CN113188979A - Full-automatic biochemical analyzer for tumor cell aging detection - Google Patents
Full-automatic biochemical analyzer for tumor cell aging detection Download PDFInfo
- Publication number
- CN113188979A CN113188979A CN202110468446.7A CN202110468446A CN113188979A CN 113188979 A CN113188979 A CN 113188979A CN 202110468446 A CN202110468446 A CN 202110468446A CN 113188979 A CN113188979 A CN 113188979A
- Authority
- CN
- China
- Prior art keywords
- plate
- fixedly connected
- fixing plate
- tumor cell
- full
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004881 tumor cell Anatomy 0.000 title claims abstract description 49
- 230000032677 cell aging Effects 0.000 title claims abstract description 20
- 238000001514 detection method Methods 0.000 title claims description 7
- 230000007246 mechanism Effects 0.000 claims abstract description 64
- 239000002699 waste material Substances 0.000 claims abstract description 21
- 238000009423 ventilation Methods 0.000 claims abstract description 18
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 10
- 210000004027 cell Anatomy 0.000 claims description 23
- 239000011521 glass Substances 0.000 claims description 10
- 230000032683 aging Effects 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 238000005192 partition Methods 0.000 claims description 4
- 230000009194 climbing Effects 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000000249 desinfective effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 5
- 206010028980 Neoplasm Diseases 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000008093 supporting effect Effects 0.000 description 4
- 230000001976 improved effect Effects 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- NCEXYHBECQHGNR-UHFFFAOYSA-N chembl421 Chemical compound C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 108010034791 Heterochromatin Proteins 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 101710188689 Small, acid-soluble spore protein 1 Proteins 0.000 description 1
- 101710188693 Small, acid-soluble spore protein 2 Proteins 0.000 description 1
- 101710166422 Small, acid-soluble spore protein A Proteins 0.000 description 1
- 101710166404 Small, acid-soluble spore protein C Proteins 0.000 description 1
- 101710174019 Small, acid-soluble spore protein C1 Proteins 0.000 description 1
- 101710174017 Small, acid-soluble spore protein C2 Proteins 0.000 description 1
- 101710174574 Small, acid-soluble spore protein gamma-type Proteins 0.000 description 1
- 102100036407 Thioredoxin Human genes 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000018732 detection of tumor cell Effects 0.000 description 1
- 231100000024 genotoxic Toxicity 0.000 description 1
- 230000001738 genotoxic effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000004458 heterochromatin Anatomy 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000036457 multidrug resistance Effects 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a full-automatic biochemical analyzer for detecting tumor cell aging, which comprises: the device comprises an analysis mechanism, a fixing mechanism, a jacking mechanism, a waste collecting mechanism, a storage mechanism, a ventilation mechanism and a disinfection mechanism; the analysis mechanism is used for detecting and analyzing tumor cells and comprises a first shell, a cover body is hinged to the top of the first shell, a first placing plate is arranged inside the first shell, and in the using process, the aged tumor cell slide can be automatically analyzed by only placing the aged tumor cell slide on the positioning plate and closing the cover body.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a full-automatic biochemical analyzer for tumor cell aging detection.
Background
Cell aging is a cellular process widely related to various human physiological and pathological processes such as aging occurrence, tumorigenesis and progression, stress, injury repair, and the like. Recent studies have shown that in tumor chemotherapy, some tumor cells often exhibit a cell-aging phenotype to cope with the effects of chemical drugs. Different from the apoptosis, the tumor cells are completely killed, the aged tumor cells still keep certain activity, and the arrest of cell division and proliferation also blocks the action of division, replication and damage expansion of the genotoxic drug. Long-term fate studies of aging cells have shown that cell aging is not a permanent arrest of cell growth, and cells may escape through aging and proliferate again within a certain period of time, thus causing tumor recurrence. In addition, the aged tumor cells have SASP phenotype which can secrete a plurality of inflammatory factors which can be continuously released into the damaged tumor microenvironment space, thereby inducing adjacent epithelial cells to cancerate and promoting the epithelial cells to acquire multidrug resistance, and finally leading to clinical treatment resistance.
