CN113133462A - Chlorine-containing disinfectant in low-temperature environment and preparation method thereof - Google Patents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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Abstract
The invention discloses a chlorine-containing disinfectant in a low-temperature environment and a preparation method thereof; the trichloroisocyanuric acid, calcium chloride, ethanol, isopropanol, allicin and the like are used as raw materials, and the powder A and the liquid B are formed by subpackaging, stirring, uniformly mixing and filtering through reasonable proportioning and standard processes, so that the trichloroisocyanuric acid disinfectant is suitable for disinfecting the surfaces of related articles in low-temperature and lower-temperature environments of 0 ℃, 20 ℃, 40 ℃, 80 ℃ and the like, and can keep the original liquid state in the low-temperature environment without freezing, crystallization and precipitation. The disinfectant has the characteristics of no toxicity, no corrosion, no stimulation, no residue, no flammability and the like; can effectively kill various bacteria such as staphylococcus aureus, escherichia coli, candida albicans and the like, as well as respiratory viruses such as coronavirus, influenza A virus and the like and enteroviruses, and the effective sterilization rate is 99.99 percent; can be automatically and uniformly mixed or manually prepared and uniformly mixed, and can be used for spraying, soaking, wiping and disinfecting articles in a low-temperature environment.
Description
Technical Field
The invention relates to the technical field of chlorine-containing disinfection, and particularly relates to a low-temperature environment chlorine-containing disinfectant and a preparation method thereof.
Background
The existing chlorine-containing disinfectant principle is mainly that the disinfectant is hydrolyzed in water to generate hypochlorous acid, and the hypochlorous acid has small volume and no charge and is easy to penetrate cell walls; meanwhile, hypochlorous acid is a strong oxidant, can damage cell membranes, releases substances such as protein, RNA and DNA and influences various enzyme systems (mainly oxidizing and destroying sulfydryl of phosphoglucose dehydrogenase), and accordingly, bacteria die. The effect of chlorine on viruses consists in lethal damage to nucleic acids. The chlorine-containing disinfectant is generally used in disinfection methods such as spraying (the diameter of a fog drop sprayed by a constant amount of spray is generally about 150-400 microns, and the diameter of a fog drop sprayed by an ultra-low volume spray is generally less than or equal to 50 microns), soaking, wiping and the like, but the existing mainstream chlorine-containing disinfectant has obvious defects in action temperature and has a relatively obvious disinfection effect at normal temperature, and under a low-temperature environment, particularly in low-temperature disinfection involving surface disinfection of low-temperature frozen articles in a cold chain, the disinfectant can be rapidly frozen due to the influence of temperature to form crystals and precipitate, the full action of the disinfectant and pathogenic microorganisms is seriously influenced, and the due disinfection effect cannot be achieved.
Disclosure of Invention
In order to overcome the defects of icing, crystallization, insufficient effect and the like of low-temperature disinfection in the prior disinfection technology, the invention provides a chlorine-containing disinfectant in a low-temperature environment and a preparation method thereof; the product quality meets the relevant standard specifications such as 'technical requirements for evaluating the sanitation and safety of disinfection products' (WS 628 plus 2018), 'technical specification for disinfection' (2002 edition), 'method for testing the sterilizing effect of a disinfectant laboratory' (GB/T38502 plus 2020) and 'program and method for evaluating the safety and toxicology of the disinfectant' (GB/T38496-2020), and the problems of icing, crystallization, precipitation, insufficient effect and the like in the disinfection implementation are solved while the disinfection effect is ensured.
The purpose of the invention is realized by the following technical scheme:
the invention relates to a chlorine-containing disinfectant for a low-temperature environment, which comprises a powder agent A and a liquid agent B; the powder agent A is trichloroisocyanuric acid; the liquid B agent comprises calcium chloride, an alcohol solvent and S-benzyl dimethyl dodecyl ammonium bromide (allicin, Latin: Allium); the alcohol solvent is ethanol or a mixed solvent of ethanol and isopropanol.
As an embodiment of the present invention, when the disinfectant is a low temperature disinfectant at-20 ℃, the liquid B agent is composed of an aqueous solution of calcium chloride, ethanol and allicin.
As an embodiment of the invention, when the disinfectant is used on site, the concentration of effective chlorine in the disinfectant at the low temperature of-20 ℃ is 5g/l, the content of anhydrous calcium chloride is 250-300 g/l, the content of ethanol is 80-100 g/l, and the content of allicin is 0.5 g/l.
