CN113116771B

CN113116771B - Repairing type water replenishing horse oil cream and preparation method thereof

Info

Publication number: CN113116771B
Application number: CN202110210256.5A
Authority: CN
Inventors: 陈出新
Original assignee: Hubei Yanzhuang Industrial Co ltd
Current assignee: Hubei Yanzhuang Industrial Co ltd
Priority date: 2021-02-24
Filing date: 2021-02-24
Publication date: 2022-07-22
Anticipated expiration: 2041-02-24
Also published as: CN113116771A

Abstract

The invention discloses a repairing type water-replenishing horse oil cream and a preparation method thereof, and the horse oil cream comprises 0.1-5.0 parts of horse fat, 0.5-10.0 parts of jojoba seed oil, 2.01-67.0 parts of a skin conditioner, 0.25-11.0 parts of a thickening agent, 0.1-10.0 parts of an emulsion stabilizer, 0.02-1.2 parts of a chelating agent, 2.51-101.0 parts of a humectant and 50-100 parts of deionized water. The horse oil cream disclosed by the invention is easy to absorb, can fully play the water replenishing and moisturizing effects of nutritional ingredients on skin, and meanwhile, promotes skin metabolism, regulates grease secretion and repairs damaged cells of the skin. The product produced by the preparation method has obvious effects of moisturizing and locking water for the skin and repairing the skin, has good stability, does not have the phenomena of cracking and layering due to long-time shelf, and can prolong the shelf life of the product without adding a preservative.

Description

Repairing type water replenishing horse oil cream and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, and particularly relates to a repair type water replenishing horse oil cream and a preparation method thereof.

Background

The total weight of the skin accounts for 5-15% of the human body weight, the total area is 1.5-2 square meters, and the thickness is 0.5-4 millimeters. The skin has two barrier functions, namely, on one hand, the loss of water, electrolytes and other substances in the body is prevented, on the other hand, the invasion of external harmful substances is prevented, the stability of the internal environment of the human body is kept, the physiologically important protection function is played, and meanwhile, the skin also participates in the metabolic process of the human body. Skin is constantly aging, slowly decreasing in elasticity, becoming thinner, more fragile and looser. Skin aging is generally natural aging and photoaging. The former mainly refers to aging caused by non-resistant factors existing in the body such as heredity, gravity, endocrine and immune functions with the aging; the latter is mainly due to the action of ultraviolet rays, which accelerates the process of natural aging, and a series of environmental exposures such as climate change, environmental pollution and the like also have direct influence on the photoaging of the skin.

Horse oil is also known as horse fat and is used as a skin conditioner in cosmetics. Horse oil is extracted from fat under the horsehair or at the neck, and Japan is the first country to apply for safety certification for the extracted horse oil. The horse oil contains a large amount of linoleic acid and has very strong penetrability. The components of human sweat and that of horse sweat are very similar in proportion, except that a small amount of 'saturated fatty acid' forms a protective film on the surface of skin, and a large amount of unsaturated components are absorbed by the skin, especially the fatty acid is required to effectively participate in the metabolic function of human skin tissues, so that the sweat plays a very important role in repairing damaged cells of the skin. Generally, the storage fat of animals contains unsaturated fatty acid alpha-linolenic acid not more than 1%, but the horse fat contains alpha-linolenic acid and linoleic acid more than 15%. Therefore, the horse oil is rich in unsaturated fatty acid, has good spreadability and lubricating feeling, can promote the activity of in vitro tissues such as scalp, nails and the like, has good penetration and nourishing functions on skin and hair, and belongs to nutritional grease.

Horse oil has the repairing effect on skin aging caused by aging and external environment, but horse oil skin care products in the prior art have the problems of being thick, heavy, sticky, oily and difficult to absorb, and many repairing face creams contain a lot of substances harmful to human skin such as preservatives, hormones and heavy metals, so that the side effect on the skin is great under the condition of long-term and long-term use.

Disclosure of Invention

The invention aims to provide a repairing type water-replenishing horse oil cream and a preparation method thereof.

In order to realize the purpose, the invention is realized by the following technical scheme:

the first purpose of the invention is to provide a repairing type water-replenishing horse oil cream which comprises, by weight, 0.1-5.0 parts of horse fat, 0.5-10.0 parts of jojoba seed oil, 2.01-67.0 parts of a skin conditioner, 0.25-11.0 parts of a thickening agent, 0.1-10.0 parts of an emulsion stabilizer, 0.02-1.2 parts of a chelating agent, 2.51-101.0 parts of a humectant and 50-100 parts of deionized water;

the skin conditioner comprises 0.01-1.0 part of sodium hyaluronate, 0.5-10.0 parts of betaine, 0.1-10.0 parts of phytosterol oleate, 0.1-10.0 parts of sweet almond oil, 0.1-10.0 parts of tangerine peel oil, 0.1-10.0 parts of hydrogenated vegetable oil, 0.05-1.0 part of bisabolol, 0.05-3.0 parts of perilla leaf extract and 0.05-3.0 parts of glycyrrhiza glabra root extract;

the thickening agent comprises 0.05-1.0 part of xanthan gum;

the chelating agent comprises 0.01-0.2 part of EDTA disodium;

the humectant comprises 1.5-60.0 parts of butanediol and 0.5-30.0 parts of glycerol.