Aged tumor cells have their characteristic cellular morphology and biochemical phenotype. The aged tumor cells have larger volume, the proportion of nucleus to nucleolus is increased, and the number of Golgi bodies and lysosomes is increased, so that the intracytoplasmic granules are obviously increased; aged cells may form associated heterochromatin colonies; beta-galactosidase enzymePositive active staining is shown; wherein, p16INK4AAnd pRb are also important marker molecules for tumor cell aging.
Therefore, if the proportion of the aged tumor cells in the tumor tissue can be effectively and accurately identified in the chemotherapy process of the tumor patient, the method is helpful for further controlling the occurrence of tumor drug resistance, so that the tumor therapy is developed towards an ideal direction.
Therefore, a full-automatic biochemical analyzer for detecting the aging of the tumor cells is provided.
Disclosure of Invention
The technical scheme of the invention is realized as follows:
a fully automated biochemical analyzer useful for the detection of tumor cell aging, comprising: the device comprises an analysis mechanism, a fixing mechanism, a jacking mechanism, a waste collecting mechanism, a storage mechanism, a ventilation mechanism and a disinfection mechanism;
wherein, the analysis mechanism is used for detecting and analyzing tumor cells and comprises a first shell, the top of the first shell is hinged with a cover body, a first placing plate is arranged in the first shell, the outer side of the first placing plate is fixedly connected with the inner side wall of the first shell, the lower surface of the cover body is provided with a fluorescence microscope, the interior of the cover body is fixedly provided with a cell image analyzer, the signal output end of the fluorescence microscope is connected with the signal input end of the cell image analyzer, the interior of the cover body is fixedly provided with a PLC controller, the signal output end of the cell image analyzer is connected with the signal input end of the PLC controller, the interior of the cover body is fixedly provided with a storage, the signal output end of the storage is connected with the signal input end of the PLC controller, and the upper surface of the cover body is fixedly connected with a display, the signal output end of the PLC is connected with the signal input end of the display;
wherein, the fixing mechanism is used for fixing the tumor cell slide glass to be detected, and the fixing mechanism comprises a first fixing plate which is fixedly connected with the upper surface of the first placing plate, the rear surface of the first fixing plate is fixedly connected with two first springs which are symmetrically arranged, one end of each first spring is fixedly connected with a second fixing plate, the rear surface of the second fixing plate is provided with a first electromagnet, one side of the second fixing plate is fixedly connected with a third fixing plate, the rear part of the first fixing plate is provided with a push plate, the rear surface of the push plate is fixedly connected with two second springs which are symmetrically arranged, one end of each second spring is fixedly connected with the front surface of the third fixing plate, the upper surface of the first placing plate is fixedly connected with a fourth fixing plate, the fourth fixing plate is positioned behind the first fixing plate, the two sides of the fourth fixing plate are fixedly connected with first plate bodies, the two first plate bodies are symmetrically arranged, the front surface of each first plate body is fixedly connected with a second electromagnet, the upper surface of the first placing plate is fixedly connected with a positioning plate, and the positioning plate is positioned between the fourth fixing plate and the first fixing plate;
wherein, climbing mechanism be used for with the lid carries out jack-up, just climbing mechanism includes two second plate bodies, two second plate body respectively fixed connection in the front surface and the rear surface of first casing, and two second plate body symmetry sets up, the first articulated seat of last fixed surface of second plate body is connected with, it has first even board to articulate on the first articulated seat, the top fixed mounting of first even board has electric putter, the equal fixedly connected with third plate body in front surface and the rear surface of lid, two the third plate body symmetry sets up, the lower fixed surface of third plate body is connected with the articulated seat of second, it has the second even board to articulate on the articulated seat of second, electric putter's piston rod with the bottom of second even board is articulated, the inside of first casing still includes garbage collection mechanism, deposits the mechanism, A ventilation mechanism and a disinfection mechanism.
Preferably, the waste collecting mechanism comprises a waste box, the waste box is placed inside the first shell, and a net cage is fixedly connected to the inner side wall of the waste box.
Preferably, the two fourth plate bodies are fixedly connected to the inside of the first shell, a sliding groove is formed in one side of each fourth plate body, a sliding block is fixedly connected to the inner side wall of the sliding groove, and one side of the sliding block is fixedly connected with the waste material box.