As one embodiment of the invention, the low-temperature disinfectant at-20 ℃ is suitable for disinfecting the surfaces of the low-temperature environment at-20 ℃ and above and the outer package of the goods. Is preferably suitable for the surface disinfection of low-temperature environment of-20 ℃ to 4 ℃ and the outer package of the article.
As an embodiment of the present invention, when the disinfectant is a low temperature disinfectant at-40 ℃, the liquid B agent is composed of an aqueous calcium chloride solution, ethanol, isopropanol and allicin.
As an embodiment of the invention, when the disinfectant is used on site, the concentration of effective chlorine in the disinfectant at the low temperature of-40 ℃ is 5g/l, the content of anhydrous calcium chloride is 300-350 g/l, the content of ethanol is 90-100 g/l, the content of isopropanol is 80-100 g/l, and the content of allicin is 5 g/l.
As one embodiment of the invention, the low-temperature disinfectant at-40 ℃ is suitable for disinfecting the surfaces of the low-temperature environment at-40 ℃ and above and the outer package of the goods. Is preferably suitable for the surface disinfection of low-temperature environment of minus 40 ℃ to minus 21 ℃ and the outer package of the article.
As an embodiment of the present invention, when the disinfectant is a low temperature disinfectant at-80 ℃, the liquid B agent is composed of an aqueous calcium chloride solution, ethanol, isopropanol and allicin.
As an embodiment of the invention, when the disinfectant is used on site, the concentration of effective chlorine in the disinfectant at the low temperature of-80 ℃ is 5g/l, the content of anhydrous calcium chloride is 350-400 g/l, the content of ethanol is 95-100 g/l, the content of isopropanol is 90-100 g/l, and the content of allicin is 50 g/l.
As one embodiment of the invention, the low-temperature disinfectant at-80 ℃ is suitable for disinfecting the surfaces of the low-temperature environment at-80 ℃ and above and the outer package of the goods. Preferably applicable to the low-temperature environment of minus 80 ℃ to minus 41 ℃ and the surface sterilization of the outer package of the article. In the low-temperature disinfectant system, the disinfection effect of the isopropanol on the surface of an object is obviously higher than that of ethylene glycol, propylene glycol, ethanol and the like; the disinfection in low-temperature environment does not usually involve air disinfection in space, mainly takes wiping or spraying on the surface of an object, and has better effect than ethanol, ethylene glycol and propylene glycol. Especially for viral microorganisms, its proteins can be immediately coagulated, leading to the death of the microorganism. Can kill bacteria propagules and destroy most lipophilic viruses such as herpes simplex virus, hepatitis B virus, and human immunodeficiency virus. Therefore, when the disinfectant with the low temperature of-40 ℃ and the disinfectant with the low temperature of-80 ℃ are prepared, a specific amount of isopropanol needs to be added.
The invention also relates to a preparation method of the chlorine-containing disinfectant in the low-temperature environment, which comprises the following steps:
s1, directly subpackaging trichloroisocyanuric acid to obtain a powder A;
s2, dissolving calcium chloride in water, fully dissolving and filtering; adding ethanol or mixture of ethanol and isopropanol, and allicin, stirring, mixing, and filtering; liquid agent B is obtained.
The invention also relates to a using method of the chlorine-containing disinfectant in the low-temperature environment, which comprises the following steps:
a. spraying and disinfecting: the spraying amount is about 250-500 mL/m when the disinfectant is matched with disinfection equipment3Ensuring that the disinfectant fully covers the disinfection object in a sufficient amount, and the disinfection action time is 10-30 min;
b. soaking and disinfecting: directly soaking in disinfectant for 10-30 min;
c. wiping and disinfecting: ensuring that the disinfectant covers the disinfection object in sufficient quantity, and the disinfection action time is 10-30 min.
As an embodiment of the invention, when the disinfectant is a low-temperature disinfectant at-20 ℃, the disinfectant is suitable for disinfecting the surfaces of the low-temperature environment at-20 ℃ to 4 ℃ and the outer package of the article; when the disinfectant is a low-temperature disinfectant at minus 40 ℃, the disinfectant is suitable for disinfecting the surfaces of the low-temperature environment and the outer package of the article at minus 40 ℃ to minus 21 ℃; when the disinfectant is a low-temperature disinfectant at the temperature of minus 80 ℃ to minus 41 ℃, the low-temperature environment and the surface of the outer package of the article are disinfected.