Further, the thickening agent also comprises one or two of a sodium polyacrylate/C13-14 isoparaffin/tridecyl alcohol polyether-6 composition or a hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer; 0.1-5.0 parts of sodium polyacrylate/C13-14 isoparaffin/tridecyl alcohol polyether-6 composition and 0.1-5.0 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

Furthermore, the mass ratio of the sodium polyacrylate to the C13-14 isoparaffin to the tridecyl polyether-6 in the sodium polyacrylate/C13-14 isoparaffin/tridecyl polyether-6 composition is 1: 1: 1.

further, the skin conditioning agent also comprises 0.01-1.0 part of allantoin and 0.5-10.0 parts of polydimethylsiloxane.

Further, the skin conditioning agent also comprises 0.5-10.0 parts of glycerin acrylate/acrylic acid copolymer, glycerin, propylene glycol and PVM/MA copolymer.

Further, the skin conditioner also comprises one or more of scutellaria baicalensis root extract, kochia scoparia extract, magnolia biondii bud/flower extract, dictamnus dasycarpus root extract, centella asiatica extract, peony root extract and saposhnikovia divaricata root extract, and the addition amount of the extracts is 0.05-3.0 parts.

Further, the skin conditioner also comprises 0.1-10.0 parts of vitamin E.

Further, the humectant also comprises 0.01-1.0 part of ethylhexyl glycerin and 0.5-10.0 parts of hydroxyethyl urea aqueous solution, wherein the mass concentration of the hydroxyethyl urea aqueous solution is 20-50%; the chelating agent also comprises 0.01-1.0 caprylyl hydroximic acid.

The second purpose of the invention is to provide a preparation method of the repair type water replenishing horse oil cream, which comprises the following steps:

(1) weighing water and EDTA disodium according to a certain amount, adding the water and the EDTA disodium into an emulsifying pot, heating to 80 ℃, then weighing xanthan gum, 0.5-20 parts of butanediol, 0.5-30 parts of glycerol, an emulsion stabilizer and sodium hyaluronate into a clean barrel, stirring, wetting and dispersing uniformly, adding the materials into the emulsifying pot for 2-3 times, keeping vacuum, starting stirring and homogenizing for 5 minutes until the materials are completely dissolved uniformly to form an A-phase material;

(2) weighing phytosterol oleate, jojoba seed oil and horse fat according to the weight, adding into an oil pan, stirring and dissolving uniformly, and heating to 75-80 ℃; adding sweet almond oil, tangerine peel oil and hydrogenated vegetable oil into the oil pan when the temperature in the oil pan reaches 80 ℃ to form a B-phase material;

(3) starting an emulsifying pot, stirring in vacuum, pumping the B-phase material in the oil pot into the emulsifying pot, and keeping vacuum rapid stirring and uniform dispersion;

(4) weighing betaine, bisabolol, folium Perillae extract and radix Glycytthizae extract at a certain proportion, adding into emulsifying pan at 40-45 deg.C, stirring for 10 min, sampling, inspecting, and discharging after qualified.

Further, the method comprises the following steps:

(1) weighing water, allantoin and EDTA disodium according to a certain weight, adding the water, the allantoin and the EDTA disodium into an emulsifying pot, heating the mixture to 80 ℃, then weighing xanthan gum, 0.5-20 parts of butanediol, 0.5-30 parts of glycerol, an emulsion stabilizer and sodium hyaluronate into a clean barrel, stirring, wetting and dispersing uniformly, adding the mixture into the emulsifying pot for 2-3 times, keeping vacuum, starting stirring and homogenizing for 5 minutes until the mixture is completely dissolved uniformly to form an A-phase material;

(2) weighing phytosterol oleate, jojoba seed oil, polydimethylsiloxane and horse fat according to the weight, adding into an oil pan, stirring and dissolving uniformly, and heating to 75-80 ℃; adding sweet almond oil, tangerine peel oil and hydrogenated vegetable oil into the oil pan when the temperature in the oil pan reaches 80 ℃ to form a B-phase material;

(3) starting the emulsifying pot, vacuumizing and stirring, pumping the B-phase material in the oil pot into the emulsifying pot, and keeping vacuum, quickly stirring and uniformly dispersing;

(4) weighing p-hydroxyacetophenone according to the amount and pre-dissolving the p-hydroxyacetophenone and 0.5 to 20 parts of butanediol at the temperature of between 65 and 70 ℃ to form a C-phase material uniformly; weighing the sodium polyacrylate/C13-14 isoparaffin/tridecyl alcohol polyether-6 composition according to the weight, adding into an emulsifying pot, stirring and homogenizing for 1 minute, then adding the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and stirring at a medium speed for 30 minutes under vacuum; after stirring, opening the kettle, cooling to 60 ℃, and adding a C-phase material pre-dissolved uniformly in advance;

