CN113230421A - Medical solid coupling patch and preparation method thereof - Google Patents
Medical solid coupling patch and preparation method thereof Download PDFInfo
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- CN113230421A CN113230421A CN202110468938.6A CN202110468938A CN113230421A CN 113230421 A CN113230421 A CN 113230421A CN 202110468938 A CN202110468938 A CN 202110468938A CN 113230421 A CN113230421 A CN 113230421A
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- 230000008878 coupling Effects 0.000 title claims abstract description 45
- 238000010168 coupling process Methods 0.000 title claims abstract description 45
- 238000005859 coupling reaction Methods 0.000 title claims abstract description 45
- 239000007787 solid Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000011159 matrix material Substances 0.000 claims abstract description 21
- 239000003755 preservative agent Substances 0.000 claims abstract description 20
- 230000002335 preservative effect Effects 0.000 claims abstract description 20
- 239000003906 humectant Substances 0.000 claims abstract description 17
- 239000008213 purified water Substances 0.000 claims abstract description 15
- 108010010803 Gelatin Proteins 0.000 claims abstract description 12
- 229920000161 Locust bean gum Polymers 0.000 claims abstract description 12
- 239000000679 carrageenan Substances 0.000 claims abstract description 12
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 12
- 229940113118 carrageenan Drugs 0.000 claims abstract description 12
- 229920001525 carrageenan Polymers 0.000 claims abstract description 12
- 239000008273 gelatin Substances 0.000 claims abstract description 12
- 229920000159 gelatin Polymers 0.000 claims abstract description 12
- 235000019322 gelatine Nutrition 0.000 claims abstract description 12
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 12
- 239000000711 locust bean gum Substances 0.000 claims abstract description 12
- 235000010420 locust bean gum Nutrition 0.000 claims abstract description 12
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 12
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims abstract description 6
- 244000247812 Amorphophallus rivieri Species 0.000 claims abstract description 6
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims abstract description 6
- 229920002581 Glucomannan Polymers 0.000 claims abstract description 6
- 229920002752 Konjac Polymers 0.000 claims abstract description 6
- 229940046240 glucomannan Drugs 0.000 claims abstract description 6
- 239000000252 konjac Substances 0.000 claims abstract description 6
- 235000010485 konjac Nutrition 0.000 claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 31
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 26
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 12
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 11
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 11
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 11
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Substances [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims description 11
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- 239000006185 dispersion Substances 0.000 claims description 8
- 229910001923 silver oxide Inorganic materials 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 238000010008 shearing Methods 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 16
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 2
- 239000000523 sample Substances 0.000 description 7
- 239000007822 coupling agent Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
- A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
A medical solid coupling patch and a preparation method thereof relate to the technical field of ultrasonic detection supplies and comprise a matrix material, a humectant, nano silver ionized water, purified water and a preservative, wherein the matrix material is one or more of carrageenan, konjac glucomannan, locust bean gum and gelatin, the mass percent of the matrix material is 2-10%, the mass percent of the humectant is 5-10%, the mass percent of the nano silver ionized water is 5-10%, the mass percent of the purified water is 70-87%, and the balance is the preservative; when in use, the comfort of the patient is higher, and the detection operation of the doctor is relatively simple and more efficient. The preparation method of the medical solid coupling patch is simple and easy to operate, and is easy for large-scale production.
Description
The technical field is as follows:
the invention relates to the technical field of ultrasonic detection articles, in particular to a medical solid coupling patch and a preparation method thereof.
Background art:
at present, most of medical coupling agents are mainly liquid coupling agents, most of the coupling agents are irritant to sensitive skin, and a probe is in close contact with the skin, so that skin injury is easily caused. The liquid coupling agent is viscous, bubbles are easily generated in the smearing process, the conductivity to ultrasonic waves is low, and the obtained image is unclear. When the liquid coupling agent is used, the liquid coupling agent is easy to stick to skin and an instrument probe, is easy to stick to dirty clothes, is not easy to clean after being used, and is poor in dressing feeling when being used by a patient. The instrument probe is subject to wear, resulting in expensive maintenance. In addition, the odor of the ingredients in the couplant is large, the experience of a patient is influenced, the tension of the patient can be aggravated, the smearing uniformity of the couplant is difficult to control, the result is inaccurate, and the workload of doctors is increased.
The invention content is as follows:
in order to solve the technical problems, the invention provides a medical solid-state coupling patch and a preparation method thereof, which do not damage skin and instruments and equipment, are convenient to clean and have good detection effect.