Preferably, the storage mechanism comprises a storage box, the storage box is fixedly connected to the inside of the first shell, and a partition plate is fixedly connected to the inner side wall of the storage box.
Preferably, a second placing plate is fixedly connected to the inner side wall of the storage box, and a supporting rod is fixedly connected to the upper surface of the second placing plate.
Preferably, the upper surface of the storage box is hinged with a cover plate, and the upper surface of the cover plate is fixedly connected with a handle.
Preferably, the ventilation mechanism comprises a second shell, the second shell is fixedly connected inside the first shell, first ventilation openings are formed in the second shell and the storage box, and second ventilation openings are uniformly formed in the upper surface of the second placing plate.
Preferably, a pipe body is communicated with one side of the first casing, and a fan is mounted on the inner side wall of the pipe body.
Preferably, the disinfection mechanism comprises an atomizer, the atomizer is fixedly connected with the bottom wall of the second shell, a water outlet end of the atomizer is communicated with a spray head, and the spray head is fixedly installed on the inner side wall of the storage box.
Preferably, the inner side wall of the storage box is fixedly connected with a third connecting plate, one side of the third connecting plate is fixedly connected with a UV lamp, and the inner side wall of the storage box is symmetrically and fixedly connected with two reflector plates.
Compared with the prior art, the invention has the advantages and positive effects that:
firstly, in the using process of the invention, the automatic analysis work can be carried out on the tumor cells only by placing the glass slide with the tumor cells on the positioning plate and closing the cover body, the operation steps are simple, and the tumor cells are analyzed to be in the closed environment, so that the interference of the external environment to the detection is avoided, the analysis result is more accurate, the accuracy of the analysis data is improved, and the better analysis on the drug resistance condition of the patient is facilitated.
Secondly, to the process of tumour cell analysis, it is automatic high, labour saving and time saving, improve medical personnel to the analytic efficiency of tumour cell.
And thirdly, the glass slide bearing the tumor cells is stored through the storage box, and the glass slide bearing the tumor cells has the functions of sterilization and disinfection, so that the functionality of the glass slide bearing the tumor cells is enriched, the using effect of the glass slide bearing the tumor cells is improved, and the analysis and the use of the tumor cells are facilitated.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a fully automatic biochemical analyzer for tumor cell aging detection according to an embodiment of the present invention;
fig. 2 is a schematic view of the internal structure of the first housing according to the embodiment of the present invention;
FIG. 3 is a schematic view of a structure on a cover of a cover according to an embodiment of the present invention;
FIG. 4 is a schematic side view of the structure of FIG. 3 according to an embodiment of the present invention;
fig. 5 is a schematic view of a coupling structure of a first placing plate and a first fixing plate according to an embodiment of the present invention;
fig. 6 is a schematic structural view of a fourth plate according to an embodiment of the present invention;
FIG. 7 is a schematic structural view of a storage compartment according to an embodiment of the present invention;
FIG. 8 is a schematic structural diagram of a cover according to an embodiment of the present invention;
FIG. 9 is a schematic view of the internal structure of the storage compartment and the second housing according to an embodiment of the present invention;
fig. 10 is a schematic view of the internal structure of the cover according to the embodiment of the present invention.
In the figure:
101. a first housing; 102. a cover body; 103. a first placing plate; 104. a fluorescence microscope; 105. a cell image analyzer; 106. a PLC controller; 107. a reservoir; 108. a display;
201. a first fixing plate; 202. a first spring; 203. a second fixing plate; 204. a first electromagnet; 205. a third fixing plate; 206. a second spring; 207. pushing the plate; 208. a fourth fixing plate; 209. a first plate body; 210. a second electromagnet; 211. positioning a plate;
301. a second plate body; 302. a first hinge mount; 303. a first connecting plate; 304. an electric push rod; 305. a third plate body; 306. a second hinge mount; 307. a second connecting plate;
401. a waste material box; 402. a net cage; 403. a fourth plate body; 404. a chute; 405. a slider;
501. a storage box; 502. a partition plate; 503. a second placing plate; 504. a support bar; 505. a cover plate; 506. a handle;
601. a second housing; 602. a first vent; 603. a second vent; 605. a pipe body; 606. a fan;
701. an atomizer; 702. a spray head; 703. a third connecting plate; 704. a UV lamp; 705. a reflector.