(5) weighing 0.5-20 parts of butanediol, caprylyl hydroximic acid and ethylhexyl glycerin according to the weight, and pre-dissolving uniformly at 65-70 ℃ to form a D-phase material; adding the pre-dissolved D-phase material when the temperature in the emulsifying pot is reduced to 50 ℃;

(6) weighing one or more of betaine, bisabolol, hydroxyethyl urea aqueous solution, vitamin E, glycerol acrylate/acrylic acid copolymer, glycerol, propylene glycol, PVM/MA copolymer, perilla leaf extract, glycyrrhiza glabra root extract, scutellaria root extract, kochia scoparia fruit extract, magnolia biondii bud/flower extract, dictamnus dasycarpus root extract, centella asiatica extract, peony root extract and radix sileris root extract according to the weight, adding the mixture into an emulsifying pot at the temperature of between 40 and 45 ℃, stirring the mixture for 10 minutes uniformly, sampling and inspecting the mixture, and discharging the mixture after the mixture is qualified.

Compared with the prior art, the invention has the following beneficial technical effects:

(1) experiments prove that the perilla leaf extract and the tangerine peel oil in an optimized ratio are added in the formula, so that on one hand, the hyaluronic acid is strongly promoted to generate hyaluronidase, the hyaluronic acid can be better depolymerized and loosened, the local accumulated liquid is promoted to be diffused quickly, the local accumulated liquid is easier to absorb, and the water replenishing and moisturizing effects of water replenishing nutrient components on skin are fully exerted; on the other hand, the composition can act together with jojoba seed oil, betaine and phytosterol oleate with optimized proportion, so that pores can be unblocked, the permeability and the water absorption of skin are improved, meanwhile, the saturated fatty acid alpha-linolenic acid in horse fat is fully absorbed, the skin metabolism is promoted, the oil secretion is regulated, and the damaged cells of the skin are repaired. Even if the skin suffers from a great loss of cell osmolytes when high osmotic pressure of the external environment is applied, the equine oil cream can inhibit the process to a certain extent, and the balance of cells is protected through the penetration of the skin cuticle.

(2) The sweet almond oil added in the formula disclosed by the invention is moisture-keeping, soothing and anti-allergy, the hydrogenated vegetable oil is rich in various vitamins required by skin metabolism, and the vitamin and the hydrogenated vegetable oil interact to be soft, smooth and not greasy, and can isolate ultraviolet rays; when the glycyrrhiza glabra root extract with the optimized proportion is added when the disodium EDTA is taken as the chelating agent, the antioxidant capacity of the glycyrrhiza glabra root is further enhanced, the glycyrrhiza glabra root extract has the effects of skin decoloration and speckle reduction, and the skin aging process is delayed.

(3) According to the invention, horse fat is taken as a basic emollient, and butanediol and glycerol in an optimized proportion are matched to be taken as moisturizers, so that a special soothing and moisturizing film is formed on the surface of skin, the skin cuticle is prevented from being dried and cracked due to water shortage, dermatitis is inhibited, and ultraviolet rays are isolated, and the skin is softer, more smooth and not greasy.

(4) Experiments show that when the bisabolol and the hydroxyethyl urea aqueous solution with the optimized proportion are added, the moisturizing effect of the sodium hyaluronate and the skin repairing effect of the horse fat are more remarkable.

(5) The product produced by the preparation method of the horse oil cream has remarkable effects of moisturizing and locking water for skin and repairing skin, has good stability, does not crack or delaminate due to long-time shelf, can still damage the coexistence environment of bacteria under the condition of not adding a preservative, and prolongs the shelf life of the product.

Detailed Description

The following examples are presented to illustrate certain embodiments of the invention in particular and should not be construed as limiting the scope of the invention. The present disclosure may be modified from materials, methods, and reaction conditions at the same time, and all such modifications are intended to be within the spirit and scope of the present invention. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art. The reagents and biological materials are commercially available, unless otherwise specified.

In the sodium polyacrylate/C13-14 isoparaffin/tridecyl alcohol polyether-6 composition, the mass ratio of the sodium polyacrylate to the C13-14 isoparaffin to the tridecyl alcohol polyether-6 is 1: 1: 1.

example 1:

a repair type water replenishing horse oil cream comprises 0.1 part of horse fat, 5.0 parts of jojoba seed oil, 0.01 part of sodium hyaluronate, 0.5 part of betaine, 0.1 part of phytosterol oleate, 0.1 part of sweet almond oil, 0.1 part of tangerine peel oil, 0.1 part of hydrogenated palm oil, 0.5 part of bisabolol, 0.05 part of perilla leaf extract, 0.05 part of glycyrrhiza glabra root extract, 0.05 part of xanthan gum, 0.01 part of disodium EDTA, 0.5 part of butanediol, 0.5 part of glycerol, 5.0 parts of an emulsion stabilizer ammonium acryloyl dimethyltaurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer and 75 parts of deionized water.