The invention is realized by the following technical scheme:
the medical solid coupling patch is characterized by comprising a matrix material, a humectant, nano silver ionized water, purified water and a preservative, wherein the matrix material is one or more of carrageenan, konjac glucomannan, locust bean gum and gelatin, the mass percent of the matrix material is 2-10%, the mass percent of the humectant is 5-10%, the mass percent of the nano silver ionized water is 5-10%, the mass percent of the purified water is 70-87%, and the balance is the preservative.
In another aspect of the invention, the nano silver ion water is a uniform dispersion system containing 0.0001-0.001% of nano silver oxide powder, 0.05-0.15% of borosilicate and the balance of deionized water in percentage by mass.
In another aspect of the invention, the humectant is one or more of sodium hyaluronate, trehalose, propylene glycol, glycerin.
In another aspect of the invention, the preservative is cason.
A preparation method of a medical solid coupling patch is characterized by comprising the following steps:
step 1, respectively taking carrageenan, locust bean gum, gelatin, trehalose and glycerol, mixing and stirring for 10-20min to obtain a mixture A;
step 2, adding purified water into the mixture A obtained in the step 1, heating to 50-70 ℃, and stirring for 30min to obtain a mixture B;
step 3, adding silver oxide and borosilicate into deionized water in proportion, and preparing nano silver ion water with a uniform dispersion system under the rotating speed of keeping the stirring and shearing speed at 10000-15000 r/min;
step 4, adding a preservative and the nano silver ionized water obtained in the step 3 into the mixture B obtained in the step 2, stirring and mixing, pouring into a mold, and cooling to room temperature;
and 5, detecting the performance index of the product, and packaging under the condition of meeting a preset standard to obtain the coupling patch.
In another aspect of the invention, the product performance indicators in step 5 include thickness, weight, pH, number of bacteria, and clarity.
The invention has the beneficial effects that: the medical solid coupling patch can not damage skin and instrument equipment, is convenient to clean, has a good detection effect and a good antibacterial effect; when in use, the comfort of the patient is higher, and the detection operation of the doctor is relatively simple and more efficient. The preparation method of the medical solid coupling patch is simple and easy to operate, and is easy for large-scale production.
The specific implementation mode is as follows:
the following examples are presented to further illustrate embodiments of the present invention:
in describing the present invention, it is to be understood that the description indicating an orientation or positional relationship is merely for convenience in describing the present invention and for simplicity in description, and does not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be taken as limiting the scope of the present invention.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1
The components of the medical solid-state coupling patch comprise a matrix material, a humectant, nano silver ionized water, purified water and a preservative, wherein the matrix material is one or more of carrageenan, konjac glucomannan, locust bean gum and gelatin, in the embodiment, the matrix material is a mixture of carrageenan, locust bean gum and gelatin, the mass percent of the matrix material is 2%, the mass percent of the humectant is 5%, the mass percent of the nano silver ionized water is 5.5%, the mass percent of the purified water is 87%, and the balance is the preservative. The nano silver ion water is a uniform dispersion system containing 0.0001 mass percent of nano silver oxide powder, 0.05 mass percent of borosilicate and the balance of deionized water. The humectant is one or more of sodium hyaluronate, trehalose, propylene glycol and glycerol. The preservative is cason.
When the medical solid coupling patch is used, the medical solid coupling patch is applied to a to-be-detected position of a patient, bubbles between the patch and the skin are slightly squeezed and discharged by hands, the coupling patch is tightly attached to an instrument probe, and the medical solid coupling patch is slowly moved for detection.
The medical solid coupling patch is simple and convenient to use, can be taken and used immediately, can be operated by a doctor conveniently, and can improve the detection efficiency. The product has high water content, the components can not stimulate the skin of a patient, the skin and instrument and equipment can not be damaged, the cleaning is convenient, the detection effect is good, and the antibacterial effect is good. The medical solid coupling patch formula contains a proper amount of moisture-preserving components such as trehalose, glycerol and the like, and the patient has higher application performance and comfort.