Detailed Description
In order that the above objects, features and advantages of the present invention can be more clearly understood, the present invention will be further described with reference to the accompanying drawings and examples. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
The invention is further described with reference to the following figures and specific examples.
Example 1
As shown in fig. 1 to 10, a fully automatic biochemical analyzer for tumor cell aging detection according to an embodiment of the present invention includes: the device comprises an analysis mechanism, a fixing mechanism, a jacking mechanism, a waste collecting mechanism, a storage mechanism, a ventilation mechanism and a disinfection mechanism;
wherein, the analysis mechanism is used for detecting and analyzing tumor cells, and the analysis mechanism comprises a first casing 101, a cover body 102 is hinged on the top of the first casing 101, a first placing plate 103 is arranged inside the first casing 101, the outer side of the first placing plate 103 is fixedly connected with the inner side wall of the first casing 101, a fluorescence microscope 104 is arranged on the lower surface of the cover body 102, a cell image analyzer 105 is fixedly arranged inside the cover body 102, the signal output end of the fluorescence microscope 104 is connected with the signal input end of the cell image analyzer 105, a PLC controller 106 is fixedly arranged inside the cover body 102, the signal output end of the cell image analyzer 105 is connected with the signal input end of the PLC controller 106, a storage 107 is fixedly arranged inside the cover body 102, the signal output end of the storage 107 is connected with the signal input end of the PLC controller 106, and a display 108 is fixedly connected on the upper surface of the cover body 102, the signal output end of the PLC 106 is connected with the signal input end of the display 108;
wherein, the fixing mechanism is used for fixing the tumor cell slide glass to be detected, and the fixing mechanism comprises a first fixing plate 201, the first fixing plate 201 is fixedly connected with the upper surface of the first placing plate 103, the rear surface of the first fixing plate 201 is fixedly connected with two first springs 202, the two first springs 202 are symmetrically arranged, one end of each first spring 202 is fixedly connected with a second fixing plate 203, the rear surface of the second fixing plate 203 is provided with a first electromagnet 204, one side of the second fixing plate 203 is fixedly connected with a third fixing plate 205, a push plate 207 is arranged behind the first fixing plate 201, the rear surface of the push plate 207 is fixedly connected with two second springs 206, the two second springs 206 are symmetrically arranged, one end of each second spring 206 is fixedly connected with the front surface of the third fixing plate 205, the upper surface of the first placing plate 103 is fixedly connected with a fourth fixing plate 208, the fourth fixing plate 208 is positioned behind the first fixing plate 201, the two sides of the fourth fixing plate 208 are fixedly connected with first plate bodies 209, the two first plate bodies 209 are symmetrically arranged, the front surface of the first plate body 209 is fixedly connected with a second electromagnet 210, the upper surface of the first placing plate 103 is fixedly connected with a positioning plate 211, and the positioning plate 211 is positioned between the fourth fixing plate 208 and the first fixing plate 201;
wherein the jacking mechanism is used for jacking up the cover body 102, and the jacking mechanism comprises two second plate bodies 301, the two second plate bodies 301 are respectively and fixedly connected with the front surface and the rear surface of the first shell 101, and two second plate bodies 301 symmetry sets up, the first articulated seat 302 of upper surface fixedly connected with of second plate body 301, it has first even board 303 to articulate on the first articulated seat 302, the top fixed mounting of first even board 303 has electric putter 304, the equal fixedly connected with third plate body 305 of front surface and the rear surface of lid 102, two third plate body 305 symmetries set up, the lower fixed surface of third plate body 305 is connected with the articulated seat 306 of second, it has even board 307 of second to articulate on the articulated seat 306 of second, electric putter 304's piston rod is articulated with the bottom of even board 307 of second, the inside of first casing 101 still includes garbage collection mechanism, deposit the mechanism, ventilation mechanism and disinfection mechanism.
