CN113288924A - 一种增强免疫力的中药组合物及制剂 - Google Patents
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Abstract
本发明涉及食品、保健食品、中药领域,尤其是指一种具有增强免疫力的中药组合物及制剂。由以下重量份数的原料制备而成:菊苣30‑80份,川牛膝20‑70份。菊苣和川牛膝二药合用,菊苣健胃消食,利尿消肿;川牛膝利水通淋,兼能补益肝肾。共奏疏肝和胃、利湿泻浊之功。没有配伍禁忌,药性平和。扶正固本,利湿祛邪,标本兼顾,相得益彰。同时菊苣多糖、川牛膝多糖,多种活性多糖优势互补、协同作用,能有效发挥增强免疫力的保健功能。
Description
技术领域
本发明涉及一种食品、保健食品、中药领域,尤其是指一种具有增强免疫力的中药组合物及制剂。
技术背景:
所谓“免疫”就是免患疾病的意思。人的机体本身具有排除异物、保卫自己的免疫***,即是机体内在抗病能力,中医称之为“正气”早在两千多年前《内经》就指出:“真气从之,精神内守,病安从来”。这里所说的“真气”就是机体抵抗病邪的、“正气”,只要体内正气旺盛,纵有许多致病因素(邪气),正气也能抵御(驱出或消灭之),机体就可免于生病。
中医非常强调“正气”在发病学上的主导作用。《内经》说:“正气存内,邪不可干”、“邪之所凑,其气必虚”。认为疾病的发生、发展和转归,取决于正邪斗争的消长,从而提出了“扶正祛邪”的基本治疗法则。实践证明,这种从整体出发,强调正气与疾病斗争的指导思想对防治疾病具有重要的指导意义。
中医学对疾病的预防和早期治疗是十分重视的,在预防和治疗疾病中,所用的方法也是极其丰富的。而运用现代“免疫学”概念来防治疾病的事例更是屡见不鲜。如早在晋朝葛洪《时后方》中,就记载:“疗制犬咬人方:乃杀所咬犬,取胆敷之,后不复发”。意思是说:被疯狗咬伤后,要防治狂犬病,可以取用该疯狗的胆汁,外敷于伤口,这个例子说明古人很早就在免疫学的思想。在我国宋朝时期,民间就使用天花病人的病痂吹入健康儿童鼻内来预防天花的方法。到十八世纪左右。即有《免疫类方》一书出现,所以“免疫”一词最早源出于我国。
中医学不但对增强机体免疫能力有行之有效的理论和方法,而且对迄今尚无有效治疗办法的免疫性疾病,也积累了丰富的经验。用现代免疫学理论和技术,研究中草药对增强与调节机体免疫功能的作用,这对阐明有关中医理论的物质基础,指导中西医结合,防治常见病、多发病,特别对攻克恶性肿瘤有着十分重要的意义。
中药免疫学研究发现,中药既可以增强机体细胞免疫及体液免疫功能,又可促进淋巴细胞、单核巨噬细胞以及造血干细胞的生理功能。
菊苣(Cichorium intybus L.)又名苦苣、法国苦苣、奇可力、咖啡草等,是菊科菊苣属多年宿根植物,原产于地中海、中亚和北非,早在古罗马和希腊时代己有栽培。菊苣在欧洲栽培甚多,多年来常被用作叶类蔬菜、牧草、制糖原料及咖啡的替代品。我国新疆、山东、内蒙古等地也有分布。菊苣是维吾尔族和蒙古族***滑肌张力。种子有非特异性植物血球凝集素”。国外亦有菊苣药用的研究报道。研究表明,菊苣提取物不仅是菊粉、菊苣酸、果糖等的重要来源,菊苣提取物的成分复杂,目前从菊苣中已分离得到多糖类、萜类(尤其是倍半萜类)、黄酮类、酚酸类化合物和多种维生素、金属元素等化学成分。而且它本身也具有许多的生理活性,比如增强免疫能力、抗炎作用、降尿酸、降低胆固醇和血糖等。
