CN113087622B - 一种依他佐辛中间体的制备方法 - Google Patents
一种依他佐辛中间体的制备方法 Download PDFInfo
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- CN113087622B CN113087622B CN202110289646.6A CN202110289646A CN113087622B CN 113087622 B CN113087622 B CN 113087622B CN 202110289646 A CN202110289646 A CN 202110289646A CN 113087622 B CN113087622 B CN 113087622B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C07C67/327—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by elimination of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202110289646.6A CN113087622B (zh) | 2021-03-15 | 2021-03-15 | 一种依他佐辛中间体的制备方法 |
Applications Claiming Priority (1)
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CN202110289646.6A CN113087622B (zh) | 2021-03-15 | 2021-03-15 | 一种依他佐辛中间体的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN113087622A CN113087622A (zh) | 2021-07-09 |
CN113087622B true CN113087622B (zh) | 2023-03-31 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN202110289646.6A Active CN113087622B (zh) | 2021-03-15 | 2021-03-15 | 一种依他佐辛中间体的制备方法 |
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CN (1) | CN113087622B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114031505B (zh) * | 2021-12-06 | 2024-02-02 | 和鼎(南京)医药技术有限公司 | 一种制备喷他佐辛中间体的方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4234731A (en) * | 1979-01-05 | 1980-11-18 | Bristol-Myers Company | 9-Oxobenzomorphan process |
JPS6461447A (en) * | 1987-08-28 | 1989-03-08 | Nihon Iyakuhin Kogyo Co Ltd | (+-)-or (+)-1-(2-n-substituted aminoethyl)-1-methyl-7-methoxy-1,2,3,4-tetrahydronaphthalene and production thereof |
CN101654445B (zh) * | 2008-08-22 | 2014-07-23 | 四川大学 | 用于制备雷美替胺的化合物、其制备方法和用途 |
CN110563605B (zh) * | 2018-06-05 | 2021-10-08 | 上海医药工业研究院 | 制备氢溴酸依他佐辛的中间体及其制备方法 |
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2021
- 2021-03-15 CN CN202110289646.6A patent/CN113087622B/zh active Active
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Effective date of registration: 20221209 Address after: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Applicant after: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Applicant after: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Applicant after: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Applicant after: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Applicant after: Euphorbia Biological Medicine Co.,Ltd. Address before: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Applicant before: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20230310 Address after: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Applicant after: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Applicant after: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Applicant after: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Applicant after: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Applicant after: Euphorbia Biological Medicine Co.,Ltd. Applicant after: Guangdong Ruishi Pharmaceutical Technology Co.,Ltd. Address before: No.6 Dongbo Road, East District, Guangzhou Economic and Technological Development Zone, Guangdong 510000 Applicant before: GUANGZHOU YIPINHONG PHARMACEUTICAL Co.,Ltd. Applicant before: GUANGDONG ZERUI PHARMACEUTICAL Co.,Ltd. Applicant before: Guangzhou Lianrui Pharmaceutical Co.,Ltd. Applicant before: Guangzhou Runlin Pharmaceutical Technology Co.,Ltd. Applicant before: Euphorbia Biological Medicine Co.,Ltd. |
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