Example 2
The components of the medical solid coupling patch comprise a matrix material, a humectant, nano silver ionized water, purified water and a preservative, wherein the matrix material is one or more of carrageenan, konjac glucomannan, locust bean gum and gelatin, in the embodiment, the matrix material is a mixture of carrageenan, locust bean gum and gelatin, the mass percent of the matrix material is 10%, the mass percent of the humectant is 9.5%, the mass percent of the nano silver ionized water is 10%, the mass percent of the purified water is 70%, and the balance is the preservative. The nano silver ion water is a uniform dispersion system containing 0.001% of nano silver oxide powder, 0.15% of borosilicate and the balance of deionized water in percentage by mass. The humectant is one or more of sodium hyaluronate, trehalose, propylene glycol and glycerol. The preservative is cason.
When the medical solid coupling patch is used, the medical solid coupling patch is applied to a to-be-detected position of a patient, bubbles between the patch and the skin are slightly squeezed and discharged by hands, the coupling patch is tightly attached to an instrument probe, and the medical solid coupling patch is slowly moved for detection.
The medical solid coupling patch is simple and convenient to use, can be taken and used immediately, can be operated by a doctor conveniently, and can improve the detection efficiency. The product has high water content, the components can not stimulate the skin of a patient, the skin and instrument and equipment can not be damaged, the cleaning is convenient, the detection effect is good, and the antibacterial effect is good. The medical solid coupling patch formula contains a proper amount of moisture-preserving components such as trehalose, glycerol and the like, and the patient has higher application performance and comfort.
Example 3
The components of the medical solid coupling patch comprise a matrix material, a humectant, nano silver ionized water, purified water and a preservative, wherein the matrix material is one or more of carrageenan, konjac glucomannan, locust bean gum and gelatin, in the embodiment, the matrix material is a mixture of carrageenan, locust bean gum and gelatin, the mass percent of the matrix material is 6.5%, the mass percent of the humectant is 10%, the mass percent of the nano silver ionized water is 5%, the mass percent of the purified water is 78%, and the balance is the preservative. The nano silver ion water is a uniform dispersion system which contains 0.0005 percent of nano silver oxide powder, 0.1 percent of borosilicate and the balance of deionized water by mass percent. The humectant is one or more of sodium hyaluronate, trehalose, propylene glycol and glycerol. The preservative is cason.
When the medical solid coupling patch is used, the medical solid coupling patch is applied to a to-be-detected position of a patient, bubbles between the patch and the skin are slightly squeezed and discharged by hands, the coupling patch is tightly attached to an instrument probe, and the medical solid coupling patch is slowly moved for detection.
The medical solid coupling patch is simple and convenient to use, can be taken and used immediately, can be operated by a doctor conveniently, and can improve the detection efficiency. The product has high water content, the components can not stimulate the skin of a patient, the skin and instrument and equipment can not be damaged, the cleaning is convenient, the detection effect is good, and the antibacterial effect is good. The medical solid coupling patch formula contains a proper amount of moisture-preserving components such as trehalose, glycerol and the like, and the patient has higher application performance and comfort.
Example 4
A preparation method of a medical solid coupling patch comprises the following steps:
step 1, respectively taking carrageenan, locust bean gum, gelatin, trehalose and glycerol, mixing and stirring for 10-20min to obtain a mixture A;
step 2, adding purified water into the mixture A obtained in the step 1, heating to 50-70 ℃, and stirring for 30min to obtain a mixture B;
step 3, adding silver oxide and borosilicate into deionized water in proportion, and preparing nano silver ion water with a uniform dispersion system under the rotating speed of keeping the stirring and shearing speed at 10000-15000 r/min;
step 4, adding a preservative and the nano silver ionized water obtained in the step 3 into the mixture B obtained in the step 2, stirring and mixing, pouring into a mold, and cooling to room temperature, wherein the shape and the size of the mold can be adjusted according to the specific situation of a patient part, and preferably, the shape of the mold can be square, round and the like;
and 5, detecting the performance index of the product, and packaging under the condition of meeting a preset standard to obtain the coupling patch.
The product performance indexes in the step 5 comprise thickness, weight, pH, bacterial quantity and transparency, and specifically, the product is transparent solid gel, and is free of bubbles and odor; pH: 6.0-7.0; weight: 10-20 g; the sound speed is 1520-1650 m/s; coli, total number of colonies and fungi yeast are not higher than 100 cfu/mL.
When in use, the product package is unpacked, the coupling patch is taken out, the coupling patch is applied to the position to be detected of a patient, and air bubbles between the patch and the skin are slightly squeezed and discharged by hands. And (5) tightly attaching the coupling patch with an instrument probe, and slowly moving for detection. The preparation method of the medical solid coupling patch is simple and easy to operate, and is easy for large-scale production.