川牛膝为苋科植物川牛膝Cy athula officinalis Kuan的干燥根。性平,味甘、微苦。归肝、肾经。具有祛风,利湿,通经,活血之功效。用于经闭症瘕,胞衣不下,关节痹痛,足痿筋挛,尿血血淋,跌扑损伤等。研究发现川牛膝中含有多种药用成分,如多糖、皂苷类、甾酮类、多糖类、甜菜碱以及多种微量的元素。其化学成分主要是生物碱与甾体酮,现代药理研究表明具有改善微循环、抗炎、抗生育、延缓衰老、抗肿瘤、调节免疫等方面的作用。
发明内容
本发明的目的是提供一种增强免疫力的中药组合物及制剂
本发明是通过下列技术方案实现的:一种增强免疫力的中药组合物,由以下重量份数的原料制备而成:菊苣30-80份,川牛膝20-70份。
进一步地,由如下重量份数的原料制备而成:菊苣45-70份,川牛膝30-55份。
进一步地,由如下重量份数的原料制备而成:菊苣63份,川牛膝37份。
一种增强免疫力的中药制剂,上述的增强免疫力的中药组合物和辅料组成,制成颗粒剂、粉剂、胶囊、片剂、丸剂或液体制剂。
进一步地,将菊苣、川牛膝分别水提,水提液浓缩成稠膏,喷雾干燥获得膏粉后,加入辅料,粉碎、过筛、混合后制成颗粒剂、粉剂、胶囊、片剂、丸剂、液体等剂型
进一步地,所述辅料为填充剂、矫味剂、润滑剂、崩解剂中的一种或多种。本发明的优点:
多糖类化合物广泛存在于动物、植物和微生物中,是生命物质中重要的成份。植物多糖可以通过增大巨噬细胞体积来提高机体免疫力。植物多糖对巨噬细胞吞噬活性的影响与其浓度有一定关系,在适当的浓度范围内能促进巨噬细胞的吞噬作用。植物多糖可以通过调节巨噬细胞细胞因子的分泌量来调节巨噬细胞功能。植物多糖可以通过调节巨噬细胞内酶的活性进而影响巨噬细胞的功能。植物多糖对淋巴细胞的调节作用主要体现在对其增殖能力、亚群结构、细胞因子分泌等的影响。一定浓度的植物多糖可以促进淋巴细胞增殖,改善淋巴细胞亚群结构,从而调节机体免疫功能。植物多糖可以通过促进细胞因子分泌来增强机体的免疫功能。植物多糖可以提高动物机体血清中抗体水平,增强机体免疫功能。
菊苣根富含多糖、生物碱、萜类等多种生物活性物质,而菊苣多糖在降血糖、降血脂、抗氧化、保肝、延缓衰老、提高机体免疫力等方面都表现出了较好的生物活性。陈立阁等更是发现奇可力多糖(菊苣多糖)具有抗肿瘤作用,主要体现在菊苣多糖能明显抑制S180荷瘤小鼠肿瘤的生长,延长S180荷瘤小鼠的生存时间,另对肝癌、胃癌细胞生长亦具有一定抑制作用。菊苣多糖的开发与应用也已成为食品、医药、生物工程等领域的重要研究方向。
川牛膝在祖国医学中,被用于治疗多种疑难杂症,而且现代医学临床也证实牛膝对很多疾病有确切疗效。牛膝含有多种次生代谢产物,如齐墩果酸及其皂甙、蒽醌类化合物、黄酮类化合物、生物碱、蜕皮素等,它们都具有生理活性。牛膝还含有较高比例的可溶性多糖。牛膝多糖有显著的抗癌、抗放射、抗肝炎、抗衰老等功效,而且具有双向免疫调节作用。牛膝多糖又有分子量小,水溶性好,毒性低的优点,不但可以口服,还可以注射,是一种很有前景的治疗用多糖药物。
