CN113142429B - Qi and blood tonifying beverage composition and preparation method thereof - Google Patents
Qi and blood tonifying beverage composition and preparation method thereof Download PDFInfo
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- CN113142429B CN113142429B CN202110295343.5A CN202110295343A CN113142429B CN 113142429 B CN113142429 B CN 113142429B CN 202110295343 A CN202110295343 A CN 202110295343A CN 113142429 B CN113142429 B CN 113142429B
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention provides a qi and blood replenishing beverage composition which is characterized by being prepared from the following raw materials in parts by weight: 20-60 parts of peanut skin; 2-55 parts of cranberry; 2-50 parts of rose; 0.5-30 parts of angelica; 1-30 parts of perilla leaves; 1-30 parts of ginseng; and 0.5-20 parts of galangal. All raw materials of the qi and blood tonifying beverage composition are medicinal and edible substances or food, so that the composition is high in safety and has the effects of tonifying qi, enriching blood and promoting qi circulation to remove qi stagnation. The perilla leaves are used as the medicine for promoting the circulation of qi, so that the qi can be supplemented without stagnation, and a better qi and blood supplementing effect can be realized.
Description
Technical Field
The invention belongs to the field of processing of functional foods, and particularly relates to a qi and blood tonifying beverage composition and a preparation method thereof.
Background
In the cloud of the Huangdi's Canon of Huang Di Nei Jing, the theory of blood as the mother of qi and qi as the commander of blood in TCM shows that qi and blood depend on each other and accompany each other, so as to jointly maintain and promote life activities. The theory of blood syndrome, theory of yin yang, water, fire, blood and qi: the "qi-guarding person means blood", and the book Ling Shu & Ying sanitary meeting says: the "nutrient qi moving in the blood vessels" refers to the qi in blood vessels that can move blood, and the qi is not attached to the blood because the blood can carry the gas, so the qi will not disperse and get rid of the blood. Qi is attached to blood, and blood carries qi and continuously provides food essence for the functional activities of qi to supplement nutrition, so that exuberance of qi causes exuberance of blood, deficiency of blood causes qi deficiency, and blood degassing is also lost, which is also known as qi deficiency in blood diseases. Therefore, patients with blood deficiency are often accompanied by qi deficiency such as shortness of breath, fatigue, laziness to speak, etc.
Qi deficiency refers to the condition of weakness of the zang-fu organs and tissues, manifested as shortness of breath, fatigue, mental fatigue, and pulse deficiency. It is usually caused by weakness due to chronic diseases, fatigue, and physical weakness due to old age. The specific clinical manifestations include poor disease resistance, aversion to cold, cold limbs, spontaneous perspiration, dizziness, tinnitus, listlessness, fatigue, palpitation, shortness of breath and hypoevolutism.
Blood deficiency refers to the weak condition of the face, palpebral margin, lips, pale tongue and thready pulse due to blood deficiency, malnutrition of the zang-fu organs, meridians and tissues. It is usually caused by excessive blood loss, insufficient blood production, or excessive anxiety, and dark consumption of yin blood. The clinical manifestations include lusterless sallow complexion, dry skin, dry hair, dry nails, blurred vision, numbness of hands and feet, insomnia, dreaminess, amnesia, palpitation, absentmindedness, etc.
Because qi and blood have a close relationship of interdependence, breeding and mutual interaction, qi and blood often affect each other when pathological changes occur. Qi-blood deficiency refers to the condition of both qi deficiency and blood deficiency.
With the change of life style and the explosion of social pressure, modern people have a large number of sub-healthy populations presenting symptoms of qi and blood deficiency among many young and middle-aged people. However, the qi and blood deficiency of the people is not caused by the passive qi and blood generation caused by insufficient nutrient substances, but caused by insufficient transportation and transformation of five cereals due to improper life style, and the normal transportation and transformation of qi and blood in the body are influenced by adverse factors such as long-term air-conditioning environment, sedentary and restlessness and the like. Therefore, the traditional Chinese medicine has the effects of tonifying qi and enriching blood, and is assisted with qi stagnation to promote the circulation of qi and blood and increase the nourishing and warming capacity of blood, so that the circulation and transformation of qi and blood of a human body are adjusted to be normal, five cereals can fully nourish four limbs, and the human body tends to be mild. Aiming at people with qi deficiency and blood stasis constitution, relatively mild and medicinal and edible materials are selected, and the food therapy effect is realized through a reasonable formula. Therefore, the king sun Simiao in the cloud of thousand gold essences: the whole life is not enough for those who do not know proper diet. If you are ill, you take a life-saving diet to treat it. If the diet therapy fails to cure, the medicine is activated. "
Disclosure of Invention
The invention aims to provide a qi and blood replenishing beverage composition and a preparation method thereof.
Specifically, the present invention relates to the following aspects:
1. a qi and blood replenishing beverage composition, wherein the composition comprises peanut skin extract, rose extract, angelica extract, perilla extract, ginseng extract, galangal extract, and cranberry juice.
2. The composition according to item 1, wherein the composition further comprises one or more of hyaluronic acid, thickened pulp of red dates, and taste modifiers.
3. The drink composition for tonifying qi and blood is characterized by being prepared from the following raw materials in parts by weight:
the peanut skin accounts for 20-60 parts, preferably 20-50 parts, and more preferably 20-35 parts;
2-55 parts of cranberry, preferably 5-40 parts of cranberry, and more preferably 5-30 parts of cranberry;
2-50 parts of rose, preferably 5-20 parts, more preferably 5-18 parts;
when the amount is 0.5-30 parts, preferably 5-20 parts, more preferably 5-18 parts;
1-30 parts of perilla leaf, preferably 3-18 parts, more preferably 5-15 parts;
1-30 parts of ginseng, preferably 5-16 parts of ginseng, and more preferably 5-15 parts of ginseng;
and galangal in 0.5-20 weight portions, preferably 2-15 weight portions, and especially 3-12 weight portions.