The preparation method of the repair type water replenishing horse oil cream comprises the following steps:

(1) weighing water and EDTA disodium according to a certain amount, adding the water and the EDTA disodium into an emulsifying pot, heating to 80 ℃, then weighing xanthan gum, butanediol, glycerol, the acryloyl dimethyl ammonium taurate/docosyl polyether-25 methacrylate cross-linked polymer and the sodium hyaluronate into a clean barrel, stirring, wetting and dispersing uniformly, adding the mixture into the emulsifying pot for 2-3 times, keeping vacuum, starting stirring and homogenizing for 5 minutes until the mixture is completely dissolved uniformly to form a phase A material;

(2) weighing phytosterol oleate, jojoba seed oil and horse fat according to the amount, adding into an oil pan, stirring and dissolving uniformly, and heating to 75-80 deg.C; adding sweet almond oil, tangerine peel oil and hydrogenated vegetable oil into the oil pan when the temperature in the oil pan reaches 80 ℃ to form a B-phase material;

Example 2:

a repair type water-replenishing horse oil cream comprises 2.5 parts of horse fat, 10.0 parts of jojoba seed oil, 0.5 part of sodium hyaluronate, 10.0 parts of betaine, 5.0 parts of phytosterol oleate, 5.0 parts of sweet almond oil, 5.0 parts of tangerine peel oil, 5.0 parts of hydrogenated palm oil, 1.0 part of bisabolol, 2.5 parts of perilla leaf extract, 2.5 parts of glycyrrhiza glabra root extract, 0.5 part of xanthan gum, 0.2 part of EDTA disodium, 10 parts of butanediol, 15 parts of glycerol, 0.1 part of an emulsion stabilizer of acryloyl dimethyl ammonium taurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer and 100 parts of deionized water.

The preparation method is the same as example 1.

Example 3:

a repair type water-replenishing horse oil cream comprises 5.0 parts of horse fat, 0.5 part of jojoba seed oil, 1.0 part of sodium hyaluronate, 5.0 parts of betaine, 10.0 parts of phytosterol oleate, 10.0 parts of sweet almond oil, 10.0 parts of tangerine peel oil, 10.0 parts of hydrogenated palm oil, 0.05 part of bisabolol, 3.0 parts of perilla leaf extract, 3.0 parts of glycyrrhiza glabra root extract, 1.0 part of xanthan gum, 0.1 part of EDTA disodium, 20 parts of butanediol, 30 parts of glycerol, 10.0 parts of an emulsion stabilizer of acryloyl dimethyl ammonium taurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer and 50 parts of deionized water.

The preparation method is the same as example 1.

Example 4:

a repair type water-replenishing horse oil cream comprises 0.1 part of horse fat, 5.0 parts of jojoba seed oil, 0.01 part of sodium hyaluronate, 0.5 part of betaine, 0.1 part of phytosterol oleate, 0.1 part of sweet almond oil, 0.1 part of tangerine peel oil, 0.1 part of hydrogenated palm oil, 0.5 part of bisabolol, 0.05 part of perilla leaf extract, 0.05 part of glabrous licorice root extract, 0.05 part of xanthan gum and 0.01 part of EDTA disodium, 1.5 parts of butanediol, 0.5 part of glycerol, 5.0 parts of an emulsion stabilizer ammonium acryloyldimethyl taurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer, 0.5 part of allantoin, 0.1 part of sodium polyacrylate, C13-14 isoparaffin, a tridecyl alcohol polyether-6 composition, 0.1 part of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.05 part of p-hydroxyacetophenone, 0.01 part of ethylhexyl glycerol, 0.01 part of caprylyl hydroxamic acid, 0.5 part of an aqueous solution of hydroxyethyl urea (with a mass concentration of 20%) and 75 parts of deionized water.

The preparation method of the repair type water-replenishing horse oil cream comprises the following steps:

(1) weighing water, allantoin and EDTA disodium according to a certain weight, adding the water, the allantoin and the EDTA disodium into an emulsifying pot, heating to 80 ℃, then weighing xanthan gum, 0.5 part of butanediol, 0.5 part of glycerol, an emulsion stabilizer of ammonium acryloyl dimethyl taurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer and sodium hyaluronate into a clean barrel, stirring, wetting and dispersing uniformly, then adding the mixture into the emulsifying pot for 2-3 times, keeping vacuum, starting stirring and homogenizing for 5 minutes until the mixture is completely dissolved uniformly to form an A-phase material;

(2) weighing phytosterol oleate, jojoba seed oil and horse fat according to the amount, adding into an oil pan, stirring and dissolving uniformly, and heating to 75-80 deg.C; adding sweet almond oil, tangerine peel oil and hydrogenated palm oil into the oil pan when the temperature in the oil pan reaches 80 ℃ to form a B-phase material;

