肽及其用于改善动物饲料营养质量的用途 Pending CN113302294A (zh)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201962799355P	2019-01-31	2019-01-31
US62/799,355		2019-01-31
PCT/US2020/015648 WO2020160126A1 (en)	2019-01-31	2020-01-29	Polypeptides having xylanase activity and use thereof for improving the nutritional quality of animal feed

Publications (1)

Publication Number	Publication Date
CN113302294A true CN113302294A (zh)	2021-08-24

Family

ID=69740653

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN202080009202.6A Pending CN113302294A (zh)	2019-01-31	2020-01-29	具有木聚糖酶活性的多肽及其用于改善动物饲料营养质量的用途

Country Status (4)

Country	Link
EP (1)	EP3918060A1 (de)
CN (1)	CN113302294A (de)
BR (1)	BR112021014873A2 (de)
WO (1)	WO2020160126A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN117716046A (zh) *	2021-06-29	2024-03-15	诺维信公司	用于在发酵中使用纤维降解酶生产发酵产物的工艺
CN113466288B (zh) *	2021-07-09	2023-03-21	贵州茅台酒股份有限公司	一种以峰值糊化温度评价高粱的方法
CN114196550B (zh) *	2021-12-20	2024-04-26	安徽粤智徽源生物科技有限公司	一株金黄篮状菌及利用其光照刺激发酵生产红色素的方法
WO2024137252A1 (en)	2022-12-19	2024-06-27	Novozymes A/S	Process for reducing syrup viscosity in the backend of a process for producing a fermentation product
CN116286751B (zh) *	2023-05-15	2023-07-25	北京市科学技术研究院	催化效率提高的双功能纤维素酶突变体及其应用