By adopting the above technical scheme, the electric push rod 304 is started, the electric push rod 304 pushes the cover body 102, the cover body 102 is opened, the slide with tumor cells is placed on the positioning plate 211, the first electromagnet 204 and the second electromagnet 210 are started, the first electromagnet 204 is adsorbed on the second electromagnet 210, so as to drive the second fixing plate 203 to move, the second fixing plate 203 drives the third fixing plate 205 to move, the third fixing plate 205 drives the push plate 207 to move through the second spring 206, the slide on the positioning plate 211 is extruded by matching with the fourth fixing plate 208, so as to fix the slide, then the electric push rod 304 is controlled to close the cover body 102, the fluorescence microscope 104 and the cell image analyzer 105 are started, the fluorescence microscope 104 captures images of the cells on the slide, then the captured images are analyzed through the cell image analyzer 105, the storage 107 stores cell image data, the PLC controller 106 compares the cell image analyzer 105 with the data stored in the storage 107, so as to obtain the analysis result of the tumor cells.
Specifically, the garbage collection mechanism includes a garbage box 401, the garbage box 401 is placed in the first housing 101, and a net cage 402 is fixedly connected to the inner side wall of the garbage box 401.
Through adopting above-mentioned technical scheme, waste material box 401 is arranged in depositing the waste material that the analysis in-process produced, and box with a net 402 is deposited different waste materials in a classified way.
Specifically, deposit the mechanism and include storage tank 501, storage tank 501 fixed connection is in the inside of first casing 101, and the inside wall fixed connection of storage tank 501 has baffle 502.
By adopting the above technical scheme, the partition plate 502 plays a role in partitioning the space of the storage box 501.
Specifically, the ventilation mechanism includes a second housing 601, the second housing 601 is fixedly connected to the inside of the first housing 101, first ventilation openings 602 are formed in the second housing 601 and the inside of the storage box 501, and second ventilation openings 603 are uniformly formed in the upper surface of the second placement plate 503.
By adopting the technical scheme, the second ventilation opening 603 is convenient for drying the cleaned slide.
Specifically, disinfection mechanism includes atomizer 701, atomizer 701 fixed connection and the inside diapire of second casing 601, and atomizer 701's play water end intercommunication has shower nozzle 702, and shower nozzle 702 fixed mounting is in the inside wall of storage tank 501.
By adopting the technical scheme, alcohol is added into the atomizer 701, and the atomized alcohol is sprayed out through the spray head 702 to disinfect the glass slide.
Example 2
As shown in fig. 1-2 and 6, the present embodiment is different from embodiment 1 in that two fourth plate bodies 403 are fixedly connected to the inside of the first housing 101, a sliding groove 404 is formed in one side of the fourth plate body 403, a sliding block 405 is fixedly connected to the inner side wall of the sliding groove 404, and one side of the sliding block 405 is fixedly connected to the waste box 401.
Through adopting above-mentioned technical scheme, waste material box 401 passes through slider 405 and slides in spout 404, is convenient for carry out the dismouting to waste material box 401.
Example 3
As shown in fig. 1 to fig. 2 and fig. 9, the present embodiment is different from embodiment 2 in that a second placing plate 503 is fixedly connected to an inner side wall of the storage box 501, and a support rod 504 is fixedly connected to an upper surface of the second placing plate 503.
By adopting the technical scheme, the supporting rod 504 is used for supporting the slide and is convenient for taking the slide.
Specifically, the upper surface of the storage box 501 is hinged with a cover plate 505, and a handle 506 is fixedly connected to the upper surface of the cover plate 505.
By adopting the technical scheme, the articles in the storage box 501 can be isolated by closing the cover plate 505.
Example 4
As shown in fig. 1 to 3, the present embodiment is different from embodiment 3 in that a pipe 605 is communicated with one side of the first casing 101, and a fan 606 is mounted on an inner side wall of the pipe 605.
By adopting the above technical scheme, the fan 606 is used for accelerating the flow of gas in the storage box 501, thereby improving the drying speed of the cleaned slide.
Example 5
As shown in fig. 9, the present embodiment is different from embodiment 4 in that a third connecting plate 703 is fixedly connected to the inner sidewall of the storage box 501, a UV lamp 704 is fixedly connected to one side of the third connecting plate 703, and two reflective plates 705 are symmetrically and fixedly connected to the inner sidewall of the storage box 501.
By adopting the above technical scheme, the UV lamp 704 plays a role in sterilization and disinfection of the glass slide, and the reflector 705 improves the irradiation effect of the UV lamp 704.