(3) starting an emulsifying pot, vacuumizing and stirring, pumping the B-phase material in the oil pot into the emulsifying pot, and keeping vacuum, quickly stirring and dispersing uniformly;

(4) weighing p-hydroxyacetophenone according to the amount and pre-dissolving the p-hydroxyacetophenone and 0.5 part of butanediol at 65-70 ℃ to form a C-phase material uniformly; weighing the sodium polyacrylate/C13-14 isoparaffin/tridecyl alcohol polyether-6 composition according to the weight, adding the composition into an emulsifying pot, stirring and homogenizing for 1 minute, then adding the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and stirring at a medium speed in vacuum for 30 minutes; after stirring, opening the kettle, cooling to 60 ℃, and adding a C-phase material pre-dissolved uniformly in advance;

(5) weighing 0.5 part of butanediol, caprylyl hydroximic acid and ethylhexyl glycerin according to the weight, and pre-dissolving uniformly at 65-70 ℃ to form a D-phase material; adding the pre-dissolved D-phase material when the temperature in the emulsifying pot is reduced to 50 ℃;

(6) weighing betaine, bisabolol, hydroxyethyl urea aqueous solution, folium Perillae extract, and radix Glycytthizae extract at 40-45 deg.C, adding into emulsifying pot, stirring for 10 min, sampling, inspecting, and discharging.

Example 5:

a repair-type water-replenishing horse oil cream comprises 0.1 part of horse fat, 5.0 parts of jojoba seed oil, 0.01 part of sodium hyaluronate, 0.5 part of betaine, 0.1 part of phytosterol oleate, 0.1 part of sweet almond oil, 0.1 part of tangerine peel oil, 0.1 part of hydrogenated palm oil, 0.5 part of bisabolol, 0.05 part of perilla leaf extract, 0.05 part of glycyrrhiza glabra root extract, 0.05 part of xanthan gum, 0.01 part of disodium EDTA, 20.5 parts of butanediol, 0.5 part of glycerol, 5.0 parts of an emulsion stabilizer ammonium acryloyldimethyltaurate/beheneth-25 methacrylate cross-linked polymer, 1.0 part of allantoin, 0.1 part of sodium polyacrylate, C13-14 isoparaffin, a trideceth-6 composition, 0.1 part of hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer, 5.0 parts of p-hydroxyacetophenone, 0.5 parts of ethylhexylglycerol, 0.5 parts of caprylic acid, and a urea aqueous solution (the concentration is 50 mass%) (the mass percent), 0.5 part of polydimethylsiloxane, 0.5 part of glycerol acrylate/acrylic acid copolymer, glycerol, propylene glycol, PVM/MA copolymer, 0.1 part of vitamin E, 0.05 part of scutellaria baicalensis root extract, 0.05 part of peony root extract and 100 parts of deionized water.

(1) weighing water, allantoin and EDTA disodium according to a certain weight, adding the water, the allantoin and the EDTA disodium into an emulsifying pot, heating to 80 ℃, then weighing xanthan gum, 0.5 part of butanediol, 0.5 part of glycerol, an emulsion stabilizer ammonium acryloyldimethyltaurate/behenyl polyether-25 methacrylate cross-linked polymer and sodium hyaluronate into a clean barrel, stirring, wetting and dispersing uniformly, adding the mixture into the emulsifying pot for 2-3 times, keeping vacuum, starting stirring and homogenizing for 5 minutes until the mixture is completely dissolved uniformly to form an A-phase material;

(2) weighing phytosterol oleate, jojoba seed oil, polydimethylsiloxane and horse fat according to the weight, adding into an oil pan, stirring and dissolving uniformly, and heating to 75-80 ℃; adding sweet almond oil, tangerine peel oil and hydrogenated palm oil into the oil pan when the temperature in the oil pan reaches 80 ℃ to form a B-phase material;

(4) weighing p-hydroxyacetophenone according to the amount and pre-dissolving the p-hydroxyacetophenone and 10 parts of butanediol at 65-70 ℃ to form a C-phase material uniformly; weighing the sodium polyacrylate/C13-14 isoparaffin/tridecyl alcohol polyether-6 composition according to the weight, adding the composition into an emulsifying pot, stirring and homogenizing for 1 minute, then adding the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and stirring at a medium speed in vacuum for 30 minutes; after stirring, opening the kettle, cooling to 60 ℃, and adding a C-phase material pre-dissolved uniformly in advance;

(5) weighing 10 parts of butanediol, caprylyl hydroximic acid and ethylhexyl glycerol according to the weight, and pre-dissolving uniformly at 65-70 ℃ to form a D-phase material; adding the pre-dissolved D-phase material when the temperature in the emulsifying pot is reduced to 50 ℃;

(6) weighing betaine, bisabolol, hydroxyethyl urea aqueous solution, vitamin E, glyceryl acrylate/acrylic acid copolymer, glycerol, propylene glycol, PVM/MA copolymer, folium Perillae extract, Glycyrrhiza glabra root extract, Scutellariae radix root extract, and peony root extract at 40-45 deg.C, adding into emulsifying pot, stirring for 10 min, sampling, inspecting, and discharging.