4. The qi and blood replenishing beverage composition according to item 3, wherein the raw materials of the composition further comprise one or more than two of hyaluronic acid, thickened red jujube pulp and a taste modifier.
5. The qi and blood replenishing beverage composition according to the item 3, wherein the preparation method of the composition comprises the following steps:
extracting radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum to obtain a first extract;
extracting peanut red skin, rose and perilla leaf to obtain a second extract;
preparing concentrated cranberry juice;
preparing a qi and blood replenishing drink composition from the first extract, the second extract and the concentrated cranberry juice.
6. The qi and blood replenishing beverage composition according to item 5, wherein the step of extracting angelica, ginseng and galangal to obtain the first extract comprises:
weighing radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum, adding water, decocting for 0.5-2h, and filtering to obtain a first extract, wherein the weight of the added water is 10-30 times of the total weight of radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum.
7. The qi and blood replenishing beverage composition according to item 5, wherein the step of extracting the peanut red skin, the rose and the perilla leaf to obtain the second extract comprises:
weighing peanut skin, rose and perilla leaf, adding water, soaking for 0.5-2h, and filtering to obtain a second extract, wherein the mass of the added water is 10-30 times of the total mass of the peanut skin, rose and perilla leaf.
8. The qi and blood replenishing beverage composition according to claim 5, wherein the step of preparing the concentrated cranberry juice comprises:
weighing fresh cranberry fruits, adding water 2-4 times of the fresh cranberry fruits by weight, and cold-pressing to obtain cranberry juice;
adding juice clarifier into cranberry juice, clarifying, boiling at high temperature, cooling, centrifuging to obtain supernatant, and concentrating by nanofiltration 6-15 times to obtain concentrated cranberry juice.
9. The qi and blood replenishing beverage composition according to claim 5, wherein the step of preparing the qi and blood replenishing beverage composition from the first extract, the second extract and the concentrated cranberry juice comprises:
and uniformly mixing the first extract and the second extract, concentrating, refining, adding the concentrated cranberry juice, and adding water to dilute by 7-15 times to obtain the qi and blood replenishing beverage composition.
10. The qi and blood replenishing beverage composition according to item 9, wherein one or more of hyaluronic acid, red date puree, and taste modifier are further added before dilution with water in the step of preparing the qi and blood replenishing beverage composition from the first extract, the second extract, and the concentrated cranberry juice.
11. The qi and blood replenishing beverage composition according to claim 9, wherein the refining is a precipitation treatment using ethanol, and the concentration of the selected ethanol is 40-60%, preferably 45-55%.
12. The preparation method of the drink composition for tonifying qi and blood is characterized by comprising the following steps:
extracting radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum to obtain a first extract;
extracting peanut red skin, rose and perilla leaf to obtain a second extract;
preparing a concentrated cranberry juice;
preparing the qi and blood replenishing beverage composition from the first extract, the second extract and the concentrated cranberry juice.
13. The production method according to item 12, wherein the reaction mixture is, in parts by weight,
the peanut skin accounts for 20-60 parts, preferably 20-50 parts, and more preferably 20-35 parts;
2-55 parts of cranberry, preferably 5-40 parts of cranberry, and more preferably 5-30 parts of cranberry;
the rose is 2-50 parts, preferably 5-20 parts, and more preferably 5-18 parts;
the angelica is 0.5-30 parts, preferably 5-20 parts, and more preferably 5-18 parts;
1-30 parts of perilla leaf, preferably 3-18 parts, more preferably 5-15 parts;
1-30 parts of ginseng, preferably 5-16 parts, and more preferably 5-15 parts;
and 0.5-20 parts of galangal, preferably 2-15 parts, and more preferably 3-12 parts.
14. The qi and blood replenishing beverage composition according to claim 12, wherein the step of extracting angelica sinensis, ginseng and galangal to obtain the first extract comprises:
weighing radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum, adding water, decocting for 0.5-2h, and filtering to obtain a first extract, wherein the weight of the added water is 10-30 times of the total weight of radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum.
15. The qi and blood replenishing beverage composition according to claim 12, wherein the step of extracting the peanut red skin, the rose and the perilla leaf to obtain the second extract comprises:
weighing peanut skin, rose and perilla leaf, adding water, soaking for 0.5-2h, and filtering to obtain a second extract, wherein the mass of the added water is 10-30 times of the total mass of the peanut skin, the rose and the perilla leaf.
16. The qi and blood replenishing beverage composition according to claim 12, wherein the step of preparing the concentrated cranberry juice comprises:
weighing fresh cranberry fruits, adding water 2-4 times of the fresh cranberry fruits by weight, and cold-pressing to obtain cranberry juice;
adding juice clarifier into cranberry juice, boiling at high temperature, cooling, centrifuging to obtain supernatant, and concentrating by nanofiltration 6-15 times to obtain concentrated cranberry juice.
17. The qi and blood replenishing beverage composition according to claim 12, wherein the step of preparing the qi and blood replenishing beverage composition from the first extract, the second extract and the concentrated cranberry juice comprises:
and uniformly mixing the first extract and the second extract, concentrating, refining, adding the concentrated cranberry juice, and adding water to dilute by 7-15 times to obtain the qi and blood replenishing beverage composition.
18. The qi and blood replenishing beverage composition according to item 17, wherein one or more of hyaluronic acid, red date puree, and taste modifier are further added before dilution with water in the step of preparing the qi and blood replenishing beverage composition from the first extract, the second extract, and the concentrated cranberry juice.
19. The qi and blood replenishing beverage composition according to claim 17, wherein the refining is a precipitation treatment using ethanol, and the concentration of the selected ethanol is 40-60%, preferably 45-55%.
All raw materials of the composition are medicinal and edible substances or food, so the composition has high safety and has the effects of tonifying qi, enriching blood and promoting qi circulation to remove qi stagnation. Compared with the existing healthy product composition for tonifying qi and blood, the composition has remarkable advantages in the aspect of the formula principle, mainly supplements qi and blood (angelica sinensis, ginseng tonifies primordial qi and peanut skin nourishes blood), is supplemented with qi-transforming stagnation and warming substances (rose flower promotes qi and removes stasis, perilla leaf promotes qi and removes food retention and stagnation, galangal warms middle-jiao to dispel cold), and is added with cranberry capable of improving endocrine function, so that the effects of tonifying qi and blood are achieved together. The raw materials selected by the formula are medicinal and edible substances, so that the tonifying is not drastic, and the tonifying is not stagnated, and the formula mainly has the effects of improving vital qi of a human body, promoting transportation, transformation and absorption of food essence of the human body, and regulating the functions of the human body to reach a mild and balanced state, so that qi and blood are harmonized, and the sub-health state of qi and blood deficiency is improved.
Detailed Description
The present invention is further illustrated by the following examples, which are intended to be purely exemplary of the invention and are not intended to be limiting.
Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. Although methods and materials similar or equivalent to those described herein can be used in experimental or practical applications, the materials and methods are described below. In case of conflict, the present specification, including definitions, will control, and the materials, methods, and examples are illustrative only and not intended to be limiting. The present invention is further illustrated by the following examples, which are not intended to limit the scope of the invention.
The invention provides a qi and blood replenishing beverage composition which comprises a peanut skin extract, a rose extract, an angelica extract, a perilla extract, a ginseng extract, a galangal extract and cranberry juice.
The peanut red skin, namely the seed coat of the peanut, is named as peanut red skin because the seed coat of most peanut varieties is red, and can inhibit the dissolution of fibrin, increase the content of platelets, improve the quality of the platelets, improve the defect of blood coagulation factors, strengthen the contraction function of capillary vessels and promote the hemopoiesis function of bone marrow.
In a specific embodiment of the invention, the peanut red skin is derived from red-skin small peanuts, and red outer skins of the peanuts are obtained by shelling after frying.
Cranberries, also known as cranberries, are the evergreen, dwarf shrub plants of the genus Vaccinium (Vaccinium macrocarpon) of the family Ericaceae, which collectively look like a crane, with flowers like the head and mouth of the crane, and are also known as "cranberries". The fruit of the cherry fruiter is an oval berry with the length of 2-5 cm, turns dark red from white, and has a heavy sour and slightly sweet taste when being eaten. Mainly grown in the acid peat soil of the cool zone of the northern hemisphere, and is called traditional three big fruits in North America together with Kangkote grapes and blueberries. The cranberry has the characteristics of high moisture, low calorie, high fiber and multiple minerals, so that the cranberry is favored by people. Cranberries are rich in not only vitamin C but also phytochemicals, including anthocyanins, proanthocyanidins, ellagic acid, and the like, and are said to be super antioxidants.
Flos Rosae Rugosae has effects of regulating qi-flowing, resolving stagnation, regulating blood circulation and removing blood stasis, and can be used for treating liver and stomach qi pain, new and chronic arthralgia due to wind, hematemesis and hemoptysis, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling, etc. The Chinese herbal medicine Zhengyi says that the medicine has the characteristics of the highest fragrance, clearness without turbidity, harmony without fierce, liver softening and stomach awakening, qi tonifying and blood circulation promoting, suffocation without the disadvantages of acridity, rigidity and dryness, and the best effect and the most excellent taste among qi breaking and pushing, and all the fragrant products have no match. The rose is not only pharmaceutically acceptable, but also is a superior food material for preserving health and cooking medicinal meals, can cook delicious dishes such as rose glass meat, rose bean curd, rose salad, rose porridge and the like, can also be prepared into rose jam, rose massecuite, crystal sugar rose, rose vinegar and the like, can be used for soaking water to replace tea for drinking, can be added with sugar or honey, and has the effects of regulating qi and blood, soothing liver and dispelling melancholy, reducing fat and losing weight, moistening skin and beautifying and the like. It is especially effective in treating dysmenorrhea and menoxenia.
In a specific embodiment of the present invention, the source of the rose is edible rose, preferably golden rose, rose with pink color, bitter rose, rose with pink color, and more preferably rose with pink color and rose with pink color.
Chinese angelica root, named as Chinese medicine. Is dried root of Angelica sinensis (Oliv.) Diels) belonging to family Umbelliferae. The major production of the southeast part of Gansu province is large in yield and good in quality due to Min county, and the second generation is cultivation in Yunnan province, Sichuan province, Shaanxi province, Hubei province and the like. Has the functions of enriching blood, promoting blood circulation, regulating menstruation, relieving pain, moistening intestine and relaxing bowels. It is commonly indicated for blood deficiency and sallow complexion, vertigo and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, deficiency cold and abdominal pain, rheumatic arthralgia, traumatic injury, carbuncle, deep-rooted carbuncle, pyocutaneous disease, constipation due to intestinal dryness. The wine angelica sinensis can activate blood and dredge channels. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
The folium Perillae is dried leaf (or with twig) of Perilla frutescens (L.) Britt of Labiatae. Collected in summer when branches and leaves are luxuriant, removed of impurities and dried in the sun. The main functional indications of the perilla leaves comprise: relieve exterior syndrome, dispel cold, move qi and harmonize stomach. Can be used for treating wind-cold type common cold, cough, emesis, vomiting of pregnancy, and fish and crab poisoning. Perilla leaf has the effects of dispelling exterior cold and inducing sweat, and can be used for treating wind-cold exterior syndrome with symptoms of aversion to cold, fever and anhidrosis, and is often combined with rhizoma Zingiberis recens; for exterior syndrome accompanied by qi stagnation, it is combined with Xiang Fu and Chen Pi, etc. Perilla leaf is used for spleen and stomach qi stagnation, chest distress and nausea, and can be applied regardless of exterior symptoms, and is usually combined with Huoxiang for clinical application. In addition, it can move qi and prevent abortion, and is often combined with Sha ren and Chen Pi to treat vomiting of pregnancy and threatened abortion. Perilla is pungent and warm, and can relieve fish and crab toxin, and can be decocted alone or combined with rhizoma Zingiberis recens for oral administration after neutralizing fish and crab toxin.
In one embodiment of the present invention, the base source of the Perilla leaf is Perilla frutescens (L.) britt, preferably a purplish variety, more preferably a purplish-surfaced variety with sufficient aroma.
Ginseng, a perennial herb, prefers cool and humid climate, is called "Baicao king" by people, is one of the three treasures of northeast China (ginseng, marten skin, hairy antler) which are evergreen and is a famous and precious medicinal material known by all people of China and abroad. The plants grow in a broad mixed forest or a mixed forest with small day-night temperature difference and a gentle slope in mountainous regions of 500-1100 m or slope lands. Ancient Ginseng is called rhizoma Polygonati, herba Hyperici Japonici, and Shencao. The root is fat and thick, and shaped like a spindle, which is often branched and looks like the head, hands, feet and limbs of a person, so the ginseng is called ginseng. The succulent root of ginseng is a well-known tonic, is suitable for regulating blood pressure, recovering heart function, neurasthenia and asthenia, and also has expectorant, stomach invigorating, diuretic and exciting effects. Ginseng radix or its extract has effects of protecting and stimulating hemopoietic function of bone marrow, and increasing erythrocyte count, leukocyte count and hemoglobin amount of normal and anemia animals. It can also increase the number of red blood cells, hemoglobin and platelets in anemia patients. The effect of ginseng on increasing the number of peripheral blood cells is more pronounced when peripheral blood cells are reduced or bone marrow is inhibited. Ginseng stimulates hematopoietic function by increasing synthesis of bone marrow DNA, RNA, proteins and lipids, promoting mitosis of bone marrow cells.
Alpinia officinarum, also known as galangal and lesser galangal. Is dried rhizome of Alpinia officinarum Hance of Zingiberaceae. Collected in late summer and early autumn, the fibrous root and the residual scale are removed, cleaned, cut into segments and dried in the sun. Galangal is pungent and hot in nature. Enter spleen and stomach meridians. Has effects in dispelling cold, relieving pain, warming middle warmer, and relieving vomit. Galangal is commonly used in the clinic for abdominal cold pain, and can be used with gan Jiang and other herbs; for gastric cavity pain due to congealing cold and qi stagnation, it is often combined with Xiang Fu; gao Liang Jiang can also be used for clearing water for stomach cold, adverse rising of qi and vomiting, and can be used with Sheng Jiang and ban Xia, etc., or decocted with Zi Zao for oral administration. Rhizoma Alpiniae Officinarum has antibacterial effect, and can inhibit hemolytic streptococcus, Diptheria bacillus, Diplococcus pneumoniae, and Salmonella typhi. In addition, galangal has the function of benefiting gallbladder and a certain antidiarrheal effect. Rhizoma Alpiniae Officinarum can also delay thrombosis and inhibit platelet aggregation, and can be used for treating cardiovascular disease and cerebrovascular disease.
Furthermore, the composition of the invention can also comprise one or more than two of hyaluronic acid, red date thick paste and taste modifier.
The invention also provides a qi and blood replenishing beverage composition, which is characterized by being prepared from the following raw materials in parts by weight:
20-60 parts of peanut skin, preferably 20-50 parts, more preferably 20-35 parts;
2-55 parts of cranberry, preferably 5-40 parts of cranberry, and more preferably 5-30 parts of cranberry;
2-50 parts of rose, preferably 5-20 parts, more preferably 5-18 parts;
when the amount is 0.5-30 parts, preferably 5-20 parts, more preferably 5-18 parts;
1-30 parts of perilla leaf, preferably 3-18 parts, more preferably 5-15 parts;
1-30 parts of ginseng, preferably 5-16 parts of ginseng, and more preferably 5-15 parts of ginseng;
and galangal in an amount of 0.5-20 parts, preferably 2-15 parts, more preferably 3-12 parts.
Wherein the parts by weight of the raw materials refer to the mass of the added raw materials and to the mass ratio of the raw materials. For example, in the raw materials of the composition, the weight ratio of the peanut skin to the cranberry is 20 parts, the cranberry is 2 parts, the rose is 2 parts, the angelica is 0.5 part, the perilla leaf is 1 part, the ginseng is 1 part, and the galangal is 0.5 part, namely the raw materials are 20:2:2:0.5:1:1: 0.5.
Furthermore, the raw materials of the composition can also comprise one or more than two of hyaluronic acid, red jujube thick paste and a taste regulator. The preparation method of the composition comprises the following steps:
extracting radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum to obtain a first extract;
extracting peanut red skin, rose and perilla leaf to obtain a second extract;
preparing a concentrated cranberry juice;
preparing the qi and blood replenishing beverage composition from the first extract, the second extract and the concentrated cranberry juice.
In a specific embodiment, the step 1 of extracting angelica, ginseng and galangal to obtain the first extract comprises:
weighing radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum, adding water, decocting for 0.5-2 hr, preferably 0.5-1.5 hr, more preferably 45min-1 hr, and filtering to obtain a first extract, wherein the weight of the added water is 10-30 times of the total weight of radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum.
In one embodiment, the step of extracting the peanut red skin, rose and perilla leaves to obtain the second extract comprises:
weighing peanut skin, rose and perilla leaf, adding water, soaking for 0.5-2h, and filtering to obtain a second extract, wherein the mass of the added water is 10-30 times of the total mass of the peanut skin, rose and perilla leaf. The extraction process of the peanut skin, the rose and the perilla leaf comprises the following steps: adding 10-30 times of water, soaking at 50-100 deg.C for 0.5-2 hr, preferably 60-80 deg.C for 0.5-1.5 hr, more preferably 55-70 deg.C for 0.5-1 hr.
In a particular embodiment, step 3 of preparing the concentrated cranberry juice comprises:
weighing fresh cranberry, adding water 2-4 times of the fresh cranberry, and cold pressing to obtain cranberry juice; adding juice clarifier into cranberry juice, clarifying, boiling at high temperature, cooling, centrifuging to obtain supernatant, and concentrating by nanofiltration 6-15 times to obtain concentrated cranberry juice.
In a specific embodiment, the step of preparing the qi and blood replenishing beverage composition from the first extract, the second extract and the concentrated cranberry juice comprises:
and uniformly mixing, concentrating and refining the first extract and the second extract, adding the concentrated cranberry juice, and adding water to dilute by 7-15 times to obtain the qi and blood tonifying beverage composition. One or more of hyaluronic acid, thickened pulp of red dates and taste modifiers can also be added to the mixture of the extract and the concentrated cranberry juice before dilution with water.
In a specific embodiment, said refining in the step of preparing the qi and blood replenishing drink composition from said first extract, said second extract and said concentrated cranberry juice is a precipitation treatment with ethanol, the concentration of the selected ethanol being 40-60%, preferably 45-55%.
Further, the preparation method also comprises the steps of sterilizing, filling and packaging the obtained qi and blood replenishing drink composition to obtain a finished product.
All raw materials of the qi and blood replenishing beverage composition are medicinal and edible substances or food, the safety is high, and the qi and blood replenishing and qi circulation promoting and stagnation removing effects are achieved. The perilla leaves are used as the medicine for promoting the circulation of qi, so that the qi can be supplemented without stagnation, and a better qi and blood supplementing effect can be realized.
Examples
Example 1
A beverage composition for invigorating qi and blood comprises the following raw materials: 10g of perilla leaf, 20g of peanut skin, 30g of cranberry, 15g of rose, 10g of angelica, 8g of ginseng and 5g of galangal.
The preparation method of the qi and blood replenishing drink composition comprises the following steps:
(1) weighing 10g of angelica, 8g of ginseng and 5g of galangal, adding 460g of water into the raw materials, decocting for 1 hour, and filtering to obtain a first extract;
(2) weighing 20g of peanut skin, 15g of rose and 10g of perilla leaf, adding 900g of water, soaking for 1 hour at 60 ℃, and filtering to obtain a second extract;
(3) weighing 30g of fresh cranberry, adding 80ml of water, cold pressing at low temperature, taking fruit juice, adding 0.06% of fruit juice 101 clarifier to treat, boiling at high temperature, cooling, centrifuging to take supernatant, and concentrating by nanofiltration for 8 times to obtain concentrated cranberry fruit juice.
(4) Mixing the first extract and the second extract, and mixing. Concentrated under reduced pressure to a relative density of 1.08(60 ℃). Precipitating the concentrate with 50% ethanol, standing at 4 deg.C for not less than 24 hr, centrifuging to obtain clear solution, concentrating under reduced pressure, removing ethanol, and adding cranberry juice. Adding 150g of hyaluronic acid aqueous solution with the mass concentration of 2%, 10g of 9 times of concentrated red date pulp and 0.2g of dragon fruit powder, adding water to 300g of the mixture, and uniformly mixing.
(5) Sterilizing, filtering and filling to obtain the finished product.
Example 2
Example 2 differs from example 1 in the amount of each raw material used, which comprises: 15g of perilla leaf, 35g of peanut skin, 10g of cranberry, 10g of rose, 18g of angelica, 5g of ginseng and 10g of galangal.
The preparation method of the qi and blood replenishing beverage composition is completely the same as that of the embodiment 1.
Example 3
Example 3 differs from example 1 only in the amount of 1g of perilla leaf.
The steps of the preparation method of the qi and blood replenishing drink composition are completely the same as those in the example 1.
Example 4
Example 4 is different from example 1 only in that 30g of perilla leaf was used.
The preparation method of the qi and blood replenishing beverage composition is completely the same as that of the embodiment 1.
Example 5
Example 5 differs from example 1 in the amount of each raw material used, which comprises: 3g of perilla leaves, 50g of peanut skin, 2g of cranberry, 5g of rose, 20g of angelica sinensis, 3g of ginseng and 2g of galangal.
The preparation method of the qi and blood replenishing beverage composition is completely the same as that of the embodiment 1.
Comparative example 1
Comparative example 1 is different from example 1 only in that perilla leaf is not contained in the raw materials and the contents of the other raw materials are the same as example 1. Namely, the raw materials comprise: 20g of peanut red skin, 30g of cranberry, 15g of rose, 10g of angelica, 8g of ginseng and 5g of galangal.
The preparation method of the qi and blood replenishing beverage composition is completely the same as that of the embodiment 1.
Comparative example 2
Comparative example 2 differs from example 1 only in that the raw materials do not contain peanut skin, and the content of each other raw material is the same as that of example 1. Namely, the raw materials comprise: 10g of perilla leaves, 30g of cranberry, 15g of rose, 10g of angelica, 8g of ginseng and 5g of galangal.
The preparation method of the qi and blood replenishing beverage composition is completely the same as that of the embodiment 1.
The raw material composition of each of the above examples and comparative examples is shown in table 1.
TABLE 1 raw material ratios in examples and comparative examples
Experimental example 1 evaluation of blood-enriching efficacy of different formulations on cyclophosphamide-induced blood-deficient mice
Animal grouping and administration
After the mice are bred adaptively for 7 days, the mice are randomly divided into 9 groups according to the weight, namely a normal group, a model group and an administration group 1-7# group, wherein each group comprises 10 mice, and the number of the mice is half that of the mice. Wherein the administration group ig administers 4 ml/kg of the composition prepared in each example and comparative example per day -1 For 14 days. The normal group and the model group ig were given an equal volume of physiological saline for 14 days. The model group and the administration group were administered daily on day 15 of administrationip cyclophosphamide 40 mg/kg -1 80 mg/kg of ig cyclophosphamide on day 18 for 3 days -1 (ii) a Normal group ip equal amount of saline. 2h after the last administration, the anal temperature of the mice is measured by one time; blood is taken from eyeballs by a blood collecting tube, heparin is used for anticoagulation, and peripheral hemogram, thymus index, spleen index and cell membrane ATP enzyme activity are measured.
Peripheral hemogram measurement: the detection is performed using a fully automatic blood analyzer, which mainly includes white blood cell count (WBC), Red Blood Cells (RBC), hemoglobin content (HGB), red blood cell Hematocrit (HCT), and platelet count (PLT).
Thymus index and spleen index determination: the mice after blood collection were sacrificed by taking off the cervical vertebrae, and the thymus and spleen were taken and weighed. Spleen Index (SI) and Thymus Index (TI) were calculated. The calculation formula is as follows: spleen mass and thymus mass were divided by the corresponding mouse body weight, respectively.
Determination of ATPase Activity: the determination is carried out by applying the principle of an inorganic phosphate radical method according to the specification of an ATP enzyme kit.
The measurement results are shown in tables 2 to 4.
TABLE 2 Effect of qi and blood drinks with different formulas on peripheral hemogram of blood deficiency model mouse: (
n＝10)
Note: comparison with Normal group 1 P<0.01; comparison with model group 2 P<0.01， 3 P<0.05
From the above results, it was found that the qi and blood replenishing drink 1-5# composition of the present invention significantly increased the body temperature level (P <0.01) of blood-deficient mice, and increased the hemogram levels of the mice, particularly the effects of example 2 and example 1, higher than those of the other groups. The indication shows that the prescription can exert the maximum effect only within the range of proper compatibility proportion. For example, in example 3, the effect of enriching the blood is affected because the consumption of perilla leaves is low, which causes weak qi-moving force, while in example 4, the effect of enriching the blood is greatly reduced because perilla leaves are reused, which causes too strong qi-moving force. In a comparative example, a perilla leaf-lack group and a peanut red coat-lack group are designed, compared with example 3 with less perilla leaf usage, when perilla leaf is not used at all (comparative example 1), the blood enriching effect is further reduced, which prompts the importance of qi-moving drugs on the blood enriching effect while enriching blood, and embodies the formulation idea of 'tonifying without stagnation'; in example 5, the amount of peanut skin was significantly increased compared to example 1, but the blood-enriching effect was not improved due to the decrease in the amount of perilla, and in comparative example 2, the peanut skin, which is the essential blood-enriching drug of the present invention, was removed, and thus the group exhibited no blood-enriching effect at all.
TABLE 3 Effect of qi-blood drinks with different formulas on ATP in blood deficiency model mice: (
n＝10)
Note: comparison with Normal group 1 P<0.01; comparison with model group 2 P<0.01， 3 P<0.05
From the results, the qi and blood replenishing drink 1-5# composition can remarkably increase Na of blood deficiency model mice + -K + ATPase and Ca 2+ -Mg 2+ The improvement effect of ATPase, especially 1-2# composition, is most obvious. The dosage of qi-moving herbs in the recipe-perilla leaf will be higher or lower to cause the decrease of curative effect.
TABLE 4 different formulations of qi and blood decoction versus blood deficiency model miceInfluence of organ index: (
n＝10)
Note: comparison with Normal group 1) P<0.01; comparison with model group 2) P<0.01， 3) P<0.05
The results show that the qi-blood drink can obviously increase the thymus index of a blood deficiency model mouse, has obvious effect of reducing the increased spleen index, and the strength of the drug effect is related to the prescription proportion.
Test example 2 evaluation of blood-enriching efficacy of different formulations on rats with blood deficiency caused by exsanguination
Animal grouping and administration
After the rats were bred for 7 days, the rats were randomly divided into 9 groups by weight, namely a normal group, a model group and a drug administration 1-7# group, wherein each group contains 8 females. Administration group ig the compositions prepared in examples and comparative examples were administered at a dose of 3 ml/kg/day -1 The normal group and the model group ig were given an equal volume of physiological saline. The administration is carried out 1 time per day for 30d continuously, the model is started at 18d, and the model group and the administration group are bled for 5ml/kg per day and continuously bled for 10 d. Blood is taken from fundus venous plexus 2h after the last administration, heparin is used for anticoagulation, and peripheral hemogram, thymus index, spleen index and cell membrane ATP enzyme activity are measured.
Peripheral hemogram measurement: the detection is carried out by a full-automatic blood analyzer, which mainly comprises Red Blood Cells (RBC), hemoglobin content (HGB), red blood cell Hematocrit (HCT) and platelet count (PLT).
Determination of ATPase Activity: the determination is carried out by applying the principle of an inorganic phosphate radical method according to the specification of an ATP enzyme kit.
The measurement results are shown in tables 5 to 6.
TABLE 5 Effect of different prescriptions of qi and blood decoction on peripheral hemogram of rat with blood deficiency model: (
n＝8)
Note: comparison with Normal group 1 P<0.01; comparison with model group 2 P<0.01， 3 P<0.05
From the above results, it can be seen that the compositions of examples 1 to 5 of the qi and blood replenishing drink of the present invention can significantly increase the blood levels of the blood-deficient rats, and particularly the compositions of examples 1, 2 and 5 have the most significant effects. Since this model is blood deficiency due to blood loss, the formulation of example 5 with stronger blood-enriching efficacy showed better blood-enriching effect. The components of examples 3 and 4 are characterized in that the amount of the qi-moving drug perilla leaf is changed compared with the formulation of example 1, but the perilla leaf is not used at all (comparative example 1), so that stagnation is easily caused, the blood-enriching efficacy cannot be exerted to the best, and the fact that the amount of the perilla leaf needs to be controlled within a certain range is suggested, and the blood-enriching effect of the composition is reduced when the amount of the perilla leaf is higher or lower. In contrast, comparative example 2 shows that the blood-enriching efficacy is almost not achieved by removing peanut skin in the formula.
TABLE 6 Effect of qi and blood decoction of different formulas on ATP in blood deficiency model rat
n＝8)
Note: comparison with Normal group 1 P<0.01； 2 P<0.05 comparison with model group 3 P<0.01， 4 P<0.05
From the above results, it was found that the compositions of examples 1 to 4 were capable of significantly increasing Na content in blood-deficiency model mice + -K + ATPase and Ca 2+ -Mg 2+ ATP enzyme, the composition of example 5 has a low dosage of peanut skin, and the effect is not obvious, and in comparative example 1, on the basis of the formula of example 1, perilla leaf is deleted, the blood enriching effect is also influenced to a certain extent, and the curative effect is slightly reduced.
Test example 3
Animal grouping and administration
After the experiment, all rats were placed in a constant temperature water tank [ (25 + -1) DEG C, water depth 40cm]And 3d, swimming for 5min every day. 1 day before grouping, exhaustive swimming is carried out after a weight with the body mass of minus 5% at the tail of the rat (the rat finally sinks to the nose tip and is immersed in water after swimming, and the rat can not return to the water surface after 10 seconds, namely the exhaustive swimming), rats with large difference of negative-gravity exhaustive swimming time (from swimming to the time of the occurrence of the exhaustive swimming) and without swimming are removed, and qualified rats with the negative-gravity exhaustive swimming time of 10-50 min are reserved. The qualified rats were randomly divided into a normal group, a model group, an administration group of examples and a comparative example, 8 rats each, according to body mass. The rats in the normal group are normally raised without special treatment; the other groups of rats adopt a 'diet irregularity + fatigue' method to construct the qi deficiency animal model: 9 a.m. each day: 00 exhaustive swimming in a constant temperature water tank by a weight with the tail part accounting for minus 5 percent of the body mass, and feeding the livestock in a feed limiting amount after 1 day of fasting for 21 days continuously. The administration group rats were gavaged with 3 ml/kg while molding -1 The qi and blood replenishing drink compositions of examples 1 to 5 and comparative examples 1 to 2 of the present invention, rats of the normal group and the model group were each gavaged with water of equal volume once a day for 21 days continuously. The negative gravity swimming time of rats was measured after the 21d dosing. The results are shown in Table 7.
TABLE 7 different prescriptions of qi-blood drinks on the weight bearing capacity of qi-deficiency model ratsInfluence of exhausted swimming time (
n＝8)
Note: comparison with Normal group 1 P<0.01； 2 P<0.05 comparison with model group 3 P<0.01， 4 P<0.05
The above results show that the qi and blood replenishing beverage composition can obviously prolong the negative gravity swimming time of the rats with qi deficiency models, and has good effects of replenishing qi and improving the tolerance of organisms, but the qi replenishing effect is reduced by removing the qi-moving perilla leaves or the blood replenishing peanut skin. Comparing examples 1 and 2, it can be seen that, under the condition of the same dosage of other medicines in the prescription, the peanut red skin and the perilla in example 2 are increased, and the qi-moving and blood-enriching effects are enhanced, so that better tolerance effect is shown, while in example 5, the peanut red skin dosage for enriching blood is increased, and the perilla dosage for promoting qi is decreased, so that the effect is slightly poor. The effect is also worse by removing the perilla in comparative example 1, but the blood-enriching effect cannot be better exerted by adding no peanut red skin in comparative example 2, so that the generation of qi and blood is passive, and thus, compared with a model group, almost no improvement is caused.
Claims (18)
1. The qi and blood replenishing beverage composition is characterized by being prepared from the following raw materials in parts by weight:
20-35 parts of peanut red skin;
5-30 parts of cranberry;
5-18 parts of rose;
when the weight is 5-18 parts;
5-15 parts of perilla leaves;
5-15 parts of ginseng;
and galangal in 3-12 weight portions.
2. The qi and blood replenishing beverage composition according to claim 1, wherein the raw materials of the composition further comprise one or more of hyaluronic acid, thickened red jujube pulp and a taste modifier.
3. The qi and blood replenishing beverage composition according to claim 1, wherein the preparation method of the composition comprises the following steps:
extracting radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum to obtain a first extract;
extracting peanut red skin, rose and perilla leaf to obtain a second extract;
preparing a concentrated cranberry juice;
preparing a qi and blood replenishing drink composition from the first extract, the second extract and the concentrated cranberry juice.
4. The qi and blood replenishing beverage composition according to claim 3, wherein the step of extracting Angelica sinensis, Panax ginseng and Alpinia officinarum to obtain the first extract comprises:
weighing radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum, adding water, decocting for 0.5-2h, and filtering to obtain a first extract, wherein the weight of the added water is 10-30 times of the total weight of radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum.
5. The qi and blood replenishing beverage composition according to claim 3, wherein the step of extracting the peanut red skin, the rose and the perilla leaf to obtain the second extract comprises:
weighing peanut skin, rose and perilla leaf, adding water, soaking for 0.5-2h, and filtering to obtain a second extract, wherein the mass of the added water is 10-30 times of the total mass of the peanut skin, rose and perilla leaf.
6. The qi and blood replenishing beverage composition according to claim 3, wherein the step of preparing the concentrated cranberry juice comprises:
weighing fresh cranberry fruits, adding water 2-4 times of the fresh cranberry fruits by weight, and cold-pressing to obtain cranberry juice;
adding juice clarifier into cranberry juice, clarifying, boiling at high temperature, cooling, centrifuging to obtain supernatant, and concentrating by nanofiltration 6-15 times to obtain concentrated cranberry juice.
7. The qi and blood replenishing beverage composition according to claim 3, wherein the step of preparing the qi and blood replenishing beverage composition from the first extract, the second extract and the concentrated cranberry juice comprises:
and uniformly mixing the first extract and the second extract, concentrating, refining, adding the concentrated cranberry juice, and adding water to dilute by 7-15 times to obtain the qi and blood replenishing beverage composition.
8. The qi and blood replenishing beverage composition according to claim 7, wherein one or more of hyaluronic acid, red date puree and taste modifier are further added before diluting with water in the step of preparing the qi and blood replenishing beverage composition from the first extract, the second extract and the concentrated cranberry juice.
9. The qi and blood replenishing beverage composition according to claim 7, wherein the refining is a precipitation treatment using ethanol, and the concentration of the selected ethanol is 40-60%.
10. The qi and blood replenishing beverage composition according to claim 7, wherein the refining is a precipitation treatment with ethanol, and the concentration of the selected ethanol is 45-55%.
11. The preparation method of the drink composition for tonifying qi and blood is characterized by comprising the following steps:
extracting radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum to obtain a first extract;
extracting peanut red skin, rose and perilla leaf to obtain a second extract;
preparing concentrated cranberry juice;
preparing a qi and blood replenishing drink composition from the first extract, the second extract and the concentrated cranberry juice;
based on the weight portion, the weight portion of the material,
20-35 parts of peanut red skin;
5-30 parts of cranberries;
5-18 parts of rose;
the angelica accounts for 5-18 parts;
5-15 parts of perilla leaves;
5-15 parts of ginseng;
and 3-12 parts of galangal.
12. The method of claim 11, wherein the step of extracting the first extract from the group consisting of angelica, ginseng, and galangal comprises:
weighing radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum, adding water, decocting for 0.5-2h, and filtering to obtain a first extract, wherein the weight of the added water is 10-30 times of the total weight of radix Angelicae sinensis, Ginseng radix and rhizoma Alpiniae Officinarum.
13. The method of claim 11, wherein the step of extracting the peanut red skin, the rose and the perilla leaf to obtain the second extract comprises:
weighing peanut skin, rose and perilla leaf, adding water, soaking for 0.5-2h, and filtering to obtain a second extract, wherein the mass of the added water is 10-30 times of the total mass of the peanut skin, the rose and the perilla leaf.
14. The method of making of claim 11, wherein the step of making the concentrated cranberry juice comprises:
weighing fresh cranberry, adding water 2-4 times of the fresh cranberry, and cold pressing to obtain cranberry juice;
adding juice clarifier into cranberry juice, clarifying, boiling at high temperature, cooling, centrifuging to obtain supernatant, and concentrating by nanofiltration 6-15 times to obtain concentrated cranberry juice.
15. The method of making of claim 11, wherein the step of making a qi and blood replenishing beverage composition from the first extract, the second extract, and the concentrated cranberry juice comprises:
and uniformly mixing, concentrating and refining the first extract and the second extract, adding the concentrated cranberry juice, and adding water to dilute by 7-15 times to obtain the qi and blood tonifying beverage composition.
16. The method of claim 15, wherein one or more of hyaluronic acid, red date puree, and taste modifier are further added before diluting with water in the step of preparing the qi and blood replenishing drink composition from the first extract, the second extract, and the concentrated cranberry juice.
17. The method of claim 15, wherein the refining is by ethanol precipitation, and the concentration of the selected ethanol is 40-60%.
18. The method of claim 15, wherein the refining is by ethanol precipitation, and the concentration of ethanol selected is 45-55%.
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