Compared with the prior art, the invention has the following beneficial effects:
1) allicin can cause S-thioallylation of main protease in virus such as new coronavirus, inhibit enzyme activity to prevent virus replication and reproduction, thereby inhibiting or killing virus, and is helpful for preventing and treating new coronavirus.
2) Has the characteristics of sterilization, anti-corrosion, strong corrosion reduction and the like.
3) The used neutralizer is thoroughly neutralized, can be used for inhibiting bacteria for a long time and has no resurgence and rebound.
4) Broad spectrum, high efficiency, no poison, irritation, corrosion and residue.
5) Is suitable for normal temperature, low temperature and ultralow temperature environments.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a schematic diagram of the preparation process of the chlorine-containing disinfectant for low-temperature environment of the present invention.
Detailed Description
The present invention will be described in detail with reference to examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be apparent to those skilled in the art that several modifications and improvements can be made without departing from the inventive concept. All falling within the scope of the present invention.
Example 1
This example relates to a low temperature disinfectant at-20 deg.C, a low temperature disinfectant at-40 deg.C, and a low temperature disinfectant at-80 deg.C; the method comprises the following specific steps:
low temperature disinfectant compositions and dosage forms
(I) -20 ℃ low-temperature disinfectant (with the temperature of-20-4 ℃)
1. The main components are as follows: including trichloroisocyanuric acid, calcium chloride, ethanol and allicin. When in use on site, A, B agents are mixed and diluted, and the concentration of effective chlorine in the disinfectant at the low temperature of-20 ℃ is 0.5 percent (5000mg/L), the content of calcium chloride is 25 to 30 percent, the content of ethanol is 8.0 to 10.0 percent, and the content of allicin is 0.05 percent.
2. The preparation formulation is as follows: binary package, powder and liquid are adopted. The agent A is trichloroisocyanuric acid powder/granular solid, and the agent B is a mixed aqueous solution of calcium chloride, ethanol and allicin. Can be automatically mixed or manually prepared and mixed.
(II) -40 ℃ low-temperature disinfectant (the temperature is-40 ℃ to-21 ℃)
1. The main components are as follows: including trichloroisocyanuric acid, calcium chloride, ethanol, isopropanol and allicin. When in use on site, A, B agents are mixed and diluted, the concentration of effective chlorine in the disinfectant at the low temperature of minus 40 ℃ is 0.5 percent (5000mg/L), the content of calcium chloride is 30 to 35 percent, the content of ethanol is 9.0 to 10.0 percent, the content of isopropanol is 8.0 to 10.0 percent, and the content of allicin is 0.5 percent.
2. The preparation formulation is as follows: binary package, powder and liquid are adopted. The agent A is trichloroisocyanuric acid powder; the agent B is a mixed aqueous solution of calcium chloride, ethanol, isopropanol and allicin.
(III) -80 ℃ low-temperature disinfectant (the temperature is-80 ℃ to-41 ℃)
1. The main components are as follows: including trichloroisocyanuric acid, calcium chloride, ethanol, isopropanol and allicin. When in use on site, A, B agents are mixed and diluted, the concentration of effective chlorine in the disinfectant at the low temperature of minus 80 ℃ is 0.5 percent (5000mg/L), the content of calcium chloride is 35 to 40 percent, the content of ethanol is 9.0 to 10.0 percent, the content of isopropanol is 9.0 to 10.0 percent, and the content of allicin is 5.0 percent.
2. The preparation formulation is as follows: binary package, powder and liquid are adopted. The agent A is trichloroisocyanuric acid powder; the agent B is a mixed aqueous solution of calcium chloride, ethanol, isopropanol and allicin.
Preparation of low-temperature disinfectant
Raw materials and preparation process: the components are prepared according to the formula requirements and are shown in tables 1, 2 and 3 in detail.
During preparation, calcium chloride is dissolved in proper amount of water, and the mixture is filtered, ethanol and garlicin are added, mixed and filtered to form liquid preparation B.
The trichloroisocyanuric acid is directly packed to obtain the powder A.
TABLE 1-20 deg.C low temperature (4 deg.C-20 deg.C) disinfectant ingredient Table (take 1000L as an example)
TABLE 2-disinfectant Components at Low temperature of-40 deg.C (-21 deg.C-40 deg.C) (1000L as an example)
TABLE 3-80 ℃ Low temperature (-80 ℃ C. to-41 ℃ C.) disinfectant ingredient Table (taking 1000L as an example)
Application range and method of low-temperature disinfectant
(one) application Range
The low-temperature disinfectant at the temperature of minus 20 ℃ is suitable for disinfecting the surfaces of the outer packages of the articles and the low-temperature environment at the temperature of minus 20 ℃ and above; the low-temperature disinfectant at the temperature of minus 40 ℃ is suitable for disinfecting the surfaces of the outer packages of the articles and the low-temperature environment at the temperature of minus 40 ℃ and above; the disinfectant at the low temperature of minus 80 ℃ is suitable for disinfecting the surfaces of the outer packages of the articles and the low-temperature environment at the temperature of minus 80 ℃ and above.
(II) method of use
1. The specific method comprises the following steps: according to the table 1, 2 and 3, the agent A and the agent B of the disinfectant with low temperature of-20 ℃, the disinfectant with low temperature of-40 ℃ or the disinfectant with low temperature of-80 ℃ are fully and evenly mixed with water, and can be automatically and evenly mixed or manually prepared and evenly mixed. And then loading into a sterilizing instrument for performing low-temperature environment sterilization, and particularly referring to fig. 1.
2. Spraying and disinfecting: the spraying amount is about 250-500 mL/m when the disinfectant is matched with disinfection equipment3And ensuring that the low-temperature disinfectant fully covers the disinfected object for 15-30 min.
3. Soaking and disinfecting: directly putting the mixture into a low-temperature disinfectant, and completely immersing the mixture for 15-30 min.
4. Wiping and disinfecting: ensuring that the low-temperature disinfectant covers the disinfection object in a sufficient amount, and the disinfection action time is 15-30 min.
(III) verification of Performance
1. The formula of the neutralizer is as follows: 2.1% lecithin, 2.0% glucose, 2.4% sodium thiosulfate, 1.5% tween 80, 0.5% peptone, 1.2% sodium sulfite;
2. neutralizer identification test (Disinfection Specification 2002 edition 2.1.1.5.5)
Nutrient agar medium, Trypticase Soy Agar (TSA), and blood agar medium
Disinfectant, test bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Aspergillus niger, Staphylococcus albus, Mycobacterium cheloniae, Bacillus subtilis spore, poliovirus), neutralizer (added into culture medium for use in evaluating disinfection effect),
and evaluating the growth and reproduction of the test bacteria by the residual disinfectant with the killing or bacteriostasis effect and incomplete neutralization.
The results of colony control and negative control show that the disinfectant of each example has the effect of more than 5.00 on bacteria and viruses and is effective at-20 ℃, 40 ℃ and 80 ℃. The phenomenon of restoring growth and reproduction is avoided.
3. Quantitative sterilization test
Selection of positive and negative controls, stock 1: 5 Dilute, 2.5% neutralization with sodium thiosulfate
And (3) disinfection time: immediate (< 5 minutes), 5 minutes, 10 minutes, 15 minutes, 30 minutes;
the results show that: the disinfectant of the embodiment has the effect of more than 5.00 on bacteria and viruses and is effective at the temperature of-20 ℃, 40 ℃ and 80 ℃.
In conclusion, the invention takes trichloroisocyanuric acid, calcium chloride, ethanol, isopropanol, S-benzyl dimethyl dodecyl ammonium bromide (hereinafter referred to as allicin) and the like as raw materials, forms a powder agent A and a liquid agent B by split charging, stirring, uniformly mixing and filtering through reasonable proportioning and standard processes, is suitable for surface disinfection of related articles in the environments of 0 ℃, 20 ℃, 40 ℃, 80 ℃ and lower temperature, meets the requirement of the technical requirement of supervision of the national health and health commission office on the printing and issuing low-temperature disinfectant sanitation safety evaluation (national health office code No. 2020, No. 1062) in a low-temperature environment, can keep the original liquid state in the low-temperature environment, and has no icing, crystallization and precipitation. The disinfectant has the characteristics of no toxicity, no corrosion, no stimulation, no residue, no flammability and the like; can effectively kill various bacteria such as staphylococcus aureus, escherichia coli, candida albicans and the like and viruses such as coronavirus, influenza A virus and the like, and the effective sterilization rate is 99.99 percent; can be automatically and uniformly mixed or manually prepared and uniformly mixed, and can be used for spraying, soaking, wiping and disinfecting articles in a low-temperature environment.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.
Claims (10)
1. A chlorine-containing disinfectant for low-temperature environments is characterized by comprising a powder agent A and a liquid agent B; the powder agent A is trichloroisocyanuric acid; the liquid B agent comprises calcium chloride, an alcohol solvent and allicin; the alcohol solvent is ethanol or a mixed solvent of ethanol and isopropanol.
2. The low-temperature environment chlorine-containing disinfectant as claimed in claim 1, wherein when the disinfectant is a low-temperature disinfectant at-20 ℃, the liquid B agent is composed of calcium chloride aqueous solution, ethanol and allicin.
3. The low-temperature environment chlorine-containing disinfectant as claimed in claim 2, wherein when the disinfectant is used on site, the concentration of available chlorine in the low-temperature disinfectant at-20 ℃ is 5g/l, the content of anhydrous calcium chloride is 250-300 g/l, the content of ethanol is 80-100 g/l, and the content of allicin is 0.5 g/l.
4. The low-temperature environment chlorine-containing disinfectant as claimed in claim 1, wherein when the disinfectant is a low-temperature disinfectant at-40 ℃, the liquid B agent is composed of calcium chloride aqueous solution, ethanol, isopropanol and allicin.
5. The low-temperature environment chlorine-containing disinfectant as claimed in claim 4, wherein, when used on site, the low-temperature disinfectant at-40 ℃ has an effective chlorine concentration of 5g/l, anhydrous calcium chloride content of 300-350 g/l, ethanol content of 90-100 g/l, isopropanol content of 80-100 g/l, and allicin content of 5 g/l.
6. The low-temperature environment chlorine-containing disinfectant as claimed in claim 1, wherein when the disinfectant is a low-temperature disinfectant at-80 ℃, the liquid B agent is composed of calcium chloride aqueous solution, ethanol, isopropanol and allicin.
7. The low-temperature environment chlorine-containing disinfectant as claimed in claim 6, wherein, when used on site, the low-temperature disinfectant at-80 ℃ has an effective chlorine concentration of 5g/l, anhydrous calcium chloride content of 350-400 g/l, ethanol content of 95-100 g/l, isopropanol content of 90-100 g/l, and allicin content of 50 g/l.
8. The preparation method of the chlorine-containing disinfectant for the low-temperature environment according to any one of claims 1 to 7, wherein the method comprises the following steps:
s1, directly subpackaging trichloroisocyanuric acid to obtain a powder A;
s2, dissolving calcium chloride in water, fully dissolving and filtering; adding ethanol or mixture of ethanol and isopropanol, and allicin, stirring, mixing, and filtering; liquid agent B is obtained.
9. The use method of the chlorine-containing disinfectant for the low-temperature environment according to any one of claims 1 to 7, wherein the method comprises the following steps:
a. spraying and disinfecting: the spraying amount is about 250-500 mL/m when the disinfectant is matched with disinfection equipment3Ensuring that the disinfectant fully covers the disinfection object in a sufficient amount, and the disinfection action time is 10-30 min;
b. soaking and disinfecting: directly soaking in disinfectant for 10-30 min;
c. wiping and disinfecting: ensuring that the disinfectant covers the disinfection object in sufficient quantity, and the disinfection action time is 10-30 min.
10. The use method of the chlorine-containing disinfectant in the low-temperature environment according to claim 1, wherein the disinfectant is suitable for disinfecting the surfaces of the articles and the outer packages in the low-temperature environment of-20 ℃ to 4 ℃ when being a low-temperature disinfectant at-20 ℃; when the disinfectant is a low-temperature disinfectant at minus 40 ℃, the disinfectant is suitable for disinfecting the surfaces of the low-temperature environment and the outer package of the article at minus 40 ℃ to minus 21 ℃; when the disinfectant is a low-temperature disinfectant at the temperature of minus 80 ℃ to minus 41 ℃, the low-temperature environment and the surface of the outer package of the article are disinfected.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114794091A (en) * | 2022-03-15 | 2022-07-29 | 北京可佳永好科贸有限公司 | Low-temperature disinfection powder and preparation method and application thereof |
| CN115486448A (en) * | 2022-09-19 | 2022-12-20 | 中国疾病预防控制中心病毒病预防控制所 | Low-temperature disinfectant for inactivating SARS-CoV-2 virus at-80 DEG C |
| CN115486448B (en) * | 2022-09-19 | 2024-04-30 | 中国疾病预防控制中心病毒病预防控制所 | Low-temperature disinfection solution for inactivating SARS-CoV-2 virus at-80 DEG C |
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