CN110420257A - A kind of compound mammilla of milk cattle dip and preparation method thereof - Google Patents
A kind of compound mammilla of milk cattle dip and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
Abstract
The invention belongs to mastitis for milk cows Prevention Technique fields, specifically disclose a kind of compound mammilla of milk cattle dip and preparation method thereof, by water, biguanide antimicrobial agent, emollient, thickener, alcohols, polyethylene glycol, Radix Notoginseng extracting solution, dark plum extracting solution, cloves extracting solution, pilose antler extracting solution, pigment and nonionic surfactant composition, the compound mammilla of milk cattle dip compounds other component composite bactericidals with the Chinese herbal medicine extract, high-efficiency broad spectrum, persistent, safety is without side-effects, it is not likely to produce drug resistance, dipping fluid viscosity is suitble to, anti-dripping melt is had excellent performance, layer protecting film can be formed in mammilla of milk cattle, effect is lasting, it can not only disinfecting skin-care, and it is short to solve traditional dip moisture preserving time, cause the problem that mammilla of milk cattle is dry and cracked.
Description
Technical field
The invention belongs to mastitis for milk cows Prevention Technique fields, and in particular to a kind of compound mammilla of milk cattle dip and its system
Preparation Method.
Background technique
Mastitis for milk cows be by multiple pathogenic microorganisms infection cause, be in Cow product it is most common, cause economic loss
One of maximum disease.The whole world caused by mastitis for milk cows every year because losing up to 35,000,000,000 dollars.People, which has eaten, suffers from mammitis milk cow
The milk of production can cause the symptoms such as diarrhea, vomiting and fever.Therefore reinforce to the anti-of mastitis for milk cows, especially recessive mastitis
It controls, is of great significance in production practice.
Milk cows symptom is the inflammation of mammary parenchyma, interstitial.The cause of disease is mostly immersed by mechanical irritation, pathogenic microorganism
And caused by the damage of chemicals rationality.The pathogenic microorganisms for the mastitis for milk cows being currently known is more than 150 kinds, including ball
Bacterium, bacillus, mycoplasma, fungi, saccharomycete and virus etc..Major part is as caused by bacterium infection, mainly by Gram-positive
Bacterium (such as Streptococcusagalactiae, staphylococcus aureus) causes, and Gram-negative bacteria (Escherichia coli) is also very general in large-scale cultivation
Time.The control measure being usually taken, which has, does milking health well, creates good sanitary condition, enhancing milk cow immunity etc..Do well
Health of milking is then most important one aspect, and it is relatively effective method that milking front and back, which carries out dipping to mammilla of milk cattle, at present.
There are many kinds of traditional dips, but due to some disinfectants (such as alcohol, hydrogen peroxide) to cow mammary gland skin and
Interior tissue has certain damage and stimulation by market, and the mammilla of milk cattle agent of current application is mainly iodine class disinfectant.
Such disinfectant generally uses polyvinylpyrrolidone, iodine, potassium iodide, glycerol, ethyl alcohol and thickener composition, can be at mammilla of milk cattle
Layer protecting film is formed, there is certain protective effect to nipple.But its existing defects: (1) glycerol moistening effect is easy by ring
The influence of border humidity, when envionmental humidity is too low, the effect for retaining hydrone can decline.In addition it is limited to the mechanism of itself,
The more difficult purpose for reaching efficient moisture-retention, long-time moistening effect is also undesirable, will cause the dry and cracked of cow papillary skin；(2) iodine
Preparation locally has slight of short duration stimulation to mammilla of milk cattle wound mucous membrane, and unstable under illumination and high temperature, bactericidal effect is short
Temporarily.
Chinese patent CN105582538A discloses a kind of drip proof type milk cow nipple medicated bath liquid, including following parts by weight
Component: 0.50 ~ 5.00 part of film forming agent, 0.10 ~ 0.50 part of thickener, 0.20 ~ 0.50 part of fungicide, skin conditioner 1.00 ~ 10.00
Part, 0.5 ~ 3.0 part of acidulant；The drip proof type milk cow nipple medicated bath liquid has viscosity high, and film forming speed is slow, forms a film thicker,
Cause skin of nipple airtight, keep skin of nipple tissue more fragile, is more easier to do using milking machine
The disadvantages of splitting.The patent of Chinese CN106727914A discloses a kind of milk cow nipple medicated bath liquid, and every kilogram of dip includes following
Components by weight percent: chitosan oligosaccharide 10-20g, n-trimethyl chitosan chloride 10-20g, dandelion extracting solution 50-80g, rosemary extracting solution 20-
30g, Radix Notoginseng extracting solution 20-30g, acetic acid 1-5g, glycerol 5-10g, surplus are medical purified water；The milk cow nipple medicated bath liquid is deposited
Dripping bad, cause to waste；Freezing point is higher, and solidification is easy at winter or low temperature, inconvenient for use；Bactericidal effect is not significant
The disadvantages of.