Example 6:

a repair-type water-replenishing maleic cream comprises 5.0 parts of horse fat, 0.5 part of jojoba seed oil, 1.0 part of sodium hyaluronate, 5.0 parts of betaine, 10.0 parts of phytosterol oleate, 10.0 parts of sweet almond oil, 10.0 parts of tangerine peel oil, 10.0 parts of hydrogenated palm oil, 0.05 part of bisabolol, 3.0 parts of perilla leaf extract, 3.0 parts of glycyrrhiza glabra root extract, 1.0 part of xanthan gum, 0.1 part of disodium EDTA, 60 parts of butanediol, 30 parts of glycerol, 10.0 parts of an emulsion stabilizer of acryloyl dimethyl taurate/behenyl polyether-25 methacrylate cross-linked polymer, 0.05 part of allantoin, 0.1 part of sodium polyacrylate, C13-14 isoparaffin, tridecyl polyether-6 composition, 0.1 part of hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer, 5.0 parts of p-hydroxy acetophenone, 0.5 part of ethylhexyl glycerol, 0.5 part of caprylyl hydroxamic acid, and 0.5 parts of aqueous solution of urea (the mass concentration is 50%) 0.5 part of polydimethylsiloxane, 10.0 parts of glycerin acrylate/acrylic acid copolymer, glycerin, propylene glycol, PVM/MA copolymer, 10.0 parts of vitamin E, 1.0 part of scutellaria root extract, 1.0 part of peony root extract and 100 parts of deionized water.

The preparation method is the same as example 5.

Comparative example 1:

the comparative example examines the influence of the perilla leaf extract and the tangerine peel oil on the moisturizing effect of horse oil cream. Comparative example 1 experiments were carried out on the basis of example 1 with the proportions of the components being varied as indicated in table 1. The preparation method is the same as example 1.

TABLE 1 formulation of comparative example 1

Comparative example 2:

the comparative example examines the influence of perilla leaf extract, tangerine peel oil, jojoba seed oil, betaine and phytosterol oleate on the skin repair effect of horse oil cream. Comparative example 2 experiments were carried out on the basis of example 1 with the proportions of the components being varied according to table 2. The preparation method is the same as example 1.

Table 2 formulation of comparative example 2

Comparative example 3

The comparative example examines the influence of bisabolol and hydroxyethyl urea aqueous solutions on the moisturizing effect of sodium hyaluronate and the skin repair effect of horse fat. Comparative example 3 experiments were carried out on the basis of example 4 with the proportions of the components being varied according to table 3. The preparation method is the same as example 4.

Table 3 formulation of comparative example 3

Analysis of results

Test 1 horse oil cream stability test

The test method comprises the following steps:

(1) heat resistance: after different embodiments of horse oil cream are stored for 150 days at 40 ℃, the horse oil cream is visually observed to find whether the horse oil cream has obvious differences with the characters and colors before the test, and whether the horse oil cream has the phenomena of layering, oil floating and dry cracking.

(2) And (3) test results: see table 4.

TABLE 4 comparison of stability of different horse oil creams

Group of	Before the test, the phenomena of layering, floating oil and dry cracking exist	The phenomena of delamination, floating oil and dry cracking after the heat resistance test
			Example 1	Is composed of	Is composed of
Example 2	Is free of	Is free of
			Example 3	Is composed of	Is free of
Example 4	Is free of	Is composed of
			Example 5	Is free of	Is composed of
Example 6	Is free of	Is composed of

And (4) test conclusion: stability tests show that the product produced by the preparation method of the horse oil cream has good stability, the phenomena of layering, oil floating and dry cracking of the product due to long-time precipitation can be avoided, the coexistence environment of bacteria can be still damaged under the condition that no preservative is added, and the deterioration time of the product is prolonged.

Experiment 2, investigating the influence of perilla leaf extract and tangerine peel oil on the moisturizing effect of horse oil cream

180 female volunteers aged 20-50 years were selected and divided into 9 groups of 20. The horse oil creams of examples 1-6 and comparative examples 1-1, 1-2 and 1-3 according to the invention were applied to both hands 2 times a day for 12 days, respectively, to 9 groups of volunteers. Skin moisture and elasticity are closely related to moisture contained in the epidermis, excessive loss of skin moisture can cause skin dryness, reduced elasticity, and even chapping, the degree of moisture retention of hands of a person applying the skin is measured daily by a conductivity meter (the skin is a poor conductor of electricity, the resistance is reduced when the moisture content of the skin is increased, and the more the resistance is reduced, the better the moisture retention is), the measurement is carried out in a room with the temperature of 22-24 ℃ and the relative humidity of 35-45%, and the results are shown in table 5 (all measured at 8 hours after application).

