CN113197835A

CN113197835A - Acne removing additive and skin care product

Info

Publication number: CN113197835A
Application number: CN202110510710.9A
Authority: CN
Inventors: 任巍; 王正亚
Original assignee: Guangzhou Yanzhi Cosmetics Co ltd
Current assignee: Guangzhou Yanzhi Cosmetics Co ltd
Priority date: 2021-05-11
Filing date: 2021-05-11
Publication date: 2021-08-03
Anticipated expiration: 2041-05-11
Also published as: CN113197835B

Abstract

The invention discloses an acne-removing additive and a skin care product, wherein the active ingredients of the acne-removing additive comprise inactivated lactobacillus, yacon root juice, inonotus obliquus plant peptide, perilla seed extract, eucalyptus globulus leaf extract, barley seed extract, sodium hyaluronate and beta-glucan. The acne-removing additive provided by the invention can effectively inhibit the growth of harmful bacteria, promote the growth of beneficial bacteria of the skin, maintain the balance of skin micro-ecology, create a good micro-ecological environment for the skin and further reduce the generation of skin diseases.

Description

Acne removing additive and skin care product

Technical Field

The invention relates to the biological industry, in particular to a natural plant extract, and particularly relates to a plant extract composition with an acne removing function and a skin care product.

Background

Acne, comedo and pimple are collectively called as acne in medicine, and are common sebaceous gland chronic diseases, pimple mostly occurs in adolescence (about 16-30 years old), most of pimples are self-healed after adolescence, the morbidity of males is higher than that of females, and summer is more than that of winter. The hair-growing part is skin rich in sebaceous glands on the face, the upper chest and the back.

It is generally believed that the following factors contribute to the formation of pimples:

1) in vivo, the male hormone is over-secreted, the sebaceous gland is enlarged, the sebum is over-secreted and is not excreted smoothly, and the sebum is accumulated in hair follicles to form lipid plugs. Prolonged secondary bacterial infection causes inflammatory reactions around the pilosebaceous glands, forming papules or pustules, i.e. pimples.

2) The disease is genetically related and generally has a family history.

3) Endocrine disorders, dyspepsia, nervous system disorders. The ingestion of high-fat, high-sugar foods and spicy foods are the causes of the diseases.

4) There are other diseases that cause the excretion of toxins in the body to cause acne, most commonly constipation. Untimely or improper skin cleaning and nursing. For example, over-cleansing of the skin results in loss of weak acid protection of the natural sebum membrane of the skin leading to bacterial infection and acne growth, and untimely exfoliation results in a thick stratum corneum which builds up too thick, blocks pores leading to bacterial infection.

The types of acne-removing cosmetics on the market are various at present, but the following problems are generally existed:

1) to pursue the effect, the product contains the forbidden components: according to the cosmetic spot inspection announcement of the State food and drug administration, in recent years, a plurality of batches of acne-removing cosmetics are detected to contain glucocorticoid components such as betamethasone, clobetasol propionate and the like, and the components are also specified as forbidden substances in the cosmetics in technical Specification for cosmetic safety (2015 edition). The published data show that glucocorticoid has anti-inflammatory and immunosuppressive effects and can restore skin to white and tender within a short period of time, but long-term use of cosmetics containing glucocorticoid may result in damage to skin barrier, generation of black spots, atrophy and thinning, and the like, and also may easily cause consequences such as hormone-dependent dermatitis and the like.

2) The acne-removing product generally contains the bactericide, can kill most flora on the surface of the skin, has quick response, but destroys the micro-ecological environment of the skin, kills harmful flora (such as propionibacterium acnes, staphylococcus aureus and the like), kills beneficial flora (mainly lactobacillus), can cause the micro-ecology of the skin to be destroyed, competitively inhibits the loss of the function of the harmful flora, and leads the skin to be in a susceptible state, thus causing the acne to be easily repeated.

3) The acne removing function is not comprehensive enough, so that the effect is not satisfactory.

The development of a safe and effective acne-removing additive has very practical significance.

Plant extracts generally have better safety and can improve skin conditions. Different plant extracts often have different effects, and meanwhile, the plant extracts have various components, so that if the additive and the skin care product with excellent acne removing effect are prepared by using the plant extracts, the method is challenging work.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides an acne-removing additive mainly adopting plant extracts and a corresponding skin care product.