Summary of the invention
To solve the above problems, the present invention provides a kind of compound mammilla of milk cattle dip and preparation method thereof, it is described multiple
It closes milk cow nipple medicated bath liquid and other component composite bactericidals is compounded with the Chinese herbal medicine extract, high-efficiency broad spectrum, persistent, safety is without pair
Effect is not likely to produce drug resistance, and dipping fluid viscosity is suitble to, and anti-dripping melt is had excellent performance, and can form layer protecting film in mammilla of milk cattle,
Effect is lasting, can not only disinfecting skin-care, and it is short to solve traditional dip moisture preserving time, causes the problem that mammilla of milk cattle is dry and cracked.
Specific technical solution of the present invention is as follows:
A kind of compound mammilla of milk cattle dip, which is characterized in that the compound mammilla of milk cattle dip is former by following parts by weight
Material composition:
30 parts -50 parts of water
0.2 part -0.5 part of biguanide antimicrobial agent
1 part -10 parts of emollient
0.3 part -0.5 part of thickener
30 parts -50 parts of alcohols
0.3 part -0.5 part of polyethylene glycol
1 part -3 parts of Radix Notoginseng extracting solution
1 part -3 parts of dark plum extracting solution
1 part -3 parts of cloves extracting solution
0.01 part -0.05 part of pilose antler extracting solution
0.01 part -0.05 part of pigment
0.1 part -1 part of nonionic surfactant.
Preferably, the biguanide antimicrobial agent is in chlorhexidine acetate, chlorhexidine gluconate and poly hexamethylene biguanide
It is any or mixed by wherein any two kinds in the ratio of 1:0.1 ~ 50.
Preferably, the emollient is ethoxy urea, ceramide, allantoin, dexpanthenol and tremella extract
Any one of or mixed by wherein any two kinds in the ratio of 1:0.5 ~ 5.
Preferably, the thickener is xanthan gum, yellow thermophilic glue, curdlan, flaxseed gum, locust tree long bean, bulbil glue
And it is any or mixed by wherein any two kinds in the ratio of 1:0.1 ~ 20 in gellan gum.
Preferably, the alcohols be any one of ethyl alcohol, ethylene glycol and propylene glycol or by wherein any two kinds by 1:1
~ 10 ratio mixes.
Preferably, the pigment is light green, brilliant blue, indigo, lemon yellow, egg yolk or sunset yellow.
Preferably, the nonionic surfactant is alkyl glycosides, fatty alcohol polyoxyethylene ether and polyoxyethylene sorbitan
It any one of Span or is mixed by wherein any two kinds in the ratio of 1:0.5 ~ 20.
The preparation method of the compound mammilla of milk cattle dip the following steps are included:
(1) it fetches water by weight, is heated to 50 ~ 70 DEG C, keep water temperature constant, sequentially add polyethylene glycol, the profit of parts by weight
Skin agent and pigment, heating stirring obtain system A to dissolving；
(2) thickener is taken by weight, is added in the alcohol solution of parts by weight, after being uniformly dispersed, then the water of parts by weight is taken to add
Enter wherein, stirring is completely dissolved to thickener, obtains system B；
(3) by the system A and the biguanide antimicrobial agent of parts by weight, Radix Notoginseng extracting solution, dark plum extracting solution, cloves extracting solution, pilose antler
Extracting solution and nonionic surfactant sequentially add in the system B, stir while adding to uniformly, obtain described multiple
Close milk cow nipple medicated bath liquid.
The active group of biguanide antimicrobial agent of the present invention can be with the group or element phase in the Chinese herbal medicine extract
Mutually collaboration, improves the bactericidal bacteriostasis of dip, destroys the eubolism of bacterial virus, has broad-spectrum antiseptic, low concentration high
The characteristics of efficiency, sterilization rapidly, it is persistent, nontoxic, non-stimulated, touching at mammilla of milk cattle injury not will cause feeling of pain.
Emollient of the present invention has compared with conventional emollient (polyalcohols, natural moisturizing factor, amino acids)
More efficient lasting moisture-retaining capacity, the ethoxy urea, ceramide, allantoin, dexpanthenol and tremella extract list
One uses or is used in compounding, and can not only reach lasting moisturizing effect, and with other components matchings in component, can be formed a variety of
Substance formed double salt, have be protected from light, sterilization and anticorrosion, analgesic effect, can protect tissue, it is hydrophilic, absorb water and prevent moisture from distributing,
Skin can be made to keep moisture content, moistened and soft.