In summary, the above-mentioned embodiments are only preferred embodiments of the present invention, and all equivalent changes and modifications made in the claims of the present invention should be covered by the claims of the present invention.
Claims (6)
1. The medical solid coupling patch is characterized by comprising a matrix material, a humectant, nano silver ionized water, purified water and a preservative, wherein the matrix material is one or more of carrageenan, konjac glucomannan, locust bean gum and gelatin, the mass percent of the matrix material is 2-10%, the mass percent of the humectant is 5-10%, the mass percent of the nano silver ionized water is 5-10%, the mass percent of the purified water is 70-87%, and the balance is the preservative.
2. The medical solid coupling patch according to claim 1, wherein the nano silver ionized water is a uniform dispersion system comprising 0.0001-0.001% by mass of nano silver oxide powder, 0.05-0.15% by mass of borosilicate, and the balance being deionized water.
3. The medical solid coupling patch as claimed in claim 1, wherein the humectant is one or more of sodium hyaluronate, trehalose, propylene glycol and glycerin.
4. The medical solid coupling patch according to claim 3, wherein the preservative is cason.
5. A preparation method of a medical solid coupling patch is characterized by comprising the following steps:
step 1, respectively taking carrageenan, locust bean gum, gelatin, trehalose and glycerol, mixing and stirring for 10-20min to obtain a mixture A;
step 2, adding purified water into the mixture A obtained in the step 1, heating to 50-70 ℃, and stirring for 30min to obtain a mixture B;
step 3, adding silver oxide and borosilicate into deionized water in proportion, and preparing nano silver ion water with a uniform dispersion system under the rotating speed of keeping the stirring and shearing speed at 10000-15000 r/min;
step 4, adding a preservative and the nano silver ionized water obtained in the step 3 into the mixture B obtained in the step 2, stirring and mixing, pouring into a mold, and cooling to room temperature;
and 5, detecting the performance index of the product, and packaging under the condition of meeting a preset standard to obtain the coupling patch.
6. The method for preparing a medical solid-state coupling patch according to claim 5, wherein the product performance index in step 5 comprises thickness, weight, pH, number of bacteria and transparency.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110468938.6A CN113230421A (en) | 2021-04-29 | 2021-04-29 | Medical solid coupling patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110468938.6A CN113230421A (en) | 2021-04-29 | 2021-04-29 | Medical solid coupling patch and preparation method thereof |
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|---|---|
| CN113230421A true CN113230421A (en) | 2021-08-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110468938.6A Pending CN113230421A (en) | 2021-04-29 | 2021-04-29 | Medical solid coupling patch and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009007266A (en) * | 2007-06-27 | 2009-01-15 | Shin-Ei Chemical Co Ltd | Silver ion water for cosmetic and low-irritant cosmetic using the same |
| CN105536005A (en) * | 2016-01-06 | 2016-05-04 | 深圳市敏浩科技有限公司 | Solid medical ultrasound coupling patch and preparing method thereof |
| US20160242736A1 (en) * | 2015-02-25 | 2016-08-25 | Decision Sciences Medical Company, LLC | Acoustic signal transmission couplants and coupling mediums |
| CN106456117A (en) * | 2014-04-24 | 2017-02-22 | 索诺法斯特股份公司 | Conductive medium pad for ultrasound probe |
| US20180055481A1 (en) * | 2015-05-20 | 2018-03-01 | Fujifilm Corporation | Coating-type contact medium for ultrasound diagnosis |
-
2021
- 2021-04-29 CN CN202110468938.6A patent/CN113230421A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009007266A (en) * | 2007-06-27 | 2009-01-15 | Shin-Ei Chemical Co Ltd | Silver ion water for cosmetic and low-irritant cosmetic using the same |
| CN106456117A (en) * | 2014-04-24 | 2017-02-22 | 索诺法斯特股份公司 | Conductive medium pad for ultrasound probe |
| US20160242736A1 (en) * | 2015-02-25 | 2016-08-25 | Decision Sciences Medical Company, LLC | Acoustic signal transmission couplants and coupling mediums |
| US20180055481A1 (en) * | 2015-05-20 | 2018-03-01 | Fujifilm Corporation | Coating-type contact medium for ultrasound diagnosis |
| CN105536005A (en) * | 2016-01-06 | 2016-05-04 | 深圳市敏浩科技有限公司 | Solid medical ultrasound coupling patch and preparing method thereof |
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Application publication date: 20210810 |
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