The technical scheme adopted by the invention is as follows:

in a first aspect of the present invention, there is provided:

an additive for removing acne comprises active ingredients including inactivated lactobacillus, yacon root juice, Fuscoporia Obliqua plant peptide, fructus Perillae extract, folium Eucalypti Globueli extract, semen Hordei vulgaris extract, sodium hyaluronate, and beta-dextran.

In some examples of the acne-removing additive, the active ingredients are as follows in parts by weight: inactivating the lactobacillus: 0.01-1 part of yacon root juice: 0.1-10 parts of inonotus obliquus plant peptide: 0.1-2 parts of perilla seed extract, 0.1-5 parts of eucalyptus globulus leaf extract, 0.1-5 parts of barley seed extract: 0.1-5 parts of sodium hyaluronate: 0.1-1 part of beta-glucan: 0.1 to 0.6 portion.

In some examples of the acne-removing additive, the active ingredients are as follows in parts by weight: inactivating the lactobacillus: 0.1-1 part of yacon root juice: 1-5 parts of inonotus obliquus plant peptide: 0.5-2 parts of perilla seed extract, 1-5 parts of eucalyptus globulus leaf extract, and barley seed extract: 1-5 parts of sodium hyaluronate: 0.1-1 part of beta-glucan: 0.1 to 0.6 portion.

In some examples of anti-acne additives, the lactobacillus consists of lactobacillus casei and lactobacillus acidophilus.

In some examples of anti-acne additives, the mass ratio of lactobacillus casei to lactobacillus acidophilus is 1: (0.5-2).

In a second aspect of the present invention, there is provided:

a skin care product is added with the acne removing additive of the first aspect of the invention.

In some examples of the skin care product, the acne-removing additive comprises the following active ingredients in percentage by mass:

inactivating the lactobacillus: 0.1 to 1 percent

The yacon root juice: 1 to 5 percent

Fuscoporia obliqua plant peptide: 0.5 to 2 percent

1-5% of perilla seed extract

1-5% of eucalyptus globulus leaf extract

Barley seed extract: 1 to 5 percent

Sodium hyaluronate: 0.1 to 1 percent

Beta-glucan: 0.1 to 0.6 percent.

In some examples of skin care products, the skin care product is a serum.

In some skin care product examples, the base of the serum is EDTA-2 sodium 0.05%, pentanediol 2%, hexanediol 0.5%, butanediol 4%, carbomer 0.3%, arginine 0.3%.

In some skin care products, the components of the essence comprise the following components in percentage by mass:

inactivating the lactobacillus: 1 percent of

The yacon root juice: 5 percent of

Fuscoporia obliqua plant peptide: 2 percent of

Perilla seed extract 5%

Eucalyptus globulus leaf extract 5%

Barley seed extract: 5 percent of

Sodium hyaluronate: 1 percent of

Beta-glucan: 0.6 percent

EDTA-2 sodium 0.05%

2 percent of pentanediol

0.5 percent of hexanediol

4 percent of butanediol

Carbomer 0.3%

Arginine 0.3%

The balance being deionized water.

In some examples of skin care products, the lactobacillus is prepared by mixing lactobacillus with a mixture of lactobacillus and lactobacillus in a mass ratio of 1: 1 of lactobacillus casei and lactobacillus acidophilus.

The invention has the beneficial effects that:

the acne-removing additive disclosed by the invention has a good synergistic effect, has a good acne-removing effect when added into a skin care product, and is basically non-irritant to skin and good in safety.

The acne-removing additive provided by the invention can effectively inhibit the growth of harmful bacteria, promote the growth of beneficial bacteria of the skin, maintain the balance of skin micro-ecology, create a good micro-ecological environment for the skin and further reduce the generation of skin diseases.

The acne-removing additive disclosed by the invention organically combines multiple acne-removing effects, has an all-around acne-removing effect, and has a good treatment effect on acne caused by various factors.

Drawings

FIG. 1 is a comparison of tester 1 before and after using the essence of example 3;

fig. 2 is a comparison of tester 2 before and after using the essence of example 3.

Detailed Description

The technical scheme of the invention is further explained by combining the examples.