Alcohols of the present invention and polyethylene glycol cooperate, and system freezing point can be effectively reduced, while playing dissolution assistant effect,
Adjustable system liquidity energy, compounds with thickener selected by the present invention, overcomes the contradiction between anti-drip and viscosity, makes
Mammilla of milk cattle dips in one layer of uniform and thin dip, and while guaranteeing bactericidal effect, dosage is few, does not drip and is able to satisfy milk cow
Gas permeability needed for nipple.
Radix Notoginseng extracting solution of the present invention, dark plum extracting solution, cloves extracting solution, pilose antler extracting solution compounding, good penetrability have
Anti-inflammatory, inducing astrigency, effect that is antibacterial, promoting collagen synthesis, are mutually improved effect with biguanide antimicrobial agent selected by the present invention, and two
Person's compounding can achieve long-acting bactericidal, improve the effect of milk cow self-defensive system defense function.Radix Notoginseng extracting solution can promoting blood circulation
The stasis of blood, anti-inflammatory, the effect of dark plum extracting solution inducing astrigency, bacteriostasis are excellent, and the two compounding can promote milk duct healing, shorten cream after milking
Conduit is opened a business the time, and the chance of bacterium intrusion is significantly reduced.Cloves extracting solution has analgesic, anti-inflammatory, bacteriostasis, mentions with dark plum
It takes liquid to have synergic remove, and mammilla of milk cattle injury can be made to be in calm comfortable state.Deer antler extract can promote glue
The synthesis of former albumen promotes wound healing, the function of " the first line of defence " of enhancing prevention pathogenic microorganism invasion.
The invention has the advantages that:
(1) compound mammilla of milk cattle dip of the present invention is cooperated with Chinese herbal medicine extract and other components, gained dipping
Liquid is had excellent performance with anti-dripping melt, and system flowing is not sticky, easily the advantages of mammilla of milk cattle surface forms layer protecting film, can be held
Sterilization, antibacterial and antibacterial long, and keep mammilla of milk cattle is wet not dry, there is good moisturizing skin effect, solve tradition
Dip moisture preserving time is short, is easy drippage, easily causes the problem that mammilla of milk cattle is dry and cracked；
(2) compound mammilla of milk cattle dip freezing point of the present invention is low, not-easy-to-freeze at low ambient temperatures, is easy to use, and solves
Traditional mammilla of milk cattle protective agent freezing point is higher, and low temperature easily solidifies problem not easy to use；
(3) compound mammilla of milk cattle dip high-efficiency broad spectrum of the present invention, persistent, safety is without side-effects, is not likely to produce anti-
Pharmacological property also improves milk cow self-defensive system defense function while improving dip nipple protecting effect.
Specific embodiment
Embodiment 1
A kind of compound mammilla of milk cattle dip, is composed of the following raw materials by weight:
30 parts of water
0.2 part of biguanide antimicrobial agent
1 part of emollient
0.3 part of thickener
30 parts of alcohols
0.3 part of polyethylene glycol
1 part of Radix Notoginseng extracting solution
1 part of dark plum extracting solution
1 part of cloves extracting solution
0.01 part of pilose antler extracting solution
0.01 part of pigment
0.1 part of nonionic surfactant
Wherein, the biguanide antimicrobial agent is chlorhexidine acetate；The emollient is ethoxy urea；The thickener is xanthan
Glue；The alcohols is ethyl alcohol；
The pigment is light green；
The nonionic surfactant is alkyl glycosides；
The preparation method of the compound mammilla of milk cattle dip the following steps are included:
(1) it fetches water by weight, is heated to 50 DEG C, keep water temperature constant, sequentially add polyethylene glycol, the ethoxy of parts by weight
Urea and light green pigment, heating stirring obtain system A to dissolving；
(2) xanthan gum is taken by weight, is added in the ethanol solution of parts by weight, after being uniformly dispersed, then the water of parts by weight is taken to add
Enter wherein, stirring is completely dissolved to xanthan gum, obtains system B；
(3) by the system A and the chlorhexidine acetate of parts by weight, Radix Notoginseng extracting solution, dark plum extracting solution, cloves extracting solution, pilose antler
Extracting solution and alkyl glycosides sequentially add in the system B, stir while adding to uniformly, obtain the composite milk cow's milk
Head dip.
Embodiment 2
A kind of compound mammilla of milk cattle dip, is composed of the following raw materials by weight:
50 parts of water
0.5 part of biguanide antimicrobial agent
10 parts of emollient
0.5 part of thickener
50 parts of alcohols
0.5 part of polyethylene glycol
3 parts of Radix Notoginseng extracting solution
3 parts of dark plum extracting solution
3 parts of cloves extracting solution
0.05 part of pilose antler extracting solution
0.05 part of pigment
1 part of nonionic surfactant
Wherein, the biguanide antimicrobial agent is chlorhexidine gluconate；The emollient is allantoin；The thickener is that can obtain so
Glue；
The alcohols ethylene glycol；
The pigment is brilliant blue；
The nonionic surfactant is fatty alcohol polyoxyethylene ether；
The preparation method of the compound mammilla of milk cattle dip the following steps are included:
(1) it fetches water by weight, is heated to 70 DEG C, keep water temperature constant, sequentially add polyethylene glycol, the allantoin of parts by weight
And brilliant blue pigment, heating stirring obtain system A to dissolving；
(2) curdlan is taken by weight, is added in the ethylene glycol solution of parts by weight, after being uniformly dispersed, then takes parts by weight
Water is added thereto, and stirring is completely dissolved to curdlan, obtains system B；
(3) by the system A and the chlorhexidine gluconate of parts by weight, Radix Notoginseng extracting solution, dark plum extracting solution, cloves extracting solution,
Pilose antler extracting solution and fatty alcohol polyoxyethylene ether sequentially add in the system B, stir while adding to uniformly, obtain institute
State compound mammilla of milk cattle dip.
Embodiment 3
A kind of compound mammilla of milk cattle dip, is composed of the following raw materials by weight:
45 parts of water
0.3 part of biguanide antimicrobial agent
5 parts of emollient
0.4 part of thickener
40 parts of alcohols
0.4 part of polyethylene glycol
2 parts of Radix Notoginseng extracting solution
2 parts of dark plum extracting solution
2 parts of cloves extracting solution
0.03 part of pilose antler extracting solution
0.03 part of pigment
0.7 part of nonionic surfactant
Wherein, the biguanide antimicrobial agent is poly hexamethylene biguanide；
The emollient is dexpanthenol；
The thickener is flaxseed gum；
The alcohols is propylene glycol；
The pigment is lemon yellow；
The nonionic surfactant is polyoxyethylene sorbitan fatty acid ester；
The preparation method of the compound mammilla of milk cattle dip the following steps are included:
(1) it fetches water by weight, is heated to 60 DEG C, keep water temperature constant, sequentially add polyethylene glycol, the vitamin of parts by weight
Former B5 and lemon yellow pigment, heating stirring obtain system A to dissolving；
(2) flaxseed gum is taken by weight, is added in the propylene glycol solution of parts by weight, after being uniformly dispersed, then takes parts by weight
Water is added thereto, and stirring is completely dissolved to flaxseed gum, obtains system B；
(3) by the system A and the poly hexamethylene biguanide of parts by weight, Radix Notoginseng extracting solution, dark plum extracting solution, cloves extracting solution,
Pilose antler extracting solution and polyoxyethylene sorbitan fatty acid ester sequentially add in the system B, stir while adding to uniform
, obtain the compound mammilla of milk cattle dip.
Embodiment 4
A kind of compound mammilla of milk cattle dip, is composed of the following raw materials by weight:
35 parts of water
0.35 part of biguanide antimicrobial agent
6 parts of emollient
0.35 part of thickener
35 parts of alcohols
0.45 part of polyethylene glycol
2.5 parts of Radix Notoginseng extracting solution
1.5 parts of dark plum extracting solution
1.8 parts of cloves extracting solution
0.04 part of pilose antler extracting solution
0.035 part of pigment
0.8 part of nonionic surfactant
Wherein, the biguanide antimicrobial agent is that chlorhexidine acetate and chlorhexidine gluconate are formed in the ratio mixing of 1:0.1；
The emollient is that ceramide and allantoin are mixed in the ratio of 1:0.5；
The thickener is that yellow thermophilic glue and locust tree long bean are mixed in the ratio of 1:0.1；
The alcohols is that ethyl alcohol and ethylene glycol are formed in the ratio mixing of 1:1；
The pigment is indigo；
The nonionic surfactant is that alkyl glycosides and fatty alcohol polyoxyethylene ether are formed in the ratio mixing of 1:0.5；
The preparation method of the compound mammilla of milk cattle dip the following steps are included:
(1) it fetches water by weight, is heated to 50 DEG C, keep water temperature constant, sequentially add polyethylene glycol, the neural acyl of parts by weight
Amine and allantoin mixture and indigo pigment, heating stirring obtain system A to dissolving；
(2) yellow thermophilic glue and locust tree long bean are taken by weight, is added to the ethyl alcohol of parts by weight and the mixed solution of ethylene glycol, and dispersion is equal
After even, then the water of parts by weight is taken to be added thereto, stirring to yellow thermophilic glue is completely dissolved with locust tree long bean, obtains system B；
(3) by the system A and the chlorhexidine acetate of parts by weight and chlorhexidine gluconate mixture, Radix Notoginseng extracting solution, dark plum
The mixture of extracting solution, cloves extracting solution, pilose antler extracting solution and alkyl glycosides and fatty alcohol polyoxyethylene ether sequentially adds described
In system B, stirs while adding to uniformly, obtain the compound mammilla of milk cattle dip.
Embodiment 5
A kind of compound mammilla of milk cattle dip, which is characterized in that the compound mammilla of milk cattle dip is former by following parts by weight
Material composition:
45 parts of water
0.45 part of biguanide antimicrobial agent
4 parts of emollient
0.42 part of thickener
38 parts of alcohols
0.42 part of polyethylene glycol
1.5 parts of Radix Notoginseng extracting solution
2.3 parts of dark plum extracting solution
2.5 parts of cloves extracting solution
0.03 part of pilose antler extracting solution
0.045 part of pigment
0.4 part of nonionic surfactant
Wherein, the biguanide antimicrobial agent is the ratio mixing composition of chlorhexidine gluconate and poly hexamethylene biguanide in 1:50；
The emollient is that dexpanthenol and tremella extract are mixed in the ratio of 1:5；
The thickener is that flaxseed gum and bulbil glue are mixed in the ratio of 1:20；
The alcohols is that ethylene glycol and propylene glycol are formed in the ratio mixing of 1:10；
The pigment is egg yolk；
The nonionic surfactant is that fatty alcohol polyoxyethylene ether and polyoxyethylene sorbitan fatty acid ester press 1:20
Ratio mixing composition；
The preparation method of the compound mammilla of milk cattle dip the following steps are included:
(1) it fetches water by weight, is heated to 70 DEG C, keep water temperature constant, sequentially add polyethylene glycol, the vitamin of parts by weight
Former B5 and tremella extract mixture and egg uranidin, heating stirring obtain system A to dissolving；
(2) flaxseed gum and bulbil glue are taken by weight, are added in the ethylene glycol and mixed with propylene glycol solution of parts by weight, point
After dissipating uniformly, then the water of parts by weight is taken to be added thereto, stirring is completely dissolved to flaxseed gum and bulbil glue, obtains system B；
(3) by the chlorhexidine gluconate and poly hexamethylene biguanide mixture of the system A and parts by weight, Radix Notoginseng extracting solution,
Dark plum extracting solution, cloves extracting solution, pilose antler extracting solution and fatty alcohol polyoxyethylene ether and polyoxyethylene sorbitan fatty acid
Ester admixture sequentially adds in the system B, stirs while adding to uniformly, obtains the compound milk cow nipple medicated bath
Liquid.
Embodiment 6
A kind of compound mammilla of milk cattle dip, is composed of the following raw materials by weight:
32 parts of water
0.2 part of biguanide antimicrobial agent
7 parts of emollient
0.38 part of thickener
42 parts of alcohols
0.42 part of polyethylene glycol
2 parts of Radix Notoginseng extracting solution
2 parts of dark plum extracting solution
1.8 parts of cloves extracting solution
0.03 part of pilose antler extracting solution
0.04 part of pigment
0.7 part of nonionic surfactant
Wherein, the biguanide antimicrobial agent is that chlorhexidine acetate and poly hexamethylene biguanide are formed in the ratio mixing of 1:25；
The emollient is that allantoin and tremella extract are mixed in the ratio of 1:3；
The thickener is that flaxseed gum and gellan gum are mixed in the ratio of 1:10；
The alcohols is that ethyl alcohol and propylene glycol are formed in the ratio mixing of 1:6；
The pigment is sunset yellow；
The nonionic surfactant is that alkyl glycosides and polyoxyethylene sorbitan fatty acid ester are mixed in the ratio of 1:10
It is combined into；
The preparation method of the compound mammilla of milk cattle dip the following steps are included:
(1) it fetches water by weight, is heated to 60 DEG C, keep water temperature constant, sequentially add polyethylene glycol, the allantoin of parts by weight
With tremella extract mixture and sunset yellow, heating stirring obtains system A to dissolving；
(2) flaxseed gum and gellan gum are taken by weight, is added in the ethyl alcohol and mixed with propylene glycol solution of parts by weight, and dispersion is equal
After even, then the water of parts by weight is taken to be added thereto, stirring is completely dissolved to flaxseed gum and gellan gum, obtains system B；
(3) by the system A and the chlorhexidine acetate of parts by weight and poly hexamethylene biguanide mixture, Radix Notoginseng extracting solution, dark plum
Extracting solution, cloves extracting solution, pilose antler extracting solution and alkyl glycosides and polyoxyethylene sorbitan fatty acid ester mixture are successively
It is added in the system B, stirs while adding to uniformly, obtain the compound mammilla of milk cattle dip.
Embodiment 7
Difference with embodiment 6 is:
The biguanide antimicrobial agent is that chlorhexidine acetate and chlorhexidine gluconate are formed in the ratio mixing of 1:35；
The emollient is that ethoxy urea and allantoin are mixed in the ratio of 1:2；
The thickener is that curdlan and locust tree long bean are mixed in the ratio of 1:8；
The alcohols is that ethyl alcohol and propylene glycol are formed in the ratio mixing of 1:7；
The nonionic surfactant is that alkyl glycosides and fatty alcohol polyoxyethylene ether are formed in the ratio mixing of 1:15.
Embodiment 8
Difference with embodiment 7 is:
The biguanide antimicrobial agent is that chlorhexidine acetate and poly hexamethylene biguanide are formed in the ratio mixing of 1:25；
The emollient is that allantoin and tremella extract are mixed in the ratio of 1:2.5；
The thickener is that flaxseed gum and gellan gum are mixed in the ratio of 1:12.
Comparative experiments
Laboratory sample 1: the compound milk nipple dip of the preparation gained of embodiment 1；
Laboratory sample 2: the compound milk nipple dip of the preparation gained of embodiment 4；
Laboratory sample 3: the compound milk nipple dip of the preparation gained of embodiment 5；
Laboratory sample 4: dip component includes: deionized water, povidone-iodine, glycerol, guar gum and ethyl alcohol, the amounts of components
Respectively successively according to component described in embodiment 1: water, biguanide antimicrobial agent, emollient, thickener and alcohols parts by weight weigh,
The preparation method is the same as that of Example 1, gained dip；
Laboratory sample 5: according to Chinese patent CN105582538A drip proof type milk cow nipple medicated bath liquid announced and preparation method thereof
Technical solution preparation gained dip；
Laboratory sample 6: it is weighed according to the technical solution of the Chinese patent CN106727914A milk cow nipple medicated bath liquid announced described
Component prepares gained dip by preparation method described in embodiment 1；
Experimental method: anti-from the anti-dripping melt of above-mentioned laboratory sample 1 ~ 6, bactericidal properties, moisture retention, milk cow self-defensive system respectively
Defending six function, freezing point, clinical effectiveness aspects can be carried out evaluation to its progressive, specific as follows:
(1) sterilization experiment
Experimental method:
It tests the preparation of bacterium solution: staphylococcus aureus, Streptococcusagalactiae, streptococcus dysgalactiae, Escherichia coli is inoculated into respectively
After nutrient agar culture for 24 hours, then by S. aureus Inoculate to nutrient broth medium, Streptococcusagalactiae and stop
Streptococcus lactis is seeded to blood agar medium, and Escherichia coli are inoculated into LB culture medium, and 37 DEG C of cultures 18~for 24 hours, it is spare；
Above-mentioned bacterium solution is divided into 4 groups, is respectively as follows: A group staphylococcus aureus experimental group, B group Streptococcusagalactiae experimental group, C group
Streptococcus dysgalactiae experimental group, D group Escherichia coli experimental group；Every group of experiment is equipped with 6 reaction tubes, and every group of every pipe is separately added into 1mL
Corresponding bacterium solution；After every group of 6 reaction tubes are successively separately added into test specimen 1 ~ 6, respectively in the 5th, 10,15,20,25,30s
When take the bacterium solution 1mL of 4 groups of 26 reaction tubes, 9mL neutralizer is added, shakes up, after neutralizing 10min, taking out 1mL, that 9mL is added is corresponding
Fluid nutrient medium, be put into after shaking up 37 DEG C of insulating box culture for 24 hours, the growing state of bacterium in each pipe is observed, as a result such as 1 institute of table
Show:
By above-mentioned experimental result it is found that technical solution of the present invention is easier more to kill staphylococcus aureus, agalasisa rapidly
Streptococcus, streptococcus dysgalactiae and Escherichia coli, sterilization quickly, are used for mammilla of milk cattle anti-inflammation and sterilization, it is easier to achieve the goal；
(2) anti-dripping melt performance test
Experimental method: taking 6 identical glass bars and 6 identical beakers, is successively labeled as glass bar 1 ~ 6, and
The glass bar for marking same numbers and beaker are formed one group, obtain experimental group A ~ F by beaker 1 ~ 6, respectively that 6 glass bars are same
When loading test sample 1 ~ 6 dip sample, after stopping 5s, remove simultaneously, hang on above corresponding beaker, record every group with stopwatch
The Drain time of the every drop of sample finally removes average Drain time；
Average Drain time=total used time after last drop Drain time/always drips number
And calculate every group of effective component retention rate:
Effective component storage rate=(dip quality-drippage quality)/dip quality × 100%
Wherein, it dips quality=laboratory sample quality-and dips rear laboratory sample quality；
Beaker quality-sky beaker quality after drippage quality=test；
Experimental result is as shown in table 2:
By 2 experimental result of table it is found that dip adhesiveness of the present invention is less than dip obtained by prior art, but it is average
Drain time and effective component storage rate are much larger than the prior art, and illustrating dip of the present invention, not only viscosity is small, save
Usage amount, and anti-dripping melt is had excellent performance, and persistently can effectively rest on body surface, reaches lasting antibacterial, sterilization and skin care effect
Fruit；
(3) dip freezing point is tested
Measuring instrument: freezing point tester
Test method: the refractive prism of freezing point tester is directed at bright direction, eyepiece diopter ring is adjusted, until graticule is clearly
Only, tester is calibrated, is overlapped the line of demarcation Lan Bai in eyepiece field of view with reference line.3 drop samples are taken when test
It drips and presses lightly on refractive prism, covering cover board, reading the corresponding scale in the line of demarcation Lan Bai is measurement result；
Experimental result is as shown in table 3:
By above-mentioned test result it is found that dip freezing point of the present invention is resulting far below prior art preparation, illustrate this hair
The bright dip freezing point is low, and system is not easy to be affected by the external environment, and is easy to use；
(4) performance of keeping humidity is tested
Test apparatus: moisture of skin tester
The back of the hand is divided into the region of 6 pieces of same sizes, is cleaned up, test value moisture value is constant；Laboratory sample 1 ~ 6 is taken into phase
Same amount is applied to 6 pieces of regions respectively, starts timing afterwards, and probe of tester was vertically pressed in tested skin surface every 30 minutes, reads
It moisture of skin numerical value and records out.Test is carried out 3 times, corresponding time point is averaged.Test is finished every time, and washing is clean,
To skin nature rest and reorganization 3h.The results are shown in Table 4 for record:
By 4 humidity Value Data of table it is found that dip test specimen 1 ~ 3 of the present invention much higher than other dip test specimens 4 ~
6, and humidity value illustrates that dip performance of keeping humidity of the present invention is good and the duration is long without being substantially reduced in 180min；
(5) clinical trial
The milk cow that 120 physical condition indifferences are chosen in Shaanxi pasture is subjects, and 120 cow heads are divided into A ~ F group 6
Group, every group 20, milking daily twice, every time after milking, successively smears test specimen 1 ~ 6 in 6 groups of mammilla of milk cattle of A ~ F group respectively
Dip, and the somatic number in the milk sample after milking every time is measured, after Therapy lasted one month, while deactivating dip；In
Mammilla of milk cattle situation is recorded during experiment respectively, and is measured using the body cell in one month and deactivated one week milk sample of dip
Several and recessive mastitis disease incidence, the results are shown in Table 5:
It can be seen that the nipple dip wetting invented using the technical program for one month on probation from the above clinical test results to make
With more preferable；Recessive mastitis disease incidence is lower；Somatic number is substantially reduced than control group, illustrates the cream of nipple dip of the present invention
Glandular tissue repairing effect is preferable.It is discontinued after a week, dip obtained by the prior art mammilla of milk cattle chap occurs or turns up, and hidden
Property mammitis disease incidence rise, and the present invention provides nipple dip and is being discontinued after a week, and mammilla of milk cattle is recessive without obvious abnormal
Mammitis disease incidence is still lower, illustrates that dip of the present invention has positive effect to milk cow self-defense function is improved；
By above-mentioned experimental result it is found that compound milk cow nipple medicated bath liquid of the present invention, no matter from bactericidal properties, anti-dripping melt is new, protects
Dip obtained by the prior art is superior in terms of wet performance or low temperature resistance, and clinical trial results are in skin care, antibacterial
It is more excellent compared with the prior art with prevention and treatment inflammation recurrence etc..
Claims (8)
1. a kind of compound mammilla of milk cattle dip, which is characterized in that the compound mammilla of milk cattle dip is by following parts by weight
Raw material composition:
30 parts -50 parts of water
0.2 part -0.5 part of biguanide antimicrobial agent
1 part -10 parts of emollient
0.3 part -0.5 part of thickener
30 parts -50 parts of alcohols
0.3 part -0.5 part of polyethylene glycol
1 part -3 parts of Radix Notoginseng extracting solution
1 part -3 parts of dark plum extracting solution
1 part -3 parts of cloves extracting solution
0.01 part -0.05 part of pilose antler extracting solution
0.01 part -0.05 part of pigment
0.1 part -1 part of nonionic surfactant.
2. compound mammilla of milk cattle dip according to claim 1, which is characterized in that the biguanide antimicrobial agent be acetic acid chlorine oneself
Any one of fixed, chlorhexidine gluconate and poly hexamethylene biguanide or by wherein any two kinds of ratios in 1:0.1 ~ 50
It mixes.
3. compound mammilla of milk cattle dip according to claim 1, which is characterized in that the emollient be ethoxy urea,
Any one of ceramide, allantoin, dexpanthenol and tremella extract or by wherein any two kinds by 1:0.5 ~ 5
Ratio mixes.
4. compound mammilla of milk cattle dip according to claim 1, which is characterized in that the thickener is xanthan gum, Huang is thermophilic
In glue, curdlan, flaxseed gum, locust tree long bean, bulbil glue and gellan gum it is any or by wherein any two kinds press 1:
0.1 ~ 20 ratio mixes.
5. compound mammilla of milk cattle dip according to claim 1, which is characterized in that the alcohols be ethyl alcohol, ethylene glycol and
It any one of propylene glycol or is mixed by wherein any two kinds in the ratio of 1:1 ~ 10.
6. compound mammilla of milk cattle dip according to claim 1, which is characterized in that the pigment is light green, brilliant blue, indigo
Indigo plant, lemon yellow, egg yolk or sunset yellow.
7. compound mammilla of milk cattle dip according to claim 1, which is characterized in that the nonionic surfactant is alkane
Any one of base glucosides, fatty alcohol polyoxyethylene ether and polyoxyethylene sorbitan fatty acid ester or by wherein any two
Kind mixes composition in the ratio of 1:0.5 ~ 20.
8. a kind of preparation method of compound mammilla of milk cattle dip as described in claim 1, which is characterized in that including following step
It is rapid:
(1) it fetches water by weight, is heated to 50 ~ 70 DEG C, keep water temperature constant, sequentially add polyethylene glycol, the moisturizing of parts by weight
Agent and pigment, heating stirring obtain system A to dissolving；
(2) thickener is taken by weight, is added in the alcohol solution of parts by weight, after being uniformly dispersed, then the water of parts by weight is taken to add
Enter wherein, stirring is completely dissolved to thickener, obtains system B；
(3) by the system A and the biguanide antimicrobial agent of parts by weight, Radix Notoginseng extracting solution, dark plum extracting solution, cloves extracting solution, pilose antler
Extracting solution and nonionic surfactant sequentially add in the system B, stir while adding to uniformly, obtain described multiple
Close milk cow nipple medicated bath liquid.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112245511A (en) * | 2020-10-16 | 2021-01-22 | 广州汇芬生物科技有限公司 | Pet disinfectant and preparation method thereof |
| CN113509435A (en) * | 2021-07-23 | 2021-10-19 | 天津华源化工有限公司 | Formula for nursing cow nipples and production method thereof |
| CN114652767A (en) * | 2022-04-28 | 2022-06-24 | 河北科技大学 | Medicated bath agent for nipples of dairy cows and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596235A (en) * | 2016-01-11 | 2016-05-25 | 西安汉隆化工科技有限公司 | Novel milk cow nipple medicated bath solution and preparing method thereof |
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2019
- 2019-08-30 CN CN201910813587.0A patent/CN110420257B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596235A (en) * | 2016-01-11 | 2016-05-25 | 西安汉隆化工科技有限公司 | Novel milk cow nipple medicated bath solution and preparing method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112245511A (en) * | 2020-10-16 | 2021-01-22 | 广州汇芬生物科技有限公司 | Pet disinfectant and preparation method thereof |
| CN113509435A (en) * | 2021-07-23 | 2021-10-19 | 天津华源化工有限公司 | Formula for nursing cow nipples and production method thereof |
| CN114652767A (en) * | 2022-04-28 | 2022-06-24 | 河北科技大学 | Medicated bath agent for nipples of dairy cows and preparation method thereof |
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