菊苣和川牛膝二药合用,菊苣健胃消食,利尿消肿;川牛膝利水通淋,兼能补益肝肾。共奏疏肝和胃、利湿泻浊之功。没有配伍禁忌,药性平和。扶正固本,利湿祛邪,标本兼顾,相得益彰。同时菊苣多糖、牛膝多糖,多种活性多糖优势互补、协同作用,能有效发挥增强免疫力的保健功能。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面本发明中的技术方案进行清楚、完整地描述,显然,所描述的实施例是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
增强免疫力的中药组合物,由如下重量份数的原料制备而成:菊苣60份,川牛膝40份,每份5kg。
实施例2:
增强免疫力的中药组合物,由如下重量份数的原料制备而成:菊苣65份,川牛膝35份;
实施例3:
增强免疫力的中药组合物,由如下重量份数的原料制备而成:菊苣55份,川牛膝45份;
实施例4:
增强免疫力的中药组合物,由如下重量份数的原料制备而成:菊苣50份,川牛膝50份。
实施例5:
增强免疫力的中药制剂,将实施例1-4的中药组合物各组分分别水提,水提液浓缩成稠膏,喷雾干燥获得膏粉后,分别粉碎、过筛60-100目得到提取物粉再混合40-60分钟得到混合物粉,根据所需剂型加入填充剂、矫味剂、润滑剂、崩解剂中的一种或多种,粉碎、过筛、混合后制成颗粒剂、粉剂、胶囊、片剂、丸剂、液体剂型。
实施例6
增强免疫力的中药制剂,将实施例1-4的中药组合物中药材混合水提,水提液浓缩成稠膏,喷雾干燥获得膏粉后,粉碎、过筛60-100目得到混合物粉,根据所需剂型加入填充剂、矫味剂、润滑剂、崩解剂中的一种或多种,混合后按常规制剂工艺制成颗粒剂、粉剂、胶囊、片剂、丸剂、液体剂型。
效果例:
病例1.李某,男,47岁,血常规检测为白细胞计数3.32×109/L,中性粒细胞计数为1.82×109/L。口服实施例4菊苣牛膝制成的粉剂(一包内含菊苣6g,川牛膝3g提取的组合物)每日2次,每次一包,未接受其他药物治疗。10天后血常规检测为白细胞计数6.63×109/L,中性粒细胞计数为3.77×109/L。均在合格范围内,后续跟踪情况稳定。
以上所述实施例仅举例表达本发明的具体实施方式,其描述较具体详细,但并不能因此而理解为对本发明专利应用范围的限制;应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (6)
1.一种增强免疫力的中药组合物,其特征在于:由以下重量份数的原料制备而成:菊苣30-80份,川牛膝20-70份。
2.根据权利要求1所述的增强免疫力的中药组合物,其特征在于:由如下重量份数的原料制备而成:菊苣45-70份,川牛膝30-55份。
3.根据权利要求2所述的增强免疫力的中药组合物,其特征在于:由如下重量份数的原料制备而成:菊苣63份,川牛膝37份。
4.一种增强免疫力的中药制剂,其特征在于:由权利要求1-3任一所述的增强免疫力的中药组合物和辅料组成,制成颗粒剂、粉剂、胶囊、片剂、丸剂或液体制剂。
5.根据权利要求4所述的增强免疫力的制剂,其特征在于:将菊苣、川牛膝分别水提,水提液浓缩成稠膏,喷雾干燥获得膏粉后,加入辅料,粉碎、过筛、混合后制成颗粒剂、粉剂、胶囊、片剂、丸剂、液体剂型。
6.根据权利要求5所述的增强免疫力的中药制剂,其特征在于:所述辅料为填充剂、矫味剂、润滑剂、崩解剂中的一种或多种。
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