The materials in the following examples are all commercial cosmetics or higher grade materials. For convenience of comparison, some of the raw materials were sourced as follows:

the Fuscoporia obliqua plant peptide, fructus Perillae extract, and folium Eucalypti Globueli extract are obtained from Guangzhou Chennuo Biotech limited; barley seed extract was purchased from fuzirui trade ltd, guangzhou;

inactivated lactobacillus and jerusalem artichoke root juice are purchased from Guangzhou repute gold trade company Limited.

The acne-removing additive can be compounded with auxiliary matrixes commonly used in skin care products to obtain corresponding skin care products. Such co-bases include, but are not limited to, surfactants, emollients, humectants, thickeners, chelating agents, deionized water, and the like.

The preparation of the skin care product is further exemplified by taking the essence as an example.

The composition of the essence is shown in table 1, and the dosage in the table is as follows by mass percent:

wherein, the lactobacillus in the embodiment 1-3 is prepared by mixing the components in a mass ratio of 1: 1 of lactobacillus casei and lactobacillus acidophilus.

The matrix comprises the following components: 0.05% of EDTA-2 sodium, 2% of pentanediol, 0.5% of hexanediol, 4% of butanediol, 0.3% of carbomer and 0.3% of arginine; the balance being deionized water.

The preparation process of the essence comprises the following steps:

1) putting deionized water into a pot, adding EDTA-2 sodium, pentanediol, hexanediol and carbomer pre-dispersed by butanediol, stirring and heating to 80-85 ℃, homogenizing to ensure that the material body is uniform, adding arginine dissolved by 1 time of deionized water, stirring and cooling;

2) cooling to below 40 deg.C, adding the acne removing additive components, stirring until the materials are completely dissolved, and filtering with 200 mesh filter cloth to obtain the above acne removing essence.

And (3) efficacy verification:

evaluation of acne removal effect

1. The tester: subjects aged 16-30 years with pox were divided into 11 groups of 15 people each. The subjects were volunteers enrolled in existing consumers of the company.

2. Test area: a face;

3. the use frequency is as follows: the medicine is taken in the morning and at night every day for 2 weeks;

4. evaluation method: and (5) questionnaire survey.

The test results are shown in Table 2 below

Group of	Obviously improve/human	General/human effects	No effect/person
				Example 1	8	7	0
Example 2	11	4	0
				Example 3	15	0	0
Comparative example 1	13	2	0
				Comparative example 2	0	7	8
Comparative example 3	1	7	7
				Comparative example 4	2	8	5
Comparative example 5	3	9	3
				Comparative example 6	2	9	4
Comparative example 7	2	8	5
				Comparative example 10	5	7	3

Note: comparative example 10 is a commercial acne removal product.

As can be seen from table 2:

1. example 1, in which the lowest amount of each component of the composition of the present invention was added, shows that the composition of the present invention has a superior effect on treating acne compared to the commercially available product of comparative example 9, indicating that the composition of the present invention is very effective in combination and can achieve a better effect even at a low dose.

2. Comparative examples 2 to 7 show that, when one component in the composition of the present invention is removed, the effect is far inferior to that of the composition of the present invention, as seen from the effect test results, the composition of the present invention has a synergistic acne removing effect, and the composition of the present invention has a very excellent acne removing effect through the mutual synergy between the components and the complete acne removing mechanism.

3. It can be seen from examples 1-3 that the anti-acne effect becomes better with the increase of the content of the components in the composition of the present invention, but the test results of comparative example 1 show that, outside the preferred range of the present invention, the better effect cannot be achieved by increasing the ratio of the components, but rather the skin burden is caused due to the high content of the components, and the effect is rather reduced compared to example 3, thus showing that the ratio of the components in the composition of the present invention is in a safe and effective range.

Fig. 1 is a graph showing a comparison between before and after the test person 1 uses the essence of example 3, and fig. 2 is a graph showing a comparison between before and after the test person 2 uses the essence of example 3. As can be seen from the comparative effect, the acne disappeared substantially and the skin of the test person was significantly changed 28 days after the essence was applied.

Second, safety test (human body skin patch experiment)

1. The number of tested persons: total 40, 20 men and 20 women, age between 18-30 years.

2. Health condition: the skin of the subject is healthy, the allergic history of the skin disease does not exist, and the voluntary selection standard of the subject is met.