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5534046A (en)	1978-09-01	1980-03-10	Cpc International Inc	Novel glucoamyrase having excellent heat resistance and production
US4560651A (en)	1981-04-20	1985-12-24	Novo Industri A/S	Debranching enzyme product, preparation and use thereof
NO840200L (no)	1983-01-28	1984-07-30	Cefus Corp	Glukoamylase cdna.
DK135983D0 (da)	1983-03-25	1983-03-25	Novo Industri As	Maltogen amylaseenzymprodukt og fremgangsmade til dets fremstilling og anvendelse
US4536477A (en)	1983-08-17	1985-08-20	Cpc International Inc.	Thermostable glucoamylase and method for its production
US4587215A (en)	1984-06-25	1986-05-06	Uop Inc.	Highly thermostable amyloglucosidase
US4628031A (en)	1984-09-18	1986-12-09	Michigan Biotechnology Institute	Thermostable starch converting enzymes
JPS62126989A (ja)	1985-11-26	1987-06-09	Godo Shiyusei Kk	コルテイシウム属担子菌の生産する酵素を用いた澱粉質の無蒸煮糖化法
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
CA2058633C (en)	1989-06-13	2000-03-21	Virgil B. Lawlis, Jr.	A method for killing cells without lysis
SK466390A3 (en)	1989-09-27	2000-05-16	Gist Brocades Nv	Purified and isolated dna sequence, construct, vector, transformed cell, peptide or protein having phytase activity, process for its preparation, and its use
US5162210A (en)	1990-06-29	1992-11-10	Iowa State University Research Foundation	Process for enzymatic hydrolysis of starch to glucose
WO1992002614A1 (en)	1990-08-01	1992-02-20	Novo Nordisk A/S	Novel thermostable pullulanases
IL99552A0 (en)	1990-09-28	1992-08-18	Ixsys Inc	Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
FR2704860B1 (fr)	1993-05-05	1995-07-13	Pasteur Institut	Sequences de nucleotides du locus cryiiia pour le controle de l'expression de sequences d'adn dans un hote cellulaire.
JP3484208B2 (ja)	1993-08-30	2004-01-06	天野エンザイム株式会社	新規フィターゼ及びその製造法
DE4343591A1 (de)	1993-12-21	1995-06-22	Evotec Biosystems Gmbh	Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US5605793A (en)	1994-02-17	1997-02-25	Affymax Technologies N.V.	Methods for in vitro recombination
ES2268687T3 (es)	1994-04-25	2007-03-16	Dsm Ip Assets B.V.	Polipeptidos con actividad fitasa.
DE69523052T2 (de)	1994-06-03	2002-06-20	Novo Nordisk Biotech, Inc.	Gereinigte myceliophthora laccasen und nukleinsäuren dafür kodierend
US5830732A (en)	1994-07-05	1998-11-03	Mitsui Toatsu Chemicals, Inc.	Phytase
US6093562A (en)	1996-02-05	2000-07-25	Novo Nordisk A/S	Amylase variants
AR000862A1 (es)	1995-02-03	1997-08-06	Novozymes As	Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del
JP4047379B2 (ja)	1995-02-03	2008-02-13	ノボザイムスアクティーゼルスカブ	予め決められた性質を有するα−アミラーゼ変異体のデザイン方法
KR0169913B1 (ko)	1996-03-14	1999-01-15	김은영	신균주 바실러스속 ds11과 이로부터 생산되는 신규 파이타아제
EA199800891A1 (ru)	1996-04-05	1999-04-29	Киова Хакко Когио Ко., Лтд	Новая фитаза и ген, кодирующий указанную фитазу
CN1246455C (zh)	1996-04-30	2006-03-22	诺沃奇梅兹有限公司	α－淀粉酶变体
US5985605A (en)	1996-06-14	1999-11-16	Her Majesty The Queen In Right Of Canada, As Represented By The Dept. Of Agriculture & Agri-Food Canada	DNA sequences encoding phytases of ruminal microorganisms
FR2751987B1 (fr)	1996-08-01	1998-12-31	Biocem	Phytases de plantes et applications biotechnologiques
GB2316082A (en)	1996-08-13	1998-02-18	Finnfeeds Int Ltd	Phytase
EA003632B1 (ru)	1996-09-25	2003-08-28	Киова Хакко Когио Ко., Лтд.	Фитазы из микроорганизма monascus anka, способ их получения и корм для животных, содержащий указанные фитазы
GB2319030A (en)	1996-11-05	1998-05-13	Finnfeeds Int Ltd	Phytase extracted from soybean
DE69739288D1 (de)	1996-12-20	2009-04-16	Novozymes As	Polypeptide mit phytase-aktivität
WO1998028408A1 (en)	1996-12-20	1998-07-02	Novo Nordisk A/S	Peniophora phytase
CA2231948C (en)	1997-03-25	2010-05-18	F. Hoffmann-La Roche Ag	Modified phytases
KR100206453B1 (ko)	1997-03-27	1999-07-01	박원훈	신규한플라즈미드를이용하여형질전환시킨균주 이.채씨오엘아이.피와이로부터생산된피타제
US6358726B1 (en)	1997-06-10	2002-03-19	Takara Shuzo Co., Ltd.	Thermostable protease
NZ330940A (en)	1997-07-24	2000-02-28	F	Production of consensus phytases from fungal origin using computer programmes
EP1023439B1 (de)	1997-10-13	2009-02-18	Novozymes A/S	MUTANTEN DER alpha-AMYLASE
WO1999028448A1 (en)	1997-11-26	1999-06-10	Novo Nordisk A/S	Thermostable glucoamylase
US5955310A (en)	1998-02-26	1999-09-21	Novo Nordisk Biotech, Inc.	Methods for producing a polypeptide in a bacillus cell
EP1058724B1 (de)	1998-02-27	2010-12-01	Novozymes A/S	Maltogene alpha-amylase varianten
WO1999048330A1 (en)	1998-03-19	1999-09-23	Koninklijke Philips Electronics N.V.	A hearing aid comprising a detector for wireless reception of signals and a system comprising said hearing aid
CN1309699A (zh)	1998-03-23	2001-08-22	诺维信公司	植酸酶变体
MXPA01000352A (es)	1998-07-15	2002-06-04	Novozymes As	Varientes de glucoamilasa.
BRPI0009362B8 (pt)	1999-03-30	2019-08-20	Novozymes As	variante de uma alfa-amilase precursora, e, uso de uma variante de alfa-amilase
EP2009098A1 (de)	1999-07-09	2008-12-31	Novozymes A/S	Variante der Glucoamylase
WO2001051620A2 (en)	2000-01-12	2001-07-19	Novozymes A/S	Pullulanase variants and methods for preparing such variants with predetermined properties
EP2180035A1 (de)	2000-08-01	2010-04-28	Novozymes A/S	Alpha-Amylase-Mutanten mit veränderten Eigenschaften