TABLE 5

And (4) test conclusion: the perilla leaf extract and the tangerine peel oil in an optimized proportion are added in the formula, so that the hyaluronic acid injection has a stronger promotion effect on the generation of hyaluronidase, can depolymerize and loosen the hyaluronic acid better, promotes the accelerated diffusion of local accumulated liquid, is easier to absorb, and fully exerts the moisturizing effect of moisturizing nutritional ingredients on skin.

Experiment 3, investigating the influence of perilla leaf extract, tangerine peel oil, jojoba seed oil, betaine and phytosterol oleate on the skin repair effect of horse oil cream

Case-related data: 240 subjects with loose and rough skin, multiple wrinkles and multiple epidermal pigmentation were selected, and the age was between 30 and 55 years. Examples 1 to 6 and comparative examples 2 to 1 to 2 to 6 were 20 subjects each.

The using method comprises the following steps: after thoroughly cleaning the skin, the horse oil cream prepared in examples 1-6 and comparative examples 2-1 to 2-6 was uniformly applied to the skin, gently patted, and used once in the morning and evening, with each 28 days as a treatment course, for 1-4 treatment courses.

And (4) judging the standard:

the effect is shown: the user feels very satisfactory, horse oil cream is well absorbed and is not greasy, the skin has elasticity which is tighter and smoother, the skin is fine and smooth, the skin is permanently moist, soft and glossy, and wrinkles are obviously reduced; the texture density of the skin is obviously reduced under a microscope, and the color of the skin is obviously lightened. The subjects had no allergic or other toxic side effects.

The method has the following advantages: the user feels generally satisfied with the self, horse oil cream is well absorbed and is not greasy, and the elastic, glossy and smooth degree of the skin is increased; wrinkles are reduced; microscopically, the texture density of the skin is reduced and the color of the skin becomes lighter.

And (4) invalidation: the user feels dissatisfied, the rough and dry feeling of the skin is not obviously improved, the wrinkles are not reduced, and the elastic, glossy and smooth degree of the skin is not increased; no obvious improvement of skin texture density and no obvious improvement of epidermal pigmentation under a microscope.

The use effect is as follows:

the 240 cases were recorded and reviewed, and the specific results are shown in table 6:

TABLE 6

And (4) test conclusion: the perilla leaf extract and the tangerine peel oil in the optimized proportion are added in the formula, and the perilla leaf extract and the tangerine peel oil in the optimized proportion and the jojoba seed oil, the betaine and the phytosterol oleate in the optimized proportion act together, so that pores can be unblocked, the permeability and the water absorption of skin are improved, and simultaneously, the saturated fatty acid alpha-linolenic acid in horse fat is fully absorbed, the skin metabolism is promoted, the oil secretion is regulated, and the damaged cells of the skin are repaired. Even if the skin is subjected to high osmotic pressure of the external environment, which causes a great loss of cell osmolytes, the horse oil cream of the invention can inhibit the process to a certain extent and protect the balance of cells through the penetration of the skin cuticle.

Test 4, investigation of the effects of bisabolol and hydroxyethylurea aqueous solutions on the moisturizing effect of sodium hyaluronate and the skin repair effect of horse fat

(1) Influence on moisturizing effect of horse oil cream

60 female volunteers aged 20-50 years were selected and divided into 3 groups of 20. The horse oil creams of example 4 and comparative examples 3-1 and 3-2 according to the invention were applied to both hands 2 times a day for 12 days in 3 groups of volunteers. The moisture retention of the hands of the applicator was measured daily by a conductivity meter (skin is an electrically poor conductor, the resistance decreases as the moisture content of the skin increases, the more the resistance decreases the better the moisture retention), the measurement was carried out in a room at a temperature of 22-24 ℃ and a relative humidity of 35-45%, and the results are shown in Table 7 (all measured at 8 hours after application).

TABLE 7

Experiments show that when the bisabolol and the hydroxyethyl urea aqueous solution with the optimized proportion are added, the sodium hyaluronate has more remarkable water replenishing and moisturizing effects.

(2) Influence on skin repair effect of horse oil cream

Case-related data: 60 test subjects with loose and rough skin, much wrinkles and much epidermal pigmentation are selected, and the age is between 30 and 55 years old. Example 4, comparative example 3-1, comparative example 3-2 each 20 subjects.

The application method and the evaluation standard are the same as those of experiment 3.

The use effect is as follows:

the results of the recording and the return visit of the 60 cases are shown in Table 8:

TABLE 8

Experiments show that when the bisabolol and the hydroxyethyl urea aqueous solution with the optimized proportion are added, the skin repair effect of the horse fat is more obvious.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered as the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.