For the convenience of understanding the technical solutions of the present invention, the following detailed description will be made on the working principle or the operation mode of the present invention in the practical process.
In practical application, the electric push rod 304 is started, the electric push rod 304 pushes the cover body 102, the cover body 102 is opened, a slide with tumor cells is placed on the positioning plate 211, the first electromagnet 204 and the second electromagnet 210 are started, the first electromagnet 204 is attached to the second electromagnet 210, so that the second fixing plate 203 is driven to move, the second fixing plate 203 drives the third fixing plate 205 to move, the third fixing plate 205 drives the push plate 207 to move through the second spring 206, the slide on the positioning plate 211 is squeezed in cooperation with the fourth fixing plate 208, so as to fix the slide, then the electric push rod 304 is controlled, the cover body 102 is closed, the fluorescence microscope 104 and the cell image analyzer 105 are started, the fluorescence microscope 104 captures images of the cells on the slide, then the captured images are analyzed through the cell image analyzer 105, the storage 107 stores cell image data, the cell image analyzer 105 is compared with data stored in the storage 107 through the PLC 106 to obtain an analysis result of aged tumor cells, the analysis data is displayed through the display 108 to achieve full-automatic analysis of the aged tumor cells, used slides are cleaned, the cleaned slides are placed on a supporting rod 504 of a second placing plate 503 in the storage box 501, a fan 606 is started, gas is discharged through the first ventilation opening 602 and the second ventilation opening 603, the flow of the gas in the storage box 501 is accelerated, the drying speed of the cleaned slides is improved, a UV lamp 704 is started to sterilize and disinfect the slides after drying, an atomizer 701 is started, atomized alcohol is sprayed out through the sprayer 702 and discharged through the second ventilation opening 603, and the atomized alcohol is contacted with the slides to sterilize the slides.
The present invention can be easily implemented by those skilled in the art from the above detailed description. It should be understood, however, that the intention is not to limit the invention to the particular embodiments described. On the basis of the disclosed embodiments, a person skilled in the art can combine different technical features at will, thereby implementing different technical solutions.
Claims (10)
1. A full-automatic biochemical analyzer for detecting tumor cell aging is characterized by comprising: analysis mechanism, fixed establishment and climbing mechanism.
2. The full-automatic biochemical analyzer for detecting tumor cell aging according to claim 1,
wherein the analysis mechanism is used for detecting and analyzing the aging of tumor cells and comprises a first shell (101), a cover body (102) is hinged to the top of the first shell (101), a first placing plate (103) is arranged in the first shell (101), the outer side of the first placing plate (103) is fixedly connected with the inner side wall of the first shell (101), a fluorescence microscope (104) is installed on the lower surface of the cover body (102), a cell image analyzer (105) is fixedly installed in the cover body (102), the signal output end of the fluorescence microscope (104) is connected with the signal input end of the cell image analyzer (105), a PLC (106) is fixedly installed in the cover body (102), and the signal output end of the cell image analyzer (105) is connected with the signal input end of the PLC (106), a storage device (107) is fixedly installed inside the cover body (102), a signal output end of the storage device (107) is connected with a signal input end of the PLC (106), a display (108) is fixedly connected to the upper surface of the cover body (102), and a signal output end of the PLC (106) is connected with a signal input end of the display (108);
wherein, the fixing mechanism is used for fixing the tumor cell slide glass to be detected, and the fixing mechanism comprises a first fixing plate (201), the first fixing plate (201) is fixedly connected with the upper surface of the first placing plate (103), the rear surface of the first fixing plate (201) is fixedly connected with two first springs (202), the two first springs (202) are symmetrically arranged, one end of the first spring (202) is fixedly connected with a second fixing plate (203), the rear surface of the second fixing plate (203) is provided with a first electromagnet (204), one side of the second fixing plate (203) is fixedly connected with a third fixing plate (205), the rear of the first fixing plate (201) is provided with a push plate (207), the rear surface of the push plate (207) is