US20020155574A1 (en)	2000-08-01	2002-10-24	Novozymes A/S	Alpha-amylase mutants with altered properties
EP1395653A2 (de)	2001-05-18	2004-03-10	Novozymes A/S	Polypeptide mit cellobiaseaktivität und diese codierende polypeptide
ES2337131T3 (es)	2001-12-07	2010-04-21	Novozymes A/S	Polipeptidos con actividad proteasa y acidos nucleicos que codifican los mismos.
CN101177675B (zh)	2002-02-08	2014-05-21	诺维信公司	肌醇六磷酸酶变体
US7442398B2 (en)	2003-03-25	2008-10-28	Republic Of National Fisheries Research And Development Institute	Phytase produced from Citrobacter braakii
CN1875097B (zh)	2003-10-28	2013-04-24	诺维信北美公司	杂交酶
ES2437198T3 (es)	2003-10-28	2014-01-09	Novozymes Inc.	Polipéptidos con actividad de beta-glucosidasa y polinucleótidos aislados que codifican los polipéptidos
WO2005074647A2 (en)	2004-01-30	2005-08-18	Novozymes Inc.	Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
DK1733033T3 (da)	2004-02-06	2012-09-24	Novozymes Inc	Polypeptider med cellulolytisk forbedrende aktivitet og polynukleotider, der koder for disse
AR050895A1 (es)	2004-10-04	2006-11-29	Novozymes As	Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican
JP5221137B2 (ja)	2004-10-04	2013-06-26	ノボザイムスアクティーゼルスカブ	フィターゼ活性を有するポリペプチド及びそれをコードするポリヌクレオチド
GB0422052D0 (en)	2004-10-04	2004-11-03	Dansico As	Enzymes
WO2006063588A1 (en)	2004-12-13	2006-06-22	Novozymes A/S	Polypeptides having acid phosphatase activity and polynucleotides encoding same
AU2005319074B2 (en)	2004-12-22	2011-03-24	Novozymes A/S	Enzymes for starch processing
WO2007019442A2 (en)	2005-08-04	2007-02-15	Novozymes, Inc.	Polypeptides having beta-glucosidase activity and polynucleotides encoding same
EP2001999B1 (de)	2006-04-04	2012-05-16	Novozymes A/S	Phytasevarianten
CA2645006A1 (en)	2006-04-19	2007-11-01	Novozymes North America, Inc.	Polypeptides having glucoamylase activity and polynucleotides encoding same
US20090142818A1 (en)	2006-05-12	2009-06-04	Novozymes A/S	Process of producing a fermentation product
WO2008057637A2 (en)	2006-07-21	2008-05-15	Novozymes, Inc.	Methods of increasing secretion of polypeptides having biological activity
WO2008092901A2 (en)	2007-01-30	2008-08-07	Novozymes A/S	Polypeptides having phytase activty and polynucleotides encoding same
EP2129781B1 (de)	2007-03-26	2014-01-22	Novozymes A/S	Hafnia-phytase
DK2215202T3 (da)	2007-11-05	2017-11-27	Danisco Us Inc	VARIANTER AF BACILLUS sp. TS-23 ALPHA-AMYLASE MED ÆNDREDE EGENSKABER
US8673609B2 (en)	2008-04-18	2014-03-18	Danisco Us Inc.	Buttiauxella sp. phytase variants
CA2726688A1 (en)	2008-06-23	2010-01-21	Novozymes A/S	Processes for producing fermentation products
EP2342323B1 (de)	2008-09-26	2013-06-05	Novozymes A/S	Hafnia-phytasevarianten
CN102224245B (zh)	2008-09-30	2016-01-13	诺维信股份有限公司	在丝状真菌细胞中使用阳性和阴性选择性基因的方法
RU2560424C2 (ru)	2009-02-20	2015-08-20	ДАНИСКО ЮЭс ИНК.	Способ получения состава ферментационного бульона
WO2010138754A1 (en)	2009-05-29	2010-12-02	Novozymes, Inc.	Methods for enhancing the degradation or conversion of cellulosic material
US8148103B2 (en)	2009-09-29	2012-04-03	Novozymes, Inc.	Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
DK2496694T3 (en)	2009-11-06	2017-06-06	Novozymes Inc	COMPOSITIONS FOR SACCHARIFYING CELLULOS MATERIAL
MX2012006096A (es)	2009-11-30	2012-07-03	Novozymes North America Inc	Polipeptidos que tienen actividad glucoamilasa y polinucleotidos que codifican para los mismos.
CA2782036C (en)	2009-12-01	2019-01-15	Novozymes A/S	Polypeptides having glucoamylase activity and polynucleotides encoding same
EP2515931A4 (de)	2009-12-22	2013-05-22	Novozymes As	Zusammensetzungen mit einem verstärkungspolypeptid und einem stärkeabbauenden enzym sowie verwendungen davon
DK2558484T3 (en)	2010-04-14	2016-03-29	Novozymes As	Polypeptides having glucoamylase activity and polynucleotides encoding them
BR112013004256A2 (pt)	2010-10-01	2016-08-02	Novozymes Inc	variante de beta-glicosidase,polinucleotídeo isolado, célula hospedeira recombinante, métodos para produzir uma variante, para degradar um material celulósico, para produzir um produto de fermentação, e para fermentar um material celulósico, e, formulação de caldo total ou composição de cultura de células.
DK2638154T3 (da)	2010-11-08	2017-01-02	Novozymes As	Polypeptider med glucoamylaseaktivitet og polynukleotider, der koder for dem
CA2842248C (en)	2011-09-06	2021-02-16	Novozymes A/S	Glucoamylase variants and polynucleotides encoding same
EA201490649A1 (ru)	2011-10-11	2014-07-30	Новозимс А/С	Варианты глюкоамилазы и кодирующие их полинуклеотиды
US9856498B2 (en)	2012-03-30	2018-01-02	Novozymes A/S	Processes of producing fermentation products
WO2017050291A1 (en) *	2015-09-25	2017-03-30	Novozymes A/S	Use of serine proteases for improving ethanol yield
CA3006992A1 (en)	2015-12-22	2017-06-29	Novozymes A/S	Processes for improving fermentation product yield using phospholipase c
WO2017148389A1 (en) *	2016-03-01	2017-09-08	Novozymes A/S	Combined use of at least one endo-protease and at least one exo-protease in an ssf process for improving ethanol yield
IL247569A0 (en) *	2016-08-30	2016-11-30	Yeda Res & Dev	An enzymatic complex for the breakdown of lignocellulosic material