Claims

1. The repairing type water-replenishing horse oil cream is characterized by comprising, by weight, 0.1-5.0 parts of horse fat, 0.5-10.0 parts of jojoba seed oil, 2.01-67.0 parts of a skin conditioner, 0.25-11.0 parts of a thickening agent, 0.1-10.0 parts of an emulsion stabilizer, 0.02-1.2 parts of a chelating agent, 2.51-101.0 parts of a humectant and 50-100 parts of deionized water;

the thickening agent comprises 0.05-1.0 part of xanthan gum;

the chelating agent comprises 0.01-0.2 part of EDTA disodium;

2. The remedial moisturizing horse oil cream of claim 1, wherein the thickening agent further comprises one or both of a sodium polyacrylate/C13-14 isoparaffin/trideceth-6 composition or a hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer; 0.1-5.0 parts of sodium polyacrylate/C13-14 isoparaffin/tridecyl alcohol polyether-6 composition and 0.1-5.0 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

3. The remedial water-replenishing horse oil cream as claimed in claim 2, wherein the mass ratio of sodium polyacrylate, C13-14 isoparaffin and tridecyl polyether-6 in the sodium polyacrylate/C13-14 isoparaffin/tridecyl polyether-6 composition is 1: 1: 1.

4. a remedial moisturizing horse oil cream as claimed in claim 1 wherein the skin conditioning agent further comprises allantoin 0.01-1.0 parts and dimethicone 0.5-10.0 parts.

5. A remedial water-replenishing horse oil cream as claimed in claim 1, wherein the skin conditioning agent further comprises 0.5 to 10.0 parts of a glyceryl acrylate/acrylic acid copolymer, glycerin, propylene glycol, PVM/MA copolymer.

6. The remedial water-replenishing horse oil cream as claimed in claim 1, wherein the skin conditioner further comprises one or more of scutellaria baicalensis root extract, kochia scoparia extract, magnolia biondii bud/flower extract, dictamnus dasycarpus root extract, centella asiatica extract, paeonia suffruticosa root extract and saposhnikovia divaricata root extract, and the addition amount of each of the extracts is 0.05-3.0 parts.

7. A remedial water horse oil cream as claimed in claim 1 wherein the skin conditioning agent further includes 0.1 to 10.0 parts vitamin E.

8. The repairing water-replenishing horse oil cream according to claim 1, characterized in that the humectant further comprises 0.01-1.0 parts of ethylhexyl glycerin and 0.5-10.0 parts of an aqueous solution of hydroxyethyl urea, the mass concentration of the aqueous solution of hydroxyethyl urea is 20-50%; the chelating agent also comprises 0.01-1.0 caprylyl hydroximic acid.

9. The method for preparing the remedial water-replenishing horse oil cream as claimed in claims 1 to 8, which is characterized by comprising the following steps:

(1) weighing water and EDTA disodium according to a certain amount, adding the water and the EDTA disodium into an emulsifying pot, heating to 80 ℃, then weighing xanthan gum, 0.5-20 parts of butanediol, 0.5-30 parts of glycerol, an emulsion stabilizer and sodium hyaluronate into a clean barrel, stirring, wetting and dispersing uniformly, adding the materials into the emulsifying pot for 2-3 times, keeping vacuum, starting stirring and homogenizing for 5 minutes until the materials are completely and uniformly dissolved to form an A-phase material;

(3) starting an emulsifying pot, stirring in vacuum, pumping the B-phase material in the oil pot into the emulsifying pot, and keeping vacuum and stirring rapidly to disperse uniformly;

(4) weighing betaine, bisabolol, folium Perillae extract and radix Glycytthizae extract at 40-45 deg.C, adding into emulsifying pot, stirring for 10 min, sampling, testing, and discharging.

10. The method for preparing the remedial water replenishing horse oil cream according to claim 9, which is characterized by comprising the following steps:

(4) weighing p-hydroxyacetophenone according to the amount and pre-dissolving the p-hydroxyacetophenone and 0.5 to 20 parts of butanediol at the temperature of between 65 and 70 ℃ to form a C-phase material uniformly; weighing the sodium polyacrylate/C13-14 isoparaffin/tridecyl alcohol polyether-6 composition according to the weight, adding the composition into an emulsifying pot, stirring and homogenizing for 1 minute, then adding the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and stirring at a medium speed in vacuum for 30 minutes; after stirring, opening the kettle, cooling to 60 ℃, and adding a C-phase material pre-dissolved uniformly in advance;

(6) weighing one or more of betaine, bisabolol, hydroxyethyl urea aqueous solution, vitamin E, glyceryl acrylate/acrylic acid copolymer/glycerin/propylene glycol/PVM/MA copolymer, perilla leaf extract, glycyrrhiza glabra root extract and scutellaria root extract, fructus kochiae extract, magnolia biondii bud/flower extract, dictamnus dasycarpus root extract, centella asiatica extract, peony root extract and radix sileris root extract according to the weight, adding the mixture into an emulsifying pot at the temperature of below 40-45 ℃, stirring for 10 minutes uniformly, sampling, inspecting, and discharging after the mixture is qualified.