fixedly connected with two second springs (206), and the two second springs (206) are symmetrically arranged, one end of the second spring (206) is fixedly connected with the front surface of the third fixing plate (205), a fourth fixing plate (208) is fixedly connected to the upper surface of the first placing plate (103), the fourth fixing plate (208) is located behind the first fixing plate (201), first plate bodies (209) are fixedly connected to both sides of the fourth fixing plate (208), the two first plate bodies (209) are symmetrically arranged, a second electromagnet (210) is fixedly connected to the front surface of the first plate body (209), a positioning plate (211) is fixedly connected to the upper surface of the first placing plate (103), and the positioning plate (211) is located between the fourth fixing plate (208) and the first fixing plate (201);
wherein, the jacking mechanism is used for jacking the cover body (102), and the jacking mechanism comprises two second plate bodies (301), the two second plate bodies (301) are respectively and fixedly connected with the front surface and the rear surface of the first shell body (101), the two second plate bodies (301) are symmetrically arranged, the upper surface of the second plate body (301) is fixedly connected with a first hinged seat (302), the first hinged seat (302) is hinged with a first connecting plate (303), the top of the first connecting plate (303) is fixedly provided with an electric push rod (304), the front surface and the rear surface of the cover body (102) are respectively and fixedly connected with a third plate body (305), the two third plate bodies (305) are symmetrically arranged, the lower surface of the third plate body (305) is fixedly connected with a second hinged seat (306), and the second hinged seat (306) is hinged with a second connecting plate (307), a piston rod of the electric push rod (304) is hinged with the bottom of the second connecting plate (307), and the first shell (101) further comprises a waste collecting mechanism, a storing mechanism, a ventilating mechanism and a disinfecting mechanism; the waste material collecting mechanism comprises a waste material box (401), the waste material box (401) is placed inside the first shell (101), and a net box (402) is fixedly connected to the inner side wall of the waste material box (401).
3. The full-automatic biochemical analyzer for detecting tumor cell aging according to claim 2, wherein two fourth plate bodies (403) are fixedly connected to the inside of the first housing (101), a sliding groove (404) is formed in one side of each fourth plate body (403), a sliding block (405) is fixedly connected to the inner side wall of each sliding groove (404), and one side of each sliding block (405) is fixedly connected to the waste material box (401).
4. The full-automatic biochemical analyzer for detecting tumor cell aging according to claim 2, wherein the storage mechanism comprises a storage box (501), the storage box (501) is fixedly connected to the inside of the first housing (101), and a partition (502) is fixedly connected to the inner side wall of the storage box (501).
5. The full-automatic biochemical analyzer for detecting tumor cell aging according to claim 4, wherein a second placing plate (503) is fixedly connected to the inner side wall of the storage box (501), and a support rod (504) is fixedly connected to the upper surface of the second placing plate (503).
6. The full-automatic biochemical analyzer for detecting tumor cell aging according to claim 5, wherein the upper surface of the storage box (501) is hinged with a cover plate (505), and the upper surface of the cover plate (505) is fixedly connected with a handle (506).
7. The full-automatic biochemical analyzer for detecting tumor cell aging according to claim 5, wherein the ventilation mechanism comprises a second housing (601), the second housing (601) is fixedly connected to the inside of the first housing (101), the second housing (601) and the storage box (501) are both provided with a first ventilation opening (602), and the upper surface of the second placement plate (503) is uniformly provided with a second ventilation opening (603).
8. The full-automatic biochemical analyzer for detecting tumor cell aging according to claim 7, wherein a tube (605) is connected to one side of the first housing (101), and a fan (606) is installed on the inner side wall of the tube (605).
9. The full-automatic biochemical analyzer for tumor cell aging detection according to claim 7, wherein the disinfection mechanism comprises an atomizer (701), the atomizer (701) is fixedly connected to the inner bottom wall of the second housing (601), a spray head (702) is communicated with the water outlet end of the atomizer (701), and the spray head (702) is fixedly installed on the inner side wall of the storage box (501).