3. The test method comprises the following steps: selecting a qualified spot tester, dropping about 0.05g of a test product into the spot tester in a closed spot patch experiment mode, externally attaching a special adhesive tape to the back of a test subject, 10 coating points are applied to each test subject, removing the test product after 24 hours, observing skin reactions after 0.5 hour, 24 hours and 48 hours respectively, grading according to skin reaction grading standards in cosmetic hygiene standards, calculating an average value, and recording results in a table 4.

4. The evaluation criteria are shown in Table 3

Table 3 standard table for testing spot-sticking on human skin

TABLE 4 Scoring results for skin Patch test

As can be seen from table 4, the ingredients of the composition of the present invention are very safe within the preferred ranges, very skin friendly and non-irritating, while the better acne removing products on the market still have different degrees of irritating response to the skin. However, increasing the amount of each component beyond the preferred ratio of the components of the present invention increases the skin irritation potential, and thus the range of ratios of the composition of the present invention is both effective and safe.

The foregoing is a more detailed description of the invention and is not to be taken in a limiting sense. It will be apparent to those skilled in the art that simple deductions or substitutions without departing from the spirit of the invention are within the scope of the invention.

Claims

1. An additive for removing acne comprises active ingredients including inactivated lactobacillus, yacon root juice, Fuscoporia Obliqua plant peptide, fructus Perillae extract, folium Eucalypti Globueli extract, semen Hordei vulgaris extract, sodium hyaluronate, and beta-dextran.

2. The acne treatment additive according to claim 1, wherein: the active ingredients of the composition comprise the following components in parts by mass: inactivating the lactobacillus: 0.01-1 part of yacon root juice: 0.1-10 parts of inonotus obliquus plant peptide: 0.1-2 parts of perilla seed extract, 0.1-5 parts of eucalyptus globulus leaf extract, 0.1-5 parts of barley seed extract: 0.1-5 parts of sodium hyaluronate: 0.1-1 part of beta-glucan: 0.1 to 0.6 portion.

3. The acne treatment additive according to claim 1, wherein: the active ingredients of the composition comprise the following components in parts by mass: inactivating the lactobacillus: 0.1-1 part of yacon root juice: 1-5 parts of inonotus obliquus plant peptide: 0.5-2 parts of perilla seed extract, 1-5 parts of eucalyptus globulus leaf extract, and barley seed extract: 1-5 parts of sodium hyaluronate: 0.1-1 part of beta-glucan: 0.1 to 0.6 portion.

4. The acne treatment additive according to any of claims 1 to 3, wherein: the lactobacillus consists of lactobacillus casei and lactobacillus acidophilus.

5. A skin care product characterized by: the acne-removing additive is added with the acne-removing additive as described in any one of claims 1-4.

6. A skin care product according to claim 5, characterized in that: the acne-removing additive comprises the following active ingredients in percentage by mass in a skin care product:

inactivating the lactobacillus: 0.1 to 1 percent

The yacon root juice: 1 to 5 percent

Fuscoporia obliqua plant peptide: 0.5 to 2 percent

1-5% of perilla seed extract

1-5% of eucalyptus globulus leaf extract

Barley seed extract: 1 to 5 percent

Sodium hyaluronate: 0.1 to 1 percent

Beta-glucan: 0.1 to 0.6 percent.

7. A skin care preparation according to claim 5 or 6, characterized in that: the skin care product is essence.

8. A skin care product according to claim 6, characterized in that: the essence comprises 0.05% of EDTA-2 sodium, 2% of pentanediol, 0.5% of hexanediol, 4% of butanediol, 0.3% of carbomer and 0.3% of arginine as a matrix.

9. The skin care product of claim 8, wherein: the essence comprises the following components in percentage by mass:

inactivating the lactobacillus: 1 percent of

The yacon root juice: 5 percent of

Fuscoporia obliqua plant peptide: 2 percent of

Perilla seed extract 5%

Eucalyptus globulus leaf extract 5%

Barley seed extract: 5 percent of

Sodium hyaluronate: 1 percent of

Beta-glucan: 0.6 percent

EDTA-2 sodium 0.05%

2 percent of pentanediol

0.5 percent of hexanediol

4 percent of butanediol

Carbomer 0.3%

Arginine 0.3%

The balance being deionized water.

10. A skin care product according to claim 9 wherein: the lactobacillus is prepared from the following components in a mass ratio of 1: 1 of lactobacillus casei and lactobacillus acidophilus.