2020
- 2020-01-29 WO PCT/US2020/015648 patent/WO2020160126A1/en unknown
- 2020-01-29 CN CN202080009202.6A patent/CN113302294A/zh active Pending
- 2020-01-29 BR BR112021014873-6A patent/BR112021014873A2/pt not_active Application Discontinuation
- 2020-01-29 EP EP20708857.6A patent/EP3918060A1/de not_active Withdrawn

Also Published As

Publication number	Publication date
WO2020160126A1 (en)	2020-08-06
EP3918060A1 (de)	2021-12-08
BR112021014873A2 (pt)	2021-10-05

Legal Events

Date	Code	Title	Description
2021-08-24	PB01	Publication
2021-08-24	PB01	Publication
2022-07-15	WD01	Invention patent application deemed withdrawn after publication
2022-07-15	WD01	Invention patent application deemed withdrawn after publication	Application publication date: 20210824

Publication	Publication Date	Title
US11685910B2 (en)	2023-06-27	Polypeptides having trehalase activity and the use thereof in process of producing fermentation products
EP2358878B1 (de)	2014-10-15	Polypeptide mit amylolytischer verstärkungsaktivität und dafür codierende polynukloeotide
US11795481B2 (en)	2023-10-24	Processes for producing a fermentation product
US20220279818A1 (en)	2022-09-08	Enzyme blends and processes for producing a high protein feed ingredient from a whole stillage byproduct
CN105339494B (zh)	2020-04-17	普鲁兰酶嵌合体以及编码它们的多核苷酸
CN105960457B (zh)	2021-09-03	普鲁兰酶变体以及编码它们的多核苷酸
CN113302294A (zh)	2021-08-24	具有木聚糖酶活性的多肽及其用于改善动物饲料营养质量的用途
US20210198618A1 (en)	2021-07-01	Processes for enhancing yeast growth and productivity
US20200263207A1 (en)	2020-08-20	Enzyme blends and processes for improving the nutritional quality of animal feed
AU2019231645B2 (en)	2023-05-11	Glucoamylases and methods of use thereof
US20210269833A1 (en)	2021-09-02	Processes for producing fermentation products
US20230399632A1 (en)	2023-12-14	Glucoamylase Variants and Polynucleotides Encoding Same
CN111094562A (zh)	2020-05-01	具有海藻糖酶活性的多肽及其在产生发酵产物的方法中的用途