10. The full-automatic biochemical analyzer for detecting tumor cell aging according to claim 9, wherein a third connecting plate (703) is fixedly connected to the inner sidewall of the storage box (501), a UV lamp (704) is fixedly connected to one side of the third connecting plate (703), and two reflective plates (705) are symmetrically and fixedly connected to the inner sidewall of the storage box (501).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110468446.7A CN113188979B (en) | 2021-04-28 | 2021-04-28 | Full-automatic biochemical analyzer for tumor cell aging detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110468446.7A CN113188979B (en) | 2021-04-28 | 2021-04-28 | Full-automatic biochemical analyzer for tumor cell aging detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113188979A true CN113188979A (en) | 2021-07-30 |
| CN113188979B CN113188979B (en) | 2022-03-18 |
Family
ID=76980064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110468446.7A Active CN113188979B (en) | 2021-04-28 | 2021-04-28 | Full-automatic biochemical analyzer for tumor cell aging detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113188979B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN208766050U (en) * | 2018-09-05 | 2019-04-19 | 四川鼎鑫玻璃制品有限公司 | A kind of novel tempering glass clamp holds device |
| CN109825427A (en) * | 2019-02-25 | 2019-05-31 | 广州牛顿光学研究院有限公司 | A kind of full-automatic cell activity analysis system |
| CN210378340U (en) * | 2019-08-30 | 2020-04-21 | 海南中旗网络科技有限公司 | Party building information display device with content convenient to replace |
| CN212040742U (en) * | 2019-12-19 | 2020-12-01 | 林昭元 | Impact crusher for mining |
| CN212568218U (en) * | 2020-08-18 | 2021-02-19 | 深圳市盛达思科技有限公司 | Cell-phone liquid crystal display glass processing is with resistance to compression detection device |
-
2021
- 2021-04-28 CN CN202110468446.7A patent/CN113188979B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN208766050U (en) * | 2018-09-05 | 2019-04-19 | 四川鼎鑫玻璃制品有限公司 | A kind of novel tempering glass clamp holds device |
| CN109825427A (en) * | 2019-02-25 | 2019-05-31 | 广州牛顿光学研究院有限公司 | A kind of full-automatic cell activity analysis system |
| CN210378340U (en) * | 2019-08-30 | 2020-04-21 | 海南中旗网络科技有限公司 | Party building information display device with content convenient to replace |
| CN212040742U (en) * | 2019-12-19 | 2020-12-01 | 林昭元 | Impact crusher for mining |
| CN212568218U (en) * | 2020-08-18 | 2021-02-19 | 深圳市盛达思科技有限公司 | Cell-phone liquid crystal display glass processing is with resistance to compression detection device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113188979B (en) | 2022-03-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN212487858U (en) | Laboratory mouse feeding box | |
| CN113188979B (en) | Full-automatic biochemical analyzer for tumor cell aging detection | |
| CN208259777U (en) | A kind of obstetrics and gynecology department medicine-feeding sterilization of instruments cleaning device | |
| CN210235686U (en) | Be used for sample case for bio-medical treatment | |
| CN111701054A (en) | Medical emergency department instrument disinfection device and using method thereof | |
| CN108043487B (en) | Multifunctional experimental device for biological research | |
| CN210455553U (en) | Medical science inspection sample board deposits case | |
| CN211027376U (en) | Pipette washs sterilization apparatus | |
| CN210434542U (en) | Clinical laboratory uses anti-pollution storage device | |
| CN216456152U (en) | Portable community nursing degassing unit | |
| CN211586640U (en) | Chemical analysis instrument deposits and uses biological safety cabinet | |
| CN206314820U (en) | A kind of medical supplies placement cabinet | |
| CN214285990U (en) | Silica gel product sterilizing and disinfecting device | |
| CN213821837U (en) | A strorage device for department of stomatology apparatus | |
| CN218220654U (en) | Sterilization device for stem cell transplantation | |
| CN210700208U (en) | Fixing device is deposited to laboratory's instrument | |
| CN214430926U (en) | Mouse frame for antibody research and development | |
| CN218173036U (en) | Avoid glass slide strorage device for microbiological experiments of pollution | |
| CN214974081U (en) | Novel biological safety cabinet | |
| CN214908127U (en) | Medical instrument disinfection is deposited and is taken device | |
| CN209848913U (en) | Biological safety cabinet with excellent safety performance | |
| CN113575444B (en) | Intelligent forced swimming device for big and small mice | |
| CN213506950U (en) | Microbial culture device for biological experiment | |
| CN218529377U (en) | Disinfection device | |
| CN215139982U (en) | Novel experiment dyeing cabinet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |